Patents Issued in August 15, 2019
  • Publication number: 20190246896
    Abstract: Disclosed is a measurement method for determining a value of a visual correction need for near vision of an individual in a natural posture for near vision. A recognizing limit distance is determined so that the individual is able to recognize at least one predetermined symbol farther than the limit distance relatively to the individual and unable to recognize the at least one predetermined symbol closer to the individual than the limit distance. A portable medium displaying the predetermined symbol is displaced in front of the face and eyes of the individual to change a frontal distance between his/her eyes and the portable medium and in which when a recognizing limit distance is detected by the individual, the limit distance is measured and the value of the visual correction need is determined from the measured limit distance, wherein the visual correction need includes an accommodation compensation need.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 15, 2019
    Inventors: Martha HERNANDEZ-CASTANEDA, Konogan BARANTON, John CARRIER
  • Publication number: 20190246897
    Abstract: In certain embodiments, an ophthalmic diagnostic system includes a laser source, a galvanometer, and a system inverting controller (SIC) coupled to the galvanometer. The galvanometer includes one or more optical elements and one or more galvanometer controllers configured to manipulate an orientation of the one or more optical elements to scan the output of the laser source across an ophthalmic target based on galvanometer control signals. The system inverting controller (SIC) is configured to modify input galvanometer control signals based on an estimated transfer function of the galvanometer and provide the modified galvanometer control signals to the galvanometer.
    Type: Application
    Filed: February 4, 2019
    Publication date: August 15, 2019
    Inventor: Jeremy Krisel Berke
  • Publication number: 20190246898
    Abstract: A method for measuring distances and angles in the human eye in a highly sensitive manner in order to insert an intraocular lens having the correct refractive power during a cataract operation. The method is based on low coherence interferometry using the dual beam method, in which the time domain signals are detected using a spatially resolving sensor. The delay line of the interferometric measuring arrangement employed is continuously tuned and the low coherence illumination light source used to illuminate the retina of an eye is periodically modulated in terms of its brightness. The light signals reflected by the retina are captured by a sensor and detected in spatially resolved fashion. The disclosed method is used to measure the eye length of a cataractous eye. Even though the method is provided, in particular, for measuring already cataractous eyes, it can be used, in principle, to measure the axial length of all eyes.
    Type: Application
    Filed: July 14, 2017
    Publication date: August 15, 2019
    Applicants: Carl Zeiss Meditec AG, Carl Zeiss AG
    Inventors: Daniel BUBLITZ, Roland BERGNER, Manfred DICK
  • Publication number: 20190246899
    Abstract: An illumination system for producing an illumination pattern for measuring the cornea of an eye and, in particular, for determining the topography thereof and in so doing facilitating distance-independent measurements. The illumination system according to the invention for determining the topography of the cornea of an eye includes an illumination unit and a unit for producing an illumination pattern, wherein the illumination unit includes a plurality of illumination modules. A lens array which produces a spatially distributed, collimated illumination pattern is used as a unit for producing an illumination pattern. The illumination system produces an illumination pattern, by which the topography of the cornea of an eye can be determined. Here, the illumination system is designed as a compact module, and so it can be easily combined with other measurement systems, without colliding with the beam paths thereof.
    Type: Application
    Filed: August 31, 2017
    Publication date: August 15, 2019
    Applicant: Carl Zeiss Meditec AG
    Inventors: Beate BÖHME, Rico FUCHS, Günter RUDOLPH
  • Publication number: 20190246900
    Abstract: This present invention comprises a Galilean tele-microscope lens assembly configured to attach to the front of a binocular indirect ophthalmoscope (BIO) either permanently or by means of a clip or other suitable detachable mechanism, and to enhance an image of a patient's ocular fundus produced by a condensing lens hand-held by the examiner, at their arm's length, in front of the patient's eye. The lens assembly of the present invention magnifies the examiner's view of the hand-held condensing lens itself, and thus magnifies the fundus image produced by the hand-held condensing lens, enabling improved appreciation of finer details in an examination. In addition to improving BIO examinations in general, the present invention is especially advantageous for patients who have disabilities, are wheelchair bound, are children, or are patients of “mission” based ophthalmoscopy services provided in developing, “emerging economy” countries where other examination equipment may not be available.
    Type: Application
    Filed: February 12, 2019
    Publication date: August 15, 2019
    Applicant: The Research Foundation for SUNY
    Inventor: David M. Krumholz
  • Publication number: 20190246901
    Abstract: Methods and devices for implanting an intra-ocular pressure sensor within an eye of a patient are provided herein. Methods include penetrating a conjunctiva and sclera with a distal tip of a fluid-filled syringe and positioning the pressure sensor within a vitreous body of the eye by injecting the sensor device through the distal tip. The sensor device may be stabilized by one or more anchoring members engaged with the sclera so that the pressure sensor of the sensor device remains within the vitreous body. Methods further include advancing a sensor device having a distal penetrating tip through at least a portion of the sclera to position the sensor within the vitreous body and extracting of the sensor devices described herein by proximally retracting the sensor device using an extraction feature of the sensor device.
    Type: Application
    Filed: January 15, 2019
    Publication date: August 15, 2019
    Inventors: Ariel Cao, Enrique Malaret
  • Publication number: 20190246902
    Abstract: Devices, systems and methods are disclosed which relate to remotely monitoring the health of an individual. The individual wears a health monitoring device, with an attached strap, capable of sensing characteristics of the individual. These characteristics may include voice level and tone, movements, blood pressure, temperature, etc. The device allows individuals to constantly monitor their health without having to physically visit a doctor or other health care professional. Wireless communication, for instance with an Internet Protocol Television (IPTV) set-top box, allows measurements to be made and evaluated by a computerized healthcare service provider. For a more accurate evaluation, measurements are sent over the INTERNET to a service. The device communicates with services in order to diagnose the individual based upon the characteristics.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Applicant: AT&T Intellectual Property I, L.P.
    Inventors: Hisao Chang, Lusheng Ji, Bernard S. Renger
  • Publication number: 20190246903
    Abstract: A method for imaging the brain of a living patient includes creating and displaying an unconstrained 3D virtual reality image of the brain of the living patient based on a plurality of 3D images captured by magnetic resonance imaging (MRI). An administration of a drug is simulated into brain tissue. The simulation includes displaying a simulated diffusion of the drug in 3D VR image of the brain; displaying simulated brain tissue uptake of the drug in the 3D VR image of the brain; displaying a simulated stimulation of individual neurons in the 3D VR image of the brain; and analyzing a simulated activity of the individual neurons based on at least one predetermined property of the drug. The method further includes determining a brain treatment protocol based at least in part on the simulated administration of the drug into the brain.
    Type: Application
    Filed: February 14, 2018
    Publication date: August 15, 2019
    Inventor: Yaakov SETTY
  • Publication number: 20190246904
    Abstract: A stroke diagnosis and prognosis prediction system includes: an image acquisition unit configured so as to receive a plurality of images including at least a part of a human brain; an image alignment unit for aligning the plurality of images on the basis of a standard brain image; a lesion area detection and mapping unit for respectively detecting lesion areas from the plurality of images, and mapping the detected lesion areas so as to generate one mapping image; a matching and correction unit, which scales a mapping image so as to match the same to the standard brain image and performs image correction on the mapping image; a three-dimensional image generation unit storing the mapping image in a three-dimensional data space, thereby generating a three-dimensional lesion image; and a stroke diagnosis unit for diagnosing a stroke on the basis of the three-dimensional lesion image.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 15, 2019
    Applicants: JLK INSPECTION, DONGGUK UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
    Inventors: Dong Eog KIM, Won Tae KIM, Shin Uk KANG, Myung Jae LEE, Dong-min KIM
  • Publication number: 20190246905
    Abstract: Systems and methods for acquiring images of a sample are provided. According to an aspect of the invention, a system includes a first light source that emits first light having a first wavelength as a temporally continuous beam; a second light source that emits second light having a second wavelength as a temporally modulated beam; and a scanning mirror that raster scans the first light across a sample during a raster scan period, and projects a structured light pattern of the second light onto the sample during the raster scan period. A first image of the sample is generated from at least a portion of the first light that is backscattered from the sample during the raster scan period, and a second image of the sample is generated from at least a portion of the second light that is backscattered from the sample during the raster scan period.
    Type: Application
    Filed: January 23, 2019
    Publication date: August 15, 2019
    Applicant: Verily Life Sciences LLC
    Inventors: Chinmay Belthangady, James Polans, Daniele Piponi, Eden Rephaeli
  • Publication number: 20190246906
    Abstract: In an optical coherence tomography apparatus that generates a full-color optical coherence tomographic image, an image generation unit includes a correction processing unit that calculates an attenuation related value related to attenuation of signal intensity of the interference light of three R, G, and B colors in a first depth region and corrects the signal intensity of a second depth region deeper than the first depth region according to the attenuation related value to calculate a correction signal for the interference light and generates a full-color optical coherence tomographic image using the correction signals calculated for each of R, G, and B.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 15, 2019
    Applicant: FUJIFILM Corporation
    Inventors: Sohichiro NAKAMURA, Heijiro Hirayama, Takafumi Noguchi
  • Publication number: 20190246907
    Abstract: The present application discloses methods, devices, and systems for generating spatially-resolved quantification of cross-linking in cartilage based on Raman scattering of excitation light. The examples presented demonstrate that the method provides a discriminating power sufficient to distinguish early onset of osteo-arthritis even before a patient is symptomatic.
    Type: Application
    Filed: June 10, 2017
    Publication date: August 15, 2019
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Sinisa VUKELIC, Gerard A. ATESHIAN
  • Publication number: 20190246908
    Abstract: According to an embodiment of the present disclosure, there is provided a laser spectroscopy-based independent device, including: a spectrometer configured to measure a spectrum of generated light which is generated by a laser projected onto a sample; and a disease analysis module configured to determine whether there is lesion tissue by applying a lesion tissue detection learning model to a result of non-discrete spectrum measurement, which is measured by the spectrometer, wherein the spectrometer is configured to measure spectra of all generated light that is generated from a time when the laser is projected onto the sample.
    Type: Application
    Filed: August 13, 2018
    Publication date: August 15, 2019
    Inventors: Sung Hyun PYUN, Wanki MIN
  • Publication number: 20190246909
    Abstract: A method of non-invasively detecting and purging bacterial cells using a modified photoacoustic in vivo flow cytometer device is described herein. In particular, a method of detecting bacterial cells by analyzing photoacoustic pulses emitted in response to laser pulses from a pulsed laser source and/or selectively destroying the detected bacterial cells using a non-linear photothermal response induced by a high-energy laser pulse is described herein.
    Type: Application
    Filed: February 11, 2019
    Publication date: August 15, 2019
    Inventors: Mark S. Smeltzer, Vladimir Zharov, Ekaterina Galanzha
  • Publication number: 20190246910
    Abstract: The present invention provides an imaging-type heart rate monitoring device and method thereof. It acquires the human image information tracks the target area in the human image information, and extracts the target image in the target area. It transforms the human image information through the first frequency domain transform. It filters the residual noise of the continuous wavelet transform information. It rebuilds the residual noise filtered information by the continuous wavelet transform. It transforms the continuous wavelet transform rebuilt information by the Fourier transform. It obtains a heart rate value through the second frequency domain transformed information.
    Type: Application
    Filed: July 19, 2018
    Publication date: August 15, 2019
    Applicant: National Chiao Tung University
    Inventors: Bing-Fei Wu, Po-Wei Huang, Tsong-Yang Tsou, Tzu-Min Lin, Meng-Liang Chung
  • Publication number: 20190246911
    Abstract: A method for determining an arteriovascular condition of a subject having an arterial blood flow is shown. The method involves determining a temporal progression of an instantaneous blood flow condition of the arterial blood flow as well as deriving a slew rate of the temporal progression during an increase of the temporal progression. In addition, an arteriovascular condition indicator device is shown, which comprises: an input for receiving an input signal representing an instantaneous arterial blood flow condition of a subject and a slew rate monitor connected to the input. A corresponding control device for providing an activation signal is also shown. The control device comprises a maximum detector connected to the slew rate monitor. A method for stimulation of arteriogenesis is also shown, wherein a temporal progression of an instantaneous blood flow condition is monitored, a slew rate of the temporal progression is derived, and the maximum of the slew rate is determined.
    Type: Application
    Filed: April 9, 2019
    Publication date: August 15, 2019
    Inventors: Ivo BUSCHMANN, Axel PRIES, Ferdinand LENOBLE
  • Publication number: 20190246912
    Abstract: An implantable device for sensing intravascular pressure, the device comprising a bulk acoustic wave (BAW) resonator arranged to be deflected by changes in intravascular fluid pressure to provide a pressure dependent sensing signal and an acoustic reflector arranged to separate the BAW resonator from the intravascular fluid and to mediate pressure from the intravascular fluid to the BAW resonator wherein the acoustic reflector comprises a layer structure arranged to provide a series of transitions in acoustic impedance between the intravascular fluid and the BAW resonator.
    Type: Application
    Filed: November 2, 2017
    Publication date: August 15, 2019
    Applicants: IP2IPO INNOVATIONS LIMITED, IP2IPO INNOVATIONS LIMITED
    Inventors: Mohammad Reza Bahmanyar, Christopher Neil McLeod
  • Publication number: 20190246913
    Abstract: The present disclosure relates to a method for detecting and/or quantitatively assessing cardiac dyssynchrony of a subject based on at least one medical imaging scan showing at least part of the myocardium of the subject's heart, in particular mechanical cardiac dyssynchrony. The medical imaging scan may provide a plurality of values of a predefined myocardial deformation parameter of said part of the myocardium. In a preferred embodiment the method comprises the steps of 1) determining a myocardial deformation deviation between pairs of myocardial deformation parameter values selected from the myocardium of substantially opposite parts of a cardiac chamber, and 2) calculating the cardiac dyssynchrony of the subject based on said myocardial deformation deviation.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 15, 2019
    Inventor: Tomas Zaremba
  • Publication number: 20190246914
    Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.
    Type: Application
    Filed: February 6, 2019
    Publication date: August 15, 2019
    Inventors: Alexandra Elena Constantin, Scott M. Belliveau, Naresh C. Bhavaraju, Jennifer Blackwell, Eric Cohen, Basab Dattaray, Anna Leigh Davis, Rian Draeger, Arturo Garcia, John Michael Gray, Hari Hampapuram, Nathaniel David Heintzmann, Lauren Hruby Jepson, Matthew Lawrence Johnson, Apurv Ullas Kamath, Katherine Yerre Koehler, Phil Mayou, Patrick Wile McBride, Michael Robert Mensinger, Sumitaka Mikami, Andrew Attila Pal, Nicholas Polytaridis, Philip Thomas Pupa, Eli Reihman, Peter C. Simpson, Tomas C. Walker, Daniel Justin Wiedeback, Subrai Girish Pai, Matthew T. Vogel
  • Publication number: 20190246915
    Abstract: The invention concerns a system and method for reconstructing a physiological signal of an artery/tissue/vein system of an organ in a surface space. Said method is implemented by processing means of a processing unit of a functional imaging analysis system, and comprises a step for reconstructing said physiological signal from a piece of experimental data of a region of interest comprising an elementary volume—called a voxel—of said organ and a surface mesh describing said surface space. The invention differs from known methods in particular in terms of the high accuracy of same and the robustness thereof to noise.
    Type: Application
    Filed: September 8, 2017
    Publication date: August 15, 2019
    Applicants: Olea Medical, Universite d'Aix-Marseille, Centre National de la Recherche Scientifique
    Inventors: Lucie THIEBAUT LONJARET, Christine BAKHOUS, Olivier COULON, Sylvain TAKERKART
  • Publication number: 20190246916
    Abstract: Systems and methods for remotely monitoring blood flow that include an endovascular prosthesis. The endovascular prosthesis includes a conduit forming a lumen within a surrounding wall having an inner surface and an outer surface. A monitoring device is disposed on the wall forming the lumen. The monitoring device comprises a sensor element configured to detect a physical event and to generate an electrical parameter shift in response to the physical event. An antenna portion is configured to receive a first oscillating electrical signal from an interrogator device and to transmit a second oscillating electrical signal to the interrogator device. The second oscillating electrical signal is modulated by the electrical parameter shift.
    Type: Application
    Filed: July 12, 2017
    Publication date: August 15, 2019
    Applicant: Graftworx, Inc.
    Inventors: David KURAGUNTLA, Samit Kumar GUPTA, Lilip LAU, Anthony F. FLANNERY
  • Publication number: 20190246917
    Abstract: The present invention provides an image based blood pressure monitoring method, comprising: acquiring at least a human image information of at least a human skin area; according to the human image information to locate at least a ROI; extracting the human image information of the ROI, and calculate; filtering the average value of the human image information; monitoring the filtered signal; calculating an image pulse transmit time of the filtered signal, and calculating an inter-beat interval of the filtered signal; and employ the specific prediction model, to calculate a systolic pressure value and a diastolic pressure value.
    Type: Application
    Filed: July 20, 2018
    Publication date: August 15, 2019
    Applicant: National Chiao Tung University
    Inventors: Bing-Fei Wu, Po-Wei Huang, Chun-Hao Lin, Meng-Liang Chung, Tzu-Min Lin
  • Publication number: 20190246918
    Abstract: An apparatus (6) connectable to a medical instrument (5) is configured to ascertain a figure of merit (22) based on a shape deviation between the temporal measurement signals (11,13) after normalization, wherein the temporal measurement signals (11,12) are received form sensors (56,57) integrated into the medical instrument (5). A system comprising the apparatus and a method of ascertaining the figure of merit are further presented.
    Type: Application
    Filed: July 14, 2017
    Publication date: August 15, 2019
    Applicant: Koninklijke Philips N.V.
    Inventor: Hendrikus Bernardus VAN DEN BRINK
  • Publication number: 20190246919
    Abstract: The invention provides a method and a system for correcting pulse transit time (PTT) associated with arterial blood pressure or a blood pressure value (BP) calculated by the PTT, which are able to correct abnormal change of the PTT of a subject caused by cardiovascular diseases or various medical interventions or abnormal change of the BP calculated from the PTT. The invention real-timely detects pulse wave signals from the proximal end and distal end in each cardiac cycle, calculates the PTT and extracts one or more feature data and feature factors from the pulse wave signals; based on one or more feature factors, determines a cardiovascular state of the subject and a change in the state, and obtains one or more correction variables in each cardiac cycle; obtains a correction matrix based on the correction variable, and corrects the PTT associated with BP or the BP calculated by the PTT.
    Type: Application
    Filed: April 22, 2019
    Publication date: August 15, 2019
    Applicant: ZHEJIANG MAILIAN MEDICAL EQUIPMENT CO., LTD
    Inventors: Yan CHEN, Yu CHEN
  • Publication number: 20190246920
    Abstract: An intelligent examination device includes a processor, an electrode apparatus, and a stereoscopic image capturing apparatus. The electrode apparatus is connected to the processor and includes first and second electrodes. When a detection loop is between the first electrode and the second electrode, measurement information is transmitted to the processor. The stereoscopic image capturing apparatus transmits a biological appearance stereoscopic image to the processor. The processor obtains biological appearance information according to the biological appearance stereoscopic image, and calculates physiological information according to the biological appearance information and the measurement information. The intelligent examination device uses the collaboration of the electrode apparatus and the stereoscopic image capturing apparatus and can achieve the effect of multiple examination devices by a simple mechanism.
    Type: Application
    Filed: February 13, 2019
    Publication date: August 15, 2019
    Inventor: Han-Wei Zhang
  • Publication number: 20190246921
    Abstract: The present invention provides a contactless-type sport training monitor method, comprising: selecting at least an image database to recognize a plurality of expressions in the image database; making pre-processing for the plurality of expressions: using a convolutional neural network as a feature point extraction model; acquiring a human image; tracking a first target region and a second target region in the human image; making chrominance-based rPPG trace extraction; using the deep level model to compare the second target region image; and to calculate a post-exercise heart rate recovery achievement ratio, to judge the Rating of Perceived Exertion, and judging whether the human body is under overtraining status or not.
    Type: Application
    Filed: July 20, 2018
    Publication date: August 15, 2019
    Applicant: National Chiao Tung University
    Inventors: Bing-Fei Wu, Chun-Hsien Lin, Po-Wei Huang, Tzu-Min Lin, Meng-Liang Chung
  • Publication number: 20190246922
    Abstract: A biological information measurement device adapted to measure biological information of a living body includes a board having a first surface and a second surface adapted to form two surfaces of the board with the first surface, a circuit element disposed on the first surface, and adapted to execute a predetermined process, and a sensor section disposed on the second surface, and adapted to detect the biological information, and the sensor section has a light emitter adapted to irradiate the living body with light, a light receiver adapted to receive reflected light reflected by the living body, and a sealing material having a light transmissive property, having contact with the living body, and adapted to seal the light emitter and the light receiver on the board.
    Type: Application
    Filed: February 14, 2019
    Publication date: August 15, 2019
    Applicant: SEIKO EPSON CORPORATION
    Inventors: Atsushi MATSUO, Kazuyuki KANO, Yoshiaki MATSUMOTO, Hiroki KOBAYASHI
  • Publication number: 20190246923
    Abstract: A method for preparing microsensors (e.g., microelectrodes) suitable for use in electrophysiology and electrochemistry studies in vitro and in vivo is described. The method can involve preparing a polymeric resin-insulated electron conducting fiber using a 3D printed mold comprising one or more channels, wherein each of the channels includes a tapered section. An electron conducting fiber partially enclosed within a metal or glass support can be laid in a channel; and a polymeric resin can be poured into the channel and cured, providing a polymer-insulated electron conducting fiber having a tapered section in proximity to a polymer-free electroactive tip area. For example, the method can be used to provide a polyimide-insulated carbon fiber microsensor. The mold can be used for the batch fabrication of the microsensors. The microsensors themselves, the molds for making the microsensors, and methods of using the microsensors are also described.
    Type: Application
    Filed: August 16, 2017
    Publication date: August 15, 2019
    Inventors: Cheng YANG, B. Jill VENTON, Elefterios TRIKANTZOPOULOS
  • Publication number: 20190246924
    Abstract: The invention relates to a patient monitoring apparatus (6) comprising a first measuring unit (7) for performing an electrical measurement of a physiological property like an electrocardiogram measurement providing a heart rate, while an electrical treatment procedure is not performed, and a second measuring unit (8) for performing a non-electrical measurement of the physiological property like an optical photoplethysmogram measurement providing the heartrate. A data communication unit (10) is adapted to receive a treatment indication, which indicates that the electrical treatment procedure will be performed, from an electrical treatment apparatus (12), and a controller (9) is adapted to control the patient monitoring apparatus such that the measurement of the physiological property is switched from the electrical measurement to the non-electrical measurement, after the treatment indication has been received.
    Type: Application
    Filed: September 28, 2017
    Publication date: August 15, 2019
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventor: Thomas VOLLMER
  • Publication number: 20190246925
    Abstract: This specification describes a method of visually displaying electrocardiogram data in a compressed manner on the display screen wherein rhythmic information is visible and a method of categorizing zones of the electrocardiogram data.
    Type: Application
    Filed: November 3, 2017
    Publication date: August 15, 2019
    Inventors: Pierre FECTEAU, Germain ÉTHIER
  • Publication number: 20190246926
    Abstract: The invention relates to a device for detecting atrial fibrillation of a subject, comprising a member comprising —mechanical connection means to wearably connect the member to a subject; —the member further comprising an optical sensor arranged to measure a signal representing a blood perfusion parameter of the subject; the member comprising the optical sensor and mechanical connection means at such relative positions that when the mechanical connection means connect the member to the subject, the optica! sensor operatively faces the subject. The device is arranged to detect atrial fibrillation of the subject based on the signal measured by the optical sensor.
    Type: Application
    Filed: June 22, 2017
    Publication date: August 15, 2019
    Inventors: Nathalie Virag, Soren Aasmul, Catherine Chassard, Richard Cornelussen, Gerard Hill, Robert Leinders, Mirko De Melis, Raphael Schneider, Vasiliki Spyropoulou
  • Publication number: 20190246927
    Abstract: An apparatus comprises a data processing unit, which causes the apparatus to: receive at least two electroencephalographic signals of a brain of a person; form a first information about at least one of the following: phase-to-phase coupling between at least two electroencephalographic signals, phase-to-amplitude coupling between at least two electroencephalographic signals and amplitude-to-phase coupling between at least two electroencephalographic signals, the first information being related to slow waves having frequencies at or lower than 1 Hz; normalize the first information; and output information about the normalized first information.
    Type: Application
    Filed: February 14, 2018
    Publication date: August 15, 2019
    Inventors: Eero VÄYRYNEN, Jukka KORTELAINEN
  • Publication number: 20190246928
    Abstract: The present invention relates to a physiological monitoring device. Some embodiments of the invention allow for long-term monitoring of physiological signals. Further embodiments may also allow for the monitoring of secondary signals such as motion.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Inventors: Timothy J. Bahney, Hung H. Ho, Shena H. Park, Genaro S. Sepulveda, Mark J. Day, Yuriko Tamura
  • Publication number: 20190246929
    Abstract: Systems and methods for processing neural signals are provided. A neural data analysis system may comprise a feature extraction module configured to extract a plurality of features from neural signal waveforms obtained by an implanted neural interface probe with a plurality of channels or electrodes, and transmit the extracted features as a plurality of discrete outputs. The neural data analysis system may also comprise a feature-event coalescence module configured to receive the plurality of discrete outputs from the feature extraction module, and construct a model-based inference of bioelectric activity based on feature event statistics, prior knowledge of bioelectric signals, and/or a behavioral model of the feature extraction module.
    Type: Application
    Filed: February 13, 2019
    Publication date: August 15, 2019
    Inventors: Mattew Angle, Edmund Huber, Robert Edgington
  • Publication number: 20190246930
    Abstract: Provided are a localization system and method useful in the acquisition and analysis of cardiac information. The localization system and method can be used with systems that perform cardiac mapping, diagnosis and treatment of cardiac abnormalities, as examples, and in the retrieval, processing, and interpretation of such types of information. The localization system and method use high impedance inputs, improved isolation, and relatively high drive currents for pairs of electrodes used to establish a multi-axis coordinate system. The axes can be rotated and scaled to improve localization.
    Type: Application
    Filed: May 3, 2017
    Publication date: August 15, 2019
    Inventors: Min Zhu, Derrick R. Chou, Beatty E. Graydon, Xinwei Shi
  • Publication number: 20190246931
    Abstract: A method for producing an implantable multielectrode array includes providing a substrate carrying conductors each having a section with a constriction. The sections extend mutually parallel in a first direction. A portion of the substrate is removed to form separate first and second substrate parts separated by a gap. Each section extends in the first direction from the first substrate part across the gap to the second substrate part. A first force is exerted on the first substrate part, a second force is exerted on the second substrate part and the sections are heated to generate a fracture of the sections at the constriction. The fracture separates the section into an electrode protruding from the first substrate part and an electrode protruding from the second substrate part. An implantable multielectrode array and a device for manufacturing an implantable multielectrode array are also provided.
    Type: Application
    Filed: January 17, 2019
    Publication date: August 15, 2019
    Inventors: ECKARDT BIHLER, HUBERT ZIMMERMANN
  • Publication number: 20190246932
    Abstract: A patch type electrocardiogram (ECG) sensor including base layer having pad form; flexible printed circuit board (FPCB) layer formed on the base layer and having film form; sensor formed on FPCB layer and including plurality of electrodes configured to acquire ECG signals and plurality of electrode circuit parts which are constituted by circuit patterns and the first ends thereof are individually connected to the plurality of electrodes; main body formed on the FPCB layer and connected to second ends of the plurality of electrode circuit parts to converge the plurality of electrode circuit parts; and adhesive layer formed on FPCB layer such that plurality of electrodes are exposed and configured to attach the sensor to human body, connection part configured to transmit the ECG signals to the outside is installed at and connected to the main body, and main body and the connection part are connected by wire.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 15, 2019
    Inventor: Byung Choo Moon
  • Publication number: 20190246933
    Abstract: Physiological monitoring can be provided through a lightweight wearable monitor that includes two components, a flexible extended wear electrode patch with sewn electrodes and a reusable monitor recorder that removably snaps into a receptacle on the electrode patch. The monitor sits centrally on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline, with its unique narrow “hourglass”-like shape, significantly improves the ability of the wearable monitor to cutaneously sense cardiac electrical potential signals, particularly the P-wave and the QRS interval signals indicating ventricular activity in the ECG waveforms. In particular, the ECG electrodes on the electrode patch are tailored to be positioned axially along the midline of the sternum for capturing action potential propagation in an orientation that corresponds to the aVF lead used in a conventional 12-lead ECG that is used to sense positive or upright P-waves.
    Type: Application
    Filed: April 19, 2019
    Publication date: August 15, 2019
    Inventors: Jason Felix, Jon Mikalson Bishay, Gust H. Bardy
  • Publication number: 20190246934
    Abstract: A method for constructing physiological electrode assembly with integrated flexile wire components is provided. An electrode backing is formed from a stretchable woven textile material, the electrode backing having a proximal electrode backing end and a distal electrode backing end. A set of flexile wires is integrated into the proximal electrode backing end to form a set of electrical contact surfaces shaped to interface with a monitor recorder on a side of proximal electrical backing end opposite the contact side of the proximal electrode backing end. An electrocardiographic electrode is positioned on the contact side of the distal electrode backing end. A further electrocardiographic electrode is positioned on the contact side of the proximal electrode backing end. One of the electrical contact surfaces is connected to the electrocardiographic electrode. Another one of the electrical contact surfaces is connected to the further electrocardiographic electrode.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Inventors: Jason Felix, Jon Mikalson Bishay, Gust H. Bardy
  • Publication number: 20190246935
    Abstract: Medical catheterization is carried out by receiving a plurality of analog bioelectric signals in respective channels and multiplexing the bioelectric signals in respective selection events. The selection events consist of making a first connection with a reference voltage, thereafter breaking the first connection and making a second connection with one of the bioelectric signals. The method is further carried out by outputting the multiplexed bioelectric signals to an analog-to-digital converter.
    Type: Application
    Filed: April 24, 2019
    Publication date: August 15, 2019
    Applicant: BIOSENSE WEBSTER (ISRAEL) LTD.
    Inventors: Assaf Govari, Andres Claudio Altmann, Yaron Ephrath, Oleg Khudish
  • Publication number: 20190246936
    Abstract: A system and method may be provided for associating bio-signal data (e.g. EEG brain scan data) from at least one user with at least one music data item (e.g. song, or piece of music). By associating bio-signal data, or emotions determined therefrom, with music, the system may establish a data store of music associated with emotions. That database may then be leveraged upon determining that a user is feeling a particular emotion through an EEG scan. When a particular emotion is detected in EEG data of a user, the system may then respond based at least partly on the same or similar emotion being associated with one or more music data items in the system. For example, the system may recommend a particular song associated with the same emotion presently being experienced by the user.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 15, 2019
    Inventors: Ariel Stephanie GARTEN, Christopher Allen AIMONE, Trevor COLEMAN, Kapil Jay Mishra VIDYARTHI, Locillo (Lou) GIUSEPPE PINO, Michael Apollo CHABIOR, Paul Harrison BARANOWSKI, Raul Rajiv RUPSINGH, Madeline ASHBY, Paul V. TADICH, Graeme Daniel MOFFAT, Javier Arturo MORENO CAMARGO
  • Publication number: 20190246937
    Abstract: The systems and methods described herein combine both moisture and electromyograph (EMG) sensors in a single wearable garment, along with a suitable output device such as a “smart” mobile device or computer, to provide users with new and useful feedback that can significantly improve incontinence symptoms. The EMG provides feedback to the user specifically regarding the quality of pelvic floor muscle contractions, while the moisture sensor provides feedback about the “end result” of the subjects' incontinence. Each measurement device alone can also provide useful information and feedback to different population groups. Combining these two measurements provides unprecedented data to enhance the subjects' therapy in managing urinary incontinence.
    Type: Application
    Filed: September 27, 2017
    Publication date: August 15, 2019
    Inventors: Jeanne Chow, Carlos Estrada, Michael K. Dempsey
  • Publication number: 20190246938
    Abstract: A quantitative, ultrashort time to echo, contrast-enhanced magnetic resonance imaging technique is provided. The technique can be used to accurately measure contrast agent concentration in the blood, to provide clear, high-definition angiograms, and to measure absolute quantities of cerebral blood volume on a voxel-by-voxel basis.
    Type: Application
    Filed: June 9, 2016
    Publication date: August 15, 2019
    Inventors: Codi GHARAGOUZLOO, Srinivas SRIDHAR
  • Publication number: 20190246939
    Abstract: To provide an operator with operability similar to that of conventional devices with an electromagnetic device that accurately maintains a magnetic field distribution by adjusting the magnetic field for each eigenmode obtained by singular value decomposition. The strength of a unique mode is found from a measurement magnetic field, a current for each unique mode of a negative feedback control according to the magnetic field is calculated and the current is added to each mode to obtain a current for each shim coil, and a coil current is controlled so as to reach the obtained current value. In an interface for an operator, a target for a corrected magnetic field and a magnetic field generated by a shim coil are displayed using a spherical surface harmonic function strength. Due to this configuration, a device which enables accurate magnetic field adjustment while offering operability similar to conventional devices can be provided.
    Type: Application
    Filed: January 26, 2017
    Publication date: August 15, 2019
    Inventor: Mitsushi ABE
  • Publication number: 20190246940
    Abstract: The present invention includes an apparatus and method for external magnetic resonance imaging and spectroscopy of a prostate comprising: one or more radio frequency (RF) coils adapted to externally image the prostate, wherein the one or more RF coils are sized and shaped to fit within the perineum area of a subject allowing the placement of the one or more RF coils on the perineum, wherein the one or more RF coils are positioned perpendicular to the prostate; and a processor connected to the radio frequency (RF) coils adapted to measure at a resonance frequency of a magnetic resonance imaging (MRI) scanner or a spectrophotometer, wherein a signal received by the one or more RF coils is used to generate an image of the prostate during magnetic imaging.
    Type: Application
    Filed: August 30, 2017
    Publication date: August 15, 2019
    Inventors: Robert E. Lenkinski, Alexander Ivanishev, Keith M. Hulsey, Ivan Pedrosa, Neil Rofsky, Daniel Costa
  • Publication number: 20190246941
    Abstract: A medical imaging system including: a microwave antenna array comprising a plurality of microwave antennae which are spaced from one another; an ultrasonic transducer array comprising a plurality of ultrasonic transducers which are spaced from one another and interspersed between the microwave antennae; wherein the plurality of microwave antennae define a transmitting antenna configured to transmit microwave signals so as to illuminate a body part of a patient and define receiving antennae configured to receive the microwave signals following interaction with the body part; and wherein the plurality of ultrasonic transducers define a transmitting transducer configured to transmit ultrasonic waves so as to insonate the body part of the patient and define receiving transducers configured to receive the ultrasonic waves following interaction with the body part; the system further comprising: a processor configured to process the received microwave signals and the received ultrasonic waves and generate an image o
    Type: Application
    Filed: September 29, 2017
    Publication date: August 15, 2019
    Inventors: Peter Romilly Bannister, Chris Frank Bore
  • Publication number: 20190246942
    Abstract: A wearable device for performing a plurality of functions including a first function to measure a body composition parameter of a user wearing the device and one or more second functions requiring an input from the user. The device comprises a first electrode arranged, when the device is worn by a user, to contact the body of the user, a second electrode arranged to be touched by the user, a touch controller arranged to detect when a user touches the second electrode, a body composition parameter measurement device arranged, when the user is in contact with the second electrode, to measure a body impedance of the user by passing a current between the first and second electrodes and detecting a voltage generated between the first and second electrode in response to the current, and to use the measured body impedance to determine a body composition parameter.
    Type: Application
    Filed: August 31, 2017
    Publication date: August 15, 2019
    Inventors: Anastasia Moreva, Brie Betz, Walter Hermsen, Ali Erdi Tugmaner, Nevil Sreedhar, Borja Fernandez Rodriguez
  • Publication number: 20190246943
    Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.
    Type: Application
    Filed: April 23, 2019
    Publication date: August 15, 2019
    Inventors: Andrea Varsavsky, Fei Yu, Michael E. Miller, Ning Yang
  • Publication number: 20190246944
    Abstract: A surgical navigation system comprising a signal receiver communicatively coupled to a primary processor, the primary processor programmed to utilize a sequential Monte Carlo algorithm to calculate changes in three dimensional position of an inertial measurement unit mounted to a surgical tool, the processor communicatively coupled to a first memory storing tool data unique to each of a plurality of surgical tools, and a second memory storing a model data sufficient to construct a three dimensional model of an anatomical feature, the primary processor communicatively coupled to a display providing visual feedback regarding the three dimensional position of the surgical tool with respect to the anatomical feature.
    Type: Application
    Filed: November 6, 2018
    Publication date: August 15, 2019
    Inventor: Mohamed Rashwan Mahfouz
  • Publication number: 20190246945
    Abstract: Devices and methods obtain and use endovascular electrograms (or electrocardiograms/ECGs) in a number of clinical applications and settings. In one embodiment, a method for locating an indwelling medical device within a vasculature of a patient includes identifying a P-wave segment in an endovascular ECG signal associated with the indwelling medical device, then calculating a positive energy value relating to an amount of energy of the P-wave segment above a baseline of the endovascular ECG signal and a negative energy value relating to an amount of energy of the P-wave segment below a baseline of the endovascular ECG signal. A position of the medical device within the vasculature can be determined using at least one of the positive energy value and the negative energy value in a graphical user interface.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 15, 2019
    Inventor: Sorin Grunwald