Abstract: Systems and methods for ultrafast synthetic transmit aperture (“USTA”) ultrasound imaging using coded virtual sources are described. The methods can implement spatially distinct or spatially overlapping sub-apertures with appropriate timing of transmission between the spatially overlapping sub -apertures. The systems and methods described here are capable of increasing signal-to-noise ratio (“SNR”) and spatial resolution to reduce frame rate.

Abstract: For region of interest (ROI) placement in quantitative ultrasound imaging with an ultrasound scanner, the ROI is automatically placed using anatomy detection specific to the quantification, signal processing for clutter, attenuation, or noise, and/or identification of regions of fluid. For quantification, multiple ROIs may be positioned automatically. The automatic placement may improve consistency of measures over time and between sonographers and may provide for better image quality with less influence from undesired signals. As a result, diagnosis and/or treatment may be improved.

Abstract: A method for measuring a viscoelastic parameter of an organ, includes emitting ultrasonic shots by an ultrasonic transducer; receiving by the transducer and recording the reflected ultrasonic signals; determining a viscoelastic parameter of the organ based on the recorded ultrasonic signals. The ultrasonic shots are formed by K groups of shots, separated temporally, K being greater than or equal to 1. Each K group is formed by the repetition, with a rate of PRF2, of MK blocks of ultrasonic shots, MK being greater than or equal to 1; each MK block is composed of N ultrasonic shots, N being greater than or equal to 1, PRF1 being the rate of emission of the N shots when N is chosen greater than 1; the N ultrasonic shots are distributed over P frequencies, P being between 1 and N, at least two ultrasonic shots belonging to two different blocks having different frequencies.

Abstract: A probe for transient elastography includes a probe casing, at least one ultrasound transducer having a symmetry axis, a vibrator located inside the probe casing, a position sensor coupled to the probe casing, the position sensor being arranged to measure the displacement of the probe, wherein the vibrator is arranged to induce a movement of the probe casing along a predefined axis, the predefined axis being the symmetry axis of the ultrasound transducer. The ultrasound transducer is bound to the probe casing with no motion of the ultrasound transducer with respect to the probe casing, and the probe includes a feedback circuit including the position sensor and a control loop and configured to use the displacement of the probe as a feedback signal and to control the movement of the vibrator inside the probe casing and the shape of a low frequency pulse applied by the probe.

Abstract: Rather than trying to automate what an experienced user does, rules designed for processor implementation are used for color flow imaging optimization by an image processor of an ultrasound scanner. By determining a characteristic of a scanned target, a priori information is provided. This a priori information, such as a size of a primary target, is used to select the optimization to be used. Different types of optimization may be used for different characteristics of the primary target. The values for settings may be different for different characteristics.

Abstract: According to one embodiment, an analysis apparatus includes processing circuitry. The processing circuitry configured to generate a harmonic signal and a fundamental wave signal based on a reception signal that is collected by an ultrasound probe, the harmonic signal corresponding to a harmonic component of a reflected wave of a ultrasound generated in the subject, the fundamental wave signal corresponding to a fundamental wave component of the reflected wave, calculate a first index value indicating tissue properties of the subject based on the harmonic signal, and calculate a second index value indicating the tissue properties based on the fundamental wave signal, and display an analysis result based on the first index value and the second index value.

Abstract: Aspects of the technology described herein relate to an ultrasound device including a first die that includes an ultrasonic transducer, a first application-specific integrated circuit (ASIC) that is bonded to the first die and includes a pulser, and a second ASIC in communication with the second ASIC that includes integrated digital receive circuitry. In some embodiments, the first ASIC may be bonded to the second ASIC and the second ASIC may include analog processing circuitry and an analog-to-digital converter. In such embodiments, the second ASIC may include a through-silicon via (TSV) facilitating communication between the first ASIC and the second ASIC. In some embodiments, SERDES circuitry facilitates communication between the first ASIC and the second ASIC and the first ASIC includes analog processing circuitry and an analog-to-digital converter. In some embodiments, the technology node of the first ASIC is different from the technology node of the second ASIC.

Abstract: Aspects of the technology described herein relate to an ultrasound device including a first die that includes an ultrasonic transducer, a first application-specific integrated circuit (ASIC) that is bonded to the first die and includes a pulser, and a second ASIC in communication with the second ASIC that includes integrated digital receive circuitry. In some embodiments, the first ASIC may be bonded to the second ASIC and the second ASIC may include analog processing circuitry and an analog-to-digital converter. In such embodiments, the second ASIC may include a through-silicon via (TSV) facilitating communication between the first ASIC and the second ASIC. In some embodiments, SERDES circuitry facilitates communication between the first ASIC and the second ASIC and the first ASIC includes analog processing circuitry and an analog-to-digital converter. In some embodiments, the technology node of the first ASIC is different from the technology node of the second ASIC.

Abstract: A computing system includes a memory configured to store instructions, and one or more processors configured to execute the instructions to receive data relating to an image or a user, determine a feature from the data, identify a user preference from a user profile, obtain a model, and segment the image based on the feature, the user preference, and the model. The model is generated by determining a historical feature from historical data as an input, determining a desired output, obtaining a preliminary model based on the input and the desired output, determining an actual output of the preliminary model, determining error criteria between the actual output and the desired output, and generating the model by updating the preliminary model based on the error criteria.

Abstract: Aspects of the technology described herein relate to ultrasound data collection using tele-medicine. An instructor electronic device may generate for display an instructor augmented reality interface and receive, on the instructor augmented reality interface, an instruction for moving an ultrasound imaging device. The instructor augmented reality interface may include a video showing the ultrasound imaging device and a superposition of arrows on the video, where each of the arrows corresponds to a possible instruction for moving the ultrasound imaging device. A user electronic device may receive, from the instructor electronic device, an instruction for moving an ultrasound imaging device, and generate for display, on a user augmented reality interface shown on the user electronic device, the instruction for moving the ultrasound imaging device.

Abstract: A wireless intraluminal imaging device and an associated system are provided. In one embodiment, the wireless intraluminal imaging device includes a flexible elongate member including a proximal portion and a distal portion; an ultrasound imaging component coupled to the distal portion of the flexible elongate member; a cable coupled to the ultrasound imaging component and extending along the flexible elongate member; and a wireless communication component coupled to the proximal portion of the flexible elongate member, the wireless communication component in communication with the ultrasound imaging component via the cable. The wireless communication component wirelessly transmits ultrasound echo signals collected by the ultrasound imaging component to an image processing system via a wireless link for image generation at the image processing component.

Abstract: Aspects of the present disclosure relate to a master sonography device configured to determine movement parameters describing movement of a master transducer head by a sonographer, and a slave sonography device, remote from the master sonography device, being configured to move a slave transducer head based on the movement parameters received from the master sonography device. The slave sonography device includes a positioning system that is configured to generate patient parameters describing margins of a patient. Aspects of the present disclosure further relate to a mock patient configured to conform to the margins of the patient based on the patient parameters to mimic the patient at the master sonography device during the sonography examination, such that manipulation of the master transducer head applied against the mock patient controls movement of the slave transducer head applied against the patient.

Abstract: An image processing and analyzing system for ovulation detection includes: an electronic device including a camera portion; a saliva acquisition device including a saliva accommodation portion accommodating saliva of a subject, and a case in which the saliva accommodation portion is located, the case including an entrance, at an end thereof, an entrance through which the saliva accommodation portion enters and exits, and a penetration hole is formed in one surface of the case through which the saliva may be exposed to outside; an ovulation prediction device including a body portion, wherein the electronic device is mounted on one surface and an opening is formed in the surface to allow the camera portion to be positioned in the opening, an insertion unit formed at one side of the body portion to allow the saliva acquisition device to be inserted into a certain depth, and a light source located in the body portion and providing light to the saliva acquisition device; and a controller acquiring a captured image

Abstract: A kit and a method are disclosed for collecting and preparing a biological sample for testing where the sample is to be mixed with a buffer prior to being tested.

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

Abstract: A biopsy device includes a hydraulic drive assembly, a drive mechanism, and a biopsy member. The hydraulic drive assembly includes a chamber housing that defines a proximal chamber, a distal chamber, and a transition chamber that collectively form a continuous passage in the chamber housing. The proximal chamber has a first transverse area and the distal chamber has a second transverse area, with the first transverse area being larger than the second transverse area. A drive piston is located in the proximal chamber and a driven piston is located in the distal chamber. A hydraulic fluid fills a cavity between the drive piston and the driven piston to establish a hydraulic connection between the drive piston and the driven piston. The drive mechanism is connected to the drive piston to move the drive piston in the proximal cylinder. The biopsy member is connected to the driven piston.

Abstract: A device for closing an opening in tissue includes a shaft having a proximal end, a distal end, and a channel disposed between the proximal and distal ends. A pair of pins are disposed within the channel and cooperate with a slidable and axially movable foot. The foot extends distally from the channel with a flexible guidebody extending from a distal foot end of the foot.

Abstract: A First Responder device for treating blood flow from a deep wound or a bodily cavity comprises an inflatable balloon, a first chamber accommodating a liquid arranged for inflating the balloon, a second chamber accommodating a cooling agent capable of dissolving in the liquid when coming in contact therewith, thereby lowering the temperature, a rupturable seal between the first and second chambers, and a structure for forcing the liquid out of the first chamber into the inflatable balloon, and for rupturing the rupturable seal.

Abstract: A medical device for sealing a defect in a body includes a wire frame that includes a plurality of wires that form a first occluding member and a second occluding member, the wire frame including a defect-occupying portion disposed between the first occluding member and the second occluding member. The defect-occupying portion is adapted to fill a wide range of potential defect sizes, such that no more than five devices of a range of sizes are required to effectively seal a range of nominal defect sizes of approximately 8 to 35 mm.

Abstract: A device for occluding a vasculature of a patient including a micrograft having an absorbent polymeric structure with a lumen of transporting blood. The micrograft has a series of peaks and valleys formed by crimping. The occluding device is sufficiently small and flexible to be tracked on a guidewire and/or pushed through a microcatheter to a site within the vasculature of the patient. Delivery systems for delivering the micrografts are also disclosed.

Abstract: A device for removing organs from a human or animal body has a tube, said device comprising a proximal and a distal end where the proximal end is provided for partly introducing into the body, and whereby the distal end of the tube is connectable to a suction air source and the proximal end of the tube is designed to come into suction contact with the organ. The device also comprises a tubular casing, which surrounds some sections of the tube, and has a proximal end and a distal end that is connected to the tube; a handling device arranged on the tube and designed to open or expand the proximal end of the tubular casing and to guide or place it around the organ; a closing device to close the proximal end of the tubular casing, and a comminuting device provided in the tube.

Abstract: A probe having a contact force sensor is inserted into a cardiac chamber and an image of the blood pool is generated. A portion of the blood pool is removed from the image to retain a remaining portion of the blood pool. A determination is made that the distal segment of the probe is within the remaining portion of the blood pool, and responsively to the determination the contact force sensor is manually zeroed.

Abstract: Shapeable articles with structured elements and kits including one or more of the shapeable articles. The shapeable articles described herein have a variety of uses including use as surgical retractors for moving and/or restraining tissue and/or organs to improve access to a surgical site. The shapeable articles described herein can be shaped or manipulated into three-dimensional shapes without the use of tools and hold those shapes after removal of the force required to achieve the shape.

Abstract: A surgical access device includes a seal assembly having a seal housing and a gimbal mount disposed within the seal housing, the seal housing defining a central longitudinal axis and having a longitudinal passage for receiving at least one surgical object therethrough and the gimbal mount adapted for angular movement relative to the central longitudinal axis. The surgical access device also includes a bellows configured to engage at least a portion of the gimbal mount, the bellows dimensioned and adapted to establish a biasing relationship with the gimbal mount, such that the bellows overcomes a frictional relationship between the gimbal mount and the seal housing, thereby moving the gimbal mount towards a position in which the passage of the gimbal mount is aligned with the central longitudinal axis. The bellows is configured to be attached to a side wall of the seal housing.

Abstract: An orbital tissue retractor 10 for use in a surgical operation in the region of an eye socket, comprises an orbital tissue retractor body 12 and a handle 14 extending therefrom for manipulation of the tissue retractor body by a surgeon. The tissue retractor body comprises a channel formation 16 defining a channel 17. The channel formation 16 has a pair of spaced side wall sections 24 which define concave curved ocular abutment formations 26 which conform to an anatomical curvature of the ocular globe for abutment with the ocular globe N. The tissue retractor body has open proximal end 22 and an open distal end 20. The tissue retractor body tapers from the proximal end to the distal end, with a portion of the channel formation at the distal end being curved so as to accommodate and cradle the optic nerve therein. The retractor body has a curved base wall section 28 conforming to an anatomical curvature of the orbit.

Abstract: Devices, systems and/or methods for fixating soft tissue to bone are provided. In one embodiment, a repair device for fixating soft tissue to bone with a bone anchor includes a soft tissue anchor and one or more flexible members. The soft tissue anchor includes a base with multiple legs extending from the base. The one or more flexible members are coupled to the base and configured to extend from the base to the bone anchor with a fixed length. With this arrangement, the fixed length of the one or more flexible members is configured to maintain a fixed distance between the soft tissue anchor and the bone anchor such that, as the bone anchor is seated into bone, the one or more flexible members pulls the soft tissue anchor down against the soft tissue to fixate the soft tissue to the bone.

Abstract: The technology includes an anchor assembly for tissue repair having an open helical coil sleeve and a tip structure. The tip structure includes an aperture for passing a suture and a suture capture member for capturing a suture. The technology also includes an anchor driver for installing an anchor into bone. The anchor driver includes an outer shaft and a sleeve advancement member for advancing the sleeve as well as an inner shaft and a suture capture advancement member for advancing the suture capture member. The technology also includes a system for tissue repair having an anchor assembly and an anchor driver for installing the anchor assembly into bone.

Abstract: An apparatus includes a flexible fixation member having a body with a longitudinal extent and a width, the body defining a plurality of openings through the body, each of the plurality of openings formed substantially cross wise through the width of the body, and a suture having two terminal ends, the suture being interwoven through each of the plurality of openings in the body of the fixation member such that multiple portions of the fixation member are slidably coupled to the suture and configurable to form a cluster within a surgical site.

Abstract: A system for fastening soft tissue to bone includes a bone screw having a threaded shaft and a screw head having an underside with malleable protuberances that project toward a distal end of the threaded shaft. A fixation plate is coupled with the threaded shaft. The fixation plate has a proximal face that opposes the underside of the screw head, a distal face that faces away from the underside of the screw head, an outer peripheral edge that extends between the proximal and distal faces, a central opening for receiving the threaded shaft, and protrusions spaced from one another around the outer peripheral edge that extend distally beyond the distal face of the fixation plate. The system includes an insertion tool having a handle and a tubular shaft extending distally from the handle.

Abstract: A method for coupling tissue includes aligning a guide tool on an outer surface of a first tissue; forming a bore in the first tissue aligned with the guide tool; deploying a non-slip suture construct through the guide tool and into the bore; adjusting a saddle along a flexible member to a position adjacent to a soft anchor, wherein the saddle prevents the flexible member from slideably moving relative to the soft anchor; and threading the flexible member through a second tissue to secure the second tissue to the first tissue.

Abstract: A suture construct includes, inter alia, a sheath and a flexible strand threaded through the sheath to configure the sheath in a circular or oblong shape. The suture construct may be utilized in various tissue reconstruction procedures. The suture construct can be connected to a second suture construct to form a surgical assembly.

Abstract: A tissue anchor deployment device includes a needle having a slotted portion including a longitudinal slot that runs from a distal end of the needle and a suture having a first coil portion including a plurality of turns that wrap around a first portion of the slotted portion of the needle, a second coil portion including a plurality of turns that wrap around a second portion slotted portion of the needle that is proximal to the first portion of the slotted portion of the needle, and an internal coupling portion that runs within the first coil portion and the second coil portion and couples a distal end of the first coil portion to a proximal end of the second coil portion.

Abstract: A subcutaneous wound closure assembly having a closure apparatus, an insertion assembly and a retracting structure. The closure apparatus includes a substrate having a central axis and an outer perimeter. Radial ribs having micro needles extend therefrom. The insertion assembly includes an outer sheath and an applicator. Retracting structures in the form of sting members are coupled to the closure apparatus. A method of use is likewise set forth.

Abstract: A surgical instrument has an interlocking function and includes an end effector, an elongated portion and a handle portion. Two ends of the elongated portion are respectively connected to the end effector and the handle portion. The handle portion includes a handle housing, a rotatable knob arranged on a distal portion of the handle portion and operatively to be reciprocated along the longitudinal direction of the elongated portion, and a locking assembly including at least one slide member and a lockout gear. The slide member is arranged between the rotatable knob and the handle housing, and axially fixed with the rotatable knob so as to be reciprocated with the rotatable head for being operatively engaged with the slide member. The slide member is circumferentially fixed with the handle portion, and the lockout gear is rigidly mounted at a proximal portion of the elongated portion. The safety of the surgical instrument may be improved due to high structural stability and high stability between components.

Abstract: A loading unit of a powered surgical stapling instrument includes anvil and cartridge assemblies. The anvil assembly includes a first tissue contacting surface, and the cartridge assembly includes a second tissue contacting surface, a first plurality of staples, a second plurality of staples, and a plurality of pushers. The second tissue contacting surface defines a knife channel partitioning the second tissue contacting surface into first and second portions. Each of the first and second portions includes an inner tissue contacting surface and an outer tissue contacting surface. The inner tissue contacting surface defines a first row of retention slots. The inner tissue contacting surface and the first tissue contacting surface define a first tissue gap. The outer tissue contacting surface defines a second row of retention slots. The outer tissue contacting surface and the first tissue contacting surface define a second tissue gap larger than the first tissue gap.

Abstract: A surgical stapler, cartridge assembly, and related methods are disclosed. A cartridge assembly for a surgical stapler has a first cartridge portion; and a second cartridge portion; wherein each of the first and second cartridge portions has an upper surface for engaging tissue, and a slot to house a staple. A proximal portion of each of the first and second cartridge portions has a guide portion having at least one of a channel or a protrusion for guiding at least a portion of an i-beam. The second cartridge portion is removably couplable to the first cartridge portion to form a channel.

Abstract: A powered handle for a surgical stapler can have a drive system including an electric motor. The powered handle can include a manual articulation mechanism to articulate a jaw assembly coupled to a reload shaft connected to the handle. The manual articulation mechanism can include a ball screw mechanism that translates an articulation member responsive to rotation of an articulation knob when an instrument shaft is engaged with the handle. The articulation mechanism includes a release function that allows the jaw assembly to return to a longitudinally centered orientation. The powered handle includes a battery pack serving as a power supply for the drive system. A control system can control actuation of the motor based on user inputs and operating parameters of the stapler and can provide certain motor drive profiles for predetermined positions of the stapler. The powered handle can include a manual return mechanism.

Abstract: A surgical instrument and method for forming a plurality of staples in tissue of a patient includes a body having a firing mechanism, a shaft assembly, an end effector with an anvil, and a cartridge received within the end effector that is operatively connected to the firing mechanism. The cartridge includes a cartridge housing having a plurality of staple slots, a plurality of staples respectively positioned within the plurality of staple slots, and a driver assembly. The driver assembly has a plurality of drivers respectively supporting the plurality of staples within the plurality of staple slots. The firing mechanism is configured to selectively move the plurality of drivers distally toward the anvil for forming the plurality of staples therebetween. At least one driver of the plurality of drivers has a variable distal height relative to at least another driver of the plurality of drivers in a predetermined variable height pattern.

Abstract: A medical instrument having a tool assembly including a pair of opposing tissue engaging surfaces for clamping tissue therebetween. The medical instrument includes a housing having a fixed handle and a movable handle mounted to the housing and selectively movable relative to the fixed handle from a first position in spaced relation relative to the fixed handle to a second position closer to the fixed handle to actuate the clamping of tissue. The medical instrument includes a selectively activatable drive assembly including a power source and a motor which is operatively coupled to the movable handle, wherein upon actuation the motor actuates the pair of opposing tissue engaging surfaces. The drive assembly includes a controller configured to variably control the rate at which the motor actuates the pair of opposing tissue engaging surfaces in response to the force exerted on the movable handle.

Abstract: A surgical apparatus has a clamp and a stapling mechanism. The clamp has a first jaw and a second jaw to clamp on a body tissue at a desired location for a stapling operation. The stapling mechanism is controlled by a trigger handle or a switch assembly. The surgical apparatus has a controller for providing a delay between clamping and actuating of the firing mechanism of the stapling mechanism. The delay provides for a desired amount of time for tissue compression producing a more uniform staple formation. The surgical apparatus also has an indicator. The indicator provides feedback about the status of the stapling mechanism and also displays a time of tissue compression by the clamp.

Abstract: Systems include an end effector having a first jaw and a second jaw, a motor system configured to actuate the end effector, and a processor. The processor is configured to determine a maximum tip deflection for the end effector, determine a torque limit based on the maximum tip deflection, and operate, subject to the torque limit, the end effector using the motor system. In some embodiments, the maximum tip deflection is determined based a type of staple cartridge being used by the end effector. In some embodiments, the type of staple cartridge identifies a length of staples fired by the end effector. In some embodiments, the firing of the staples is stalled when an applied torque exceeds the torque limit. In some embodiments, the processor is further configured to fire staples subject to the torque limit.

Abstract: Medical devices disclosed herein include pre-defined structures for dispensing forces onto a tissue plane in a living organism and are utilized to adjust spatial relationships, orientations, and mechanical forces in a patient treatment area. The treatment area may be a wound, an incision, or a surgically accessed area within a patient that includes oppositely disposed sections that heal more efficiently and with less scarring when force vectors of a particular magnitude and direction are applied to the treatment area. The medical device provides a structure that may be pre-stressed through planned deformation that develops desirable spatial and mechanical relationships along the tissue plane for alignment, compression, advancement, eversion, inversion, distraction, rotation, angulation, and the control or modulation of tension across the treatment area.

Abstract: A surgical stapling instrument including a staple sled which can be advanced and/or retracted relative to first and second jaw members, wherein the staple sled can be configured to deploy staples from a staple cartridge in one of the first and second jaw members. In at least one embodiment, the other of the first and second jaw members can include an anvil having at least one forming surface which can be configured to deform the staples as they are deployed from the staple cartridge. In at least one form of the invention, the anvil can be movably adjustable relative to the staple cartridge in order to adjust the distance in which the staples are deformed. In various embodiments, the anvil can be adjusted by a slidable adjusting plate and/or a rotatable cam.

Abstract: A modular shaft assembly is disclosed. The modular shaft assembly includes one or more inputs configured to receive input motions from a surgical instrument system, such as a handle, for example. The shaft assembly further includes one or more on-board inputs configured to generate input motions. The input motions received and generated by the shaft assembly are transferrable to an end effector of the shaft assembly to perform various functions at the end effector. The end effector can include a staple cartridge and a firing member which is movable between a proximal position and a distal position to eject staples from the staple cartridge. The end effector can include a plurality of jaw members and the firing member can comprise camming members which are configured to position the jaw members relative to one another.

Abstract: A surgical staple cartridge is disclosed comprising a plurality of staples removably stored within the surgical staple cartridge. The staples comprise staple legs which extend from a staple base portion. The staple legs comprise staple tips configured to pierce tissue and contact a corresponding forming pocket of an anvil of surgical stapling instrument. The staples further comprise zones having different hardnesses.

Abstract: A surgical stapling device includes a handle assembly, a body portion extending distally from the handle assembly, a head portion including an anvil retainer and a shell assembly. The anvil retainer is movable in relation to the shell assembly between unapproximated and approximated positions. A tube surrounds a portion of the anvil retainer, wherein the anvil retainer includes a distal annular protrusion for releasably engaging an anvil assembly and wherein the anvil assembly includes a center rod.

Abstract: A surgical apparatus including a tool assembly is provided. The tool assembly includes a chip assembly, a staple cartridge body, a support plate, and a jaw member. The chip assembly includes a first projection facilitating alignment and connection with a connector assembly of the jaw. The chip assembly further includes a second projection received in a recess in the staple cartridge body. The connector assembly and chip assembly include an electrical connection therebetween.

Abstract: System for fixation of leaflets of a heart valve including a delivery catheter having an elongated shaft, a proximal end portion and a distal end portion configured to be positioned proximate native leaflets of a heart valve from a remote vascular access point, the delivery catheter further includes a rotatable actuator rod having a threaded fastener at a distal end thereof, and a fixation device releasably coupled by a threaded connection to the threaded fastener of the actuator rod. The fixation device includes a first arm moveable between a closed position and an open position, and a second arm moveable between a closed position and an open position.

Abstract: System for fixation of leaflets of a heart valve including a delivery catheter having an elongated shaft, a proximal end portion and a distal end portion configured to be positioned proximate native leaflets of a heart valve from a remote vascular access point, the delivery catheter further includes a rotatable actuator rod having a threaded fastener at a distal end thereof, and a fixation device releasably coupled by a threaded connection to the threaded fastener of the actuator rod. The fixation device includes a first arm moveable between a closed position and an open position, a second arm moveable between a closed position and an open position.

Abstract: System for fixation of leaflets of a heart valve including a delivery catheter having an elongated shaft, a proximal end portion and a distal end portion configured to be positioned proximate native leaflets of a heart valve from a remote vascular access point, and a fixation device releasably coupled to the delivery catheter. The fixation device includes a first arm moveable between a closed position and an open position, and a second arm moveable between a closed position and an open position. The fixation device further includes a first gripping element movable relative to the first arm in the open position, the first gripping element biased toward the first arm to capture a first leaflet of the heart valve therebetween, and a second gripping element movable relative to the second arm in the open position, the second gripping element biased toward the second arm to capture a second leaflet of the heart valve therebetween.