Patents Issued in February 21, 2019
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Publication number: 20190055166Abstract: The invention relates to a copper-ceramic composite, comprising a ceramic substrate, which contains aluminum oxide, a coating on the ceramic substrate made of copper or a copper alloy, wherein the aluminum oxide has an average grain form factor Ra(Al2O3), determined as an arithmetic average value from the form factors of the grains of the aluminum oxide, the copper or the copper alloy has an average grain form factor Ra(Cu), determined as an arithmetic average of the form factors of the grains of the copper or copper alloy, and the average grain form factors of the aluminum oxide and copper or copper alloy meet the following condition: 0.5?Ra(Al2O3)/Ra(Cu)?2.0.Type: ApplicationFiled: February 16, 2017Publication date: February 21, 2019Inventors: Kai Herbst, Christian Muschelknautz, Alexander ROGG
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Publication number: 20190055167Abstract: The invention relates to a copper-ceramic composite comprising: a ceramic substrate containing alumina; a copper or copper alloy coating on the ceramic substrate; the alumina has a mean grain shape factor Ra(Al2O3), defined as the arithmetic mean of the shape factors R of the alumina grains, of at least 0.4.Type: ApplicationFiled: February 16, 2017Publication date: February 21, 2019Applicant: Heraeus Deutschland GmbH & Co. KGInventors: Kai Herbst, Chrisitan Muschelknautz
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Publication number: 20190055168Abstract: Compositions including a biochar, and related methods are described herein. The composition can be produced by contacting a biomass with a pretreatment agent including an alkali metal or an alkaline earth metal to form a pretreated biomass, and pyrolyzing the pretreated biomass under conditions sufficient to form a biochar. A related method includes contacting soil with the composition thereby increasing a soluble plant available silicon content in the soil.Type: ApplicationFiled: August 17, 2018Publication date: February 21, 2019Inventors: Jim Jian Wang, Meng Wang
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Publication number: 20190055169Abstract: The invention relates to a synergistic mixture of urease inhibitor and nitrification inhibitor for the treatment of urea-containing fertilizers, more particularly having an improved urease-inhibitory effect, to the use thereof, and to urea-containing fertilizers comprising said mixture.Type: ApplicationFiled: June 22, 2016Publication date: February 21, 2019Inventors: Nils PETERS, Thomas MANNHEIM
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Publication number: 20190055170Abstract: Flares with consumable weights connected to a forward end of the grain of the flare are disclosed. Also disclosed are consumable weight components for flares. The consumable weight components include a metal material within a matrix. Also disclosed are methods for fabricating a flare and methods for using a flare. Use of the consumable weights in the flares may reduce the amount of debris falling to ground.Type: ApplicationFiled: October 24, 2018Publication date: February 21, 2019Inventors: Jeffrey F. Widener, Daniel B. Nielson
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Publication number: 20190055171Abstract: The invention is directed to a radiation curable energetic composition, to a method of forming a three-dimensional energetic object, to a three-dimensional energetic object, and to uses of the radiation curable energetic composition. The radiation curable energetic composition of the invention comprises (a) one or more polymerisable components, (b) one or more polymerisation photoinitiators, and (c) one or more energetic components.Type: ApplicationFiled: March 22, 2017Publication date: February 21, 2019Applicant: Nederlandse Organisatie voor toegepast-natuurweten schappelijk onderzoek TNOInventors: Michiel Hannes STRAATHOF, Christoffel Adrianus VAN DRIEL, Aafke Tessa TEN CATE
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Publication number: 20190055172Abstract: A process of converting a carbon-carbon double bond on a substrate into a cyclopropane ring, which method comprises the step of treating the substrate with a N-alkyl-N-nitroso compound, a transition metal catalyst and an aqueous base, wherein the N-alkyl-N-nitroso compound is formed by reacting an alkyl amine with an alkali metal nitrite in the presence of a mono-basic or di-basic acid, or a mixture thereof, and wherein the N-alkyl-N-nitroso compound is not distilled before it is mixed with the substrate, catalyst and base.Type: ApplicationFiled: September 14, 2016Publication date: February 21, 2019Inventors: Fridtjof SCHRÖDER, Marcel STECK
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Publication number: 20190055173Abstract: A process for decomposing a hydrocarbon-containing composition includes feeding the hydrocarbon-containing composition to a reactor containing a catalytically active molten metal or a catalytically active molten metal alloy, wherein the metal or alloy catalyzes a decomposition reaction of the hydrocarbon-containing composition into a hydrogen-rich gas phase and a solid carbon phase. The solid carbon phase is insoluble in the metal or alloy. The process may be a continuous process.Type: ApplicationFiled: August 21, 2017Publication date: February 21, 2019Applicant: Palo Alto Research Center IncorporatedInventors: Divyaraj Desai, Jessica Louis Baker Rivest
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Publication number: 20190055174Abstract: A method for producing a conjugated diene according to an aspect of the present invention comprises a step of contacting a raw material gas containing an alkane with a dehydrogenation catalyst to obtain a product gas containing at least one unsaturated hydrocarbon selected from the group consisting of an olefin and a conjugated diene. In the production method, the dehydrogenation catalyst is a catalyst having a supported metal containing a Group 14 metal element and Pt supported on a support containing Al and a Group 2 metal element; the dehydrogenation catalyst has pores (a) having a pore diameter of 7 nm or more and 32 nm or less; and a proportion of a pore volume of the pores (a) is 65% or more of the total pore volume of the dehydrogenation catalyst.Type: ApplicationFiled: March 10, 2017Publication date: February 21, 2019Applicant: JXTG NIPPON OIL & ENERGY CORPORATIONInventors: Tatsuya ICHIJO, Nobuhiro KIMURA
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Publication number: 20190055175Abstract: Processes, systems, and catalysts for the conversion of 2-butene to 1,3-butaidene without the use of steam or, in some embodiments, with a reduced use of steam as compared to prior art processes are provided. The catalyst includes tungsten trioxide (WO3) on an inorganic support includes activated magnesium oxide (MgO) and may be referred to as a “dual catalyst” or a “co-catalyst.” Embodiments of the catalyst. A process for the production of 1,3-butadiene may include contacting a feed stream of 2-butene with a WO3-inorganic support catalyst or a MgO and WO3-inorganic support catalyst and may be performed without steam in the feed stream.Type: ApplicationFiled: August 16, 2017Publication date: February 21, 2019Inventors: Faisal H. Alshafei, Miao Sun, Munir D. Khokhar, Zhonglin Zhang, Sohel K. Shaikh, Mark P. Kaminsky
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Publication number: 20190055176Abstract: The invention concerns a process for oxidative dehydrogenation of ethane. In the process an ethane comprising stream is fed to a distillation column to remove propane. The purified ethane stream is subjected to oxidative dehydrogenation using a catalyst comprising Mo/V/Sb, or Mo/V/Nb and Te or Sb in the orthorhombic M1 crystalline phase. The reactor effluent comprises ethylene. The effluent is washed with water to remove acetic acid. The acetic acid is recovered from the aqueous stream by means of solvent extraction.Type: ApplicationFiled: October 25, 2016Publication date: February 21, 2019Inventors: Georgios MITKIDIS, Maria SAN ROMAN MACIA, Guus VAN ROSSUM, Ronald Jan SCHOONEBEEK
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Publication number: 20190055177Abstract: Processes and associated reaction systems for the oxidative dehydrogenation of an alkane containing 2 to 6 carbon atoms, preferably ethane or propane, more preferably ethane, are provided. In particular, a process is provided that comprises supplying a feed gas comprising the alkane and oxygen to a reactor vessel that comprises an upstream and downstream catalyst bed; contacting the feed gas with an oxidative dehydrogenation catalyst in the upstream catalyst bed, followed by contact with an oxidative dehydrogenation/oxygen removal catalyst in the downstream catalyst bed, to yield a reactor effluent comprising the alkene; and supplying an upstream coolant to an upstream shell space of the reactor vessel from an upstream coolant circuit and a downstream coolant to a downstream shell space of the reactor vessel from a downstream coolant circuit.Type: ApplicationFiled: February 23, 2017Publication date: February 21, 2019Inventors: Alouisius Nicolaas Renée BOS, Guus VAN ROSSUM, Ronald Jan SCHOONEBEEK, Michael Johannes Franciscus Maria VERHAAK
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Publication number: 20190055178Abstract: This disclosure relates to processes, compositions, and systems useful for the oxydehydrogenation of alkanes to form olefins (e.g., for the conversion of ethane to ethylene). The processes use an oxygen transfer agent and may be carried out in any suitable reactor, including a reverse flow reactor, a circulating fluid bed reactor, or a cyclic co-flow reactor.Type: ApplicationFiled: August 13, 2018Publication date: February 21, 2019Inventors: Brian M. Weiss, ChangMin Chun, Dhaval A. Bhandari, Federico Barrai, Sophie Liu
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Publication number: 20190055179Abstract: Provided are a compound and a fragrance composition that are excellent in harmony with various other fragrance materials and can be blended to impart a natural and fresh floral feeling. The present invention provides a cyclopropane compound represented by Formula (I) and a fragrance composition containing a cyclopropane compound represented by Formula (I): where R1 is a methyl group and R2 is a methyl group, or R1 is a hydrogen atom and R2 is an ethyl group.Type: ApplicationFiled: October 28, 2016Publication date: February 21, 2019Applicant: Kao CorporationInventors: Junko Ueda, Naotashi Toki, Takahiro Asada, Makiko Sato
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Publication number: 20190055180Abstract: Provided are a bisphenol represented by the general formula (1), a method for producing the bisphenol, and a polyarylate resin, a (meth)acrylate compound and an epoxy resin which are derived from the bisphenol. In the formula (1), R1 to R4 are the same or different, and each represent an alkyl group, an aryl group or a halogen atom, n1 and n2 are the same or different, and each represent an integer of 1 to 4, and k1 to k4 are the same or different, and each represent 0 or an integer of 1 to 4. When at least one of k1 to k4 is 2 or more, corresponding R1 to R4 may be the same or different.Type: ApplicationFiled: January 25, 2017Publication date: February 21, 2019Applicant: TAOKA CHEMICAL CO., LTD.Inventors: Yuji NISHIDA, Takafumi SAIKI, Ayumi MATSUSHIMA, Hideki MORIO, Yuka MORINAGA, Yoshinori KAWAMURA
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Publication number: 20190055181Abstract: A method of making spirogalbanone includes the steps of: (a) subjecting ethynylspirodecanol to a Rupe rearrangement to give a compound of the formula I (b) converting the compound of (a) to a C1-C4 alkyl acetal; (c) subjecting the acetal to a trans-acetalisation reaction with allyl alcohol in the presence of a mild acid catalyst; (d) heating the product of (c) in the presence of an acid catalyst to give an allylenolether; and (e) subjecting the product of (d) to a Claisen rearrangement to give spirogalbanone. The method affords an easier and more efficient method of preparation.Type: ApplicationFiled: February 13, 2017Publication date: February 21, 2019Inventors: Simon ELLWOOD, William Alexander THIAM
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Publication number: 20190055182Abstract: This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I): comprising treating a compound of formula (II) or (III): with a palladium (II) catalyst under alkylation conditions.Type: ApplicationFiled: October 22, 2018Publication date: February 21, 2019Inventors: Brian M. Stoltz, Alexander N. Marziale, Robert A. Craig, Douglas Duquette, Kelly E. Kim, Marc Liniger, Yoshitaka Numajiri
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Publication number: 20190055183Abstract: A process for producing acetic acid is disclosed in which the recycle ratio of the mass flow of the light liquid phase recycled to the reactor to the mass flow of the aqueous recycle stream recycled to the reactor is less than or equal to 2.Type: ApplicationFiled: October 2, 2015Publication date: February 21, 2019Inventors: Ronald D. SHAVER, Yaw-Hwa LIU, Mark O. SCATES
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Publication number: 20190055184Abstract: Processes for purifying acetic acid by distilling a process stream in a column in which acetic anhydride is formed in the lower portion of the column. The product stream withdrawn from the column comprises acetic acid, water at a concentration of no more than 0.2 wt. %, and acetic anhydride at a concentration of no more than 600 wppm. The process further comprises hydrating the acetic anhydride in the product stream to form a purified acetic acid product comprising acetic anhydride at a concentration of no more than 50 wppm.Type: ApplicationFiled: October 19, 2018Publication date: February 21, 2019Inventors: Ronald D. SHAVER, Yaw-Hwa LIU, Mark O. SCATES
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Publication number: 20190055185Abstract: A treatment method of at least partially removing impurities from a composition containing a fluorine-containing organic acid having the carbon number of 2 to 7 and impurities, the method including a flocculant mixing step of mixing the composition and a flocculant; and a separating step of separating a mixed phase obtained at the mixing step into a solid phase and a liquid phase.Type: ApplicationFiled: October 13, 2016Publication date: February 21, 2019Applicant: DAIKIN INDUSTRIES, LTD.Inventors: Mihoko OHASHI, Shuji ITATANI, Atsuko TAI
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Publication number: 20190055186Abstract: Provided is a method for extracting a 1,5-pentanediamine from a solution system containing a 1,5-pentanediamine salt. The method comprises adding to the solution system an insoluble basic substance to form a solution system containing free 1,5-pentanediamine. The provided method has high applicability, is easy to use, and is environmentally-friendly, significantly lowering raw material costs and operating costs for the entire manufacturing process. The method achieves a high recovery rate for pentanediamine, and is more suitable for industrial-scale production.Type: ApplicationFiled: September 7, 2016Publication date: February 21, 2019Applicants: Cathay R&D Center Co., Ltd., Cathay Industrial Biotech Ltd.Inventors: Xiucai Liu, Bingbing Qin, Chen Yang
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Publication number: 20190055187Abstract: An amine-based compound represented by Formula 1, in which one of R1 to R10 is a group represented by Formula 2, and an organic light-emitting device including the same are provided: When the amine-based compound is included in an organic light-emitting device as a hole transport material, the device may exhibit excellent I-V-L characteristics, including a low driving voltage, improved efficiency, and improved lifespan.Type: ApplicationFiled: January 12, 2018Publication date: February 21, 2019Inventors: Jongwoo Kim, Jangyeol Baek, Eunjae Jeong, Sanghyun Han, Youngkook Kim, Seokhwan Hwang
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Publication number: 20190055188Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.Type: ApplicationFiled: February 23, 2017Publication date: February 21, 2019Inventors: Edmond J. LaVoie, Ajit Parhi, Gifty A. Blankson, Liping Wang, Xiao Chen, Yongzheng Zhang, Malvika Kaul, Daniel S. Pilch
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Publication number: 20190055189Abstract: Disclosed is a process for preparing ?-agonist, 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino) ethanol, of Formula I. The process comprises refluxing 1-(4-amino-3,5-dichlorophenyl) ethanone of Formula II and selenium dioxide in the presence of 1,4-dioxane to form compound of Formula III. Further, compound of Formula III is heated at a temperature below 30° C. in the presence of t-butyl amine to form compound of Formula IV. The compound of Formula IV is treated with sodium borohydride to form compound of Formula I.Type: ApplicationFiled: August 4, 2016Publication date: February 21, 2019Inventors: G. Pratap REDDY, M. Kesava REDDY
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Publication number: 20190055190Abstract: The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester Acid Salts, as described below) that can be used to prepare PNA monomers wherein said PNA monomers can be used to prepare said PNA oligomers. In some embodiments, the disclosure features sulfonic acid salts of Backbone Ester compounds, which sulfonic acid salts generally tend to be crystalline and can be obtained in reasonably good yield, often without requiring any chromatographic purification of the reaction product of the Backbone Ester synthesis reaction. This disclosure also pertains to novel methods for the synthesis of said Backbone Ester compounds and novel methods for the formation of the related sulfonic acid salts.Type: ApplicationFiled: July 17, 2018Publication date: February 21, 2019Inventors: James M. Coull, Brian D. Gildea
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Publication number: 20190055191Abstract: The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, containing a compound represented by Formula (I), an enantiomer thereof, a diastereomer thereof, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: January 26, 2017Publication date: February 21, 2019Applicant: TOHOKU UNIVERSITYInventors: Shigeki MORIGUCHI, Koji FUKUNAGA, Yoshiharu IWABUCHI
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Publication number: 20190055192Abstract: This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject including, inter alia, hormone-related conditions, bone-related disorders, and muscle wasting diseases and/or disorders.Type: ApplicationFiled: July 20, 2018Publication date: February 21, 2019Inventors: James T. Dalton, Duane D. Miller
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Publication number: 20190055193Abstract: Substituted hydroquinones and quinones and methods of synthesizing such compounds are disclosed herein. The substituted hydrroquinones have the formula: while the substituted quinones have the corresponding oxidized structure (1,4-benzoquinones). One, two, three, or all four of R1, R2, R3 and R4 comprise a thioether moiety and a sulfonate moiety, and wherein each R1, R2, R3 and R4 that does not comprise a thioether and a sulfonate moiety sulfonate moiety is independently a hydrogen, an alkyl or an electron withdrawing group. The substituted hydroquinones and quinones are soluble in water, stable in aqueous acid solutions, and have a high reduction potential in the oxidized form. Accordingly, they can be used as redox mediators in emerging technologies, such as in mediated fuel cells or organic-mediator flow batteries.Type: ApplicationFiled: October 3, 2018Publication date: February 21, 2019Inventors: Shannon S. Stahl, James B. Gerken
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Publication number: 20190055194Abstract: The present application relates to novel azetidinimine of formula (I). Wherein R1-R6 are as defined in claim 1. The azetidinimine of the invention are useful as antibiotics and as inhibitors of a carbapenemases. The present invention thus further relates to their use in antibiotic therapies and their methods of synthesis.Type: ApplicationFiled: September 7, 2016Publication date: February 21, 2019Inventors: Robert Dodd, Kevin Cariou, Corinne Minard, Bogdan-Iuliu Iorga, Thierry Naas
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Publication number: 20190055195Abstract: The invention pertains to the creation of two new classes of compounds, referred to as “phenyl, bromo-maleimide acids” and “Phenyl, bromo-maleimide amines”, which are derivatized from the maleimide, C2H2(CO)2NH (2,5-pyrroledione) and have the backbone structure of formula I and II below, where n is 0-6. In the maleimide ring, a hydrogen in the 3,4-imide (C2H2) is substituted by a bromide and the nitrogen is bonded to a phenyl group, which is bonded to a carboxylic acid or amine. The invention also pertains to the use of these two classes of compounds to tag molecules with a Br,Ph-maleimide group or to synthesize hetrobifunctional linkers with a Br,Ph-maleimide group for conjugating various molecules to the sulfhydryl groups of cysteine residues in proteins, peptides, nanoparticles, or cells.Type: ApplicationFiled: July 9, 2018Publication date: February 21, 2019Applicant: Immunwork Inc.Inventors: Tse-Wen CHANG, Hsing-Mao CHU
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Publication number: 20190055196Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological conditions.Type: ApplicationFiled: August 22, 2018Publication date: February 21, 2019Inventors: Maria A. Argiriadi, Eric C. Breinlinger, Kevin P. Cusack, Adrian D. Hobson, Dominique Potin, Martine Barth, Jerome Amaudrut, Olivia Poupardin, Laurent Mounier, Michael E. Kort
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Publication number: 20190055197Abstract: The present solution relates to crystalline modifications of methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate salts of Formula I, wherein HX represents at least one acid component, preferably methanesulfonic acid, p-toluenesulphonic acid, L-tartaric acid, maleic acid, acetic acid and phosphoric acid. Another solution also relates to the processes for the preparation thereof as well as said use thereof in pharmaceutically acceptable compositions. Use of said crystalline forms of intedanib and manufactured salts in the preparation of methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate in the form of any pharmaceutically acceptable salt thereof is also object of this invention.Type: ApplicationFiled: February 20, 2017Publication date: February 21, 2019Applicant: Zentiva k.s.Inventors: Eszter TIEGER, Marcela TKADLECOVA, Ondrej DAMMER, Tomas GURGUT
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Publication number: 20190055198Abstract: Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1?), as well as hypoxia inducible factor-2 (HIF-2). Also disclosed herein are pharmaceutical compositions comprising one or more of the disclosed compounds. Yet further disclosed are methods for stimulating the cellular immune response in a mammal such as increasing phagocytosis, for example, prolonging the life of phagocytes, inter alia, kerotyiocytes, neutrophils. As such the disclosed compounds provide methods for treating diseases that relate to the body's immune response.Type: ApplicationFiled: February 20, 2018Publication date: February 21, 2019Inventors: Joseph H. Gardner, Robert Shalwitz
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Publication number: 20190055199Abstract: Provided is a compound showing excellent Antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused by Trichophyton fungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH2, C?O, NH, O, S or the like; X1, X2 and X3 are CR1 or N; Y is CH or N; Z is CR2b or N; R2a and R2b are each a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group, a C1-C6 haloalkyl group or the like; R2a and R2b may form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.Type: ApplicationFiled: September 14, 2016Publication date: February 21, 2019Applicant: KAKEN PHARMACEUTICAL CO., LTD.Inventors: Atsushi WATANABE, Yuuki SATO, Keiji OGURA, Yoshiyuki TATSUMI
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Publication number: 20190055200Abstract: The present invention relates to a catalytic process for preparing pyrazoles comprising the step of cyclizing hydrazone substituted ?,?-unsaturated carbonyl compounds by reacting them with hydrogen in a reaction mixture comprising as components (a) a hydrogenation catalyst, (b) an acid selected from Brønsted acids, ammonium salts of Brønsted acids, and Lewis acids, (c) a protic solvent, and optionally (d) an aprotic solvent.Type: ApplicationFiled: January 25, 2017Publication date: February 21, 2019Inventors: Eric George KLAUBER, Michael RACK, Sebastian SOERGEL, Birgit GOCKEL, Roland GOETZ
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Publication number: 20190055201Abstract: A method for producing a compound (4), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific chiral ligand and a ruthenium catalyst, or in the presence of an asymmetric transition metal complex catalyst previously generated from the chiral ligand and the ruthenium catalyst.Type: ApplicationFiled: October 22, 2018Publication date: February 21, 2019Inventors: Masaki HAYASHI, Kazutoshi UKAI
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Publication number: 20190055202Abstract: The present disclosure provides pyrimidine compounds of Formula 1 and uses thereof for example, for the potential treatment of diseases associated with P2X purinergic receptors. In certain aspects, the present disclosure provides P2X3 and/or P2X2/3 antagonists which are useful, for example, for the potential treatment of visceral organ, cardiovascular and pain-related diseases, conditions and disorders.Type: ApplicationFiled: March 20, 2017Publication date: February 21, 2019Applicant: Afferent Pharmaceuticals Inc.Inventors: Ronald Charles Hawley, Prabha Ibrahim, Anthony P. Ford, Joel R. Gever
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Publication number: 20190055203Abstract: Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.Type: ApplicationFiled: October 22, 2018Publication date: February 21, 2019Inventors: Ernst Schönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence
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Publication number: 20190055204Abstract: Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.Type: ApplicationFiled: August 21, 2018Publication date: February 21, 2019Inventors: Larry Wendell Hardy, Michele L.R. Heffernan, Frank Xinhe Wu, Lakshmi D. Saraswat, Kerry L. Spear
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Publication number: 20190055205Abstract: The present disclosure relates to novel synthetic method of making 1, 4-diazo N-heterocycles via intermolecular amphoteric diamination of allenes, and to the compounds made by the novel synthetic method.Type: ApplicationFiled: July 13, 2018Publication date: February 21, 2019Applicant: Purdue Research FoundationInventors: Mingji Dai, Zhishi Ye
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Publication number: 20190055206Abstract: A polyester resin composition containing 100 parts by mass of a polyester resin and 0.01 to 10 parts by mass of a 2-amino-1,3,5-triazine derivative of Formula [1]: a polyester resin molded body obtained by the composition, and a crystal nucleating agent including the triazine derivative. A polyester resin composition containing a crystal nucleating agent that makes it possible to produce, with high productivity, a polyester resin molded product that promotes polyester resin crystallization and maintains high transparency after crystallization and is applicable for a wide variety of uses can be provided.Type: ApplicationFiled: October 24, 2018Publication date: February 21, 2019Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Takuma NAGAHAMA, Takeshi SUWA
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Publication number: 20190055207Abstract: Provided is a method for producing flutemetamol including the steps of: reacting a precursor compound represented by a predetermined general formula with a radioactive fluoride to obtain a 18F labeling compound represented by a predetermined general formula; allowing a strong base to act on the reaction mixture of the above step containing the precursor compound and the 18F labeling compound; after the above step, purifying the 18F labeling compound using a reverse phase solid phase extraction cartridge; and removing a protective group to obtain [18F]flutemetamol.Type: ApplicationFiled: October 17, 2016Publication date: February 21, 2019Applicants: GE Healthcare Limited, Nihon Medi-Physics Co., Ltd.Inventors: Yuki Okumura, Gota Tonoya, Tomoyuki Matsunami
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Publication number: 20190055208Abstract: Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.Type: ApplicationFiled: August 17, 2018Publication date: February 21, 2019Inventors: Brian K. Shoichet, Anat Levit, Aashish Manglik, Brian Kobilka, Peter Gmeiner, Harald Hübner, Daniela Gisela Dengler
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Publication number: 20190055209Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.Type: ApplicationFiled: October 24, 2018Publication date: February 21, 2019Applicant: The Board of Trustees of the University of IllinoisInventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
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Publication number: 20190055210Abstract: An object of the present invention is to provide a photocuring method, which makes it possible to rapidly and efficiently obtain a crosslinked product (resin), a compound used in the photocuring method, and a photocuring resin composition containing the compound. The present invention relates to a photocuring method, which comprises a step 1 and a step 2 performed after the step 1, a compound used in the photocuring method, and a photocuring resin composition containing the compound. Step 1: this is a step in which in the presence of (A) compound having a carbonyl group generating a radical by photoirradiation and a carboxyl group decarboxylated by photoirradiation, (B) silane coupling agent having a mercapto group or a (meth)acryl group is reacted with (C) water under acidic conditions to obtain (D) silane compound having a mercapto group or a (meth)acryl group and at least one silanol group.Type: ApplicationFiled: January 25, 2017Publication date: February 21, 2019Applicant: FUJIFILM Wako Pure Chemical CorporationInventors: Nobuhiko SAKAI, Kosuke YANABA, Shigeaki IMAZEKI, Koji ARIMITSU
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Publication number: 20190055211Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, stereoisomer or prodrug thereof, wherein A, R1, R3a, R3b, R4a, R4b, G2, G3, G4, m1, m2, m3, m4, L1, L2 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.Type: ApplicationFiled: September 28, 2016Publication date: February 21, 2019Inventors: Liansheng Li, Jun Feng, Yun Oliver Long, Yuan Liu, Pingda Ren, Yi Liu
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Publication number: 20190055212Abstract: This disclosure relates to compounds that inhibit histone demethylase activity. In particular, the disclosure relates to compounds that inhibit histone lysine demethylase KDM5B, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions disclosed herein.Type: ApplicationFiled: February 16, 2017Publication date: February 21, 2019Inventor: Stephen Gwaltney
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Publication number: 20190055213Abstract: A compound of Formula I: or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.Type: ApplicationFiled: March 8, 2017Publication date: February 21, 2019Applicant: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.Inventors: Adrianus Petrus Antonius DE MAN, Joost Cornelis Marinus UITDEHAAG, Jan Gerard STERRENBURG, Joeri Johannes Petrus DE WIT, Nicole Wilhelmina Cornelia SEEGERS, Antonius Maria VAN DOORNMALEN, Rogier Christian BUIJSMAN, Guido Jenny Rudolf ZAMAN
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Publication number: 20190055214Abstract: The invention provides—opioid receptor agonists that are analgesic agents and that promote diminished side effects relative to a comparably effective dose of morphine. The side effects that are absent or attenuated include one or more of the following: constipation, respiratory depression, tolerance, dependence, nausea, confusion, sedation, hypotension, and post-treatment withdrawal symptoms.Type: ApplicationFiled: March 15, 2017Publication date: February 21, 2019Inventors: Thomas D. Bannister, Laura M. Bohn, Cullen L. Schmid
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Publication number: 20190055215Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.Type: ApplicationFiled: September 29, 2016Publication date: February 21, 2019Applicants: ASTEX THERAPEUTICS LIMITED, CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Gianni CHESSARI, Steven HOWARD, Ildiko Maria BUCK, Benjamin David CONS, Christopher Norbert JOHNSON, Rhian Sara HOLVEY, David Charles REES, Jeffrey David ST.DENIS, Emiliano TAMANINI, Bernard Thomas GOLDING, Ian Robert HARDCASTLE, Celine Florence CANO, Duncan Charles MILLER, Martin Edward Mäntylä NOBLE, Roger John GRIFFIN, James Daniel OSBORNE, Joanne PEACH, Arwel LEWIS, Kim Louise HIRST, Benjamin Paul WHITTAKER, David Wyn WATSON, Dale Robert MITCHELL