Abstract: Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles.

Abstract: Cell binding agent-drug conjugates comprising bridge linkers, and methods of using such linkers and conjugates are provided.

Abstract: The invention provides compositions comprising a carrier comprising a continuous phase of a hydrophobic substance, liposomes, and a polynucleotide, and methods for using such compositions for delivering a polynucleotide to a subject.

Abstract: Disclosed herein are compositions and methods for treating cancer in a subject. This involves administering an oncolytic virus containing a heterologous DNA sequence encoding one or more immunomodulatory and/or immunostimulatory polypeptide(s) of interest to the subject under conditions effective to enhance an anti-tumor immune response in the subject, and to treat cancer. It also relates to a method of enhancing the delivery to and distribution within a tumor mass of therapeutic viruses.

Abstract: A polyion complex of mRNA and a polycationic polymer, and a composition and a pharmaceutical composition for mRNA delivery are provided. The polyion complex of mRNA and the polycationic polymer can deliver mRNA into cells in the body of a subject almost without inducing inflammation. The polyion complex can then cause mRNA to be uniformly expressed in cells in the body of the subject. The pharmaceutical composition containing the polyion complex is suitable for use in treating a disease whose condition rapidly progresses or an acute disease.

Abstract: This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing same, and methods for gene replacement, gene therapy, gene transcription silencing, and the delivery of therapeutic proteins to tissue in vivo, comprising the molecules. The present invention also provides methods of reducing the immunogenicity of RNA, oligoribonucleotide, and polyribonucleotide molecules.

Abstract: The problem is to provide a method that can quickly and efficiently evaluate the toxicity of human cerebrospinal fluid (CSF) with small amounts of human CSF. The problem is solved by a method comprising administering human CSF into the cerebral ventricle of a rodent such as a mouse, and evaluating the cognitive function of the rodent by using a behavioral pharmacological technique.

Abstract: A filamentous plant virus carrier comprising a filamentous plant virus particle that has been modified to carry an imaging agent or cytotoxic compound is described. The filamentous plant virus carrier can be used in a method of targeting cancer cells and tissue by administering it to a subject. Cancer tissue targeted by the filamentous plant virus carrier can be imaged using an imaging agent, or treated using a cytotoxic compound.

Abstract: Urea-based photosensitizers, which target prostate-specific membrane antigen (PSMA) for imaging and targeted therapy of PSMA-expressing tumors and cancers are disclosed.

Abstract: The present disclosure provides functionalized magnetic nanoparticles (MNPs) comprising a functional group that binds to ?-amyloid deposits and/or neurofibrillary tangles. The present disclosure provides compositions comprising the functionalized MNPs, and methods of using the functionalized MNPs in imaging ?-amyloid deposits and neurofibrillary tangles.

Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable stereoisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable stereoisomers in solution useful as concentration independent CEST responsive agents.

Abstract: A freeze-dried powder composition comprising a phospholipid and a polyethylene glycol, said polyethylene glycol having a percentage of folded polymeric chains of 40% or higher. The composition is suitable for preparing gas-filled microvesicles.

Abstract: The invention relates to a radiolabelled material comprising a polymer, a radioactive isotope, and an immobilizing agent, wherein the immobilizing agent is capable of immobilizing the radioactive isotope on or in the polymer, and wherein the immobilizing agent is a macromolecule comprising electron donating groups. The invention also relates to a process for making a radiolabelled material, to use of a radiolabelled material for the preparation of medicaments for treating cancer and/or for radiation imaging, and to use of a radiolabelled material in the treatment of cancer. There is further described use of an immobilizing agent to immobilize a radioactive isotope on or in a polymer.

Abstract: Accordingly, the present invention provides a method of treating lung neoplasia in a subject in need of treatment, by subjecting the patient to SIRT.

Abstract: A method for sterilizing biological materials is disclosed. After dehydrating the biological material, the dehydrated biological material is put into a closed container, and 0.01 g/m3 to 1000 g/m3 or an enough dose of ozone gas is introduced into the container for a period of time until the biological material is completely sterilized. Afterward, the ozone gas is removed from the closed container to finish sterilization of the biological material.

Abstract: The invention relates to an electrochemical device which simultaneously carries out the production of an oxidising solution at controlled composition containing hypochlorous acid and the sprinkling thereof in a continuous process, useful for biocide treatments in agricultural fields. The device can be installed on motor vehicles or mobile means in general.

Abstract: Indicator systems and methods associated with high intensity narrow spectrum light are provided. In one example embodiment, a lighting system can include one or more high intensity narrow spectrum (HINS) light sources configured to emit HINS light. The system can further include an indicator circuit configured to provide at least one indicator associated with one or more parameters of the HINS light and/or operational performance of the HINS light sources.

Abstract: A mobile disinfector using UV LEDs can include: a case forming an exterior structure of the disinfector; a cover including two parts coupled to respective sides of the case and including openings formed on the cover; and LED units exposed to outside through the openings formed on the cover. Since the cover is coupled to the case such that an angle between the cover and the case is adjusted, an irradiation angle of light emitted to the outside from the LED units is controlled.

Abstract: There is herein described a plasma treatment system and a method for sterilizing. More particularly, there is described a plasma treatment system for rigid containers and a method of using the plasma treatment system for sterilizing the rigid containers. In some aspects, the plasma treatment system includes a sterilizing apparatus having a receptacle with a flexible passageway or indentation.

Abstract: Sterilization machine for reprocessing an endoscope comprising a fixed part and a mobile part. The fixed part comprises a first frame and a first fluid-dynamic circuit for feeding and/or discharging fluids, and provided with a plurality of first connectors. The mobile part comprises a second frame on which a tank is mounted, a lid to hermetically close the tank and a second fluid-dynamic circuit connectable to the endoscope, able to be selectively coupled removably with the first connectors to achieve the fluidic communication with the first fluid-dynamic circuit. The second frame is provided with rolling means, and the first frame and the second frame comprise guide means and anchoring means to removably anchor the first frame to the second frame.

Abstract: Systems and methods for creating an oxidation reduction potential (ORP) in water for pathogenic control are described. The systems and methods generate an oxidation reduction potential that provides pathogenic control of the solution as well as pathogenic control of the surfaces with which the solution comes in immediate contact. The system supplies the solution to one or more wash-down stations.

Abstract: Systems and methods for creating an oxidation reduction potential (ORP) in water for pathogenic control are described. The systems and methods generate an oxidation reduction potential that provides pathogenic control of the solution as well as pathogenic control of the surfaces with which the solution comes in immediate contact. The system is designed to disinfect and cleanse at least one wall by discharging the water/ozone solution onto the wall at the upper end thereof.

Abstract: The present disclosure is generally related to devices, methods and systems for cleaning, disinfecting and/or sterilizing a medical device, medical hoses and tubes and accessories thereof with ozone gas, in particular the disclosure relates to devices, methods and systems with multiple receptacles for providing closed-loop fluid pathways to distribute ozone gas to inner passageways and the outer compartments of medical devices. The devices in accordance with an embodiment of the disclosure have two or more receptacles for distributing ozone gas, a gas-tight compartment, an ozone operating system, and one or more connector units configured to fluidly migrate ozone in closed-loop treatment systems.

Abstract: The present invention relates to a vacuum exhaust system of a sterilizer, comprising: a sterilization chamber; a first vacuum pump connected to one side of the sterilization chamber; an oil mist trap section for exhausting steam incoming from the sterilization chamber via the first vacuum pump; and a second vacuum pump connected to the first vacuum pump and the oil mist trap section. The vacuum exhaust system of a sterilizer according to the present invention comprises the second vacuum pump connected to the first vacuum pump and the oil mist trap section, wherein by turning the second vacuum pump on to apply a vacuum to the operating oil in the first vacuum pump, thereby providing a certain pressure for evaporating water in liquid state to the first vacuum pump, the present invention can vaporize the water vapor trapped in the operating oil in the first vacuum pump.

Abstract: Scented electronic candle devices are described that facilitate operation and usage of a variety of features such as light or scent or movement of the flame, or a combination thereof. The disclosed features also include multiple settings for the variety of features. For instance, the scent feature can be activated or deactivated by multiple switches, remote, sensors, timers, or similar devices. In addition, the intensity of the scent features can be increased or decreased by increasing or decreasing the amount of heat or air. Similarly the light feature can be activated, deactivated, or set on a timer. Additionally, the scented electronic candle devices can be equipped with rechargeable batteries that can be charged using a wireless charging station or by connecting the scented electronic candle device to an electrical wall outlet.

Abstract: A refill comprises, a container having a body forming a reservoir and an opening in communication with the reservoir, a first composition disposed within the reservoir, a second composition disposed within the reservoir and substantially separated from the first composition, a single wick in contact with the first and second compositions and configured to sequentially emit the first and second compositions. A method of emitting the first and second compositions includes the steps of emitting the first composition until the first composition is substantially depleted and emitting the second composition after the first composition is substantially depleted.

Abstract: The present disclosure provides for and includes improved devices and methods for the production of Purified Hydrogen Peroxide Gas (PHPG) that is substantially non-hydrated and substantially free of ozone.

Abstract: A process of preparing an adhesive haemostatic product is provided. The process comprises: (a) coating a porous solid substrate with a coating liquid that comprises an electrophilically activated polyoxazoline (EL-POX) and a solvent to produce a coated substrate; and (b) removing the solvent from the coated substrate. The EL-POX comprises at least 2 reactive electrophilic groups. The process enables the application of an EL-POX coating that leaves the pore structure of the substrate largely intact so that the ability of the porous substrate to absorb body fluids, such as blood, remains essentially unaffected. The EL-POX coated haemostatic product obtained by the present process has excellent adhesive properties due to the presence of electrophilic reactive groups that are capable of reacting with e.g. amine groups that are naturally present in tissue, under the formation of covalent bonds.

Abstract: Polymeric materials are disclosed herein that include a Polymer A, a Polymer B, and an oxalate ester or reaction product thereof. Polymer A contains electrophilic reactive groups, and Polymer B contains nucleophilic groups. In certain embodiments, the polymeric materials are free-flowing liquids at 100% solids that can be used, for example, as topical skin adhesives.

Abstract: Primarily described are gel-forming systems, consisting of or comprising a composition (A), comprising one or several cationically crosslinkable polymer(s), and a composition (B), comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s) for use in a method for removing urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, from a region of the urinary tract, more particularly a kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, with the following steps: (i) providing the compositions (A) and (B), (ii) introducing the compositions (A) and (B) into a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, under conditions enabling crosslinking of the cationically crosslinkable polymer(s

Abstract: A method for reconstructing a functional tooth by using a carrier loaded with a plurality of mesenchymal stem cells including at least one of a stem cell derived from Apical Papilla (SCAP), Periodontal Ligament Stem Cells (PDLSC), and Dental Pulp Stem Cells (DPSC). The mesenchymal stem cell loaded carrier is planted into a site within a subject's oral cavity to form a bio-root upon which a crown may be affixed, The mesenchymal stem cells will develop new periodontal tissues to stabilize the bio-root. Methods disclosed herein are particularly beneficial for subjects lacking good bone structures for conventional crown treatments.

Abstract: The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. as a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis. In particular, the disclosure involves tissue structure formation around a subcutaneously implanted synthetic rod. In addition, the disclosure involves a method for producing said synthetic rod.

Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. More specifically, a drug-eluting scaffold is implanted in the middle meatus to treat chronic sinusitis for weeks to months.

Abstract: Provided are a tissue structure mimetic used for regenerating a tissue and a method for manufacturing the same, and more particularly, a 3-dimensional tissue structure mimetic which consists of a complex of extracellular matrix protein and bone mineral, wherein the complex is specifically bound to a regeneration-functional peptide to thereby be capable of implementing environment of a tissue requiring restoration, and a method for manufacturing the same. In the tissue structure mimetic according to the present invention, bone mineral components are finely dispersed in the extracellular matrix protein to have excellent mechanical strength of the tissue structure mimetic and conductivity which provides a migration path of cells involved in tissue regeneration. Further, environment of the tissue may be implemented by the peptide contained in the tissue structure mimetic to finally remarkably increase tissue regeneration capacity.

Abstract: A method for retaining demineralized bone matrix particles within a container utilizing a filter device is provided. The method is performed during surgical procedures where bone graft containing demineralized bone matrix particles is used. The filter device is dimensioned for use with a container having a mixture of bone graft material including demineralized bone matrix particles and liquid, whereby the filter device is placed in the container, the liquid is poured off through the pores in the filter device, and the demineralized bone matrix particles are retained with bone graft material in the container.

Abstract: Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of amnion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.

Abstract: Disclosed are composites comprising water-soluble polymeric fibers dispersed in a biodegradable polymer matrix, as well as methods of making and using such composites.

Abstract: A porous matrix suitable for use as a tissue scaffold is described. The matrix may be shaped before insertion into or at the target tissue site, or injected via a minimally invasive method. The matrix may be pre-seeded with cells of the target tissue or may be used to support growth of the local endogenous tissue. The matrix may contain growth factors or other pharmacologically acceptable moieties such as antibiotics.

Abstract: A vascular access device includes an antimicrobial coating that provides kink resistance to a catheter. The antimicrobial coating can extend along a length of the catheter to provide antimicrobial protection when the catheter is inserted into the patient's vasculature. The antimicrobial coating can also increase the effective diameter of the catheter to minimize the likelihood that the catheter will become kinked.

Abstract: Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations of the vasculature with radiopaque hydrogel filaments with delayed controlled rates of expansion. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.

Abstract: The present disclosure provides for co-electrophoretic deposition (co-EPD) of organo-functionalized strontium fluoride nanoparticles (SrF2) with a hydrophobic polymer in the presence of non-aqueous aprotic solvents. The co-EPD procedure can be employed to form a coating or self-supporting film for application to a metal implant.

Abstract: Provided are a stent in which a surface of a stent strut is treated by femtosecond laser radiation and is modified by a natural polymer and a method of preparing the stent. The stent and the preparing method may inhibit restenosis and stimulate reendothelialization.

Abstract: Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.

Abstract: Compositions containing chlorhexidine gluconate solubilized in hydrophobic vehicles are described. Resin systems containing such chlorhexidine gluconate compositions, including adhesives and articles incorporating such resin systems, including medical articles such as drapes are also described.

Abstract: A cassette module (1), in particular an ophthalmological cassette module (1), serves for receiving material and/or liquids aspirated during an operation and for insertion into a container chamber (8) of a suction module (19). The cassette module (1) comprises a container (4) with a container wall (3) that delimits a receiving space (33) for receiving the liquids, wherein the container (4) can be inserted into the container chamber (8), wherein the container (4) has at least one inlet opening (36) extending through the container wall (3), through which inlet opening (36) the material and/or the liquid can be delivered to the receiving space (33) of the container (4), and wherein the container (4) has at least one vacuum opening (25) which extends through the container wall (3) and by way of which the receiving space (33) can be subjected to an underpressure built up in the container chamber (8).

Abstract: A system and method for performing tissue therapy may include applying a reduced pressure to a tissue site, sensing a fluid parameter being applied to the tissue site, generating a fluid sensor signal in response to sensing the fluid parameter, and altering the fluid sensor signal in response to sensing that the fluid parameter changes. A fluid leak location mode may be entered. In response to the fluid leak location mode being entered, a graphical user interface that provides for fluid leak location functionality may be displayed. In one embodiment, the fluid leak location mode may be automatically entered in response to the sensor signal crossing a threshold value. Additionally, an alarm signal may be generated in response to determining that the fluid sensor signal crosses the threshold value.

Abstract: A device for selectively filtering a substance suctioned from a surgical site includes a valve that may be positioned in a bypass mode and a filtration mode. The valve is placed within a body that includes an inlet and an outlet. In the bypass mode, a first inlet of the valve is adapted to be aligned with the body inlet. The first inlet guides the substance through a bypass passageway to the body outlet. In the bypass mode, a bowl and a filter of the body are sectioned off from a flow path of the filtration device such that the bowl and the filter can be removed without interrupting an application of suction to a surgical site by the filtration device. In a filtration mode, a second inlet of the valve is adapted to be aligned with the body inlet to direct the substance into the filter.

Abstract: A system and method for a vacuum wound device. The system includes a wound vacuum device. The vacuum device includes a compressible sponge, vacuum tubing, and a delivery tube sized to house the wound vacuum device. The wound vacuum device is connected to a vacuum pump which creates and delivers the vacuum.

Abstract: A shunt rivet for implantation between a first body space and a second body space in a patient, such as to treat chronic obstructive pulmonary disease.

Abstract: A blood pump has a hollow body in which an impeller with a spiral blading produces an axial propulsion of blood along the impeller, as well as an at least partly actively stabilized magnetic bearing device and a hydrodynamic bearing device for the impeller. The impeller may be set into a rotation about a rotation axis of the impeller with a motor stator located outside the hollow body. The hollow body has an inlet for the flow of blood into the hollow body in an inflow direction which is essentially parallel to the rotation axis, and an outlet for the outflow of the blood out of the hollow body in an outflow direction which is offset to the rotation axis of the impeller to produce a non-zero outflow angle (?) between the inflow direction and the outflow direction. A total artificial heart can be formed from two such blood pumps.