Abstract: The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.

Abstract: The present invention concerns dosages for treatment of human cancer patients with an anti-Epidermal Growth Factor Receptor (EGFR) antibody.

Abstract: The present disclosure generally relates to chimeric antigen receptors, more specifically to chimeric antigen receptor compositions and methods for use of the same. The present disclosure also provides for nucleic acid molecules and expression vectors for making and using the chimeric antigen receptors and for co-receptor signaling using such chimeric antigen receptors. The present disclosure also provides methods of treatment using such compositions. The chimeric antigen receptors of the present disclosure interact with the endogenous T-cell receptor complex enabling physiological control of signaling and T-cell response and can be combined with ligands such as co-stimulatory ligands for further controlling and influencing T-cell activation and response.

Abstract: The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating the risk of brain relapse in such patients.

Abstract: The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.

Abstract: A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.

Abstract: Polypeptides are provided that are capable of significantly inhibiting and/or neutralizing P. aeruginosa. The polypeptides comprise two or more immunoglobulin single variable domains that are directed against the PcrV protein of P. aeruginosa, wherein the “first” immunoglobulin single variable domain and the “second” immunoglobulin single variable domain have different paratopes.

Abstract: Provided is a carboxymethyl cellulose or a salt thereof, in which when the carboxymethyl cellulose or the salt thereof is used as a binding agent for an electrode of a nonaqueous electrolyte secondary battery, defects, such as pinholes, on a surface of the electrode are reduced and a battery including the electrode has a good capacity retention. A method for producing a carboxymethyl cellulose or a salt thereof includes an alkali cellulose formation step (step 1) of allowing cellulose and an alkali to react with each other in the presence of a mixed solvent containing water and an organic solvent, an etherification step (step 2) of allowing the resulting alkali cellulose and an etherifying agent to react with each other, a purification step (step 3) of washing and drying the resulting reaction mixture, and a pulverization step (step 4) of pulverizing the resulting purified product.

Abstract: The present disclosure provides methods for functionalizing the surfaces of cellulose nanoparticles. In embodiments, nanoparticles are aerosolized, and then passed through a flow reactor where they are contacted with gaseous reactants to functionalize the surface of the nanoparticles. In other embodiments, the nanoparticles are aerosolized, and then passed through a plasma reactor where they are contacted with gaseous reactants to functionalize the surface of the nanoparticles. Once the functionalized nanoparticles are produced, they may be combined with polymers to form polymer composites having both a polymer and the functionalized nanoparticles. Systems for producing these functionalized nanoparticles, coupled with downstream polymer processing equipment for forming the polymer composites, are also provided.

Abstract: The present invention is directed to a method of making a functionalized elastomer, comprising the step of polymerizing monomers comprising a conjugated diene monomer in the presence of a lanthanide-based coordination polymerization catalyst activated with a magnesium compound of formula 1 Q-R1—Mg—R1-Q??1 where R1 is phenylene, or a linear or branched alkane diyl group containing 2 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing 1 to 10 carbon atoms; Q is of formula 2 or 3 —S—R2??2 where R2 is phenyl, or a linear or branched alkyl group containing 2 to 10 carbon atoms; where R3 and R4 are independently phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms, or R2 and R3 taken together with the nitrogen atom represent a nitrogen containing heterocyclic group containing from 4 to 12 carbon atoms.

Abstract: The present invention relates generally to a highly-hydrolyzed polyvinyl alcohol composition having increased cold-water solubility, a process for making such a polyvinyl alcohol composition, and various end uses thereof.

Abstract: A method for manufacturing a filter membrane for inhibiting microorganisms includes the following steps: obtaining a nano-zinc precursor and dissolving it into water, adding at least one reducing agent and interfacial agent to the water, thereby reducing zinc ions of the nano-zinc precursor to zinc particles so as to form liquid having nano-zinc particles; respectively placing the liquid having nano-zinc particles and a polymer material into plastic masterbatch process equipment, respectively volatilizing the fluid having nano-zinc particles and polymer material through the plastic masterbatch process equipment, performing air extraction and mixing by the plastic masterbatch process equipment, and adding at least one grafting agent to perform a mixed graft link, allowing the nano-zinc particles and polymer material to be linked together stably so as to form a plastic masterbatch having nano-zinc particles; and making the plastic masterbatch into a filer membrane through film making equipment.

Abstract: A process for the preparation of an ethylene polymer including the step of polymerizing ethylene or copolymerizing ethylene and one or more other olefins in the presence of a Phillips-type chromium catalyst in a gas-phase polymerization reactor containing a reactor bed of particulate polymer, wherein the gas-phase polymerization reactor is equipped with a cycle gas line, wherein the reactor gas returned to the polymerization reactor through the cycle gas line has been condensed in part and the amount of liquid in the returned reactor gas is from 0.5 wt. % to 10 wt. % based upon the total weight of the reactor gas/liquid composition, the polymerization is carried out at from 108° C. to 125° C., and an aluminum alkyl is fed into the polymerization reactor in an amount in the range of from 0.0025 mole to 0.1 mole per ton of dosed ethylene.

Abstract: Disclosed herein are ethylene-based polymers produced using dual metallocene catalyst systems. These polymers have low densities, high molecular weights, and broad molecular weight distributions, as well as having the majority of the long chain branches in the lower molecular weight component of the polymer, and the majority of the short chain branches in the higher molecular weight component of the polymer. Films produced from these polymers have improved impact and puncture resistance.

Abstract: A catalyst for the homopolymerization or copolymerization of CH2?CHR olefins, made from or containing the product obtained by contacting: (i) a solid catalyst component made from or containing Ti, Mg, Cl, and an internal electron donor compound, wherein the solid catalyst component contains from about 0.1 to about 50 wt % of Bi, based upon the total weight of the solid catalyst component; (ii) an alkyl aluminum compound and, (iii) an external electron donor compound having the formula: (R1)aSi(OR2)b wherein R1 and R2 are independently selected from the group consisting of alkyl radicals with 1-8 carbon atoms and a is 0 or 1 and a+b=4.

Abstract: The present invention relates to a vinyl chloride-based polymer composition and a method for producing the same, and more particularly, to a vinyl chloride-based polymer composition including a vinyl chloride-based polymer and a plasticizer, wherein the vinyl chloride-based polymer includes a higher fatty acid having 10 to 18 carbon atoms in an amount of more than 0.05 parts by weight to less than 2.0 parts by weight, based on 100 parts by weight of the vinyl chloride-based polymer.

Abstract: The present invention is directed to a stereoregular functionalized elastomer represented by poly(M1 co M2), wherein the functionalized elastomer comprises a microstructure selected from the group consisting of microstructures having at least 90 percent by weight of monomer residues in trans 1,4-configuration, and microstructures having at least 80 percent by weight of monomer residues in cis 1,4-configuration; wherein M1 is selected from the group consisting of isoprene and 1,3-butadiene; and M2 is of formula 4 wherein R6 is a covalent bond, phenylene, a linear or branched alkane diyl group containing 1 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing 1 to 10 carbon atoms; R7 is hydrogen or a linear or branched alkyl group containing 1 to 10 carbon atoms; X1 is selected from formulas 5 and 6 wherein R8 and R9 are independently trialkylsilyl, phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms,

Abstract: A polypropylene composition made from or containing: A) from 50 wt % to 90 wt %; of a propylene homopolymer; B) from 10 wt % to 50 wt %; of a copolymer of propylene having from 30.0 wt % to 70.0 wt %, of ethylene derived units, based upon the total weight of the copolymer; the sum of the amount of component A) and B) being 100; the polypropylene composition having: i) an intrinsic viscosity of the fraction soluble in xylene at 25° C. between 2.2 to 4.0 dl/g; ii) a MFR L (Melt Flow Rate according to ISO 1133, condition L, at 230° C. and 2.16 kg load) from 0.5 to 100 g/10 min; iii) a xylene soluble fraction ranging from 20 wt % to 50 wt %, based upon the total weight of the polypropylene composition; wherein the polypropylene composition being obtained by a polymerization process wherein the catalyst system contains bismuth.

Abstract: The present invention is directed to a method of making an amine functionalized elastomer, comprising the steps of polymerizing at least one first monomer selected from the group consisting of 1,3-butadiene and isoprene and a second monomer of formula I in the presence of a polymerization catalyst in a hydrocarbon solvent to form a first copolymer in solution; where R1 is phenylene, a linear or branched alkane diyl group containing from 1 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing from 1 to 10 carbon atoms; and R2 is methyl or ethyl; and mixing the first copolymer in solution with a protic solvent followed by stirring to convert the first copolymer to a second copolymer given by the formula poly(M1 co M2) wherein M1 is the first monomer and M2 is of formula II where R1 is as previously defined.

Abstract: The present invention is directed to functionalized elastomer given by the formula poly(M1 co M2) wherein M1 is a first monomer selected from the group consisting of 1,3-butadiene and isoprene and M2 is of formula II where R1 is phenylene, a linear or branched alkane diyl group containing from 1 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing from 1 to 10 carbon atoms.

Abstract: Aspects of the present invention relate to polymers, and particularly to farnesene polymers functionalized with one or more oxirane groups and, optionally, one or more hydroxyl groups. According to one aspect of the invention, provided is an epoxidized and optionally hydroxyl-functionalized polyfarnesene. The epoxidized farnesene polymer has at least one of a side chain or a main backbone functionalized with at least one oxirane group and, optionally, at least one terminal end functionalized with a hydroxyl group. In accordance with another aspect of the invention, a method is provided for preparing an epoxidized and optionally hydroxyl-functionalized polyfarnesene. The method includes epoxidizing a farnesene polymer, which may optionally contain one or more terminal hydroxyl groups, to functionalize at least one of a side chain or a main backbone of the farnesene polymer with an oxirane group.

Abstract: Methods of preparing macromonomers, e.g., single- or double-tailed macromonomers, using radical polymerization of a first monomer in solution or in an emulsion are described. Methods of using the macromonomers in the preparation of multigraft copolymers are also described. For instance, the macromonomer prepared by radical polymerization can be used in an emulsion copolymerization with a second monomer to form a random multigraft copolymer. The random multigraft co-polymers can be superelastomers.

Abstract: A resin blend is provided including a blend of resorcinol diphthalonitrile ether resin and a bisphenol M diphthalonitrile ether resin. Another resin blend is provided including a blend of resorcinol diphthalonitrile ether resin and a bisphenol T diphthalonitrile ether resin. The resin blends prior to cure have more favorable processing and curing properties compared to the resorcinol diphthalonitrile resin alone, enabling greater ease in manufacturing.

Abstract: The present invention provides a moisture-curable hot melt urethane composition, including a hot melt urethane prepolymer (A) having an isocyanate group and a foaming agent composition (B) containing N,N?-dinitrosopentamethylenetetramine (b1), urea (b2) and a polyol (b3). The present invention also provides a method for producing a foamed and cured product of a moisture-curable hot melt composition, which includes heat-melting a hot melt urethane prepolymer (A), then mixing the foaming agent composition (B) therewith, applying the resultant mixture to a substrate, and performing a heating treatment at a temperature equal to or higher than heat-melting temperature of the (A) to thereby cause foaming and curing. An object of the present invention is to provide a solvent-free foaming system, according to which a foamed and cured product with excellent texture can be obtained, and an excellent foamed state can be maintained even in a thin film.

Abstract: A polymer is represented by Formula (I): wherein X is a substituted or unsubstituted C2-C5 alkylene, alkenylene, or alkynylene group; Y is a substituted or unsubstituted divalent C2-C5 aliphatic hydrocarbyl group; Z is a divalent binding group; k is in a range from 0 to 3; m is in a range from 7 to 100; p is in a range from 0 to 30; n is in a range from 0 to 3; and q is in a range from 3 to 50. The polymer is used as a nucleating agent for PET resin.

Abstract: The present invention relates to a process for producing a diblock copolymer comprising the reaction of at least one aromatic polyester having a melting point in the range from 160° C. to 350° C. and at least one polymer diol having a melting point of less than 100° C. at a temperature of greater than 200° C. to obtain a mixture (G-a); and the reaction of the mixture (G-a) with at least one diisocyanate, wherein the diisocyanate is employed in a molar amount of at least 0.9 based on the alcohol groups of the polymer diols. The present invention further relates to diblock copolymers obtained or obtainable according to such a process and to the use of such diblock copolymers for producing extruded, injection molded and pressed articles and also foams, cable sheaths, hoses, profiles, drive belts, fibers, nonwovens, films, moldings, plugs, housings, damping elements for the electricals industry, automotive industry, mechanical engineering, 3-D printing, medicine and consumer goods.

Abstract: The present invention relates to a thermoplastic polyurethane composition imparted with crosslinking sites, which comprise a thermoplastic polyurethane containing crosslinking sites incorporated into the molecule of a polyol and/or a chain extender. The thermoplastic polyurethane composition has an easy-to-process viscosity at a processing temperature of about 130° C. or below in a low-temperature foaming process that is performed using an existing EVA crosslinking/foaming system. Thus, the thermoplastic polyurethane composition may be easily mixed with a crosslinking agent, a foaming agent and various additives, and when it is press-molded or injection-molded to provide a crosslinked foam, foam cells are easily formed by the crosslinking sites incorporated into the molecule of the polyol and/or the chain extender.

Abstract: Disclosed are methods for designing a polyisocyanurate foam-forming composition with good low temperature insulation performance. The methods include: (a) measuring the LTTR of a first polyisocyanurate faced foam laminate prepared from a first polyisocyanurate foam-forming composition comprising a blowing agent composition comprising one or more hydrocarbon blowing agents with an atmospheric pressure boiling point of at least 68° F. (20° C.

Abstract: The present disclosure provides: an epoxy resin molding material including; an epoxy resin having a mesogen structure, a phenolic curing agent, an inorganic filler, and a curing accelerator having a quaternary phosphonium cation represented by the following Formula (I); a molded product and a molded cured product using the epoxy resin molding material; and a method for producing a molded cured product. In Formula (I), each of Ra to Rd independently represents an alkyl group having from 1 to 6 carbon atoms, or an aryl group, and the alkyl group and the aryl group may have a substituent.

Abstract: There is provided an oligomeric polyol composition having (a) an oligomeric network containing residues of at least one polyhydroxylated aromatic compound and residues of at least one polyol having at least three hydroxyl groups; and (b) a plurality of peripheral groups having one or more pendant hydroxyl groups bound to the oligomeric network by a plurality of linking units. The residues of the polyol may optionally contain one or more oxygen ether groups, one or more amino ether groups, or both of one or more oxygen ether groups and one or more amino ether groups. Reaction of the oligomeric polyols with isocyanate monomers affords a new class of polyurethanes having superior heat and water resistance. The new polyurethanes exhibit lower peak exotherms, typically less than 250° F. during in-mold polymerization.

Abstract: There is provided an oligomeric polyol composition having (a) an oligomeric network containing residues of at least one polyhydroxylated aromatic compound and residues of at least one polyol having at least three hydroxyl groups; and (b) a plurality of peripheral groups having one or more pendant hydroxyl groups bound to the oligomeric network by a plurality of linking units. The residues of the polyol may optionally contain one or more oxygen ether groups, one or more amino ether groups, or both of one or more oxygen ether groups and one or more amino ether groups. Reaction of the oligomeric polyols with isocyanate monomers affords a new class of polyurethanes having superior heat and water resistance. The new polyurethanes exhibit lower peak exotherms, typically less than 250° F. during in-mold polymerization.

Abstract: A conducting polymer which may have one redox couple and/or enhanced redox capacity. The polymer is a copolymer prepared by electropolymerizing a mixture of monomers.

Abstract: A polyoxalate copolymer including an acid-constituting unit derived from an oxalic acid and a diol-constituting unit derived from a diol component, the diol-constituting unit being derived from a combination of an ethylene glycol and other diols, and having a temperature differential between a 5% weight loss temperature as measured by the TG-DTA and a melting point thereof in a range of 50 to 80° C.

Abstract: The present invention relates to a polyester resin. The polyester resin is useful for bottles, sheets, multilayer sheets, stretched films and fiber applications due to excellent heat resistance and transparency, and in particular, the polyester resin has little deterioration of physical properties such as yellowing, etc.

Abstract: A process for producing a ?-amino ester functionalized oligomer or polymer, said process comprising the steps of: providing a polyol represented by the formula A-(OH)q wherein q?2 and A denotes an oligomeric or polymeric backbone, and converting said polyol into its corresponding acetoacetate functionalized compound by transacetoacetylation with an acetoacetate reagent; and, subjecting said acetoacetate functionalized compound to either indirect amination or direct reductive amination. Said indirect amination may be characterized by comprising the steps of: converting the acetoacetate functionalized compound into its corresponding enamine by reaction with at least one amine bearing at least a primary or secondary amine group; and, reducing the enamine product of the previous step to form the corresponding ?-amino ester functionalized compound.

Abstract: The present invention provides a polycarbonate resin containing a repeating unit represented by formula (A) in the amount of 1-99.5 wt %, the polycarbonate resin also containing an oligomer having a specific structure in a total amount that constitutes a content of 2.5 wt % or lower. (In formula (A), R1 and R2 each independently represent a hydrogen atom, a phenyl group, a C1-6 alkyl group, or a C1-6 alkyloxy group).

Abstract: The present invention relates to the field of polymerisation catalysts, and systems comprising these catalysts for polymerising carbon dioxide and an epoxide, a lactide and/or lactone, and/or an epoxide and an anhydride. The catalyst is of formula (I): wherein at least one of M1 or M2 is selected from Ni(II) and Ni(III)-X. A process for the reaction of carbon dioxide with an epoxide; an epoxide and an anhydride; and/or a lactide and/or a lactone in the presence of the catalyst is also described.

Abstract: A method for producing polyethylene glycol having a terminal carboxyl group including oxidizing polyethylene glycol represented by formula (I): CH3O(CH2CH2O)n(CH2)m—CHO with potassium peroxymonosulfate in water whose pH is adjusted to be from 6 to 8 with at least one selected from a carbonate, a phosphate, a citrate and an acetate at 5 to 40° C. to produce polyethylene glycol represented by formula (II): CH3O(CH2CH2O)n(CH2)m—COOH, wherein n is a number from 10 to 1,100, and m is 2 or 3.

Abstract: The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.

Abstract: A sulfonyl-substituted polyphenylene-ether polymer having improved dielectric properties and methods for making the same. The sulfonyl-substituted PPE include sulfone-containing polyphenylene oxides (“PPO”) polymers having repeating units of the formulas: wherein each of R1 and R2 is H or an alkyl group containing from 1 to 4 carbon atoms, R3 is an alkylene group containing from 1 or 2 carbon atoms, R4 is selected from a group consisting of an alkyl group containing from 1 to 4 carbon atoms, an aryl group, and CF3, and X is a halogen atom. The subscript n is 0 or 1; the subscript m is 1 or 2, provided that when m is 2, R2 is H. A degree of polymerization ranges from about 5 to about 1,000, and a ratio of units having formula (1) to units having formula (2) of the sulfone-containing PPO polymer ranges from about 10:90 to about 90:10.

Abstract: The present invention relates to a polyamide molding compound comprising the following components or consisting of these components: (A) 40 to 95 wt % of a specific polyamide mixture consisting of the polyamides (A1) and (A2); (B) 5 to 50 wt % of at least one glass filler having a refractive index in the range from 1.540 to 1.600; (C) 0 to 10 wt % of at least one additive; wherein the weight proportions of the components (A) to (C) add up to 100% wt %; wherein the at least one transparent polyamide (A2) has a transparency of at least 90% and a haze of at most 3%. The present invention additionally relates to molded bodies composed of this polyamide molding compound.

Abstract: A novel polymer having high glass transition temperature and an excellent balance between heat resistance, high refractive index and mechanical properties, and a composition and molded article containing the polymer are provided. The polymer according to the invention has a first structural unit represented by at least one of formulae (1-1), (1-2) and (1-3) below and a second structural unit having either a secondary amino structure or a tertiary amino structure at two or more terminals.

Abstract: The present invention provides a method for producing granular polyarylene sulfide (PAS) with increased average particle size and enhanced particle strength, a method for increasing the average particle size of granular PAS, a method for enhancing the particle strength of granular PAS, and granular PAS.

Abstract: A resin composition capable of forming a cured film having a high refractive index, high transparency and high heat resistance, and a polymer which is used for the resin composition. A polymer having a structural unit of Formula (1): wherein A1 and A2 are each independently an —O— group or a —C(?O)O— group; X is a divalent organic group having at least one aromatic ring or heterocyclic ring, wherein, when the X has two or more aromatic rings or heterocyclic rings, the rings are optionally bonded to each other via a single bond, are optionally bonded to each other via a heteroatom, or optionally form a condensed ring; and Y is a divalent organic group having at least one aromatic ring or condensed ring. A resin composition, includes: the polymer; a cross-linking agent; and a solvent.

Abstract: The invention pertains to a polyarylether sulfone polymer [polymer (PAES)] incorporating recurring units derived from well-defined amount of bi- or poly-functional monomers having identical functionalities in each of their reactive groups in a chain of units derived from of a monohalo-monohydroxyl arylsulfone monomer comprising groups of formula (A), free from hydroxyl groups which are bound to a phenyl ring comprising an activating —SO2— group in para-position, while comprising an activated aromatic halogen bound to a phenyl ring comprising an activating —SO2— group in para-position, having improved balance between mechanical properties and viscosity in the molten state, and endowed by lower polydispersity indexes with respect to materials of the prior art, to a method for making the same, to polymer compositions comprising the same, and to shaped articles therefrom.

Abstract: The present invention encompasses materials and methods for catalyzing the cross-linking and curing of siloxane polymers. In particular, the present disclosure provides materials, methods, and conditions for vapor phase catalysis for curing organosiloxane polymers and resins, including resin linear organosiloxane block copolymers, as well as the incorporation of those methods into processes for making light emitting devices, including light emitting diodes.

Abstract: The use of an N-acylaminoacid condensate as a surfactant in the preparation of silicone rubber particle emulsions allows the emulsions to be prepared with exceptionally low levels of surfactants. The resulting rubber particles display typical silicone rubber characteristics in contrast to rubber particles prepared using larger amounts of conventional surfactants.

Abstract: Inhibited tin or titanate catalysts are used in condensation cures of silicone materials. Such catalysts are command cure systems with long open pot life, yet have relatively fast cure when the cure mechanism is triggered. This combines the advantages of the inhibited addition cure systems (command cure) with the advantages of the condensation cure systems (lower cost).

Abstract: A method for preparing silicone elastomers containing hydrophobic skin actives with excellent characteristics is described. The elastomer shows enhanced efficacy with respect to the skin actives compared to skin care compositions formulated with individual elastomer and active(s) components. Skin care compositions containing the inventive silicone elastomers and methods of skin treatment are also described.

Abstract: A composite silicone rubber particle is disclosed, wherein a part or entire surface of the silicone rubber particle is covered by a fine particle, a surface of which is modified by a functional group containing quaternary ammonium salt. Manufacturing methods of the composite silicone rubber particle are also disclosed, as well as a cosmetic product composition containing the composite silicone rubber particle. The composite silicone rubber particle has hydrophilicity and dispersibility while maintaining excellent fluidity, contains no harmful methanol, and has antimicrobial activity.