Abstract: The invention provides methods and kits for detecting, screening, quantifying or localizing the etiology for reduced or impaired cranial nerve function or conduction; localizing a central nervous system lesion; detecting, diagnosing or screening for increased intracranial pressure, pressure or disruption of central nervous system physiology as seen with concussion; or detecting, diagnosing, monitoring progression of or screening for a disease or condition featuring increased intracranial pressure or concussion by tracking eye movement of the subject. The invention also provides methods and kits useful for detecting, screening for or quantitating disconjugate gaze or strabismus, useful for diagnosing a disease characterized by disconjugate gaze or strabismus in a subject, useful for detecting, monitoring progression of or screening for a disease or condition characterized by disconjugate gaze or strabismus in a subject or useful for quantitating the extent of disconjugate gaze or strabismus.

Abstract: A micro-device and system for monitoring cervical tissue includes micro-circuitry for simulating electrochemical impedance spectroscopy and a system for monitoring the physiological condition of the cervical tissue.

Abstract: New systems, devices and methods for testing, analyzing and managing skin and skin microbiomes are provided. According to some embodiments, a skin and skin microbiome testing and management system is provided, including at least one computer hardware- and software-based control system and a wand device with rapidly replaceable testing and application cartridges comprising rollers. In some embodiments, the control system enrolls user(s) and issues testing kits to the user(s), including the specialized wand device, testing substrates and reagents. In some embodiments, techniques for sampling and testing a skin microbiome are set forth. Further techniques for analyzing skin conditions, based on the results of that testing, and issuing management techniques based on those results, are also provided.

Abstract: A Wound Moisture and Assessment System includes a flexible coupon containing one or more electrochemical moisture sensors for measuring a moisture profile of a wound. The coupon is activated by a wireless RF scanner that provides power to the coupon for taking moisture measurements, receives the moisture measurements therefrom, and transmits the measurements to a computing device. The moisture measurements can be represented as a wound moisture map that allows a patient or caregiver to assess the health and healing progress of a wound such as an ulcer.

Abstract: Disclosed is a method with different exemplary embodiments for determining a degree of damage to hair. Said method can comprise the following steps: during the exposure of a hair sample to near-infrared and/or infrared light, recording a spectrum of at least part of the near-infrared and/or infrared light that has interacted with the hair sample, comparing at least part of the spectrum with a spectroscopic calibration model obtained by near-infrared and/or infrared spectra and degrees of damage of a plurality of calibration hair samples, and determining the degree of damage to the hair using said comparison.

Abstract: The present disclosure pertains to a system and method for determining sleep onset latency in a subject. The system is configured to generate output signals conveying information related to brain activity in the subject, determine sleep stages of the subject based on the output signals, determine a sleep onset moment in the subject based on the determined sleep stages, determine a sleep intention moment for the subject by: (i) detecting eye blinks in the subject based on the output signals, and determining the sleep intention moment responsive to the detected eye blinks ceasing for a predetermined period of time; and/or (ii) determining whether brain activity power in a target frequency band has breached a threshold power level based on the output signals, and determining the sleep intention moment responsive to a breach; and determine the sleep onset latency based on the sleep onset moment and the sleep intention moment.

Abstract: The present disclosure pertains to a system configured to facilitate prediction of a sleep stage and intervention preparation in advance of the sleep stage's occurrence. The system comprises sensors configured to be placed on a subject and to generate output signals conveying information related to brain activity of the subject; and processors configured to: determine a sample representing the output signals with respect to a first time period of a sleep session; provide the sample to a prediction model at a first time of the sleep session to predict a sleep stage of the subject occurring around a second time; determine intervention information based on the prediction of the sleep stage, the intervention information indicating one or more stimulator parameters related to periheral stimulation; and cause one or more stimulators to provide the intervention to the subject around the second time of the sleep session.

Abstract: A system and method for positioning a pill to be ingested by a user in a field of view of an image acquisition camera. The method includes the steps of determining a desired location of the mouth of a user in a field of view of an image acquisition camera, determining a current position of a pill to be ingested by the user in the field of view of the image acquisition apparatus, and indicating on a display a movement to be made by the user to move the pill towards mouth of the user.

Abstract: Methods, devices, and kits are provided for determining a recommended insulin dose to be administered to user based upon analyte data determined by an analyte sensor.

Abstract: The present disclosure provides alert implants that comprise a medical device and an implantable reporting processor (IRP), where one example of such a medical device includes a component for a total knee arthroplasty (TKA) such as a tibial extension, a femoral component for hip replacements, a breast implant, a distal rod for arm or leg breakage repair, a scoliosis rod, a dynamic hip screw, a spinal interbody spacer, and tooling and methods that may be used to form the alert implant, and uses of such alert implants in the health maintenance of patients who receive the implant.

Abstract: Method and apparatus for monitoring eating behavior are disclosed. A wearable device including an imaging sensor, an electromyography (EMG) sensor, and a processing unit is configured to collect EMG data via the EMG sensor, transmit the EMG data to a computing device, receive a control signal to capture one or more images via the imaging sensor, capture, one or more images, and transmit the one or more images. A computing device is disclosed including a processor and a memory containing a machine learning model and computer program code that, when executed, performs an operation. The operation includes receiving EMG data, processing the EMG data as input to a trained machine learning model, transmitting the control signal to capture one or more images via the imaging sensor, receiving the one or more images, and determining nutritional content of the food or beverage using the one or more images.

Abstract: Disclosed herein is a system for determining a subject's stress condition. The system includes a stress test unit configured for: receiving features defining the subject and physiological signals sensed from the subject when performing a relaxation and a stressful test task; extracting normalization parameters from the physiological signals; and identifying stress-responsive physiological features. The system also includes a storage unit configured for: storing a plurality of stress models; and storing the subject's features, normalization parameters, and the stress-responsive physiological features.

Abstract: An addition of auxiliary functions to the multimedia equipment not included inside. These functions can be function of physiological data processing, extended and/or uninterrupted operations with regard to monitored and processed data. Auxiliary functions are implemented by the auxiliary equipment and circuits solutions physically placed in the original equipment or out of it but mechanically and electrically connected by it, whereas can it formed one compact unit. The parts, which are necessary to be during operation changed to get uninterrupted functions, are user friendly and simply exchangeable from the aspects of users.

Abstract: An embodiment of the present disclosure seeks to select characteristics of incoming intensity data that cause comparisons of selected characteristics to produce defined probe off space having reduced crossover with defined probe on space. Once defined, the present disclosure compares characteristics of incoming intensity data with the now defined probe off space, and in some embodiments, defined probe on space, to determine whether a probe off condition exists. When a processor determines a probe off condition exists, the processor may output or trigger an output signal that audibly and/or visually indicates to a user that the optical sensor should be adjusted for a proper application to a measurement site.

Abstract: A system for sensing in-ear electrical signals includes a left electrode tip, a right electrode tip, and a signal acquisition subsystem. Each electrode tip includes: an elastic substrate configured to conform against an internal surface of an ear canal of a user; a sense electrode, a reference electrode, and a driven ground electrode each arranged on the outer surface of the elastic substrate. The signal acquisition subsystem is configured to, during a sampling period: output a left time series of a left voltage differential between the left sense electrode and the right reference electrode; and output a right time series of a right voltage differential between the right sense electrode and the left reference electrode.

Abstract: An electroencephalogram (EEG) sensor is disclosed. The EEG sensor includes a housing defining a chamber capable of storing a gel, the housing includes a first and a second chamber wall, the walls each comprising a corresponding access port located on a common axis extending through the housing; an electrically-conductive probe with a probe tip extending at least partially through the chamber along the axis, at least a portion of the probe tip being exposed to the chamber; an electrical terminal located at an outer surface of the second chamber wall, the electrical terminal being in electrical communication with the probe tip through the access port at the second chamber wall; and a compliant member mechanically coupled to the access port at the first chamber wall capable of compressing, thereby providing a dispense pathway from the chamber through the access port at the first chamber wall.

Abstract: A system for motion artifact reduction in a photoplethysmogram, PPG, signal representing heart activity of a subject, comprises: a processing unit, said processing unit being configured to: receive a PPG signal carrying information of heart activity of the subject; receive a motion reference signal carrying information of a motion of the subject; form a PPG time-frequency representation, based on the PPG signal, and a motion reference time-frequency representation, based on the motion reference signal; and subtract a weighted representation of the motion reference time-frequency representation from the PPG time-frequency representation for reducing a motion artifact component in the PPG time-frequency representation and form a cleaned time-varying frequency spectrum of the PPG signal.

Abstract: Embodiments include a method and system for providing data to a user of a wearable sensor platform. The method may be performed by a least one software component executing on at least one processor. The method includes capturing data for the user using at least one sensor in the wearable sensor platform. The data includes physiological data and artifact data. The physiological data includes noise data therein. A confidence indicator for the data is determined based on at least one of the physiological data and the artifact data. A physiological data signal corresponding to the physiological data and the confidence indicator is provided to the user on the wearable device platform.

Abstract: The present disclosure relates to a method and a system for standardizing a hemodynamics measurement result and a non-transitory computer-readable recording medium. According to one aspect of the present disclosure, provided is a method for standardizing a measurement result obtained from a device for monitoring hemodynamics, the method comprising the steps of: capturing an image of a subject wearing a monitoring device; defining a photogrammetric coordinate system on the captured image, and converting a preset local coordinate system on the monitoring device into the photogrammetric coordinate system; and converting the photogrammetric coordinate system into a standard coordinate system which is based on a standard space.

Abstract: The present invention relates to an apparatus for eliminating motion artifacts and a method thereof, and the method for eliminating motion artifacts includes steps of receiving a PPG signal and three-axis (X-axis, Y-axis, and Z-axis) acceleration signals measured from an examinee, extracting the PPG signal and the three-axis acceleration signals by a period of a predetermined unit of time and filtering the signals at a preset bandwidth, Fourier-transforming the PPG signal and the three-axis acceleration signals corresponding to the extracted period, arranging power spectra of the X-axis, Y-axis, and Z-axis in ascending order of value of average power spectrum by calculating an average power of each frequency domain of the three-axis accelerations, and extracting a final power spectrum of the PPG signal by sequentially eliminating power spectra of the X, Y, and Z-axis accelerations from the power spectrum of the PPG signal in an order of arrangement.

Abstract: A bioamplifier for analyzing electroencephalogram (EEG) signals is disclosed. The bioamplifier includes an input terminal for receiving an EEG signal from a plurality of sensors coupled to a user. The bioamplifier also includes an analogue-to-digital converter arranged to receive the EEG signal from the input terminal and convert the EEG signal to a digital EEG signal. A data processing apparatus within the bioamplifier is arranged to receive the digital EEG signal from the analogue-to-digital converter and programmed to process, in real time the digital EEG signal using a first machine learning model to generate a cleaned EEG signal having a higher signal-to-noise ratio than the digital EEG signal. The bioamplifier further includes a power source to provide electrical power to the analogue-to-digital converter and the data processing apparatus. The bioamplifier includes a housing that contains the analogue-to-digital converter, the data processing apparatus, the power source, and the sensor input.

Abstract: A method for analysing physiological measurement values of a user is proposed. The method comprises at least one data acquisition step, wherein, during the data acquisition step, physiological measurement values of the user are acquired at different measurement times and stored in a measurement data record; at least one pattern selection step, wherein, during the pattern selection step, measurement values acquired during one comparison time interval are selected as at least one comparison pattern; and at least one pattern recognition step, wherein, during the pattern recognition step, patterns corresponding to the comparison pattern are sought after in the measurement data record.

Abstract: The present disclosure relates to devices, systems, methods and computer program products for continuously monitoring, diagnosing and providing treatment assistance to patients using sensor devices, location-sensitive and power-sensitive communication systems, analytical engines, and remote systems. The method of non-invasively measuring multiple physiological parameters in a patient includes collecting photoplethysmograph (PPG) signal data from a wearable sensor device, applying one or more filters to correct the signal data and extracting a plurality of features from the corrected data to determine values for blood glucose, blood pressure, SpO2, respiration rate, and pulse rate of the patient. An alert may be automatically sent to one or more computing devices when the value falls outside a custom computed threshold range for the patient.

Abstract: The present disclosure relates to devices, systems, methods and computer program products for continuously monitoring, diagnosing and providing treatment assistance to patients using sensor devices, location-sensitive and power-sensitive communication systems, analytical engines, and remote systems. The method of non-invasively measuring multiple physiological parameters in a patient includes collecting photoplethysmograph (PPG) signal data from a wearable sensor device, applying one or more filters to correct the signal data and extracting a plurality of features from the corrected data to determine values for blood glucose, blood pressure, SpO2, respiration rate, and pulse rate of the patient. An alert may be automatically sent to one or more computing devices when the value falls outside a custom computed threshold range for the patient.

Abstract: This disclosure provides systems, methods and apparatus for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor. The system may include a display device with at least one input device. In response to movement of or along the input device, the display device may change a glucose data output parameter and update an output of the display device using the changed output parameter.

Abstract: An analyte monitoring system including an analyte sensor, a transceiver, and a display device. The transceiver may be configured to (i) receive measurement information from the analyte sensor, (ii) calculate an analyte concentrations using at least the measurement information, and (iii) convey the calculated analyte concentration. The display device may be configured to (i) receive the analyte concentration from the transceiver, (ii) receive one or more user selections for font or display-related settings, and (iii) display the received analyte concentration using default font or display-related settings that are different than the one or more user selections. The display device may be configured to compare the one or more received user selections to font or display-related criteria and display the received analyte concentration using the different default font or display-related settings in response to determining that the one or more received user selections do not meet the criteria.

Abstract: Disclosed herein are systems and methods for computing a 3D conjugate gaze adjusted length (CGAL) using 3D scans. The measurements for determining CGAL are measured on a clipping plane generated from the 3D CT scans. Acute ischemic strokes (AIS) is determined if the CGAL is greater than 0.28 with high specificity.

Abstract: The present disclosure provides a decomposition method based on basis material combination. In the present disclosure, a scanned object is divided into a plurality of regions, the basis material combinations used in each of the divided regions are different each other, and the scanned object is re-divided according to the re-determined equivalent atomic number of its each point until the change on decomposition coefficient meets certain conditions. Thereby, a decomposition method based on dynamic basis material combinations is realized, which reduces a decomposition error caused by improper selection of the basis material combination and improves the accuracy of the decomposition and substance identification of the multi-energy CT.

Abstract: The method of performing CT imaging by injecting the contrast medium into the object includes: setting a region of interest (ROI) in a scout image of the object; acquiring X-ray projection images by detecting X-rays that have passed through the ROI; determining a difference between pixel values of at least one first X-ray projection image acquired before an injection of the contrast medium into the ROI and pixel values of at least one second X-ray projection image acquired after the injection of the contrast medium into the ROI; and determining whether to initiate a diagnostic CT scan by comparing the difference with a threshold.

Abstract: A medical device system has a medical device interface configured to download data from an implanted medical device. Memory stores electrode location identification rules and display definitions. Each of the display definitions correspond to possible electrode placement locations of the implanted medical device. Processing circuitry is configured to compare the downloaded data from the implanted medical device to the electrode location identification rules to identify one or more actual electrode placement locations of the possible electrode placement locations of the implanted medical device. A user output interface is in communication with the processing circuitry. The processing circuitry is configured to cause the output to display the one or more actual electrode placement locations.

Abstract: A radiation detection device includes: a radiation detection panel; a housing in which the radiation detection panel is housed; a support member that is disposed between a surface of the radiation detection panel on a side opposite to a radiation incidence side and an inner surface of the housing; a plurality of columnar first protruding portions that are formed on a surface of the support member on an opposite side to a surface of the support member on a side of the radiation detection panel; and a second protruding portion that is formed at other region of the surface of the support member on the opposite side than regions of the surface of the support member on the opposite side at which the first protruding portions are formed as defined herein.

Abstract: A wheel alignment guide that provides a visual indication of the desired placement of an apparatus. The wheel alignment guide includes a body having an opening disposed therein. The wheel alignment guide is configured to surround a portion of the apparatus, such as a wheel, via the opening. In addition, the wheel alignment guide is adapted to rest on a ground surface, being held in place via a charge, such as an electrostatic charge created by static cling vinyl. A wheel of a medical device is disposed within the opening of the wheel alignment guide after a desired position of the medical device is selected. If the medical device is moved during a medical procedure, the medical device may be repositioned due to the placement of the wheel alignment guide. Accordingly, the wheel alignment guide eliminates the need for inefficient markers and potentially-dangerous adhesives, particularly in an operating room.

Abstract: A position adjustment device for a flat panel detector comprising: a guide that is provided on a surface side of the flat panel detector and can be measured by an optical device; and a fixing member configured to fix the guide to one of a side of the flat panel detector of a position adjustment unit and a side of a support portion for supporting the flat panel detector, the position adjustment unit being provided between the flat panel detector and the support portion.

Abstract: The present disclosure is directed to a method and device for generating anatomical labels for a physiological tree structure. The method may include receiving a 3D model and a 3D skeleton line of the physiological tree structure. The 3D model is restructured based on medical image data of the physiological tree structure acquired by an imaging device. The method further includes selecting at least one level from extracting geometrical features from a pool of selectable levels. The method also includes extracting, by a processor, geometrical features from the 3D model of the physiological tree structure along the 3D skeleton line at the selected at least one level. The method also includes generating, by the processor, anatomical labels for the physiological tree structure using a trained learning network based on the extracted geometrical features.

Abstract: A radiological imaging device that includes a source that emits radiation that passes through at least part of a patient, the radiation defining, a central axis of propagation; and a receiving device that receives the radiation and is arranged on the opposite side of the patient with respect to the source. The receiving device includes a first detector to detect radiation when performing at least one of tomography and fluoroscopy, a second detector to detect radiation when performing at least one of radiography and tomography; and a movement apparatus arranged to displace the first and second detectors with respect to the source. The movement apparatus provides a first active configuration in which the radiation hits the first detector and a second active configuration in which the radiation hits the second detector.

Abstract: A system and related method for signal processing. Interferometric projection data reconstructed into one or more images for a spatial distribution of a physical property of an imaged object. The interferometric projection data is derived from signals acquired by an X-ray detector (D), said signals caused by X-ray radiation after interaction of said X-ray radiation with an interferometer and with the object (OB) to be imaged, said interferometer (IF) having an inter-grating distance. The reconstructor (RECON) configured to perform, based on the projection data and a forward signal model, a reconstruction operation for one or more images in an image domain of a spatial distribution of at least one physical property of said object (OB) including a refractive index, wherein the reconstructor is configured to perform in the reconstruction operation a scaling operation based on the inter-grating distance of the interferometer and/or on a distance of a location in said image domain from said interferometer (IF).

Abstract: The present disclosure directs to a system and method for image processing. The method for image processing comprises acquiring a plurality of original computed tomography (CT) images of a spine of a subject; generating CT value images of the spine of the subject by processing the plurality of original CT images. The method further includes identifying an optimal sagittal image in which a centerline of the spine is located based on the CT value images. The method further includes identifying the centerline of the spine within the optimal sagittal image. The method further includes identifying a center point and a direction of at least one intervertebral disc along the centerline of the spine. The method still further includes reconstructing an image of the at least one intervertebral disc based on the center point and the direction of the at least one intervertebral disc.

Abstract: A method is disclosed for registration on setting an alignment of an instrument relative to an object during a processing or treatment of the object by the instrument. A working image is registered to a planning image. The working image is recorded in a viewing direction that is selected dependent upon relevant degrees of freedom of the instrument such that the relevant degrees of freedom are the degrees of freedom with the greater registration accuracy. In addition, a robot system is provided which is configured for carrying out the method.

Abstract: A three-dimensional image data record of an examination object is reconstructed from two-dimensional projection images recorded with a biplanar x-ray device. The biplanar x-ray device has two recording arrangements of x-ray emitter and x-ray detector pairs measuring projections displaced by an angle relative to one another. The projection images are simultaneous pairs of projection images recorded at the same time with the different recording arrangements. For the image-based, in particular rigid, registration of the recording arrangements with respect to one another for at least one part, preferably all, of the simultaneous pairs, a degree of consistency based on a redundancy in the projection data of the projection images is determined. A determination of the registration parameters describing the registration of the recording arrangements is carried out by minimizing a consistency metric determined by totaling the degrees of consistency in an optimization method.

Abstract: Exemplary embodiments of the present invention provide a CT imaging method of coronary artery and a computer-readable storage medium, the method comprising: generating and outputting a global optimal phase image of a coronary artery; and generating and outputting a local optimal phase image of a particular trunk of the coronary artery based on a trunk selection command.

Abstract: Method and systems are provided for automatically generating a volume model of correction data for an X-ray based medical imaging device. A plurality of X-ray images is recorded of a body region of a patient to be examined from different positions in each case. The plurality of X-ray images is used to generate a first volume model of the body region. Image artifacts are corrected in the first volume model using the plurality of X-ray images and thus a corrected volume model is generated. The corrected volume model is used to determine a contour of an artifact volume affected by image artifacts in the first volume model and the contour of the artifact volume is defined as a volume model of correction data. The volume model of correction data is stored on a data medium and/or output via an interface.

Abstract: A method for operating a cardiac CT imaging system (200) in coronary CT with prospective electrocardiography-triggering of the imaging system (200) is proposed. The method comprises the steps of determining a plurality of R-peak times (ti) from a dataset of electrocardiography data, determining a variability of a heart rate by statistically analyzing the determined R-peak times and automatically adjusting an acquisition time period (?Tac) of the CT imaging system (200) for acquiring projection data based on the determined variability of the heart rate.

Abstract: A method for calibrating a medical imaging device in terms of an image acquisition geometry, a method for performing a two-dimensional-three-dimensional registration based on corresponding calibration data, and a corresponding system are provided. Multiple images of a phantom are acquired using the imaging device in different positions of the phantom. A corresponding motion of the phantom from one position to a respective next position is tracked by a tracking device to keep continuous track of a spatial relation between the phantom and the imaging device. The medical imaging device is then calibrated based on the acquired images, corresponding recorded poses of the imaging device, and the tracked motion of the phantom.

Abstract: Among other things, one or more techniques and/or systems for calibration of a radiation system to compute a gain correction(s) are provided. A calibration procedure is performed during which a portion of the detector array is shadowed by an object, causing the detector array to be non-uniformly exposed to radiation. A portion of a projection generated from the calibration procedure and indicative of radiation that did not traverse the object is separated from a portion of the projection indicative of radiation that did traverse the object, and a gain correction(s) is computed from the portion of the projection indicative of radiation that did not traverse the object (e.g., and is thus indicative of radiation that merely traversed air).

Abstract: An X-ray apparatus includes an X-ray radiator configured to radiate X-rays to an object and a controller configured to acquire orientation information indicating an orientation of the X-ray radiator and motion information indicating a movement of an X-ray detector configured to detect the X-rays radiated by the X-ray radiator and select the X-ray detector based on the orientation information and the motion information.

Abstract: A stethoscope according to exemplary embodiments of the inventive concept includes a chestpiece for examining a patient by contacting him on the body, a microphone unit for receiving a doctor's voice, a first headset unit connected to the doctor's ears, and a second headset unit connected to the patient's ears, and a guiding unit guiding the chestpiece and the microphone unit to be each connected to at least one of the first headset unit and the second headset unit. Such the composition of the stethoscope enables the patient to listen to the doctor's voice as well as the auscultation sound gathered through the chestpiece, selectively.

Abstract: A stethoscope according to exemplary embodiments of the inventive concept includes a chestpiece for auscultating a patient, a first headset unit enabling a doctor to listen to auscultation sound auscultated by the chestpiece, a second headset unit enabling a patient to listen to the auscultation sound, and a connection unit for connecting the chestpiece, the first headset unit, and the second headset unit with each other and guiding the auscultation sound to the first headset unit and the second headset unit. Such the structure enables for a patient to listen to the auscultation sound as well as for a doctor.

Abstract: Various embodiments of the inventions of the present disclosure provide a combination of feature-based approach and deep learning approach for distinguishing between normal heart sounds and abnormal heart sounds. A feature-based classifier (60) is applied to a phonocardiogram (PCG) signal to obtain a feature-based abnormality classification of the heart sounds represented by the PCG signal and a deep learning classifier (70) is also applied to the PCG signal to obtain a deep learning abnormality classification of the heart sounds represented by the PCG signal. A final decision analyzer (80) is applied to the feature-based abnormality classification and the deep learning abnormality classification of the heart sounds represented by the PCG signal to determine a final abnormality classification decision of the PCG signal.

Abstract: The present invention provides a technique for estimating a blood flow velocity gradient in the vicinity of a blood vessel wall surface with high accuracy under various blood flow conditions.

Abstract: Systems and techniques for real-time, transcranial monitoring of safe blood-brain barrier opening include determining an approach angle for targeted blood-brain barrier opening proximate a predetermined region in a brain of a patient, and positioning an ultrasound transducer to generate a focused ultrasound signal at the determined approach angle to the predetermined region in the brain.