Abstract: An impedance reflector apparatus, systems, and methods are provided for detecting a marker implanted within tissue that includes a switch for changing a configuration of an antenna of the marker. The apparatus includes a set of transmit electrodes coupled to a signal generator for transmitting a drive current into tissue to generate an electromagnetic field around the marker, a set of receive electrodes configured to detect voltage signals within the tissue corresponding to the electromagnetic field, and a light source for delivering light pulses into the body to open and close the switch to change the configuration of the antenna of the marker. A processor coupled to the receive electrodes processes the detected voltage signals to identify changes in the electromagnetic field that are synchronized with the light pulses to determine whether the marker is operating properly.

Abstract: The present disclosure is directed to measuring impedance across a plurality of electrode pairs. The disclosed systems and methods may simultaneously provide drive signals between electrode pairs and then sense the voltage signals that develop at the electrodes. Digital signal processing may be used to synchronously demodulate the voltage signal at each electrode to determine impedances at the electrodes. Each electrode pair may be driven at a unique frequency to allow for significantly increasing a number of electrode pairs and/or increasing drive current magnitudes. Synchronous demodulation allows the unique frequencies to be detected independent of each other while minimizing crosstalk. Typically, the drive frequencies are made orthogonal by setting the drive frequencies at harmonics of a common base frequency and measuring a response over an integer number of cycles.

Abstract: A device for use in bariatric surgery includes a flexible hollow tube extending from a proximal end to a distal end and defines a channel therebetween. A series of openings is defined in a distal portion of the tube allowing for fixation of tissue using suction. A flexible member has an initial position disposed alongside the tube and is deployable to a subsequent position in which the flexible member engages a greater curvature of a stomach. The flexible member is configured to be deployable to automatically assume a shape of a greater curvature of a stomach. The flexible member includes a bulging region and a tapering region when deployed. The flexible member is releasably attached to the distal end of the tube.

Abstract: Systems and methods described herein use near field communications to locate a radiating transponder, such as a pill swallowed by a patient. The system can be triggered to turn on and transmit a waveform to a set of antennas attached to, coupled with, or near the patient. The magnetic field emitted by the transponder can be measured by the receiving antennas, for example, using principles of mutual inductance. The differential phase and/or time shifts between the antennas can contain sufficient information to find the location of the transponder and optionally its orientation relative to body coordinates. The system can display the location and/or orientation of the transponder. Further, the pill can include a reservoir to deliver a payload at a particular site of the patient's body based at least in part on the determined location.

Abstract: A system and method for collecting operation data associated with a medical apparatus including an internal device implanted in a subject and an external device that is magnetically-coupled to and drives the internal device. The medical apparatus may be monitored to obtain raw data associated with the operation of the medical apparatus and one or more calculations may be performed on the raw data, wherein the raw data and/or calculated values may be associated with voiding frequency and voiding volume of the subject. A report may be generated from the raw data and/or calculated values. In addition, one or more signals may be sent to the external device and/or a docking station, or communicated by other means, to indicate to the subject that the operation of the medical apparatus should be altered.

Abstract: The present invention relates to systems and methods for measuring and monitoring physiological changes in a body. More particularly, the invention relates to systems and methods for measuring and monitoring the environment in the vicinity of the lung.

Abstract: An article of footwear includes an upper member and a sole structure, with a sensor system connected to the sole structure. The sensor system includes a plurality of sensors that are configured for detecting forces exerted by a user's foot on the sensor. Each sensor includes two electrodes that are in communication with a force sensitive resistive material. The electrodes and the force sensitive resistive material may have multi-lobed shapes. Additionally, the sensor system may be provided on an insert that may form a sole member of the article of footwear. The insert may have slits therethrough, and may have a defined peripheral shape.

Abstract: The inventive concept relates to a skinfold caliper, wherein the skinfold caliper includes a first holder and a second holder respectively having tips approaching or moving away to or from a to-be-measured portion of a to-be-measured object, wherein the first holder and the second holder pivot relative to each other about a pivot axis, a scale unit provided in the first holder, wherein the scale unit has a plurality of angular scales formed along a rotation path of the second holder, a probe unit disposed in the second holder so as to electrically connect to the scale unit, wherein the probe unit senses a relative rotation angle of the second holder relative to the first holder, a pressure measuring sensor provided at the tip of one of the first holder and the second holder, wherein the pressure measuring sensor measures a pressure applied to the to-be-measured portion of the to-be-measured object, and a controller configured for, when the pressure measured by the pressure measuring sensor reaches a predeterm

Abstract: A dual lumen catheter with a measuring scale is disclosed. The catheter has a pair of lumens, one of which is adapted to receive a measuring scale for measuring the length of a lesion within the body. A view port is provided to allow the user to view the measuring scale and determine the length of the lesion.

Abstract: A gait analysis and training system is provided, as well as methods of training, e.g., retraining gait in a patient. The system provides real-time external feedback to a patient is portable so that use is not limited to a clinic.

Abstract: A pulse signal generator circuit generates first and second pulse signals for electrodes placed on the chest of a subject with phases that differ by 180°. A rectifier circuit receives a potential difference signal, which reflects an impedance between the electrodes that changes according to respiratory motion and in which timing of changes caused by changes in the first pulse signal or the second pulse signal is delayed from the timing of the changes in the first pulse signal and the second pulse signal, and outputs a rectified signal produced by rectifying the potential difference signal. A control signal generator circuit causes the rectifier circuit to invert the potential difference signal, which becomes a negative voltage value from the certain timing, to a positive voltage value from the certain timing. An AD converter circuit outputs a digital value based on the magnitude of the rectified signal.

Abstract: Systems, devices, and methods for detecting movement of a user, comprising a portable device, database, and controller, portable device including a sensor assembly and processor, the sensor assembly having a sensor configurable to perform a first measurement, the processor configurable to compare the first measurement to a threshold value, and also configurable to transmit a code when the processor determines, based on the compare, that the first measurement is greater than or equal to the threshold value, the controller being configurable to receive a communication signal having the code and the controller also configurable to obtain, from the received communication signal, the code, and further the controller also configurable to display, on a graphical display, a notification message which includes at least an identification of the portable device user.

Abstract: A sensor pad for monitoring user posture. The sensor pad includes a sensor array having first layer electrodes disposed on a first substrate that faces a second substrate, second layer electrodes disposed on a second substrate that faces the first substrate, a spacer layer disposed between the first substrate and the second substrate and having holes each corresponding to an overlapping region of the first layer electrodes and the second layer electrodes, where the first layer electrodes are configured to contact the second layer electrodes through at least one of the holes via a corresponding overlapping region when an external force is applied on the sensor pad by a user, a sensing circuit configured to generate an output signal in response to the external force, and a sensor correction circuit configured to prevent the sensing circuit from generating a false positive signal in the output signal.

Abstract: Provided herein are systems and devices capable of detecting an event, such as the fall of a human. The devices may include a motion sensor, a heat sensor, and a vibration sensor. The devices and systems also may include an alarm and/or communication device configured to function when the event occurs.

Abstract: This disclosure generally relates to a system for communicating data generated by a wearable device to one or more server devices for analysis. The one or more server devices may transmit activity level data, or a graphical representation thereof, for a wearer of a wearable device to a device associated with a healthcare provider. The activity level data may include one or more of an active minutes element, a television time element, a word count element, a sleep duration element and a reading duration and score element.

Abstract: Pacer activity data of a user may be managed. For example, historical activity data of a user corresponding to a particular time of a day prior to a current day may be received. Additionally, a user interface configured to display an activity goal of the user may be generated and the user interface may be provided for presentation. In some aspects, the user interface may be configured to display a first indicator that identifies cumulative progress towards the activity goal and a second indicator that identifies predicted cumulative progress towards the activity goal. The cumulative progress may be calculated based on monitored activity from a start of the current day to the particular time of the current day and the predicted cumulative progress may be calculated based on the received historical activity data corresponding to the particular time of the day prior to the current day.

Abstract: An alignment guide for determining a human or animal body part range of motion around a joint is disclosed. The alignment guide is adapted to be placed against the body part and to receive a sensor unit. By using the sensor unit, the range of motion of a human or an animal joint in a main plane of rotation can be estimated based on a relative angle between an orientation of the sensor unit in a first measurement position and an orientation of the sensor unit in a second measurement position. A system, as well as a method using the alignment guide and sensor unit is also disclosed.

Abstract: Systems, methods, and software products determine an overall motion, flexibility and/or strength envelope for an individual. Force, movement and position data of the individual is captured and processed to generate an overall motion, flexibility and/or strength envelope for the individual that defines overall motion, flexibility and/or strength of the individual. The system includes a flexibility server with memory and a processor that are adapted to receive force, movement and position data of the individual. A motion, flexibility and/or strength analyzer of the system, implemented as machine readable instructions stored in the memory and executed by the digital processor, is capable of processing the force, movement and position data to generate an overall motion, flexibility and/or strength envelope for the individual that defines the overall motion, flexibility and/or strength of the individual.

Abstract: A sensing system includes a first radar sensing assembly and an analysis system. The first radar sensing assembly measures plural distances to a first target location at different times using radar. The analysis system receives the plural distances from the first radar sensing assembly and quantifies movements of a target object at the first target location at the different times by calculating differences in the plural distances measured by the first radar sensing assembly. The analysis system generates one or more first quantified activity level values indicative of the movements of the target object at the first target location using the differences in the plural distances that are calculated.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: The disclosed invention addresses an unmet need of biofluid analysis by utilizing the presence of certain nucleotides, e.g., microDNA, eccDNA, DNA fragments, microRNA, RNA fragments, and peptides, in a sample biofluid, such as eccrine sweat, apocrine sweat, blood, serum, saliva or tears, to perform a number of physiological sensing functions. Specifically, the present disclosure provides: (1) a device and method of determining whether a biofluid sensing device is being worn by a specific individual based on a measurement of nucleotides in a biofluid; (2) a device and method of recognizing at least one physiological disease or condition based on nucleotide concentrations, ratios, or trends in a biofluid.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: A method and system are provided for measuring post-translational modification of proteins in a subject. The method comprises recording of infrared radiation within a predetermined wavenumber range and attenuated by an integument of the subject, such that the integument is still attached to the subject. The method further comprises the step of comparing the attenuation of infrared radiation to a predetermined value for deriving information regarding post-translational modification of proteins in the integument.

Abstract: Disclosed is a method for initializing an analyte measurement system (1, 2, 3), the analyte measurement system (1, 2, 3) being designed for continuous in-vivo measurement of a body fluid analyte concentration.

Abstract: A apparatus for obtaining an individualized unit spectrum includes: a spectrum obtainer configured to obtain a first biological spectrum from a subject at a first measurement time, and obtain a second biological spectrum from the subject at a second measurement time; and a processor configured to extract the individualized unit spectrum from the first biological spectrum and the second biological spectrum, based on a predetermined unit spectrum of a target component.

Abstract: A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values.

Abstract: Embodiments that compensate for changes to sensor response characteristics (e.g., sensitivity) due to time durations are disclosed. The time durations can be the amount of time the sensor is in a post-manufacture packaged state prior to use, or the amount of time the sensor is in use. Sensor response changes due to other variables can also be compensated for.

Abstract: A sensor port is adapted to connect to either a sensor or a data source. A reader is configured to identify which of the sensor and the data source is connected to the sensor port. A data path is configured to communicate an analog signal associated with the sensor and digital data associated with the data source to a signal processor according to the identification made by the reader.

Abstract: A non-invasive, optical-based physiological monitoring system is disclosed. One embodiment includes an emitter configured to emit light. A diffuser is configured to receive and spread the emitted light, and to emit the spread light at a tissue measurement site. The system further includes a concentrator configured to receive the spread light after it has been attenuated by or reflected from the tissue measurement site. The concentrator is also configured to collect and concentrate the received light and to emit the concentrated light to a detector. The detector is configured to detect the concentrated light and to transmit a signal representative of the detected light. A processor is configured to receive the transmitted signal and to determine a physiological parameter, such as, for example, arterial oxygen saturation, in the tissue measurement site.

Abstract: An embodiment of the present disclosure seeks to smooth a perfusion index measurement through use of a baseline perfusion index measurement and/or through the use of multiple PI calculations. The combination of the baseline perfusion index measurement reduces an error between a calculated measurement of PI and actual conditions.

Abstract: Disclosed herein is a system and method for delivering a digital therapeutic, specific to a user emotional or mental state (EMS). This entails recognizing at least one EMS selected by the user from a plurality of EMS, said selected EMS indicating at least one of a feeling, sensation, type of discomfort, mood, mental state, emotional condition, or physical status of the user. Pushing at least a primary-level message personalized to the user based on at least one stored message coupled to the selected EMS; wherein the at least primary-level messages contain at least one of a text, image, sound, video, art asset, suggested action or recommended behavior. The actions suggested or behaviors recommended are supported by at least one independent source of peer-reviewed research, as verified by a credentialed EMS expert.

Abstract: An automated system may estimate a patient's level of depression throughout a monitoring period. The system may do so without ever receiving any self-reports from the patient, such as patient answers to a survey regarding the patient's affect. The system may predict the patient's depression level based on passive sensor data regarding the patient during the monitoring period. The passive sensor data may include physiological measurements, such as electrodermal activity measurements and accelerometer measurements. The passive data may also comprise data regarding the patient's smartphone and texting usage. The system's predictions may also be based on a single depression rating for the patient by a clinician, without any further assessments by the clinician.

Abstract: Methods, devices and systems are provided for detecting drowsiness or the alertness level of a driver of vehicle. A driver's heart rate variability level is determined based on signals received from one or more sensors placed in the vehicle, such as biometric sensors located in a seat assembly. In response to a low heartbeat variability indicating a drowsy or non-alert driver, one or more output signals may be generated to warn or notify the driver.

Abstract: Disclosed herein is a rodent and human behavioral test for evaluating visual dysfunctions associated with the retinal changes in Alzheimer disease progression. In one example, the inventors developed a maze that tests rodent's ability to identify (1) specific contrasts, (2) specific colors, (3) certain items in the visual field, and (4) other ‘non-typical’ peripheral and night vision functions associated with AD. For instance, the inventors developed a maze the tests the rodents ability to avoid certain colors or contrasts gradients. The maze may include certain rooms with specific visual markers (e.g., colors, contrasts, objects or other visual features) that also contain shock plates.

Abstract: A non-invasive method of detecting anomalous tissue, such as cancerous or injured tissue, in a patient. At least two hemoglobin signal components of hemoglobin levels in at least one segment of tissue of the patient are non-invasively measured over time. Time varying changes of at least a first of the hemoglobin signal components are measured with respect to at least time varying changes of a second of the hemoglobin signal components. A co-varying coordinate system of the time varying changes is generated. Any anomalous tissue in the measured segment of tissue is detected from a signature of the measured segment of tissue in the co-varying coordinate system which differs from a signature of non-anomalous tissue in the co-varying coordinate system. Preferably, five hemoglobin signal components are measured: oxyHb, deoxyHb, total Hb (totalHb=oxyHb+deoxy Hb), Hb oxygen saturation (HbO2Sat=(oxyHb/totalHb)*100), and tissue-hemoglobin oxygen exchange HbO2Exc (deoxyHb?oxyHb).

Abstract: An evaluation method of evaluating a color irregularity site (a blemish) includes a color irregularity site detection step (step S102) of detecting a plurality of color irregularity sites respectively from a first skin image and a second skin image different from the first skin image, a gravity center position calculation step (step S108) of calculating gravity center positional coordinates of the color irregularity sites respectively for the first skin image and the second skin image, and a matching process step (step S110) of matching the plurality of color irregularity sites included in the first skin image with the plurality of color irregularity sites included in the second skin image based on the calculated gravity center positional coordinates of the color irregularity sites.

Abstract: A scoliosis diagnosis assistance device includes: a first shape information acquisition module configured to acquire back shape information representing the three-dimensional shape of a back of a subject; a second shape information acquisition module configured to acquire minor-symmetry information representing a three-dimensional shape having a minor-symmetry relationship with the three-dimensional shape of the back of the subject with respect to a sagittal plane of the three-dimensional shape; a deviation distribution acquisition module configured to acquire a distribution of deviation between the three-dimensional shape represented by the back shape information and the three-dimensional shape represented by the mirror-symmetry information; and an output controller configured to cause a display to display the distribution of deviation, for example.

Abstract: There is provided a method for enhancing heart rate variability of an infant or an animal of a low age or a low age in month. An assist method for assisting to enhance a function of an automatic nervous system of a dependent or an animal cared by a user, comprises, by a computer: a step of monitoring a first index configured to indicate a function of an automatic nervous system of the user; a step of monitoring a second index configured to indicate the function of the automatic nervous system of the dependent or the animal; and a step of providing training contents to the user, wherein the training contents are configured to enhance the function of the automatic nervous system of the user determined based on at least the second index.

Abstract: A wearable device is described. The wearable device comprises: a device body configured to be secured in contact with a subject; a first sensor borne by the device body that is activatable to measure a heart rate of the subject; and control logic configured to activate the first sensor during a monitoring period during which the subject is determined to be in a sleep period.

Abstract: An automated method and system for diagnosing sleep disorders and predicting treatment effectiveness using data collected on the user using an automated application including questionnaire, facial recognition technology, and historical user and patient data. The data can be used by a diagnostic and treatment prediction algorithm to diagnose sleep disorders, for example sleep apnea, and predict treatment effectiveness. The system is an automated, self-learning algorithm capable of assessing the risk for sleep disorders and predicting treatment effectiveness.

Abstract: A therapeutic support apparatus includes a user support surface extending along a longitudinal axis. The user support surface has a head section and a torso section. Each of the head section and the torso section are operable to angle relative to the longitudinal axis. An elevation unit is operable to position at least one of the head section and torso section at angles relative to the longitudinal axis. A monitor acquires data related to a user while sleeping on the user support surface. An alarm is operable to activate based on the data acquired by the monitor.

Abstract: The invention provides methods of measuring the progression and effectiveness of a course of treatment of bladder cancer in a subject diagnosed with a bladder cancer, by applying a physiologically acceptable dye to the tumor and measuring the degree of progression and effectiveness of the course of treatment of the bladder cancer.

Abstract: A measuring apparatus includes: a measurement unit configured to measure a concentration value of a specified substance contained in a sample; an acquiring unit configured to acquire information about a user's activity status; a calculation unit configured to calculate a concentration value of the specified substance within a second period ranging from present time to second predetermined time after the present time, based on a concentration value of the specified substance within a first period ranging from first predetermined time before the present time to the present time and the information about the user's activity status within the first period; and an informing unit configured to inform a user of the information about the concentration value of the specified substance when the concentration value of the specified substance within the second period does not fall within a range of a predetermined concentration value.

Abstract: An electronic device comprises an enclosure configured for insertion into the ear canal and comprising a distal end configured to extend at least beyond a first bend of the ear canal. A distal temperature sensor is situated at a location of the enclosure that faces a tragus-side of the ear canal between the first and second bends when the enclosure is fully inserted into the ear canal. A proximal temperature sensor is situated on the enclosure at a location spaced apart from a surface of the ear canal and proximal of the distal temperature sensor in an outer ear direction when the enclosure is fully inserted into the ear canal. A processor, coupled to the distal and proximal temperature sensors and to memory, is configured to calculate an absolute core body temperature using a heat balance equation stored in the memory and the first and second temperature signals.

Abstract: A wearable device measures, tracks, and monitors a wearer's physical physiological conditions during a rehabilitation period. Metrics such as temperature, patellar shifting, limb circumference, and acceleration may be collected. Changes in monitored conditions may be assessed for detecting medical abnormalities which require specialized attention, including for example embolisms or infections. A networked communication system and various user interfaces may be used for medical support personnel and patients alike to stay updated with the patient's rehabilitation progress and to make adjustments in a patient's individual rehabilitation program.

Abstract: Apparatus, systems, and methods of manufacture of sensors facilitating monitoring of living entities. In one example, a system comprises a flexible substrate comprising an adhesive adapted to cause the flexible substrate to adhere to a defined surface. A silicon substrate or film can be disposed on the flexible substrate, wherein the silicon substrate or film is formed to include one or more nanogratings adapted to receive and reflect light based on strain on the defined surface.

Abstract: A system for detecting bioelectrical signals of a user comprising: a set of sensors configured to detect bioelectrical signals from the user, each sensor in the set of sensors configured to provide non-polarizable contact at the body of the user; an electronics subsystem comprising a power module configured to distribute power to the system and a signal processing module configured to receive signals from the set of sensors; a set of sensor interfaces coupling the set of sensors to the electronics subsystem and configured to facilitate noise isolation within the system; and a housing coupled to the electronics subsystem, wherein the housing facilitates coupling of the system to a head region of the user.

Abstract: A device (10, 10?, 10?) includes a light source (12) and a light detector (14) spaced from, and in communication with, the light source (12). An electronic processor (18) is programmed to compute pulse oximetry data from output of the light detector (14). A clamping member (26) is included, on or in which the light source (12) and the light detector (14) are disposed. The clamping member (26) is configured for attachment to a human body part with the body part disposed between the light source (12) and the light detector (14) such that light from the light source (12) passes through the body part to reach the light detector (14). The clamping member (26) is configured to attach to the body part by transitioning from a first stable state to a second stable state via a compression force applied to the clamping member (26).

Abstract: A system and method for processing photoplethysmography (PPG) signals in a vehicle. The system and method include determining a plurality of consistent PPG waveform signals based on a plurality of PPG waveform signals and electronically aggregating the plurality of consistent PPG waveform signals into a PPG measurement signal. The system and method also include determining a plurality of noise waveform signals based on a plurality of pressure measurement signals and electronically aggregating the plurality of noise waveform signals into a motion artifacts measurement signal. The system and method further include processing a refined PPG signal to suppress motion artifacts from the PPG measurement signal by filtering a segment of the PPG measurement signal that is attributed to the motion artifacts represented within the motion artifacts measurement signal.

Abstract: Various embodiments provide a mobile communication device to sense and collect a user's diagnostic information. A deployable platform mounted on the mobile communication device, receives touch input from a user's finger. At least one sensor mounted on the deployable platform is used to sense one or more properties associated with the touch input. Diagnostic information associated with the one or more touch input properties is collected and a notification describing the diagnostic information is provided using the mobile communication device.