Patents Issued in October 29, 2019
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Patent number: 10456466Abstract: The present invention relates to antibodies which specifically bind vascular endothelial growth factor (VEGF), in particular heavy-chain antibodies, and more particularly single-domain antibodies. The present invention also relates to a method of producing the antibodies and the therapeutic uses thereof.Type: GrantFiled: January 6, 2015Date of Patent: October 29, 2019Assignee: Zhuhai Essex Bio-Pharmaceutical Co., Ltd.Inventors: Haizhou Fang, Wei Qu, Zanshun Zheng, Lanfang Zhuang, Xinzhi Wang
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Patent number: 10456467Abstract: A magnetic nanoparticle including a TRPV1 agonist, as well as methods of preparation and use, are described herein. A magnetically responsive pharmaceutical can include a core region having a magnetic nanoparticle (MNPs) and a TRPV1 protein agonist. Further, an exterior coating comprising a polymer can be formed around the core region. The magnetically responsive pharmaceutical can be administered to a recipient and directed to a target region using an external magnetic field.Type: GrantFiled: August 28, 2017Date of Patent: October 29, 2019Assignee: UNIVERSITY OF WYOMINGInventors: Baskaran Thyagarajan, Padmamalini Baskaran
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Patent number: 10456468Abstract: A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.Type: GrantFiled: March 5, 2015Date of Patent: October 29, 2019Assignee: NuvOx Pharma LLCInventor: Evan C. Unger
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Patent number: 10456469Abstract: The present invention is a glutamine compound having a non-radioisotope high Z element attached via a linker, which enters the mitochondrion and is subsequently exposed to ionizing radiation. When exposed to ionizing radiation, the present invention damages mitochondrial (as well as other) substructures such as mtDNA, the outer membrane, the inner membrane, cristae, ribosomes, etc., and causes the effective destruction of such mitochondrion. Tumorigenic cells without mitochondria cannot produce the energy they need to subsist and replicate, effectively starving them of energy and causing their destruction.Type: GrantFiled: March 3, 2017Date of Patent: October 29, 2019Assignee: SERBIG PHARMACEUTICALS CORP.Inventor: Pedro Anastacio Serrano-Ojeda
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Patent number: 10456470Abstract: The invention provides methods and compositions to detect expression of one or more biomarkers for identifying and treating patients having glioblastomas who are likely to be responsive to VEGF antagonist therapy. The invention also provides kits and articles of manufacture for use in the methods.Type: GrantFiled: August 28, 2014Date of Patent: October 29, 2019Assignee: Genentech, Inc.Inventors: Carlos Bais, Richard Bourgon, Heidi Phillips, Thomas Sandmann
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Patent number: 10456471Abstract: Disclosed herein are compositions comprising an NSAID such as meloxicam in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability, solubility, or pharmacokinetics of the NSAID for the treatment of conditions such as pain.Type: GrantFiled: May 3, 2019Date of Patent: October 29, 2019Assignee: AXSOME THERAPEUTICS, INC.Inventor: Herriot Tabuteau
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Patent number: 10456472Abstract: The present invention provides phenylalkylcarboxylic acid compounds and compositions containing such compounds which facilitate the delivery of biologically active agents.Type: GrantFiled: June 30, 2016Date of Patent: October 29, 2019Assignee: EMISPHERE TECHNOLOGIES, INC.Inventors: David Gschneidner, Stephen V. Pusztay
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Patent number: 10456473Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).Type: GrantFiled: May 12, 2017Date of Patent: October 29, 2019Assignee: Arbutus Biopharma CorporationInventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Michael E. Jung
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Patent number: 10456474Abstract: A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.Type: GrantFiled: March 2, 2015Date of Patent: October 29, 2019Assignee: Saint Regis Mohawk TribeInventors: James N. Chang, Orest Olejnik, Bruce A. Firestone
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Patent number: 10456475Abstract: Cell penetrating peptides (CPPs) are established as a strategy to move cargoes into the interior of eukaryotic cells by engaging import machinery on the cell surface. In most cases the CPP is covalently linked to the cargo; it is common to express cargo proteins with a CPP extension. In some experiments a non-specific interactions (e.g., hydrophobic interactions) have been used to form CPP-cargo complexes, but this has numerous drawbacks. Transport is less efficient and the lack of specificity means that other macromolecules in the medium will also be internalized. This application describes the use of specific CPP labeled adaptor proteins that can be used to move a wide variety of cargoes into the cell interior. The prototype adaptor protein is calmodulin; it is small, stable and easily produced, and binds short (17 amino acid) targets with high affinity in the presence of calcium. A cargo produced with a calmodulin binding tag can be internalized efficiently by CPP tagged calmodulin.Type: GrantFiled: February 3, 2015Date of Patent: October 29, 2019Assignee: Kennsaw State University Research and Service Foundation, Inc.Inventor: John C. Salerno
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Patent number: 10456476Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.Type: GrantFiled: November 8, 2017Date of Patent: October 29, 2019Assignee: Nektar TherapeuticsInventor: Antoni Kozlowski
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Patent number: 10456477Abstract: The present technology relates generally to oligolactic acid conjugates of paclitaxel, rapamycin, selumetinib, and other anticancer agents, micelle compositions containing such conjugates and methods of preparing and using such compositions to treat various cancers. Specifically, there are provided oligolactic acid conjugates wherein the oligolactic acid comprises 2 to 24 lactic acid subunits and is attached through an ester linkage to the oxygen of the 7-hydroxyl of the paclitaxel or paclitaxel derivative, the 40-hydroxyl of the rapamycin or rapamycin derivative, and the 2?-hydroxyl of the selumetinib or selumetinib derivative. Compositions comprising water and a micelle comprising a polylactic acid-containing polymer and the oligolactic acid conjugate may be readily prepared. Methods of inhibiting or killing cancer cells and treating paclitaxel, rapamycin, and/or selumetinib cancers are also provided.Type: GrantFiled: March 13, 2017Date of Patent: October 29, 2019Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: Glen S. Kwon, Yu Tong Tam
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Patent number: 10456478Abstract: Provided herein is chitosan dually derivatized with arginine and gluconic acid; and methods of making and using the same, e.g., for gene delivery in vivo.Type: GrantFiled: April 17, 2017Date of Patent: October 29, 2019Inventors: Jun Gao, Eric Hsu, Anthony Cheung
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Patent number: 10456479Abstract: Hydrophilic linkers are useful for linking drugs to cell-binding ligands in ligand-drug conjugates, such as antibody-drug conjugates. The ligand-drug conjugate includes a cell-binding ligand capable of binding to a particular cell population, and a drug connected to the ligand by a hydrophilic linker. The hydrophilic linker includes one or more hydrophilic groups that render the linker hydrophilic. The hydrophilic linker may also include functional groups at the two termini for coupling to the drug and the cell-binding ligand respectively.Type: GrantFiled: March 19, 2015Date of Patent: October 29, 2019Assignee: HANGZHOU DAC BIOTECH CO., LTD.Inventors: Sanxing Sun, Robert Yongxin Zhao, Xing Li, Huihui Guo, Junxiang Jia, Hongsheng Xie, Xiaomai Zhou, Yuanyuan Huang, Qingliang Yang, Xiaotao Zhuo, Hangbo Ye, Shun Gai, Lan Qu, Wenjun Li, Chen Lin
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Patent number: 10456480Abstract: This document provides methods and materials related to treating glaucoma, ocular hypertension, cardiovascular diseases, and renal diseases. For example, this document provides isolated nucleic acid molecules and viral vectors (e.g., lentiviral vectors) containing isolated nucleic acid molecules. Methods for reducing intraocular pressure as well as symptoms and progression of cardiovascular and renal diseases also are provided.Type: GrantFiled: July 30, 2018Date of Patent: October 29, 2019Assignee: Mayo Foundation for Medical Education and ResearchInventors: Eric M. Poeschla, Roman A. Barraza
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Patent number: 10456481Abstract: Provided herein is chitosan-derivative nanoparticle comprising chitosan functionalized with a cationic amino acid and a hydrophilic polyol; and methods of making and using same, e.g., for gene delivery in vivo.Type: GrantFiled: August 10, 2018Date of Patent: October 29, 2019Inventors: Jun Gao, Eric Hsu, Anthony Cheung
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Patent number: 10456482Abstract: The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.Type: GrantFiled: June 15, 2017Date of Patent: October 29, 2019Assignee: On Target Laboratories, LLCInventors: Sumith A. Kularatne, Pravin Gagare
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Patent number: 10456483Abstract: Acoustically responsive stabilized microbubbles formulated with a phospholipid monolayer shell, an encapsulated bioactive gas, and an encapsulated perfluorocarbon gas of the formula CxFy in a volume ratio of from about 10:1 to about 1:10, wherein X is greater than or equal to 3, are disclosed. Also provided are methods for promoting localized vasodilation in a patient in need thereof by delivering a microbubble comprising a phospholipid monolayer shell and an encapsulated bioactive gas locally to a target diseased section of the patient's vasculature; and releasing the bioactive gas at the target diseased section, wherein the microbubble comprises the bioactive gas in a ratio of from about 10:1 to about 1:10 by volume with a perfluorocarbon gas.Type: GrantFiled: October 19, 2017Date of Patent: October 29, 2019Assignee: University of CincinnatiInventors: Christy Holland, Himanshu Shekhar, Arunkumar Palaniappan
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Patent number: 10456484Abstract: Disclosed is a steam sterilizer, and a single use/disposable container for use in the sterilizer and a sterilization method. The container is a rigid or semi-rigid container having a sealable elongate conduit through which steam sterilant may be introduced into the container and steam sterilant and condensate may be removed from the container. Once one or more items to be sterilized are placed in the container a cover is sealed over the mouth of the container. The steam sterilizer has a sterilization chamber adapted to receive the container and provide sterilant within and around the container. Sterilant is provided to the container via the conduit which is sealed at the end of the sterilization process.Type: GrantFiled: September 11, 2015Date of Patent: October 29, 2019Assignee: MERCER TECHNOLOGIES LIMITEDInventors: Terry Dean Kemp, Alan Reg Dowman
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Patent number: 10456485Abstract: A lighting device configured to deactivate dangerous pathogens (e.g., MRSA bacteria) in an environment. The lighting device includes at least one lighting element with a single light source configured to provide light. At least a first component of the light comprising light having a wavelength of about 405 nm, and at least a second component of the light comprising light having a wavelength of greater than 420 nm. The first component of light has a minimum integrated irradiance of 0.01 mW/cm2 measured from any unshielded point in the environment that is 1.5 m from any point on any external-most luminous surface of the lighting device.Type: GrantFiled: April 12, 2017Date of Patent: October 29, 2019Assignee: KENALL MANUFACTURING COMPANYInventors: James W. Hawkins, Nathan D. Heiking
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Patent number: 10456486Abstract: A solution for generating ultraviolet diffusive radiation is provided. A diffusive ultraviolet radiation illuminator includes at least one ultraviolet radiation source located within a reflective cavity that includes a plurality of surfaces. At least one of the plurality of surfaces can be configured to diffusively reflect at least 70% of the ultraviolet radiation and at least one of the plurality of surfaces can be configured to transmit at least 30% of the ultraviolet radiation and reflect at least 10% of the ultraviolet radiation.Type: GrantFiled: December 22, 2017Date of Patent: October 29, 2019Assignee: Sensor Electronic Technology, Inc.Inventors: Saulius Smetona, Alexander Dobrinsky, Yuri Bilenko, Michael Shur
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Patent number: 10456487Abstract: An ultraviolet illuminator for providing a cleaning treatment to a medical device is disclosed. The ultraviolet illuminator can include an ultraviolet cleaning treatment system that operates in conjunction with at least one ultraviolet radiation source and sensor to clean surfaces of a medical device for purposes of disinfection, sterilization, and/or sanitization. The ultraviolet illuminator is suitable for a wide variety of medical devices, instruments and equipment. Stethoscopes and medical instrument probes are illustrative examples of some devices that can be used with the ultraviolet illuminator.Type: GrantFiled: June 4, 2018Date of Patent: October 29, 2019Assignee: Sensor Electronic Technology, Inc.Inventors: Yuri Bilenko, Timothy James Bettles, Alexander Dobrinsky, Michael Shur
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Ultraviolet transparent structure for ultraviolet illumination using scattered and focused radiation
Patent number: 10456488Abstract: A solution for disinfecting an ultraviolet transparent structure and/or an item placed on or near the structure is provided. The solution can utilize a set of ultraviolet radiation sources configured to generate ultraviolet radiation through the internal surface of the ultraviolet transparent structure towards the external surface and out to an ambient environment for disinfection of the external surface and/or a targeted item. A first set of sources can generate a scattered type of radiation that uniformly disinfects the external surface of the ultraviolet transparent structure and a second set of sources can generate a focused type of radiation that disinfects at least one portion of the targeted item. A control system can direct the first set of sources to generate the scattered radiation towards the external surface of the ultraviolet transparent structure and direct the second set of sources to generate the focused radiation at the targeted item.Type: GrantFiled: September 26, 2018Date of Patent: October 29, 2019Assignee: Sensor Electronic Technology, Inc.Inventors: Yuri Bilenko, Alexander Dobrinsky, Michael Shur -
Patent number: 10456489Abstract: Provided is a decontamination cover to be applied over an object to be decontaminated. The decontamination cover includes a sheet-like body formed from a pliable material, and includes an outward-facing surface that is substantially opaque to UVC light and an inward-facing surface that is to be arranged opposite a surface of the object to be decontaminated. A plurality of UVC sources are exposed at the inward-facing surface, and a plurality of spacers are arranged among the UVC sources to maintain a suitable separation between the UVC sources and the surface of the object to be decontaminated. This suitable separation promotes complete coverage of the surface with UVC light emitted by the UVC sources.Type: GrantFiled: October 8, 2018Date of Patent: October 29, 2019Assignee: Diversey, Inc.Inventor: Roderick M. Dayton
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Patent number: 10456490Abstract: A method of sterilizing an object with atomic nitrogen from a nitrogen plasma comprises the steps of positioning the object in a sterilization chamber, and conditioning the object present in the chamber. The step of conditioning includes a first stage of injecting atomic nitrogen into the chamber, during which a first concentration of atomic nitrogen in the chamber is imposed, a suction stage performed after the first injection stage, during which the chamber is evacuated, and a second stage of injecting atomic nitrogen into the chamber that is performed after the suction stage, during which a second concentration of atomic nitrogen is imposed in the chamber. The method further comprises a sterilization step of sterilizing the object, performed after the conditioning, and includes injecting atomic nitrogen into the chamber, during which step a concentration of atomic nitrogen in the chamber is imposed that is greater than the first and second concentrations.Type: GrantFiled: December 5, 2017Date of Patent: October 29, 2019Assignee: Societe Pour La Conception Des Applications Des Techniques ElectroniquesInventors: Sandrine Villeger, Marie-Agnès Benoit
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Patent number: 10456491Abstract: A method of sterilizing an object with atomic nitrogen from a nitrogen plasma includes the steps of placing the object in a sterilization chamber and a sterilization half-cycle for sterilizing the object present in the chamber. The sterilization half-cycle comprises an alternation between stages of injecting atomic nitrogen into the chamber and of intermediate stages, each intermediate stage including at least one suction stage during which the chamber is evacuated.Type: GrantFiled: December 5, 2017Date of Patent: October 29, 2019Assignee: Societe Pour La Conception Des Applications Des Techniques ElectroniquesInventors: Sandrine Villeger, Marie-Agnès Benoit, Pascal Regere
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Patent number: 10456492Abstract: Technologies for sanitizing a medical instrument with ozone are described. In particular, systems, methods, and devices for sanitizing a continuous positive airway pressure (CPAP) device are disclosed. The systems and device include an ozone compartment, an ozone operating system and one or more ozone distribution lines that distribute ozone to a continuous positive airway pressure device. The device may further include a heater adapter unit to connect heating systems in CPAP devices while distributing ozone to sanitize the CPAP device.Type: GrantFiled: January 25, 2019Date of Patent: October 29, 2019Assignee: SoClean, Inc.Inventor: Timothy Leyva
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Patent number: 10456493Abstract: An apparatus is provided for controlling hospital acquired infections by targeting critical control points for pathogen transfer. An infection control apparatus comprises an asset tagging unit; a spraying unit; a power supply unit; optionally a DNA/RNA sequencing unit; and a computing unit comprising a non-transitory computer-readable medium encoded with program instructions for controlling the asset tagging unit and the spraying unit to perform a method of infection control in the facility. In general, the apparatus is used to identify which assets are critical control points for pathogen transfer and to treat those assets with a residual self-sanitizing coating.Type: GrantFiled: June 20, 2018Date of Patent: October 29, 2019Assignee: Allied Bioscience, Inc.Inventors: Craig Grossman, Ingrida Grossman, Gavri Grossman
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Patent number: 10456494Abstract: A system for storing instruments is provided. The system includes a tray including at least one tray end. At least one slot is formed in the at least one tray end. The system also includes a cover constructed and arranged to be positioned on the tray. The cover includes at least one cover end. The system also includes a latch positioned within the at least one cover end. The latch includes an actuating member and a locking member. The locking member includes at least one locking flange constructed and arranged to be received in the at least one slot. The at least one locking flange includes an angled lower edge constructed and arranged to engage the at least one tray end when the cover is positioned on the tray so that the latch is actuated into an open position to enable the at least one locking flange to be received within the at least one slot.Type: GrantFiled: February 9, 2016Date of Patent: October 29, 2019Assignee: Estes Design and Manufacturing, Inc.Inventors: H. Richard Roudebush, Jay Vance Engh, Carl Ryan Estes, Ronald C. Estes
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Patent number: 10456495Abstract: A packaging device including a receiving compartment for medical products to be sterilized or having been sterilized, the receiving compartment being sealable in a sterile manner; a carrier for hanging and/or guiding and/or handling the packaging device, wherein the carrier extends into the interior of the receiving compartment and includes at least one accurately fitting mount for a section of a medical product to be sterilized or having been sterilized. Also, secondary packaging for accommodating a plurality of such packaging devices.Type: GrantFiled: June 5, 2017Date of Patent: October 29, 2019Assignee: B. Braun Melsungen AGInventors: Ralph Geiger, Peter Van Venrooy-Markefka
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Patent number: 10456496Abstract: A disinfecting vanity mirror includes a substantially enclosed cabinet having top, a bottom, side and rear walls and a mirror panel as the front wall when mounted to form an enclosed space or chamber. The top and bottom walls include passageways to allow vertical air flow through the enclosed space to allow air to enter through the bottom wall to rise and exit through the top wall. Sources of UV light are provided both within and below the cabinet to sanitize the air moving upwardly through the plenum space and below the vanity mirror to expose interior surfaces and exterior surfaces below the cabinet such as sinks and countertops. A controller is programmed to interrupt or discontinue the generation of UV light when a motion detector senses motion in proximity to the mirror and/or in accordance with a programmed sequence of on and off times.Type: GrantFiled: October 29, 2018Date of Patent: October 29, 2019Assignee: SteriLumen, Inc.Inventor: Max Munn
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Patent number: 10456497Abstract: A dressing for use in protectively covering and isolating a medical device placed on and/or through the skin surface of a patient is disclosed. Examples of such devices include infusion needles for accessing subcutaneously implanted access ports, catheters of various types and purposes, insulin infusion needles, etc. In one embodiment, a dressing for covering a medical device on a skin surface of a patient is disclosed and comprises a dressing portion that is configured to rest against a skin surface of a patient, with the dressing portion defining a hole, and a polymeric cover film that is at least indirectly attached to the dressing portion. The cover film includes a pliable domed portion aligned with the hole of the dressing portion. The pliable domed portion defines a cavity that is configured to receive therein the medical device when the dressing is placed on the skin of the patient.Type: GrantFiled: September 10, 2015Date of Patent: October 29, 2019Assignee: C. R. Bard, Inc.Inventors: Glade H. Howell, Kelly J. Christian, Matthew W. Bown
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Patent number: 10456498Abstract: Adhesive compositions exhibiting antimicrobial properties, good stability, long shelf lives and enhanced release of antimicrobial agents are described. In certain versions, the compositions also exhibit relatively high fluid handling capacities. The adhesive compositions inhibit microbial growth by more than 2 log after 24 hours contact and particularly more than 3.5 log after 6 hours contact. Also described are various medical articles using such adhesives and related methods.Type: GrantFiled: February 7, 2014Date of Patent: October 29, 2019Assignee: Avery Dennison CorporationInventor: Anne M. Wibaux
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Patent number: 10456499Abstract: Adhesive articles suitable for use in medical applications include a siloxane-based pressure sensitive adhesive layer, and a breathable conformable backing having a first surface and a second surface. The siloxane-based pressure sensitive adhesive layer is coated on the first surface of the breathable conformable backing, and the second surface of the breathable conformable backing comprises a treated surface. The siloxane-based pressure sensitive adhesive layer can be attached to skin and other adhesive articles can be releasably adhered to the treated surface to form adhesive constructions.Type: GrantFiled: May 16, 2013Date of Patent: October 29, 2019Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: Simon S. Fung, David T. Amos, Junkang J. Liu, Timothy M. Dietz, Jing Ma, Charles W. Opp
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Patent number: 10456500Abstract: A new preparation for regenerating tissues or healing wounds, which can be administered to a patient, which comprises serum and globin being insoluble at physiological pH, said preparation being obtained by adding said serum to said globin being insoluble at physiological pH.Type: GrantFiled: March 18, 2014Date of Patent: October 29, 2019Assignee: KHORIONYXInventors: Jean-Louis Tayot, Jean Bernasconi
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Patent number: 10456501Abstract: Provided herein are methods and compositions for cardiac therapy. Such compositions include extracellular-matrix (ECM)-based products that can be used to support tissue repair. The compositions can be used for various purposes. In some cases, they can be introduced into a subject in order to preserve and/or repair damaged heart tissue.Type: GrantFiled: September 18, 2017Date of Patent: October 29, 2019Assignee: Ventrix, Inc.Inventors: Karen Christman, Jennifer Singelyn, Jessica Dequach
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Patent number: 10456502Abstract: A method of recovering progenitor cells from bone marrow aspirate. A bone void filler preparation container is provided. The bone void filler preparation container has an inlet port and an outlet port. A bone graft matrix having a particle size of between about 1,000 ?m and about 2,000 ?m is placed in the bone void filler preparation container. A bone marrow aspirate is passed through the bone void filler preparation container. Progenitor cells in the bone marrow aspirate are retained in the bone void filler preparation container. A selection ratio of the progenitor cells retained in the bone void filler preparation container to a total number of nucleated cells retained in the bone void filler preparation container is greater than about 3.Type: GrantFiled: September 7, 2017Date of Patent: October 29, 2019Assignees: Fortus Medical, Inc., The Cleveland Clinic FoundationInventors: Robert Assell, Andrew Freeman, George Muschler
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Patent number: 10456503Abstract: A polymer laminate has 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm that are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. A polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.Type: GrantFiled: April 20, 2015Date of Patent: October 29, 2019Assignees: Toray University Educational System, Toray Industries, Inc.Inventors: Yosuke Okamura, Yu Nagase, Takuya Komachi, Motonori Hochi, Yuki Sekido, Toru Arakane
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Patent number: 10456504Abstract: An acicular body includes a support plate having a brightness of 5.0 or less, and a needle disposed on the support plate. The needle includes a tip formed to pierce a skin and a light transmission area which is located in an area including the tip and has a total light transmittance of 20% or more.Type: GrantFiled: January 21, 2016Date of Patent: October 29, 2019Assignee: TOPPAN PRINTING CO., LTD.Inventors: Hiroyuki Kato, Takako Yamamoto
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Patent number: 10456505Abstract: The present invention relates to extravascular supports. In particular, to extravascular supports which are used in vein grafting. More in particular, it relates to extravascular supports which are biodegradable.Type: GrantFiled: January 6, 2017Date of Patent: October 29, 2019Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventor: Jacob Laurens Koopman
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Patent number: 10456506Abstract: The present invention relates to pore-free polymer tubes and prefers bio-resorbable pore-free polymer tubes prepared from at least one polymer filament, wherein the at least one polymer filament has a diameter of ?50 ?m and the at least one polymer filament is melted pore-free, as well as the methods to prepare these polymer tubes, which are especially useful for the production of stents.Type: GrantFiled: December 15, 2014Date of Patent: October 29, 2019Assignee: MEKO LASERSTRAHL-MATERIALBEARBEITUNGEN E.K.Inventors: Jakob Dohse, Bernd Hinrichs
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Patent number: 10456507Abstract: A tissue fusion agent includes a supporting element and a flock material. A surgical system includes the tissue fusion agent and a tissue fusion instrument. A method of producing the tissue fusion agent includes a) coating a supporting element with an adhesive, and b) flocking the adhesive-coated supporting element with a flock material while the adhesive is moist, adhesive or tacky, or after activation of the adhesive.Type: GrantFiled: March 5, 2014Date of Patent: October 29, 2019Assignee: Aesculap AGInventors: Christof Merckle, Erich Odermatt
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Patent number: 10456508Abstract: An improvement in drug-eluting stents, and method of their making, are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 ?in (0.5 ?m) and a surface roughness range of between about 300-700 ?in (7.5-17.5 ?m). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.Type: GrantFiled: January 13, 2017Date of Patent: October 29, 2019Assignee: Biosensors International Group, Ltd.Inventors: Douglas R. Savage, John E. Shulze, Ronald E. Betts, Sepehr Fariabi, Shih-Horng Su
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Patent number: 10456509Abstract: Compositions containing chlorhexidine gluconate solubilized in hydrophobic vehicles are described. Resin systems containing such chlorhexidine gluconate compositions, including adhesives and articles incorporating such resin systems, including medical articles such as drapes are also described.Type: GrantFiled: January 31, 2019Date of Patent: October 29, 2019Assignee: 3M Innovative Properties CompanyInventors: Vinod P. Menon, Joseph D. Rule, Richard B. Ross, Deena M. Conrad-Vlasak, Katie F. Wlaschin
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Patent number: 10456510Abstract: The disclosed devices and methods provide for the minimization of fluid extravasation during use of infusion catheters such as peripherally inserted central catheters and central venous catheters. The anti-extravasation catheter allows a surgeon to drain fluids from soft tissue surrounding an infusion site while also providing fluid inflow to a patient.Type: GrantFiled: February 11, 2014Date of Patent: October 29, 2019Assignee: Cannuflow, Inc.Inventor: Theodore R. Kucklick
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Patent number: 10456511Abstract: The device (10, 36, 38, 42, 68) applies a negative pressure to an endoluminal surface in the body of a patient to facilitate healing of a wound in the endoluminal surface. The device comprises a flexible porous element (14) with a peripheral outer face (32) for contact with the wound, the outer face being defined between opposite proximal and distal ends of the porous element. A suction tube (30) for being connected to a suction source externally of the patient's body is provided in fluid communication with the porous element to apply a negative pressure to the wound via the outer face (32) of the porous element (14) upon operation of the suction source. The porous element (14) has at least one through passageway (16) extending from its proximal end to its distal end for passage of bodily substances of the patient through the porous element.Type: GrantFiled: June 10, 2016Date of Patent: October 29, 2019Inventor: Daniel Eduard Kleiner
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Patent number: 10456512Abstract: A baby product sterilizer having a breast pump includes: a body having a cap disposed openably and closably on the front surface thereof and a plurality of ultraviolet lamps located at the inside thereof to sterilize and dry baby products accommodated therein; a cover located at outer surfaces of the body; and the breast pump disposed between the body and the cover in such a manner as to be controlled by a controller mounted on the cover.Type: GrantFiled: November 3, 2015Date of Patent: October 29, 2019Assignee: CIMILRE CO., LTD.Inventor: Sang Ha Kim
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Patent number: 10456513Abstract: A blood pump system is implantable in a patient for ventricular support. A pumping chamber has an inlet for receiving blood from a ventricle of the patient. An impeller is received in the pumping chamber. A motor is coupled to the impeller for driving rotation of the impeller. A motor controller is provided for tracking systolic and diastolic phases of a cardiac cycle of the patient and supplying a variable voltage signal to the motor in a variable speed mode to produce a variable impeller speed linked to the cardiac cycle. The impeller speed comprises a ramping up to an elevated speed during the diastolic phase in order to reduce a load on the ventricle at the beginning of the systolic phase.Type: GrantFiled: June 30, 2017Date of Patent: October 29, 2019Assignee: TC1 LLCInventors: Alexander Medvedev, Masamichi Yanai
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Patent number: 10456514Abstract: A device for providing assistance to ventricular systole, the device comprising a pressuriser and a driver, wherein the pressuriser is adapted to be able to apply localised pressure to only the external wall of one ventricle, or a portion thereof, and the driver is operatively linked to the pressuriser so as to be able to drive a cycle of increased and decreased pressure applied by the pressuriser. The invention also relates to a method of implanting the device and a method of treating cardiac pump failure in which the device is used.Type: GrantFiled: April 1, 2016Date of Patent: October 29, 2019Assignee: University of LeicesterInventors: David Adlam, Samara-Ratna Piyal
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Patent number: 10456515Abstract: A wearable ultrafiltration apparatus is provided. The apparatus can include a first ultrafilter for filtering a patient's blood along a first fluid path and a second ultrafilter for filtering the patient's blood along a second fluid path. The apparatus can also include a valve being positionable in a first position for directing the patient's blood along the first fluid path. The valve can also be positioned in a second position for directing the patient's blood along the second fluid path. When the valve is in the first position, blood can flow along the first fluid path and prevent blood from flowing along the second fluid path. When the valve is in the second position, blood can flow along the second fluid path and prevent blood from flowing along the first fluid path. When the valve is in the first position, the second ultrafilter can be idle and capable of being serviced or replaced and when the valve is in the second position, the first ultrafilter can be idle and capable of being serviced or replaced.Type: GrantFiled: August 8, 2018Date of Patent: October 29, 2019Assignee: The Trustees of Columbia University in the City of New YorkInventors: Robert J. von Gutfeld, Arthur Autz, Edward F. Leonard, Stanley Cortell