Abstract: Embodiments of the invention provide an in-situ polymerization technique for creating a glucose sensor chemistry stack. An analyte sensor comprises a crosslinked polymer matrix in contact with an electrode. The crosslinked polymer matrix is formed by exposing ultraviolet (UV) light to a polymer matrix mixture comprising a plurality of hydroxyethyl methacrylate (HEMA) monomers, one or more di-acrylate crosslinkers, one or more UV photoinitiators, and an oxidoreductase. The oxidoreductase is covalently linked to the crosslinked polymer matrix. In typical embodiments, the oxidoreductase is a glucose oxidase-acrylate bioconjugate. In one or more embodiments, the analyte sensor apparatus further comprises a glucose limiting membrane positioned over the crosslinked polymer matrix.

Abstract: A bioFET cell for measuring a time dependent characteristic of an analyte bearing fluid includes a source, a drain, a semiconductive single wall carbon nanotube network layer extending between the source and drain electrodes and electrically coupled there between, a gate insulatively spaced from and disposed over and extending between the source and drain electrodes, a layer of at least one selected antibody disposed on and linked to the polymer layer to functionalize the semiconductive single wall carbon nanotube network layer to a selected target biomarker corresponding to the at least one selected antibody so that electron transport into the semiconductive single wall carbon nanotube network layer is facilitated, where the source, drain and gate electrodes with the carbon nanotube network layer form a defined channel through which the analyte bearing fluid may flow, and a high impedance source follower amplifier coupled to the source electrode.

Abstract: Matrix materials such polymers derivatives to contain a redox active material can be used to form electrodes and probes suitable for use in pH meters and other analyte sensing devices.

Abstract: A method of determining a concentration of phenol and/or a phenol derivative in a first solution. The method includes (a) subjecting a graphite pencil electrode system comprising a graphite pencil working electrode, a counter electrode, and a reference electrode to cyclic voltammetry in a second solution such that a surface of the graphite pencil working electrode is charged by the cyclic voltammetry to form a charged surface, (b) contacting the charged surface of the graphite pencil working electrode with the first solution for sufficient time to electropolymerize the phenol and/or the phenol derivative on the charged surface in open circuit fashion, and (c) determining the concentration of the phenol and/or the phenol derivative in the first solution, wherein the amount of the electropolymerized phenol and/or the electropolymerized phenol derivative formed on the charged surface correlates with the concentration of the phenol and/or the phenol derivative in the first solution.

Abstract: System and method for characterizing material condition. The system includes a sensor, impedance instrument and processing unit to collect measurements and assess material properties. A model of the system may be used to enable accurate measurements of multiple material properties. A cylindrical model for an electromagnetic field sensor is disclosed for modeling substantially cylindrically symmetric material systems. Sensor designs and data processing approaches are provided to focus the sensitivity of the sensor to localize material conditions. Improved calibration methods are shown. Sizing algorithms are provided to estimate the size of defects such as cracks and corrosion. Corrective measures are provided where the actual material configuration differs from the data processing assumptions. Methods are provided for use of the system to characterize material condition, and detailed illustration is given for corrosion, stress, weld, heat treat, and mechanical damage assessment.

Abstract: A method of measuring a property of a medium using ultrasound, comprising: transmitting one or more ultrasound pulses into the medium from one or more transmitters and receiving at least a first echo signal and a second echo signal from within the medium at one or more receivers, wherein the first and second echo signals correspond to first and second pulse transmission paths within the medium from the one or more sources to the one or more receivers, the second path being different from the first path; and using the characteristics of the first and second echo signals together with an estimate of the property of the medium and a geometrical relationship between the first and second transmission paths to calculate a revised estimate of said property of the medium. By using two different beam paths within the medium, the first and second echoes will have had slightly different interactions with the medium.

Abstract: A method and apparatus are disclosed for assessment of a sealed package. Light is emitted from a narrow-band laser source towards said package from outside of said package. An absorption signal of said light scattered in said package is measured, wherein said absorption is caused by said at least one gas when said light is scattered and travels in said sealed package. Measuring is made outside of said package, whereby said assessment is non-intrusive with regard to said package. It is determined if a deviation exists from a predetermined, expected gas composition and/or concentration of said at least one gas within said sealed package based on said measured absorption signal. Thus sealing of said package for said gas is detected.

Abstract: An ultrasound diagnostic apparatus includes: a probe that includes a transducer array including transducers, which are activated as a first transducer group and a second transducer group, is configured to transmit ultrasound waves by at least one transducer included in the first transducer group and at least one transducer included in the second transducer group, and to detect echo signals from an object; and a controller configured to select a number of transducers to be activated in the first transducer group and in the second transducer group based on the object or a measurement result, generate echo images from the echo signals, and measure an object change movement speed, which is a speed at which a change in the object moves, from the echo images.

Abstract: A system is disclosed that increases the efficiency of a weld inspector by reducing the amount of weld data that needs to be examined for any non-destructive (“NDT”) phased array and time-of-flight, diffraction ultrasonic testing of welds. The system reads ultrasonic testing data from an NDT scan of a series of metal welds and creates a table of target weld indications ranked by a series of filters representative of predetermined exclusion and significance criteria. The invention acts as a weld analysis concentrator by focusing the attention of an inspector on potential weld flaws that merit their attention, thereby increasing the efficiency of the inspector. The process typically reduces 95% to 98% of the ultrasonic weld testing data that must be reviewed by the inspector, while retaining flaw indications necessary for an inspector's competent review in conformity with various code requirements and regulations.

Abstract: A method detects the presence of a vehicle on a railway track using a sensing processor monitoring a sensing system for detecting vibration into ground installed along the railway track. The sensing system includes a detection module for detecting a vehicle on the railway track. The method includes an initialization step which includes the sub-steps of emitting a first signal to be received by the sensing processor through the sensing system, sending a first message to the sensing processor, monitoring the sensing system, and configuring the detection module in function of the received first signal and configuration data received in the first message. The configuration data can include location of the initialization device, intensity/magnitude of the first signal, emission time of the first signal, and/or type of object corresponding to the first signal.

Abstract: A method performed by a processing device, the method comprising: obtaining first waveform data indicative of traversal of a first signal through a structure at a first time; applying a scale transform to the first waveform data and the second waveform data; computing, by the processing device and based on applying the scale transform, a scale-cross correlation function that promotes identification of scaling behavior between the first waveform data and the second waveform data; performing one or more of: computing, by the processing device and based on the scale-cross correlation function, a scale factor for the first waveform data and the second waveform data; and computing, by the processing device and based on the scale-cross correlation function, a scale invariant correlation coefficient between the first waveform data and the second waveform data.

Abstract: A temperature controller for simultaneously controlling the temperatures of a plurality of heating elements for use in chromatographic analysis including columns, detectors, valves, transport lines and other components.

Abstract: A system, module and method for continuous or batch single-pass countercurrent tangential chromatography are disclosed for bind/elute and negative chromatography applications. The system includes binding, washing, elution (for bind/elute), regeneration, and equilibration single-pass modules. The resin slurry flows in a continuous single pass at steady-state through each module, while corresponding buffers flow countercurrent to the slurry facilitating efficient product and impurity extraction. The module and system include retentate pumps for better process robustness and control. A resin tank configured to be reversibly isolated from the single-pass modules facilitates a closed and disposable system.

Abstract: A chromatograph mass spectrometer including: an MSn-1 analysis setter for setting an analysis execution period for performing an MSn-1 analysis, an execution time for the analysis and a loop time; an analysis period divider for dividing the analysis period into segments according to a change in number or analysis condition of MSn-1 analyses to be performed within the same time window; an MSn analysis setter for performing MSn-1 analysis to obtain mass spectrum data and for scheduling MSn analysis, an ion corresponding to a peak satisfying a set condition being designated as a precursor ion; an MSn analysis execution time allotter for allotting, in each segment, a time period for execution of the MSn analysis, the time period being calculated by subtracting an event execution time from the loop time; and an analysis executer for repeatedly performing MSn-1 analysis and MSn analysis in each segment.

Abstract: Moisture sensing color change compositions are built of nanofibers of suitable small dimension based on diacetylene monomers that are polymerized in situ in a dried film containing a hygroscopic polymer that is bound to the nanofibers either directly or through crosslinkers.

Abstract: Monitoring systems and apparatuses and methods for using same are generally described. A gas monitoring system may include a base component and a module component. The module may be configured to be operably coupled to the base component through corresponding interface connectors. The system may be monitor for gases and generate alarms relating thereto, when the module is connected to the base. The base and/or module may have limited or no functionality when disconnected from the module and/or base. The module may include components that typically have an increased potential for upgrades, replacement, maintenance, or other modifications. The base may include components that typically have a lower rate of being upgraded, replaced, or requiring maintenance. In this manner, high maintenance components may be arranged in a module that has a smaller and more portable form factor as compared to the base and the system overall.

Abstract: This identification apparatus is for identifying the degree of degradation of oil and includes a sensor that detects a substance arising from oil contained in an oil tank and a controller that determines the degree of degradation of the oil based on information related to a substance detected initially by the sensor when the oil is contained in the oil tank in an initial state and on information related to the substance detected subsequently.

Abstract: A measurement device includes a transmitter configured to transmit an interrogation signal. The measurement device also includes a receiver configured to receive the interrogation signal that has been reflected within a container. The received reflected interrogation signal corresponds to a fill level of the container. A protective barrier covers at least the transmitter or the receiver. If the protective barrier covers the transmitter, the transmitter transmits the interrogation signal through the protective barrier and the transmitter and the protective barrier are separated by a gap.

Abstract: A water quality analysis instrument for performing a blowback operation and a non-volatile total organic carbon analysis operation in sequence. When the blowback operation is performed, a previous residual gas within a water sample analyzer is discharged. When the non-volatile total organic carbon analysis operation is performed, the water sample flows between an accommodating space and an UV light providing module in a circulating manner, so that the non-volatile total organic carbon in the water sample is nearly completely oxidized, so that the water sample analyzer can analyze a content of non-volatile total organic carbon in the water sample accurately.

Abstract: Systems, apparatuses, and computer-implemented methods are provided for the real-time quantification of crude oil in an effluent from coreflooding apparatus. Disclosed here is a method of determining the amount of crude oil in an effluent from a coreflooding apparatus by blending the effluent stream with a solvent stream in a mixing device to produce a mixed stream, supplying the mixed stream to an in-line phase separator to produce a first stream containing the solvent and the crude oil from the effluent stream and a second stream containing water and water-miscible components from the effluent stream; and passing the first stream to a continuous flow analyzer to determine the amount of crude oil in the effluent stream.

Abstract: Concrete can be one of the most durable building materials where consumption is projected to reach approximately 40 billion tons in 2017 alone. Despite this the testing of concrete at all stages of its life cycle is still in its infancy although testing for corrosion is well established. Further many of the tests today are time consuming, expensive, and provide results only after it has been poured and set. Accordingly, by exploiting self-contained wireless sensor devices, which are deployed with the wet concrete, the in-situ curing and maturity measurement data can be established and employed together with batch specific concrete data to provide rapid initial tests and evolving performance data regarding the concrete cure, performance, corrosion of concrete at different points in its life cycle. Such sensors remove subjectivity, allow for rapid assessment, are integrable to the construction process, and provided full life cycle assessment.

Abstract: The present invention provides a method for testing an allergy capable of rapidly and highly accurately testing an allergic reaction. The method can determine whether or not a patient has an allergy or whether or not an agent that may be allergenic to a patient has an allergenicity (an allergic reactivity) in the patient. The method may comprise the steps of causing migration of leukocytes separated from a healthy human or cells of an established cell line with a chemotactic factor contained in a sample such as body fluid or blood of the patient to be tested or a sample stimulated with the agent that may be allergenic to the patient and analyzing the cell kinetics such as migration velocity, migration distance, and migration direction.

Abstract: Automated, image-guided systems for automatically performing in vitro cell patch clamping are provided. The systems are configured for use with a patch-clamp arrangement and include a camera system for providing images from tissues under investigation and a computer to execute calibration, detection, and whole-cell patching algorithms based on the collected image data. Automated methods for carrying out in vitro cell patch clamping using this automated, image-guided system are also provided and include using images to automatically calibrate a manipulator relative to a tissue of interest, detect and extract coordinates for a plurality of cells, and utilizing the coordinates with a patch-clamp arrangement to automatically move a manipulator directly above each of the plurality of cells and initiate the performance of an automated patch clamp mechanism for each of the plurality of cells driven by the system.

Abstract: A test meter for analyzing a body fluid sample applied to a test strip includes an outer housing having an opening, an actuator, and a cartridge positioned adjacent the outer housing. The cartridge further includes a dispensing member connected to the actuator, a plurality of stacked test strips biased toward the dispensing member, and a cartridge outer housing that is adjacent at least a portion of the dispensing member. Each time the actuator is actuated, the dispensing member is rotated to cause movement of one test strip from the plurality of stacked test strips through the opening, and another test strip is biased toward the dispensing member.

Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.

Abstract: The current invention provides methods to identify ?9?2T-cell receptors (?9?2TCR) that mediate anti-tumor responses. Surprisingly, it was now found that the CDR3 regions of the ?9-T-cell receptor chain and the ?2-T-Cell receptor chain (?2TCR chain) are of importance. Based on these findings, combinatorial-??TCR-chain-exchange (CTE) is proposed as an efficient method for identifying ?9?2TCRs that mediate anti-tumor responses. Using the method of the invention, specific sequences of the respective ?9TCR and ?2TCR chains were identified that mediate anti-tumor responses. Hence, the invention further provides for specific ?9?2TCRs, or fragments thereof, that may be used e.g. in diagnostics or treatment of cancer. The invention further provides for nucleic acid sequences, genetic constructs and retroviral vectors that can be used to express the ?9?2TCRs according to the invention.

Abstract: The present invention relates to a combination product for detecting a target marker simply and with high sensitivity. More specifically, the present invention relates to a combination product for detecting a target marker in a biological sample in combination with a target marker binding molecule which is capable of binding specifically to the target marker in the biological sample, the combination comprising, at least: (a) a first binding agent comprising a first binding molecule which is capable of directly or indirectly binding specifically to the target marker binding molecule, and a labeling substance; (b) a linker molecule which is capable of binding specifically to the first binding agent; and (c) a second binding agent which is capable of binding specifically to the linker molecule, and comprises a second binding molecule and a labeling substance.

Abstract: Described herein is a bioluminescence resonance energy transfer (BRET) based system and method to monitor ternary complex formation in real-time in live cells with high sensitivity and accuracy. This system transfers energy simultaneously between a luciferase donor and intermediate and terminal acceptors, appropriately chosen to also enable transfer from the intermediate to terminal acceptor while minimizing contaminating signals. The system may also be adapted for quaternary complex detection by including a protein complementation assay (PCA) component. The system is broadly applicable to the detection of any protein ternary/quaternary complex such as those involving nuclear receptors, GPCRs, Receptor Tyrosine Kinase (RTKs), multimeric enzymes or structural proteins.

Abstract: A method for magnetic cellular manipulation may include contacting a composition with a biological sample to form a mixture. The composition may include a plurality of particles. Each particle in the plurality of particles may include a magnetic substrate. The magnetic substrate may be characterized by a magnetic susceptibility greater than zero. The composition may also include a chargeable silicon-containing compound. The chargeable silicon-containing compound may coat at least a portion of the magnetic substrate. The biological sample may include cells and/or cellular structures. The method may also include applying a magnetic field to the mixture to manipulate the composition.

Abstract: A device for detecting an analyte includes a thermocouple having an assay polymer over a surface of the thermocouple. The assay polymer is formulated to bind to the analyte, and a heat transfer property of the assay polymer varies responsive to an amount of the analyte bound thereto. A method of forming a sensor includes providing an assay polymer over a thermocouple. A method for detecting an analyte includes passing a liquid containing an analyte adjacent a thermocouple having an assay polymer over a surface thereof, binding an analyte to the assay polymer, detecting a temperature of the thermocouple, and calculating a concentration of the analyte in the liquid based at least in part on the heat transfer property of the assay polymer.

Abstract: The present invention provides methods for predicting whether an individual having inflammatory bowel disease (IBD) is likely to respond to vedolizumab treatment. Also provided are methods for predicting whether an individual with IBD such as Crohn's disease or ulcerative colitis will develop autoantibodies against vedolizumab. The present invention also provides a treatment regimen for an IBD patient which includes measuring the level of one or more predictive markers of response to vedolizumab prior to administering the anti-?4?7 integrin drug.

Abstract: The technology described in this document can be embodied in a test strip for use in measuring a level of an ST2 cardiac biomarker in a whole blood sample. The test strip includes a base, and a plurality of conjugates, wherein each conjugate includes a reporter group bound to a first antibody that binds to ST2. A conjugate pad holds the plurality of conjugates that bind with ST2 to produce conjugate-ST2 complexes. The test strip also includes a plurality of second antibodies that bind to ST2, and a plurality of third antibodies that bind to the conjugate-ST2 complexes. The plurality of second antibodies are bound to a membrane in a test location, and the plurality of third antibodies are bound to the membrane in a control location. A plasma separation pad passes blood plasma from a whole blood sample to the conjugate pad while inhibiting other components.

Abstract: This disclosure provides a method for detecting infection of an animal by Mycobacterium bovis. The method generally includes obtaining a biological sample from a host animal at risk of being infected by Mycobacterium bovis and analyzing the sample for the presence or absence of at least one M. bovis polypeptide. In some embodiments, the method can further include analyzing the sample for the presence or absence of at least one M. bovis lipid. In some embodiments, the method can further include detecting at least one host polypeptide whose expression is greater in a host infected with M. bovis compared to expression in a host known to be uninfected with M bovis.

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

Abstract: Provided herein are nucleic acid tags that are linked to, or capable of linking to, a protein of interest. In particular, the nucleic acid tags are oligonucleotides comprising a reporter function and a protein tagging function. Also provided herein, are nucleic acid tag compositions, kits and methods of use thereof.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Cathepsin B, Renin, Dipeptidyl Peptidase IV, Neprilysin, Beta-2-microglobulin, Carbonic anhydrase IX, and C-X-C motif chemokine 2 as diagnostic and prognostic biomarkers in renal injuries.

Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.

Abstract: A method of predicting the risk of developing osteoarthritis (OA) comprising: (a) measuring the nuclear cellular level of prohibitin (PHB-1) in nucleated cells present in a blood sample from a subject having or suspected of having OA; and (b) comparing said nuclear cellular level to that corresponding to a control sample; and (c) identifying the subject as being at risk of developing OA when the nuclear cellular level of said PHB-1 in said blood sample is higher than in the control sample; and a composition for determining the risk of developing osteoarthritis (OA), said composition comprising: a cell sample from a subject; and a non-naturally occurring molecule for detecting nuclear accumulation of PHB1.

Abstract: Methods for the diagnosis and prognosis of neurodegenerative diseases, such as Alzheimer's disease, are described. Compositions and method for the treatment of neurodegenerative diseases are also described.

Abstract: A method for measuring bilirubin levels in a subject. The method can include the steps of providing a sample to be measured from the subject, wherein the sample comprises bilirubin bound to albumin; adding a release agent to the sample, the release agent configured to release the bound bilirubin from the albumin; measuring electrochemical data of the sample using an electrochemical cell; and determining a total serum bilirubin concentration of the sample using the electrochemical data. This method is capable of providing a simpler, faster, and more robust measurement when compared to traditional bilirubin assay methods.

Abstract: Newly identified mammalian taste-cell-specific G Protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are believed to be involved in bitter taste sensation, and the genes encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating a novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes.

Abstract: Provided herein are novel assays for the measurement of androgens such as testosterone in a sample. The assays utilize sensitive androgen receptor mutants and have much greater sensitivity than assays based on wild-type androgen receptors. The assays of the invention can detect androgens at concentrations as low as 1 ng/dl in serum, urine, environmental samples and other samples. The invention encompasses novel assay methods as well as nucleic acid sequences, proteins, and cells. Advantageously, the assays provide a measure of physiologically relevant androgen concentrations in a sample, taking into account the presence of androgen-binding factors or anti-androgen drugs in serum.

Abstract: The present invention provides methods for quantifying an amount of plasmalogens in samples with high accuracy in an easy, convenient and inexpensive manner by using a hydrolysis processing to samples and a lipid extraction followed by the measurement using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD) or Mass Spectrometer (MS), a fluorescence plate reader or a plate reader. The present invention also relates to a method for examining a subject by using the above method, a biomarker for disease detection, a method for using the biomarker for the disease detection, as well as a kit for the disease detection.

Abstract: Apparatus for automating a high volume instrument (HVI) used for the classification of all Upland and American Pima cotton, including determining trash and color. A sub-sample delivery tube sub-system and a sample drum air chamber sub-system allow the HVI to receive sub-samples from an automated cotton system. A delivery tube, with an air dissipater, delivers the automated sub-sample to the HVI sample drum while an air chamber below the sample drum applies a negative air pressure to the drum. A sub-sample air-knife extraction sub-system and an autoMIC transfer tube assist sub-system allow the HVI to release automated sub-samples after the sample drum in the HVI has completed its operations on the sub-sample. An air-knife applies air jets to the sample plate of the HVI sample drum to release the sub-sample. As the sub-sample leaves the drum an air jet is actuated to push the sub-sample along a transfer tube.

Abstract: Automated apparatus and methods for dispensing fluids into microplates utilizing microwell covers, the covers comprising open portions to allow a pipette access to one or more wells and impermeable portions which prevent the fluids from getting into wells shielded by the impermeable portion. The open portions and impermeable portions are preferably arranged and sized to align with alternating rows of wells in a particular microplate. Preferred covers are movably positioned on the microplate. Automated dispensing apparatus for use with microplates and microwell covers comprises a programmable controller, and suitable interfaces which allow the apparatus to be programmed, and which control a dispensing head such that pipettes are moved in the desired manner in order to take advantage of the protective features of the microwell covers. The apparatus also preferably comprises at least one transfer mechanism for moving a cover relative to a microplate at a dispensing station.

Abstract: An impulse ring centered on a central axis, for a sensor-bearing unit including a bearing is provided. The impulse ring includes a magnetized target that generates a magnetic fields adapted to be sensed by a sensor, and an annular target holder. The target holder provides an inner axial tubular portion adapted to be fixed to a rotatable inner ring of the bearing, an outer axial tubular portion holding the magnetized target that is positioned radially beyond an outer ring of bearing, and an intermediate portion that radially extends between the inner axial tubular portion and outer axial tubular portion. The intermediate portion provides a radial part, an inclined part and a plurality of stiffening ribs.

Abstract: A monitoring device includes a cavity assembly with a plurality of cavities. Openings of the plurality of cavities are distributed about a flow-facing surface of the cavity assembly. A gas pressure sensor is disposed within each of the cavities, and is configured to measure an absolute pressure of a gas flow which flows past the monitoring device. Gas pressure measurements from the pressure sensors may be used to determine a flow speed and a flow direction of the gas flow. More specifically, a mapping may be used to map the logarithm of the difference between the maximum and minimum pressures to a flow speed. Further, a lookup table may be used to map a pattern of pressure measurements to a flow direction.

Abstract: Mechanical low pass filters for motion sensors and methods for making same are disclosed. In some implementations, a motion sensor package comprises: a substrate; one or more mechanically compliant dampers formed on the substrate; one or more mechanically compliant metal springs formed on the one or more dampers and the substrate; and a sensor stack attached to the one or more metal springs, wherein the one or more metal springs and dampers provide a mechanical suspension system having a resonant frequency that is higher than a sensing bandwidth of a motion sensor in the sensor stack and lower than a resonant frequency of the motion sensor.

Abstract: A physical quantity sensor has a first movable electrode section which has a portion facing a first fixed electrode section and a second movable electrode section which has a portion facing a second fixed electrode section, and is provided with a movable mass section which is formed in a shape which encloses a first fixed electrode side fixed section, a second fixed electrode side fixed section, a first movable electrode side fixed section, and a second movable electrode side fixed section in planar view.

Abstract: Provided is a highly reliable acceleration sensor having little 0-point drift. For example, an acceleration sensor having a support substrate having a first direction and a second direction orthogonal thereto in a single surface, a device layer disposed on the support substrate with a space interposed therebetween and having a weight that deforms according to the application of acceleration, and a cap layer disposed on the device layer with a space interposed therebetween, wherein a fixed part fixed to the support substrate is provided in the center of the weight, a beam is provided that extends from the fixed part and makes the weight mobile by being connected thereto, a plurality of posts for coupling the support substrate and the cap layer are disposed on the fixed part, and electric signals are applied to and received from the weight via the posts.