Patents Issued in February 19, 2019
  • Patent number: 10208262
    Abstract: An improved process for the catalytic gasification of a carbonaceous feedstock in a dual fluidized bed reactor for producing synthesis gas is disclosed. The disclosure uses ?-alumina as a catalyst support i and heat carrier in the gasification zone (102). The gasification zone (102) is operated at 700-750° C. to prevent substantial conversion of ?-alumina to ?-alumina, which would manifest in the enablement of high catalyst loading and high recyclability. The catalyst is an alkali metal, preferably K2CO3, so that conversion proportional to total K2CO3 to solid carbon ratio is achieved with as high K2CO3 loading as 50 wt % on the solid support. The combustion zone (140) is operated at 800°-840° C., to prevent any conversion of the ?-alumina to ?-alumina, so that catalyst recyclability of up to 98% is achieved between two successive cycles.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: February 19, 2019
    Assignee: Reliance Industries Limited
    Inventors: Sateesh Daggupati, Sukumar Mandal, Asit Kumar Das, Ajit Vishwanath Sapre
  • Patent number: 10208263
    Abstract: A hybrid plasma reactor system that uses multiple sets of long electrodes that are placed longitudinally opposite each other within modular plasma units. The plasma units can be stacked to form an elongated plasma zone. The electrode assemblies extend into access ports. Each of the electrode assemblies has an electrode tip mounted in a tubular support jacket. A gas conduit for a supplied working gas surrounds at least a portion of the tubular support jacket. An arc is created at the electrode tip. A working gas flows through the gas conduit and is directed into the arc, therein creating plasma within the internal plasma zone.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: February 19, 2019
    Assignee: Cogent Energy Systems, Inc.
    Inventor: Peter Chuen Sun Kong
  • Patent number: 10208264
    Abstract: A formulation and methods for making high energy organic fuels that incorporate suspended metal particles with metal particle sized ranging from 33 nm to 5 micron. The hybrid organic fuels contain superior density and/or energy content to conventional liquid organic fuels. These hybrid organic fuels used in combination with metal particle afford fuels with 5 to 80% more net heat of combustion (based on volume). These fuels should extend the distant range for jets, liquid rocket engines, SCRAM jet engines, and improve energy content in fuel-air explosive applications such as fuel-air explosives and in the Multi-Effects Weapons System (MEWS) where the fuel is used both for propulsion and explosive effects.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: February 19, 2019
    Assignee: The United States of America as Represented by the Secretary of the Navy
    Inventors: Michael E. Wright, Kelvin T. Higa
  • Patent number: 10208265
    Abstract: An oleaginous corrosion-resistant lubricating composition comprising at least one poly-alpha olefin synthetic oil and effective amounts of metal salts of sulfonic acids, metal salts of carboxylic acids, metal salts of mixtures of said sulfonic and carboxylic acids, alkylated aromatic stabilizers as solubility modifiers, pour-point depressants, at least one antioxidant, triazole deactivator compounds and fluoroacrylate copolymers.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: February 19, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventor: El Sayad Arafat
  • Patent number: 10208266
    Abstract: A working fluid whose base material is a glycol, characterized in that such working fluid contains a modified silicone oil.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: February 19, 2019
    Assignee: CCI CORPORATION
    Inventors: Nobuyuki Kaga, Junichiro Kimura
  • Patent number: 10208267
    Abstract: The present technology includes an extreme pressure additive package formulated with a biodegradable sulfur component, which additive package can achieve suitable extreme pressure performance when formulated into a fully formulated industrial gear oil lubricant.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: February 19, 2019
    Assignee: The Lubrizol Corporation
    Inventors: Shubhamita Basu, James N. Vinci, Michael S. Wragg
  • Patent number: 10208268
    Abstract: The disclosure relates to an improved grease composition for use in constant velocity joints, especially ball joints and/or tripod joints used in the drivelines of motor vehicles, with the grease composition comprising at least one base oil, at least one simple or complex soap thickener, at least one zinc sulphonate, at least one molybdenum dithiocarbamate in the solid state, and at least one molybdenum dithiophosphate.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: February 19, 2019
    Assignee: GKN Driveline International GmbH
    Inventors: Jisheng E, Stefanie Rosenkranz, Jörg Berlingen, Frank Reher
  • Patent number: 10208269
    Abstract: According to the present disclosure, there is provided a high-temperature lubricant composition. The composition has an amount of an ester. The ester exhibits a kinematic viscosity at 100° C. of 1 to 4 centistokes and a kinematic viscosity ratio at 150° C./100° C. of 0.6 or higher. The composition is at a temperature of 100° C. to 150° C. There is also another lubricating composition having the ester and a polymeric viscosity modifier. There are also methods for using the lubricating compositions in the crankcase of an engine.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: February 19, 2019
    Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Jason Z. Gao, Samuel C. Bainbridge, Dennis A. Gaal, Tomasz M. Young
  • Patent number: 10208270
    Abstract: The present invention relates to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: February 19, 2019
    Assignee: BASF Plant Science Company GmbH
    Inventors: Toralf Senger, Laurent Marty, Sten Stymne, Jenny Lindberg Yilmaz, Johnathan A. Napier, Olga Sayanova, Richard Haslam, Ruiz Lopez Noemi
  • Patent number: 10208271
    Abstract: Process for the catalytic hydrogenation of vegetable oils wherein the oil is placed in contact with molecular hydrogen in the presence of a metal catalyst, and the process is performed in the absence of water or in the presence of a quantity of water equal to or less than 5:1 with respect to the weight of the metal catalyst and at a temperature equal to or less than 50° C.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: February 19, 2019
    Assignee: NOVAMONT S.P.A.
    Inventors: Giampietro Borsotti, Luigi Capuzzi, Francesca DiGioia
  • Patent number: 10208272
    Abstract: Rinse aid compositions, methods of use, and methods of making said composition are disclosed. The rinse aid compositions can be solid or liquid. The rinse aid compositions comprise a defoamer, a sheeting agent, and a terpolyer of of maleic, vinyl acetate, and ethyl acrylate. Preferred sheeting agents include one or more alcohol ethyoxylates. Preferred defoamer components include a polymer compound including one or more ethylene oxide groups. The solid rinse aid compositions are preferably substantially free of sulfate and sulfate-containing compounds.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: February 19, 2019
    Assignee: Ecolab USA Inc.
    Inventors: Erik C. Olson, Carter M. Silvernail
  • Patent number: 10208273
    Abstract: The invention relates to drain cleaning compositions including relatively high concentrations of a hypochlorite oxidizing agent and a hydroxide (e.g., 4 to 12% and 2.5 to 10%, respectively. The composition further includes a surfactant (e.g., a surfactant blend, water, and exhibits a very high pH (e.g., at least 13). The composition is monophasic, even at high oxidizing and hydroxide concentrations. The surfactant may include a blend of an uncharged surfactant (e.g., an amphoteric surfactant or nonionic surfactant) and a charged surfactant (e.g., anionic, cationic, or a surfactant that becomes so under the high pH conditions of the composition). The ratio of charged to uncharged surfactant may be at least 1:10, e.g., from 1:10 to about 1:50.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: February 19, 2019
    Assignee: The Clorox Company
    Inventors: Rashda Khan, Daniela Fritter, Lorinda Alcantara, Wenyu Zhang, Miranda Helmer
  • Patent number: 10208274
    Abstract: An acidic cleaning composition and related methods of use for rapidly cleaning and sanitizing hard contact surfaces in the food and beverage industry. The acidic cleaning composition includes a concentrated acidic solution, a strong oxidizer, a surfactant, a suitable solvent and/or sufficient quantities of water. The acidic cleaning composition rapidly removes soils from food and beverage contact surfaces such as, for example, brewing vats and kegs, without requiring CO2 be removed from the brewery vessel. The acidic cleaning composition can be in a concentrated form for dilution with additional dilution water at ambient or faucet temperature as opposed to requiring the use of “hot” water. The acidic cleaning composition is free-rinsing leaving essentially no residue on the contact surface. The surfactant provides low-foam properties so as to avoid cavitation and damage within a pump assembly.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: February 19, 2019
    Assignee: ZEE COMPANY
    Inventors: James Diamantis, Keith Seyfried, Jonathon R. Bullard, James A. Faller, Robert C. Bullard
  • Patent number: 10208275
    Abstract: The present invention relates to aqueous compositions of associative polyelectrolyte complexes (PECs), optionally containing surfactants, biocidal agents and/or oxidants, which can provide a cleaning benefit and surface protection to treated articles including reduced soiling tendency, reduced cleaning effort and improved soil repellency, as well as providing bacteriostatic properties to treated surfaces that thereby gain resistance to water, environmental exposure and microbial challenge.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: February 19, 2019
    Assignee: The Clorox Company
    Inventors: David R. Scheuing, William L. Smith, Michael Kinsinger, Jared Heymann
  • Patent number: 10208276
    Abstract: A tank receives, mixes, and dispenses input materials including algae feed stock, a micro-nutrients, cleaning solution, a sterile gas, a heating/cooling fluid, carbon dioxide, and raw water with a water treatment system. A plurality of output stations include a vent to atmosphere, a heating/cooling media return, a cleaning disposal, and an algae concentrate/product. The vent to atmosphere is coupled to the tank. The heating/cooling media return is coupled to the heating/cooling media supply through the tank. The cleaning solution disposal station is coupled to the tank with a pump followed by a nano bubbler and an algae growing system. An algae concentrate/product station is coupled to the tank. An algae dewatering system is intermediate the tank and the algae concentrate/product. A water return line couples the algae dewatering system and the water treatment system.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: February 19, 2019
    Assignee: SIFTEX EQUIPMENT COMPANY, INC.
    Inventor: Martin L. Johnson
  • Patent number: 10208277
    Abstract: According to the present invention, a problem of closed systems, namely minimizing the number of electromagnetic valves required to control a plurality of flow paths, can be addressed, and thus a low-cost cell culture device can be achieved. In this flow-path control method for X number of flow paths satisfying X?2N, the X number of flow paths are selected by using N number of valves to simultaneously and selectively control the opening and closing of the plurality of flow paths.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: February 19, 2019
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Akihiro Shimase, Kazumichi Imai, Eiichiro Takada, Sadamitsu Aso
  • Patent number: 10208278
    Abstract: A method for culturing suspended photosynthetic organisms is provided, comprising culturing the photosynthetic organism in a flowing thin film photobioreactor, wherein the flowing thin film photobioreactor comprises a light source and a trickle-film insert comprising screen material. In a preferred embodiment, the organism is Rhodobacter grown anaerobically; In an additional preferred embodiment, the organism is Botryococcus braunii.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: February 19, 2019
    Inventor: Wayne Roger Curtis
  • Patent number: 10208279
    Abstract: The present invention relates to the field of testing and evaluation of biological samples and provides an apparatus for cultured samples including at least one independently accessible module adapted for incubating at least one of a number of samples wherein the at least one module is operatively associated with a light source and a movable optical inspection means adapted for motion about a viewing axis through the module to enable a sweeping of viewing area. The invention also provides a method of assessing cultured samples for viability, including the steps of: disposing biological samples in a substantially elliptical arrangement within a culturing chamber of an independently accessible module and imaging individual samples of the substantially elliptical arrangement with optical inspection means driven within an X-Y plane that is normal to a viewing axis through the module to obtain time lapse measurement of development of individual samples.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: February 19, 2019
    Assignee: Genea IP Holdings Pty Limited
    Inventors: Eduardo Vom, Simon Davies, Adrian Higgins, Jasmine Pouladi, Ben Stewart-Steele, Simon Spence
  • Patent number: 10208280
    Abstract: A system and method for preservation, storage and transport of biological materials by the use of at least one deformable container configured with at least one inlet at one end, an outer surface greater than 80% of the total surface of the cavities of the support and a width and length sufficient for it to be placed in contact with all the heat transfer plates of the support. The support has at least two cavities delimited by the heat transfer plates, with temperature control device, side walls and at least one main front door. The system allows improvement of the heat transfer necessary for freezing and thawing large volumes of solutions containing biological materials. It also allows to considerably accelerate the heat transfer, as well as the reproducibility and scalability of the freezing and thawing process while keeping the system very compact.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: February 19, 2019
    Assignee: INSTITUTO SUPERIOR TECNICO
    Inventors: Miguel Angelo Joaquim Rodrigues, Vitor Manuel Geraldes Fernandes
  • Patent number: 10208281
    Abstract: The invention relates to a method for cultivating cells in adhesion culture, comprising at least the following steps: a) dissolving or suspending a cross-linkable, biocompatible material having adhesion points for cells in a cell culture medium; b) suspending cells in the cell culture medium, which contains the cross-linkable, biocompatible material, or in a medium that contains at least one component that is required for the cross-linking of the cross-linkable, biocompatible material; c) introducing the cell suspension into a medium in drops under conditions that initiate or permit the cross-linking of the biocompatible material, wherein either the cell suspension or the medium into which the cell suspension is introduced in drops contains the cross-linkable biocompatible material; d) forming stable, preferably porous capsules from cross-linked biocompatible material, which capsules contain incorporated adherent cells; e) proliferating the adherent cells in the capsules for a specified time period; f) breaki
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: February 19, 2019
    Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Daniel Hans Rapoport, Miriam Voigt, Charlotte Walter
  • Patent number: 10208282
    Abstract: In one aspect, the present disclosure provides a method for self-assembly of magnetic building blocks, including distributing a plurality of building blocks in a liquid medium, each of the plurality of building blocks having a plurality of stable radicals, establishing a magnetic field interacting with at least a portion of the plurality of building blocks, guiding with the magnetic field the portion of the plurality of building blocks from a first location in the liquid medium to a second location in the liquid medium, assembling into a first construct the portion of the plurality of building blocks proximate the second location, and treating the first construct with at least one antioxidant to neutralize at least in part the plurality of stable radicals.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: February 19, 2019
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Utkan Demirci, Savas Tasoglu
  • Patent number: 10208283
    Abstract: The present invention comprises methods and systems for manipulation of media and particles, whether inert materials or biomaterials, such as cells in suspension cell culture. The methods and systems comprise use of an apparatus comprising a rotating chamber wherein the actions of the combined forces of gravity, fluid flow force and centrifugal force form a fluidized bed within the rotating chamber.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: February 19, 2019
    Assignee: Sartorius Stedim North America Inc.
    Inventors: Sunil Mehta, Tod Herman, Harold Ross, Khurshid Iqbal, Joe McMahon
  • Patent number: 10208284
    Abstract: Provided is a device for seeding cells in a plurality of cell arrangement areas in a simple manner and a short period of time. A seeding and culturing device (1) for cells capable of forming a nerve network, the device comprising a cell-culturing substrate (2) having a plurality of cell arrangement areas (8) enclosed by a plurality of projecting parts, and a flow channel substrate (3) arranged on the cell-cultivating substrate (2) and having a plurality of through-holes (14), wherein the through-holes (14) are configured so as to provide flow channels in which the upper surface side of the substrate is an entrance (15) and the lower surface side of the substrate is an exit, and the exit (16) of the flow channels is positioned above any of the cell arrangement areas.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 19, 2019
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventors: Tsuneo Urisu, Zhi-hong Wang, Hidetaka Uno, Yasutaka Nagaoka
  • Patent number: 10208285
    Abstract: Provided herein are T-cell receptor (TCR) fusion proteins (TFPs), T-cells engineered to express one or more TFPs, and methods of use thereof for the treatment of diseases, including cancer.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: February 19, 2019
    Assignee: TCR2 THERAPEUTICS INC.
    Inventors: Patrick Baeuerle, Gregory Sieczkiewicz, Robert Hofmeister
  • Patent number: 10208286
    Abstract: The present disclosure provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, the methods comprising culturing the precursor cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist (and, in particular embodiments, one or more growth factors) that support the proliferation but not differentiation of the non-terminally differentiated cells. The present disclosure further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the disclosure can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: February 19, 2019
    Assignee: Fred Hutchinson Cancer Research Center
    Inventor: Irwin D. Bernstein
  • Patent number: 10208287
    Abstract: An object of the present invention is to provide a myocardial progenitor cell that is specifically induced to differentiate into a cardiomyocyte, and a method for preparing the myocardial progenitor cell. A method for preparing a CD82-positive cell includes, in sequence, a step (a) of obtaining stem cells, a step (b) of subjecting the stem cells to induction treatment of differentiation into cardiovascular cells, and a step (c) of separating, from the stem cells having been subjected to the induction treatment of differentiation in the step (b), a CD82-positive cell being negative for at least one cell surface marker selected from CD73, CD44, CD105, CD121a, CD18, and CD120a. This method enables preparation of a CD82-positive cell for use as a myocardial progenitor cell.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: February 19, 2019
    Assignee: iHeart Japan Corporation
    Inventors: Jun Yamashita, Masafumi Takeda
  • Patent number: 10208288
    Abstract: The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: February 19, 2019
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Patent number: 10208289
    Abstract: A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: February 19, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: André A. Adams, Michael Daniele, Frances S. Ligler
  • Patent number: 10208290
    Abstract: Provided herein are recombinant virion arrays comprising human membrane bound proteins that retain their native conformations and/or interactions, recombinant HSV-1 virions, and methods of use including high-content, high-throughput assays for screening for ligands and/or drugs that bind human membrane bound proteins, diagnostic assays, proteomic assays, and biosensor assays. Also provided are recombinant HSV-1 virions comprising an envelope comprising a plurality of heterologous membrane bound proteins that retain their native conformations and/or interactions as well as recombinant HSV-1 bacterial artificial chromosome (BAC) clones encoding heterologous membrane polypeptides.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: February 19, 2019
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Heng Zhu, Prashant Desai, Min Li, Shaohui Hu
  • Patent number: 10208291
    Abstract: Polybrene as an additive in cell culture medium is used in methods for the generation of high-titer hepatitis E virus stocks and assays for titration of hepatitis E virus. A cell culture medium containing polybrene is used for high-titer HEV generation, a method for determining the presence and/or the level of HEV in a sample, and an HEV titration assay using polybrene.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: February 19, 2019
    Assignee: GRIFOLS, S.A.
    Inventors: Brett Buno, Terri Journigan, Joann Hotta, Michael Burdick
  • Patent number: 10208292
    Abstract: Methods and compositions for increasing the production of recombinant proteins by introducing ICP0 to cells capable of producing a recombinant protein are encompassed. In one method, the recombinant protein is a protein that is required for the replication of a replication defective virus, wherein the recombinant protein is provided to the replication defective virus in trans.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: February 19, 2019
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Simon Delagrave, CharChang Lai
  • Patent number: 10208293
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a mutant AROM polypeptide and/or mutant catechol-O-methyltransferase polypeptide alone or in combination with one or more vanillin biosynthetic enzymes or UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce vanillin or vanillin beta-D-glucoside.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: February 19, 2019
    Assignees: International Flavors & Fragrances Inc., Evolva SA
    Inventors: Joergen Hansen, Esben Halkjaer Hansen, Honey Polur, Joseph M. Sheridan, Jonathan R. Heal, William D. O. Hamilton
  • Patent number: 10208294
    Abstract: The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: February 19, 2019
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Mathew Rude, Na Trinh, Andreas Schirmer, Jacob Gano
  • Patent number: 10208295
    Abstract: The present invention provides, among other things, methods of treating phenylketonuria (PKU), including administering to a subject in need of treatment a composition comprising an mRNA encoding phenylalanine hydroxylase (PAH) at an effective dose and an administration interval such that at least one symptom or feature of PKU is reduced in intensity, severity, or frequency or has delayed in onset. In some embodiments, the mRNA is encapsulated in a liposome comprising one or more cationic lipids, one or more non-cationic lipids, one or more cholesterol-based lipids and one or more PEG-modified lipids.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: February 19, 2019
    Assignee: Translate Bio, Inc.
    Inventors: Frank DeRosa, Michael Heartlein, Anusha Dias
  • Patent number: 10208296
    Abstract: The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: February 19, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Antonio Iavarone, Anna Lasorella, Raul Rabadan
  • Patent number: 10208297
    Abstract: Isolated polypeptides with lipase activity; polynucleotides encoding the polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the polypeptides for cleaning are disclosed.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: February 19, 2019
    Assignee: Novozymes A/S
    Inventors: Ming Li, Tianqi Sun, Xianzhi Jiang, Lone Baunsgaard, Carsten Hoerslev Hansen, Kim Borch, Han Bucong
  • Patent number: 10208298
    Abstract: A composition is disclosed that comprises at least one protein component of an RNA-guided endonuclease (RGEN) and at least one cell-penetrating peptide (CPP), wherein the RGEN protein component and CPP are covalently or non-covalently linked to each other in an RGEN protein-CPP complex. The RGEN protein-CPP complex can traverse (i) a cell membrane, or (ii) a cell wall and cell membrane, of a cell. The RGEN protein component of an RGEN protein-CPP complex in certain embodiments can be associated with a suitable RNA component to provide an RGEN capable of specific DNA targeting. Further disclosed are compositions comprising at least one protein component of a guide polynucleotide/Cas endonuclease complex and at least one CPP, as well as methods of delivering RGEN proteins into microbial cells, as well as methods of targeting DNA with RGENs.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: February 19, 2019
    Assignee: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Ryan L. Frisch, Xiaochun Fan, Seung-Pyo Hong, Ethel Noland Jackson
  • Patent number: 10208299
    Abstract: Recombinant human alpha glucosidase (rhGAA) composition derived from CHO cells that contains a more optimized glycan composition consisting of a higher amount of rhGAA containing N-glycans carrying mannose-6-phosphate (M6P) or bis-M6P than conventional rhGAAs, along with low amount of non-phosphorylated high mannose glycans, and low amount of terminal galactose on complex oligosaccharides. Compositions containing the rhGAA, and methods of use are described.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: February 19, 2019
    Assignee: Amicus Therapeutics, Inc.
    Inventors: Russell Gotschall, Hung V. Do
  • Patent number: 10208300
    Abstract: A process for preparing Streptomyces koganeiensis ATCC 31394 hyaluronidase by obtaining hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: February 19, 2019
    Assignee: FIDIA FARMACEUTICI S.P.A.
    Inventors: Luciano Messina, Susanna Vaccaro, Salvatore Caruso, Giovanni Gennari
  • Patent number: 10208301
    Abstract: The present invention relates to xylanase variants, polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; compositions comprising the xylanase variants and methods of using the variants.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: February 19, 2019
    Assignee: Novozymes A/S
    Inventors: Steffen Danielsen, Peter Kamp Hansen, Frank Winther Rasmussen, Roland Alexander Pache
  • Patent number: 10208302
    Abstract: A composite material includes: an apatite crystal in the form of a tube; and a functional component accommodated in the apatite crystal tube and constituted by a material having physical properties different from those of the apatite crystal. The apatite crystal may be a monocrystal given by the general formula M25(PO4)3X, where M2 denotes at least one element selected from the group consisting of divalent alkali earth metals and Eu, and X denotes at least one element or molecule selected from the group consisting of halogens and OH.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: February 19, 2019
    Assignee: KOITO MANUFACTURING CO., LTD.
    Inventors: Kiminori Enomoto, Hisayoshi Daicho, Yu Shinomiya
  • Patent number: 10208303
    Abstract: A solid-core ring-magnet having one or more cavities is provided. The magnet can have an overall cylindrical shape or a rectangular-prism shape. In either case, a portion of cavity walls of the magnet are ring shaped, causing the magnetic field lines to emanate from the magnet in the shape of a ring. The diameter of the ring shaped cavities can be constant throughout, constant through a portion of the cavity, variant throughout, or variant through a portion of the cavity. The cavities open to the end of the magnet, and terminate toward the core of the magnet. Also provided are systems and kits having solid-core ring-magnets. Methods of purifying a macromolecule using the solid-core ring-magnets are also provided.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: February 19, 2019
    Assignee: Alpaqua Engineering, LLC
    Inventor: Olaf Stelling
  • Patent number: 10208304
    Abstract: Described herein is a method that generally includes infecting a host cell with a rescue adenovirus, wherein the rescue adenovirus genome comprises a loxP site and encodes at least one marker, and wherein the host cell comprises a library of polynucleotides that complement the adenovirus genome marker and encode a detectable polypeptide; incubating the infected host cell under conditions effective to permit recombination between the adenovirus genome and one or more of the library polynucleotides and the production of recombinant adenovirus particles comprising at least on detectable polypeptide; and detecting the at least one detectable polypeptide. Also described are adenovirus libraries constructed using such a method.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: February 19, 2019
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Masato Yamamoto, Yoshiaki Miura
  • Patent number: 10208305
    Abstract: Methods relating to obtaining libraries of YY1-binding long non-coding RNAs, libraries obtained thereby, and methods of use thereof.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: February 19, 2019
    Assignee: The General Hospital Corporation
    Inventors: Jeannie T. Lee, Yesu Jeon
  • Patent number: 10208306
    Abstract: This disclosure relates to methods for promoting bone formation or reducing bone destruction. This disclosure also relates to methods for promoting the recruitment of mesenchymal stem cells (MSC) to a local site of injury or surgical intervention in bone to promote healing. In addition, this disclosure relates to methods for reducing or preventing mineral formation or bone growth, or reducing bone mass. The methods disclosed herein are useful for treating conditions such as osteoradionecrosis.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: February 19, 2019
    Assignee: The Research Foundation for the State University of New York
    Inventors: Nikhil A. Thakur, Bryan S. Margulies
  • Patent number: 10208307
    Abstract: The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: February 19, 2019
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Tracy Zimmermann, Amy Chan, Vasant Jadhav, Martin Maier, Kallanthottathil G. Rajeev
  • Patent number: 10208308
    Abstract: The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flue infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and prevention orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: February 19, 2019
    Assignee: Socpra Sciences Sante Et Humaines S.E.C.
    Inventors: Martin Richter, Richard Leduc, Eloic Colombo, Eric Marsault
  • Patent number: 10208309
    Abstract: The present invention relates to a novel siRNA, and a high-efficiency double-stranded oligo RNA structure containing the same, and a nanoparticle containing the high-efficiency double-stranded oligo RNA structure. The double-stranded oligo RNA structure has a structure in which a hydrophilic material and a hydrophobic material are conjugated to both ends of a double-stranded oligo RNA (siRNA) via a simple covalent bond or linker-mediated covalent bond in order to be efficiently delivered into cells, and may be converted into a nanoparticle form in an aqueous solution by hydrophobic interactions of double-stranded oligo RNA structures. It is preferable that the siRNA contained in the double-stranded oligo RNA structure is an siRNA specific for fibrosis or respiratory disease-related gene, particularly, amphiregulin or stratifin.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: February 19, 2019
    Assignee: BIONEER CORPORATION
    Inventors: Jeiwook Chae, Pyoung Oh Yoon, Boram Han, Mi Na Kim, Youngho Ko, Han Oh Park
  • Patent number: 10208310
    Abstract: TNF? antisense oligonucleotides are provided herein. Methods of treating TNF? diseases or disorders using the TNF? antisense oligonucleotides and related products are provided.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: February 19, 2019
    Assignee: Exicure, Inc.
    Inventors: Christopher C. Mader, Tiffany L. Halo, Sergei Gryaznov, Richard Kang, Weston Daniel
  • Patent number: 10208311
    Abstract: Methods for controlling obesity using minimally-invasive procedures including introducing embolic crystal particles that are naturally occurring and mostly non-toxic salts into the arterial capillaries feeding the sections of the stomach where the appetite inducing hormone, ghrelin, is produced to limit the blood flow to the region reducing appetite; introducing a virus vector or antisense oligonucleotide to inhibit the production of ghrelin and reduce the appetite; and introducing a soluble embolic particle with a virus vector or antisense oligonucleotide which will inhibit the flow of blood initially and then dissolve and release the inhibit vector to the region, generating ghrelin to control the appetite.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: February 19, 2019
    Inventor: Mubin I. Syed