Abstract: Certain embodiments of the disclosure relate to targeted binding agents that specifically bind to JAM-like protein and therein inhibit epithelial damage. Although it is not intended that embodiments of the disclosure be limited by any particular mechanism, it is believed that a possible mechanism by which this can be achieved may include, but are not limited to, either inhibition of binding of JAML to the CAR, inhibition of JAML induced CAR signaling, or increased clearance of JAML from the body of a subject, therein reducing the effective concentration of soluble JAML. In certain embodiment, the specific binding agent is a fully human antibody or chimera that specifically binds to human JAML, such as the JAML D1, and prevents JAML binding to CAR. Certain embodiments of the disclosure contemplate antibodies comprising human IgG type, e.g., IgG1, IgG2, IgG3, and IgG4.

Abstract: Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

Abstract: The present disclosure relates to one or more agents, therapies, treatments, and methods of use of the agents and/or therapies and/or treatments for decreasing production and/or functionality of one or more immune checkpoint molecules.

Abstract: The present invention is directed to bispecific molecules (e.g., diabodies, bispecific antibodies, trivalent binding molecules, etc.) that possess at least one epitope-binding site that is immunospecific for an epitope of PD-1 and at least one epitope-binding site that is immunospecific for an epitope of CTLA-4 (i.e., a “PD-1×CTLA-4 bispecific molecule”). The PD-1×CTLA-4 bispecific molecules of the present invention are capable of simultaneously binding to PD-1 and to CTLA-4, particularly as such molecules are arrayed on the surfaces of human cells. The invention is directed to pharmaceutical compositions that contain such PD-1×CTLA-4 bispecific molecules, and to methods involving the use of such bispecific molecules in the treatment of cancer and other diseases and conditions. The present invention also pertains to methods of using such PD-1×CTLA-4 bispecific molecules to stimulate an immune response.

Abstract: A combination therapy comprising a MEK inhibitor, a PD-1 axis inhibitor, and a VEGF inhibitor is provided for the treatment of colorectal cancer and metastatic colorectal cancer.

Abstract: The present invention provides an isolated monoclonal antibody or an antigen-binding portion thereof which a) binds to Mac-1, b) specifically inhibits the interaction of CD40L with activated Mac-1 and c) does not induce integrin outside-in signaling.

Abstract: The present invention provides antibodies that bind specifically to TrkB and methods of using the same. According to certain embodiments, the antibodies of the invention are agonist antibodies that are neuroprotective, as shown by their effect on enhancing the survival of retinal ganglion cells in vitro. As such, these agonist antibodies may be used to treat diseases or disorders of the eye, such as, but not limited to glaucoma. In addition, other neuronal diseases or disorders may benefit from treatment with these agonist antibodies, including any disease or disorder characterized in part by neuronal damage. In certain embodiments, the invention includes antibodies that bind TrkB and mediate cell signaling. The antibodies of the invention may be fully human, non-naturally occurring antibodies.

Abstract: This invention provides antibodies that recognize the B Cell Maturation Antigen (BCMA) and that bind naïve B cells, plasma cells, and/or memory B cells. The invention further provides methods for depleting naïve B cells, plasma cells, and memory B cells, and for treating B cell-related disorders, including lymphomas and autoimmune diseases.

Abstract: Provided herein are chimeric receptors, such as chimeric antigen receptors (CARs), comprising BCMA-binding molecules, such as anti-BCMA antibodies and antigen-binding fragments thereof, such as heavy chain variable (VH) regions and single-chain antibody fragments, and encoding polynucleotides. In some embodiments, the anti-BCMA chimeric receptors specifically bind to BCMA. Among the anti-BCMA-binding molecules are human antibodies, including those that compete for binding to BCMA with reference antibodies, such as a non-human reference antibody. Also provided are genetically engineered cells expressing the CARs and uses thereof such as in adoptive cell therapy.

Abstract: There is disclosed compositions and methods relating to or derived from anti-CD137 antibodies. More specifically, there is disclosed fully human antibodies that bind CD137, CD137-antibody binding fragments and derivatives of such antibodies, and CD137-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease requiring either stimulation of immune responses or suppression. Diseases amenable to treatment is selected from the group consisting of cancers, autoimmune diseases and viral infections.

Abstract: The invention provides bispecific polypeptides comprising a first binding domain, designated B1, which is capable of binding specifically to OX40, and a second binding domain, designated B2, which is capable of specifically binding to a tumour cell-associated antigen. Also provided are pharmaceutical compositions of such bispecific polypeptides and uses of the same in medicine.

Abstract: The disclosure provides constructs comprising a first fusion protein, a second fusion protein, and a linker, wherein the first fusion protein and the second fusion protein each include an affinity reagent and a reactive enzyme, and the linker includes a first and second functional groups specific for irreversibly inhibiting the first and second fusion protein reactive enzymes. The disclosure further provides a method including (a) contacting a first fusion protein including an affinity reagent and a reactive enzyme with a linker including a functional group specific for irreversibly inhibiting the first fusion protein reactive enzyme thereby coupling the first fusion protein and the linker, and (b) contacting a second fusion protein including an affinity reagent and a reactive enzyme with the linker, the linker including a functional group specific for irreversibly inhibiting the second fusion protein reactive enzyme thereby coupling the second fusion protein and the linker.

Abstract: A cellulose ester, wherein, in a structural formula of the following general formula (I), a degree of substitution where X is an acyl group is from 2.91 to 3.0; the acyl group includes benzoyl group (A) optionally having a substituent, and benzoyl group (B) optionally having a substituent different from that of benzoyl group (A); and when the degree of substitution is 3.0, a degree of substitution of benzoyl group (A) is from 1.5 to 2.9, and a degree of substitution of benzoyl group (B) is from 0.1 to 1.5, wherein all or some of X represents an acyl group; when some of X represents an acyl group, the remainder represents a group selected from a hydrogen atom and an alkyl group; and n represents an integer of from 20 to 20,000.

Abstract: A process for the manufacture of an acylated polymer composition including amylose and/or amylopectin, including a pre-treatment step in the presence of an acid and a hydroxycarboxylic acid, subsequent acylation and, preferably, a post-treatment step with an acid. The products obtained are useful as additives in inks, varnishes, lacquers, coatings, thickeners, adhesives or binders.

Abstract: Catalyst systems including more than one metallocene catalysts and processes for using the same are provided to produce polyolefin polymers such as polyethylene polymers.

Abstract: The present disclosure relates to asymmetric ansa-metallocene catalyst compounds that include at least one indenyl ligand substituted at the 3-position with a C3-C40 ?-branched alkyl, such as 1-methylethyl, 1-methylpropyl, 1-methylbutyl, 1-ethylbutyl, 1,3-dimethylbutyl, 1-methyl-1-ethylbutyl, 1,1-diethylbutyl, 1-propylpentyl, and the like. Catalyst systems prepared with the catalyst compounds, polymerization methods using such catalyst systems, and polyolefins made using the polymerization methods are also described.

Abstract: The present disclosure relates to ansa-metallocene catalyst compounds that include (1) a first indenyl ligand substituted at the 3-position with a substituted or unsubstituted C4-C40 hydrocarbyl group, wherein the hydrocarbyl group is branched at the ?-position, and (2) a second indenyl ligand substituted at its 3-position with a substituted or unsubstituted alkyl group or a ?-branched alkyl group. Catalyst systems prepared with the catalyst compounds, polymerization methods using such catalyst systems, and polyolefins made using the polymerization methods are also described.

Abstract: Techniques regarding a star polymer with light-activated enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a plurality of non-degradable copolymer arms comprising respective first ends and respective second ends. The respective first ends can be crosslinked to form a vinyl polymer core and the respective second ends can have antimicrobial functionality. Further, the polymer can comprise a singlet oxygen generator loaded within the vinyl polymer core. The singlet oxygen generator can generate a singlet oxygen species in response to light.

Abstract: The present invention provides a protein aggregation inhibitor for use in preventing aggregation of a protein, which contains a terminal sulfanyl group-containing sulfobetaine polymer having a repeat unit derived from a sulfobetaine monomer represented by the formula (II), and a noble metal particle, and in which the terminal sulfanyl group-containing sulfobetaine polymer is chemisorbed on the noble metal particle by the sulfanyl group (the groups in the following formula are as defined in the DESCRIPTION).

Abstract: Disclosed herein is a polyethylene. The polyethylene has a melt flow index of about 0.4 g/10 min to about 0.6 g/10 min, a weight average molecular weight of about 500,000 g/mol to about 700,000 g/mol, and a molecular weight distribution of about 3 to about 5 and is prepared by polymerization in the presence of a catalyst retaining at least about 50% of an initial reactivity level (during initial 30 minutes) for a period of time exceeding about 4 hours.

Abstract: The invention covers a supported catalyst system prepared according to a process comprising the following step: i). impregnating a silica-containing catalyst support having a specific surface area of from 150 m2/g to 800 m2/g, preferably 280 m2/g to 600 m2/g, with one or more titanium compounds of the general formula selected from RnTi(OR?)m and (RO)nTi(OR?)m, wherein R and R? are the same or different and are selected from hydrocarbyl groups containing from 1 to 12 carbon and halogens, and wherein n is 0 to 4, m is 0 to 4 and m+n equals 4, to form a titanated silica-containing catalyst support having a Ti content of at least 0.1 wt % based on the weight of the Ti-impregnated catalyst support wherein the supported catalyst system further comprises an alumoxane and a metallocene.

Abstract: This invention relates to processes for forming hydrogen mediated saline hydride initiated anionic polymer distributions via novel polymerization conditions in which molecular hydrogen is a chain transfer agent and a Lithium Aminoalkoxide Complexed Saline Hydride (LOXSH) forms an anionic polymer chain initiating species by addition of saline hydride to an anionically polymerizable hydrocarbon monomer. This invention further relates to polystyrene compositions having greatly improved microstructures free of co-product polymer chain distributions. This invention also relates to novel hydrocarbon soluble saline hydride catalyst and reagent compositions useful in conducting the hydrogen mediated saline hydride initiated polymerizations of this invention. This invention further relates to hydrocarbon soluble lithium hydride catalysts and reagent compositions formed from dimethylaminoethanol, an alkyllithium reagent and molecular hydrogen.

Abstract: Polyethylene compositions including at least 65 wt % ethylene derived units, based upon the total weight of the polyethylene composition, are provided. Films made from these polyethylene compositions are also provided as well as processes for making the same.

Abstract: Disclosed herein are methods of controlling polymer properties in polymerization processes that use a chromium-based catalyst. An embodiment discloses a method of producing a polyolefin comprising: contacting a reaction mixture and a reduced chromium oxide catalyst in a gas-phase reactor to produce the polyolefin, wherein the reaction mixture comprises a monomer and a co-monomer; and changing a reaction temperature in the gas-phase reactor by about 1° C. or more whereby a gas molar ratio of the co-monomer to the monomer is changed by about 2% or more and a co-monomer content of the polyolefin at substantially constant density is changed by about 2% or more. Additional methods and compositions are also provided.

Abstract: Embodiments of the invention described herein relate to a polyethylene polymer composition suitable for use in the manufacture of packaging articles, flexible films and/or sheets. In one embodiment, the copolymer comprises a polyethylene resin with density 0.918 g/cm3 to about 0.935 g/cm3, G? at G?(500 Pa) value, as determined from Dynamic Mechanical Analysis at 190° C., of less than 40 Pa, Mz/Mw of greater than 2, CDBI50 of greater than 60. Other embodiments relate to polymer compositions with defined molecular characteristics and formulations suitable for use in the manufacture of articles including films, sheets, bags and pouches with improved creep resistance and high toughness and a good balance of film stiffness and processability in monolayer and/or multi-layer film structures.

Abstract: The present invention relates to a composition comprises at least one random copolymer having at least one repeat unit of structure (1), The present invention also relates to novel processes for forming patterns using this novel crosslinked layer on a substrate by enable a film of a block copolymer coated on the novel crosslinked layer to undergo self-assembly.

Abstract: An object of the present disclosure is to provide a terminal-modified conjugated diene polymer having a high cis-1,4 content and a low molecular weight distribution value and being excellent in durability (such as wear resistance, fracture resistance, cracking resistance, and the like). In order to achieve the object, a terminal-modified conjugated diene polymer of the present disclosure characteristically has: molecular weight distribution determined by gel permeation chromatography (GPC) of less than 2; and content of cis-1,4 bond of 95% or more.

Abstract: Disclosed is a polyoxymethylene resin composition that includes a filler in an amount of about 5 to 30 wt %, a formaldehyde reducing agent in an amount of about 0.01 to 1 wt %, and a polyoxymethylene resin constituting the remaining balance of the polyoxymethylene resin composition, all the wt % based on the total weight of the polyoxymethylene resin composition. In particular, per 1 g of the polyoxymethylene resin may include an amount of 30 to 40 ?mol of formate at terminal ends of the polyoxymethylene resin.

Abstract: Provided is a photo-curable composition capable of creating a three-dimensional object excellent in both of: stiffness and strength; and toughness. Specifically, provided is a photo-curable composition including: a blocked isocyanate represented by the general formula (1); a chain extender; and a photo-radical generator: in the general formula (1), A1 to A4 each independently represent a structure represented by the following general formula (2), and B represents a structure represented by the following general formula (3).

Abstract: The present invention relates to a polyester resin comprising a biomass-derived monomer and a preparation method therefor, and a powder paint composition comprising the resin and, more specifically, to a polyester resin and a preparation method therefor, and a powder paint composition comprising the resin, wherein the polyester resin comprises, as a repeat unit, a biomass-derived unit having improved reactivity and being derived from an anhydrosugar alcohol or a derivative thereof, thereby solving the problem of the depletion of petroleum resources corresponding to limited resources, exhibiting eco-friendliness and high-heat resistance, and remarkably improving weather resistance and flexibility of a coating film when used for a powder paint.

Abstract: Embodiments of the present invention are concerned with a method for producing a binder resin composition, from which a toner having excellent low-temperature fusing property, heat-resistant storage stability, durability, and image density is obtained, a binder resin composition, and a toner for development of electrostatic images including the binder resin composition. Embodiments according to the present invention are concerned with the following [1] to [3].

Abstract: The invention relates to compositions comprising polycarbonate and to a mixture comprising a carboxylic acid and the glycerol and/or diglycerol esters thereof, to the use of the compositions for production of blends or mouldings and to mouldings obtainable therefrom. The compositions have improved rheological and optical properties.

Abstract: The invention relates to a two-stage method for the preparation of polyoxyalkylene polyols having low equivalent molar masses, in which the method requires no reprocessing. The invention is characterized in that, in the first stage, a polyoxyalkylene polyol precursor is provided, which contains the salts of a strong Bronsted acid, and in that, in a second stage, the polyoxyalkylene polyol precursor is further reacted with alkylene oxides under DMC catalysis.

Abstract: Compositions including one or more polymers are provided. Exemplary polymers include polymeric carbon monoxides. The compositions can be prepared by subjecting a source material to x-rays, optionally at increased pressures. The compositions can be used in a variety of applications, such as fuels, optics, and electronics.

Abstract: The present invention relates to a hybrid nanodot made by a process comprising a step of reacting a mixture of an amino acid and a polymer selected from polycationic polymers or any copolymers or derivatives of these polymers under hydrothermal reaction conditions. The present invention also relates to a process for synthesizing said hybrid nanodots.

Abstract: Provided is a photosensitive resin composition containing; (A) a polymer having an acidic functional group or a substituent derived therefrom; (B) a photoreactive compound; (C) a solvent; and (D) a nitrogen-containing aromatic compound represented by the following general formula (1).

Abstract: A polyimide resin including a structural unit A derived from a tetracarboxylic dianhydride and a structural unit B derived from a diamine compound, wherein the structural unit A includes at least one of a structural unit (A-1) derived from a compound represented by the following formula (a-1), a structural unit (A-2) derived from a compound represented by the following formula (a-2), and a structural unit (A-3) derived from a compound represented by the following formula (a-3), the structural unit B comprises a structural unit (B-1) derived from a compound represented by the following formula (b-1), a proportion of the structural unit (B-1) in the structural unit B is 60 mol % or more, and the polyimide resin has a glass transition temperature of higher than 410° C.: wherein X and Y in the formula (b-1) each independently are a hydrogen atom, a methyl group, a chlorine atom, or a fluorine atom.

Abstract: A method for forming a polyarylene sulfide is described. The method can include a multi-step cooling and precipitation process in which the cooling rate of the solution that carries the polymer is decreased during a portion of the overall cooling. This slower cooling period can encompass at least a portion of the period during which the polymer precipitates from the solution. The precipitation process can form polyarylene sulfide particles with good particle integrity and a narrow particle size distribution, which can reduce fines and improve downstream processing and final product characteristics.

Abstract: The present invention provide a composition comprising: a polyacrylate-polysilane block copolymer of structure (I) and an organic polymer which is different from the block copolymer of formula (I) wherein m and n independent of one another, are integers ranging from 2 to 4000; p is an integer ranging from 0 to 5; q is an integer ranging from 1 to 5; R1 represents hydrogen, straight-chain or branched alkyl group having 1 to 4 carbon atoms; R2 represents hydrogen, straight-chain or branched alkyl group having 1 to 18 carbon atoms; R3 represents hydrogen, hydroxyl group, straight-chain or branched alkyl group having 1 to 4 carbon atoms, or an C6-C14-aryl group; L is a single bond or a bivalent group —NH—, —C(O)NH—, —NHC(O)NH—, —OC(O)NH— or —CH2—; R4, R5 and R6 independent of one another, represent hydrogen, straight-chain or branched alkyl group having 1 to 8 carbon atoms or a polydimethylsiloxane residue; and R7 represents hydrogen or methyl group.

Abstract: The invention relates a polyacrylate-polysilane block copolymer of general structure (I): wherein m and n independent of one another, are integers ranging from 2 to 4000; p is an integer ranging from 0 to 5; q is an integer ranging from 1 to 5; R1 represents hydrogen, straight-chain or branched alkyl group having 1 to 4 carbon atoms; R2 represents hydrogen, straight-chain or branched alkyl group having 1 to 18 carbon atoms; R3 represents hydrogen, hydroxyl group, straight-chain or branched alkyl group having 1 to 4 carbon atoms, or an C6-C14 aryl group; L is a linking moiety representing amine (—NH—) group, amide (—C(O)NH—) group, urea (—NHC(O)NH—) group, urethane (—OC(O)NH—) group or methylene (—CH2—) group; R4, R5 and R6 independent of one another, represents hydrogen, straight-chain or branched, alkyl group having 1 to 8 carbon atoms or polydimethylsiloxane group; and R7 represents hydrogen or methyl group.

Abstract: Provided is a photochromic curable composition which forms a cured body that develops excellent photochromic properties. The photochromic curable composition (A) includes: a polyrotaxane monomer wherein, in a polyrotaxane compound having a composite molecular structure composed of an axial molecule and a plurality of cyclic molecules threaded onto the axial molecule, and side chains having OH groups introduced into the cyclic molecules, 1 mol % or more to less than 100 mol % of OH groups in the side chains are modified with a compound having a radical-polymerizable group, (B) a photochromic compound, and (C) a polymerizable monomer other than the (A) polyrotaxane monomer.

Abstract: The present invention relates to a resin composition including an acrylic polymer (A) and a thermosetting resin (B), wherein a phase separation structure of a first phase containing the acrylic polymer (A) and a second phase containing the thermosetting resin (B) is formed, and an average domain size of the second phase is 20 ?m or less.

Abstract: Polyamide particles including polyamide and having a water absorption rate of 0.5 to 2.5 wt. % are prepared to improve toughness of a cured product of a curable resin. The polyamide may be a semicrystalline polyamide. The polyamide has a glass transition temperature of approximately 100 to 150° C. The polyamide may have an alicyclic structure. The polyamide particles of this invention have an average particle size of approximately 5 to 40 ?m and a specific surface area determined by the BET method of approximately 0.08 to 12 m2/g. The polyamide particles of the present invention may also be spherical and have an average particle size of approximately 15 to 25 ?m. Furthermore, the polyamide particles of the present invention may have an exothermic peak in a temperature range between the glass transition temperature and a melting point of the polyamide upon heating the polyamide particles at a rate of 10° C./min by differential scanning calorimetry (DSC).

Abstract: Lignocellulose composite products that include a hydrophobizing agent. The lignocellulose composite product can include a plurality of lignocellulose substrates, an at least partially cured binder composition, and a hydrophobizing agent. In one example, the hydrophobizing agent can include about 30 wt % to about 98 wt % of a fatty acid compound, about 0.1 wt % to about 15 wt % of a rosin acid compound, and about 1 wt % to about 40 wt % of an unsaponifiable compound. In another example, the hydrophobizing agent can include a tall oil pitch and a fatty acid composition.

Abstract: A heat-shrinkable polyester film is made from a polyester resin composition which includes an amorphous polyalkylene benzenedicarboxylate resin and a polyester elastomer resin. The polyester elastomer resin includes hard segments and soft segments, and is prepared by copolycondensation of an aromatic dicarboxylic acid and a diol component. The diol component includes a C2-C4 alkylene glycol for the hard segments and a polyethylene glycol with an average molecular weight not greater than 400 for the soft segments. The soft segments of the polyester elastomer resin are in an amount ranging from 1 part by weight to 2 parts by weight based on 100 parts by weight of the polyester resin composition.

Abstract: The present disclosure provides a polyolefin-based film including an olefin polymer which is controlled in the content of the branched polymer structure in the polymer and the weight average molecular weight of the main chain in the structure to exhibit excellent processability and transparency. Therefore, the polyolefin-based film not only exhibits high transparency independent of processing conditions, but also reduces the increase in film haze even when the thickness of the film increases.

Abstract: A method of making a foamed article, for example a foamed component for an article or footwear, comprises forming a structure of interconnected, unfoamed, thermoplastic polymeric members spaced to define openings between the thermoplastic polymeric members. The structure may be made by printing a thermoplastic polymeric material with a three-dimensional printer. The thermoplastic polymeric members are heated to a first temperature to soften the thermoplastic polymeric members and the softened thermoplastic polymeric members are infused with at least one inert gas at a first pressure greater than atmospheric pressure. The first pressure is sufficient to cause the at least one inert gas to permeate into the softened thermoplastic polymeric members. After being infused with the inert gas, the pressure is reduced to at least partially foam the thermoplastic polymeric members.

Abstract: A surface of a rubber sponge material 4 such as a vehicle weather strip is covered with a resin coat 6 containing dispersed cellulose fibers 5.

Abstract: A complex structure material includes a foam made of thermosetting resin and coverings made of thermoplastic resin. The foam includes a matrix and pores. At least some of the pores communicate with each other. The foam has a continuous porous structure formed by the matrix and the pores. The coverings cover inner walls of the pores in the foam.

Abstract: Methods of producing particles of fiber and resin from fiber-resin composite materials are disclosed. The particles may be combined with a resin system and optionally combined with fillers, binders or reinforcements to produce new cured solid composite products.