Abstract: A medicament container carrier comprising a proximal section having a first diameter, a distal section having a second diameter less than the first diameter, and at least one resilient beam arranged in the proximal section and having a beam head protruding radially to form a third diameter. The at least one beam has a non-deflected position in which the third diameter is less than the first diameter and a deflected position in which the third diameter is substantially equal to the first diameter.

Abstract: A priming mechanism for operating an automatic injection apparatus to ensure medication contents are properly delivered prior to a needled syringe of the apparatus being injected. The priming mechanism includes a push rod to move plunger(s) within the syringe; a releasable support including bendable supporting arms, which limiting motion of the syringe relative to an upper housing body before and during priming; and a recess element inside the lower housing body to release said bendable arm to allow motion of the syringe relative to the upper housing body in distal direction after priming. In one form, the priming mechanism is used for removing air bubble before injection to ensure delivering correct dose. In another form, the priming mechanism is used to mix different contents in a dual chamber syringe before injection.

Abstract: A housing blank and an activation member blank for a medicament delivery device are disclosed, with a kit including a housing blank and an activation member blank, and a medicament delivery device assembled from the kit. The housing blank includes a mid portion having a through-opening for receiving a proximal end portion of a medicament container assembly, and first and second legs foldable relative to the proximal end portion. The activation member blank includes a central portion and a first and second arm foldable relative to the proximal end portion.

Abstract: An autoinjector having a body (1; 2), a reservoir (S), a piston (P), a needle (A), and a piston rod (5) co-operating with the piston. The piston rod is movable between a first rest position, a second pricking position, and a third injection position. An actuator spring (6) is provided to urge the piston rod towards its pricking position and then towards its injection position. A force-adjustment system (7, 8) exerts a force (F1, F2) on the piston rod (5). The force (F1) opposes the force exerted by the actuator spring at the end of pricking to decrease the force exerted on the reservoir by the piston rod at the end of pricking, and the force (F2) adding to the force exerted by the actuator spring at the beginning of injection, to amplify the force exerted on the piston by the piston rod at the beginning of injection.

Abstract: A dose setting mechanism for a medicament delivery device is presented having a tubular member, a dose drum, coaxial with the tubular member, and being axially and rotationally movable relative to the tubular member, a stop member, coaxial with the tubular member, and axially movable but rotationally locked relative to the tubular member, and further being axially jointly movable with the dose drum, wherein the stop member has a first stop element and in that the dose drum has a second stop element, and wherein the first stop element and the second stop element are configured to interact with each other to limit rotation of the dose drum to a predetermined angular interval.

Abstract: A dispensing mechanism for delivering a dosage of medicament including a housing having a proximal-distal axis; a plunger rod having a screw thread and configured to advance along the proximal-distal axis relative to the housing; a user-operable push button moveable along the proximal-distal axis relative to the housing; a twist driver threadably engaged with the push button such that movement of the push button towards the distal end of the housing causes rotation of the twist driver about the proximal-distal axis; and a driver engaged with the twist driver such that rotation of the twist driver causes rotation of the driver, the driver also engaged with a portion of the plunger rod such that rotation of the driver causes rotation of the plunger rod, advancing the plunger rod along the proximal-distal axis relative to the housing.

Abstract: A medicament delivery device is presented having a housing with a distal and a proximal end, the housing being adapted to receive a medicament container with a delivery member or with a connectable delivery member for delivery of a medicament. The device also has a drive mechanism arranged to act on a plunger rod, which plunger rod in turn is arranged to act on the medicament container for providing automatic delivery of the medicament and a hold-release mechanism interactively connected to the drive mechanism for releasing the drive mechanism from a biased position. A delayable signal generating mechanism generates an audible and/or tactile and/or visual signal indicating that the medicament has been completely delivered, which delayable signal generating mechanism is operably connected between said pre-tensioned drive mechanism and said plunger rod.

Abstract: A feedback element for a medicament delivery device, wherein the feedback element comprises two outer longitudinally extending flexible legs (21b) having a proximal and a distal end, and two inner longitudinally extending legs (19) having a proximal and a distal end; wherein the two inner longitudinally extending legs (19) are connected at their proximal ends by a proximal transversal end portion (21d) defining a guide extension and wherein each outer longitudinally extending flexible leg (21b) is connected to one inner longitudinally extending leg (19) by a distal transversal end portion (21a) and wherein each outer longitudinally extending flexible leg (21b) extends at its proximal end radially outwards defining a radial foot 21c.

Abstract: A drug delivery device comprising; a housing; a cylindrical member configured to be rotatably supported inside the housing, wherein the outer surface of the cylindrical member is provided with at least first and second tracks together forming an encoder, each track comprising conductive segments and non-conductive segments; and at least first and second groups of contacts configured to engage the first and second tracks respectively at predetermined intervals along the length of the track.

Abstract: An injection device having a delivery element with an inner thread may be driven by rotation and includes a cylindrical outer wall region, which is substantially smooth. Such features provide a delivery element configured such that it is less intimidating to patients than known threaded rods, and may facilitate easy cleaning. The delivery element may be non-rotatably guided and axially spring-loaded, and may be inserted axially into the housing when the reservoir is replaced. The driving thread element for the delivery element may be mounted in the vicinity of the distal end of the housing.

Abstract: A medicament dispensing mechanism is disclosed that is configured to eject successive doses of the medicament from a medicament chamber. An embodiment of the dispensing mechanism includes a housing and a plunger rod configured for ejecting the doses of medicament from the chamber. The dispensing mechanism further includes an actuation mechanism that comprises a trigger associated with the housing and having a ready and a fired position with respect thereto. The trigger is configured for manipulation by a user for successive movement in a generally axial dosing motion from the ready position to the fired position in which the trigger is associated with the plunger rod to cause the plunger rod to eject one of the doses of a predetermined volume and a resetting motion from the fired position to the ready position that comprises axial rotation, wherein the trigger is uncoupled from the plunger rod during the resetting motion.

Abstract: The present invention relates to a combined cartridge and needle assembly (10, 15) for use in a re-useable injection device The cartridge (10) containing a pharmaceutical liquid drug and the needle assembly (15) with a needle cannula (25) is permanently attached to each other to form one single unit mountable in the re-usable injection device. The needle assembly (15) is preferably also provided with a spring operated telescopic shield (20) which carries a reservoir (40) containing a cleaning solvent for cleaning at least the distal tip (27) of the needle cannula (25) between injections.

Abstract: The present disclosure relates to a cap assembly (5) for a medicament delivery device, comprising: a cap (7) having a tubular body (7b) defining an axially extending distal opening (7c) and configured to be mounted to a proximal end of a medicament delivery device, wherein the cap (7) has a bottom structure (7e) defining a proximal end of the distal opening (7c), wherein the bottom structure (7e) has a cam structure (7f) provided inside the tubular body (7b), and wherein the tubular body (7b) has inner walls provided with radial recesses (7d), and an elongated squeeze member (9) configured to be received in the distal opening (7c) of the tubular body (7b), and having a longitudinally extending channel (9d) configured to receive a delivery member shield, and which squeeze member (9) has radial arms (9e) flexible in the radial direction and forming part of a wall of the channel (9d), wherein the squeeze member (9) has a proximal end face (9a) configured to cooperate with the cam structure (7f) of the cap (7), w

Abstract: A needle assembly includes a needle hole having an inside diameter that is greater than an outside diameter of a needle, and by a moving-side guide integrally provided to a needle tip cover being engaged with a fixed-side guide fixedly provided to the needle, a guide mechanism is provided to guide the needle tip cover from a proximal end side towards a distal end side of the needle while maintaining a state of noncontact with the needle, and to guide the needle tip cover to a position where the needle tip cover covers the needle tip while deviating the needle tip cover in a direction in which the needle hole goes away from a center axis of the needle at a position beyond the needle tip, and avoiding contact of the needle tip with the needle hole.

Abstract: A medical injector includes an injector housing defining a reservoir, a plunger rod, and a stopper engaged with a portion of the plunger rod, the stopper being slidably disposed within the reservoir and sized relative to an interior of the injector housing to provide sealing engagement with a sidewall of the injector housing. The medical injector further includes a needle having a sharpened first end and a second end in communication with the reservoir, a first cap covering the sharpened first end of the needle, and a second cap covering at least a part of the first cap. The second cap includes a body having a proximal end, a distal end, and a hemispherical member including a gripping component. The second cap is engaged with the first cap such that removal of the second cap simultaneously removes the first cap from the first end of the needle.

Abstract: One embodiment is directed to a system for injecting, comprising a syringe body defining an interior medicine chamber; a stopper member configured to be inserted into the interior medicine chamber to contain medicine within the medicine chamber; a plunger member configured to be manually manipulated to insert the stopper member relative to the syringe body; a needle having proximal and distal ends, the proximal end comprising an anchoring geometry configured to be at least partially penetrated into the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper to be at least partially contained within the interior medicine chamber; and an energy-storing member operatively coupled between the stopper member and the syringe body, the energy-storing member configured to facilitate retraction of the stopper member relative to the syringe body.

Abstract: A safety assembly for a medicament delivery device is presented that prevents premature activation or firing of the device during shipping or handling. The disclosed safety assembly uses a tubular cover partially contained inside of the housing of the delivery device that is axially slidable relative to the housing from a first position to a second position and then to a third position, the tubular cover having a housing nib and a cap nib, where each of the cap nib and housing nib protrudes radially outward from an outer surface of the tubular cover and are located at a proximal end of the tubular cover. In the first position the housing nib and cap nib are located outside of the housing with the housing nib abutting the terminal proximal face of the housing to prevent axial movement of tubular cover relative the housing.

Abstract: A pump cassette body for detecting air bubbles in a fluid pathway, comprises an upstanding flow director vane, a fitment integrally molded into the pump cassette body, wherein the fitment comprises a base integrally molded into the pump cassette body, an elastomeric member attached to the base, and a housing at least partially surrounding the elastomeric member, wherein the elastomeric member is co-molded to the housing.

Abstract: A syringe assembly configured to urge soft tissue out of a surgical path includes a syringe, an elongate support member and a securing member. The syringe includes a barrel, a needle with a needle tip and a plunger movably mounted in the syringe barrel. The syringe defines a longitudinal axis. The elongated support member has a proximal end, a distal end and an arcuate-shaped cross-section. The securing member is fixed near the proximal end of the elongate support member. The securing member is configured to attach the elongate support member to the syringe. A support length is defined between the securing member and the distal end and a tip length is defined between the securing member and the needle tip when the support member is mounted to the syringe. The tip length is greater than the support length when the syringe assembly is in an injection configuration.

Abstract: Systems, methods, and devices can detect a dangerous or adverse condition or anticipated condition that indicates an undesirable amount of electric current in a patient-connected tube providing fluid to a patient. The fluid flow to the patient is stopped responsive to the detection. Stoppage of fluid flow to the patient can reduce or prevent electric current in the fluid from reaching a patient, flowing through the patient to ground, and/or continuing to flow through the patient.

Abstract: A medical spraying device and method for irrigating a wound, in particular lavage system, having a liquid reservoir for a medical irrigation liquid or a connection for such a liquid reservoir, and a compressed gas reservoir. The compressed gas reservoir is connected or connectable via a pressure line to the liquid reservoir, such that the irrigation liquid can be pushed by the gas pressure of the compressed gas reservoir acting on the irrigation liquid through a nozzle in order to produce a spray cone. A pressure reduction valve is arranged in the pressure line and limits the gas pressure acting in the liquid reservoir on the irrigation liquid. The device and method produce a spray cone of a medical irrigation liquid in which a gas pressure is limited using a pressure reduction valve, wherein the gas pressure limited by the pressure reduction valve is conveyed through a pressure line to a liquid reservoir of the medical irrigation liquid.

Abstract: Disclosed are methods, apparatus, and systems useful for detecting leaks in pleural tissue. Also disclosed are methods of detecting and sealing such leaks. Indicator dye or stain is aerosolized and delivered to the lung via anesthetic equipment, oxygen tube, endoscope, or other suitable equipment, the dye is allowed to travel through the lung along the path or paths of least resistance emerging at the surface of the lung, staining the tissue indicative of a leak. Some embodiments include introducing one part of a two part sealant with the dye, and applying the second part of the sealant to the stain identified leak locations.

Abstract: A system and method for communicating data from a medical device to a lighting device is provided. The system may include the medical device, the lighting device, and/or one or more interface devices. The medical device may be configured to transmit data to the lighting device, which for example, may include information relating to the medical device, dosage information, diagnostic data, medical device training feedback, health monitoring information, and/or air quality information. The lighting device may be configured to receive data from the medical device and control one or more lighting characteristics based on the received data. A characteristic of the light may include one or more of color, color temperature, intensity, flashing or steady-state, on or off, and/or the like. The system may provide for a home based adherence and/or compliance monitoring system, in which a patient's interaction with a medical device may be monitored and an alert/indication provided.

Abstract: A personal vapor inhaling unit is disclosed. An electronic flameless vapor inhaler unit that may simulate a cigarette has a cavity that receives a cartridge in the distal end of the inhaler unit. The cartridge brings a substance to be vaporized in contact with a wick. When the unit is activated, and the user provides suction, the substance to be vaporized is drawn out of the cartridge, through the wick, and is atomized by the wick into a cavity containing a heating element. The heating element vaporizes the atomized substance. The vapors then continue to be pulled by the user through a mouthpiece and mouthpiece cover where they may be inhaled.

Abstract: A portable rescue inhaler having a first canister containing a gas mixture of helium, oxygen, and nitrogen, and having a second canister containing an aerosolized medicine. The gas mixture of helium, oxygen, and nitrogen contained in the first canister has a density slightly lower than the density of atmospheric air. The portable rescue inhaler is capable of delivering the lower density gas mixture simultaneously with the aerosolized medicine for emergency hand held rescue of patients suffering from asthma, asthmatic bronchitis, COPD, emphysema, cystic fibrosis, and myocardial insufficiency. The portable rescue inhaler is capable of providing a vaporized anesthetic for greater medical assistance for patients in need of anesthesia due to respiratory insufficiency. The portable rescue inhaler reduces intra-operative risks in respiratory patients prior to gaining access to a hospital or care center.

Abstract: Some embodiments are directed to a device for monitoring patient usage of a medicament inhaler, being adapted to deliver doses of medicament, and including parts which move during the dispensing of a dose of medicament. The device includes a housing, for releasable attachment to the medicament inhaler, and an optical dose counter associated with said housing, being adapted to determine when a dose of medicament has been dispensed by transmitting optical signals through the medicament inhaler. The device is attachable to the medicament inhaler, and is subsequently operable without any modifications being required to be made to the medicament inhaler. The device may also include an electronic control module which is in communication with the optical dose counter, the electronic control module being adapted to monitor and/or store data relating to patient usage of the medicament inhaler.

Abstract: A thermally modulating inhalable medicament delivery device may deliver an inhalable medicament as an aerosol, vapor, or partial aerosol and partial vapor mixture. The inhalable medicament may be delivered to a target in a subject. Described herein are devices, systems, and methods for delivering an inhalable medicament to a subject.

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

Abstract: Systems and/or methods for assessing the sleep quality of a patient in a sleep session are provided. Data is collected from the patient and/or physician including, for example, sleep session data in the form of one or more physiological parameters of the patient indicative of the patient's sleep quality during the sleep session, a subjective evaluation of sleep quality, etc.; patient profile data; etc. A sleep quality index algorithm, which optionally may be an adaptive algorithm, is applied, taking into account some or all of the collected data. Sleep quality data may be presented to at least the patient, and it may be displayed in any suitable format (e.g., a format useful for the patient to be appraised on the progress of the treatment, a format useful for a sleep clinician to monitor progress and/or assess the effectiveness of differing treatment regimens, etc).

Abstract: A blower assembly is configured to deliver a flow of breathable gas at a continuously positive pressure with respect to ambient air pressure to a patient interface in communication with an entrance to a patient's airways including at least an entrance of the patient's nares, while the patient is sleeping, to ameliorate sleep disordered breathing. The blower assembly includes a motor having a shaft that extends from opposite sides of the motor. The blower assembly also includes an impeller and a circuit board. The impeller is attached to the shaft on a first side of the motor and is structured to rotate in close proximity to a volute wall. The circuit board is configured to control power supplied to the motor and is configured to disable the motor when the impeller is closer than a predetermined distance from the volute wall.

Abstract: A ventilator device delivers ventilatory support to a patient in a back up timed mode when patient respiration is not detected or a spontaneous mode when patient respiration is detected. The timing threshold governing the back-up mode is chosen to deviate from normal expected respiration time for the patient to promote patient initiated ventilation in the spontaneous mode but permit back-up ventilation in the event of apnea. Automated adjustments to the timing threshold during the timed mode are made from the less vigilant timing threshold to a more vigilant threshold at or near a timing of normal expected breathing of the patient. Such adjustments may be made from a minimum to a maximum vigilance timing settings or incrementally there between as a function of time in the timed mode which is preferably the number of delivered machine breaths.

Abstract: To solve the problem of providing a tracheostoma plaster that has a good sealing effect in the area of skin directly bordering a tracheostoma, a tracheostoma plaster (10) is proposed, having a proximal and a distal side (12, 14), having an adhesive strip (16) arranged on the distal side, having a receptacle (36) for a tracheostoma aid and having an annular bead (20), which is arranged on the proximal side of the plaster on a portion of the same, wherein the receptacle is surrounded by the annular bead.

Abstract: According to a preferred embodiment of the present invention there is provided a bite block assembly adapted for capnography and oxygen delivery to a subject, the bite block assembly (50) including a first capnography passageway adapted for passage therethrough of exhaled breath from the subject to a capnograph and a second oxygen delivery passageway, separate from the first passageway, adapted for passage therethrough of oxygen from an oxygen source to the mouth of the subject.

Abstract: A mask system for providing pressurized breathable gas includes at least one panel and a seal member, wherein the panel comprises a textile. The panel defines a cavity adapted to receive a patient's nose. The seal member is adapted to sealingly engage with the patient's face. The panel and seal member may be integrally formed in one piece.

Abstract: Devices for providing respiratory therapy to a patient are disclosed. One device includes first and second elongated lumens and a nosepiece. The elongated lumens each have a constant internal diameter. The nosepiece portion has a third lumen and a fourth lumen. The third and fourth lumens have constant internal diameters equal to those of the first and second lumens. The third and fourth lumens have inlet ends adapted to be connected to the outlet ends of the first and second lumens without constricting the internal diameter of the first and second lumens. The third and fourth lumens are configured to receive first and second flows of breathing gas from the first and second lumens and deliver the flows of breathing gas to outlets end of the third and fourth lumens. The second flow of breathing gas is maintained separate from the first flow of breathing gas within the nosepiece portion.

Abstract: A medical carbon monoxide generator provides for a solid carbon material that may be heated at substantially normal atmospheric pressure to provide a source of medical quality carbon monoxide. The heating source may be an electrical filament or laser controllable by a microcontroller to provide accurate delivery rates and amounts. In one embodiment, a replaceable cartridge holding the carbon material may be used.

Abstract: A CPAP apparatus is configured to deliver a flow of pressurized, humidified breathable gas to a patient's airways. The CPAP apparatus includes a blower, a humidification unit and a dehumidification unit. The blower is configured to generate a flow of breathable gas pressurized within a predetermined pressure range. The humidification unit is configured to humidify the pressurized breathable gas discharged from the blower. The dehumidification unit is configured to draw condensation from ambient air and operate at the same time as the humidification unit. An air outlet of the CPAP apparatus is sealingly attachable to an air delivery tube and patient interface assembly.

Abstract: The invention provides a device (11) for assisting a cough, based on an oscillation pressure. The oscillation pressure causes a periodic oscillation airflow in a lung system and the periodic oscillation airflow comprises an oscillation exhalation airflow and an oscillation inhalation airflow. The device (10) comprises a controlling unit (11), and the controlling unit (11) comprises: a first determining unit (111) for determining whether an inhalation of the lung system is complete, so as to control a valve (13) which is to be closed for isolating the lung system from the external environment, a second determining unit (112) for determining whether an internal air pressure in the lung system is larger than a pre-defined pressure threshold, and a detecting unit (113) for detecting the start of the oscillation exhalation airflow, so as to control the valve (13) which is to be opened for starting a cough.

Abstract: A method for communicating with devices may include monitoring brain activity of a subject via an EEG monitoring system coupled to the subject. The method also may include detecting a predefined state of brain activity of the subject. Further, based on the detecting the predefined state, the method may include wirelessly transmitting instructions from the EEG monitoring system to the at least one household device to adjust a setting of the at least one household device.

Abstract: A method and an apparatus for controlling a temperature adjustment device using a sensing device are provided. The method includes setting a test temperature, transmitting a temperature adjustment instruction corresponding to the test temperature to a temperature adjustment device, calculating a sleep score based on bio information received from the sensor, when applying the test temperature, and determining a sleep optimal temperature based on the calculated sleep score.

Abstract: The present invention relates to a device and method of training a child to go to sleep by providing a light which dims in response to a child sound or a presence other than the child and turns back on or brightens when the sound stops or the presence leaves.

Abstract: A catheter apparatus includes a replaceable module, a main body portion and a sensing module. The main body portion includes a tube, a urine guide opening and an elastic unit. The replaceable module includes a control unit. A first terminal of the tube is coupled to the replaceable module and a second terminal of the tube is inserted into the bladder. The urine guide opening is disposed at the second terminal of the tube and used to guide urine into the tube when the second terminal of the tube is inserted into the bladder. The elastic unit is disposed at the second terminal of the tube and coupled to the control unit. The sensing module is coupled to the control unit and used to sense whether the second terminal of the tube is inserted to the correct position in the bladder and transmit sensing result to the control unit.

Abstract: The invention is a catheter, which is formed from flexible material and has two basic configurations: An initial configuration, in which the catheter is supplied to the surgeon for insertion into the lumen of a patient, resembles a tension coil spring and a final configuration, which is an essentially linear configuration that is much longer and has a considerably smaller outer diameter than when it is in its initial configuration. The catheter is adapted to undergo a transformation from the initial configuration to the final configuration as it is pulled from its proximal end in order to withdraw it from the lumen of the patient.

Abstract: The present application relates to applicators and methods for administering therapeutic agents to cancerous tissue. The applicators can be used to deliver radiation and additional therapeutic agents to cancerous tissue located in a subject.

Abstract: A method and system for placing a device enabled for endovascular navigation, specifically a PICC catheter, and more broadly any device which is manipulated in over the wire or monorail fashion. Variants of the system comprise a guidewire for navigating through a patient's vasculature, having an electromagnetic (EM) based tracking components at or near the a leading end of the guidewire; an EM positioning field generator configured on a reference gantry; a computer and display configured to output position information of the guidewire leading end; and a servomotor delivery system actuator, mechanically coupled to the guidewire and configured for controlling the position of the guidewire.

Abstract: An apparatus includes a catheter, an introducer, and an actuator. A distal end portion of the introducer is configured to be coupled to a peripheral intravenous line. The introducer defines an inner volume having a first portion that defines an axis parallel to and offset from an axis defined by a second portion. A first portion of the actuator is movably disposed in the first portion of the inner volume. A second portion of the actuator is movably disposed in the second portion of the inner volume and coupled to the catheter movably disposed in the second portion of the inner volume. The actuator moves the catheter between a first position, in which the catheter is disposed within the introducer, and a second position, in which at least a portion of the catheter is disposed within the peripheral intravenous line.

Abstract: The invention is directed towards a retaining device for retaining at least one medical line. The retaining device includes a flexible body having a top and bottom surface with at least one slot formed in the top surface. The at least one slot extends to a depth greater than the largest medical line the retaining device is destined to be used with. An attachment mechanism is coupled to the flexible body for securing the flexible body to a supportive surface.

Abstract: A guidewire for backloading and inserting a percutaneous pump affixed to a cannula includes a proximal section made of a first material, with a first diameter, a rounded proximal end, and a distal end. The guidewire also includes a distal section made of a second material, with a second diameter which is greater than the first diameter, a distal end, and a proximal end abutting the distal end of the proximal section. The first material of the proximal section is selected to be softer than a material of the percutaneous pump to reduce damage to the pump during backloading. The distal section of the guidewire is configured to be stiffer than the proximal section to insert the percutaneous pump in a desired location without damaging the guidewire.

Abstract: A device for treatment of varicose veins includes a catheter (1), which can be inserted into a vein to be treated. There is a balloon (2) with at least one cutting element (3) for cutting at least part of an inner wall of the vein arranged on a proximal end (1a) of the catheter. The catheter has side openings (7a-7c), through which a sclerosing agent can be introduced into the vein. The at least one cutting element includes a cutting edge configured to cut intima and media of the vein when withdrawing the balloon from the vein after treatment with the sclerosing agent.

Abstract: Drug delivery devices and methods are disclosed herein. In some embodiments, a drug can be delivered into a brain ventricle of a subject, where it can diffuse, flow, or otherwise travel across the ependyma and into the hippocampus. The drug can be delivered through a delivery device configured to selectively or transiently obstruct a portion of the ventricle, e.g., the temporal horn or a posterior portion of the temporal horn. The obstruction can define a partitioned volume of the ventricle, limiting or preventing flow of cerebrospinal fluid (CSF) into or out of the partitioned volume. Accordingly, a drug can be delivered into the partitioned volume without being diluted or carried away by CSF, allowing the drug to saturate the ependyma adjacent the hippocampus.