Abstract: Actuators and methods of use are provided. An actuator may include an inner member made from an elastic material and defining a compartment for receiving an actuating fluid, the inner member being moveable in a longitudinal direction from a relaxed state to an expanded state by introducing an actuating fluid into the inner member; and an outer member made from an inelastic material and being disposed around the elastic inner member to control expansion of the elastic inner member in a radial direction, the outer member being moveable from a folded relaxed configuration to an unfolded extended configuration as the inner member moves from the relaxed state to the expanded state, wherein the movement of the actuator between the relaxed state and the expanded state causes a movement of a structure to which the actuator is attached.

Abstract: The present invention relates to a system and a method for controlling a joint angle of a knee-joint type walking training robot which estimates a walking stage of a person receiving rehabilitation for walking and actively responds to the walking stage on the basis thereof. The present invention can easily control the joint angle of the knee-joint type walking training robot by providing a configuration comprising: a pressure measuring device for measuring the pressure on the sole of a walker's foot by using a pressure sensor; and a joint angle estimating device for estimating the joint angle of a knee-joint by extracting movement time of the walk and the length of the part of the sole contacting the ground on the basis of the sole's pressure measured by the pressure measuring device.

Abstract: Gait rehabilitation systems, methods, and apparatuses thereof are disclosed. In accordance with one aspect of the invention, a gait rehabilitation system may include a harness configured for attachment to an individual and at least one sensor configured to sense at least one parameter associated with gait of an individual, the individual having an affected leg and an unaffected leg. The system includes a braking system configured for attachment to the harness and in communication with the at least one sensor. The braking system is further configured for monitoring the at least one sensor to sense the at least one parameter associated with an individual's gait, determining when the affected leg is in a modification portion of the individual's gait from the sensed at least one parameter, and applying a braking force resisting movement of the harness during the determined modification portion.

Abstract: A rigid tool is used in fascia therapy and includes a handle and a blade. The handle is an elongate cylinder having a length of 4.5 inches and a diameter of 1 inch. The blade is a flat plate having a thickness ¼ inch and a width of 4.5 inches. The blade is rigidly affixed at a proximal end to and extends outwardly from the handle. The blade has a distal edge with a curved contour devoid of sharp corners across its width.

Abstract: A device for providing thermal treatment to a patient's hand is provided. The device includes a therapy component for applying thermal therapy, compression therapy, or both; a sleeve for receiving the therapy device and sized and shaped to cover the patient's hand; and a hand support for supporting the patient's hand in a relaxed state.

Abstract: The present invention relates to devices for dermatology and more particularly to fluid enhanced skin treatment system for skin rejuvenation that can optionally use an abrasive probe for removing epidermal layers while contemporaneously providing for the infusion of therapeutic fluids into the skin.

Abstract: A massage shower head includes a main body, a water outlet cover, and a plurality of massage balls. The main body is provided with a water inlet. A front of the main body is defined as a water outlet side. The water outlet cover covers the water outlet side of the main body. The massage balls are movably disposed between the main body and the water outlet cover. The water outlet cover has a plurality of openings. The massage balls partially extend out from the openings, respectively. The massage balls are arranged on the water outlet side of the shower head to realize the massage function while taking a shower and achieve the effect of scrubbing the user's skin.

Abstract: A device for use by an individual for sexual pleasure varying in form, i.e. shape, during its use and allowing for the user to select multiple variations of form either discretely or in combination and for these dynamic variations to be controllable simultaneously and interchangeably while being transparent to the normal use of the device, including the ability to insert, withdraw, rotate, and actuate the variable features manually or remotely. According to embodiments of the invention localized and global variations of devices are implemented using fluidics and electromagnetic pumps/valves wherein a fluid is employed such that controlling the pressure of the fluid results in the movement of an element within the device or the expansion/contraction of an element within the device.

Abstract: A sex toy includes a handle member forming a handle portion which can be manually grasped and held and/or can be strapped in place with an elongate connector portion at one end or both ends of the body together with a set of separate penetrative head portions each having an outer surface which is flexible and each having a receptacle therein for engaging onto the connector portion and a generally cylindrical penetrative portion arranged to extend forwardly from the handle member. The set of the head portions have different outside shapes and/or dimensions arranged such that each can be engaged separately onto the handle member when selected.

Abstract: A micro facial massager includes a housing, a circuit board, a driving motor, an eccentric wheel arranged on an output shaft of the driving motor, a massage piece, batteries received by a battery box which is positioned in a placed groove. A through hole is defined in a bottom of the placed groove. The battery box is dismountable and is insertable into the housing. The micro facial massager further includes two metal connectors, where the two metal connectors are corresponding fixed in the housing and are connected with the circuit board. When the battery box is inserted into the housing, the two metal connectors press an anode and a cathode of the battery, respectively. Thus, it is convenient to only open the battery box to replace the batteries.

Abstract: Systems and methods for monitoring medication adherence and compliance are provided. A medication monitoring system may include a medication container, a cover, and a beacon system. The beacon system may include a beacon that transmits a wireless signal when the cover is removed from the medication container. A method for monitoring medication adherence and compliance may include detecting when a cover of a medication container is removed from the medication container. The method may further include transmitting based on the detection, a signal from a beacon to a remote device, which indicates the opening of the medication container.

Abstract: A package has a plurality of seamless compartments coupled together. A different one of the plurality compartments each includes a different respective one of a plurality of respective void spaces and a different respective one of a plurality of respective void space delimiting surfaces. A different one of a plurality of fill entries each forms a fluent entry into a different respective compartment's void space. At least one fill entry of said plurality is in an elastomeric portion of said package, and the at least one fill entry has a largest cross sectional area which is equal to or less than 25% of a largest cross sectional area of the compartment having the respective void space for which the fill entry forms the fluent entry. Each void space delimiting surface follows an outline of a separate 3D pill shape.

Abstract: An ampoule for a medical liquid comprises an ampoule body for accommodating a medical liquid and a connection part for connecting a removal device to the ampoule, which connection part extends in a longitudinal extension direction and adjoins the ampoule body. The connection part and the ampoule body are formed as one piece and the connection part has a threaded segment having at least two thread turns arranged thereon, which are axially offset from each other in the longitudinal extension direction. The ampoule enables simple attachment of a removal device, creates a tight transition between a connection part and the removal device, is simple and economical to produce, and can provide a defined attachment state for the removal device on the ampoule.

Abstract: A syringe adapter includes a housing having a first end and a second end with the first end configured to be secured to a first container, a cannula having a first end and a second end with the second end positioned within the housing, and a collet having a first end and a second end with at least a portion of the collet received within the housing. The collet includes a body defining a passageway, a seal member received by the passageway, and an arcuate, resilient locking member connected to the body of the collet. The collet is movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted.

Abstract: The present invention relates to a capsule filling machine for filling a capsule (20), which comprises an upper capsule part (21) and a lower capsule part (22). Said capsule filling machine comprises a plurality of separate stations for handling the capsules (20) and a capsule separation device (30) and a capsule presence device (40), the capsule separation device (30) and the capsule presence device (40) being integrated into a common station (2).

Abstract: A feeding assembly to fill capsules with granules, in particular microgranules, has a filling drum, which is provided with a plurality of fillers, each defined by a respective suction pipe, which can be connected to a pneumatic sucking device and has a lower end to pick up/release the granules; the lower end of each suction pipe being closed by a closing element provided with a plurality of openings, each designed so as to prevent the granules from getting into the suction pipe.

Abstract: This invention provides a controlled dosage form-dispensing device, comprising a multi-chamber, bulk medicine storage and distribution unit, wherein said unit is provided with a plurality of individual dosage form-containing storage chambers with respective delivery ports; and a personal medication dispenser comprising a fixed dosage form extracting station comprising a dosage form receiving and extracting mechanism; wherein the medication dispenser is provided with a controller which moves the bulk medicine storage and distribution unit sequentially bringing a respective delivery port of a predetermined chamber into register with the fixed dosage form extracting station such that the dosage form receiving and extracting mechanism extracts and receives only one dosage form at a time.

Abstract: Provided herein is a self-etching dental adhesive that exhibits excellent adhesiveness not only to dentin untreated by phosphoric acid etching, but to dentin treated by phosphoric acid etching. The present invention relates to a dental adhesive containing a (meth)acrylamide compound (a), an asymmetric acrylamide-methacrylic acid ester compound (b), and an acid group-containing (meth)acrylic polymerizable monomer (c). The (meth)acrylamide compound (a) is at least one selected from the group consisting of compounds represented by general formula (1), and compounds represented by general formula (2). The asymmetric acrylamide-methacrylic acid ester compound (b) is a compound represented by general formula (3). (In the formulae, the meanings of the symbols are omitted.

Abstract: The subject of the present disclosure are intended to oxidative hair coloring, containing from about 60-about 83 weight-% water, oxidation dye precursor(e), alkalization resources and a specific mixture of a networked Copolymer of acrylic acid and non-ethoxy controlled Esters of acrylic acid with linear C10-C30 alkan mono alcohols, carboxylic acid, glyceryl fatty acid esters, surfactant, branched C10-C50-Alkanol and linear, saturated C8-C22 alkan-1-ol, whereby the coloring agent has an optimum viscosity for the application and the consistency of a gel-like cream with outstanding haptics.

Abstract: Disclosed are methods, compositions and kits for whitening teeth and promoting better oral hygiene. A one-step protocol is disclosed in which concentrated hydrogen peroxide is delivered into the oral cavity by aerosol spray, without burning, discomfort or damage to the soft tissues of the mouth. A two-step protocol is also disclosed in which an effervescent powder formulation is included as a post-treatment following the aerosol spray. In some embodiment, the powder formulation can be used alone to promote remineralization, reduce plaque, reduce bacterial count and generally enhance oral hygiene.

Abstract: The present invention generally relates to a water-in-oil emulsion comprising at least one oil-soluble polar modified polymer and at least one polylysine, wherein the emulsion has a high water content.

Abstract: The present invention provides an oil-in-oil type cosmetic composition that has excellent transfer resistance after application, a luster, favorable spreadability during application, and also excellent stability. The oil-in-oil type cosmetic composition comprises (a) 5 to 80% by mass of non-volatile hydrocarbon oil, (b) 1 to 70% by mass of non-volatile silicone oil, and (c) 0.1 to 10% by mass of dextrin fatty acid ester. Preferably, the non-volatile hydrocarbon oil (a) and the non-volatile silicone oil (b) are formulated at a ratio (mass ratio) of (a)/[(a)+(b)]=0.4 to 0.8.

Abstract: Perfume composition provided in the form of a plurality of dispersed perfume-containing droplets, suspended in an aqueous dispersing medium, said perfume droplets being mono-dispersed and having a diameter of 200 micrometers to 4000 micrometers, wherein said droplets comprise more than 60 wt %, of perfume ingredients, and wherein 25 wt or less of said perfume ingredients are linear or branched alkyl alcohols and/or alkenyl alcohols; 10 wt % or less of the perfume ingredients are aldehydes; and 10 wt % or less of the perfume ingredients have a ClogP less than 2.1.

Abstract: The aspects presented herein provide methods and compositions for the reduction of the peroxide value of perfume ingredients, formulated perfumes, formulated body care products, formulated skin care products, formulated homecare products, essential oils, food raw materials, formulated food products, and natural extracts.

Abstract: The present invention relates to a formed fabric which contains cellulose fibers, which contain zinc oxide particles which are at least partially incorporated and which is additionally impregnated with a liquid, and to a method of its production and to its use, in particular for manufacturing preservative-free, moist wet wipes.

Abstract: The invention concerns ready to use compositions for the reshaping and direct coloring of hair comprising glyoxylic acid, a glyoxyloyl amino acid or a mixture thereof and a direct dye, and a method for reshaping and coloring of hair by means of said compositions.

Abstract: The present invention is directed to combination sunscreen and insect repellant compositions. The combination sunscreen and insect repellant compositions contain (i) diethyl toluamide (or N,N-Diethyl-3-methylbenzamide or DEET), and (ii) one or more sunscreen components, with each sunscreen component being capable of absorbing ultraviolet light rays. The combination sunscreen and insect repellant compositions may contain additional composition components such as a polymeric binder system, and deionized water. The present invention is also directed to methods of making and using combination sunscreen and insect repellant compositions.

Abstract: The instant disclosure relates to microemulsion compositions comprising polydatin, which are useful as cosmetic and/or pharmaceutical compositions for application to the skin and/or hair. The microemulsion compositions comprise: (a) polydatin; (b) optionally, niacinamide; (c) optionally, baicalin; (d) one or more oils; (e) water; and (f) one or more emulsifiers. Furthermore, the ratio of the total amount of the one or more emulsifiers to the total amount of the one or more oils is typically 1.7 to 2.5.

Abstract: Disclosed is an oral or topical composition comprising a nuclear factor erythroid-2 related factor 2 agonist and a liver X receptor agonist, wherein the amounts of each of the nuclear factor erythroid-2 related factor 2 agonist and the liver X receptor agonist produce a synergistic benefit of hair fiber growth, wherein the oral or topical composition comprises ?9, preferably ?8% w/w ?-sitosterol, wherein when the oral or topical composition comprises a catechin, the oral or topical composition comprises 0.001 to 90, preferably 0.005 to 70, most preferably 0.

Abstract: The present invention intends to provide a composition for hair and skin treatment containing a combination consisting of silk amino acid and protein complexes, seed oils, polysaccharides, polyol, monosaccharide, and botanicals. The composition for hair and skin treatment containing the combination consisting of silk amino acid and protein complexes, seed oils, polysaccharides, and botanicals has excellent improvement effects on the condition of the hair follicle and cuticle, imparts moisture to dry hair; thereby reducing the damaging effects of psoriasis, eczema, alopecia, and seborrheic dermatitis. Furthermore, it imparts retention of moisture to the skin resulting in an improved appearance and diminished appearance of lines on the skin. This invention relates to the manufacture of personal care products to be applied to the hair and skin. The compositions may be in the form of hair conditioners, hair growth treatments, shampoos, skin care, skin cleansing, or anti-wrinkle products, and ointments.

Abstract: The invention relates to cosmetic formulations and new peptide related entities designed for the cosmetic treatment of the human skin. In more detail, the invention is related to peptides that target CD90 positive tissue cells and correspond to or derive from the partial sequence of erythropoietin (EPO) but do not substantially elicit a hematopoietic but a tissue regenerative and protective effect. In particular, the invention discloses EPO-derived tissue-protective peptides in functional relation to lipid structures and agents that trigger vasculature relaxation and promote transdermal transport of the polypeptide entities to the targeted skin cells.

Abstract: The present invention refers to the injectable hyaluronic acid composition which is crosslinked viscoelastic hyaluronic acid gel comprising DNA fractions. More particularly, it refers to the injectable hyaluronic acid composition comprising a hyaluronic acid composition crosslinked in the basic conditions with the degree of crosslinking between 0.1 and 200%, which is mixed with the DNA fractions of 0.1 to 50 wt %. The DNA fractions are selected, for example, from polynucleotide (PN) and polydeoxyribonucleotide (PDRN). The composition used for cosmetic purposes or therapeutic purposes, have improved viscoelastic rheological properties and enzyme resistance.

Abstract: A cosmetic composition for the temporary shaping of keratinic fibers, containing: a) at least one non-crosslinked, hydrophobically modified (meth)acrylic acid copolymer b) at least one, at least partially imidized maleic anhydride copolymer, its use and method using such a composition.

Abstract: The disclosure relates to a cosmetic product for temporary shaping keratin fibers, in particular human hair, containing a combination of a copolymer A based on vinylpyrrolidone with copolymer B based on acrylates. Said cosmetic product has a good level of moisture resistance. The disclosure also relates to the use of said cosmetic product and to a method for temporary shaping keratin fibers using said product.

Abstract: The present invention provides an eye make-up cosmetic composition containing a low-specific-gravity oil and a low-specific-gravity powder. The present invention provides an eye make-up cosmetic composition with excellent curling holding force, wherein the composition does not contain water and aqueous ingredients at all and contains a low-specific-gravity oil and a low-specific-gravity powder together, thereby allowing a formed curling force to be maintained as is, all day, when the composition is coated on hair such as the eyelashes.

Abstract: There is provided an organopolysiloxane which is excellent in extensibility as well as solubility and dispersibility in water and lower alcohols. There is provided an organopolysiloxane with a poly(N-acylalkyleneimine) segment having a repeating unit represented by the following general formula (1): wherein R1 represents a hydrogen atom or an alkyl group, an aralkyl group, or an aryl group each having 1 to 22 carbon atoms, and n is 2 or 3, wherein the segment is bound to each of at least two silicon atoms of an organopolysiloxane segment as a main chain via an alkylene group containing a hetero atom, and wherein the number-average molecular weight of the segment is 800 to 1600, the mass ratio of the organopolysiloxane segment as a main chain and the poly(N-acylalkyleneimine) segment is 65/35 to 82/18, and the weight-average molecular weight of the organopolysiloxane segment as a main chain is 10,000 to 100,000.

Abstract: The present disclosure relates to a cosmetic agent for dyeing keratinous fibers, more particularly human hair, containing at least one special hydroxy-terminated, amine-functionalized silicone polymer and at least one oxidative dye precursor and/or one partially-oxidative dye, the use of the at least one hydroxy-terminated, amine-functionalized silicone polymer leading to improved nourishment of the keratinous fibers with extremely low color shift at the same time. The present disclosure also relates to a corresponding kit-of-parts, as well as a method for dyeing keratinous fibers. Finally, the present disclosure relates to the use of the cosmetic agent as contemplated herein, as well as the kit-of-parts as contemplated herein.

Abstract: The invention relates to a personal care composition which provides enhanced inter-cellular tight junction in skin cells. The invention more particularly relates to use of such composition for application on skin, scalp, hair and oral cavity. The personal care composition comprises an extract of Aloe vera and a hyaluronic acid polymer having a molecular weight from 5 to 60 kDa.

Abstract: The present invention provides stable, ready-to-use injectable pharmaceutical compositions, comprising the combination of neostigmine, glycopyrrolate, a stabilizing amount of one or more aminopolycarboxylic acids, and a pharmaceutically acceptable liquid vehicle. Other aspects of the invention relate to methods for making such compositions and methods of using such compositions for reversing the effects of non-depolarizing neuromuscular blocking agents. Preferably, the composition comprises neostigmine methylsulfate, glycopyrronium bromide, ethylenediaminetetraacetic acid (EDTA) and a pharmaceutically acceptable liquid vehicle, and is provided in a pre-filled, ready-to-use sealed container, such as a pre-filled syringe, suitable for intravenous administration.

Abstract: A pharmaceutical hydrocortisone solution including at least hydrocortisone or a pharmaceutically-acceptable salt thereof, rongalite, disodium EDTA, and a solvent. Also relates to its use in the treatment of acute adrenal insufficiency and asthma. Also relates to an injection kit including an injection device and this pharmaceutical solution.

Abstract: Described herein are methods and devices for the long term treatment of ophthalmic disorders. Also disclosed are encapsulated cell therapy (ECT) devices that secrete a biologically active molecule and methods for using the same for the treatment of various kinds of ophthalmic disorders, including retinitis pigmentosa, geographic atrophy (dry age-related macular degeneration), glaucoma and/or macular telangiectasia.

Abstract: An orally administrable chewing gum formulation is provided comprising a pharmaceutically acceptable gum base and particles of a pharmaceutical agent ranging in size from about 50 to about 2000 ?m, wherein the formulation comprises about 0.5-30% by wt of the pharmaceutical agent particles. A liquid formulation comprising particles of a pharmaceutical agent is also provided.

Abstract: This invention is directed to a pharmaceutical composition for drinking water administration comprising isoxazoline compounds of formula (I) and a polysorbate surfactant and diethylene glycol monoethyl ether (transcutol); and the use of the composition to treat or prevent parasite infestations of animals.

Abstract: Disclosed is a synergistic beverage composition for alleviating alcohol-induced oxidative stress, hepatic stress, CNS stress, veisalgia and modulating immunology parameters. The composition includes saponin glycoside, amino acid derivative and sugar or sugar alcohol as active ingredients and pH adjusting agents and flavoring agents as inactive ingredients. The calculated proportions of amino acid derivatives, Saponin glycoside and sugar or sugar alcohol in the alcohol exhibit synergistic effects, thereby alleviating oxidative stress, hepatic stress, CNS stress, veisalgia and modulating immunology parameters, which could ultimately leads to prevention of alcohol-induced damage or impairment of organs, which could be temporary or permanent.

Abstract: Irinotecan phospholipid liposomes with improved storage stability are provided, with related methods of treatment and manufacture. The irinotecan liposomes can have reduced formation of lyso-phosphatidylcholine (lyso-PC) during storage, and prior to administration to a patient.

Abstract: In accordance with one aspect, embolic particles are provided which comprise sub-particles that comprise a therapeutic agent of low solubility dispersed in a matrix that comprises a biodegradable polymer. Other aspects pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions. Still other aspects pertain to methods of making such particles.

Abstract: Provided are a composition containing an unstable drug against oxidation like pemetrexed with improved stability and a preparation method thereof, by removing oxygen during the preparation. The method is readily applicable for manufacturing by freezing and degassing in a sealed chamber, and can provide formulations with significantly increased stability for the unstable drug against oxidation.

Abstract: The invention discloses a composition comprising surface modified iron oxide nanoparticles with citric acid modified cyclodextrin with a hydrodynamic diameter of less than 10 nm and a hydrophobic molecule. The composition finds use in targeted delivery of a hydrophobic drug and as contrast agent in imaging applications.

Abstract: Subject of the present invention are assays and in vitro methods for the in vitro diagnosis, prognosis and risk stratification of a patient having a primary, non-infectious disease, whereby the level of Procalcitonin (PCT) in a sample of a body fluid of the patient is indicative for the risk of the patient to contract a further disease or medical condition.

Abstract: Pharmaceutical formulations of ?-Caryophyllene, and methods of supporting and promoting bone health using ?-Caryophyllene, are described.