Patents Issued in May 28, 2019
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Patent number: 10300152Abstract: Disclosed are methods, systems, and devices for implementing nanoparticles to encapsulate biomolecules such as enzymes. In one aspect, a nanoparticle device includes a shell structure including an internal layer structured to enclose a hollow interior region and include one or more holes penetrating through the internal layer, and an external layer formed of a porous material around the internal layer; and an enzyme contained within the interior region of the shell structure, the enzyme having entered the shell structure through the one or more holes and incapable of passing through the external layer, in which the pores are of a size that prevents the enzyme to pass through the pores while permitting substances smaller than the pore size to pass through the pores.Type: GrantFiled: September 17, 2014Date of Patent: May 28, 2019Assignees: The Regents of the University of California, Devacell, Inc.Inventors: Inanc Ortac, Sadik C. Esener, Ibrahim Gokce Yayla, Bradley Messmer
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Patent number: 10300153Abstract: Disclosed are methods, compositions of matter, and protocols useful for the detection of altered cells in a patient. Immune cells capable of clonal expansion are engineered to produce a soluble signal upon activation and/or clonal expansion. The cells may possess a suicide gene, inducible upon administration pharmacological or light/radiation activatable, so as to eliminate the cells from body when desired. In another embodiment, immune cells produce a localized marker, the marker being visible with imaging technology. In other embodiments cells capable of non-clonal expansion are utilized. The disclosure provides means of utilizing the immunosurveillance properties of immune cells to diagnose and localize diseases associated with alteration of host cells.Type: GrantFiled: November 30, 2016Date of Patent: May 28, 2019Assignee: Asthra, LLCInventors: Thomas Ichim, Santosh Kesari
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Patent number: 10300154Abstract: The invention provides cardiovascular imaging agents comprising an anticoagulant (e.g., dabigatran derivatives) with a label (e.g., radiolabeled, fluorinated or radiofluorinated). Methods for using the cardiovascular imaging agents and kits containing the cardiovascular imaging agents or components suitable for production of the cardiovascular imaging agents are also provided.Type: GrantFiled: September 17, 2015Date of Patent: May 28, 2019Inventor: David R Elmaleh
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Patent number: 10300155Abstract: The present invention generally relates to various compounds that are useful as ?-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of synucleinopathies, including Parkinson's disease (PD).Type: GrantFiled: December 29, 2016Date of Patent: May 28, 2019Assignee: Washington UniversityInventors: Zhude Tu, Junfeng Li, Xuyi Yue, Paul Kotzbauer
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Patent number: 10300156Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.Type: GrantFiled: December 18, 2014Date of Patent: May 28, 2019Assignee: GE Healthcare LimitedInventors: Torgrim Engell, Gareth Simon Getvoldsen, Andreas Richard Meijer, Imtiaz Ahmed Khan, Robert James Nairne, Graeme McRobbie
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Patent number: 10300157Abstract: Described is a retail store fixture that includes an electric charge circuit. The electric charge circuit generates a positive electric charge, or voltage, in response to the motion of a moveable portion of the retail store fixture. The retail store fixture can be a shopping cart or other fixture with a moveable portion. The positive electric charge is deposited on a part of the retail store fixture that it is desired to sterilize. The positive electric charge repels bacteria, sterilizing the portion of the retail store fixture that receives the positive charge. A shopping cart, for example, equipped with the electric charge circuit can be sterilized without requiring chemicals or power to be supplied to the cart. Rotation of the shopping cart wheels can be used to generate the voltage. The voltage can be used to sterilize a shopping cart handle, and/or other parts of the shopping cart.Type: GrantFiled: December 16, 2016Date of Patent: May 28, 2019Assignee: WALMART APOLLO, LLCInventors: Matthew Allen Jones, Nicholaus Adam Jones, Robert James Taylor
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Patent number: 10300158Abstract: A code reader may include a housing configured to be adjustably oriented. The housing may include at least one orientation corresponding with a cleaning function. A scanner may be disposed within the housing, and be configured to scan a machine-readable indicia in a target area. An illumination source may be configured to emit an anti-microbial illumination. A processing unit may be in communication with the scanner and illumination source, and be configured to select the cleaning function to cause the illumination source to emit the anti-microbial illumination toward the target area to disinfect surfaces in the target area.Type: GrantFiled: December 22, 2017Date of Patent: May 28, 2019Assignee: Datalogic USA Inc.Inventors: Wesley W. Hardin, Matt Monte, Ryan Thompson
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Patent number: 10300159Abstract: A method for deactivating preferably odor-relevant molecules that is distinguished by the following steps is proposed: generating a plasma; deactivating preferably odor-relevant molecules by the effect of hot electrons of the plasma on the molecules to be deactivated.Type: GrantFiled: May 4, 2012Date of Patent: May 28, 2019Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Gregor Morfill, Tetsuji Shimizu, Julia Zimmermann, Yangfang Li, Bernd Steffes
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Patent number: 10300160Abstract: A plasma liquid generating device includes a tube, a plasma generating module, a flow limiting unit, and a position limiting member. The tube has at least an air inlet and a flow channel outlet. The plasma generating module is disposed adjacent to the air inlet and configured to generate plasma. The flow limiting unit is detachably disposed in the tube, and a distance between the flow limiting unit and the flow channel outlet is greater than a distance between the air inlet and the flow channel outlet. The position limiting member is detachably disposed at the flow channel outlet to limit the position of the flow limiting unit.Type: GrantFiled: June 6, 2017Date of Patent: May 28, 2019Assignee: AMSALP BIOMEDICAL CO., LTDInventors: Jen-Chieh Lu, Yin-Lin Lu
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Patent number: 10300161Abstract: An ice maker includes an ice making unit comprising an evaporator connected to a refrigeration system, an ice holding bin, a sump, a pump, a drain valve, an ozonated water source, and a controller. The controller activates the ozonated water source supplying a first volume of ozonated water to the sump, thereafter activates the pump to circulate the first volume of ozonated water from the sump to the ice making unit, once a predetermined sterilization time has been reached, the controller turns off the pump and drains the first volume of ozonated water from the sump. The controller initiates an ice making mode, and activates the ozonated water source to supply a second volume of ozonated water to the sump, thereafter activates the pump to circulate the second volume of ozonated water from the sump to the ice making unit forming ozonated ice on the evaporator, and initiates an ice harvest mode to remove the ozonated ice from the evaporator and delivers it to the ice holding bin.Type: GrantFiled: June 17, 2016Date of Patent: May 28, 2019Assignee: MANITOWOC FOODSERVICE COMPANIES, LLCInventor: Daryl Gregory Erbs
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Patent number: 10300162Abstract: A disinfectant wipe dispenser is provided comprising a container having first and second compartments, the first compartment being dimensioned to store a supply of wipes in use; and, separated by a baffle including one or more channels communicating between the compartments. The first compartment has an outlet through which wipes may be successively drawn; and, the second compartment is dimensioned to receive one or more portions of a disinfectant composition comprising a peroxy activator, a peroxy compound and optional further excipients, selected so that addition of the dosage form to a predetermined quantity of water produces a disinfectant solution containing peracetic acid at a concentration of at least about 1000 ppm. The channels communicate between the compartments and allow flow of water and aqueous disinfectant between the compartments, and have a maximum dimension configured to prevent movement of particles of disinfectant sediment from the second compartment to the first compartment.Type: GrantFiled: October 6, 2015Date of Patent: May 28, 2019Assignee: PERACIDE (UK) LIMITEDInventor: Michael Joseph
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Patent number: 10300163Abstract: A moisture absorbent and decontaminant is provided. The moisture absorbent and decontaminant includes a receptacle. The receptacle is formed of a permeable material having a plurality of pores. The present invention includes at least first pellets, second pellets and third pellets. The pellets are enclosed within the receptacle. The pellets include a diameter larger than the diameter of the pores and thereby cannot escape the receptacle. The first pellets include an antimicrobial. The second pellets include an antifungal. The third pellets include a moisture absorber.Type: GrantFiled: January 23, 2017Date of Patent: May 28, 2019Inventor: Peter Andrew Bogle
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Patent number: 10300164Abstract: Disposable absorbent articles assembled from a collection of components using an adhesive comprising an amorphous polyolefin composition and a heterophase polyolefin composition comprising amorphous character and crystalline blocks.Type: GrantFiled: March 8, 2018Date of Patent: May 28, 2019Assignee: The Procter & Gamble CompanyInventors: William L. Bunnelle, Robert Haines Turner
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Patent number: 10300165Abstract: Novel semi-crystalline, p-dioxanone-rich ABA triblock copolymers of p-dioxanone and epsilon-caprolactone, where “B” block is a random copolymer of p-dioxanone and epsilon-caprolactone, and absorbable devices for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices.Type: GrantFiled: January 20, 2016Date of Patent: May 28, 2019Assignee: Ethicon, Inc.Inventors: Sasa Andjelic, Kenneth Keilman
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Patent number: 10300166Abstract: The present invention relates to a fibrous haemostat composition that is able to safely gradually and fully degrade in a human or animal body within about 30 days and so can be utilised by physicians to stem a flow of blood and promote healing both after as well as during surgical procedures.Type: GrantFiled: April 4, 2017Date of Patent: May 28, 2019Assignee: MEDTRADE PRODUCTS LIMITEDInventors: Craig Hardy, Andrew Hoggarth, June Gladman
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Patent number: 10300167Abstract: The present invention provides a functionalized composition and resulting functionalized body or prosthesis for in vitro and in vivo use comprising at least one calcium phosphate containing phase that is functionalized with a linker group comprising at least one of an organic acid molecule, a phosphonic acid, an amine, N,N-dicyclohexylcarbodiimide, and 3-maleimidopropionic acid N-hydroxysuccinimide ester, and combinations thereof, and one or more of a chemical and/or a biologically active moieties, wherein the linker group provides for a reactive location for the attachment of the chemical or biologically active moiety, or both, to the calcium phosphate containing phase, and optionally including an unmodified and/or modified calcium aluminate containing phase. Methods of manufacturing a functionalized artificial prosthesis and methods of repairing a bone, vertebrae, or tissue structures are provided.Type: GrantFiled: July 28, 2011Date of Patent: May 28, 2019Assignees: CAberTech, Inc., Duquesne University of the Holy SpiritInventors: Kenneth A. McGowan, Ellen S. Gawalt, Rachelle Palchesko
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Patent number: 10300168Abstract: The present invention relates to polysaccharide soft tissue fillers comprising heparosan and processes for their preparation. The polysaccharide soft tissue fillers of the present invention are advantageously used in therapeutic or cosmetic applications such as for the filling of wrinkles.Type: GrantFiled: March 31, 2015Date of Patent: May 28, 2019Assignee: MERZ PHARMA GMBH & CO. KGAAInventors: Alexander Linko, Andreas Krause, Franck Villain
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Patent number: 10300169Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a silk fibroin component.Type: GrantFiled: August 24, 2017Date of Patent: May 28, 2019Assignee: Allergan, Inc.Inventors: Xiaojie Yu, Darin J. Messina, Elizabeta Pavlovic, Cunqi Cui, Kate M. Smither
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Patent number: 10300170Abstract: Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.Type: GrantFiled: February 26, 2018Date of Patent: May 28, 2019Assignee: LifeNet HealthInventors: Leila Masinaei, Lloyd Wolfinbarger, Jr.
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Patent number: 10300171Abstract: A resorbable crosslinked form stable membrane containing a composite layer of collagen material and inorganic ceramic particles containing 1.5 to 3.5 weight parts of inorganic ceramic for 1 weight part of collagen material, sandwiched between two layers of elastic pretensed collagen material, wherein the elastic pretensed collagen material is collagen material that has been stretched such as to be in the linear/elastic region of the stress-strain curve, the collagen material comprising 50-100% (w/w) collagen and 0-50% (w/w) elastin.Type: GrantFiled: May 10, 2018Date of Patent: May 28, 2019Assignee: Geistlich Pharma AGInventors: Niklaus Stiefel, Sergej Stenzel, Raphael Kaufmann
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Patent number: 10300172Abstract: Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.Type: GrantFiled: October 31, 2016Date of Patent: May 28, 2019Assignee: Bioventus, LLC.Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher Todd Brown
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Patent number: 10300173Abstract: The invention relates to compounds, compositions and methods for biofilm disruption and prevention. In particular, the invention relates to pharmaceutical compositions for the disruption of biofilm and prevention of biofilm in patients. The invention also relates to anti-biofouling compositions for the disruption of biofilm and prevention of biofilm on surfaces. The invention also relates to the removal of biological material from surfaces. The compositions of the invention include microbial deoxyribonucleases.Type: GrantFiled: May 4, 2017Date of Patent: May 28, 2019Assignee: University of Newcastle Upon TyneInventors: James Grant Burgess, Michael John Hall, Reindert Nijland
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Patent number: 10300174Abstract: There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 ?g/cm2.Type: GrantFiled: December 19, 2017Date of Patent: May 28, 2019Assignee: Bactiguard ABInventors: Mattias Ohrlander, Billy Södervall
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Patent number: 10300175Abstract: A plasma-activated coating (PAC) process covalently binds enzymes in their bioactive state, has low thrombogenicity and can be robustly applied to medical devices, resisting delamination when deployed in vivo. Applying this process to attachment of proteins such as enzymes that inhibit thrombosis and anticoagulants such as heparin or heparin fragments, one can produce medical devices and other materials for use in vascular applications having a number of benefits including covalent attachment, not requiring intermediate linkers or chemistry; substrate independent—works on polymers, metals, ceramics, 3D shapes like stents, valves, etc.; bioactivity is retained; surface may retain greater bioactivity over time in vivo; Simultaneously supports endothelialization; can be stored for long periods, following freeze drying, and retains effectiveness when rehydrated and; surface is able to bind many fibrinolytic enzymes such as streptokinase, urokinase, tPA, plasmin).Type: GrantFiled: September 11, 2015Date of Patent: May 28, 2019Assignee: Heart Research Institute, Ltd.Inventors: Steven G. Wise, Martin K. C. Ng
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Patent number: 10300176Abstract: A liquid excipient is added to a lock solution formulation containing a lower alcohol and an anti-coagulant, antibiotic, and/or anti-microbial, such as the ethanol and tri-sodium citrate lock solution formulation, to prevent citrate from crystallizing in catheters made from silicone. The locking solution could include a liquid excipient, such as glycerol, polysorbate-20, or polyethylene glycol (PEG)-400, along with a lower alcohol, such as ethanol, and an anti-coagulant, such as tri-sodium citrate, antibiotic, and/or anti-microbial.Type: GrantFiled: November 25, 2014Date of Patent: May 28, 2019Assignee: Medline Industries, Inc.Inventors: Lecon Woo, William Anderson
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Patent number: 10300177Abstract: A storage container includes a storing section including a storage space and an inflow port, and a water sealing section. The storing section includes an inflow section connectable to a tube and a volume changing section capable of changing the volume of the storage space. The volume changing section is deformed to increase the volume of the storage space when pressure in the storage space is about to rise to be equal to or higher than a reference pressure set in advance and is deformed to reduce the volume of the storage space when the pressure in the storage space is about to drop to be lower than the reference pressure.Type: GrantFiled: December 19, 2014Date of Patent: May 28, 2019Assignee: DAIKEN MEDICAL CO., LTD.Inventors: Keiichi Yamada, Zhonghuan Shen, Kazuki Ishibashi, Masayuki Uruma
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Patent number: 10300178Abstract: A method for providing a negative pressure wherein a pump is cycled on and off to achieve a target negative pressure, which is set slightly lower than the therapeutic negative pressure. A device determines the actual pressure by averaging samples which may occur at a different rate than the pump cycle.Type: GrantFiled: June 11, 2015Date of Patent: May 28, 2019Assignee: Smith & Nephew, Inc.Inventors: John Buan, Richard Willems
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Patent number: 10300179Abstract: A medical device for draining a fluid from the body of a patient includes a tubular member having an open distal end that resides interiorly of the body of a patient and a proximal end that extends exteriorly of the body of the patient. The tubular member has an inner surface extending between the distal end and the proximal end, wherein the inner surface defines a lumen. An interior member is disposed in the lumen and extends along a length of the inner surface. The interior member is engaged with the inner surface such that a chamber is defined therebetween. A conduit is engaged with the tubular member for transmission of an inflation fluid to selectively vary a dimension of the chamber for freeing clogged debris in the lumen.Type: GrantFiled: April 4, 2016Date of Patent: May 28, 2019Assignee: Cook Medical Technologies LLCInventor: Kurt J. Tekulve
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Patent number: 10300180Abstract: A wound-care system includes a first pump fluidly coupled to an oxygen source. An oxygen concentrator is fluidly coupled to the first pump. A humidification system is fluidly coupled to the oxygen concentrator. A wound dressing is fluidly coupled to the humidification system and to an exudate chamber. A negative-pressure tube fluidly is coupled to the exudate chamber. A first valve is disposed between the first pump and the oxygen concentrator. A second valve is disposed between the oxygen concentrator and the wound dressing. A third valve is disposed in the negative-pressure tube. Selective activation of the first pump, the first valve, the second valve, and the third valve facilitates delivery of at least one of individual, sequential, or simultaneous negative-pressure treatment and oxygen-rich fluid treatment to the wound via the wound dressing.Type: GrantFiled: October 11, 2017Date of Patent: May 28, 2019Assignee: ThermoTek, Inc.Inventors: Tony Quisenberry, Sam K. McSpadden, Niran Balachandran, Robert K. Lasalle, Thomas C. Anderson, Kathryn Davis
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Patent number: 10300181Abstract: Manifold structures, systems, and methods are disclosed that include using longitudinal members and one or more shaped projections to cause microstrain at a tissue site. In one instance a manifold structure includes a plurality of spaced longitudinal members and at least one shaped projection coupled to at least one of the plurality of longitudinal members for creating a microstrain at a tissue site. The at least one shaped projection includes a columnar member having a distal end and includes an enlarged member positioned at the distal end of the columnar member. The columnar member has a first outer diameter (D1) and the enlarged member has a second outer diameter (D2). The second outer diameter of the enlarged member is greater than the first outer diameter of the columnar member (D2>D1). Other systems, methods, and structures are presented.Type: GrantFiled: May 26, 2016Date of Patent: May 28, 2019Assignee: KCI Licensing, Inc.Inventors: Timothy Mark Robinson, Christopher Brian Locke, Aidan Marcus Tout
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Patent number: 10300182Abstract: A wound care device includes a flexible cover having a concave interior surface and a flange configured for sealing engagement with the skin of a patient so that the device can be affixed to the skin of the patient. An inlet tube is in fluid communication with the interior thereof and configured to deliver a fluid compound thereto. An outlet tube extends from the flexible cover and is in fluid communication with the interior thereof to allow aspiration of fluid from within the flexible cover. A programmable system delivers one or more of oxygen, saline, medicaments, UV light, and ultrasonic vibration on a schedule predetermined by a user of the device.Type: GrantFiled: March 14, 2017Date of Patent: May 28, 2019Inventor: Harjeet S Brar
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Patent number: 10300183Abstract: The present disclosure provides devices and methods for harvesting and processing tissue from patients for grafting. The devices can include a tissue collection chamber for ascetically collecting, processing, and/or re-implanting adipose tissue.Type: GrantFiled: February 2, 2016Date of Patent: May 28, 2019Assignee: LifeCell CorporationInventors: Sangwook Park, Jerome Connor, Aaron Barere
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Patent number: 10300184Abstract: Methods and apparatus for estimating flow rate in a blood circulation assist system employing impeller eccentricity. A method includes magnetically rotating an impeller within a blood flow channel of a blood pump. The impeller is levitated within the blood flow channel transverse to the impeller axis of rotation. A rotational speed for the impeller is determined. At least one impeller transverse position parameter is determined. The at least one impeller transverse position parameter is based on at least one of (1) an amount of a bearing current that is used to levitate the impeller transverse to the impeller axis of rotation, and (2) a position of the impeller within the blood flow channel transverse to the impeller axis of rotation. A flow rate of blood pumped by the blood pump is estimated based on the impeller rotational speed and the at least one impeller transverse position parameter.Type: GrantFiled: January 17, 2018Date of Patent: May 28, 2019Assignee: TC1 LLCInventor: Christopher J. Cotter
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Patent number: 10300185Abstract: An improved intravascular blood pump and related methods involving the broad inventive concept of equipping the intravascular blood pump with guiding features such that the intravascular blood pump can be selectively positioned at a predetermined location within the circulatory system of a patient.Type: GrantFiled: October 5, 2018Date of Patent: May 28, 2019Assignee: MAQUET CARDIOVASCULAR LLCInventors: Walid N. Aboul-Hosn, William R. Kanz, Bruce A. Baker
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Patent number: 10300186Abstract: An improved intravascular blood pump and related methods involving the broad inventive concept of equipping the intravascular blood pump with guiding features such that the intravascular blood pump can be selectively positioned at a predetermined location within the circulatory system of a patient.Type: GrantFiled: October 12, 2018Date of Patent: May 28, 2019Assignee: MAQUET CARDIOVASCULAR LLCInventors: Walid N. Aboul-Hosn, William R. Kanz, Bruce A. Baker
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Patent number: 10300187Abstract: A hose mount of a blood treatment machine, having a hose connection element as a component of the machine's internal hosing including at least one rigid sleeve portion that is adapted to position a flexible hose radially outside over the free end of the at least one sleeve portion, an axial stop formed or arranged on the outer circumference of the sleeve portion at a distance from the free end, and a flexible collar arranged or formed on the at least one sleeve element toward the free end with an axial distance to the axial stop in order to define an external circumferential groove between itself and the axial stop.Type: GrantFiled: May 31, 2016Date of Patent: May 28, 2019Assignee: B. Braun Avitum AGInventor: Swetlana Lisitschew
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Patent number: 10300188Abstract: An Autologous fibrin is prepared extemporaneously from either a full blood sample or a prepared sample of poor platelet plasma wherein the latter is subjected to a dedicated treatment and combined isolation process performed by a removable single-use device wherein blood or plasma components are separated and subsequently treated individually to be eventually combined by the user outside the system. The system includes a platform and a removable single-use device both being designed to cooperate mechanically.Type: GrantFiled: June 2, 2014Date of Patent: May 28, 2019Assignee: AVANCE MEDICAL SÀRLInventors: Michael Joos, Peter Everts
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Patent number: 10300189Abstract: A system and method are provided for controlling fouling and complement protein activation during separation of plasma from whole blood using a spinning membrane separator. The separator includes a pair of relatively rotating surfaces spaced apart to define a gap therebetween, with at least one of the surfaces comprising a membrane that allows plasma to pass therethrough but substantially prevents the passage of red cells. In accordance with the method, the membrane material and membrane fabrication technique are selected so as that the resulting membrane both resists fouling and complement protein activation. In a specific embodiment, the membrane is has a smooth surface and substantially linear pores. The pores have a nominal diameter of less than 2 microns (so as to exclude platelets) and preferably a diameter of from 0.6 microns to 0.8 microns, as may be obtained by use of track-etching.Type: GrantFiled: April 30, 2014Date of Patent: May 28, 2019Assignee: Fenwal, Inc.Inventors: Benjamin E. Kusters, Kyungyoon Min, Christopher J. Wegener, Daniel R. Boggs
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Patent number: 10300190Abstract: Methods and extracorporeal blood treatment systems reposition a diaphragm of a pressure measurement apparatus (e.g., a pressure pod apparatus of an extracorporeal blood set) by, for example, controlling an air pump apparatus to move the diaphragm toward a target measuring position based on a calculated target air volume (e.g., wherein the calculated target air volume is representative of the air volume necessary to move the diaphragm to the target measuring position based at least on a monitored air pressure). For example, after the diaphragm is bottomed out or topped out, as air is added to or removed from the transducer side cavity of a pressure pod apparatus, the target air volume may be iteratively calculated until it is determined that the diaphragm is repositioned in the target measuring position.Type: GrantFiled: December 16, 2013Date of Patent: May 28, 2019Assignee: Gambro Lundia ABInventors: Rickie L. Stuva, John O'Mahony
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Patent number: 10300191Abstract: A blood purification apparatus comprising: a blood circuit including an arterial blood circuit and a venous blood circuit and that is capable of extracorporeally circulating blood of a patient from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a blood purification device provided between the arterial and the venous blood circuit of the blood circuit and that is capable of purifying the blood flowing in the blood circuit; a dialysate introduction line for introducing dialysate into the blood purification device and a dialysate drain line for discharging drain liquid from the blood purification device; a liquid delivery pump provided to the dialysate introduction line and that is capable of causing the dialysate in the dialysate introduction line to flow; a heating device that is capable of heating the dialysate to be introduced from the dialysate introduction line into the blood purification device; a temperature-detecting device that is capable of detecting a temperatType: GrantFiled: January 18, 2018Date of Patent: May 28, 2019Assignee: Nikkiso Company LimitedInventors: Hiroaki Mochizuki, Harutoshi Okabe, Sumiaki Matsuo
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Patent number: 10300192Abstract: A device is described for supplying and metering a fluid for medical purposes, at least comprising one pump for pumping the fluid and at least one element through which the fluid is conveyed. At least one recess is provided in the at least one element, which is tightly covered by a sensor component composed of a pressure sensitive material, wherein a material of the at least one element is harder than that of the sensor component. The device also has a force sensor with which pressure-induced changes of the sensor component in a region of the at least one recess can be measured.Type: GrantFiled: November 6, 2012Date of Patent: May 28, 2019Assignee: B. BRAUN MELSUNGEN AGInventor: Dietmar Eberhard
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Patent number: 10300193Abstract: A controller for a programmable medical pump is configured to select a drug library file that corresponds to a received medication name and determine a number of times status information is received within a designated time period from a current time during an infusion therapy. The example controller is also configured to determine if the number of times the status information is received comports with an accumulated medication dosage limit using a dose per administration program parameter. Responsive to the number of times the status information is received matching or exceeding the accumulated medication dosage limit, the controller is configured to prevent another administration of the medication until enough time has passed such that the number of times the status information has been received within the designated time period from the current time is less than the accumulated medication dosage limit.Type: GrantFiled: June 12, 2017Date of Patent: May 28, 2019Assignee: Baxter International Inc.Inventors: Janice Stewart, Randolph Meinzer, Debra K. Bello, Janet Mullan, James D. Jacobson, Tuan Bui, Qui Chau
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Patent number: 10300194Abstract: A patient care system is disclosed that includes a medical device such as an infusion pump. The medical device generates a data message containing information such as the status of the therapy being delivered, operating data or both. An alarm generating system assesses the data message from the pump and generates an alarm message if certain conditions established by a first set of rules are met. The alarm message is assessed according to a second set of rules as to whether to suppress the alarm message. The data message contains a required input for both the first and second algorithms. A dispatching system is adapted to forward the alarm message to an alarm destination according to a third set of rules. The alarm destination expresses an alarm upon receipt of the alarm message.Type: GrantFiled: August 11, 2017Date of Patent: May 28, 2019Assignee: ICU Medical, Inc.Inventors: William Kenneth Day, Steve Joseph Lindo, Paul John Foryt, Justin Joseph Schmidt, Robert Cousineau, Michael Kremliovsky, Sumant Ramachandra, Anatoly S. Belkin, Gary Mills
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Patent number: 10300195Abstract: A method of operating an infusion device that includes the steps of actuating a fluid transfer device, which is configured to deliver a predetermined volume during each actuation, in accordance with a delivery profile that includes a plurality of fluid transfer device actuations, determining, based on sensed pressure, whether an actual volume delivered during a fluid transfer device actuation is the predetermined volume, and adjusting the number of actuations in the delivery profile in response to the actual volume delivered differing from the predetermined volume.Type: GrantFiled: January 19, 2017Date of Patent: May 28, 2019Assignee: Medallion Therapeutics, Inc.Inventors: Christian M. Merot, Pedrum Minaie
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Patent number: 10300196Abstract: A fluid medicament delivery device includes a patient attachment unit and a separate indicator unit. The patient attachment unit includes a housing and a fluid channel located therein, wherein at least a portion of the fluid channel includes a flexible member substantially coterminous with the housing. The separate indicator unit is adapted to be detachably coupled to the housing of the patient attachment unit and includes a first sensing element for contacting the flexible member when the indicator unit is coupled to the housing to sense a flexure of the flexible member.Type: GrantFiled: May 21, 2015Date of Patent: May 28, 2019Assignee: CeQur SAInventors: Peter Gravesen, Heiko Arndt, Serguei Chiriaev
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Patent number: 10300197Abstract: A dropping rate measuring device for measuring a flow rate of liquid droplets which grow on a lower end of a nozzle and intermittently drop from the lower end of the nozzle includes an imaging unit that images a growing liquid droplet which is growing on the lower end of the nozzle at a plurality of time points and acquires a plurality of pieces of image data of the growing liquid droplet, and a data processor that calculates the flow rate by analyzing the plurality of pieces of image data acquired by the imaging unit.Type: GrantFiled: July 12, 2017Date of Patent: May 28, 2019Assignee: MURATA MANUFACTURING CO., LTD.Inventors: Atsuhiko Hirata, Nobuhiro Kondo, Yuzo Higashiyama, Yoshitaka Hane, Yoshihide Amagai
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Patent number: 10300198Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap opens a rotary valve allowing for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the reconstituted drug after the mixing stage is complete.Type: GrantFiled: December 5, 2017Date of Patent: May 28, 2019Assignee: Windgap Medical, Inc.Inventors: Cole Constantineau, Christopher J. Stepanian, Adam R. Standley, Michel Bruehwiler, Brent Buchine, Jeffrey Thomas Chagnon, Robert Brik
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Patent number: 10300199Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a sliding valve and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.Type: GrantFiled: December 5, 2017Date of Patent: May 28, 2019Assignee: Windgap Medical, Inc.Inventors: Adam R. Standley, Christopher J. Stepanian, Cole Constantineau, Michel Bruehwiler, Brent Buchine, Jeffrey Thomas Chagnon, Robert Brik
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Patent number: 10300200Abstract: A automatic injection device including a housing, a firing mechanism, a near-field communication (NFC) assembly, a syringe, and a plunger. The firing mechanism is disposed within the second end of the housing and includes an activation button moveable relative to the firing body between an initial position and an actuated position. The activation button is configured to deploy the plunger when actuated. The firing mechanism includes a piercing element extending from at least the firing body or the activation button. The NFC assembly includes a film disposed proximate the piercing element and configured to be pierced by the piercing element upon actuation of the activation button. The NFC circuit is configured to indicate a film status including at least an unpierced film status before the film is pierced and a pierced film status after the film is pierced. A method of using the automatic injection device is also disclosed.Type: GrantFiled: February 27, 2018Date of Patent: May 28, 2019Assignee: AbbVie Inc.Inventors: James J. Hughes, Bhimaprasad Medhal
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Patent number: 10300201Abstract: A low retraction activation force plunger sub-assembly for an automatic injector includes: a plunger outer having one or more engagement prongs, a plunger inner having a shoulder, and a plunger biasing member retained in a first energized state between said plunger outer and plunger inner when the engagement prongs of the plunger outer are releasably engaged with the shoulder of the plunger inner. An automatic injector includes a housing, an activation mechanism, an actuation mechanism, and a syringe cartridge having the plunger sub-assembly and a needle assembly, wherein the actuation mechanism includes comprises an actuation biasing member residing in an initial energized state substantially within an upper portion of an actuation pill. A method of assembling the automatic injector includes the steps of: assembling the plunger sub-assembly and inserting the plunger sub-assembly into the housing such that a proximal end of the plunger sub-assembly contacts the actuation pill.Type: GrantFiled: February 6, 2013Date of Patent: May 28, 2019Assignee: UNL Holdings LLCInventors: Katlin M. Lumme, Philip A. Weaver