Abstract: A method for dynamic dosing of disinfectant solution in a medical device reprocessing system includes calculating a volume of an initial dose of concentrated disinfectant solution for dilution to make a first in-use disinfectant solution. The initial dose of concentrated disinfectant solution is diluted with diluting fluid to make the first in-use disinfectant solution comprising a target concentration of disinfectant agent. The first in-use disinfectant solution is applied to a medical device. A concentration of the disinfectant agent in the first in-use disinfectant solution is then calculated. The actual concentration of the disinfectant agent in the concentrated disinfectant solution is then calculated based upon the concentration of disinfectant agent in the first in-use disinfectant solution. It is then determined whether a volume of a second dose of concentrated disinfectant solution is increased or about the same as the volume of the initial dose to make a second in-use disinfectant solution.

Abstract: An air freshener for a vehicle includes a housing having an air inlet and an air outlet at both ends thereof. A perfume container is provided inside the housing, in which a plurality of aromatics having different physical states are laminated. An aromatics laminated at an uppermost layer is evaporated by air passing through an interior of the housing.

Abstract: Aspects of the disclosure include an attachment for providing a scent to a container. The scented attachment may be configured for being associated with a container, such as a drink or a food storage container. In one instance, the attachment is of a size or shape so as to fit around a circumference of the container. In another instance, the attachment may be configured for being associated to the container with a suitable attachment mechanism. For instance, the attachment may include a substrate having a first surface comprising an attachment mechanism for associating the scented attachment to the container; and a second surface comprising a scent. Systems including a scented attachment and a container, including their methods of use, are also provided.

Abstract: A long-acting ultrasonic dispenser that effuses a water-based deodorizer solution into ambient air as a dry fog in a closed environment, and a method for deodorizing noxious odors in that closed environment by the dry fog. The dry fog, containing the deodorizer, chemically reacts with materials producing the odors, thereby neutralizing them. The dispenser contains an electronic ultrasonic wave generator comprising a piezoelectric crystal and an ultrasonic membrane, which is always submerged under liquid. As the liquid evaporates, droplets larger than five microns are filtered out, and the remaining dry fog is emitted into the air. The dispenser is connected to a large reservoir. When the liquid level reaches a minimum permissible height, additional deodorizer solution is pumped into the dispenser. This system is ideal for use with central air conditioners in large office buildings to eliminate odors over a long period of time with minimum maintenance.

Abstract: A portable microorganism sanitation system produces UV light and air treatment for treating an enclosed space, such as a room. A portable microorganism sanitation system incorporates a plurality of UV light sources configured around a lamp tower having reflective surfaces to produce emitted UV and reflected UV light in a wide range of angles. This wide range of angles of the emitted and reflected UV light enables more complete and direct impingement of UV light on surfaces in the enclosure or room. The portable microorganism sanitation system also incorporates active air treatment, wherein an air moving device draws airflow into a conduit inside of the lamp tower and then through airflow outlets. The airflow outlets are configured to expose the outlet airflow to the UV light sources, thereby treating the airflow to destroy microorganism therein. Photocatalyst may be configured on the surfaces of the lamp tower to promote microorganism destruction.

Abstract: Described are polymers and methods of forming and using same.

Abstract: Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate. The proteinaceous substrate includes one or more proteins and a polyamine, where the polyamine and a proteinaceous substrate are present in synergistic viscosity enhancing amounts, and may also include one or more of: a carbohydrate, a tackifying agent, a plasticizer, or other modification agent. In certain embodiments, the crosslinker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

Abstract: The present invention includes a method for treating penile implant infections that uses a synthetic high-purity calcium sulfate mixed with antimicrobials, which is capable of providing prolonged exposure of antimicrobials to the infection site and capable of acting as an intracorporal filler preventing fibrosis and loss of phallic length. The technique is especially useful for high-risk patients, and provides another medium for which antimicrobial agents can be delivered to a surgical infection site while at the same time acting as a filler, preventing fibrosis, and loss of the space. The antimicrobial cast lasts 4-6 weeks, making timely re-implantation easier, and preventing intracorporal fibrosis and loss of phallic length.

Abstract: The present invention relates to an implant (10) comprising: —a substrate (1) the surface of which comprising oxidized cellulose, said oxidized cellulose having a degree of oxidation ranging from 0.0 to 1, and —a multilayer coating covering said substrate, said multilayer coating comprising at least a first layer (2) adjacent said substrate, said first layer being formed of chitosan, and a second layer (3) adjacent said first layer, said second layer being formed of oxidized cellulose having a degree of oxidation ranging from 0.5 to 1. The invention further relates to a method for preparing such an implant.

Abstract: An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.

Abstract: Disclosed herein are soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and pharmaceutically acceptable salts thereof. In one aspect, hyaluronic acid-based compositions described herein include a therapeutically effective amount of at least one anesthetic agent, for example, lidocaine. The present hyaluronic acid-based compositions including lidocaine have an enhanced stability, relative to conventional compositions including lidocaine, for example when subjected to sterilization techniques or when stored for long periods of time. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.

Abstract: A method for producing a ceramic osseoconductive bone substitute material, the bone substitute material, intervertebral disk implants containing the substitute bone material, and to methods of using the bone substitute material.

Abstract: Compositions, devices, grafts and methods for reducing or preventing anti-neointima following cardiovascular injuries and interventions are disclosed. The compositions, devices, and grafts typically include an effective amount of a CTP synthase 1 inhibitor to reduce proliferation of vascular smooth muscle cells, without substantial reducing the proliferation of endothelial cells. Methods of reducing neointima formation, accelerating re-endothelialization, and reducing restenosis in a subject using the compositions, devices, and grafts are also disclosed.

Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.

Abstract: The current invention discloses a wound treatment device having a wound covering member, an applicator unit, and two lumens. The wound covering member may cover a wound. Sealing mechanism of the wound covering member may be used to form a sealed wound enclosure over and around the wound. The two lumens, including a negative pressure lumen and an oxygen lumen, connect the wound enclosure to the applicator unit. The applicator may be used to apply alternating and cycling negative pressure and oxygen to the wound enclosure, facilitating the wound healing process. The levels and durations of negative pressure, as well as the purity, amount, and durations of oxygen, may be adjusted by the applicator unit.

Abstract: In one example embodiment, an apparatus for providing negative-pressure therapy may comprise a negative-pressure source, a pressure sensor, and a control valve. The negative-pressure source may be configured to be fluidly coupled to a distribution component. The control valve may be fluidly coupled to the pressure sensor and configured to be selectively coupled to the negative-pressure source, the distribution component, or both. A controller may also be configured to operate the control valve to selectively couple the pressure sensor to at least one of the negative-pressure source and the distribution component through the control valve, and the pressure sensor may provide a feedback signal to the controller indicative of pressure in a feedback path associated with the position of the control valve. The controller may also be configured to operate the negative-pressure source based on the feedback signal.

Abstract: A device for the drainage of a pleural effusion through an operatively engaged chest tube in the chest wall. The device employs a check valve situated between a vacuum source communicating with the chest tube to prevent reversal of the fluid flow out of the patient's body and possible contamination. A valve mounted on a vacuum bottle provides user control of communication of negative pressure from the vacuum bottle to the chest tube. Opening the valve on the bottle communicates negative pressure to the chest tube relative to the pressure in the tube thereby initiating a fluid flow out of the tube and the patient. Once the valve on the bottle is closed, fluid flow ceases and the check valve prevents reversal of the flow.

Abstract: Methods and apparatuses for detecting full waste canister and/or fluid flow path blockage conditions are disclosed. Also disclosed are methods and apparatuses for controlling a pump. In some embodiments, flow of fluid can be restricted in a portion of the fluid flow path. A controller can be configured to compare a difference in pressure values upstream and downstream of a fluid flow restrictor to a pressure difference threshold, and determine based on the comparison whether to activate an alarm indicating the full waste canister condition or the fluid flow path blockage condition. The controller can be additionally or alternatively configured to determine a fluid flow using a flow meter, open a selectable valve in response to a comparison of the fluid flow with a fluid flow threshold, determine fluid flow after opening the valve, and determine based on the fluid flow after opening the valve whether to activate the alarm.

Abstract: Embodiments of reduced pressure systems and methods for operating the systems are disclosed. In some embodiments, a system can include a source of negative pressure and a controller configured to present GUI screens for controlling and monitoring operation of the system. The controller can be configured to receive, via the GUI, an adjustment of a negative pressure therapy parameter and adjust (or cause adjustment) of the operation of the negative pressure source based on received adjustment. The controller can be further configured to record historical data parameters associated with negative pressure therapy parameters. The controller can also be configured to transmit (or cause transmission) over a communication channel at least some of recorded historical data. The system can be configured to provide external connectivity for accomplishing various activities, such as location tracking, compliance monitoring, tracking of operational data, remote selection and adjustment of therapy settings, etc.

Abstract: Methods and systems for reducing bacterial contamination of platelets are disclosed. The methods and systems disclosed herein provide for the processing of a pre-determined volume of whole blood so as to reduce the risk that platelets separated and collected from the whole blood have a reduced risk of bacterial contamination.

Abstract: A method of implanting a blood pump in a heart of a mammalian subject includes maintaining a temporary plug in an inlet opening of a pump having a pump body and an outlet cannula projecting from the pump body, advancing the pump into a ventricle of the heart through a hole in a wall of the heart so that the inlet of the pump is disposed within the ventricle and the outlet cannula extends through a valve of the heart into an artery, and then withdrawing the temporary plug from the inlet of the pump.

Abstract: An improved intravascular blood pump and related methods involving the broad inventive concept of equipping the intravascular blood pump with guiding features such that the intravascular blood pump can be selectively positioned at a predetermined location within the circulatory system of a patient.

Abstract: A control unit (30) is arranged to control a dialysis fluid distribution system (12) comprising two volumetric pumps (P1, P2) and a dialyzer (13). The control unit (30) is operable in a calibration mode, to establish a bypass flow path that bypasses the dialyzer (13) and extends between the pumps (P1, P2) and to operate the pumps (P1, P2) at first and second calibration speeds so as to balance the flow rates generated by the pumps (P1, P2), e.g. based on a measured pressure or fluid level in dialysis fluid distribution system (12). The control unit (30) determines, based on the first and second calibration speeds, a relation between the stroke volumes of the pumps (P1, P2).

Abstract: The blood treatment apparatus described herein include a plurality of treatment solution reservoirs connected to a junction which feeds an output controller through an output line. The reservoirs feed the junction through one or more liquid-gas separation filters that limit or prevent air from passing. One or more of the reservoirs can typically be emptied during a treatment session without drawing air into the system.

Abstract: An arrangement and a method for cardiopulmonary bypass is provided. The arrangement includes a reservoir configured to receive blood from the cardiotomy of a patient. An oxygenator receives the blood from the reservoir. An arterial connection is connected to the patient for supplying the blood from the oxygenator. A pump is provided for pumping the blood through the oxygenator to the arterial connection and the patient. The arrangement includes a supply device including a supply conduit attached to the reservoir. The supply device supplies a displacing gas to the reservoir via the supply conduit.

Abstract: A system and method enabling the receipt of image data of a patient, identification of one or more locations within the image data depicting symptoms of lung disease, analyzing airways and vasculature proximate the identified locations, planning a pathway to the one or more locations, navigating an extended working channel to one of the locations, identifying the direction of blood flow within vasculature serving the location, positioning a catheter proximate the location, and temporarily isolating a portion of the identified vasculature serving the location depicting symptoms of lung disease.

Abstract: Systems and method for peripheral cannulation are provided. Systems include cannulas defining fenestrations that can be exposed or occluded by a cover slip to selectively expose fenestrations to blood flow in an artery or vein.

Abstract: A pen needle (501) includes a hub (531) and a needle (521) fixedly connected to the hub (531). An outer cover (511) removably receives the hub (531) and the needle (521). The outer cover (511) has a first gripping member (515) to facilitate removal of the outer cover (511) from the hub (511). A sealing member (541) is removably connected to the outer cover (511). The sealing member (541) has a second gripping member (543) to facilitate removal of the sealing member (541) from the outer cover (511). The first and second gripping members facilitate manipulation of the pen needle by a user with reduced dexterity or a physical or visual impairment.

Abstract: The present invention relates to a workpiece carrier for transporting or storing components of a drug delivery device, comprising: an array of accommodating recesses extending in a first lateral plane (x, y) and being adapted to receive at least one component of the drug delivery device, at least one stack forming structure adapted to mate with a corresponding stack forming structure of another workpiece carrier for mutually aligning workpiece carriers when stacked on one another, wherein the center of the at least one stack forming structure is arranged laterally offset with respect to the center of the array of accommodating recesses in at least one lateral direction, and wherein the stack forming structure comprises a surrounding edge comprising at least in sections a corrugated or undulated structure.

Abstract: A medication delivery monitoring device is disclosed. The device includes a user interface configured to receive input information, and a sensor configured to measure a plurality of fluid state parameters of a fluid delivery channel through which the medication is delivered by a vascular access device (VAD) to an infusion site region of the patient. The device also includes a processor configured to determine a state of the infusion site region based on the plurality of measured fluid state parameters and the input information, and an output device configured to provide a communication regarding the state of the infusion site region. Methods and computer-readable mediums for monitoring medication delivery are also disclosed.

Abstract: A medical pump or the like provides for a multi-function flow monitor that provides for capacitive plates positioned on opposite sides of the IV line to sense changes in the electrical environment within the IV line to deduce IV line pressure, the presence of IV fluid bubbles, the presence of the IV line within the pump, and/or correct pump operation. Each of these conditions may be determined by different analysis of the capacitance across the capacitive plates.

Abstract: Method and apparatus including calling, retrieving and/or initiating a programmed function in conjunction with execution of one or more commands related to a closed loop control algorithm, receiving one or more data in response to the one or more commands over a data interface, and executing the one or more commands related to the closed loop control algorithm based on the received one or more data are provided.

Abstract: Methods and systems are provided for determining fluid administration. The system may determine fluid administration based on the fluid responsiveness and regional oxygen saturation of a subject. The system may receive the fluid responsiveness and regional oxygen saturation from external sources or may determine one or both based on received physiological signals. In some embodiments, the system may determine whether to administer fluid based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the amount of fluid to administer based on the fluid responsiveness and regional oxygen saturation. In some embodiments, the system may determine the effectiveness of fluid administration. In some embodiments, the system may provide an indication of the determined fluid administration so that a care-giver can implement the appropriate fluid administration. In some embodiments, the system may control the fluid administration based on its determination.

Abstract: A system for use with a drug delivery device includes a sensor unit and a deactivation unit operatively coupled to an output of the sensor unit and to a drug-retaining region of the drug delivery device, wherein the drug-retaining region contains a drug. The sensor unit is configured to detect a characteristic of a local environment and generate an output corresponding to a value of the detected characteristic. The deactivation unit is configured to render the drug ineffective when the output of the sensor unit satisfies a predetermined condition.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: A drug delivery device configured to provide a dose of medicament is disclosed. The drug delivery device includes a main housing, a syringe arranged in the main housing, and a pneumatic power pack arranged in the main housing. The pneumatic power pack includes a pressurized gas source storing pressurized gas, a valve for the pressurized gas source, a sleeve having an inner wall, and a plunger. The sleeve is configured to receive pressurized gas released from the pressurized gas source. The plunger is in sliding gas-tight engagement with the inner wall of the sleeve. Upon activation of the valve, the valve releases the pressurized gas, and the released pressurized gas flows into the sleeve and propels the plunger in a distal direction with respect to the sleeve and the syringe, so as to eject medicament from the syringe.

Abstract: An automatic applicator of injection is described, which is equipped with a programmable electronic module that activates a first linear motor (ML1) which axially displaces an arm (13) of the proximal end (11) to the fixed head (20) placed at the distal end of the housing (10), said arm (13) which compresses a cartridge (15) fitted in the chamber (12) formed between the head (20) and the free end of the arm (13) so as to gradually expel the fluid stored in the cartridge; and a second linear motor (ML2) actuated concurrent with the first linear motor (ML1), said second linear motor (ML2) retreating an arm (60) with a dragger (61) which slides axially a suction chamber (30) toward the intermediate portion of the housing (10) and contiguous to the outer surface of the inner chamber (12), gradually exposing the needle tip (50) for application of the injection.

Abstract: A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap holder assembly containing a cap and an absorbent material removably attached to the syringe.

Abstract: A syringe for use in pressurized injection of a fluid is provided herein. The syringe includes a syringe barrel comprising a polymeric material having undergone expansion by stretch blow molding and by compression molding of an inner diameter of the barrel with a core member. In certain configurations of the syringe barrel, the stretch blow molding is provided through a nozzle of the syringe. Similarly, according to a further embodiment, a syringe for use in pressurized injection of a fluid is provided. The syringe includes a syringe barrel comprising a polymeric material having undergone expansion by stretch blow molding and by shrinking an inner diameter of the syringe barrel about a core member.

Abstract: An assembly (100) for a drug delivery device is presented. The assembly comprises a housing (10) with a main axis (X), a dose setting member (2) being rotatable with respect to the housing (10) for setting a dose of a drug, an activation member (1) being axially movable with respect to the housing (10) for dispensing the dose from the drug delivery device, and a rotation member (5) being arranged between the activation member (1) and the dose setting member (2). The assembly (100) is configured such that the rotation member (5) is rotatable with respect to the dose setting member (2) and the activation member (1), wherein the outer surface (21) of the assembly (100) comprises the outer surface (22) of the rotation member (5).

Abstract: The invention relates to a non-axial working End-of-Content mechanism which is geared by a hypocycloid gearing. The EoC mechanism comprises a first element (30, 109) having a first internal surface (36, 136) with a first internal diameter (D), and an EoC element (50, 150) having a second external surface (56, 156) with a second external diameter (d) being smaller that the first internal diameter (D). The EoC element (50, 150) is located inside the first internal diameter (D) of the first element (30, 109) and the first element (30, 109) and the EoC element rotates relatively to each other in a gearing ratio. The EoC element (150, 150) thus operating as the inner rolling circle of a hypocycloid counting the numbers of relative rotations.

Abstract: An automatic accurate dose syringe includes a barrel, a plunger seal, a barrel adapter assembly having a barrel tip and a needle, and a dose control mechanism having a plunger having a coarse pitch screw on its exterior surface, a housing having a corresponding coarse pitch guide along the interior surface of the housing, a screw having a fine pitch screw which interfaces with a fine pitch nut of an adapter, wherein the plunger has an internal annular space within which screw at least partially resides. The syringe further includes a locking mechanism, an activation button, and a biasing member such as a compression and/or a torsional spring. The components are configured such that actuation of the activation button by the user manipulates the locking mechanism to permit the biasing member to move from an initial energized state to a lower energy state, thereby automating drug delivery from the syringe.

Abstract: A syringe is provided having a hub with an orifice, first and second barrels having interior surfaces to form respective lumens, a slider, and an optional test indicator. The first and second barrels slideably receive respective first and second plungers for movement therein. The slider is operable to provide a fluidly communicative path between the orifice of the hub and the first and second barrel lumens. The optional test indicator is responsive to at least one characteristic of bodily fluid, the test indicator positioned to be exposed to any bodily fluid drawn into the first barrel lumen and visible from an exterior of the first barrel.

Abstract: Methods and apparatus are provided for treating tissue with apparatus that includes an priming portion for initiating a healing response in the tissue to be treated, and which delivers a bioactive agent during or after preparing tissue adjacent the apparatus, as by generating or aiding a healing, regeneration or repair response in the tissue. The priming portion may comprise an abrasive surface, fluid ejection ports, and/or stimulation by electrical, thermal, or light energy.

Abstract: A syringe guide includes: a syringe receiver including a receptacle configured to retain a syringe therein; a depth guide defining a reference surface; and a depth adjustment mechanism interconnecting the syringe receiver and the depth guide, and operable to change a distance between the receptacle and the reference surface.

Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Abstract: A method of manufacturing a flowable and dispersible powder includes solubilizing a lipophilic substance in a terpene to form a mixture and treating the mixture to form a nanoemulsion dispersed in an aqueous solution. The aqueous solution includes at least one functional excipient. The nanoemulsion is then spray dried, thereby evaporating first the aqueous portion and then the terpene to form a dry powder formed from solid particles comprising the lipophilic substance.

Abstract: An oral device for use with a person in which at least one non-toxic gas pulse is delivered to a predetermined location in the mouth via a device conduit. The oral device may be provided as a kit with at least one device for measuring the subject's responses and representing them as feedback to the subject/clinician. A method of creating a gas bolus pulse train, delivering it to a predetermined mouth area, and monitoring the subject's responses to it, is also shown. The oral device and method may be used as a diagnostic tool, or a therapeutic tool, in swallowing or speech rehabilitation of children and adults who have swallowing, speech, salivary, and/or oral sensorimotor impairments.

Abstract: A nebulizer system includes a body having a fluid chamber and an aerosol chamber, and a vibrator assembly positioned at an interface between the fluid chamber and the aerosol chamber. The vibrator assembly may include a diaphragm, having a fluid side and an aerosol side, defining a plurality of perforations between the fluid side and the aerosol side, and one or more vibrator elements operatively associated with the diaphragm to vibrate the diaphragm to produce aerosolized medicament projected into the aerosol chamber from the plurality of perforations. Each perforation of the plurality of perforations projects the aerosolized medicament along a respective projection path relative to a plane defined by the aerosol side of the perforation, the one or more vibrator elements or the diaphragm support substrate further being configured to angularly displace the aerosol side of the diaphragm to sweep the direction of at least one projection path.

Abstract: Automated methods provide leak detection that may be implemented in a respiratory treatment apparatus. In some embodiments, the detection apparatus may automatically determine and score different types of leak events during a treatment session, including, for example, continuous mouth leak events and valve-like mouth leak events. The detection methodologies may be implemented as a data analysis of a specific purpose computer or a detection device that measures a respiratory airflow or a respiratory treatment apparatus that provides a respiratory treatment regime based on the detected leak. In some embodiments, the leak detector may determine and report a leak severity index. Such an index may combine data that quantifies different types of leak events.