Patents Issued in November 19, 2019
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Patent number: 10478521Abstract: A sheet material that can be used as a wound dressing and contains elemental metal particles.Type: GrantFiled: February 26, 2013Date of Patent: November 19, 2019Assignee: aap Implantate AGInventors: Marco Wolfstaedter, Birgit Schaefer
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Patent number: 10478522Abstract: More specifically, granules made of biocompatible metal material, preferably osteoinductive metal, for use in vertebroplasty surgery, as well as the use of these granules for this purpose, are the object of the present invention.Type: GrantFiled: July 17, 2015Date of Patent: November 19, 2019Assignee: MT ORTHO S.R.L.Inventors: Natale Francaviglia, Gaetano Sorano, Roberto Drago
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Patent number: 10478523Abstract: A composition comprising Polyhydroxyurethanes, Glycosaminoglycans, hydrolysed glycosaminoglycans, glycosamines of glycosaminoglycans, chemically modified or not and a Protein or a peptide; said protein being collagen, elastin, keratin, fibronectin, actin, myosin, laminin, a peptide or a blend of those proteins or peptides, fibrillated, hydrolysed, chemically modified or not. This homogenous composition is obtained by the polymerisation or the covalent bounding of two preparations containing cyclic polycarbonates, polyamines, glycosaminoglycans, hydrolysed glycosaminoglycans, glycosamines, chemically modified or not and proteins or peptides or a blend of those proteins or peptides, fibrillated, hydrolysed, chemically modified or not.Type: GrantFiled: September 4, 2015Date of Patent: November 19, 2019Assignee: ChondroNest SAInventor: Thierry Schwitzguébel
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Patent number: 10478524Abstract: This invention relates to a lamellae tissue layer, comprising a grooved silk fibroin substrate comprising tissue-specific cells. The silk fibroin substrates provides an excellent means of controlling and culturing cell and extracellular matrix development. A multitude of lamellae tissue layers can be used to create a tissue-engineered organ, such as a tissue-engineered cornea. The tissue-engineered organ is non-immunogenic and biocompatible.Type: GrantFiled: May 19, 2017Date of Patent: November 19, 2019Assignee: TRUSTEES OF TUFTS COLLEGEInventors: David L. Kaplan, Fiorenzo G. Omenetto, Jeffrey K. Marchant, Noorjahan Panjwani, Brian Lawrence
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Patent number: 10478525Abstract: A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.Type: GrantFiled: July 29, 2015Date of Patent: November 19, 2019Assignee: BACTERIN INTERNATIONAL, INC.Inventors: Nancy J. Shelby, Steven M. Scott, Benjamin P. Luchsinger, Gregory A. Juda, Kelly R. Kirker, Darrel L. Holmes, Jesus Hernandez
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Patent number: 10478526Abstract: This invention provides compositions in the form of skin substitutes comprising epithelial cells and mesenchymal cells, wherein the mesenchymal cells are not isolated from the occipital or nape region of the scalp, as well as methods for using the same.Type: GrantFiled: May 1, 2014Date of Patent: November 19, 2019Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Rajesh Thangapazham, Thomas N. Darling, Shaowei Li
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Patent number: 10478527Abstract: This invention relates to biodegradable implants comprising a hydrogel carrier matrix having dispersed therein a multitude of particles, wherein each of the multitude of particles and/or the hydrogel carrier matrix includes an active pharmaceutical ingredient (API) for the treatment of transected peripheral nerve injuries. Each of the multitude of particles and/or the hydrogel carrier matrix includes pristine polymer particles, preferably the pristine polymer particles may be polymethylmethacrylate polymers and derivatives thereof, preferably poly(methacrylic-co-methyl methacrylate) (PMMA). The spheroidal particles may each be formed from an outer shell including a chitosan (CHT) poly(methacrylic-co-methyl methacrylate) (PMMA) polyelectrolyte complex (CHT-PMMA-PEC) and an inner core including crosslinked chitosan having dispersed therein PMMA nanoparticles.Type: GrantFiled: September 5, 2016Date of Patent: November 19, 2019Assignee: University of the Witwatersrand, JohannesburgInventors: Viness Pillay, Yahya Essop Choonara, Pradeep Kumar, Lisa Claire Du Toit, Poornima Ramburrun
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Patent number: 10478528Abstract: Synthetic, bioactive ultra-porous bone graft materials having an engineered porosity, and implants formed from such materials are provided. In particular, these implants comprise bioactive glass and incorporate allograft material for osteoinduction. The implants are suitable for bone tissue regeneration and/or repair.Type: GrantFiled: July 1, 2016Date of Patent: November 19, 2019Assignee: PROSIDYAN, INC.Inventors: Charanpreet S. Bagga, Steven B. Jung, Hyun W. Bae
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Patent number: 10478529Abstract: An alloy and an implant having a three-dimensional structure based on such alloy. The alloy comprises a MgZnCa alloy containing nanosized precipitates being less noble than the Mg matrix alloy and having a Zn content ranging 0.1 wt. % Zn to 2 wt. % Zn and a calcium content ranging from 0.2 wt. % to 0.5 wt. %, and having one or more other elements, with the remainder being Mg. Any second phase generated during the solidification process may be completely dissolved by a solution heat treatment. Finely dispersed nanosized precipitates can then be generated by a subsequent aging heat treatment step. These precipitates are used to “pin” the grain boundaries and to prevent the coarsening of the grain structure during further processing to achieve grain sizes below 5 ?m.Type: GrantFiled: March 11, 2014Date of Patent: November 19, 2019Assignee: DePuy Synthes Products, Inc.Inventors: Thomas Imwinkelried, Stefan Beck, Peter Uggowitzer, Joerg Loeffler
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Patent number: 10478530Abstract: This invention discloses method of manufacture of balloon expandable stent made from bioabsorbable polymer with thin struts (strut thickness 130 ?m or less, preferably 100-110 ?m) with high fatigue and radial strength. The invention further discloses balloon expandable stent made from bioabsorbable polymer with thin struts (strut thickness 130 ?m or less, preferably 100-110 ?m) with high fatigue and radial strength.Type: GrantFiled: November 20, 2014Date of Patent: November 19, 2019Assignee: MERIL LIFE SCIENCES PVT. LTD.Inventors: Rajnikant Gandalal Vyas, Pramod Kumar Minocha, Deveshkumar Mahendralal Kothwala
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Patent number: 10478531Abstract: This document provides methods and materials for treating a mammal (e.g., a human) having one or more stenotic blood vessels. For example, amnion coated balloons that can be used in balloon angioplasty are provided.Type: GrantFiled: September 19, 2017Date of Patent: November 19, 2019Inventor: Gary M. Petrucci
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Patent number: 10478532Abstract: A surgical hand piece is described that maintains a vacuum pressure within the hand piece at a selected level. A check valve is provided substantially near an inlet of an integrated aspirating pump. The check valve opens to introduce fluid into the hand piece to maintain the vacuum pressure within the hand piece at or above the selected level so as to prevent or substantially reduce post-occlusion flow.Type: GrantFiled: December 15, 2017Date of Patent: November 19, 2019Assignee: Alcon Research, Ltd.Inventors: Glenn Robert Sussman, Mikhail Boukhny, John Morgan Bourne
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Patent number: 10478533Abstract: Embodiments of the present invention relate to the field of pressurized fluid delivery devices for use in medical procedures. In particular, a fluid delivery pump comprises at least one compressive member configured to apply a force to a fluid reservoir. The at least one compressive member is associated with a flexible envelope, such that the flexible envelope may move the compressive member. The flexible envelope may be substantially air-tight so that it may be pressurized. When a negative pressure is created inside the flexible envelope, the flexible envelope may change volume, applying a force to the at least one compressive member. The at least one compressive member may then apply a force to the fluid reservoir and the fluid is forced out of the reservoir.Type: GrantFiled: June 24, 2017Date of Patent: November 19, 2019Assignee: Megadyne Medical Products, Inc.Inventors: Paul R. Borgmeier, Darcy W. Greep, Shawn K. Horner, Chad S. Frampton
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Patent number: 10478534Abstract: Methods and apparatuses for automatically switching different aspiration levels to an ocular probe are disclosed herein. The probe may be a phacoemulsification probe. A first aspiration level, supplied by a first pump, may be applied to the probe simultaneously with ultrasonic energy. A second aspiration level, supplied by a second pump, may be automatically switched from the first aspiration level. Control feed back of the pumps may be varied according to set thresholds.Type: GrantFiled: February 10, 2017Date of Patent: November 19, 2019Assignee: Johnson & Johnson Surgical Vision, Inc.Inventors: Robert G. Raney, Michael J. Claus, James Gerg, Wayne S. Wong, David A. King, James W. Staggs, Fred Lee
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Patent number: 10478535Abstract: A suction catheter system is described with a suction extension interfaced with a guide catheter to form a continuous suction lumen extending through a portion of the guide catheter and through the suction extension. The suction extension can be positioned by tracking the suction nozzle through a vessel while moving a proximal portion of the suction extension within the lumen of the guide catheter. The suction extension can comprise a connecting section with a non-circular cross section for interfacing with the inner lumen of an engagement section of the guide catheter. The tubular body of the guide catheter can have a reduced diameter distal section the can be useful to restrain the movement of the suction extension.Type: GrantFiled: May 24, 2017Date of Patent: November 19, 2019Assignee: MIVI Neuroscience, Inc.Inventor: Matthew F Ogle
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Patent number: 10478536Abstract: In one example embodiment, an apparatus may include a panel with integrated fluid channels, wherein the panel and the fluid channel consist only of surfaces that can be manufactured with a straight-pull mold. A port may also be integrated into the panel to facilitate coupling the fluid channel to pneumatic components in an assembly. A seal may be secured to the panel over the fluid channel to form an integrated fluid conductor. The seal is preferably an adhesive label that can also be used for product labeling. Such an apparatus may be used in a control unit of a therapy system, employing several integrated fluid conductors. A method of manufacturing may include molding a panel, wherein the mold forms a channel integral to the panel. The panel and the channel preferably consist of surfaces that can be molded with a straight-pull mold.Type: GrantFiled: September 9, 2015Date of Patent: November 19, 2019Assignee: KCI Licensing, Inc.Inventors: Benjamin Andrew Pratt, James Killingworth Seddon, Christopher Brian Locke, David Mercer, Loren Francis
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Patent number: 10478537Abstract: An object of the present invention is to provide a novel filter material and a filter including the same. Specifically, the present invention aims to provide a filter material capable of filtering in a short period of time, without clogging of the filter, while maintaining high cell separation properties, and a filter including the same. More specifically, the present invention aims to provide a filter material in which fiber masses (flocs) are uniformly distributed, and a filter including the same. The present invention provides a novel filter material showing excellent cell separation properties and excellent flow-through properties regardless of design choices for filters known prior to the filing of the present application, and an efficient cell separation method using a novel filter on which the filter material is stacked.Type: GrantFiled: October 7, 2014Date of Patent: November 19, 2019Assignee: KANEKA CORPORATIONInventors: Ikuhiro Suzuki, Takayuki Miyamoto, Takao Shibata
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Patent number: 10478538Abstract: The invention relates to a flexible catheter (1) with a drive shaft (2), with a sleeve (6) surrounding the drive shaft (2) and with a sheath (7) surrounding the drive shaft (2) and the sleeve (6), wherein the drive shaft, the sleeve (6) and the sheath (7) are pliable, wherein the drive shaft (2) at a proximal end of the drive shaft (2) comprises a coupling element (5) for connecting the drive shaft (2) to a drive motor (18), wherein the drive shaft (2) at least regionally consist of a alloy which contains at least 10% by weight of chromium, nickel and cobalt in each case. The invention moreover relates to a blood pump arrangement with such a catheter.Type: GrantFiled: October 31, 2014Date of Patent: November 19, 2019Assignee: ECP ENTWICKLUNGSGESELLSCHAFT MBHInventors: Mario Scheckel, Joerg Schumacher
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Patent number: 10478539Abstract: The catheter device comprises a motor at the proximal end of the catheter device and a drive shaft, extending from the proximal end section to the distal end section of the catheter device, for driving a rotating element located at the distal end of the catheter device. The catheter device also comprises a hose-like catheter body which encompasses the drive shaft and extends from the proximal end section to the distal end section. At the proximal end of the catheter device, the drive shaft is connected to a motor by a clutch. The clutch is a magnetic clutch with a proximal and a distal magnet unit. The proximal magnet unit is connected to the motor and the distal magnet unit to the drive shaft. The distal magnet unit is mounted fluid-tight in a clutch housing. The proximal end of the catheter body makes a fluid-tight connection with the clutch housing.Type: GrantFiled: January 20, 2016Date of Patent: November 19, 2019Assignee: AIS GMBH AACHEN INNOVATIVE SOLUTIONSInventors: Joachim Georg Pfeffer, Thomas Schmitz-Rode, Rolf W. Günther
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Patent number: 10478540Abstract: The present invention relates to a pump, in particular a blood pump having a proximal and a distal end and a pump housing arranged therebetween, a driveshaft arranged in an interior of the pump housing along the longitudinal direction, a conveying element arranged on the driveshaft, and a cannula. Here, the pump housing, the shaft arrangement and the conveying element are coordinated with one another in such a way that these guarantee the best possible efficiency and longevity of the pump.Type: GrantFiled: October 31, 2014Date of Patent: November 19, 2019Assignee: ECP ENTWICKLUNGSGESELLSCHAFT MBHInventors: Mario Scheckel, Robert Decke
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Patent number: 10478541Abstract: A centrifugal pump includes a rotating shaft, a pump substrate, a housing and an impeller. The pump substrate has a driving unit configured to rotate the rotating shaft. The housing has an inlet and an outlet and forms a pump chamber with the pump substrate. A body fluid sucked from the inlet flows through the pump chamber. The impeller is housed in the pump chamber and is configured to use the rotating shaft as an axis. The pump substrate has a magnetism generating source. The rotating shaft protrudes into the pump chamber from the pump substrate, and is pivotally supported on the pump substrate. A magnetic fluid is disposed on at least one of spaces formed among the pump substrate, the rotating shaft, and the impeller.Type: GrantFiled: September 24, 2015Date of Patent: November 19, 2019Assignee: HI-LEX CORPORATIONInventor: Makoto Teraura
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Patent number: 10478542Abstract: An intravascular heart pump assembly can include a rotor with at least one impeller blade, and a cannula. The present application describes various cannulas that can be manufactured from multiple layers of material to improve flexibility, manufacturability, and durability without increasing an outer diameter of the cannula. In one embodiment, the cannula includes an inflow section having a sheet formed of a shape memory material embedded within a polymer and having at least one lateral hole or aperture in the inflow section. The at least one lateral hole is defined by a first hole in the sheet and a second hole in the outer polymer layer of the cannula. The first hole and the second hole overlap so that blood can enter the cannula through the holes.Type: GrantFiled: March 20, 2017Date of Patent: November 19, 2019Assignee: ABIOMED, INC.Inventor: Emilia Jahangir
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Patent number: 10478543Abstract: A microfluidic device for increasing convective clearance of particles from a fluid is provided. A network of first channels can be separated from a network of second channels by a first membrane. The network of first channels can also be separated from a network of third channels by a second membrane. Fluid containing an analyte can be introduced in the network of first channels. Infusate can be introduced into the network of second channels, and waste-collecting fluid can be introduced into the network of third channels. A pressure gradient can be applied in a direction perpendicular to the direction of fluid flow in the network of first channels, such that the analyte is transported from the network of first channels into the network of third channels through the second membrane.Type: GrantFiled: January 11, 2013Date of Patent: November 19, 2019Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Christopher DiBiasio, Daniel I. Harjes, Joseph L. Charest, Jeffrey T. Borenstein
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Patent number: 10478544Abstract: A medicament preparation system, according to an embodiment, includes a water purification module and a medicament proportioning module. The system is configured to allow convenient and safe use in a home environment or a critical care environment as well as others affording safety, reliability, and a compact form factor.Type: GrantFiled: September 25, 2015Date of Patent: November 19, 2019Assignee: NXSTAGE MEDICAL, INC.Inventors: Goetz Friederichs, William Weigel, Dennis M. Treu, Jeffrey H. Burbank, James M. Brugger, Keith J. Wheeler, Scott W. Newell
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Patent number: 10478545Abstract: Parallel modules for in-line recharging of sorbent materials using alternate duty cycles for a sorbent cartridge. The sorbent cartridge can have two or more modules contained therein having connectors connecting each of the modules. One or more of the modules can be reusable and the sorbent materials therein can be recharged.Type: GrantFiled: January 12, 2018Date of Patent: November 19, 2019Assignee: Medtronic, Inc.Inventors: Bryant J. Pudil, Martin T. Gerber, David B. Lura, Thomas E. Meyer
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Patent number: 10478546Abstract: A hemodialysis vascular access device includes a proximal end sized and shaped to sealably couple to a hemodialysis catheter, a movable structure coupled to the proximal end, a fixation structure coupled to the movable region and sized and shaped for fixation on a patient, an elongated sleeve coupled to the fixation structure and sized and shaped for insertion into a patient's vasculature, and a valve at a distal end of the internal lumen. When a hemodialysis catheter is inserted into the device and coupled to the proximal end, distal movement of the proximal end relative to the fixation structure biases a distal end of the hemodialysis catheter from a position inside the elongated sleeve through a valve out of the device and into the patient's blood.Type: GrantFiled: September 6, 2016Date of Patent: November 19, 2019Assignee: Surmodics, Inc.Inventors: Joram Slager, Joe McGonigle, Anh Tri La, David E. Babcock, Bruce Jelle, Aleksey Kurdyumov, Timothy M. Kloke, Charlie Olson, Gary Maharaj, Nathan Lockwood
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Patent number: 10478547Abstract: An assembly structured for concurrent irrigation and aspiration of a nasal cavity including a housing having a supply container disposed therein for the removable retention of irrigating fluid. A nasal applicator comprises first and second passages respectfully structured to deliver irrigating fluid to the nasal cavity and concurrently remove waste fluid therefrom. An activating assembly includes a plunger biased into a continuous pressure applying, dispensing relation to the irrigating fluid and a valve assembly is selectively disposable into an open position facilitating fluid communication between the supply container and the applicator for the delivery of the irrigating fluid therethrough into the nasal cavity. The activating assembly is further structured to create a negative pressure within the chamber which communicates with the second passage of the applicator to facilitate delivery of the waste fluid therefrom along a path of travel to an interior of the chamber.Type: GrantFiled: September 6, 2016Date of Patent: November 19, 2019Assignee: PREVA, LLC.Inventors: Keith Rubin, Ken Solovay, James Layer, Alex Desimone
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Patent number: 10478548Abstract: Embodiments of the invention relate to poles with wheels with an onboard power unit that be longitudinally fixed in place and positioned about a medial position of the pole or may be configured to rise and lower in concert with wheels supporting the floor when on the floor and that can hold medical and/or accessory equipment, typically in a clinical or hospital environment.Type: GrantFiled: March 18, 2016Date of Patent: November 19, 2019Assignee: Skytron, LLCInventors: Samuel A. Blankenship, Peter B. Blankenship, Richard Baumhardt
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Patent number: 10478549Abstract: An intravenous line connection support device holds an intravenous connection port in a static position relative to a static structure or patient to facilitate connection to the port. The device includes a support flange coupled to and extending from a base. A connection post is coupled to and extends from the base. A slit extends into the connection post defining a pair of spaced arms. Opposite faces of the spaced arms include concavely arcuate portions defining a receiver within the slit configured for receiving a connection port of an intravenous line therein. A fastener has a head and a shaft. The shaft extends through the arms and across the slit. The shaft engages the arms such that movement of the shaft selectively urges the arms together and apart wherein the fastener is configured for securing the connection port within the receiver.Type: GrantFiled: August 25, 2017Date of Patent: November 19, 2019Inventor: Mike Lacey
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Patent number: 10478550Abstract: In a device for ambulatory wearing by the patient containing a pump for delivery of injection fluid or for removal of analysis fluid, the drive motor for the mechanically driven pump system is a Lavet-type stepper motor of small size designed for having a high mechanical power and low peak current requirement. Using this Lavet-type motor for syringe-type or peristaltic preferably patch-type pumps high infusion rates needed for e.g. bolus insulin injection or the delivery of therapeutic antibodies are achieved, and important safety features can be easily and reliably controlled, manufacturing costs get significantly reduced, and the overall size and weight of the device becomes smaller, for patient convenience.Type: GrantFiled: August 26, 2014Date of Patent: November 19, 2019Assignee: PHARMASENS AGInventors: Paul Hadvary, Rudolf Dinger, Hansjorg Tschirky
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Patent number: 10478551Abstract: A system and method can provide for a remote electronic device to be used to remotely initiate delivery of a medicament bolus with a medical device, such as an insulin pump, with the medical device providing audible or tactile confirmation of the programmed bolus. The bolus amount can be calculated by or programmed or otherwise entered into the smartphone, etc., and then transmitted to the medical device. When the pump receives the transmitted bolus amount, it issues one or more indications such as audible sounds and/or vibrations in any number of desired combinations. For instance, each individual sound or vibration may correspond to an increment of the medicament. The user can therefore determine the size of the medicament bolus by the number of sounds or vibrations and can confirm or cancel delivery of the bolus.Type: GrantFiled: July 19, 2017Date of Patent: November 19, 2019Assignee: Tandem Diabetes Care, Inc.Inventor: Michael Rosinko
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Patent number: 10478552Abstract: The subject invention provides a drug delivery device for injecting medicament which includes: a tubular reservoir; a stopper slidably disposed in the reservoir; a spring for moving the stopper in the reservoir; at least one needle, the needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, the lumen being in direct or indirect communication with the reservoir; a needle driver for displacing the needle; and, an actuator. Activation of the actuator causes the spring to move the stopper and the needle driver to displace the needle. The needle moves relative to, and separately from, the reservoir with the needle being displaced. Advantageously, with the subject invention, a drug delivery device is provided wherein a needle is moved, relative to the reservoir, in being displaced for injection. This permits control of the needle displacement separate from the reservoir.Type: GrantFiled: July 12, 2016Date of Patent: November 19, 2019Assignee: Becton, Dickinson and CompanyInventors: Richard A. Cronenberg, Lionel Vedrine, Paul Alchas
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Patent number: 10478553Abstract: An apparatus includes a body, a cannula, and a needle. The cannula is flexible and extends distally from the body. The needle is slidably disposed in the cannula. The needle includes a sharp distal tip and a curved portion. The needle is configured to translate relative to the cannula between a proximal position and a distal position. The distal tip is configured to be positioned inside the cannula when the needle is in the proximal position. The distal tip is configured to be positioned outside the cannula when the needle is in the distal position. The needle is resiliently biased to extend along a curve through the curved portion.Type: GrantFiled: February 22, 2017Date of Patent: November 19, 2019Assignee: ORBIT BIOMEDICAL LIMITEDInventors: Thomas E. Meyer, Benjamin L. Ko, Isaac J. Khan, Daniel W. Price, Brendan J. Oberkircher, Michael F. Keane
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Patent number: 10478554Abstract: A device for delivering fluid to a user includes a housing, a drive motor assembly in the housing, a force sensor, and an electronics module. The drive motor assembly regulates delivery of fluid by actuating a piston of a fluid reservoir, and the force sensor generates output levels in response to force imparted thereto during, for example, fluid delivery operations. The electronics module processes the output levels of the force sensor to assess the operating health of the force sensor, to check for occlusions in the fluid delivery path, and to monitor the seating status of the fluid reservoir.Type: GrantFiled: August 21, 2017Date of Patent: November 19, 2019Assignee: Medtronic MiniMed, Inc.Inventors: Afshin Bazargan, Pablo Vazquez, Hsiao-Yu S. Kow, Salman Monirabbasi, Ian B. Hanson
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Patent number: 10478555Abstract: A system and method for accessing and treating the cerebrospinal fluid with a multilumen catheter configured for placement along a cerebrospinal fluid pathway and a subcutaneous, dual reservoir/pump. The subcutaneous dual reservoir/pump allows simultaneous, bidirectional cerebrospinal fluid access and cerebrospinal fluid exchange. The two chambers prevent mixing of newly treated and discardable cerebrospinal fluid. The subcutaneous dual reservoir/pump can be used inline with other cerebrospinal fluid devices. The catheter may be coupled with a medical probe that sends a wire to a computational device, which can then send wireless data and receive wireless instructions. A method of assessing cerebrospinal fluid infections is provided, whereby monitoring of the cerebrospinal glucose concentrations with a cerebrospinal glucose sensor and analysis of the data by a computational device can notify a patient or medical provider of an impending infection.Type: GrantFiled: August 16, 2010Date of Patent: November 19, 2019Inventor: Milan Radojicic
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Patent number: 10478556Abstract: Methods and systems are disclosed for estimating a glucose level of a person having diabetes and selecting automatically open-loop and closed-loop control for a connected therapy delivery device. The method may comprise analyzing measured glucose results and corresponding impedance values received from a glucose sensor coupled to the person with a probability analysis tool implemented by a microcontroller to determine a total quality score that is based on the minimum constraint of a probability of glucose sensor accuracy determined measured glucose results and a probability of sensing quality determined from the impedance values. The microcontroller may estimate the glucose level of the person with a recursive filter based on the plurality of measured glucose results weighted with the total quality score and select automatically either open-loop control or closed-loop control for the connected therapy delivery device based on the value of the total quality score.Type: GrantFiled: March 4, 2016Date of Patent: November 19, 2019Assignee: Roche Diabetes Care, Inc.Inventors: Harvey B. Buck, Jr., David L. Duke
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Patent number: 10478557Abstract: Medical devices and related patient management systems and parameter modeling methods are provided. An exemplary method of operating a sensing device associated with a patient involves obtaining current operational context information associated with the sensing device, obtaining a parameter model associated with the patient, calculating a current parameter value based on the parameter model and the current operational context information, obtaining one or more signals from a sensing element configured to measure a condition in a body of the patient, and providing an output that is influenced by the calculated current parameter value and the one or more signals.Type: GrantFiled: August 18, 2016Date of Patent: November 19, 2019Assignee: Medtronic MiniMed, Inc.Inventors: Andrea Varsavsky, Yunfeng Lu, Keith Nogueira, Jeffrey Nishida
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Patent number: 10478558Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.Type: GrantFiled: December 12, 2016Date of Patent: November 19, 2019Assignee: BAYER HEALTHCARE LLCInventors: Martin J. Uram, Michael J. Yanniello, Barry L. Tucker, David A. Mishler, Edward J. Rhinehart, Mark Trocki, Arthur E. Uber, III, Kevin P. Cowan, John A. Brosovich
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Patent number: 10478559Abstract: A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. The housing includes a retractable guard and an interference component, e.g., a lock ring, adjacent to the retractable guard that interferes with the movement of the retractable guard. An energy source is configured for biasing the plunger to produce an injecting pressure to jet inject the medicament from the fluid chamber through the needle to an injection site.Type: GrantFiled: May 1, 2015Date of Patent: November 19, 2019Assignee: Antares Pharma, Inc.Inventors: James W. Lannan, Julius C. Sund
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Patent number: 10478560Abstract: A jet injector that includes a prefilled syringe. The syringe includes a fluid chamber that contains a medicament. The syringe also has an injection-assisting needle, and a plunger is movable within the fluid chamber. A housing is configured for allowing insertion of the needle to a penetration depth. An energy source is configured for biasing the plunger to produce an injecting pressure in the medicament in the fluid chamber of between about 80 and 1000 p.s.i. to jet inject the medicament from the fluid chamber through the needle to an injection site.Type: GrantFiled: April 21, 2017Date of Patent: November 19, 2019Assignee: Antares Pharma, Inc.Inventor: Paul R. Lesch
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Patent number: 10478561Abstract: A sensor for detecting a change in state of an asset comprising including a transmission antenna operable to transmit a control signal to an external device, control electronics connected to the transmission antenna configured to provide instructions to the transmission antenna to transmit the control signal, and a bypass antenna positioned and configured to prevent the control electronics from providing the instructions to the transmission antenna when the bypass antenna is in an undisturbed position and to permit the control electronics to provide the instructions to the transmission antenna when the bypass antenna is displaced from the undisturbed position.Type: GrantFiled: July 3, 2018Date of Patent: November 19, 2019Inventor: Minhong Yu
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Patent number: 10478562Abstract: A drive mechanism of a drug delivery device for setting and dispensing of a dose of a medicament includes a housing, a piston rod, a dose indicating member with a dose size information thereon, and a drive wheel. The piston rod engages with a piston of a cartridge for displacing the piston in a distal direction. The dose indicating member is connected to a spring element and is rotatable in a dose incrementing direction against the action of the spring element for setting a dose. The drive wheel is operably engaged with the piston rod for displacing the piston rod in the distal direction for dose dispensing. The dose indicating member is engageable with the drive wheel during dose dispensing to transfer a force to the drive wheel when driven by the relaxing spring element in a dose decrementing direction.Type: GrantFiled: April 8, 2014Date of Patent: November 19, 2019Assignee: SanofiInventors: Stefan Bayer, Daniel Berning, Philippe Blank, Wolfgang Pelzer, Björn Wilden
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Patent number: 10478563Abstract: A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners.Type: GrantFiled: February 6, 2017Date of Patent: November 19, 2019Assignee: W. L. Gore & Associates, Inc.Inventors: Edgar G. Ashmead, Edward C. Gunzel, Michael P. Moritz
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Patent number: 10478564Abstract: A handheld injection device includes a housing containing a cartridge, a dose setting means being operable in a first direction to set a desired dose to be dispensed, a piston rod being adapted to cooperate with a piston so as to cause a set dose to be injected from the cartridge, and a first clicker component, which is largely rotationally constrained to the housing, and a second clicker component, which is rotatable relative to the housing during dose dispensing. The clicker components are adapted to contact each other only at the end of dispensing of a set dose to thereby provide an audible and/or tactile first feedback to a user. The first clicker component is displaceable relative to the housing between a proximal dose setting position and a distal dose dispensing position.Type: GrantFiled: April 8, 2014Date of Patent: November 19, 2019Assignee: SanofiInventor: Anthony Paul Morris
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Patent number: 10478565Abstract: An assembly (100) for a drug delivery device is presented. The assembly comprising a housing, a clicker member (2) and a clutch member (1) comprising a rotatable clutch feature (20). The assembly further comprises a counter clicker (8) which is configured to interact with the clicker member (2) to form a clicker mechanism, and a spring element (3) arranged between the clicker member (2) and the clutch member (1), the spring element (3) being arranged to move the clutch member (1) towards the first position and away from the clicker member (2) away from each other.Type: GrantFiled: November 10, 2014Date of Patent: November 19, 2019Assignee: Sanofi-Aventis Deutschland GMBHInventor: Torsten Kraft
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Patent number: 10478566Abstract: A Huber safety needle assembly including a body, configured to receive a needle. The body further including an upper portion having a first gripping portion coupled thereto, a lower portion having a second gripping portion coupled to thereto, and a hinge mechanism. The needle having a needle tip configured to be received in the body. The hinge mechanism is configured to operably transition the body between a closed configuration and an open configuration. The closed configuration allowing at least a portion of the needle, including the needle tip, to extend below the bottom surface of the lower portion of the body. The open configuration allowing the needle tip to be securely received within the lower portion such that it does not extend below the bottom surface of the lower portion.Type: GrantFiled: August 31, 2015Date of Patent: November 19, 2019Assignee: Medical Components, Inc.Inventors: Matthew Gunn, Kurt Shimer, Timothy M. Schweikert, Mark S. Fisher, Kevin Sanford
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Patent number: 10478567Abstract: A syringe assembly includes a housing having a cavity for receiving an associated fluid. A plunger assembly includes a piston and a shaft connected thereto for selectively dispensing the associated fluid from the housing through a dispensing opening. A container receives the housing and plunger assembly. The container has a first opening at a first end that selectively receives a cap thereon and covers the dispensing opening when the cap is secured to the container, and second opening at a second end that opens to the plunger assembly shaft.Type: GrantFiled: November 11, 2015Date of Patent: November 19, 2019Inventor: Kenneth Anthony Loritz
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Patent number: 10478568Abstract: A needle safety device has an outer tube within which a syringe barrel is slideably receivable. A collar in the outer tube is moveable relative thereto and rotatably attachable to the distal end of the barrel. A force member biases the outer tube in a distal direction. A track is formed in the inner surface of the outer tube. A pin extending radially outwardly from the collar slidingly engages the track. In a staging position, the barrel is inspectable. In a pre-injection position, the cannula extends a first length beyond the outer tube. In a full-insertion position, the cannula extends a second length greater than the first length beyond the outer tube. In a locked position, the cannula is entirely within the outer tube.Type: GrantFiled: February 20, 2018Date of Patent: November 19, 2019Assignee: WEST PHARMACEUTICAL SERVICES, INC.Inventors: Christopher Evans, Brian Costello, Christopher Gieda
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Patent number: 10478569Abstract: The present invention generally provides a device for inserting needles and alleviating the discomfort associated with needle insertion. In certain embodiments, the device is suited for injecting butterfly needles and particularly butterfly needles that are attached to infusion tubing. The patient or caregiver loads a butterfly needle with tubing attached into the base of the drive plunger. The needle with tubing attached is retracted into the housing of the device by retracting the inner plunger. Once retracted, the device is activated and ready to administer a needle into the tissue of a patient. The device is then placed on the location of the skin where injection is desired. The surface that contacts the skin may be textured and may include a contact switch that causes the device to vibrate when slight pressure is applied through contact with the skin.Type: GrantFiled: April 4, 2014Date of Patent: November 19, 2019Inventors: Andrew Sealfon, Christopher Erol Ogut
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Patent number: 10478570Abstract: A medication delivery apparatus and system for the application of a local anesthetic to a treatment site, such as an airway, and method for use of same are disclosed. In one embodiment of the medication delivery apparatus and system, a reservoir supplies a local anesthetic to a lower chamber of a housing wherein an ultrasonic transducer applies ultrasonic energy thereto, thereby nebulizing the local anesthetic. A control valve is interposed between a source of positive pressure air and an upper chamber of the housing to selectively apply positive air pressure to the upper chamber. Upon the application of positive air pressure, the airflow delivers the nebulized anesthetic to a patient's airway by way of a laryngoscope side port coupling, laryngoscope vacuum port coupling, or catheter coupling, for example. The application of local anesthetic, itself, in this nebulized manner mitigates gaging, chocking, aspirating, bucking and laryngospasms.Type: GrantFiled: July 14, 2014Date of Patent: November 19, 2019Assignee: Dualams, Inc.Inventor: John S. Houston