Abstract: A fluorescent imaging device for plaque monitoring enables fluorescent imaging in a normal environment other than a dark room, thereby preventing inconvenience for both a medical staff and a patient due to the dark room. Also, a carotid artery plaque can be monitored in greater detail and in a short time by means of generating and combining a fluorescent image and a photo-acoustic image.

Abstract: There is provided a medical observation device including: an imaging control unit configured to control an imaging device with a plurality of light sources that emit light having different wavelengths. The imaging control unit controls light emission of the plurality of light sources so that intensity of light emitted by the light source having a shortest wavelength out of intensity of light at a reference color temperature is greater than intensity of light emitted at the reference color temperature. The reference color temperature is a reference color temperature used to display a medical captured image captured by the imaging device.

Abstract: An endoscope includes: an aperture portion having an opening to which light from an observation target site is incident; a filter unit that has a plurality of filters and selectively transmits light based on any one of the filters; a color separation prism that is formed by a plurality of separation prisms which separate light, which has transmitted through the filter unit, into beams of light having different color components from each other; a plurality of image sensors that are provided so as to respectively correspond to the separation prisms and capture an image based on the beams of light; a signal output unit that outputs image signals captured by the image sensors respectively; and a filter disposing unit that disposes any one of the plurality of filters so that the light is incident to the disposed one of the plurality of filters.

Abstract: [Object] To propose an endoscope light source capable of making an area of a region to be irradiated with illumination light changeable, a control method of an endoscope light source, and an endoscope apparatus using such an endoscope light source. [Solution] An endoscope light source according to the present disclosure includes: a light source section that emits light from at least one or more solid light sources; a coupling section capable of connecting with a light guide connected to an endoscope; and a control section that performs control so as to make an incident angle of a light ray that enters the light guide in the coupling section, changeable.

Abstract: A method is provided for reprocessing an internal channel of a medical device with a reprocessing system having a valve, a fluid line fluidly coupled with the valve, and at least one sensor coupled with the fluid line. The method includes performing an actuation of the valve to direct liquid through the fluid line and into the internal channel, and detecting with the at least one sensor a predetermined condition within the fluid line while the liquid is being directed into the internal channel. In response to detecting the predetermined condition, a time duration measured from the actuation of the valve is recorded. The method further includes purging the liquid from the internal channel, and directing liquid through the fluid line and into the internal channel for the time duration.

Abstract: A lightfield otoscope includes a housing with a tip configured to receive a disposable speculum. The otoscope also includes a microlens array, a sensor array and an optical train contained within the housing. The optical train includes an objective lens and a relay lens. The objective lens is positioned at least partially within the tip. The relay lens is used to relay an image plane of the objective lens to the microlens array and to relay a pupil plane of the objective lens to the sensor array. An active heating element is also contained within the housing and positioned to heat the front surface, thereby reducing fogging and/or condensation on the front surface.

Abstract: The invention relates to medical devices for carrying out internal examination, such as laryngoscopes. The laryngoscope is provided with a camera element within a channel inside the blade.

Abstract: An ophthalmologic apparatus according to an exemplary embodiment acquires data by OCT scanning of the anterior eye segment. The apparatus generates distribution information of a predetermined parameter in the anterior eye segment by analyzing the data. The apparatus acquires a front image of the anterior eye segment at the time of the data being acquired. The apparatus stores the first distribution information and the first front image both corresponding to the first time, and the second distribution information and the second front image both corresponding to the second time. The apparatus calculates the positional difference between the first front image and the second front image. The apparatus applies registration to the first distribution information and the second distribution information based on the positional difference.

Abstract: Interpupillary calibration system and method for stereoscopic visualization. The system includes a first display, second display, and calibration processor. The first display is disposed in proximity to a left aperture of an eyeframe to present a first image area through the left aperture, the first image area associated with an image and having a first display axis. The second display is disposed in proximity to a right aperture of the eyeframe to present a second image area through the right aperture, the second image area associated with the image and having a second display axis. The calibration processor is configured to adjust a display distance between the first image area and second image area based on an interpupillary distance of a user, wherein the first image area and second image area are visible through the first aperture and second aperture enabling formation of a stereoscopic view of the image.

Abstract: A method is disclosed, comprising obtaining a first angular offset between a first eye direction and a first gaze direction of an eye having a first pupil size, obtaining a second angular offset between a second eye direction and a second gaze direction of the eye having a second pupil size, and forming, based on the first angular offset and the second angular offset, a compensation model describing an estimated angular offset as a function of pupil size. A system and a device comprising a circuitry configured to perform such a method are also disclosed.

Abstract: An eye tracking system having circuitry configured to perform a method is disclosed. An estimated radius (r) from an eyeball center to a pupil center in an eye is obtained, and an estimated eyeball center position (e) in the eye in relation to an image sensor for capturing images of the eye is determined, and an image of the eye captured by means of the image sensor, and a position of a representation of the pupil center in the eye in the obtained image is identified. An estimated pupil center position (p?) is then determined based on the estimated eyeball center position (e), the estimated radius (r), and the identified position of the representation of the pupil center in the obtained image.

Abstract: A system for measuring eye tracking may include a chassis, which may include a main column and a head rest assembly. The head rest assembly may include a stimulus screen for displaying a video to the patient, an optical mirror, an eye tracking camera, and at least one head rest member for stabilizing the patient's head, relative to the stimulus screen. The system may also include: a base attached to a bottom of the main column to support the main column; an arm extending from the main column to support the head rest assembly; a touchscreen interface attached to the main column and configured to provide control of the system to a user; a camera computer housed in the main column for controlling the eye tracking camera; and a system computer housed in the main column for controlling the stimulus screen, data processing and other functions.

Abstract: A laser surgery system includes a light source, an eye interface device, a scanning assembly, a confocal detection assembly and preferably a confocal bypass assembly. The light source generates an electromagnetic beam. The scanning assembly scans a focal point of the electromagnetic beam to different locations within the eye. An optical path propagates the electromagnetic beam from a light source to the focal point, and also propagates a portion of the electromagnetic beam reflected from the focal point location back along at least a portion of the optical path. The optical path includes an optical element associated with a confocal detection assembly that diverts a portion of the reflected electromagnetic radiation to a sensor. The sensor generates an intensity signal indicative of intensity the electromagnetic beam reflected from the focal point location. The confocal bypass assembly reversibly diverts the electromagnetic beam along a diversion optical path around the optical element.

Abstract: A therapeutic methodology for improving eye contact in children with ASD. A plurality of pairs of contact lenses is provided to an adult, typically a therapist or a parent of a child, where the contact lenses have an image of a subject of interest to the child imprinted on the contact lens. The plurality of the pairs of contact lenses provides a series of pairs of contact lenses where the image is gradually faded. An adult interacting with the child begins by wearing contact lenses having an image of greatest intensity. Through a series of therapy sessions with the therapist uses the contact lenses, as the child's duration and frequency of eye contact improves, the therapist will then use lenses with the image of the subject of interest to the child that are gradually faded. When therapeutic goal of the targeted duration and frequency of eye contact is reached, therapy using the contact lenses can be terminated.

Abstract: Proposed is an ophthalmic lens doublet for indirect ophthalmoscopy. The doublet is cemented into an integral unit from two lens elements, of which is a convex-convex lens element and another is a convex-concave lens element. Both lens elements have external and internal surfaces and may be combined so that the ophthalmic lens doublet has asphericity either on one side or on both sides of the unit. The aspheric surface is characterized by asphericity Z of the following formula (1) Z=Y2/{R+[R2?(1+k)Y2]1/2}??(1), where Z is in one of coordinates in a Cartesian coordinate system, Y is a second coordinate in the Cartesian coordinate system, R and k being variable parameters which are different for each selected values of d, where d is an outer diameter of the ophthalmic lens doublet.

Abstract: An eye surgery visualization system includes an image sensor and contains an imaging system for producing an image of an object region with an optical imaging beam path in an imaging plane on an image sensor. A computer unit has an image processing routine for an image of the object region, the image having been captured by the image sensor. An image display unit visualizes image data of an image processed in the computer unit. An ophthalmoscopy loupe of the system images a portion lying within a patient's eye in an intermediate image plane that is conjugate to the imaging plane on the image sensor. The image processing routine separates the first portions of the image of the object region from second portions of the image of the object region in the imaging plane on the image sensor.

Abstract: A microfluidic strain sensing device for monitoring intraocular pressure. The device has a contact lens and a closed microfluidic network embedded with the contact lens. The network has a volume that is sensitive to an applied strain. The network distinguishes: (i) a gas reservoir containing a gas, (ii) a liquid reservoir containing a liquid that changes volume when the strain is applied, and (iii) a sensing channel able to hold the liquid within the sensing channel. The sensing channel connects the gas reservoir on one end and connects the liquid reservoir on another end. The sensing channel establishes a liquid-gas equilibrium pressure to interface and equilibrium within the sensing channel, which would fluidically change as a response to radius of curvature variations on a cornea, or as a response to mechanical stretching and release of the cornea. The liquid-gas equilibrium pressure interface and equilibrium are used for measuring the intraocular pressure.

Abstract: A transceiver for interfacing with an analyte sensor. The transceiver may include an interface device and a notification device. The interface device may be configured to convey a power signal to the analyte sensor and to receive data signals from the analyte sensor. The notification device may be configured to generate one or more of a vibrational, aural, and visual signal based on one or more data signals received from the analyte sensor. The interface device of the transceiver may receive analyte data from the analyte sensor, and the transceiver may comprise a processor configured to calculate an analyte concentration value based on the received analyte data. The notification device may be configured to generate one or more of aural, visual, or vibrational alarm when the calculated analyte concentration value exceeds or falls below a threshold value.

Abstract: Individuals who suffer from certain kinds of medical conditions, particularly conditions that only sporadically exhibit measurable symptoms, can feel helpless in their attempts to secure access to medical care because, at least in part, they are left to the mercy of their condition to present symptoms at the right time to allow diagnosis and treatment. Providing these individuals with ambulatory extended-wear health monitors that record ECG and physiology, preferably available over-the-counter and without health insurance preauthorization, is a first step towards addressing their needs. In addition, these individuals need a way to gain entry into the health care system once a medically-actionable medical condition has been identified. Here, the ECG and physiology is downloaded and evaluated post-monitoring against medical diagnostic criteria.

Abstract: A wearable patient device is provided that includes one or more sensors. The one or more sensors can record one or both of ECG information or phonocardiographic information. The sensor information can be used to determine the blood pressure of a monitored individual, including on a continuous basis. Blood pressure can be determined using one or both of a determined time to empty or fill one or more heart chambers or first and second blood velocities. Vital sign information can be provided to a monitoring individual, including graphical representations of trend information.

Abstract: A disease prediction apparatus may include: a spectrometer configured to obtain an optical spectrum of a subject; and a processor configured to predict autofluorescence of the subject based on the optical spectrum by applying the optical spectrum to an autofluorescence prediction model, and predict a risk of developing a cardiovascular disease based on the predicted autofluorescence.

Abstract: Methods and apparatuses for generating a model of a subject's teeth. Described herein are intraoral scanning methods and apparatuses for generating a three-dimensional model of a subject's intraoral region (e.g., teeth) including both surface features and internal features. These methods and apparatuses may be used for identifying and evaluating lesions, caries and cracks in the teeth. Any of these methods and apparatuses may use minimum scattering coefficients and/or segmentation to form a volumetric model of the teeth.

Abstract: A processing apparatus concerning medical images includes a reference image readout unit configured to read out a reference image acquired by photoacoustic imaging, a target image readout unit configured to read out a target image for diagnostics acquired by photoacoustic imaging, and a calculation unit configured to modify at least one of a read-out reference image and a read-out target image, wherein the reference image and the target image are read out while being associated with meta-information, and wherein the calculation unit modifies at least one of the read-out reference image and the read-out target image based on the meta-information.

Abstract: A plethysmographic respiration processor is responsive to respiratory effects appearing on a blood volume waveform and the corresponding detected intensity waveform measured with an optical sensor at a blood perfused peripheral tissue site so as to provide a measurement of respiration rate. A preprocessor identifies a windowed pleth corresponding to a physiologically acceptable series of plethysmograph waveform pulses. Multiple processors derive different parameters responsive to particular respiratory effects on the windowed pleth. Decision logic determines a respiration rate based upon at least a portion of these parameters.

Abstract: A flow rate control valve includes a bobbin and a plunger. On an inner circumferential surface of the bobbin, multiple protruding regions that extend in a direction parallel in an axial direction to the plunger, and a plurality of recessed grooves that form flow paths for a fluid when valve is open are provided side by side alternatingly in a circumferential direction. The multiple recessed grooves include a first recessed groove, second recessed groove, and third recessed groove that are arranged side by side sequentially in the circumferential direction. An interval in the circumferential direction between the first recessed groove and second recessed groove and an interval in the circumferential direction between the second recessed groove and third recessed groove are the same. Surfaces of the multiple protruding regions formed on the inner circumferential surface of the bobbin can be arranged at positions closer to those of one perfect circle.

Abstract: The invention provides systems and methods for monitoring the wellbeing of a fetus by the non-invasive detection and analysis of fetal cardiac electrical activity data.

Abstract: Disclosed herein are devices, systems, methods and platforms for continuously monitoring the health status of a user, for example the cardiac health status. The present disclosure describes systems, methods, devices, software, and platforms for continuously monitoring a user's health-indicator data (for example and without limitation PPG signals, heart rate or blood pressure) from a user-device in combination with corresponding (in time) data related to factors that may impact the health-indicator (“other-factors”) to determine whether a user has normal health as judged by or compared to, for example and not by way of limitation, either (i) a group of individuals impacted by similar other-factors, or (ii) the user him/herself impacted by similar other-factors.

Abstract: An apparatus for measuring bio-information in a non-invasive manner includes: a pulse wave sensor configured to measure a plurality of pulse wave signals having different wavelengths from an object; a contact pressure sensor configured to measure contact pressure of the object while the plurality of pulse wave signals are measured; and a processor configured to obtain an oscillometric waveform based on the contact pressure and the plurality of pulse wave signals having the different wavelengths, and obtain bio-information based on the oscillometric waveform.

Abstract: Wireless, variable inductance and resonant circuit-based vascular monitoring devices, systems, methodologies, and techniques are disclosed that can be used to assist healthcare professionals in predicting, preventing, and diagnosing various heart-related and other health conditions.

Abstract: This blood pressure/pulse wave measurement device obtains a pulse wave velocity (baPWV) that is an index representing the arterial stiffness of a subject. A lower limb/upper limb blood pressure ratio (ABI) that is an index representing the clogging of the blood vessels of a subject is obtained. When the lower limb/upper limb blood pressure ratio (ABI) of the subject surpasses a preset first threshold value, a point (Px) representing the pulse wave velocity (baPWV) is displayed on a one-dimensional graph (46). When the lower limb/upper limb blood pressure ratio (ABI) of the subject is equal to or less than the preset first threshold value, a point representing the lower limb/upper limb blood pressure ratio (ABI) is displayed on the one-dimensional graph (46) instead of the point representing the pulse wave velocity (baPWV).

Abstract: A system for facilitating measurement of a person's blood pressure having: a) a cuff that is configured to: i) be operatively situated in relationship to a person's arm; and ii) strategically exert different pressure on the person's arm to controllably restrict blood flow therein; and b) a base assembly that supports the cuff. The base assembly is configured to allow selective placement of the cuff in first and second different positions relative to the person with the person in a measurement taking position. The cuff in the first position is configured to be operatively situated in relationship to the person's left arm. The cuff in the second position is configured to be operatively situated in relationship to the person's right arm.

Abstract: A sensor element including a light source configured to emit light to the exterior of the sensor element, a light detector configured to detect light that enters the sensor element, and a window element that covers at least one of the light source and the light detector, wherein the window element comprises a plurality of adjacent optical fibers.

Abstract: Systems, methods, apparatuses, and non-transitory computer-readable media for micro and macro activity detection and monitoring are disclosed.

Abstract: Provided are a neural electrode for measuring a neural signal, and a method for manufacturing the same. The method for manufacturing the same includes forming an ITO electrode on a substrate, forming a passivation layer for exposing a portion of the ITO electrode, forming ITO nanowires on the ITO electrode, and forming a metal oxide on the ITO nanowires.

Abstract: A two-dimensional visual display that allows for the user and/or another individual, such as the user's spouse, to experience self-evident, abnormally complex elevated heart rate arrhythmia. The system of the present invention uses a heart rate monitor, along with data analysis, to provide the user with a visual display, seismic feel, and/or aural feedback that allow for the user to be quickly alerted as to any arrhythmia, thereby signaling to the user to change their activity in order to avoid sudden cardiac death.

Abstract: Method for determining positive entrainment sites for mapping active reentrant circuits, including the procedures of measuring a pre-entrainment cycle length at at least one cardiac site, measuring a post-pacing interval (PPI) at the cardiac site, determining a difference between the PPI and the pre-entrainment cycle length and annotating the cardiac site according to the determined difference.

Abstract: A myocardial excitation determining apparatus which can support the determination of excitation dynamics of the myocardium during atrial fibrillation is provided. A myocardial excitation determining apparatus has: an acquiring section 2 which acquires an intracardiac electrocardiogram of a subject; a processing section 3 which computes to produce visualized data indicating a state of excitation in the myocardium, based on the intracardiac electrocardiogram; and a determining section 4 which determines the type of excitation dynamics of the myocardium based on the visualized data.

Abstract: A myoelectricity measurement device includes a plurality of myoelectricity sensor electrodes, a measurement unit connectable to the plurality of myoelectricity sensor electrodes, and a control unit configured to select a first combination of at least three myoelectricity sensor electrodes to be connected to the measurement unit, designate a first electrode in the first combination as a reference electrode, a second electrode in the first combination as a first input electrode, and third electrode in the first combination as a second input electrode, acquire a first voltage difference between the first and second input electrodes in reference to a voltage of the reference electrode, the voltage difference, and select a second combination of at least three myoelectricity sensor electrodes to be connected to the measurement unit, at least one myoelectricity sensor electrode in the second combination being different from the myoelectricity sensor electrodes in the first combination.

Abstract: In some embodiments, the present application provides a swallowable capsule comprising pseudo conductive high-electron-mobility transistors (PC-HEMTs), and its use in an intestinal and gut diagnostics and gut motility monitoring.

Abstract: Electrocardiograms can be analyzed in the time-frequency domain, following conversion into time-frequency maps, to determine characteristics or features of various waveforms, such as waveform morphology and/or the amplitude(s) and location(s) (in time and/or frequency) of one or more extrema of the waveform. Based on comparison of the extrema against thresholds and/or against each other, disease conditions may be determined.

Abstract: Cardiac catheterization is carried out by inserting a multi-electrode probe into a heart of a living subject, preparing a current position map of the electrodes to define respective locations of the electrodes, and recording electrograms from the electrodes. Activation times are annotated at the respective locations by analysis of the electrograms and generating an activation map. A region of the activation map is selected and earliest ones of the activation times in the selected region identified. The earliest activation times are graphically indicated.

Abstract: Provided are systems, methods, and devices for closed loop control associated with brain activity. Systems may include an interface configured to obtain a plurality of measurements from a brain of a user, and a first processing device including one or more processors configured to generate a plurality of brain state parameters characterizing one or more features of at least one brain state of the user. The systems may also include, a second processing device including one or more processors configured to generate at least one model of the brain of the user based, at least in part, on the plurality of brain state parameters and the plurality of measurements. The systems may further include a controller including one or more processors configured to generate a control signal based on the plurality of brain state parameters and the at least one model.

Abstract: Determining the location of a body area network enabled device on a user's body and using the location information to determine whether to send instructions or data to the device over the body area network, includes integrating an EMG sensor into a device that is wearable or otherwise meant to be in contact with or close proximity to an intended area of a user's body. The integrated EMG sensor may detect the electrical potential of the user's body at the point of contact. Variance of electrical potential across the user's body may be used to determine information regarding the location of the sensor, and thus, the location of the device on the user's body. The location of the device, in turn, may be used to determine whether to send instructions or data to the device over the body area network.

Abstract: A method for detection of interference in impedance based monitoring of a subject by using a monitor is disclosed. The method comprising, connecting the subject to the monitor using one or more leads; and before current is applied to the subject, measuring voltage on the subject via at least one of the one or more leads and if any voltage is detected then the monitor indicates a warning. An impedance based monitor is disclosed, the monitor being connectable to a subject. The monitor is configured to measure voltage on the subject, before any current is applied to the subject, and if any voltage is detected then the monitor is configured to indicate a warning.

Abstract: Accuracy degradation due to a signal loss is reduced, and susceptibility is calculated with high accuracy where, by using an MRI, at least one echo is acquired where spatial magnetic field inhomogeneity is reflected, and a complex image is calculated from the acquired echo. Three masks are calculated from the calculated complex image; a low-signal region mask representing a low signal region, a first high-signal region mask representing a high signal and high fat content region, and a second high-signal region mask representing a high signal and low fat content region. In calculating a susceptibility image from a frequency image or a magnetic field image generated from the complex image, the susceptibility image is obtained under the constraint that a region defined by the low-signal region is set as a background and the susceptibility of the region defined by the second high-signal region mask is set to a specific value.

Abstract: A method is disclosed for adjusting a couch position, the method including: acquiring a user selection of a scanning protocol from a plurality of possible scanning protocols; acquiring a user input in respect of an isocenter position; acquiring a user input in respect of a focus position; displaying an overview of the body region to be examined, including a selection range and an indicator of the focus position relative to the body region, the selection range being displayable aligned with the focus position; acquiring a user input in respect of a changed focus position; aligning the selection range with the changed focus position; and adjusting the couch position to a focus couch position corresponding to the focus position upon the changed focus position meeting a test criterion, and adjusting to an isocenter couch position corresponding to the isocenter position upon the changed focus position not meeting the test criterion.

Abstract: A system and method for guiding the placement of a peripherally inserted central catheter in a patient is provided. The system includes a peripherally inserted central catheter; at least one sensor configured to be coupled to said catheter and structured to sense and transmit an electrical signal associated with a P wave; a data base including known data corresponding to standard and non-standard P waves including peaks, deflections and transition points; and a processing device in operable communication with said at least one sensor and said data base, said processing device configured to receive said electrical signal and identify P waveform attributes of said signal, cross-reference said waveform attributes and said electrical signal with known data in said base data, and output indicia representative of said P waveform attributes and said signal based on said cross-reference.

Abstract: Analysis of pulmonary scans representative of a patient's pulmonary structure can be used to classify a patient into one or more of a plurality of populations. The patient's scan can be mapped to a reference domain and analyzed to determine one or more fissure features associated with a plurality of regions in the reference domain. Comparison of the determined fissure features with a plurality of fissure atlases, each associated with different population, can be performed to classify the patient into one or more of the populations. Data from different fissure atlases can be compared to determine regions in the fissure atlases that distinguish one population from another. Such distinguishing regions can improve the ability to classify the patient while reducing errors based on false classifications.

Abstract: A device for measuring a component in exhaled breath comprising an inlet for receiving exhaled breath, a buffer chamber. A first fluid conduit is in fluid connection with the inlet and adapted to lead a first portion of the exhaled breath to the buffer chamber. The buffer chamber comprises an outlet for discarding a first part of exhaled breath received from the first fluid conduit and the buffer chamber is configured to buffer a second part of exhaled breath received from the first fluid conduit. The device comprises a second fluid conduit in fluid connection with the inlet and adapted to lead a second portion of the exhaled breath to be discarded, and a sensor for measuring a component in the exhaled breath buffered in the buffer chamber.

Abstract: The invention provides a multi-sensor system that uses an algorithm based on adaptive filtering to monitor a patient's respiratory rate. The system features a first sensor which is selected from the group consisting of an impedance pneumography sensor, an ECG sensor, a PPG sensor, and a motion sensor (e.g., an accelerometer) configured to attach to the patient's torso and measure therefrom a motion signal. The system further comprises (iii) a processing system, configured to operably connect to the first and motion sensors, and to determine a respiration rate value by applying filter parameters obtained from the first sensor signals to the motion sensor signals.