Abstract: The present invention relates to methods and kits or articles of manufacture related thereto that may find use, inter alia, in assessing responsiveness of cancers to MUC16 antagonists by monitoring HE4 expression. In some embodiments, the methods include measuring the level of expression of HE4 in a sample from a subject; comparing the level of expression of HE4 in the sample with the level of expression of HE4 in a sample previously obtained from the subject; and, optionally, administering to the subject a therapeutically effective amount of a MUC16 antagonist.

Abstract: This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.

Abstract: The present invention provides an antibody or a functional fragment thereof that specifically binds to PCSK9 with high affinity, also provides a nucleic acid molecule encoding the antibody of the invention or the functional fragment thereof, for expressing an expression vector and a host cell of the antibody or the functional fragment thereof, and also provides a method for producing the antibody or the functional fragment thereof. The present invention provides that the antibody or the functional fragment thereof is used for treating diseases such as dyslipidemia.

Abstract: The present invention provides an antibody that specifically binds to human aggrecanase, and inhibits enzymatic activity of the human aggrecanase. In one embodiment, aggrecanase is ADAMTS4. In one embodiment, the antibody recognizes a particular epitope in human ADAMTS4, and inhibits not only aggrecanase activity of human ADAMTS4 but also aggrecanase activity of human ADAMTS5. In addition, the present invention also provides use of said antibody in the prophylaxis or treatment of the progression of arthritis.

Abstract: The present disclosure provides monoclonal antibodies against Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9), which can block the binding of PCSK9 to LDL receptor, and therefore lower the level LDL-C. The antibodies of disclosure provide very potent agents for the treatment of multiple CVDs.

Abstract: The present invention concerns a method for preparing antigen binding proteins with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.

Abstract: This invention relates to site-specific integration and expression of recombinant proteins in eukaryotic cells. In particular, the invention includes compositions and methods for improved expression of antigen-binding proteins including monospecific and bispecifc antibodies in eukaryotic cells, particularly Chinese hamster (Cricetulus griseus) cell lines, by employing multiple expression-enhancing locus.

Abstract: The present invention provides crosslinked carboxymethylcellulose having high elastic modulus coupled with high absorbance capacity when swollen in simulated gastric fluid/water (1:8) and simulated intestinal fluids. The invention further provides methods of making the crosslinked carboxymethylcellulose, compositions comprising the crosslinked carboxymethylcellulose and methods of using the crosslinked carboxymethylcellulose, for example, for treating overweight or obesity or for enhancing glycemic control.

Abstract: The present invention provides a conjugated diene-based polymer containing at least one conjugated diene monomer, wherein 40% or more of the end thereof has an amino group and an amide group, and the indicator b* value of yellowness, as measured with a colorimetric color difference meter, is 15 or less.

Abstract: A modified conjugated diene-based polymer, and more particularly, a modified conjugated diene-based polymer having a unimodal molecular weight distribution curve measured by gel permeation chromatography (GPC), molecular weight distribution (PDI; MWD) of less than 1.7, and a Si content of 100 ppm or more based on weight, and including a repeating unit derived from an aromatic vinyl monomer in an amount of greater than 0 wt % and less than 15 wt %, and a rubber composition including the same.

Abstract: A method according to the present invention for producing water absorbent resin powder is a method for producing water absorbent resin having a surface cross-linked structure, and includes: a polymerization step in which an unsaturated monomer aqueous solution is polymerized; a drying step in which a hydrogel cross-linked polymer obtained in the polymerization step is dried; a surface treatment step in which the hydrogel cross-linked polymer or a dried hydrogel cross-linked polymer is subjected to a surface treatment; and a sorting step, carried out after the drying step, in which a foreign matter included in a water absorbent resin is color-sorted from the water absorbent resin entirely or partially. As a result, it is possible to obtain a water absorbent resin which has high properties and is less likely to be colored. In this way, there is provided the water absorbent resin powder production method in which the color sorting technique is used to remove foreign matters from the water absorbent resin.

Abstract: The present invention relates to an emulsifying initiator and, more specifically, provides: an emulsifying initiator comprising a surfactant part, an initiator part, and vinyl monomer-derived repeating unit, the surfactant part comprising an organic acid-based monomer-derived repeating unit, and the initiator part including a peroxide-based monomer-derived repeating unit; and a thermoplastic resin composition comprising the same.

Abstract: A photoinitiator of Formula I includes a benzophenone moiety, a nitrogen-containing moiety (NCM) covalently bonded to the benzophenone moiety, and an unsaturated polymerizable moiety (PM) covalently bonded to the nitrogen-containing moiety. The unsaturated polymerizable moiety includes an acrylate group or a methacrylate group.

Abstract: Disclosed herein are ethylene-based polymers generally characterized by a density from 0.89 to 0.93 g/cm3, a ratio of Mw/Mn from 3 to 6.5, a Mz from 200,000 to 650,000 g/mol, a CY-a parameter at 190° C. from 0.2 to 0.4, and a reverse short chain branching distribution. The ATREF profile of these polymers can have a high temperature peak from 92 to 102° C., and a low temperature peak from 18 to 36° C. less than that of the high temperature peak. These polymers can have comparable physical properties to that of a metallocene-catalyzed LLDPE, but with improved processability, shear thinning, and melt strength, and can be used in blown film and other end-use applications.

Abstract: A metallocene catalyst compound can comprise a structure represented by formula (F-MC) below comprising a first cyclopentadienyl ring with carbon atoms directly connected with R1, R2, R4, and R5, and a second cyclopentadienyl ring with carbon atoms directly connected with R10, R11, R12, and R13, and a bridging group (BG) directly connecting the first and second cyclopentadienyl rings A catalyst system can include the metallocene compound, a non-coordinating anion type activator comprising a supported alumoxane or aluminum alkyl, and optionally a scavenger. A process for making a polymeric product can comprise: contacting a C2-C22 alpha-olefin feed with the catalyst system to obtain a polymerization reaction mixture; and obtaining a polymer product from the polymerization reaction mixture. A polymer product can be made by the process to exhibit at least an Mn from 7000 g/mol to 70000 g/mol and a PDI from 4.1 to 9.0.

Abstract: The present invention relates to a novel ligand compound, a transition metal compound and a catalyst composition including the same. The novel ligand compound and the transition metal compound of the present invention may be useful as a catalyst of polymerization reaction for preparing an olefin-based polymer having a low density. In addition, an olefin polymer which is polymerized using the catalyst composition including the transition metal compound may be used for the manufacture of a product having low melt index (MI) and high molecular weight.

Abstract: Provided is a collection of polymer beads, wherein the volume distribution expressed as a function of bead diameter comprises (A1) a first peak having a maximum of PM1 at diameter PD1 and having full width at half maximum of 75 ?m or less, (A2) a second peak having a maximum of PM2 at diameter PD2 and having full width at half maximum of 75 ?m or less; and (B1) a valley having a minimum value of VM1 at a diameter between PD1 and PD2, wherein VM1 is less than 0.25*PM1 and VM1 is also less than 0.25*PM2. wherein the polymer beads comprise polymerized units of one or more monofunctional vinyl monomer and one or more multifunctional vinyl monomer.

Abstract: The present invention provides a hydrophilic substrate including a hydrophilic polymer layer having a smooth surface and formed of a special polymer (hydrophilic polymer). Included is a hydrophilic substrate including on its surface a hydrophilic polymer layer formed of a hydrophilic polymer having a number average molecular weight of 40,000 or more.

Abstract: Provided herein are sulfated compounds that are useful as high refractive index monomers for optical and other applications and methods for producing the same. The sulfated compounds are liquid at room temperature and exhibit good miscibility with other monomers. They are branched and can act as crosslinking agents, increasing the rigidity of the resulting polymers. They have low molecular weights and are useful in combinations with higher viscosity oligomers or crystalline monomers and to generate curable compositions. Also provided herein are high refractive index curable compositions produced from the sulfated compounds suitable for the production optical articles, including for coatings, gratings, and other surface features. Further provided are high refractive index nanocomposite materials made from the sulfated compounds and curable compositions. Also provided herein are articles and optical devices incorporating the curable compositions and nanocomposites described herein.

Abstract: Vulcanizates with desirable properties can be obtained from compounds incorporating polymers that include hydroxyl group-containing aryl functionalities. The functionalities can be incorporated by using any or all of appropriate initiators, monomers and terminating compounds. Such polymers exhibit excellent interactivity with both conventional and non-conventional fillers.

Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.

Abstract: An overlay film-forming composition used to cause phase separation to a block copolymer-containing layer formed on a substrate, the composition including: (A) a copolymer that includes (a) a unit structure derived from maleimide structure and a unit structure derived from styrene structure; and (B) an ether compound having 8-16 carbon atoms as a solvent. The overlay film-forming composition exhibits good solubility with respect to a hydrophobic solvent, and is able to induce vertical alignment of a block copolymer without causing dissolution, swelling, and the like of the block copolymer-containing layer formed on the substrate.

Abstract: The present invention relates to an energy curable aqueous composition (X) comprising (a) Water; (b) At least a water-insoluble ethylenically unsaturated compound (A); (c) At least one (meth)acrylic polymer (B1) containing ionic functional groups that are at least partly neutralized by a neutralizing agent (C) and/or at least one (meth)acrylic hybrid (B2) containing ionic functional groups that are at least partly neutralized by a neutralizing agent (C); and (d) At least one nonionic emulsifier (D) comprising alternating polyalkylene oxide segments, said nonionic emulsifier (D) having an HLB value of at least 4.5. Materials of the invention are suitable for the preparation of inks, overprint varnishes or coating compositions.

Abstract: A composition for film formation includes a polymer and a solvent. The polymer includes a first repeating unit, a second repeating unit, a third repeating unit, and a structural unit on at least one end of a main chain of the polymer. The first repeating unit includes a crosslinkable group. The second repeating unit differs from the first repeating unit. The third repeating unit differs from the first repeating unit and has higher polarity than polarity of the second repeating unit. The structural unit includes an interacting group capable of interacting with Si—OH, Si—H or Si—N.

Abstract: An object of the present invention is to provide an acrylic resin powder suitable for hot melt adhesives which dissolves in polyol components such as polyalkylene glycols faster than conventional ones, as well as a resin composition which can be produced with lower energy than conventional ones. The object is achieved by using an acrylic resin powder comprising: a copolymer which contains a methyl methacrylate unit, wherein a volume average particle size of a primary particle is 0.1 to 10 ?m, a volume average particle size of a secondary particle is 20 to 80 ?m, a weight average molecular weight is 10,000 to 500,000, and the acrylic resin powder is soluble in polypropylene glycol having a weight average molecular weight of 1000 under stirring at a concentration of 10% by mass at 60° C. for 60 minutes.

Abstract: A curable composition contains: a cardo skeleton-containing monomer having two or more (meth)acryloyl groups in a molecule; an aromatic ring-containing monofunctional (meth)acrylate monomer; and an acidic phosphate ester, in which the acidic phosphate ester is a compound represented by General Formula (1), and the content of the acidic phosphate ester is 0.003% to 1% by mass with respect to a total mass of the curable composition.

Abstract: A fluorine-containing copolymer comprises, as copolymer units, (A) a polyfluoroalkyl alcohol (meth)acrylic acid derivative represented by the general formula: CnF2n+1(CH2CF2)a(CF2CF2)b(CH2CH2)cOCOCR?CH2 [I] (R: a hydrogen atom or a methyl group, n:1 to 6, a:1 to 4, b:1 to 3, c:1 to 3), (B) a non-fluorine (meth)acrylic acid ester represented by the general formula: CH2?CRCOOR3 [III] (R is a hydrogen atom or a methyl group, and R3 is a C1-C30 linear, branched, or cyclic hydrocarbon group that may contain an oxygen atom); and (C) a functional group-containing (meth)acrylic acid or an ester thereof represented by the following general formula: CH2?CRCOO(H)p(R4Y)q [IV] (R: a hydrogen atom or a methyl group, p, q:0 or 1, p+q:1, R4: a C1-C30 linear, branched, or cyclic hydrocarbon group that may have an oxygen atom, Y: a phosphate group or an epoxy group), wherein the component (C) is copolymerized at a ratio of 0.01 to 5 wt. % in the entire copolymer.

Abstract: The present invention provides a polymerizable composition containing a specific polymerizable compound and a fluorosurfactant having, in its molecule, a pentaerythritol skeleton or a dipentaerythritol skeleton. The invention also provides an optically anisotropic body, a retardation film, an antireflective film, and a liquid crystal display device that are produced using the polymerizable composition of the present invention. The present invention is useful because, when an optically anisotropic body is produced by photo-polymerization of the polymerizable composition, three features including the leveling properties of the surface of the optically anisotropic body, offset onto the substrate, and liquid crystal alignment can be improved simultaneously.

Abstract: A catalytic system based at least on isoprene as preformation monomer, on a metallocene of formula {P(Cp1)(Cp2)Y} and on an organometallic compound as cocatalyst, Y denoting a group comprising a metal atom which is a rare earth metal, Cp1 and Cp2, which are identical or different, being selected from the group consisting of fluorenyl groups, cyclopentadienyl groups and indenyl groups, the groups being substituted or unsubstituted, and P being a group bridging the two Cp1 and Cp2 groups and comprising a silicon or carbon atom, is provided. Such a catalytic system is soluble and exhibits an increased stability of the catalytic activity over time, in particular on storage.

Abstract: Synthesis and characterization of starch based pH-responsive nanoparticles for controlled drug delivery are described. Polymethacrylic acid grafted starch (PMAA-g-St) nanoparticles with various molar ratio of starch to MAA were synthesized by a new one-pot method that enabled simultaneous grafting of PMAA and nanoparticle formation in an aqueous medium. NMR data showed that polysorbate 80 was polymerized into the graft polymer. Nanoparticles were relatively spherical with narrow size distribution and porous surface morphology and exhibited pH-dependent swelling in physiological pH range. The particle size and magnitude of volume phase transition were dependent on PMAA content and formulation parameters such as surfactant levels, cross-linker amount, and total monomer concentration. The results showed that the new pH-responsive nanoparticles possessed useful properties for controlled drug delivery.

Abstract: Provided are a method of preparing a graft copolymer, a graft copolymer, and a thermoplastic resin molded article. The method of preparing a graft copolymer includes 1) adding a conjugated diene-based monomer and performing polymerization to prepare a conjugated diene-based polymer; and 2) adding the conjugated diene-based polymer, an aromatic vinyl monomer, and a vinyl cyan monomer and performing polymerization to prepare a graft copolymer, wherein an emulsifier having an APHA color value of 50 or less and a critical micelle concentration of 1 to 50 g/l is added, so that excellent polymerization stability, colorability, light resistance, and surface clarity are exhibited.

Abstract: A solid catalyst component for polymerization of olefins is disclosed which can produce a polymer having low stickiness (tackiness) of polymer particles, excellent flowability, and favorable particle size distribution. The solid catalyst component for polymerization of olefins includes titanium, magnesium, a halogen atom and an internal electron donor, wherein the solid catalyst component has a multimodal pore volume distribution measured by a mercury intrusion method and has one or more peak tops in each of a pore radius range from 0.002 ?m to 1 ?m and a pore radius range from larger than 1 ?m to 30 ?m or smaller, and a ratio represented by pore volume V1 derived from pores in the radius range from 0.002 ?m to 1 ?m/pore volume V2 derived from pores in the radius range from larger than 1 ?m to 30 ?m or smaller is 0.30 to 0.65.

Abstract: Processes for manufacturing novolacs and resoles from lignin are disclosed. A phenol-aldehyde-lignin dispersion is formed which can then be used to make either a novolac or a resole, depending upon the catalysts used.

Abstract: A process for producing polyurethane foam by reacting at least one polyol component with at least one isocyanate component in the presence of at least one blowing agent and of one or more catalysts that catalyze the isocyanate-polyol and/or isocyanate-water reactions and/or the isocyanate trimerization, wherein the reaction is conducted in the presence of selected polyether-siloxane copolymers, is described.

Abstract: Provided are ophthalmic devices comprised of a reaction product of a composition comprising: (i) a crosslinked substrate network containing covalently bound activatable free radical initiators; and (ii) a grafting composition containing one or more ethylenically unsaturated compounds. Also provided are processes for making ophthalmic devices.

Abstract: Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator; (c) contacting the crosslinked substrate network with a grafting composition containing one or more ethylenically unsaturated compounds, wherein the contacting is conducted under conditions such that the grafting composition penetrates into the crosslinked substrate network; and (d) activating the covalently bound activatable free radical initiator at one or more selective regions of the crossli

Abstract: The present invention relates to a polyisocyanurate foam obtainable by reacting a mixture in the presence of a catalyst and optionally an initiator, comprising or consisting of: A) a polyisocyanate component comprising at least one aliphatic polyisocyanate; B) a component reactive to isocyanate comprising at least one polyol and/or an alcohol and also optionally an amine; C) at least one blowing agent; D) at least one foam stabilizer and E) optionally at least one additive, characterized in that the mixture, upon accompanying use of an isocyanate-reactive component (polyol, alcohol, amine), has an index of at least 200. The invention further relates to a process for producing such a foam and use thereof as an insulating material, as a construction element, as facade insulation, as reactor insulation, as battery insulation, as superheated steam insulation, as insulation for a still, or as weather-resistant insulating material.

Abstract: A method is directed to synthesis of poly(triphenylacrylonitrite)s (PTPANs) comprising polycoupling dibromoarenes, internal diynes, and potassium ferrocyanide, resulting in polycoupled dibromoarenes, internal diynes, and potassium ferrocyanide; and producing poly(triphenylacrylonitrite)s (PTPANs) by catalysis of the polycoupled dibromoarenes, internal diynes, and potassium ferrocyanide with palladium acetate and sodium bicarbonate, wherein the catalysis is allowed to proceed in dimethylacetamide under nitrogen at a prescribed temperature for a prescribed time.

Abstract: Disclosed are a polymer including a structural unit represented by Chemical Formula 1 and a structural unit represented by Chemical Formula 2, an organic layer composition including the polymer, and a method of forming patterns using the organic layer composition. The Chemical Formulae 1 and 2 are the same as defined in the specification.

Abstract: A method of coupling and 5,5-Y-3,3?-difluoro-2,2?-bithiophene to produce wherein X can be any known compound capable of coupling with the Y-difluorothiophene and Y is selected from the group consisting of Br, a stannyl group, a boronic ester and a H.

Abstract: A polymer comprising: In this polymer R1, R2, R3, R4, R5, R6, R7, R8, R9 and Rio are independently selected from H, F, Cl, S, CN, or substituted, unsubstituted, straight-chain, branched, or cyclic alkyls ranging from 1 to 100 carbon atoms. The length of the polymer can range with n from about 1 to about 100,000 repeat units.

Abstract: Provided are: an organic electronic multi-sensor wherein an ionic electrolyte and an organic semiconductor polymer are fused to form a double layer and have a mesh shape; and a method for producing same. The organic electronic multi-sensor provides different, complementary ion and charge transfer pathways depending on the volume ratio of the ionic electrolyte and thus is capable of distinguishing the electrical resistance properties of volatile organic compounds having a wide range of polarities. In addition, the organic electronic multi-sensor senses light of respective wavelengths on the basis of optical signals, converts temperatures to electrical signals according to thermal signals, and thus can sense each environment change.

Abstract: Fiber-reinforced terephthalate-co-4,4?-bibenzoate copolyester behaves like a liquid crystalline polymer, providing fast crystallization, short cycling times, high Tg and Tm, high strength and stiffness, while the viscosity is unexpectedly reduced at a low fiber loading ratio. In an injection molding process, the viscosity of the fiber reinforced copolyester at low fiber loading is reduced by increasing the fiber loading.

Abstract: [Problem] Provided is a polyester resin composition is for obtaining a molded article having excellent mechanical properties and slide properties as well as having heat resistance.

Abstract: An object of the present invention is to provide a liquid crystal polyester resin composition in which satisfactory fluidity and excellent mechanical properties as well as flame retardancy are obtained, and the generation of particles is suppressed, and a molded article composed of the liquid crystal polyester resin composition. The present invention relates to a liquid crystal polyester resin composition containing: 100 parts by mass of a liquid crystal polyester (A) including repeating units represented by the formulas (I) to (III), wherein Ar1 and Ar2 each represent one or more divalent aromatic groups, and p, q and r each represent a composition ratio (mol %) of each repeating unit in the liquid crystal polyester (A) and satisfy the following conditions, 35?p?90, 5?q?30, and 5?r?30; and 1 to 150 parts by mass of a fibrous titanium oxide (C).

Abstract: A process to produce a polyester polymer by polymerization of a cyclic polyester oligomer composition comprising a cyclic polyester oligomer having furanic units in the presence of a plasticizer, as well as the polyester polymer obtained thereby.

Abstract: Provided is a polycarbonate resin, including, as a raw material, a bisphenol A having 100 ppm by mass or less of isopropenylphenol and 250 ppm by mass or less of 2-(2-hydroxyphenyl)-2-(4-hydroxyphenyl)propane, each detected after heating in air at 175° C. for 1 hour.

Abstract: The present invention provides a method for producing a thermoplastic resin by reacting reactants comprising a dihydroxy compound.

Abstract: In one aspect, the present disclosure encompasses polymerization systems for the copolymerization of CO2 and epoxides comprising 1) a catalyst including a metal coordination compound having a permanent ligand set and at least one ligand that is a polymerization initiator, and 2) a chain transfer agent having two or more sites that can initiate polymerization. In a second aspect, the present disclosure encompasses methods for the synthesis of polycarbonate polyols using the inventive polymerization systems. In a third aspect, the present disclosure encompasses polycarbonate polyol compositions characterized in that the polymer chains have a high percentage of —OH end groups and a high percentage of carbonate linkages. The compositions are further characterized in that they contain polymer chains having an embedded polyfunctional moiety linked to a plurality of individual polycarbonate chains.

Abstract: To provide a fluoroether composition and a coating fluid that are able to form a surface layer having water/oil repellency, fingerprint stain removability and lubricity, and being excellent in abrasion resistance and light resistance, and an article having such a surface layer. A fluoroether composition, comprising: a specific compound (1) having a hydrolyzable silyl group at one terminal of a poly(oxyperfluoroalkylene) chain and a specific compound (2) having a plurality of hydrolyzable silyl groups at one terminal of a poly(oxyperfluoroalkylene) chain, wherein, in the fluoroether composition, the content of the compound (1) is from 10 to 90 mol %, to the total content of the compound (1) and the compound (2).