Abstract: Systems and methods for modeling and detecting white blood cell population dynamic for diagnosis and treatment, e.g., of acute coronary syndrome or leukocytosis.

Abstract: A wireline system and method for removing wireline noise from an electromagnetic wireline tool comprising. The system may comprise a wireline measurement tool, which may comprise a wireline measurement tool body, a wireline cable traversing the tool body, and a wireline signal sensor measuring a signal induced by the wireline cable. The system may further comprise an electromagnetic wireline tool, comprising a wireline tool body, the wireline cable traversing the tool body, and a receiver measuring a signal. A method may comprise running the electromagnetic wireline tool into a wellbore on a wireline, recording wireline signals with a wireline signal sensor on a wireline measurement tool, recording signals with a receiver disposed on the electromagnetic wireline tool, and adjusting recorded signals on the receiver by subtracting filtered recorded signals from the wireline signal sensor.

Abstract: A method having: acquiring pressure distribution data at which there are a plurality of measurement points for which forces along three axes have been measured; calculating friction coefficients based on the forces along the three axes at the respective measurement points; generating associated data, linking a contact patch pressure and a maximum friction coefficient that is capable of being exhibited at the contact patch pressure, for a plurality of situations based on a single situation represented by a contact patch pressure and a friction coefficient exhibited at the contact patch pressure at a single measurement point; identifying maximum friction coefficients corresponding to contact patch pressures at respective measurement points based on the associated data; and calculating a margin of the friction coefficient, which is a difference between the maximum friction coefficient and the friction coefficient.

Abstract: A device and method are provided for testing the effectiveness of an adhesive composition to adhere a sheet of material to a substrate. A connector is attached to the sheet and the adhesive is used to adhere the sheet to the substrate and permitted to cure to a selected amount. After (or even before, if desired) the adhesive cures, a load is applied to the connector, having the effect of pulling the sheet away from the substrate. The duration of the pulling and the amount of the load can be varied. If too large a dome is formed under the location of the connector, the adhesive does not pass the test. Optionally, the adhesive formulation is adjusted to make it stronger to resist such doming.

Abstract: The present claimed invention makes it possible to simplify a structure of a multiple-reflection cell and to measure both a measuring objective component having a high concentration and a measuring objective component having a low concentration. The analysis device of this invention is to irradiate a light to a multiple-reflection cell into which a sample is introduced, to detect the light exiting from the multiple-reflection cell and to analyze a measuring objective component contained in the sample, and comprises a first light irradiation part that allows a first light to enter the multiple-reflection cell and a second light irradiation part that allows a second light to enter the multiple-reflection cell. The multiple-reflection cell has a pair of reflecting mirrors that reflect the first light and the second light.

Abstract: A multi-passage photoacoustic device for detecting gas includes a first portion having a stable optical cavity function and having a diameter D and having a concavity with a bend radius R, the diameter D and the bend radius R being such that 0 ? ( 1 - D R ) 2 ? 1 ; a second portion having an acoustic resonator function and having a first end having a first diameter D1 and a second end having a second diameter D2 less than the first diameter D1, the diameter of the second portion decreasing between its first and second ends; an opening for the introduction of a light beam; a gas supply system for introducing a gas to detect; an acoustic detector coupled with the second end of the second portion.

Abstract: A urine screen and urine analysis method for analyzing urine color to determine the hydration level of an individual. The urine screen is nonabsorbent. The urine screen includes a base member, a urinal dish, and a color scale. The urinal dish has a side wall that extends from the front side of the base member. The urinal dish is open at the top portion and is able to receive fluid into the urinal dish through the open top portion. The urinal dish includes a small drain hole. The color scale is applied to the front side of the base member and includes at least a plurality of shades of yellow. Each of the shades of yellow corresponds to a hydration level based on urine color.

Abstract: A plurality of monitoring devices are arranged at different heights and steps, and infrared reflective assemblies of the monitoring device are set at different heights to collect infrared spectral data of chemical constituents of the air mass that are being diffused in airspace of different heights. The pollution factors contained in the air mass and the pollution level of each factor are learned by using IR spectrum for qualitative and quantitative analysis on the pollution factor, therefore realizing continuous monitoring in a certain area. Artificial duty is not required while 24-hour continuous intelligent monitoring can be achieved. Besides, meteorological data are collected in combination with the meteorological data collected by the meteorological information acquisition module at different heights and calculation is made based on the air diffusion model of various pollution factors to finally determine the position of air pollution source.

Abstract: The invention relates to a source (100) comprising a membrane, the membrane comprises: an emissive layer (130) comprising an emissive surface (131). adaptation means (121a, 121b, 121c, 121d), each adaptation means (121a, 121b, 121c, 121d) facing a different section of the emissive section (131), called the emissive section (132a, 132b, 132c, 132d), and with which it forms an emissive assembly (134a, 134b, 134c, 134d) adapted to reduce the spectral extent of infrared radiation emitted by the emissive section, a plurality of means (140a, 140b) of heating the emissive layer (130), the heating means (140a, 140b) being arranged so as to impose different relative temperature variations in different emissive sections (132a, 132b, 132c, 132d).

Abstract: A method includes decomposing a training set to obtain a principal component matrix having a plurality of principal component vectors. The method also includes variably rejecting portions of a sample spectrum vector that do not correspond to a selected one of the plurality of principal component vectors by incrementally providing a coefficient indicative of the weighting of the selected principal component vector for selected sub-regions. A corrected spectrum vector can be obtained by excluding certain sub-regions of the sample spectrum vector and corresponding principal component vector, multiplying the sample spectrum vector with the principal component matrix for non-excluded sub-regions, providing a predicted interference vector, and subtracting the predicted interference vector from the sample spectrum vector.

Abstract: A mass spectrometer using near infrared (NIR) fluorescence can comprise: a plate formed such that a sample, which includes a matrix for ionization and a fluorescent material having an excitation wavelength of an NIR wavelength band, is loaded thereon; a fluorescence detection unit formed so as to acquire a fluorescence image by using the fluorescent material from the sample on the plate; a light emission unit formed so as to emit a laser beam for ionization at the sample on the plate; and an ion detection unit formed so as to detect, by using the laser beam, ions generated from the sample. By using the NIR fluorescence, fluorescence interference due to a matrix used for MALDI imaging can be excluded even after coating the matrix, and since fluorescence interference due to auto-fluorescence inside tissue is low, fluorescence can be measured even for a thick sample.

Abstract: A method and system for detecting moisture in a composite sandwich panel for an aerospace vehicle. A pulse of an electromagnetic radiation beam is beam steered to the composite sandwich panel. The pulse of the electromagnetic radiation beam has a number of wavelengths that is absorbed by water molecules. The timing of the pulse of the electromagnetic radiation beam is synchronized to heat the composite sandwich panel with a time window in an infrared detector system to detect an amount of infrared radiation. The amount of infrared radiation in the composite sandwich panel is detected within the time window for the infrared detector system when the composite sandwich panel is heated by the pulse of the electromagnetic radiation beam, wherein the amount of infrared radiation indicates a level of moisture in the composite sandwich panel.

Abstract: A method and system for an aerospace vehicle. A pulse of electromagnetic radiation is transmitted into the composite sandwich panel such that the composite sandwich panel is heated above an ambient temperature. An amount of infrared radiation generated in the composite sandwich panel is detected in response to transmitting the pulse of electromagnetic radiation into the composite sandwich panel using a time window selected to detect the amount of infrared radiation when the pulse of electromagnetic radiation heats the composite sandwich panel. The amount of infrared radiation detected indicates a level of moisture in the composite sandwich panel.

Abstract: The disclosure features systems and methods for measuring and diagnosing target constituents bound to labeling particles in a sample. The systems include a radiation source, a sample holder, a detector configured to obtain one or more diffraction patterns of the sample each including information corresponding to optical properties of sample constituents, and an electronic processor configured to, for each of the one or more diffraction patterns: (a) analyze the diffraction pattern to obtain amplitude information and phase information corresponding to the sample constituents; (b) identify one or more particle-bound target sample constituents based on at least one of the amplitude information and the phase information; and (c) determine an amount of at least one of the particle-bound target sample constituents in the sample based on at least one of the amplitude information and the phase information.

Abstract: An acoustic scatterometer 502 has an acoustic source 520 operable to project acoustic radiation 526 onto a periodic structure 538 and 540 formed on a substrate 536. An acoustic detector 518 is operable to detect the ?1st acoustic diffraction order 528 diffracted by the periodic structure 538 and 540 while discriminating from specular reflection (0th order 532). Another acoustic detector 522 is operable to detect the +1st acoustic diffraction order 530 diffracted by the periodic structure, again while discriminating from the specular reflection (0th order 532). The acoustic source and acoustic detector may be piezo transducers. The angle of incidence of the projected acoustic radiation 526 and location of the detectors 518 and 522 are arranged with respect to the periodic structure 538 and 540 such that the detection of the ?1st and +1st acoustic diffraction orders 528 and 530 discriminates from the 0th order specular reflection 532.

Abstract: Disclosed herein are methods comprising illuminating a first location of a plasmonic substrate with electromagnetic radiation, wherein the electromagnetic radiation comprises a wavelength that overlaps with at least a portion of the plasmon resonance energy of the plasmonic substrate. The plasmonic substrate can be in thermal contact with a liquid sample comprising a plurality of particles, the liquid sample having a first temperature. The methods can further comprise generating a confinement region at a location in the liquid sample proximate to the first location of the plasmonic substrate, wherein at least a portion of the confinement region has a second temperature that is greater than the first temperature such that the confinement region is bound by a temperature gradient. The methods can further comprise trapping at least a portion of the plurality of particles within the confinement region.

Abstract: [Object] To propose an information processing device, an image acquisition system, an information processing method, an image information acquisition method, and a program which enable a position of a surface of a measurement subject to be more simply specified.

Abstract: A fluorescence observation method includes a fluorescence imaging step of imaging fluorescence from an observation target by an imaging portion. The fluorescence imaging step includes a darkening step of darkening a space between the observation target and an observation window of the imaging portion by pressing a tip end portion of a light shielding member to the observation target or a placement surface of the observation target, in a state where a base end portion of the light shielding member including a tubular main body portion is attached to the imaging portion to surround the observation window, and a focus adjustment step of adjusting a focus position of the imaging portion.

Abstract: A multi-surface image acquisition system includes a multi-surface observation prism which includes one or more prisms and has a light path formed to collect surfaces in respective directions to be observed of a subject having a three-dimensional structure into one direction, in which a light path length is corrected by utilizing a difference in refractive index between glass and air to equalize a working distance of each surface. A light field camera expands a focal-depth adjustment range for two or more images focused on same plane through the prism. A three-dimensional subject can be observed in multiple directions at the same time, including an observation of cells.

Abstract: Provided are methods, devices, assemblies, and systems for dispensing into the wells of a multi-well device and imaging such wells from multiple Z-planes. Multi-Z imaging of the present methods and systems may allow for the detection of wells of a multi-well device that contain a desired number of cells. Also provided are methods, devices, assemblies, and systems for processing cell-containing wells of a multi-well device identified through the use of multi-Z imaging.

Abstract: An optical information detection apparatus includes: a needle-shaped light spot irradiation part that is configured to generate needle-shaped light spot concentrated over a length dimension g greater than a width dimension w along an optical axis, a shifting light spot conversion part that is configured to convert emission light emitted from positions of a detection object into shifting light spot, a shifting light spot reception part that is configured to receive the shifting light spot along a light-receiving plane, and an optical information acquisition part that is configured to acquire optical information from the positions from the shifting light spot.

Abstract: An observation assistance device of the present invention includes: an information storage unit that stores sample state information showing a sample state change, a type of sample, a type of fluorescent substance, and an observation condition in fluorescence observation performed on a predetermined sample, and under a predetermined observation condition; an input unit via which inputs the type of sample to be observed and the type of fluorescent substance to be used; an assistance-display generating unit that reads sample state information and an observation condition of fluorescence observation performed on the same type of sample as the type of sample input, using the same type of fluorescent substance as the type of fluorescent substance, and generates an assistance display showing the sample state information in relation to the two or more parameters included in the observation condition; and a display unit that displays the generated assistance display.

Abstract: A method of making a SERS active substrate and a SERS active substrate. The method comprises depositing a first layer and replicating a plurality of pores of a nanoporous template layer in the first layer so as to define corresponding pores in the first layer. The first layer consists of a metal. Depositing the first layer comprises at least partially coating the sidewalls of the pores of the nanoporous template layer, thereby defining a plurality of out-of-plane SERS active nanofeatures in the first layer.

Abstract: A carrier for single molecule detection is related. The carrier includes a substrate; a middle layer, on the substrate; and a metal layer, on the middle layer; wherein the substrate is a flexible substrate, the middle layer includes a base and a patterned bulge on the base, the patterned bulge includes a plurality of strip-shaped bulges, the metal layer is on the patterned bulge.

Abstract: A molecular detection device is related. The device includes a carrier, a detector and a control computer. The carrier includes a substrate, a middle layer and a metal layer. The middle layer is sandwiched between the substrate and the middle layer. The detector is configured to detect molecules on a surface of the carrier. The control computer is connected to the detector and configured to analyze a detection result. The middle layer includes a base and a patterned bulge on the base, and the patterned bulge includes a plurality of strip-shaped bulges, the metal layer is on the patterned bulge.

Abstract: An optical test system includes a stage region to accommodate an object to be tested, a first incident optical system which changes a first polarization state of a first light beam to a second polarization state and provide the first light beam in the second polarization state to the stage region in a first direction at a first incident angle which is not a right angle, a second incident optical system which changes a third polarization state of a second light beam to a fourth polarization state and inputs the second light beam in the fourth polarization state to the stage region in a second direction at a second incident angle which is not a right angle, and a main optical system to detect a first reflected light beam reflected from the stage region at a first reflection angle different from the first and second incident.

Abstract: A collapsible light tunnel includes pairs of vertical, (optional angled) and overhead light panels collapsibly coupled together and moveable between a stowed position and a deployed position. The light panels include strips of LED lights, light diffusers, and fixtures/brackets for maintaining the panels in the deployed position. The overhead (and angled) light panels are collapsible adjacent the vertical panels in the stowed position.

Abstract: A non-destructive measurement unit of gas concentration in sealed containers and an automatic filling and/or packaging line using such a unit are provided. The flexible containers are at least partially optically transparent, and the measurement unit comprises a light source for emitting a light beam at a wavelength tunable with an absorption wavelength of a gas contained in the sealed flexible container. The light source directs the light beam toward at least one inspection area, and a detector detects at least a portion of the beam after the beam passes through the inspection area and outputs data representative of an absorption spectrum of the gas. Means for generating a head space of predefined width into the sealed flexible container is adapted to advance the sealed flexible container by an advancement path which crosses the inspection zone and to maintain the predefined width of the head space during the advancement.

Abstract: A phase contrast X-ray imaging system for imaging an object including an X-ray source; and an X-ray detector having a 25 micron or less pixel pitch; wherein a distance between the X-ray source and the object is less than or equal to 10 cm.

Abstract: A system for non-destructive testing of an overhead energized electrical component. The system has a base, an X-ray source, an X-ray digital imager, and an imager controller. The system also has a removable electrically conductive flexible shield which is adapted to be operatively coupled to, and to encapsulate, at least the base, the X-ray source, the X-ray digital imager and the imager controller so as to form a shrouded system. In a use position, when the shrouded system is positioned adjacent the energized electrical component so as to non-destructively test the energized electrical component, the shield protects at least the base, the X-ray source, the X-ray digital imager and the imager controller from electric fields around the energized electrical component while allowing signal communication between at least the X-ray source and the energized electrical component.

Abstract: In an embodiment, a method for determining the concentration of an element of a heteroepitaxial layer includes generating a reciprocal space map in Qz and Qx directions in a portion of reciprocal space describing positions of diffracted X-ray peaks of a heteroepitaxial layer and of a substrate on which the heteroepitaxial layer is positioned, determining the position of a diffracted X-ray peak of the substrate in the reciprocal space map in the Qx direction, determining the expected position of the diffracted X-ray peak of the heteroepitaxial layer in the Qx direction based on the determined position of the diffracted X-ray peak of the substrate in the Qx direction, generating a scan of the heteroepitaxial layer in a Qz direction at the expected position in the Qx direction, and determining the concentration of a constituent element of the heteroepitaxial layer based on the scan.

Abstract: A method of inspecting semiconductors and a semiconductor inspection system are disclosed. In an embodiment, the method comprises directing a charged particle beam onto a semiconductor device at an angle in a range between five degrees and eighty-five degrees from a normal to a top surface of the semiconductor; scanning the particle beam across a field of the semiconductor device; adjusting the semiconductor to maintain the particle beam at a defined focus on the semiconductor while scanning the particle beam across the field of the semiconductor device; detecting secondary and backscattered electrons from the semiconductor; and processing the detected secondary and backscattered electrons to inspect for defined conditions of the semiconductor. In an embodiment, the particle beam is maintained at the defined focus on the semiconductor device by controlling the position of the semiconductor device relative to a beam emitter that emits the particle beam.

Abstract: A method of inspecting a sample with a charged particle beam device is described. The method comprises arranging the sample on a stage, determining a first focusing strength of an objective lens adapted to focus a charged particle beam on a first surface region of the sample that is arranged at a first distance from the objective lens in a direction of an optical axis, calculating a difference between the first distance and a predetermined working distance based on the determined first focusing strength, adjusting a distance between the first surface region and the objective lens by the calculated difference, and inspecting the first surface region. According to a further aspect, a charged particle beam device configured to be operated according to the above method is described.

Abstract: The invention relates to a method (100) for determining the depth of a crack in a solid, which includes: a step (105) of determining at least one speed for scanning a surface of the solid comprising the crack by a positioned heat source; for every speed determined: a step (110) of scanning a portion of the surface of the solid, parallel to the general direction of the crack, by the heat source at said speed; and a step (115), synchronous with the scanning step, of detecting at least one value of a physical quantity representing the local heating of the surface of the scanned solid; and a step (120) of determining the depth of the crack as a function of at least one value detected at least at one predetermined scanning speed.

Abstract: There is a need to provide an impedance measuring semiconductor circuit and a blood-sugar level meter capable of improving the accuracy of measuring the impedance of a specimen, reducing an area in an analog front-end LSI chip, and reducing the LSI chip size. According to an embodiment, an impedance measuring semiconductor circuit includes: an operational amplifier; a resistance coupled between a negative input terminal and an output terminal of the operational amplifier; a D/A converter coupled to a positive input terminal; a switch; an A/D converter that is coupled with the output terminal of the operational amplifier and a one-side terminal of a specimen and measures an output voltage from the operational amplifier and a one-side terminal voltage; and a controller that controls an output voltage from the D/A converter based on a one-side terminal voltage measured by the A/D converter.

Abstract: A method of determining if unstable asphaltenes are present in a crude oil sample includes obtaining a crude oil sample and performing a fractional analysis of the crude oil sample. In one embodiment, the method further includes measuring, via a cylindrical capacitor, a dielectric constant of the crude oil sample. Responsive to the measured dielectric constant, presence of unstable asphaltenes within the crude oil sample is determined. Responsive to the determined presence of unstable asphaltenes in an amount above a predetermined value, asphaltene precipitation is mitigated by addition of a chemical additive to the well.

Abstract: A method of fracturing a subterranean formation penetrated by a well comprises: combining an aqueous carrier with a superabsorbent polymer and a borated galactomannan to form a hydraulic fracturing composition; and pumping the hydraulic fracturing composition into the well.

Abstract: A microfluidic chip suitable for detecting a microdroplet includes a first component, a second component, a channel layer, and a semiconductor chip. The first component includes a first substrate, a first electrode layer, and a first dielectric layer, wherein the first electrode layer is located between the first substrate and the first dielectric layer. The second component is disposed opposite to the first component and includes a second substrate, a second electrode layer, and a second dielectric layer. The channel layer is located between the first component and the second component. The semiconductor chip is disposed at one side of the first substrate and is exposed to the channel layer to assist in treating or detecting a sample or microdroplet. The microdroplet in the sample entering the channel layer is reacted with the semiconductor chip, and thus the sample is detected.

Abstract: Embodiments of the present disclosure relate to various methods and example systems for carrying out analog-to-digital conversion of data acquired by arrays of nanogap sensors. The nanogap sensors described herein may operate as molecular sensors to help identify chemical species through electrical measurements using at least a pair of electrodes separated by a nanogap. In general, the methods and systems proposed herein rely on digitizing the signal as the signal is being integrated, and then integrating the digitized results. With such methods, the higher sample rate used in the digitizer reduces the charge per quantization and, therefore, the size of sampling capacitors used. Consequently, sampling capacitors may be made factors of magnitude smaller, requiring less valuable space on a chip compared to sampling capacitors used in conventional nanogap sensor arrays.

Abstract: An analytical device for analysing ions is provided comprising a separator 2 for separating ions according to a physico-chemical property and an interface 3 comprising one or more ion guides. A quadrupole rod set mass filter 4 is arranged downstream of the interface 3. A control system is arranged and adapted: (i) to transmit a first group of ions which emerges from the separator 2 through the interface 3 with a first transit time t1; and (ii) to transmit a second group of ions which subsequently emerges from the separator 2 through the interface 3 with a second different transit time t2.

Abstract: An apparatus includes a first electrode and a second electrode. The second electrode is placed in parallel with the first electrode to provide constant gap distance. The gap between the first electrode and the second electrode is at atmospheric pressure. Ions are introduced into the center of the gap and travel through the apparatus in a direction parallel to the first electrode and the second electrode. The apparatus is configured as a high-field symmetric-waveform apparatus for filtering high mobility ions or for fragmenting ions. The apparatus is also configured for three modes of operation: as a conventional DMS; as a filter high mobility ions; and as fragmentation device. A symmetric electric field is produced in the gap with a maximum density normalized field strength greater than 10 Td to filter high mobility ions and with a maximum density normalized field strength greater than 100 Td to fragment ions.

Abstract: To provide a chemical sensor that enables high detection accuracy. A chemical sensor includes a substrate, two or more magnetoresistance-effect elements disposed side by side in a substrate in-plane direction over the substrate, a first film disposed over a region between the magnetoresistance-effect elements adjacent to each other, and a second film disposed over the magnetoresistance-effect elements, wherein the second film has higher solubility in a specific liquid than the first film.

Abstract: An object is to simultaneously visualize a plurality of junction surfaces of a workpiece. An ultrasound imaging device serving as solution means includes a signal processing unit that causes a probe to irradiate a workpiece with an ultrasound wave having a predetermined frequency, and that performs gate processing on a reflected wave of the ultrasound wave detected by the probe so as to output a displacement of the reflected wave on two junction surfaces of the workpiece, an image generation unit that generates respective images of the two junction surfaces, based on the displacement of the respective reflected waves on the two junction surfaces, and a height adjustment unit that adjusts a height of a focus of the probe. The height adjustment unit adjusts the height of the probe so as to set the focus of the probe between the two junction surfaces.

Abstract: The invention relates to a test kit which is designed for bioanalysis, in particular for an immunoassay. The test kit comprises at least one measuring sensor (M) for the quantitative detection of a substance and at least one reference sensor (R1, R2, R3) which is already supplied with the substance in a defined manner. In the method for analyzing a test kit, the measuring sensor (M) is read and a measurement value for a concentration, a substance quantity, or a mass is obtained, wherein the read value of the at least one measuring sensor (M) is scaled using the read values of the at least one reference sensor (R1, R2, R3), or a measured value which corresponds to the read value is obtained by means of a compensation curve which puts the read values of the reference sensors (R1, R2, R3) into relationship with the defined supply of the substance to the reference sensors (R1, R2, R3).

Abstract: The present disclosure is directed to a method and system for monitoring hydrogen-induced cracking in at least one test specimen. The method includes the steps of: saturating a test solution with a gas comprising H2S and delivering the saturated test solution into a test cell, wherein the test cell comprises at least one specimen port and at least one test specimen. The specimen port is configured to receive the test specimen. The method also includes the step of exposing the at least one test specimen to the saturated test solution, wherein only one surface of each specimen is exposed to the saturated test solution and the step of scanning the test specimen with a ultrasonic transducer at two or more time points, wherein the ultrasonic transducer is operatively connected to the specimen port and configured to rotate completely around the symmetry axis of the test specimen to complete each scan.

Abstract: The present invention refers to a method of purifying a glucagon-like peptide 1 analogs, the method comprising a two dimensional reversed phase high performance liquid chromatography protocol, wherein the first step is carried out at a pH value between 7.0 to 7.8 using a mobile phase comprising a phosphate buffer and acetonitrile, and the second step is carried out at a pH value below 3.0 using a mobile phase comprising trifluoroacetic acid and acetonitrile.

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

Abstract: The present invention relates to methods for determining a slurry concentration for a slurry of a chromatography resin during a column packing. The present invention provides a more accurate and consistent method for determining a slurry concentration for packing a chromatography column. The method of the present invention utilizes an automated pump to provide a controlled flow rate to consolidate a resin sample. Based on the consolidated resin, a slurry concentration can be determined. The determined slurry concentration can be utilized to pack the resin in a chromatography column with highly accurate bed heights.

Abstract: A peak detecting method according to the present invention includes a first peak detecting step (S1) of detecting, with a first detection sensitivity, one or more peaks in object data whose peak is to be detected; and a second peak detecting step (S5) of detecting one or more peaks in the object data with a second detection sensitivity that is different from the first detection sensitivity. With this method, since two kinds of detection are performed at the different detection sensitivities, a shoulder peak (or a non-shoulder peak) candidate can be chosen from peaks that are detected with one of the detection sensitivities but are not detected with the other detection sensitivity, and thus, a shoulder peak can be appropriately detected with ease.

Abstract: When a peak in a chromatogram is automatically detected by an automatic waveform processing unit and a user thereafter performs a manual operation on the peak, a manual waveform processing unit changes peak information on the peak. A time difference calculation unit calculates an elution time difference between peaks of the same component in two pieces of analyzed data. A peak selection unit selects, for the target data, a peak of the same component as the peak in the analyzed data based on analysis dates and times, namely the sequence of generation dates and times of the pieces of chromatogram data. Based on the elution time difference and the analysis dates and times, a peak information reflection unit reflects the change, made in peak information on the peak in the analyzed data, in peak information on the peak selected in the target data.