Patents Issued in February 7, 2019
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Publication number: 20190040459Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.Type: ApplicationFiled: May 31, 2018Publication date: February 7, 2019Inventors: J. William Efcavitch, Matthew T. Holden
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Publication number: 20190040460Abstract: The invention relates to a method for the production and forgery-proof authentication of medical devices by using a nucleic acid having a known partial sequence, the method comprising the following steps: (i) producing a medical device (MED) having a permanent marking (PM), wherein the medical device (MED) comprises a polymer (P) with the permanent marking (PM) and the permanent marking (PM) contains at least one nucleic acid (NUK) with a known partial sequence (TSEQ); (ii) isolating the permanent marking (PM); and (iii) authentication of the medical device (MED) by detection of the at least one known partial sequence (TSEQ).Type: ApplicationFiled: July 25, 2018Publication date: February 7, 2019Inventors: Joachim Storsberg, Marina Volkert
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Publication number: 20190040461Abstract: Provided is a method for extracting and characterizing molecular clones. The method includes: providing a substrate on which molecular clones are formed; applying energy to desired ones of the molecular clones in a non-contact mode to extract the desired molecular clones from the substrate; chemically linking DNA barcodes to the sequences of the extracted molecular clones; and determining the DNA barcode-linked sequences by parallel sequencing.Type: ApplicationFiled: November 4, 2016Publication date: February 7, 2019Inventors: Tae Hoon RYU, Hyo Ki KIM, Hyo Jun HAN, Sung Hoon KWON
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Publication number: 20190040462Abstract: The invention is directed to sequence-based profiling of populations of nucleic acids by multiplex amplification and attachment of one or more sequence tags to target nucleic acids and/or copies thereof followed by high-throughput sequencing of the amplification product. In some embodiments, the invention includes successive steps of primer extension, removal of unextended primers and addition of new primers either for amplification (for example by PCR) or for additional primer extensions. Some embodiments of the invention are directed to minimal residual disease (MRD) analysis of patients being treated for cancer. Sequence tags incorporated into sequence reads provide an efficient means for determining clonotypes and at the same time provide a convenient means for detecting carry-over contamination from other samples of the same patient or from samples of a different patient which were tested in the same laboratory.Type: ApplicationFiled: August 2, 2018Publication date: February 7, 2019Inventors: Thomas Asbury, Kieran Hervold, Chitra Kotwaliwale, Malek Faham, Martin Moorhead, Li Weng, Tobias Wittkop, Jianbiao Zheng
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Publication number: 20190040463Abstract: An apparatus with a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus has a chemical sensing surface coupled to the transducer arranged to receive a chemical input. A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.Type: ApplicationFiled: October 2, 2018Publication date: February 7, 2019Applicant: DNAE Group Holdings LimitedInventors: Pantelis GEORGIOU, Samuel REED, Yan LIU, Christofer TOUMAZOU, Chung-Pei OU
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Publication number: 20190040464Abstract: Provided herein is a method for analyzing polynucleotides such as genomic DNA. In certain embodiments, the method comprises: (a) treating chromatin isolated from a population of cells with an insertional enzyme complex to produce tagged fragments of genomic DNA; (b) sequencing a portion of the tagged fragments to produce a plurality of sequence reads; and (c) making an epigenetic map of a region of the genome of the cells by mapping information obtained from the sequence reads to the region. A kit for performing the method is also provided.Type: ApplicationFiled: October 15, 2018Publication date: February 7, 2019Inventors: Paul Giresi, Jason D. Buenrostro, Howard Y. Chang, William J. Greenleaf
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Publication number: 20190040465Abstract: An RNA detection kit comprising: (i) a single-stranded circular DNA template containing: a sequence of 10 to 30 bases complementary to a first portion of a target RNA; a primer-binding sequence of 7 to 8 bases adjacent to 5?-side thereof; and a sequence complementary to a detection reagent-binding sequence such as a guanine quadruplex-forming sequence; (ii) an oligonucleotide primer containing: a sequence of 8 to 15 bases complementary to a second portion adjacent to the 3?-side of the first portion of the target RNA; and a sequence of 7 to 8 bases adjacent to 3?-side thereof and complementary to the primer-binding sequence of the single-stranded circular DNA template; and (iii) a detection reagent such as a guanine quadruplex-binding reagent; is provided.Type: ApplicationFiled: March 23, 2016Publication date: February 7, 2019Inventor: Masayasu Kuwahara
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Publication number: 20190040466Abstract: Compositions and methods for treating a disease are described herein. Compositions having plant preparations, microRNAs, and one or more rate limiters are administered to a patient to promote DNA damage repair and modulate endothelial and mitochondrial function, thereby allowing for healing to occur.Type: ApplicationFiled: October 23, 2017Publication date: February 7, 2019Inventor: Brandie Gowey
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Publication number: 20190040467Abstract: The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.Type: ApplicationFiled: November 2, 2017Publication date: February 7, 2019Inventors: David A. Schwartz, Max Seibold
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Publication number: 20190040468Abstract: Provided is a microarray for detecting mutations in a ?-globin gene, which is capable of detecting a large number of mutations (specimens) conveniently in a short time. A probe group for detecting mutations in a ?-globin gene containing genes having the sequences set forth in SEQ ID NOs:3, 4, 7, 11, 12, 17, 18 and 25 to 66; a microarray having the probe group immobilized thereon; a method for detecting mutations in a ?-globin gene using the microarray; and a kit for ?-globin gene mutation detection using the microarray and primers, are provided.Type: ApplicationFiled: August 16, 2018Publication date: February 7, 2019Applicant: Mitsubishi Chemical CorporationInventor: Naoyuki Togawa
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Publication number: 20190040469Abstract: Through genomic analysis a 12-gene signature comprising up-regulated genes and down-regulated genes has been identified that is highly predictive of metastasis and overall survival in human patients with HCC. Another aspect of the disclosure methods of determining the metastatic status of an hepatocellular carcinoma of a patient, comprising obtaining a first differential gene expression profile from a carcinoma sample from a subject having an hepatocellular carcinoma and creating a report summarizing the normalized data obtained by the first gene expression analysis and including a determination of the metastatic status of the hepatic carcinoma.Type: ApplicationFiled: September 9, 2016Publication date: February 7, 2019Inventors: Dean Felsher, Meital Ryan, Robert Tibshirani
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Publication number: 20190040470Abstract: Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue and for assessing the malignancy of colon cancer tumors.Type: ApplicationFiled: January 26, 2018Publication date: February 7, 2019Inventors: Gera NEUFELD, Gal AKIRI, Zahava VADASZ, Stela GENGRINOVITCH
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Publication number: 20190040471Abstract: A method to detect a biomarker in saliva wherein the biomarker is an extracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva comprises detecting a transcriptome pattern in the cell-free saliva; a method to detect genetic alterations in an organ or in a gene in the organ by analyzing saliva, comprises detecting a transcriptome pattern and/or the mRNA profiling of the gene in cell-free saliva; a method to diagnose an oral or systemic pathology disease or disorder in a subject, comprises: detecting profile of a biomarker associated with the pathology disease or disorder, in particular mRNA and/or protein, in cell-free saliva and/or serum; kits comprising identifier for at least one biomarker for performing at least one of the methods; and use of salivary biomarker salivary and/or serum mRNAs as biomarkers for oral and/or systemic pathology, disease or disorder.Type: ApplicationFiled: August 8, 2018Publication date: February 7, 2019Inventors: David T. W. Wong, Maie A. R. St. John, Yang Li
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Publication number: 20190040472Abstract: The disclosure provides gene fusions, gene variants, and novel associations with disease states, as well as kits, probes, and methods of using the same.Type: ApplicationFiled: August 14, 2018Publication date: February 7, 2019Inventors: Daniel RHODES, Seth SADIS, Peter WYNGAARD, Nikolay KHAZANOV, Santhoshi BANDLA, Mark TOMILO, Sean EDDY, Emma BOWDEN, Jia LI
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Publication number: 20190040473Abstract: The present invention relates to a gene for predicting or diagnosing the prognosis of early-stage breast cancer and to a use thereof, and more specifically relates to a genetic marker for predicting or diagnosing the prognosis of breast cancer, including TRBC1 (T cell receptor beta constant 1), BTN3A2 (butyrophilin, subfamily 3, member A2) or HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) for providing information necessary for predicting or diagnosing the prognosis of a breast cancer patient. The genetic marker of the present invention allows the prediction or diagnosis of the prognosis of a breast cancer patient, and can therefore advantageously be used for the purpose of providing a direction as to the future course of breast cancer treatment, including a decision on whether anticancer therapy is necessary.Type: ApplicationFiled: October 9, 2018Publication date: February 7, 2019Inventors: Young Kee SHIN, Young-Deug KIM, En Sel OH, Jun Young CHOI, Sang Rea CHO
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Publication number: 20190040474Abstract: The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes).Type: ApplicationFiled: October 16, 2018Publication date: February 7, 2019Inventors: Christina Fan, Stephen P.A. Fodor, Glenn Fu, Geoffrey Richard Facer, Julie Wilhelmy
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Publication number: 20190040475Abstract: Provided is a microorganism of the genus Epidermidibacterium belonging to the family Sporichthyaceae, or a culture thereof, or a composition for preventing, improving, or treating skin conditions or inflammatory diseases including the same.Type: ApplicationFiled: June 27, 2017Publication date: February 7, 2019Applicant: Cosmax Co., Ltd.Inventors: Dong Geol LEE, Jin Ju NAM, Min Ji KIM, Seung Hyun KANG, Youn Joon KIM
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Publication number: 20190040476Abstract: Provided is a microorganism of the genus Komagataeibacter having enhanced cellulose productivity and yield, a method of producing cellulose by using the same, and a method of producing the microorganism.Type: ApplicationFiled: August 1, 2018Publication date: February 7, 2019Inventors: Soonchun Chung, Sunghaeng Lee, Jinhwan Park
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Publication number: 20190040477Abstract: The present invention relates to a method for producing fatty acids, in particular shot/medium-chain fatty acids (S/MCFA), by expression in a host cell of a recombinant fatty acid synthase (FAS) naturally devoid of a thioesterase (TE) domain comprising a heterologous thioesterase (TE). The invention further relates to polynucleotides comprising such recombinant FAS, polypeptides encoded thereby, and vectors comprising such polynucleotides, as well as recombinant host cells comprising the polynucleotides, polypeptides, or vectors.Type: ApplicationFiled: February 20, 2017Publication date: February 7, 2019Inventors: Zhiwei ZHU, Anastasia KRIVORUCHKO, Jens NIELSEN
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Publication number: 20190040478Abstract: Disclosed herein are methods, systems, and compositions for the uniform pretreatment of biomass within seconds with low inhibitor formation. The pretreatment process is used to convert biomass to a fuel, sugars, or other useful chemicals by subjecting the feedstock to a rapid retention time under pressure and temperature and/or chemical reactant. The system includes at least one high pressure, steam impermiable plug and a continuously-operating valve discharge apparatus to discharge pretreated feedstock while maintaining uniform pressure on the pretreatment system.Type: ApplicationFiled: February 16, 2018Publication date: February 7, 2019Inventors: Scott TUDMAN, Sharon Samjitsingh
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Publication number: 20190040479Abstract: An ionic liquid represented by the following chemical formula, [(CH3)3N(CH2)2OH]+[NH2(CH2)3CH(NH2)COO]?, which provides an ionic liquid capable of dissolving cellulose within twenty-four hours.Type: ApplicationFiled: October 9, 2018Publication date: February 7, 2019Inventors: Takahiro AOKI, Tomoko KAWASHIMA, Haruka KUSUKAME, Yuko TANIIKE
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Publication number: 20190040480Abstract: A seamless steel pipe has a carbon equivalent Ceq of 0.50% to 0.58%, and contains specified carbides containing Mo at a ratio of 50 mass % or more, V, and at least one selected from the group consisting of Ti and Nb, and having a size of 20 nm or more.Type: ApplicationFiled: October 10, 2018Publication date: February 7, 2019Inventors: Yuji ARAI, Kenji KOBAYASHI, Hiroyuki NAGAYAMA
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Publication number: 20190040481Abstract: In one aspect, methods of foil ling tooling articles from tool steel powder compositions via additive manufacturing techniques are described herein. A method of forming a tooling article comprises consolidating powder alloy into the tooling article via an additive manufacturing technique and heat treating the tooling article to provide the tooling article hardness of 35 to 65 HRC. The tooling article can be formed of an alloy composition comprising 0.2-2 weight percent carbon, 0-1 weight percent manganese, 0-1.5 weight percent silicon, 0-0.3 weight percent nickel, 0-15 weight percent cobalt, at least two of chromium, molybdenum, tungsten and vanadium in a combined amount of 5-25 weight percent and the balance iron. As described herein, the method can further comprise hot isostatic pressing the tooling article prior to the heating treatment.Type: ApplicationFiled: August 2, 2017Publication date: February 7, 2019Inventors: Jason W. GOLDSMITH, Yingwei WU
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Publication number: 20190040482Abstract: A high-strength steel sheet having a tensile strength TS of 1320 MPa or more and excellent workability. The high-strength steel sheet has a chemical composition containing, by mass %, C: 0.20% or more and 0.40% or less, Si: 0.5% or more and 2.5% or less, Mn: more than 2.4% and 5.0% or less, P: 0.1% or less, S: 0.01% or less, Al: 0.01% or more and 0.5% or less, N: 0.010% or less, and Fe and inevitable impurities. A microstructure of the steel sheet includes, in terms of area fraction with respect to the whole steel sheet microstructure, lower bainite in an amount of 40% or more and less than 85%, martensite including tempered martensite in an amount of 5% or more and less than 40%, retained austenite in an amount of 10% or more and 30% or less, and polygonal ferrite in an amount of 10% or less (including 0%).Type: ApplicationFiled: February 7, 2017Publication date: February 7, 2019Applicant: JFE STEEL CORPORATIONInventors: Yusuke KIMATA, Yoshihiko ONO, Kenji KAWAMURA
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Publication number: 20190040483Abstract: A high-strength steel sheet having a tensile strength (TS) of 1,320 MPa or more and good workability. The high-strength steel sheet has a specific component composition and a steel microstructure containing, on an area-percentage basis with respect to the entire steel microstructure, 40% or more and less than 85% of a lower bainite, 5% or more and less than 40% martensite including tempered martensite, 10% or more and 30% or less retained austenite, and 10% or less (including 0%) polygonal ferrite, the retained austenite having an average C content of 0.60% by mass or more. Additionally, a Mn segregation value at a surface of the steel sheet is 0.8% or less, the ratio R/t of a limit bending radius (R) to a thickness (t) of the steel sheet is 2.0 or less, and tensile strength×total elongation of the steel sheet is 15,000 MPa % or more.Type: ApplicationFiled: February 7, 2017Publication date: February 7, 2019Applicant: JFE STEEL CORPORATIONInventors: Yusuke KIMATA, Yoshihiko ONO, Kenji KAWAMURA
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Publication number: 20190040484Abstract: A method to quantitatively determine the amount of deformation induced martensite as a function of temperature and strain in austenitic stainless steels is used to customize the strength and elongation characteristics of certain portions of a formed structural component. Predicting the martensitic volume fraction in a specific part location permits design of particular components with customized strength characteristics that can be consistently repeatably manufactured.Type: ApplicationFiled: August 1, 2018Publication date: February 7, 2019Inventor: Kavesary S Raghavan
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Publication number: 20190040485Abstract: A method for producing a tube of a stainless steel alloy tube which comprises the steps of hot working a stainless steel casting into a pretubular shaped workpiece or into a cylindrical bar, trepanning the cylindrical bar or machining an inner diameter of the pretubular shaped workpiece to obtain a tubular workpiece, and cold working the workpiece. The hot working comprises one of: rolling, forging, and a combination thereof. The cold working comprises flow forming or pilgering. The stainless steel tube produced with the method comprises an outer diameter greater than or equal to 152 mm, an average wall thickness greater than or equal to 2.8 mm and less than or equal to 70 mm, and a length greater than 5 m.Type: ApplicationFiled: February 2, 2017Publication date: February 7, 2019Applicants: TUBACEX INNOVACIÓN A.I.E., IBF S.P.A.Inventors: Alejandra LÓPEZ, Urbano FAINA
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Publication number: 20190040486Abstract: A method for cost effectively case hardening a component formed from a martensitic stainless steel material with a desired metallurgical condition for high temperature, high rolling contact fatigue, corrosion and spall initiation and propagation resistance bearing performance. The method describes a method to significantly reduce the carburization or carbo-nitriding process times for appreciable reduction in manufacturing cost. The Method includes the steps of: forming the component from a martensitic stainless steel material having an ASTM grain size of 9 or finer; and subjecting the component to one of a carburization and a carbo-nitriding treatment with significantly lower case hardening times for manufacturing cost-effectiveness.Type: ApplicationFiled: October 9, 2018Publication date: February 7, 2019Applicant: United Technologies CorporationInventors: Herbert A. Chin, David A. Haluck, William P. Ogden, Michael A. Moulin
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Publication number: 20190040487Abstract: A multilayer steel includes a core formed of transformation-induced plasticity (TRIP) steel. A decarburized layer is exterior to the core on at least one side thereof. The decarburized layer has reduced carbon content relative to the core. A zinc-based layer is exterior to the decarburized layer. The decarburized layer may have a composition of at least 80 percent ferrite, such that LME is reduced or mitigated. In some configurations, the decarburized layer is between 10-50 microns thick. A method of creating a coated advanced high-strength steel component is also provided. An apparatus for forming a coated advanced high-strength steel is also provided. The core of the multilayer steel may have a carbon weight-percent of less than or equal to 0.4. The decarburized layer of the multilayer steel may have a carbon weight-percent of less than or equal to 50 percent of the carbon weight-percent of the core.Type: ApplicationFiled: August 4, 2017Publication date: February 7, 2019Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLCInventors: Charles Enloe, Curt D. Horvath, David Yang, Qi Lu, Wu Tao
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Publication number: 20190040488Abstract: A steel plate for high-strength and high-toughness steel pipes has a chemical composition containing, by mass %, C: 0.03% or more and 0.08% or less, Si: more than 0.05% and 0.50% or less, Mn: 1.5% or more and 2.5% or less, P: 0.001% or more and 0.010% or less, S: 0.0030% or less, Al: 0.01% or more and 0.08% or less, Nb: 0.010% or more and 0.080% or less, Ti: 0.005% or more and 0.025% or less, and N: 0.001% or more and 0.006% or less, and further containing, by mass %, at least one selected from Cu: 0.01% or more and 1.00% or less, Ni: 0.01% or more and 1.00% or less, Cr: 0.01% or more and 1.00% or less, Mo: 0.01% or more and 1.00% or less, V: 0.01% or more and 0.10% or less, and B: 0.0005% or more and 0.0030% or less, with the balance being Fe and inevitable impurities. The steel plate has a microstructure in which an area fraction of ferrite at a ½ position of a thickness of the steel plate is 20% or more and 80% or less and deformed ferrite constitutes 50% or more and 100% or less of the ferrite.Type: ApplicationFiled: January 23, 2017Publication date: February 7, 2019Applicant: JFE Steel CorporationInventors: Hideyuki Kimura, Ryo Nagao, Nobuyuki Ishikawa, Kazukuni Hase
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Publication number: 20190040489Abstract: A high-strength steel sheet for warm working having excellent warm workability, and a method for manufacturing the steel sheet. The steel sheet has a chemical composition including, by mass %, C: 0.05% to 0.20%, Si: 3.0% or less, Mn: 3.5% to 8.0%, P: 0.100% or less, S: 0.02% or less, Al: 0.01% to 3.0%, N: 0.010% or less, one or more selected from Nb: 0.005% to 0.20%, Ti: 0.005% to 0.20%, Mo: 0.005% to 1.0%, and V: 0.005% to 1.0%. The steel sheet has a microstructure including, in terms of area ratio, 10% to 60% of retained austenite, 10% to 80% of ferrite, 10% to 50% of martensite, and 0% to 5% of bainite, in which a C content in the retained austenite is less than 0.40 mass % and the average crystal grain diameter of the retained austenite, the martensite, and the ferrite is 2.0 ?m or less.Type: ApplicationFiled: January 26, 2017Publication date: February 7, 2019Applicant: JFE STEEL CORPORATIONInventors: Hiroshi HASEGAWA, Yoshimasa FUNAKAWA
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Publication number: 20190040490Abstract: Provided is a high-strength cold-rolled steel sheet has a chemical composition containing, by mass %, C: 0.10% or more and 0.6% or less, Si: 1.0% or more and 3.0% or less, Mn: more than 2.5% and 10.0% or less, P: 0.05% or less, S: 0.02% or less, Al: 0.01% or more and 1.5% or less, N: 0.005% or less, Cu: 0.05% or more and 0.50% or less, and the balance being Fe and inevitable impurities, and a tensile strength of 1180 MPa or more, in which a steel sheet surface coverage of oxides mainly containing Si is 1% or less, a steel sheet surface coverage of iron-based oxides is 40% or less, CuS/CuB is 4.0 or less, and a tensile strength is 1180 MPa or more, where CuS denotes a Cu concentration in a surface layer of a steel sheet and CUB denotes a Cu concentration in base steel.Type: ApplicationFiled: February 15, 2017Publication date: February 7, 2019Applicant: JFE Steel CorporationInventors: Shimpei Yoshioka, Yoshihiko Ono, Yusuke Kimata, Hiroyuki Masuoka
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Publication number: 20190040491Abstract: A thermally treated metal sheet or article as well as processes and systems for making the thermally treated sheet or article is provided. The process comprises heating and/or cooling the metal sheet by non contact thermal conduction for sufficiently long to provide a desired microstructure and mechanical properties. The process results in thermally treated metal sheets.Type: ApplicationFiled: January 27, 2017Publication date: February 7, 2019Inventors: Dana Craig Bookbinder, Theresa Chang, Jeffrey John Domey, Peter Joseph Lezzi, Richard Orr Maschmeyer, John Christopher Thomas, Kevin Lee Wasson
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Publication number: 20190040492Abstract: The present invention provides a method for easy and efficient recovery of high purity scandium from nickel oxide ore, the method comprising: an adsorption step for passing a scandium-containing solution through an ion exchange resin to adsorb scandium on the ion exchange resin; an elution step for eluting scandium from the ion exchange resin to obtain a post-elution solution; an impurity extraction step in which after the elution step, the scandium-containing solution is subjected to a first solvent extraction using an amine-based impurity extractant and is separated into a first aqueous phase containing scandium and into a first organic phase containing impurities; and a scandium extraction step in which the first aqueous phase is subjected to a second solvent extraction using an amide derivative-containing scandium extractant to obtain a second organic phase containing scandium.Type: ApplicationFiled: January 31, 2017Publication date: February 7, 2019Inventors: Itsumi Matsuoka, Hiroshi Kobayashi, Yusuke Senba
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Publication number: 20190040493Abstract: The present invention discloses a production system for a hafnium crystal bar and the method thereof. The technical program includes a power supply unit with large DC current, an iodizer, a molybdenum insulator provided inside the iodizer, a thermostatic device, a cooling unit, a vacuum unit, an iodine box for iodizing the iodizer, an electrode unit electrically connected to the power supply unit, wherein the electrode unit is disposed above the iodizer, a crystallization unit provided inside the iodizer, wherein the crystallization unit is connected to the electrode unit, and a rough hafnium provided between the iodizer and the molybdenum insulator. The thermostatic device is a structure with an insulation layer provided outside an inner tank, and an electric heating wire is provided between the inner tank and the insulation layer. The inner tank of the thermostatic device is filled with a saline solution.Type: ApplicationFiled: September 30, 2017Publication date: February 7, 2019Applicant: Nanjing Youtian Metal Technology Co.,Ltd.Inventor: Huaihao CHEN
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Publication number: 20190040494Abstract: Recovery of scandium from mined red mud includes adding an acid to a quantity of red mud for converting oxides in the red mud, and roasting the quantity of red mud for decomposing compounds having low thermal stability, typically iron and titanium. Water is added to the roasted red mud for leaching the converted oxides into a leach liquor mixture including scandium and other dissolved rare earths, and the leach liquor mixture is agitated by sonication or ball milling to increase an exposed surface area of red mud particles in the leach liquor. PH of the leach liquor is adjusted to precipitate the rare earths while leaving the scandium in solution in the leach liquor, followed by precipitating the separated scandium oxalate remaining in the leach liquor by reducing the pH and adding oxalic acid. Precipitated scandium oxalate may then be filtered from the leach liquor.Type: ApplicationFiled: July 9, 2018Publication date: February 7, 2019Inventors: Marion H. Emmert, Remya P. Narayanan
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Publication number: 20190040495Abstract: A bi-continuous composite of a refractory alloy and copper, and a method for manufacturing the same, are provided. The method for manufacturing a bi-continuous composite of a refractory alloy and copper includes: providing an alloy melt swapping (AMS) precursor; providing a copper melt with a temperature in a range of 1085° C. to 3410° C.; immersing the AMS precursor into the copper melt; and removing the AMS precursor from the copper melt. The AMS precursor includes elements having positive and negative mixing enthalpy with copper, respectively. The AMS precursor into which the copper melt is diffused becomes a bi-continuous composite with a first phase formed from the copper and a second phase formed from the AMS precursor.Type: ApplicationFiled: February 12, 2018Publication date: February 7, 2019Inventors: Kooknoh Yoon, Il-Hwan Kim, Hyun Seok Oh, Sang Jun Kim, Eun Soo Park
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Publication number: 20190040496Abstract: The present invention provides an aluminum hybrid metal matrix composite including cerium and graphite. The aluminum-cerium intermetallic is stable at temperatures up to a melting point of aluminum and graphite provides in situ lubrication. This stability is advantageous in applications such as cylinder liners and other applications where strength and stiffness at elevated temperatures are required.Type: ApplicationFiled: August 7, 2018Publication date: February 7, 2019Inventors: David J. Weiss, Pradeep K. Rohatgi, Christopher T. Jordan, Simon S. Beno, James. H. Hunter, III, Benjamin F. Schultz
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Publication number: 20190040497Abstract: In an embodiment, an alloy is exposed to a hydrophilic solvent at least until at least one Group I or Group II element is substantially removed so as to produce a nanomaterial that substantially includes a metal, semimetal or non-metal material and that exhibits a desired set of microstructure characteristics. The hydrophilic solvent is configured to be reactive with respect to the at least one Group I or Group II element and substantially unreactive with respect to the metal, semimetal or non-metal material. In another embodiment, an active material is infiltrated into pores of a nanoporous metal or metal oxide, after which the infiltrated nanoporous metal or metal oxide material is annealed to produce an active material-based nanocomposite material. A protective coating layer is deposited on at least part of a surface of the active material-based nanocomposite material.Type: ApplicationFiled: August 1, 2018Publication date: February 7, 2019Applicant: Georgia Tech Research CorporationInventors: Gleb YUSHIN, Kostiantyn TURCHENIUK, James BENSON
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Publication number: 20190040498Abstract: A copper-based alloy casting includes 69 to 88% of Cu, 2 to 5% of Si, 0.0005 to 0.04% of Zr, 0.01 to 0.25% of P by mass, and a remainder including Zn and inevitable impurities, and satisfies 60?Cu?3.5×Si?3×P?71. Further, mean grain size after melt-solidification is 100 ?m or less, and ?, ? and ?-phases occupy more than 80% of phase structure. Furthermore, the copper-based alloy casting according to the invention can further include at least one element selected from a group consisting of 0.001 to 0.2% of Mg, 0.003 to 0.1% of B, 0.0002 to 0.01% of C, 0.001 to 0.2% of Ti and 0.01 to 0.3% of rare earth element.Type: ApplicationFiled: July 12, 2018Publication date: February 7, 2019Inventor: Keiichiro Oishi
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Publication number: 20190040499Abstract: The present invention is directed to an unleaded free cutting brass alloy with excellent machinability, leak-tightness, reca stability, and mechanical properties, wherein the brass alloy comprises 65 to 75 weight % of copper, 22.5 to 32.5 weight % of zinc, 0.5 to 2.0 weight % of silicon, and other unavoidable impurities; wherein the total content of copper and zinc in the brass alloy is 97.5 weight % or more.Type: ApplicationFiled: January 12, 2017Publication date: February 7, 2019Applicant: Fortune Manufacturing Co., Ltd.Inventors: Chin-Lung CHEN, Jhewn-Kuang CHEN, Ci-Jie HUNG
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Publication number: 20190040500Abstract: The present invention discloses a new alloy design of precipitation strengthened high entropy superalloy (HESA), which is composed of at least one principal element, a plurality of base element, and at least one precipitation strengthening element for controlling the elemental segregation between the high-entropy matrix and ordered precipitate. Through the addition of the precipitation strengthening element, while substituting the same amount of the principle element, not only the ordering energy and the volume fraction of strengthening precipitates, but also the mechanical strength of the alloy can be apparently elevated. Therefore, this newly-developed precipitation strengthened HESA can further improve the thermal capability and mechanical properties from the previously proposed high-entropy alloys.Type: ApplicationFiled: September 25, 2017Publication date: February 7, 2019Inventors: AN-CHOU YEH, TE-KANG TSAO
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Publication number: 20190040501Abstract: A Ni—Co alloy includes 30 to 65 wt % Ni, >0 to max. 10 wt % Fe, >12 to <35 wt % Co, 13 to 23 wt % Cr, 1 to 6 wt % Mo, 4 to 6 wt % Nb+Ta, >0 to <3 wt % Al, >0 to <2 wt % Ti, >0 to max. 0.1 wt % C, >0 to max. 0.03 wt % P, >0 to max. 0.01 wt % Mg, >0 to max. 0.02 wt % B, >0 to max. 0.1 wt % Zr, which fulfils the following requirements and criteria: a) 900° C.<?? solvus temperature<1030° C. with 3 at %<Al+Ti (at %)<5.6 at % and 11.5 at %<Co<35 at %; b) stable microstructure after 500 h of ageing annealing at 800° C. with a ratio Al/Ti>5 (on the basis of the contents in at %).Type: ApplicationFiled: October 1, 2018Publication date: February 7, 2019Applicant: VDM Metals International GmbHInventors: Budo GEHRMANN, Jutta KLOEWER, Tatiana FEDOROVA, Joachim ROESLER
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Publication number: 20190040502Abstract: Disclosed is an aluminum alloy composition for die casting, including 0.85 to 1.2 wt % of copper, 0.15 to 0.2 wt % of silicon, 0.08 to 0.1 wt % of magnesium, 0.08 to 0.12 wt % of zinc, 1.5 to 2.5 wt % of iron, and inevitable impurities, with the remainder of aluminum. This aluminum alloy composition for die casting can exhibit superior mechanical properties and thermal conductivity, and can be prevented from sticking to a mold, thereby increasing die-casting efficiency.Type: ApplicationFiled: May 25, 2018Publication date: February 7, 2019Applicant: SEOJINSYSTEM CO., LTD.Inventors: Dong Kyu JUN, Tae Hong KIM
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Publication number: 20190040503Abstract: Some variations provide a method of making an additively manufactured metal component, comprising: providing a feedstock that includes a high-vapor-pressure metal; exposing a first amount of the feedstock to an energy source for melting; and solidifying the melt layer, thereby generating a solid layer of an additively manufactured metal component. The metal-containing feedstock is enriched with a higher concentration of the high-vapor-pressure metal compared to its concentration in the additively manufactured metal component. The high-vapor-pressure metal may be selected from Mg, Zn, Li, Al, Cd, Hg, K, Na, Rb, Cs, Mn, Be, Ca, Sr, or Ba, for example. Additively manufactured metal components are provided.Type: ApplicationFiled: June 2, 2018Publication date: February 7, 2019Inventors: John H. MARTIN, Brennan D. YAHATA
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Publication number: 20190040504Abstract: A particulate feedstock for an additive manufacturing process includes particles formed from an aluminum base alloy. The alloy includes both aluminum and copper, and the amount of aluminum in the alloy is greater than the amount of copper in the alloy as a percentage of total weight. The alloy also includes at least one other material including at least one of magnesium manganese, titanium, nickel, and boron. The amount of copper in the alloy is greater than the amounts of each of the magnesium, manganese, titanium, nickel, and/or boron included in the alloy to render the particulate amenable to high energy density joining techniques.Type: ApplicationFiled: October 8, 2018Publication date: February 7, 2019Inventors: William L. Wentland, Eric W. Karlen
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Publication number: 20190040505Abstract: High strength forged aluminum alloys and methods for producing the same are disclosed. The forged aluminum alloy products may have grains having a high aspect ratio in at least two planes, generally the L-ST and the LT-ST planes. The forged aluminum alloy products may also have a high amount of texture. The forged products may realize increased strength relative to conventionally prepared forged products of comparable product form, composition and temper.Type: ApplicationFiled: October 11, 2018Publication date: February 7, 2019Inventors: Dustin M. Bush, Edward L. Colvin, Roberto J. Rioja, Ralph R. Sawtell
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Publication number: 20190040506Abstract: Provided are a stainless steel component having excellent corrosion resistance and abrasion resistance and a method for manufacturing the same, a stainless steel member suitable for fabricating the component, and a method for manufacturing the stainless steel member. The present invention is a stainless steel member having a thickness of 0.3 mm or less and having a component composition comprising, in terms of mass %, 0.10-0.40% C, 1.00% or less of Si, 0.10-1.50% Mn, 10.0-18.0% Cr, and 2.00% or less of N, the remainder being Fe and impurities, wherein the amount of N in a depth range of at least 0.05 mm from the surface of the stainless steel member is 0.80-2.00 mass %. The present invention is also a method for manufacturing the stainless steel member, a stainless steel component which uses the stainless steel member, and a method for manufacturing the stainless steel component.Type: ApplicationFiled: March 6, 2017Publication date: February 7, 2019Applicant: Hitachi Metals, Ltd.Inventor: JUNICHI NISHIDA
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Publication number: 20190040507Abstract: A method for producing a motor vehicle component from a 6000 series aluminum alloy including providing a blank made of a 6000 series aluminum alloy, rapid heating of the blank to a temperature between 450 deg. C. and 600 deg. C. at a heating rate of more than 15 K/s in a period of less than 20 seconds, ending the heating process and optionally homogenizing, if a grain size between 20 and 50 ?m has been produced, quenching the blank thus tempered, applying a lubricant, preferably at 20 deg. C. to 100 deg. C., forming the cooled blank in a forming tool, wherein the time between completion of the heating process and the start of the forming is less than 30 seconds, and aging.Type: ApplicationFiled: August 3, 2018Publication date: February 7, 2019Inventors: Jochem GREWE, Feng JIAO, Friedrich BOHNER, Jörn TÖLLE, Nikolay Soritov
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Publication number: 20190040508Abstract: The invention relates to a rolled product having a thickness of at least 50 mm made of aluminium alloy comprising, in % by weight, 2.2% to 3.9% of Cu, 0.7% to 1.8% of Li, 0.1% to 0.8% of Mg, 0.1% to 0.6% of Mn; 0.01% to 0.15% of Ti, at least one element chosen from Zn and Ag, the amount of said element, if it is chosen, being 0.2% to 0.8% for Zn and 0.1% to 0.5% for Ag, optionally at least one element chosen from Zr, Cr, Sc, Hf, and V, the amount of said element, if it is chosen, being 0.04% to 0.18% for Zr, 0.05% to 0.3% for Cr and for Sc, 0.05% to 0.5% for Hf and for V, less than 0.1% of Fe, less than 0.1% of Si, the remainder being aluminium and inevitable impurities, having a content of less than 0.05% each and 0.15% in total; characterized in that its granular structure is predominantly recrystallised between ¼ and ½ thickness. The invention also relates to the process for manufacturing such a product.Type: ApplicationFiled: February 3, 2017Publication date: February 7, 2019Applicant: CONSTELLIUM ISSOIREInventors: Jean-Christophe EHRSTROM, Carla DA FONSECA BARBATTI