Patents Issued in August 13, 2019
  • Patent number: 10377662
    Abstract: The present invention provides a glass fiber composition, a glass fiber and a composite material therefrom. The glass fiber composition comprises the following components expressed as percentage by weight: 53-64% SiO2, greater than 19% and lower than 25% Al2O3, 0.05-7% Y2O3+La2O3+Gd2O3, not greater than 1% Li2O+Na2O+K2O, 10-24% CaO+MgO+SrO, 1.5-12% CaO, lower than 2% TiO2, lower than 1.5% Fe2O3.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: August 13, 2019
    Assignee: JUSHI GROUP CO., LTD.
    Inventors: Yuqiang Zhang, Guorong Cao, Lin Zhang, Wenzhong Xing, Guijiang Gu
  • Patent number: 10377663
    Abstract: Embodiments of the present invention provides fiberizable glass compositions formed from batch compositions comprising amounts of one or more glassy minerals, including perlite and/or pumice.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: August 13, 2019
    Inventors: Hong Li, James C. Watson
  • Patent number: 10377664
    Abstract: A coated glass article including a glass substrate and a coating deposited over the glass substrate. The coating includes a first inorganic metal oxide layer deposited over a major surface of the glass substrate. A second inorganic metal oxide layer is deposited over the first inorganic metal oxide layer. A third inorganic metal oxide layer is deposited over the second inorganic metal oxide layer. A fourth inorganic metal oxide layer is deposited over the third inorganic metal oxide layer. The coated glass article exhibits a total visible light transmittance (Illuminant C) of 40% or more and a visible light reflectance (Illuminant C) of 30% or more.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: August 13, 2019
    Assignee: Pilkington Group Limited
    Inventor: Srikanth Varanasi
  • Patent number: 10377665
    Abstract: Embodiments of the disclosure provide an apparatus and methods for localized stress modulation for overlay and substrate distortion using electron or ion implantation directly to a glass substrate. In one embodiment, a process for modifying a bulk property of a glass substrate generally includes identifying a stress pattern of a glass substrate, determining doping parameters to correct a defect (e.g., overlay error or substrate distortion) based on the stress pattern, and providing a treatment recipe to a treatment tool, wherein the treatment recipe is formulated according to the doping parameters. The process may further include performing a doping treatment process on the glass substrate using the treatment recipe to correct the overlay error or substrate distortion. In some embodiments, the treatment recipe is determined by comparing the stress pattern with a database library containing data correlating stress changes in glass substrates to various doping parameters.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: August 13, 2019
    Assignee: VARIAN SEMICONDUCTOR EQUIPMENT ASSOCIATES, INC.
    Inventors: Joseph C. Olson, Ludovic Godet, Gary Dickerson
  • Patent number: 10377666
    Abstract: The method includes the steps of functionalizing a polyaryletherketone (PAEK) polymer, and blending the PAEK polymer with water to form a sizing composition. The method may further include the step of applying the sizing composition to a fiber. The method may further include the step of heating the fibers, coated with sizing composition, for example to between 300C-400C. In some methods, the functionalized PAEK polymer comprises functionalized polyetherketoneketone (PEKK). In yet other methods, the functionalized PAEK polymer comprises sulfonated PEKK (sPEKK).
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: August 13, 2019
    Assignee: Oxford Performance Materials, Inc.
    Inventors: Scott DeFelice, Anthony DeCarmine
  • Patent number: 10377667
    Abstract: It has been unexpectedly discovered that the addition of a non-spec natural pozzolan to non-spec fly ash significantly improves the properties of the non-spec fly ash to the extent it can be certified under ASTM C618 and AASHTO 295, as either a Class F or Class C fly ash. Other pozzolans may also be used for this beneficiation process. Many pozzolans are experimentally tested and may be used to beneficiate non-spec fly ash into certifiable Class F fly ash. Additionally, this disclosure provides a method of converting a Class C fly ash to a more valuable Class F fly ash, by utilizing natural pozzolans. This discovery will extend diminishing Class F fly ash supplies and turn non-spec fly ash waste streams into valuable, certified fly ash pozzolan which will protect and enhance concrete, mortars and grouts.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: August 13, 2019
    Assignee: CR Minerals Company, LLC
    Inventors: Joseph Earl Thomas, Richard Douglas Carter, Jeffrey Alexander Whidden
  • Patent number: 10377668
    Abstract: A roadway construction material based on treated drill cuttings, a base or sub-base of a roadway comprising treated drill cuttings and water, and methods of making and using the roadway construction material.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: August 13, 2019
    Assignee: Racional Energy & Environment Company
    Inventor: Ramon Perez Cordoba
  • Patent number: 10377669
    Abstract: A low-density, high-strength concrete composition that is both self-compacting and lightweight, with a low weight-fraction of aggregate to total dry raw materials, and a highly-homogenous distribution of a non-absorptive and closed-cell lightweight aggregate such as glass microspheres or copolymer polymer beads or a combination thereof, and the steps of providing the composition or components. Lightweight concretes formed therefrom have low density, high strength-to-weight ratios, and high R-value. The concrete has strength similar to that ordinarily found in structural lightweight concrete but at an oven-dried density as low as 40 lbs./cu.ft. The concrete, at the density ordinarily found in structural lightweight concrete, has a higher strength and, at the strength ordinarily found in structural lightweight concrete, a lower density. Such strength-to-density ratios range approximately from above 30 cu.ft/sq.in. to above 110 cu.ft/sq.in., with a 28-day compressive strength ranging from about 3400 to 8000 psi.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: August 13, 2019
    Assignee: SEBASTOS TECHNOLOGIES INC.
    Inventors: Randall L. Byrd, Matthew D'Ambrosia
  • Patent number: 10377670
    Abstract: A composition for forming molded mantels, columns and other decorative enhancement to fireplace openings is formed of a mixture of alpha hemihydrate gypsum plaster, cement, filler and milled fiber. By using this composition with water and acrylic binder a mixture is formed which sets and gains strength quickly and is an ideal material for manufacturing architectural and decorative structures. Advantageously, a casted piece can be removed from a mold within two to three hours after casting. The finished product has a desired finish that is similar to a casted gypsum cement, referred to sometimes as a honed finish which can withstand high heat, discoloration and cracking while maintaining suitable strength when exposed to typical temperatures of a fireplace surround in indoor applications.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: August 13, 2019
    Inventor: Alireza Molaei Manesh
  • Patent number: 10377671
    Abstract: Conventional sintering processes convert a portion of cBN to hBN which is softer than cBN which negatively affects functional properties of an alumina composite. The invention is directed to method for making an alumina-cubic boron nitride (Al2O3-cBN) composite that contains substantially no hexagonal boron nitride (hBN) by non-conventional spark plasma sintering of cBN with nano-sized alumina particles. The invention is also directed to Al2O3-cBN/Ni composites, which contain substantially no hBN, and which exhibit superior physical and mechanical properties compared to alumina composites containing higher amounts of hBN.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: August 13, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Abbas Saeed Hakeem, Tahar Laoui, Hafiz Muzammil Irshad, Bilal Anjum Ahmed, Muhammad Ali Ehsan
  • Patent number: 10377672
    Abstract: A method for the production of polygranular graphite bodies including the step of provisioning a mixture including a high-temperature treated anthracite having a high vitrinite content and a petroleum-based needle coke and/or a pitch-based needle coke, and provisioning at least one binder coke precursor. The method also includes the steps of forming a green body from the mixture from the provisioning step, and carbonizing and graphitizing the green body.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: August 13, 2019
    Assignee: Showa Denko Carbon Germany GmbH
    Inventors: Wilhelm Frohs, Rainer Schmitt
  • Patent number: 10377673
    Abstract: A method for producing a ceramic honeycomb structure comprising a ceramic honeycomb body having large numbers of longitudinal cells partitioned by porous cell walls having porosity of 50% or more, and a peripheral wall formed on a peripheral surface of the ceramic honeycomb body, comprising the steps of extruding moldable ceramic material to form a honeycomb-structured ceramic green body; machining a peripheral portion of the green body or a sintered body obtained from the green body to remove part of cell walls in the peripheral portion to obtain a ceramic honeycomb body having longitudinal grooves on a peripheral surface; applying colloidal metal oxide to a peripheral surface of the ceramic honeycomb body and drying it, and then applying a coating material comprising ceramic aggregate having an average particle size of 1 ?m or more to form the peripheral wall.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: August 13, 2019
    Assignee: HITACHI METALS, LTD.
    Inventor: Shunji Okazaki
  • Patent number: 10377674
    Abstract: Disclosed are compositions containing at least 5 wt. % of a silicate based on the total weight of the composition, wherein the silicate is an alkali metal silicate and/or an alkaline earth metal silicate, at least 20 wt. % of one or more calcium oxygenates; and water to 100 wt. %.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: August 13, 2019
    Inventor: Carolyn Dry
  • Patent number: 10377675
    Abstract: The present disclosure provides a method for coating a composite structure, comprising forming a first slurry by combining a first pre-slurry composition with a first carrier fluid, applying the first slurry on a surface of the composite structure, and heating the composite structure to a temperature sufficient to form a base layer on the composite structure. The first pre-slurry composition may comprise a first phosphate glass composition and a low coefficient of thermal expansion material, wherein the low coefficient of thermal expansion material is a material with a coefficient of thermal expansion of less than 10×10?6° C.?1.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: August 13, 2019
    Assignee: GOODRICH CORPORATION
    Inventors: Anthony M. Mazany, Steven A. Poteet
  • Patent number: 10377676
    Abstract: A resin-impregnated boron nitride sintered body having superior thermal conductivity and superior strength, and a resin-impregnated boron nitride sintered body having superior conductivity and small anisotropy of thermal conductivity are provided. A resin-impregnated boron nitride sintered body, including: 30 to 90 volume % of a boron nitride sintered body having boron nitride particles bonded three-dimensionally; and 10 to 70 volume % of a resin; wherein the boron nitride sintered body has a porosity of 10 to 70%; the boron nitride particles of the boron nitride sintered body has an average long diameter of 10 ?m or more; the boron nitride sintered body has a graphitization index by powder X-ray diffractometry is 4.0 or less; and an orientation degree of the boron nitride particles of the boron nitride sintered body by I.O.P is 0.01 to 0.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: August 13, 2019
    Assignee: Denka Company Limited
    Inventors: Koki Ikarashi, Shuhei Nonaka, Toshikatsu Mitsunaga, Hideki Hirotsuru, Mitsuru Shiiba
  • Patent number: 10377677
    Abstract: Generally, the instant disclosure relates to fertilizer compositions and methods of making and using the same. More specifically, the instant disclosure relates to blast suppressant and/or blast resistant ammonium nitrate fertilizer compositions, as well as methods of making and using the same.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: August 13, 2019
    Assignee: Alcoa USA Corp.
    Inventors: Mark L. Weaver, Kyle A. Crum, Judodine Nichols, David F. Iwig, Steven C. Orkis, Gerald E. Carkin, Deniz Gencaga, Stephen P. Sunday, Ian Ross Harrison, John R. Smith, Shannon I. Parks, Mikhail Gershenzon
  • Patent number: 10377678
    Abstract: Disclosed herein are fertilizer compositions with enhanced sulphate release, methods of making the fertilizer compositions and methods of using the fertilizer compositions. The disclosed fertilizer compositions combine elemental sulphur with small amounts (relative to the sulphur) of humic acid to enhance delivery of sulphates to soil. The humic acid is added as a humic additive, which may comprise 40% or more humic acid. In many embodiments, the presence of small amounts of humic additive enhances the release of sulphate from soil containing the fertilizer composition from about 1.5- to 4-fold over fertilizer compositions lacking the humic additive.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: August 13, 2019
    Assignee: TIGER-SUL (CANADA) CO.
    Inventors: Don T. Cherry, Guy Wesley Haun, Steven Azzarello, Richard Valagene
  • Patent number: 10377679
    Abstract: A kitchen waste treatment device in environment-protection-device field comprises a main fermentation barrel comprising a barrel body mounted on supporting brackets and including a feed inlet, a discharge outlet and a material chamber, push plates located within the material chamber to push materials therein to move along barrel body axial direction and further a gas inlet system having gas inlets located at same barrel body end as the discharge outlet and a gas-exhaust system having gas-exhaust ports located at same barrel body end as the feed inlet; a feeding apparatus whose feed end communicates with the feed inlet; and a power apparatus driving the barrel body to rotate around its axis. The gas inlets/gas-exhaust ports communicate with the material chamber. The treatment device has simple compact structure and small occupied area and realizes material horizontal propulsion and repeated rotational-stirring in the barrel body by barrel body rotation, achieving material-degrading-and-fermenting object.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: August 13, 2019
    Assignee: ENVIRONMENTAL PROTECTION SCIENCE AND TECHNOLOGY CO. LTD., XIFU, GUANGDONG
    Inventors: Zongcai Huang, Taiping Zhang, Huageng Hu, Nengwu Zhu, Xinghong Jin, Jian Wang, Tingting Yang, Yi Liu, Manying Chen
  • Patent number: 10377680
    Abstract: Novel polyanionic polymers including families of repeat units, such as maleic, itaconic, and sulfonate repeat units. The polymers are at least tetrapolymers and may be in the acid form or as partial or complete salts. The polymers may be synthesized using free radical initiators in the presence of vanadium compounds. The polymers have a variety of uses, particularly in agricultural contexts.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: August 13, 2019
    Assignee: Verdesian Life Sciences, LLC
    Inventors: John Larry Sanders, Jacob Mazo, Grigory Mazo
  • Patent number: 10377681
    Abstract: The present invention describes a control system for units for the production of 1-butene by the oligomerization of ethylene in the presence of a homogeneous catalyst, in the liquid phase and at the bubble point, which uses a multivariable predictive controller and provides the units with better stability.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: August 13, 2019
    Assignee: AXENS
    Inventors: Jean-Marc Bader, Damien Maintenant
  • Patent number: 10377682
    Abstract: In an aspect, the present disclosure provides a method for the oxidative coupling of methane to generate hydrocarbon compounds containing at least two carbon atoms (C2+ compounds). The method can include mixing a first gas stream comprising methane with a second gas stream comprising oxygen to form a third gas stream comprising methane and oxygen and performing an oxidative coupling of methane (OCM) reaction using the third gas stream to produce a product stream comprising one or more C2+ compounds.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: August 13, 2019
    Assignee: SILURIA TECHNOLOGIES, INC.
    Inventors: Humera A. Rafique, Srinivas Vuddagiri, Guido Radaelli, Jarod McCormick, Suchia Duggal, Joel Cizeron
  • Patent number: 10377683
    Abstract: A process for preparing an alkylaromatics isomerisation catalyst comprising at least 0.01% wt of platinum on a carrier comprising of from 1 to 9 wt % of ZSM-12 and inorganic binder, which process comprises treating the carrier with an impregnation solution comprising base and an anionic platinum complex which impregnation solution has a pH of from 5.5 to 8; and a process for the isomerisation of alkylaromatics with the help of catalyst thus obtained.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: August 13, 2019
    Assignee: SHELL OIL COMPANY
    Inventors: Cristina Nicoleta Nenu, Bart Pelgrim, Ingrid Maria van Vegchel
  • Patent number: 10377684
    Abstract: Processes and apparatuses for isomerizing hydrocarbons are provided. In an embodiment, a process for isomerizing hydrocarbons includes providing a first hydrocarbon feed that includes hydrocarbons having from 5 to 7 carbon atoms. The first hydrocarbon feed is fractionated to produce a first separated stream that includes hydrocarbons having from 5 to 6 carbon atoms and a second separated stream that includes hydrocarbons having 7 carbon atoms. The first separated stream is contacted with a benzene saturation catalyst at benzene saturation conditions to produce an intermediate stream and subsequently isomerized in the presence of a first isomerization catalyst and hydrogen under first isomerization conditions to produce a first isomerized stream. The second separated stream is isomerized in the presence of a second isomerization catalyst and hydrogen under second isomerization conditions that are different from the first isomerization conditions to produce a second isomerized stream.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: August 13, 2019
    Assignee: UOP LLC
    Inventors: Soumendra Mohan Banerjee, Steven C. Gimre
  • Patent number: 10377686
    Abstract: An efficient method for producing 1-chloro-2,3,3,3-tetorafluoropropene from 1,1-dichloro-2,3,3,3-tetrafluoropropene is provided. The method produces 1-chloro-2,3,3,3-tetorafluoropropene by reducing 1,1-dichloro-2,3,3,3-tetrafluoropropene with fewer over-reduced by-products, such as 2,3,3,3-tetrafluoropropene and 1,1,1,2-tetrafluoropropane. In the method, 1,1-dichloro-2,3,3,3-tetrafluoropropene reacts with hydrogen in a gas phase in the presence of a palladium catalyst-carrying carrier, in which a palladium catalyst having a specific surface area of 40 m2/g or less is carried on the carrier.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: August 13, 2019
    Assignee: AGC Inc.
    Inventors: Shingo Nomura, Hidekazu Okamoto, Hirokazu Takagi
  • Patent number: 10377687
    Abstract: Titanium complexes containing at least one catecholate ligand can be desirable active materials for flow batteries and other electrochemical energy storage systems. Such complexes can be formed through reacting a catechol compound with a titanium reagent in an organic solvent, removing a byproduct species, and then obtaining an aqueous phase containing a salt form of the titanium catechol complex, particularly an alkali metal salt form.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: August 13, 2019
    Assignee: Lockheed Martin Energy, LLC
    Inventors: Matthew Millard, John Goeltz
  • Patent number: 10377688
    Abstract: A process for the production of diisopropyl ether from high purity propylene without the need of a propane-propylene fractionation column has been developed. The process involves (1) reacting a high purity propylene feedstock and water to produce isopropyl alcohol in a reactor and reacting the isopropyl alcohol with propylene to produce diisopropyl ether in the presence of an acidic ion exchange resin catalyst and a C4 diluent to generate a reactor effluent stream containing at least water, isopropyl alcohol, diisopropyl ether, propylene, and acid, (2) passing the reactor effluent to an acid removal zone to produce an acid-depleted stream, (3) dividing the acid-depleted stream into two portions, (4) recycling a portion to the reactor (5) purging a portion to prevent propane build-up and (6) recovering product diisopropyl alcohol.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: August 13, 2019
    Assignee: UOP LLC
    Inventor: Steven L. Krupa
  • Patent number: 10377689
    Abstract: Process for preparing polyoxymethylene dimethyl ethers having ?3 oxymethylene units (OMEn?3), comprising the steps: (i) introduction of formaldehyde, methanol and water into a reactor R and reaction to give a reaction mixture containing formaldehyde, water, methylene glycol, polyoxymethylene glycols, methanol, hemiformals, methylal (OMEn=1) and polyoxymethylene dimethyl ethers (OMEn>1); (ii) introduction of the reaction mixture into a reactive distillation column K1 and separation into a low boiler fraction F1 containing formaldehyde, water, methylene glycol, polyoxymethylene glycols, methanol, hemiformals, methylal (OMEn=1) and polyoxymethylene dimethyl ethers having from 2 to 3 oxymethylene units (OMEn=2-3) and a high boiler fraction F2 containing polyoxymethylene dimethyl ethers having more than two oxymethylene units (OMEn?3).
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: August 13, 2019
    Assignee: OME TECHNOLOGIES GMBH
    Inventors: Jakob Burger, Niklas Schmitz, Hans Hasse, Eckhard Stroefer
  • Patent number: 10377690
    Abstract: Disclosed is a method for forming enals from corresponding alehydes in a single enclosed unit such as a divided wall reaction distillation unit. The method of the present invention includes (a) feeding an aldehyde feed stream comprising at least one aldehyde reactant into a reaction zone contained within said single enclosed unit; (b) reacting said at least one aldehyde reactant in said reaction zone in the presence of a catalyst to form an enal-containing reaction zone effluent comprising an enal; (c) purifying said enal-containing reaction zone effluent in a first separation zone within said single enclosed unit to form an enal-rich product mixture and a residual unreacted aldehyde mixture; and (d) collecting from said single enclosed unit at least a portion of said enal-rich product mixture. The method of the present invention results in high enal yields at a markedly reduced capital cost and energy consumption as compared to prior art processes.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: August 13, 2019
    Assignee: Eastman Chemical Company
    Inventors: Scott Allen Owens, Robert Lin, Jody Lee Rodgers
  • Patent number: 10377691
    Abstract: Methods for the production of 2,4-dihydroxybutyrate (2,4-DHB) from erythrose and other four-carbon sugars are disclosed. The improved methods facilitate the production of 2,4-DHB that is a precursor for biorenewable and animal nutrition chemicals among others.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: August 13, 2019
    Assignee: DFI USA, LLC
    Inventors: Jonathan Stapley, David Genders
  • Patent number: 10377692
    Abstract: A photoresist composition comprising a resin which comprises a structural unit derived from a compound having an acid-labile group and which is insoluble or poorly soluble in an alkali aqueous solution but becomes soluble in an alkali aqueous solution by the action of an acid, an acid generator and a compound represented by the formula (I?): wherein R51, R52, R53 and R54 independently each represent a C1-C8 alkyl group, and A11 represents a C3-C36 divalent saturated cyclic hydrocarbon group which can contain one or more heteroatoms and which have one or more substituents or a C6-C20 divalent aromatic hydrocarbon group which can contain one or more heteroatoms and which have one or more substituents.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: August 13, 2019
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Akira Kamabuchi, Yuko Yamashita
  • Patent number: 10377693
    Abstract: The present invention discloses 5-bromo-2-(?-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-bromo-2-(?-hydroxypentyl)benzoic acid sodium salt include: amorphous 5-bromo-2-(?-hydroxypentyl)benzoic acid sodium salt, crystal form A of 5-bromo-2-(?-hydroxypentyl)benzoic acid sodium salt, and crystal form B of 5-bromo-2-(?-hydroxypentyl)benzoic acid sodium salt. The different crystal forms of 5-bromo-2-(?-hydroxypentyl)benzoic acid sodium salt obtained according to the present invention have better stability and water-solubility than the mixed forms of 5-bromo-2-(?-hydroxypentyl)benzoic acid sodium salt, thus is advantageous for pharmaceutical use. Moreover, the different crystal forms of 5-bromo-2-(?-hydroxypentyl)benzoic acid sodium salt possess much better therapeutic effect than 5-bromo-2-(?-hydroxypentyl)benzoic acid potassium salt.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: August 13, 2019
    Assignee: Zhejiang Ausun Pharmaceutical Co., Ltd.
    Inventors: Junbiao Chang, Chuanjun Song
  • Patent number: 10377694
    Abstract: The invention relates to new compounds of the general formula (I): as well as the use thereof in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, in particular), or in the use of cosmetic compositions.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: August 13, 2019
    Assignee: Galderma Research & Development
    Inventor: Thibaud Portal
  • Patent number: 10377695
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: August 13, 2019
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Raveendra Panickar Dhanya, Douglas J. Sheffler, Nicholas D. P. Cosford
  • Patent number: 10377696
    Abstract: An apparatus for separating dimethyl carbonate using pervaporation includes: an atmospheric distillation column and a high pressure distillation column distilling a mixture containing dimethyl carbonate and methanol and separating dimethyl carbonate from the mixture; and a pervaporation membrane module disposed between the atmospheric distillation column and the high pressure distillation column and allowing for permeation of the methanol to separate the methanol from the mixture, thereby reducing heat consumption and a process cost as compared to the case of only using an existing pressure swing distillation method.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: August 13, 2019
    Assignees: POSCO, NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO, RESEARCH INSTITUTE OF INDUSTRIAL SCIENCE & TECHNOLOGY
    Inventors: Joon-Hyun Baik, Jaap Ferdinand Vente, Anatolie Motelica
  • Patent number: 10377697
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: August 13, 2019
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Benjamin Martin, Gerhard Penn, Francesco Venturoni, Thierry Schlama, Thomas Ruch, Thomas Allmendinger, Bernhard Wietfeld, Paolo Filipponi
  • Patent number: 10377698
    Abstract: Diphenethylamine derivatives for use as highly active analgesics, diuretics, anxiolytics, for the treatment of neurodegenerative, psychiatric and neuropsychiatric disorders, and also as anti-itch, anti-addiction, anti-inflammatory, anti-obesity, anti-epileptic, anti-convulsant, anti-seizure, anti-stress, anti-psychotic and anti-depressant medications and their pharmaceutically acceptable salts and easily accessible derivatives thereof (e.g. esters, ethers, amides), processes for their preparation and their application in the manufacture of pharmaceutical products.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: August 13, 2019
    Assignee: University of Innsbruck
    Inventors: Helmut Schmidhammer, Mariana Spetea, Elena Guerrieri
  • Patent number: 10377699
    Abstract: A method for the synthesis of daptomycin or a daptomycin analog is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogs can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues. Daptomycin analogs can include a different fatty acid in the side arm of the daptomycin analog.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: August 13, 2019
    Assignee: The University of Hong Kong
    Inventors: Xuechen Li, Hiu Yung Lam
  • Patent number: 10377700
    Abstract: The present invention discloses a process for recovery of a boronic acid of formula R3—B(OH)2, wherein R3 is selected from the group consisting of C1-C6 linear or branched alkyl, C3-C6 cycloalkyl, and C6 aryl, optionally substituted with a group selected from the group consisting of methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl, t-butyl, and phenyl, comprising admixing the boronic acid with a water-immiscible organic solvent in a weight ratio between the boronic acid and the water-immiscible organic solvent from 1:10 to 1:20, adding an aqueous solution to a final pH of neutral, and partitioning the boronic acid into an organic water-immiscible phase and recovery of the organic water-immiscible phase.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: August 13, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Elisa Battistini, Federica Buonsanti, Daniela Imperio, Luciano Lattuada, Roberta Napolitano
  • Patent number: 10377701
    Abstract: A method of manufacturing 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)-malononitrile ([F-18]FDDNP) utilizes a semi-automated module that is used to perform fluorination, pre-purification, separation, product extraction, and formulation. The method is able to produce [F-18]FDDNP with high yields and ready for human administration under existing FDA regulations, and without the need for hazardous organic solvents such as dichloromethane (DCM), methanol (MeOH), and tetrahydrofuran (THF). The method also improves the speed with which [F-18]FDDNP can be synthesized with the method being able to generate a final product within about 90 to 100 minutes. This synthesis method is easily adaptable to FDA registered and approved automated synthesis systems.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: August 13, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Nagichettiar Satyamurthy, Jie Liu, Jorge R. Barrio
  • Patent number: 10377702
    Abstract: A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: August 13, 2019
    Assignee: SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Chengyuan Liang, Yuzhi Liu, Xingke Ju, Yonghong Tang, Gennian Mao, Qianqian Zhao, Bin Tian, Jian Zha, Chunyang Shi, Yongbo Wang, Huayin Pu, Yanghan Liu
  • Patent number: 10377703
    Abstract: A compound represented by formula (4): can be produced by adding a heterogeneous transition metal catalyst to a solution containing a compound represented by formula (3): obtained by performing a nitration reaction by adding a nitrating agent to a solution containing a compound represented by formula (2): obtained by oxidizing a compound represented by formula (1): with hydrogen peroxide in the presence of sodium tungstate and a saturated C8 carboxylic acid, then adding water to the resultant mixture, and separating the resultant solution.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: August 13, 2019
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Yuta Honda, Yohei Tanaka, Kazuya Ueki
  • Patent number: 10377704
    Abstract: The invention relates to a catalyst comprising an active component based on molybdenum and on potassium and a support based on hydroxyapatite, and also to a process for preparing said catalyst and a process for producing methyl mercaptan in a catalytic process by reaction of carbon monoxide, sulphur and/or hydrogen sulphide and hydrogen, comprising the use of said catalyst.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: August 13, 2019
    Assignee: Arkema France
    Inventors: Georges Fremy, Patrice Barre, Karine Sanchou, Alexia Cordova, Carole Lamonier, Pascal Blanchard
  • Patent number: 10377705
    Abstract: A method for preparing a cationic sulfoxide intermediate having the following formula wherein Ar1 and Ar2 are substituted or unsubstituted aryl groups that are the same or different, includes reacting hydrogen peroxide with (i) a compound having the following formula (2) or sulfonic acid R?SO3H, wherein R? is CH3, CF3, phenyl, toluene, or OH, and (ii) a cationic thioether intermediate having the following formula (4) to obtain the cationic sulfoxide intermediate: wherein R is a substituted or unsubstituted C1-C6 alkyl group; and wherein Ar1 and Ar2 are as defined above and Y is an anion.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: August 13, 2019
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Po-Hsien Ho, Chih-Hsiang Lin, Meng-Hsin Chen, Cheng-Hsing Fan, Hsin-Ching Kao, Yih-Her Chang
  • Patent number: 10377706
    Abstract: According to the present invention, there is provided a method for producing carboxylic acid thioester, comprising reacting a compound represented by the following formula (I), carboxylic acid and thiol in the presence of a catalyst including at least one Group 2 metal compound. The production method is a production method which is simple in reaction operation, which places a small load on the environment and the human body and which enables carboxylic acid thioester to be catalytically obtained at a high yield even at a normal temperature and a normal pressure (25° C., 1 atm). In the formula (I), R1 and R2 each independently represent a hydrocarbon group having 1 to 20 carbon atoms.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: August 13, 2019
    Assignee: Mitsubishi Chemical Corporation
    Inventor: Akihiro Goto
  • Patent number: 10377707
    Abstract: A process for the synthesis of lactams suitable for use in antimicrobial, anti-biofilm bacteriostatic compositions.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: August 13, 2019
    Assignee: CONOPCO INC.
    Inventors: Andrew Martyn Norbury, David William Thornthwaite
  • Patent number: 10377708
    Abstract: The various aspects present inventions provide various crystalline forms of (S)-(?)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same. In various aspects, the inventions also provide methods of resolving racemic amisulpride.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: August 13, 2019
    Assignee: Sunovion Pharmaceuticals Inc.
    Inventors: John R. Snoonian, Harold Scott Wilkinson
  • Patent number: 10377709
    Abstract: Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R1 to R7 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: August 13, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: Koen Vandyck, Geerwin Yvonne Paul Haché, Bart Rudolf Romanie Kesteleyn, Pierre Jean-Marie Bernard Raboisson
  • Patent number: 10377710
    Abstract: The present invention relates to a novel, improved, commercially viable and industrially advantageous process for the preparation of Silodosin of Formula (I), its pharmaceutically acceptable salts or solvates thereof. The invention relates to the preparation of considerably pure Silodosin with high yield.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: August 13, 2019
    Assignee: MANKIND PHARMA LTD.
    Inventors: Kuldeep Singh Gangwar, Anil Kumar, Bhuwan Bhashkar
  • Patent number: 10377711
    Abstract: The present disclosure relates to indole derivatives of the formula (I) which are cannabinoid type 1 receptor modulators and which are useful in the treatment of diseases in which modulation of the receptor is beneficial; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: August 13, 2019
    Assignees: The University Court of the University of Aberdeen, The Governing Council of the University of Toronto
    Inventors: Ruth Ross, Iain Greig, Matteo Zanda, Chih-Chung Tseng
  • Patent number: 10377712
    Abstract: The present invention provides an improved process for preparation of an intermediate of apremilast. The present invention also provides an improved process for preparation of apremilast. This invention also provides novel polymorphs of apremilast. The present invention also provides pharmaceutical compositions of novel polymorphs of apremilast. This invention also provides a process for preparation of novel polymorphs of apremilast, which are cost-effective, robust, and viable at plant scale.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: August 13, 2019
    Assignee: LUPIN LIMITED
    Inventors: Palash Sanphui, Ananda Pundlik Sapdhare, Arunkumar Digambar Patil, Hemraj Mahadeorao Lande, Gurvinder Pal Singh, Puma Chandra Ray, Nandu Baban Bhise, Girij Pal Singh, Mithun Dasharath Surwase, Shantanu Gokuldas Varade, Govind Dnyanoba Ausekar, Radhakrishna Bhikaji Shivdavkar