Patents Issued in May 28, 2019
  • Patent number: 10300252
    Abstract: A catheter devices/systems and methods therefrom are described herein for treating acute kidney injury, especially the contrast-induced acute kidney injury wherein the devices prevent the contrast dyes from entering into kidney and/or facilitate blood flow of kidney by said catheter system.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: May 28, 2019
    Assignee: RenalPro Medical, Inc.
    Inventors: Tsung-Chun Lee, Wen-Pin Shih
  • Patent number: 10300253
    Abstract: Method of forming a multiple balloon catheter includes extruding a tube and a plurality of ribs through a die to form a monolithic element that spans between first and second ends with the plurality of ribs extending along the length of the tube to define a corresponding number of a plurality of channels that extend along the length of the tube. Positioning a portion of the tube into a mold and constricting a proximal end portion and a distal end portion of the tube that is positioned in the mold. Inflating the tube to produce an inner balloon having a body portion that spans between proximal and distal end portions and cutting the inner balloon to separate the inner balloon from a remainder of the tube. Disposing an outer balloon including a plurality of holes around the inner balloon and aligning the plurality of holes with the plurality of channels.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: May 28, 2019
    Assignee: Cook Medical Technologies LLC
    Inventor: Per Elgaard Pederson
  • Patent number: 10300254
    Abstract: Various systems and methods are provided for treating pulmonary edema. In general, a pump can be configured to be implanted within a patient at risk of developing edema. The pump can be configured to pump fluid out of the patient's lungs, e.g., out of the patient's interstitial and alveolar spaces. The pump can be configured to be fully implanted within the patient's body. The pump can be configured to continuously pump fluid, or the pump can be configured to be selectively actuatable in response to a trigger event. In an exemplary embodiment, the pump can include an inflow port coupled to an inflow tube in fluid communication with a lymphatic vessel of the patient, and can include an outflow port coupled to an outflow tube in fluid communication with a vein of the patient.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: May 28, 2019
    Assignee: White Swell Medical Ltd
    Inventors: Yaacov Nitzan, Menashe Yacoby, Tanhum Feld
  • Patent number: 10300255
    Abstract: An intercostal-pump based fluid management system, as described herein, comprises an intercostal pump that is, generally, a resiliently flexible bulb having an inlet and an outlet. The inlet is attached to a first tube that extends from the intercostal pump to a first area of a patient's body, for example, the patient's pleural cavity. The outlet is connected to a second tube that extends from the intercostal pump to a second area of a patient's body, for example, the patient's peritoneal cavity. In use, the intercostal pump is placed between a first rib and a second rib in a patient. The intercostal pump operates by being successively compressed and decompressed between the first and second ribs as the patient breaths.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: May 28, 2019
    Inventors: Martin Mayse, Ryan Smith, Chris Butts
  • Patent number: 10300256
    Abstract: In some embodiments, a medical device for recanalizing a vessel having a blockage and restoring blood flow through an obstructed blood vessel includes an expandable member coupled to a core wire and a hypotube that are movable relative to each other to manipulate the expandable member between various configurations. The expandable member having a capture structure in an expanded configuration. The expandable member can include multiple interstices formed by woven mesh filaments or braided strands through which the material blocking the vessel can pass. The capture structure can include a shape on its external surface that facilitates dislodgement and capture of the material within capture spaces created by the expandable member. Some embodiments include a capture sack or cap for capturing material and preventing material from migrating down stream of the blockage. Superoxygenated blood can be infused distal to the blockage to minimize loss of function during an ischemic event.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: May 28, 2019
    Assignee: COVIDIEN LP
    Inventor: Maria Aboytes
  • Patent number: 10300257
    Abstract: A dilation assembly includes a shaft and a dilator coupled with the distal end of the shaft. The dilator includes a proximal end, a distal end, and a center portion positioned between the proximal end and the distal end. The center portion dilates from a first configuration to a second configuration. The center portion has a larger diameter than the proximal end and the distal end when the center portion is in the second configuration. At least one gripping feature is positioned on at least a portion of the exterior surface of the center portion. The gripping feature provides friction between the center portion and a bodily lumen when the center portion is in the second configuration.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: May 28, 2019
    Assignee: Acclarent, Inc.
    Inventors: Show-Mean Wu, Tapan Mistry, Dexter D. Hernando, Siddhi K. Desai, Robert J. Tannhauser, Shrirang V. Ranade, Ketan P. Muni, Martin J. Madden, Andrew Chen
  • Patent number: 10300258
    Abstract: An apparatus for natural treatment for middle ear infection has a single use sachet. The sachet has a pocket that holds a limited quantity of mustard essential oil. The sachet has a neck and a dropper and the sachet can be squeezed to flow drops for pouring into an ear canal. The sachet is put in a microwave oven just before use for only substantially 30 seconds to heat the oil and up to five drops of heated oil is squeezed into an ear canal of a person with severe ear itching indicative of a middle ear infection.
    Type: Grant
    Filed: March 25, 2013
    Date of Patent: May 28, 2019
    Inventor: Tara Chand Singhal
  • Patent number: 10300259
    Abstract: A remotely activatable capsule. The capsule includes a housing that can be swallowed by a subject, an electrical energy reservoir having a first terminal and a second terminal positioned in the housing, a remotely activatable switch positioned in the housing and configured to be remotely activated, and a function-specific mechanism positioned in the housing and electrically coupled to the remotely activatable switch and to the electrical energy reservoir and configured to perform a function when the remotely activatable switch is activated.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: May 28, 2019
    Assignee: Purdue Research Foundation
    Inventors: Babak Ziaie, Rahim Rahimi, Wuyang Yu
  • Patent number: 10300260
    Abstract: An applicator and method for applying a microneedle device to skin. The applicator can include a microneedle device and a housing configured to house the microneedle device. The housing can have a first surface configured to be positioned toward the skin. The applicator can include (i) an unactuated state in which the microneedle device is located within the housing and does not extend beyond the first surface of the housing, and (ii) an actuated state in which at least a portion of the microneedle device extends beyond the first surface of the housing. The applicator can further include a locking mechanism configured to lock the applicator in the actuated state. The method can include positioning the first surface of the housing of the applicator adjacent the skin; actuating the applicator to cause the applicator to change to the actuated state; and locking the applicator in the actuated state.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: May 28, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: David J. Wirtanen, Kevin L. Puckett, James L. Schug
  • Patent number: 10300261
    Abstract: A method for producing a needle-shaped body having needles on a first surface of a substrate made of a thermoplastic resin, the method including the steps of: forming the needle-shaped body by filling the thermoplastic resin into a duplication plate having recesses that correspond to shapes of the needles; providing a support member made of a material different from a material for the needle-shaped body on a second surface of the substrate which is opposite to the first surface; and removing the needle-shaped body and the support member which are integrally formed from the duplication plate.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: May 28, 2019
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventor: Kazuhiko Shiomitsu
  • Patent number: 10300262
    Abstract: An access port, wherein the access port may include a body having an exterior surface and a chamber defined therein, a bore defined in the body providing fluid communication between the chamber and the exterior surface, a needle in fluid communication with the chamber, a passage defined in the body providing communication between the chamber and the exterior surface, a seal secured within the passage, and an actuator in communication with the needle, configured to move the needle relative to the passage or move the passage relative to the needle.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: May 28, 2019
    Assignee: Versago Vascular Access, Inc.
    Inventors: Steven J. Tallarida, Kenneth Arden Eliasen
  • Patent number: 10300263
    Abstract: A closure assembly structured to be attached in flow restricting relation to a medical connector and removed therefrom utilizing a push-on and twist-off manipulation. The closure assembly comprises a cap having a preferably male flow restricting portion, wherein the cap is operatively disposed in removable, flow restricting attachment to a female medical connector. A plurality of segments collectively define a sidewall of the cap and are individually and collectively movable between an open orientation and a closed orientation relative to at least the flow restricting portion and a medical connector attached thereto. The closed orientation comprises the plurality of segments disposed in covering, retaining relation to the attached medical connector and the open orientation comprises an outward disposition of the plurality of segments and an accessible, exposure of the flow restricting portion. A tamper evident structure may be operatively associated with a housing assembly of the closure assembly.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: May 28, 2019
    Inventor: Timothy Brandon Hunt
  • Patent number: 10300264
    Abstract: Disclosed herein is a fluid infusion device of the type that delivers medication fluid to the body of a patient. The device includes or cooperates with a fluid reservoir, and the device has a sealing assembly to receive and form a fluid seal with the fluid reservoir. A retractable sealing element surrounding a hollow fluid delivery needle may be used to seal a port of the fluid reservoir. The port may include a pressure vent that is sealed by the retractable sealing element. In one variation, the reservoir includes a moving valve sleeve that holds a septum. The septum moves to allow the reservoir to vent, and to form a seal with the port when the needle pierces the septum. In another variation, the device includes a needleless sealing assembly. In yet other variations, the device uses a needled fluid reservoir.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: May 28, 2019
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Edgardo C. Halili, Eric M. Lorenzen, Matthew William Yavorsky
  • Patent number: 10300265
    Abstract: A needleless connector includes a body having a fluid path, a vent path, and a male fitting. The needleless connector also includes a valve disposed within the male fitting. The valve is configured to move between a first configuration, in which the fluid path is blocked, and a second configuration, in which the fluid path is open. The needleless connector further includes a seal disposed around the valve. The seal is configured to separate the fluid path from the vent path in the first and second configurations. Moving the valve from the first configuration to the second configuration also opens the vent path. The seal maintains the separation between the fluid path and the vent path when the valve moves from the first configuration to the second configuration.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: May 28, 2019
    Assignee: CAREFUSION 303, INC.
    Inventors: George Michel Mansour, Tyler Devin Panian
  • Patent number: 10300266
    Abstract: An electrode system includes a gel deployment receptacle configured to release a conductive gel onto a body of a subject and a fluid pump in fluid communication with the gel deployment receptacle.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: May 28, 2019
    Assignee: ZOLL MEDICAL CORPORATION
    Inventors: Thomas E. Kaib, Gary A. Freeman, Phillip Hier Amsler
  • Patent number: 10300267
    Abstract: The disclosure relates to a lead including a connector for connection to a generator, a demultiplexing circuit receiving at its input on the first conductors of the electrical control signals from the control bus and whose output is connected to a plurality of second conductors contained in the lead and connected to the lead electrodes. The lead further includes a gate and connection circuit component having a body forming a support for an integrated circuit for demultiplexing and defining a set of connection cavities with the second conductor distributed at the periphery of the body around a general axis of the body, and a plurality of connecting elements embedded in the body material, and emerging at an element region and supporting the circuit at respective cavities. The gate and connection circuit component is advantageously made of ceramic-metal.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: May 28, 2019
    Assignee: Sorin CRM SAS
    Inventors: Nicolas Shan, Philippe D'Hiver
  • Patent number: 10300268
    Abstract: Devices and methods provide accurate targeting, placement, and/or stabilization of an electrode or other instrument(s) into the brain or other body organ, such as to treat severe tremor or other neurological disorders. Targeting is performed using any form of image-guidance, including real-time MRI, CT, or frameless surgical navigation systems.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: May 28, 2019
    Assignees: Medtronic, Inc., Mayo Foundation for Medical Education and Research
    Inventors: James Skakoon, Robert Wharen, Matthew Solar, Kari Parmer, Rudy A. Mazzocchi, John David, Frank Murdock, David Hatcher, Thomas I. Miller, Timothy Parmer, Charles Truwit
  • Patent number: 10300269
    Abstract: A system for neuromodulation device coding for stimulation of a patient includes a neural code library comprising digital representations of neural responses of neural units of at least one normal functioning animal, each digital representation corresponding to one of digital representations of stimulus; a sensory device configured to detect a sensory signal; an analyzer configured to identify one of the digital representations of stimulus in the neural code library in response to receipt of the sensory signal; a processing device configured, for each identified sensory signal, to retrieve the digital representations of neural responses of neural units corresponding to the identified sensory signal from the neural code library, and select one or more neural units of a patient to be stimulated by a neuromodulation device associated with the patient; and a transmitting device configured to stimulate the selected one or more neural units of the patient.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: May 28, 2019
    Assignees: NORTHWESTERN UNIVERSITY, RESONANCE MEDICAL, LLC
    Inventors: Claus-Peter Richter, Chris Heddon, Petrina LaFaire, Brian Dougherty
  • Patent number: 10300270
    Abstract: The present invention is related to an implantable medical device for treating breathing disorders and cardiac disorders by delivering stimulation energy to the phrenic nerve, hypoglossal nerves and cardiac muscle tissues.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: May 28, 2019
    Assignee: Respicardia, Inc.
    Inventors: Mark Gelfand, Howard R. Levin
  • Patent number: 10300271
    Abstract: An EMS training device includes an EMS stimulus generating unit for generating EMS stimuli following a specified excitation pattern with current pulses and/or an alternating current. EMS electrodes are attached to a living body in pairs for applying the EMS stimuli to the body. Line branches connect the EMS electrodes to the EMS stimulus generating unit to apply the EMS stimuli to corresponding EMS electrodes such that a current with a specified amplitude and frequency pattern is conducted through the body. To protect the EMS electrodes and/or other susceptible elements of the line branches from corrosion, the EMS training device has at least one measuring device for measuring a value of a resistance in the line branch, a comparison device for comparing the value with a target value, and at least one compensation device for compensating for a deviation of the actual value from the target value.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: May 28, 2019
    Assignee: Miha Bodytec GmbH
    Inventors: Hansjürgen Horter, Jürgen Decker
  • Patent number: 10300272
    Abstract: A system and method are presented that electrically stimulates the phrenic nerve whereby said stimulation results in muscle activation of the diaphragm as observed by a measurement of work or power of breathing associated with the inspiratory portion of a stimulated breath.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: May 28, 2019
    Assignee: Stimdia Medical, Inc.
    Inventors: John O'Mahony, Patrick J. Wethington
  • Patent number: 10300273
    Abstract: Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: May 28, 2019
    Assignee: Medtronic, Inc.
    Inventors: Ethan A. Rooney, Carl D. Wahlstrand, Gary W. King, Thomas E. Cross, Jr., Kenneth T. Heruth, Paul W. Wacnik, Jeffrey S. Evanson
  • Patent number: 10300274
    Abstract: A signal processing arrangement generates electrode stimulation signals to stimulation contacts in a cochlear implant electrode array. A signal filter bank transforms an input sound signal into band pass signals, which each represent an associated frequency band of audio frequencies. An envelope processing module processes the band pass signals in a sequence of sampling time frames, wherein for each time frame, the processing includes calculating for each band pass signal at least one signal envelope dynamic property that is changing during the time frame. A channel selection module selects one or more of the band pass signals for each time frame based on the dynamic properties to produce the electrode stimulation signals to the stimulation contacts.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: May 28, 2019
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventors: Dirk Meister, Mathias Kals, Peter Schleich
  • Patent number: 10300275
    Abstract: Apparatus and methods for installing a magnet into a cochlear implant.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: May 28, 2019
    Assignee: Advanced Bionics AG
    Inventors: Steve Hazard, Sarah Elizabeth Clabeaux, Charles C. Finley, Lee F. Hartley
  • Patent number: 10300276
    Abstract: A cochlear implant is disclosed including a cochlear lead, an antenna, a stimulation processor, a magnet apparatus, associated with the antenna, including a case, a divider, and a plurality of magnetic material particles that are movable relative to one another within sub-volumes defined by the divider.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: May 28, 2019
    Assignee: Advanced Bionics AG
    Inventors: Sung Jin Lee, James George Elcoate Smith
  • Patent number: 10300277
    Abstract: Variable amplitude signals for neurological therapy, and associated systems and methods are disclosed. A representative method includes activating automatic delivery of an electrical therapy signal to a patient's spinal cord region at a frequency in a frequency range between 1.5 kHz and 100 kHz, via at least one signal delivery contact carried by an implanted signal delivery device. The delivery can include repeatedly and automatically delivering the electrical therapy signal at each of multiple therapy signal amplitudes to the at least one signal delivery contact, without the therapy signal generating paresthesia in the patient. The foregoing process can be used as a screening tool to screen responders from non-responders in the context of a non-paresthesia-generating therapy, and/or can be used during long-term treatment, for example, for chronic pain.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: May 28, 2019
    Assignee: Nevro Corp.
    Inventor: Chris Dawson
  • Patent number: 10300278
    Abstract: A method of operating an implantable neuromodulator includes calculating an index for each of a plurality of modulation parameter sets, wherein each modulation parameter set includes a respective plurality of modulation parameters from which the respective index is calculated, serially conveying electrical modulation energy to a patient in accordance with each of the plurality of modulation parameter sets, causing the patient to perceive paresthesia in response to the conveyance of the electrical modulation energy to the tissue in accordance with one of the plurality of modulation parameter sets, identifying the calculated index for that one modulation parameter set as a perception threshold index based on the perceived paresthesia, and storing the identified perception threshold index.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: May 28, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Sarvani Grandhe
  • Patent number: 10300279
    Abstract: Systems and methods are provided for treating a sexual disorder such as erectile dysfunction (ED) or female sexual arousal disorder (FSAD). An electrical stimulation system may include an implantable stimulation unit, an external patient controller, and an external physician controller. The implantable stimulation unit has an array of electrodes disposed on one or more flexible substrates configured to conform to a patient's anatomy at the pelvic plexus. Post-implantation, the physician controller may direct the stimulation unit to stimulate with select electrode(s) of the array to determine which electrode configuration provides optimal sexual arousal. The patient controller may be used to cause the stimulation unit to stimulate using the optimal electrode configuration at desired times.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: May 28, 2019
    Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Rodrigo Araujo Fraga {grave over (d)}a Silva, Nikolaos Stergiopulos
  • Patent number: 10300280
    Abstract: An active implantable medical device includes a VNS pulse bursts generator for stimulation of the vagus nerve according to several selectable configurations. The device may further include a sensor of the current activity level of the patient. The generator is controlled on the activity signal via a classifier determining the of class the current level of activity among a plurality of classes of activity. A controller selects a configuration of VNS therapy depending on the class of activity thus determined. Limits of the activity classes are dynamically changeable by a calibration module that conducts a historical analysis of the successive current activity levels over a predetermined analysis period. The calibration module can prepare a histogram of the historical analysis, and can define the limits of the activity classes depending on the outcome of the historical analysis and the histogram.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: May 28, 2019
    Assignee: Sorin CRM SAS
    Inventor: Jean-Luc Bonnet
  • Patent number: 10300281
    Abstract: This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: May 28, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Michael J. Joyner, Bruce D. Johnson, Thomas P. Olson
  • Patent number: 10300282
    Abstract: Electrical stimulation therapy is provided to a patient in order to induce a patient sensation. The patient sensation may be selected from a number of patient sensations. A set of therapy parameter values are associated with each of the number of patient sensations. A user interface allows a user to adjust one or more characteristics of the patient sensation.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: May 28, 2019
    Assignee: Medtronic, Inc.
    Inventors: Nathan A. Torgerson, Kevin L. Bright, Nicholas D. Buse
  • Patent number: 10300283
    Abstract: A device determines values for one or more metrics that indicate the quality of a patient's sleep based on sensed physiological parameter values. Sleep efficiency, sleep latency, and time spent in deeper sleep states are example sleep quality metrics for which values may be determined. The sleep quality metric values may be used, for example, to evaluate the effectiveness of a therapy delivered to the patient by a medical device. In some embodiments, determined sleep quality metric values are automatically associated with the therapy parameter sets according to which the medical device delivered the therapy when the physiological parameter values were sensed, and used to evaluate the effectiveness of the various therapy parameter sets. The medical device may deliver the therapy to treat a non-respiratory neurological disorder, such as epilepsy, a movement disorder, or a psychological disorder. The therapy may be, for example, deep brain stimulation (DBS) therapy.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: May 28, 2019
    Assignee: Medtronic, Inc.
    Inventors: Keith A. Miesel, Kenneth T. Heruth, Jonathan C. Werder, Steve R. LaPorte, Nina M. Graves
  • Patent number: 10300284
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: May 28, 2019
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
  • Patent number: 10300285
    Abstract: Electrical stimulation sources and amplitudes are allocated to implantable electrodes based on impedance values for controlled delivery of electrical stimulation therapy to a patient. Allocation may include assigning implantable electrodes, in a group of active electrodes, to clusters based on impedance values of the electrodes, coupling the electrode clusters to respective stimulation sources, and defining respective stimulation amplitudes delivered by the stimulation sources to the electrode clusters. Each cluster may include electrodes having relatively similar impedance values, such that electrodes in each cluster present less variation in impedance relative to impedance variation across the group of electrodes. With reduced variation in impedance, in some examples, variation in current outflow through electrodes in each cluster may be reduced, promoting more uniform distribution of stimulation current across the group of active electrodes and a more uniform stimulation field.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: May 28, 2019
    Assignee: Medtronic Bakken Research Center B.V.
    Inventors: Mattias Bengt Johan Astrom, Mark Hage, Hubert Cecile François Martens, Kambiz Nanbakhsh, Erik van Veenendaal
  • Patent number: 10300286
    Abstract: A tool has an outer assembly, which includes a deployment tube, extending around, and moveable with respect to an inner assembly of the tool; the inner assembly includes a single pull wire and a distal member configured to engage an end of an implantable medical device. The deployment tube includes an articulating segment located just proximal to an enlarged distal-most portion, which contains the device and the distal member. Relatively soft and stiff sections of a composite sidewall define the articulating segment and extend alongside one another, such that, when the pull wire is actuated, the composite sidewall causes bending of the segment in two directions. A handle assembly of the tool includes a control member for the pull wire, and may further include a flushing subassembly that has a connector port located at an end of the handle assembly that is opposite a proximal port of the handle.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: May 28, 2019
    Assignee: Medtronic, Inc.
    Inventors: Sean Ward, Rónán Wood, Gwenda McMullin, Paula McDonnell, Aram Jamous
  • Patent number: 10300287
    Abstract: A delivery system for an implantable medical device includes a tool and a tethering member extending side-by-side within an inner shaft thereof; the tool extends within a first lumen, being in sliding engagement therein, and includes a distal end coupling feature that protrudes from a distal end of the inner shaft; and the tethering member has a first segment extending within a second lumen, and a second segment extending from the first segment and distally from the distal end of the inner shaft to an end of the tethering member, which is configured to engage with a holding member of the device, and with which the coupling feature of the tool is configured to couple. A retainer may be joined to another end of the tethering member that protrudes from a proximal port of the system.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: May 28, 2019
    Assignee: Medtronic, Inc.
    Inventors: Jeffrey Madden, Tomas K Kelly, John Gallagher, Gwenda Francis, Brendan Patrick Geraghty, Francis Denis McEvoy, Barry O'Connell, Rónán Wood
  • Patent number: 10300288
    Abstract: The disclosure herein is directed toward systems and methods for pairing two or more devices into a wireless network and transferring data between two or more electro-stimulation devices. Specifically, the systems and methods disclosed herein may include pairing two or more devices into a network configuration using, in part, a pairing device to distinctly identify the devices to be paired and to pair the identified devices into a network. Moreover, the systems and methods disclosed herein may include transferring data between two or more devices using, in part, one or more electro-stimulation contacts for electro-stimulation therapy and using, in part, the same one or more electro-stimulation contacts for transferring data between two or more devices.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: May 28, 2019
    Assignee: Empi, Inc.
    Inventors: Flavien Baumgartner, Stéphane Perroud, Philippe Vuadens, Nicolas Fontaine
  • Patent number: 10300289
    Abstract: This document discusses, among other things, an implantable dielectric compartment including a channel in an outer surface of the implantable dielectric compartment, the channel configured to constrain a portion of an implantable antenna in a specific configuration along the length of the portion of the implantable antenna. In certain examples, the implantable antenna can be configured to wirelessly transfer information electromagnetically at a specified operating frequency provided using the specific configuration of the portion of the implantable antenna.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: May 28, 2019
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Mark G. Deehr, David A. Chizek, Mahesh Maddali, Dennis Eric Larson, Keith Raymond Maile
  • Patent number: 10300290
    Abstract: Aspects are generally directed to techniques for determining weights for stimulation channels of a stimulating hearing prosthesis. The determined weights are used to provide stimulation to a recipient of the stimulating hearing prosthesis.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: May 28, 2019
    Assignee: Cochlear Limited
    Inventors: Zachary M. Smith, Christopher van den Honert
  • Patent number: 10300291
    Abstract: Implantable medical devices include header structures with conductive paths from the feedthrough conductors that may be located on one side of the device to electrical connectors that may be located on an opposite side of the device. The conductive paths may include conductive interconnect pins and lead frame conductors. The conductive interconnect pins may be located in holes present in a header body where the conductive interconnect pins are attached to the feedthrough conductors on one end and are attached to the lead frame conductors on the opposite end. The lead frame conductors then extend to the corresponding electrical connectors. The header body may provide cavities on each side to allow for the insertion of stack assemblies that include the electrical connectors and lead frame conductors.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: May 28, 2019
    Assignee: MEDTRONIC, INC.
    Inventors: Michael J. Baade, Katherine J. Bach, Steven T. Deininger
  • Patent number: 10300292
    Abstract: An apparatus is disclosed, configured to control transmission of wireless energy supplied to an electrically operable medical device adapted to be implanted in a mammal patient. The apparatus comprises an external energy source adapted to be located outside the mammal patient and comprising an external control unit, wherein the external energy source is adapted to transmit wireless energy. Further, the apparatus comprises an internal energy receiver located inside the patient and comprising an internal control unit, wherein the internal energy receiver is adapted to receive the wireless energy and to directly or indirectly supply wirelessly received energy to the electrically operable device. The apparatus further comprises at least one stabilizing unit adapted to stabilize the wirelessly received energy in the electrically operable medical device.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: May 28, 2019
    Inventor: Peter Forsell
  • Patent number: 10300293
    Abstract: This document describes an automated external defibrillator comprising a control configured to switch between a pediatric operating mode and an adult operating mode, wherein each operating mode comprises a mode-specific energy configuration and a mode-specific user configuration; an indicator configured to provide an indication of the operating mode in use during a resuscitation process; one or more processors configured to switch to the mode-specific energy configuration and the mode-specific user configuration upon a change of operating mode between the pediatric operating mode and the adult operating mode such that the automated external defibrillator delivers a defibrillating shock to a patient based on the mode-specific energy configuration; and an interface of the automated external defibrillator provides resuscitation instructions to a user based on the mode-specific user configuration.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: May 28, 2019
    Assignee: ZOLL Medical Corporation
    Inventors: Melissa M. Dascoli, Charles E. Sawyer, Jr., Bill Gastrock, Dustin Boutet, Gary A. Freeman, James Wilson, Brian Stonecipher, Ian Durrant, George Reilly, Mark Bates
  • Patent number: 10300294
    Abstract: It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: May 28, 2019
    Assignee: Nexstim Oyj
    Inventors: Tuomas Neuvonen, Henri Hannula, Gustaf Jarnefelt, Jarmo Laine
  • Patent number: 10300295
    Abstract: A liquid light conducting device used in intervention, comprising a catheter, wherein the inside of the catheter is a cavity, one end of the catheter is provided with a tail sheath, and the other end of the catheter is provided with a liquid-laser coupler which can inject a liquid medium and conduct laser; the tail sheath is provided with an outlet; an inner wall of the catheter is plated with a metal reflecting layer, the liquid medium can be transmitted in the catheter, and laser can be transmitted in the liquid which is coated by the metal reflecting layer and emitted via the tail sheath.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: May 28, 2019
    Inventor: Hua Shang
  • Patent number: 10300296
    Abstract: A swallowable capsule for providing phototherapy to a patient's gastrointestinal (GI) tract, the capsule including a power supply, one or more phototherapeutic light sources, a speed determination unit for calculating speed of movement of the capsule in the GI tract, and a controller unit for activating one or more of the one or more light sources for delivering a therapeutic illumination dose to a target site in the GI tract, based, at least in part, on a determined speed. Related apparatus and methods are also described.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: May 28, 2019
    Assignee: PhotoPill Medical Ltd.
    Inventors: Sharon Ben-Yehuda, Ram Ben-Yehuda
  • Patent number: 10300297
    Abstract: A light-emitting device (100) is disclosed. The light-emitting device (100) comprises a plurality of light-emitting elements (135) or light sources and a power module (120) adapted to selectively convey, supply or provide electrical power to the light-emitting elements (135). The power module (120) may be dimensioned such as to be able to power only a proper subset of the light-emitting elements (135) of the light-emitting device (100) at a given time, the subset having a maximum number of light-emitting elements (135) included therein with respect to the number of light-emitting elements (135) included in the all subsets of the light-emitting elements (135) of the light-emitting device (100).
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: May 28, 2019
    Assignee: SIGNIFY HOLDING B.V.
    Inventors: Jacobos Petrus Johannes Van Os, Tim Dekker, Gerrit Oversluizen, Paul Marcel Carl Lemmens, Frank Anton Van Abeelen, Wouter Hendrik Cornelis Spoorendonk
  • Patent number: 10300298
    Abstract: Phototherapy systems comprising a therapeutic lamp platform for radiant lamps such as LEDs disposed in an assembly including a reflective surface facing towards a patient and a plurality of light apertures substantially aligned with the LEDs for communicating lamp radiation from the lamps to a user. The lamps and associated circuitry are disposed so that the reflective surface is relatively smooth and seamless towards the patient. The walls have a malleable rigidity for flexible adjustability relative to the user, and the device is mounted to the user with a frame.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: May 28, 2019
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Jay Tapper, Lawrence A Blaustein, David Shuter, Eric Freitag, Charles Peter Althoff, Alistair Douglas Bramley, Daniel Joseph Shuter, Zbigniew Paul Lorenc, Allen Zadeh
  • Patent number: 10300299
    Abstract: The present invention relates to methods for treating cell proliferation disorders comprising: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated; (2) administering at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder; and the use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell prolifer
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: May 28, 2019
    Assignees: Immunolight, LLC, Duke University
    Inventors: Frederic A. Bourke, Jr., Tuan Vo-Dinh
  • Patent number: 10300300
    Abstract: A method for generating a radiation treatment plan is provided where uncertainties in the definition of regions of interest are incorporated and utilized by a treatment planning system for optimizing a treatment plan.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: May 28, 2019
    Assignee: RaySearch Laboratories AB
    Inventor: Björn Hårdemark
  • Patent number: 10300301
    Abstract: Provided are a respiratory guiding device (100) and method used in respiratory gated ion beam irradiation, the respiratory guiding device (100) comprising: a respiratory signal detecting unit (101), for measuring a respiratory motion trajectory curve during free breathing and deep breathing, and a real-time respiratory motion position signal in the case of guided respiration; a respiratory signal processing unit (102), for modeling free breathing and deep breathing according to an average respiratory cycle and an average respiratory amplitude calculated on the basis of the respiratory motion trajectory curve and setting a preset breath-hold time at the tail end of a function curve of a free breathing model and a deep breathing model to establish a respiratory guiding curve; a control unit (103), for adjusting the magnetic excitation cycle of a synchrotron according to the respiratory cycle represented by the respiratory guiding curve during free breathing or deep breathing, thus synchronizing the magnetic exc
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: May 28, 2019
    Assignee: INSTITUTE OF MODERN PHYSICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Pengbo He, Qiang Li, Zhongying Dai, Xinguo Liu, Ting Zhao, Tingyan Fu, Guosheng Shen, Yuanyuan Ma, Qiyan Huang, Yuanlin Yan