Abstract: An electrophysiologic catheter with a distal electrode assembly carrying very closely-spaced bipole microelectrodes on a plurality of divergent spines that can flexibly spread over tissue surface area minimized detection of undesirable noise, including far-field signals. Each spine has a flexible microelectrode panel having a substrate, at least one pair of microelectrodes, a trace for each microelectrode, and a soldering pad. Adjacent microelectrodes of a bipole pair are separated by a space gap distance ranging between about 50-300 microns. Each microelectrode may have a width of about 200 or 300 microns.

Abstract: A portable wireless neuromonitoring device can be used to diagnose and/or treat conditions of the brain and vision system. The device includes a sensor unit mountable on the head of a human subject and capable of recording signals from the brain in EEG and/or EFEG (electric field encephalography) mode, and the device can be used for simultaneous stimulus display and recording with latency of less than 1 millisecond. The device also includes electrodes that allow rapid set-up and measurement with low impedance contact with the scalp. The device can also be used in conjunction with virtual reality or alternate reality environments.

Abstract: According to various embodiments, a display device may be provided. The display device may include: a receiver configured to receive user data based on an electroencephalography measurement; at least one light source; and a controller configured to control the at least one light source based on the user data.

Abstract: Provided in the embodiments of the present disclosure are a control method and device based on brain signal, and a human-machine interaction device, which periodically acquire EEG signals and cerebral oxygen signals within a target period, generate an electroencephalogram (EEG) wave curve representing changes of the EEG signals and a cerebral oxygen wave curve representing changes of the cerebral oxygen signals respectively within the target period, determine whether the EEG wave curve and the cerebral oxygen wave curve satisfy a condition for controlling a controlled device to perform a target operation, and control the controlled device to perform the target operation when the EEG wave curve and the cerebral oxygen wave curve satisfy the condition.

Abstract: Methods for mental treatments, such as treatments for mental disorders, are described. Such methods can include measuring user brainwaves while the user plays a video game, such as a video game where the user is exposed to a competitive environment. The user can be rewarded within the video game based upon brainwave measurements.

Abstract: A system and methods for performing neurophysiologic assessments during surgery, such as assessing the health of the spinal cord via at least one of MEP and SSEP monitoring and assessing bone integrity, nerve proximity, neuromuscular pathway, and nerve pathology during spine surgery.

Abstract: The present specification describes systems and methods that enable the automatic detection, analysis and calculation of various processes and parameters associated with electromyography. The methods of the present specification include the automated modulation of analytical or recording states based on the nature of the signal, optimal reference fiber selection, modulating a trigger level, and determining firing parameters.

Abstract: According to various aspects, a new concept of Steady-State Visually Evoked Potential (SSVEP) based Brain-Computer Interface (BCI) is described where brain-computer communication occurs by capturing SSVEP induced by consciously imperceptible visual stimuli integrated into, for example, a virtual scene. These consciously imperceptible visual stimuli are able to convey subliminal information to a computer. In various embodiments, computer based operations can be mapped to visual elements with associated flickering stimuli, and induced SSVEP can be detected when the user focused upon them. In various embodiments, these visual elements can be introduced into existing display without any perceivable change to content being displayed.

Abstract: Electrical impedance monitoring of a tissue or an organ for perfusion or viability has been limited by sensitivity and baseline shifts. An apparatus and method are described which improve sensitivity by making the intervening tissue between pairs of electrodes a determinant component of electrical resonance. Such sensitivity further enhances detection of the pulsatile component of blood flow within a tissue. Baseline shift can be monitored and compensated due to resonance shift. The method is adaptable to sufficiency of perfusion monitoring or viability, imaging by 2-dimensional or 3-dimensional electrical impedance tomography, monitoring of tissue ablation by thermal or chemical methods, and thermoplasty of tissues to alter their form and functionality.

Abstract: The invention provides a sensor for measuring both impedance and ECG waveforms that is configured to be worn around a patient's neck. The sensor features 1) an ECG system that includes an analog ECG circuit, in electrical contact with at least two ECG electrodes, that generates an analog ECG waveform; and 2) an impedance system that includes an analog impedance circuit, in electrical contact with at least two (and typically four) impedance electrodes, that generates an analog impedance waveform. Also included in the neck-worn system are a digital processing system featuring a microprocessor, and an analog-to-digital converter. During a measurement, the digital processing system receives and processes the analog ECG and impedance waveforms to measure physiological information from the patient. Finally, a cable that drapes around the patient's neck connects the ECG system, impedance system, and digital processing system.

Abstract: A tactile sensing system includes at least a stretchable strain sensing layer, an inflatable reservoir, and a means for detecting strain in the stretchable strain sensing layer. The tactile sensing layer may be configured as a tumor detection system by configuring the inflatable reservoir to apply pressure to at least part of a tissue in conjunction with an anatomical contact structure and the stretchable strain sensing layer to be in contact with a region of the surface of the tissue.

Abstract: The present disclosure provides apparatuses and computer readable media for measuring sub-epidermal moisture in patients to determine damaged tissue for clinical intervention. The present disclosure also provides methods for determining damaged tissue.

Abstract: Systems and methods for evaluating neuromodulation via hemodynamic responses are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a neuromodulation catheter comprising an elongated shaft having a distal portion, and a plurality of electrodes spaced along a distal portion. The system can further include a controller communicatively coupled to the electrodes. The controller can be configured to apply first and second stimuli at and/or proximate to a target site within a blood vessel before and after delivering neuromodulation energy to the target site, and detect, via at least one of the electrodes, vessel impedance resulting from the first and second stimuli to determine a baseline impedance and a post-neuromodulation impedance. The controller can further be configured to assess the efficacy of the neuromodulation based, at least in part, on a comparison of the baseline impedance and the post-neuromodulation impedance.

Abstract: Navigation and simulation systems and methods for minimally invasive therapy in which the navigation system imports a planning method using patient specific pre-operative images. The navigation system uses intraoperative imaging during the medical procedure to update the preoperative images and provides images of tracked surgical tools along the surgical path prepared from the preoperative images.

Abstract: System and method for ingestion event detection and monitoring are disclosed. The system comprises: an ingestible microsensor configured to generate a signal representing an ingestion event upon ingestion and contact with stomach fluid of a patient; and a reader device positioned external to the patient and configured to detect the signal representing the ingestion event with at least 95% accuracy.

Abstract: The present invention relates to simple and integrated devices for assessing lung health. In one embodiment, an all-in-one device that is able to measure lung function, ventilation, inflammation and breath identification of aerosol propellant for monitoring asthma inhaler effectiveness and compliance. In another embodiment, the device uses a gas sensor composed of a sintered metal oxide and/or solid electrolyte that detects HFA-134a through a change in electrical conductivity or a change in voltage when gases are adsorbed on the sensor's surface.

Abstract: The present invention relates to the field of medical monitoring, and in particular non-contact, video-based monitoring of pulse rate, respiration rate, motion, and oxygen saturation. Systems and methods are described for capturing images of a patient, producing intensity signals from the images, filtering those signals to focus on a physiologic component, and measuring a vital sign from the filtered signals.

Abstract: In a method for alpha angle measurements of a bone joint based on magnetic resonance imaging (MRI) data of the bone joint, a three-dimensional (3D) bone surface image of the bone joint is generated based on two-dimensional (2D) segmentations on radial plane slices of the bone joint. Based on the 3D bone surface image, a head center of a head of the bone joint and a neck axis of a neck of the bone joint are estimated. An alpha angle model is constructed based on the estimated head center and neck axis. Further, the alpha angle measurement is determined for each of the radial plane slices of the bone joint based on the constructed alpha angle model.

Abstract: A respiratory monitoring device comprises: a light source (30) arranged to generate a projected shadow (S) of an imaging subject (P) positioned for imaging by an imaging device (8); a video camera (40) arranged to acquire video of the projected shadow; and an electronic processor (42) programmed to extract a position of an edge of the projected shadow as a function of time from the acquired video. In some embodiments, the light source is arranged to project the shadow onto a bore wall (20) of the imaging device, and the video camera is arranged to acquire video of the projected shadow on the bore wall. The electronic processor may be programmed to extract the position of the edge (E) as a one-dimensional function of time (46) based on the position of the edge in each frame of the acquired video and time stamps of the video frames.

Abstract: In one aspect, thermoelectric generators are described herein. A thermoelectric generator, in some embodiments, comprises a multilayer ribbon including an electrically insulating flexible substrate comprising a first side having a p-type material deposited thereon and a second side having an n-type material deposited thereon, wherein the p-type material and the n-type material are electrical communication. In another aspect, electronic systems for incorporation into apparel articles are described herein, which employ one or more energy harvesting mechanisms for powering various electronic functionalities. In some embodiments, for example, systems for monitoring apparel wear and/or use are provided. A system for monitoring apparel wear or use can comprise an energy harvesting component and a signaling component partially or fully powered by electrical energy generated by the energy harvesting component from wear or use of the apparel.

Abstract: Systems, devices, and methods are disclosed for the purpose of quantitatively determining the susceptibility of a human subject to injure their Anterior Cruciate Ligament (ACL). A method for determining injury susceptibility scores or risk categories includes determining hip extension angles and knee varus angles during the performance of a stork test and determining hip abduction angles during a squat test. Determination of angles during certain movements may be achieved using various systems and devices, including wearable devices.

Abstract: A controller corrects a spectrum S (?) detected at a wavelength ? of signal light to S? (?) in accordance with expressions below: I(?)=(I2?I1)×(???1)/(?2??1)?I1, and S?(?)=S(?)?I(?), where I1 is the intensity of infrared light detected at a wavelength ?1 of reference light and I2 is the intensity of infrared light detected at a wavelength ?2 of correction light.

Abstract: Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice.

Abstract: A wearable patch for measuring the biochemical composition of a fluid is disclosed. The wearable patch of the present disclosure may comprise a bonding layer configured to adhere to a subject's skin; a microfluidic chip comprising at least one inlet, a plurality of channels and at least one outlet; an electronic chip assembly comprising at least one sensor, the at least one sensor configured to align with the at least one outlet of the microfluidic chip; a wicking layer configured to move the sweat collected in the at least one outlet through the at least one sensor; and a protective layer.

Abstract: A flexible, multi-layered device for automatically sensing sweat biomarkers, storing and transmitting sensed data via wireless network to a computing device having software applications operable thereon for receiving and analyzing the sensed data. The device is functional in extreme conditions, including extremely hot temperatures, extremely cold temperatures, high salinity, high altitude, extreme pHs, and/or extreme pressures.

Abstract: A device (100) for sensing sweat on skin (12) includes a first analyte-specific sensor (120, 122) for sensing a first analyte in sweat; a sweat stimulating component (140); a waste collector (142, 144, 146, 148) beneath the sweat stimulating component (140); and an additional component being one or more of a sweat collector (130, 132, 134) or an additional analyte-specific sensor (124) for sensing an additional analyte in sweat that is different from the first analyte, the additional component being adjacent to and fluidically isolated from the waste collector (142, 144, 146, 148). A device (200) for sensing sweat on skin (12) includes a first portion comprising a first analyte-specific sensor (220) for sensing a first analyte in stimulated sweat and a sweat stimulating component (240); and a second portion comprising a second analyte-specific sensor (225, 226) for sensing a second analyte in natural sweat.

Abstract: Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with an enhanced carbon-enzyme layer that in one embodiment is made by mixing an aqueous polyurethane emulsion with an acrylic polyol emulsion to make a base emulsion. An enzyme and carbon materials are added to the base emulsion, which is applied to the working electrode and cured. The carbon materials may include carbon and graphite to provide strength, as well as graphene or pyrolytic graphite to provide a desirable electrical resistance for the carbon-enzyme layer. Optionally, other additives can be added to the base emulsion prior to application, such as hydophiles, cross linkers, adding imodeoesters, hydroxysuccimide, carboldilite, melamines, epoxies, benzoyl peroxide or dicumyl peroxide.

Abstract: Systems and methods for analyte monitoring, particularly systems and methods for monitoring and managing life of a battery in an analyte sensor system worn by a user, are provided.

Abstract: The present disclosure describes the derivation and measurement of a fractional oxygen saturation measurement. In one embodiment, a system includes an optical sensor and a processor. The optical sensor can emit light of multiple wavelengths directed at a measurement site of tissue of a patient, detect the light after attenuation by the tissue, and produce a signal representative of the detected light after attenuation. The processor can receive the signal representative of the detected light after attenuation and determine, using the signal, a fractional oxygen saturation measurement based on two or more different measures of fractional oxygen saturation.

Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.

Abstract: Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with a new interfere layer that is (1) non-electron conducting, (2) ion passing, and (3) permselective for molecular weight. The new interference layer is made by mixing a monomer and a mildly basic buffer, and then electropolymerizing the monomer and the buffer into a polymer. The polymer is deposited onto a working electrode for a continuous metabolic monitor, for example, using an electro depositing process in the form of cyclic voltammety (CV). The interference layer is permselectable for molecule size by adjusting the pH of the basic buffer.

Abstract: The sensor includes a working electrode having a first wire with a first flat surface and an electrochemical element on the first flat surface. A reference electrode includes a second wire with a second flat surface and a counter electrode includes a third wire with a third flat surface. The first wire is a first sensor wire for the working electrode, the second wire is a second sensor wire for the reference electrode and the third wire is a third sensor wire for the counter electrode in a plurality of sensor wires. The second flat surface and the third flat surface face toward each other.

Abstract: An apparatus includes a body and an actuator is coupled to the body. A needle is mounted to the actuator. The needle comprises a slot along a length to a tip. A sensor is coupled to a plurality of wires. A base is configured to be moveable by the actuator and includes a cutout, a circuit board having a microprocessor, and a plurality of contacts. Each contact is coupled to a wire of the plurality of wires. A power source is connected to the circuit board and to the base. A bracket is coupled to the bottom surface of the body and configured to receive the base. A patch is coupled to the bracket and has an adhesive. A needle is configured to be moveable by the actuator. The plurality of wires extend from the circuit board of the base, through the needle and out of the slot.

Abstract: A secure specimen sample bottle includes a base container for receiving a specimen. The base container has a plurality of locking protrusions formed along an inner surface of the base receptacle. A bottle includes a lock ring that has an upright spire structure that has a closed top end and the opposing open bottom end including a plurality of flexible fins that are configured to interlockingly mate with the locking protrusions so as to prevent removal of the lock ring relative to the base container upon engagement of the flexible fins to the locking protrusions. A removable cap is coupled to the lock ring.

Abstract: A system, mixing-enhanced microfluidic container, and methods for small volume sample collection and/or analysis is disclosed. Namely, the invention is directed to a small volume sample collection system that includes a mixing-enhanced microfluidic container and a durable reusable actuation chuck. The mixing-enhanced microfluidic container is used to collect small volumes of sample fluid and includes a means for mixing the sample fluid with reagents disposed within the microfluidic container. The mixing means utilize an array of surface-attached structures (e.g., a micropost array). The application of an “actuation force,” such as a magnetic or electric field, actuates the surface-attached structures into movement, wherein the actuation chuck in close proximity to the mixing-enhanced microfluidic container provides the “actuation force.

Abstract: Embodiments are directed to identifying and measuring bodily states and feedback systems. A computer system initializes a tracking and measuring device to generate patient data related to a bodily state or feedback system of a patient. The computer system gathers the patient data using the initialized tracking and measuring device, and identifies a baseline parameter used to determine a baseline state relative to the gathered patient data. The computer system further gathers additional patient data using the initialized tracking and measuring device and compares the additional gathered patient data to the identified baseline parameter. Then, if the additional gathered patient data differs from the baseline state by a specified threshold amount, the computer system determines that a change in the patient's bodily state or feedback system has occurred and/or determines the amount of change in the bodily state or feedback systems that has occurred.

Abstract: Methods and systems for classifying a subject's cognitive state are provided. The method receives and stores sensor signals comprising a first sensor signal (SS_1) from a first sensor configured to sense a first aspect of the subject, and a second sensor signal (SS_2) from a second sensor configured to sense a second aspect of the subject. The validity of SS_1 and SS_2 are determined using a binary signal validity methodology and a weighted signal validity methodology. SS_1 and SS_2 are analyzed to identify patterns therein, and the patterns are defined as either an objective marker or a subjective marker. A subject profile is referenced and updated through multiple iterations. The subject's cognitive state is subsequently classified based on both adjusted subjective and objective markers.

Abstract: Provided is a process including: receiving biometric measurements; receiving from application components or network hosts, events or metrics indicative of objective performance; correlating psychophysical-performance values based on the biometric measurements indicative of psychophysical performance with objective-performance values based on the events or metrics indicative of objective performance; storing the correlation between the psychophysical-performance values and the objective-performance values in memory; and accessing the correlation to select hosts, application components, or routines to be adjusted to improve objective performance of the distributed application or psychophysical performance of the distributed application.

Abstract: An apparatus for determining balance compensation includes a platform, sensors and a processor. The platform is configured for a person to stand on the platform. The sensors are coupled to the platform and measure at least one of a weight and a pressure. The processor determines a balance of the person based on the measurements of the sensors.

Abstract: The present specification describes a system for diagnosing or screening one or more pathologies in a patient. The system includes a headset with at least one microphone or accelerometer to passively receive vibrations generated by the cerebral vasculature of the patient's brain, computing devices coupled with the headset for processing the received vibrations to obtain a unique signal, and a signal analyzer to analyze the signal in order to determine if the data includes patterns uniquely indicative of at least one of tension headaches, migraines, depression, dementia, Alzheimer's disease, epilepsy, Parkinson's disease, autism, cerebral vasospasm and meningitis.

Abstract: An apparatus including a wearable holder and a test material unit and a method for assessing skin reactivity to a test material are disclosed. The wearable holder is configured to hold the test material against the wearer's skin over a period of time to allow for an assessment of skin reactivity to the test material. The apparatus is provided to meet the needs of different patient populations.

Abstract: Systems and methods for measuring autofluorescent signals from lipopigments associated with various disease states are disclosed.

Abstract: Methods, compositions and systems are provided for the imaging of cavity/tissue lesions, including without limitation cavity/tissue malignant lesions, e.g. cancers of the skin, mouth, colon, digestive system cervix, bladder, lung, etc.

Abstract: A method for determining a user-specific hair treatment by determining and inclusion of the degree of damage of hair is provided. To this end, initially, with the aid of near-infrared and/or infrared spectra of the keratin fibres of an individual, the amino acid oxidation product content is determined and a degree of damage is derived from it via a calibration model. Individual treatment advice that is based on the determined degree of damage is issued.

Abstract: An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).

Abstract: A biofeedback system for monitoring patient-related signals of a patient having adolescent idiopathic scoliosis (AIS) is disclosed. The present invention provides a personalized biofeedback to the patient based on the patient-related signals for restoring balance in muscle activities and reducing displacement of both sides of the patient's spine as a treatment for AIS. The biofeedback system comprises clothing integrated with posture monitoring sensors, and one or more computational systems comprising a sensor-based sEMG posture training subsystem for providing posture training and a posture monitoring subsystem for providing progressive training through daily activities. The sensor-based sEMG posture training subsystem comprises a posture training device coupled to a plurality of sEMG sensors, a feedback device and a calibration system.

Abstract: Disclosed are a thermotherapeutic apparatus having a function of measuring a heart rate and a method of controlling the same. The thermotherapeutic apparatus includes a pretreatment portion which extracts a ballistocardiogram signal sensed by a weight detecting sensor, a heartbeat signal extractor which extracts a heartbeat signal from the pretreated signal, and a mode performer which performs control to calculate a heart rate on the basis of the extracted heartbeat signal, to determine a massage mode according to the calculated heart rate, and to automatically set a massage pattern, a massage level, and a massage temperature of the corresponding massage mode so as to perform the corresponding massage mode.

Abstract: A system for collecting cannabis and the psychoactive component tetrahydrocannabinol or other controlled substances from a sample of exhaled breath. Single or multiple exhaled breaths are conditioned by removing contaminants, and regulating flow rate and/or pressure to collect a sample of tetrahydrocannabinol for timely local or remote analysis using FAIMS. The cannabis detection system comprises a containment trap for removing interfering materials from the breath of the subject and a collection component for sampling components of breath introduced into the system through the containment trap for FAIMS analysis to determine the level of THC or other controlled substance in the breath.

Abstract: The invention relates to a method for measuring and displaying data linked to a person's physical activity, comprising: measuring data linked to the person's physical activity using a mechanical sensor in a wrist watch worn by the person; displaying the measured data on the watch face; taking an image of the watch face using a camera in an electronic device; analysing the image in order to determine the data; processing the data so as to process the analysed data; and displaying the processed data on a screen of the electronic device.

Abstract: Devices, methods, computer-readable media, and systems for determining an identity of a food are disclosed. For example, a method may receive at least one property of at least one component in a sample of a food from an intra-oral device including a spectrometer, the at least one property obtained via the spectrometer, compares the at least one property to a plurality of food signatures, and determines the identity of the food based upon the comparing. In another example, a system may include an intra-oral device and a wireless device. The intra-oral device may include a spectrometer for measuring at least one property of at least one component in a sample of a food. The wireless device may include a processor for receiving the at least one property, comparing the at least one property to a plurality of food signatures, and determining the identity of the food based upon the comparing.