Patents Issued in November 28, 2019
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Publication number: 20190359515Abstract: Disclosed is a method of forming a hole in a glass substrate by using a pulsed laser, the method including (1) preparing the glass substrate including a first surface and a second surface that face each other; (2) forming a concave portion on the first surface by irradiating, with a first condition, the pulsed laser onto the first surface of the glass substrate through a lens; and (3) forming the hole by irradiating the pulsed laser onto the concave portion with a second condition such that energy density of the pulsed laser is less than or equal to a processing threshold value of the glass substrate.Type: ApplicationFiled: August 6, 2019Publication date: November 28, 2019Applicant: AGC Inc.Inventors: Kohei HORIUCHI, Motoshi ONO
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Publication number: 20190359516Abstract: The invention relates to a device, system, and method for forming a core-rod for optical fibers by collapsing a tube comprising deposited layers of silica to form the core-rod. The device comprises an elongate cavity, an elongate cylindrical carbon liner bounding the cavity, the liner connecting to a frame of the device at opposing end portions, a heating element in a heating element space, surrounding the liner, the liner separating the heating element space from the cavity, a ring of a refractory material, fixated to the frame, surrounding a part of a length of the cavity, the liner being provided such that an inner surface portion at a first end portion of the liner mates with a cylindrical outer surface portion of the ring such that the liner can axially move with the first end portion thereof along the outer surface portion of the ring.Type: ApplicationFiled: May 22, 2019Publication date: November 28, 2019Inventors: Igor Milicevic, Gertjan Krabshuis, Mattheus Jacobus Nicolaas Van Stralen, Raoul Hens
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Publication number: 20190359517Abstract: A method of processing an optical fiber includes drawing the optical fiber from a heated glass source, reheating the optical fiber, and cooling the optical fiber under vacuum at a cooling rate less than the cooling rate of the optical fiber in air at 25° C. and 1 atm. Cooling the optical fiber under vacuum is conducted after reheating the optical fiber. Cooling the optical fiber under vacuum reduces the rate of heat transfer from the optical fiber, which may enable further relaxation of the glass and reduction in the fictive temperature of the optical fiber. A system for processing an optical fiber includes a furnace containing a fiber preform, a first positioner, a reheating device, and a treatment device downstream of the reheating device, the treatment device operable to cool the optical fiber under vacuum to reduce the rate of heat transfer from the optical fiber.Type: ApplicationFiled: May 21, 2019Publication date: November 28, 2019Inventors: Yacob Mesfin Argaw, Nikolaos Pantelis Kladias, Robert Clark Moore, Bruce Warren Reding, Chunfeng Zhou
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Publication number: 20190359518Abstract: The invention relates to a glass sheet having a luminous transmission LTD4?87% and having a composition free of antimony and arsenic, comprising total iron (expressed in the form of Fe2O3) from 0.002-0.04% and erbium (expressed in the form of Er2O3) from 0.003-0.1%. The glass sheet composition further having a redox ratio ?32% and satisfying the formula 1.3*Fe2O3?Er2O3?21.87*Cr2O3?53.12*Co?2.6*Fe2O3. Such a glass sheet has a high luminous transmittance and has warm-toned to neutral colored edges and is particularly suitable due to its aesthetics as building glass or interior glass, as well as in furniture applications, as automotive glass, or as cover glass in electronic devices/displays.Type: ApplicationFiled: July 18, 2017Publication date: November 28, 2019Applicant: AGC GLASS EUROPEInventors: Thomas LAMBRICHT, Audrey DOGIMONT
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Publication number: 20190359519Abstract: A method of forming a dissolvable part of amorphous borate includes: preparing a mixture comprising one or more boron compounds and one or more alkali compounds, at least one of the one or more boron compounds and the one or more alkali compounds being hydrous; heating the mixture to a melting temperature for a predetermined time to melt the mixture and release water from the mixture to form an anhydrous boron compound that is moldable, wherein the amount of alkali compound being selected to achieve an alkali oxide content of between about 10 to 25%; with the anhydrous boron compound at a molding temperature, molding the anhydrous boron compound in a mold; and cooling the anhydrous boron compound to form a solid.Type: ApplicationFiled: August 7, 2019Publication date: November 28, 2019Applicant: Genics Inc.Inventors: Wesley James Wall, Adam Wall, Ray Whitaker
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Publication number: 20190359520Abstract: An optical fiber manufacturing method includes: drawing an optical fiber preform to form a bare optical fiber; cooling the bare optical fiber; coating an uncured coating layer that includes a resin precursor on an outer periphery of the bare optical fiber; curing the uncured coating layer to form a semi-cured coating layer; further curing the semi-cured coating layer; and cooling the semi-cured coating layer by at least one non-contact direction changer between the curing of the uncured coating layer and the curing of the semi-cured coating layer.Type: ApplicationFiled: February 8, 2018Publication date: November 28, 2019Applicant: FUJIKURA LTD.Inventor: Itaru Ishida
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Publication number: 20190359521Abstract: A process for manufacturing an insulating product based on mineral fibers bonded by an organic binder includes applying an aqueous binding composition to mineral fibers: evaporating a solvent phase of the aqueous binding composition: and thermal curing of the nonvolatile residue of the composition. The aqueous binding composition includes at least one hydrogenated. sugar, at least one polyfunctional crosslinking agent, and hypophosphorous acid. The binding composition is free of reducing sugars or contains at most 10% by weight of reducing sugars.Type: ApplicationFiled: January 22, 2018Publication date: November 28, 2019Applicant: SAINT-GOBAIN ISOVERInventors: Pierre SALOMON, Marion CHENAL
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Publication number: 20190359522Abstract: Disclosed herein are seals for liquid-tight bonding of an optical window comprising a Bi—In alloy. Also disclosed are optical cells comprising the Bi—In alloy seals to provide a liquid-tight seal between a cell housing and a drilled optical window.Type: ApplicationFiled: August 12, 2019Publication date: November 28, 2019Applicant: PIKE Technologies of Wisconsin, Inc.Inventors: Alec Cameron Fisher, Kent Gundlach
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Publication number: 20190359523Abstract: High alumina cement is produced in a submerged combustion melter, cooled and ground.Type: ApplicationFiled: August 5, 2019Publication date: November 28, 2019Inventors: Gerard DEMOTT, Bostjan MAROLT, David DUCARME
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Publication number: 20190359524Abstract: A mineral composition is shown which contains a mixed solid phase of synthetic calcium and magnesium carbonates, formed of a crystallized calcic portion and a plate-like crystallized magnesian portion. The crystals of the calcic portion and those of the magnesian portion are aggregated in the form of composite aggregates. These aggregates themselves are at least partly agglomerated in the form of agglomerates. The calcic portion has at least one carbonate such as calcite or the mixtures of calcite and aragonite. The magnesian portion contains hydromagnesite in plate-like form. The aggregates are further formed of a calcic core on which hydromagnesite plates are aggregated.Type: ApplicationFiled: May 29, 2019Publication date: November 28, 2019Applicant: S. A. Lhoist Recherche et DeveloppementInventors: Marion Lorgouilloux, Marc Pelletier, Robert Sebastian Gartner, Thierry Chopin
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Publication number: 20190359525Abstract: The invention provides a method for obtaining a structural element having pond ash. The method includes selecting a pond ash and adding cement to the pond ash to obtain a first mixture. Foam is sprayed to the first mixture and the said mixture is then mixed with water to form a foam concrete. The foam concrete thus obtained is then poured into a mould to obtain the desired structural element.Type: ApplicationFiled: July 31, 2017Publication date: November 28, 2019Inventor: Sridhar NADAVI
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Publication number: 20190359526Abstract: A composition including at least: a binder base chosen from: a bitumen base, a pitch base, a clear binder, or a mixture of one or more of these binder bases, an acid compound of general formula (I): R—(COOH)z (I). an amide compound of general formula (II): R?—(NH)nCONH—(X)m—(NHCO)p(NH)n—R? (II) the compounds (I) and (II) being present in a weight ratio ranging from 10:1 to 1:16, for preparing a mastic asphalt composition. Mastic asphalt compositions and surfacings are thus obtained.Type: ApplicationFiled: December 20, 2017Publication date: November 28, 2019Applicant: TOTAL MARKETING SERVICESInventors: Yvong HUNG, Régis VINCENT
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Publication number: 20190359527Abstract: The invention comprises a method comprising heating a solid, naturally occurring mineral so that at least a portion of the solid naturally occurring mineral melts to form an at least partially molten naturally occurring mineral and quenching the at least partially molten naturally occurring mineral in water so that at least a portion of the quenched naturally occurring mineral is in amorphous form.Type: ApplicationFiled: May 22, 2019Publication date: November 28, 2019Inventor: Romeo Ilarian Ciuperca
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Publication number: 20190359528Abstract: The present inventive subject matter is directed to repair compositions for thermal barrier coatings and methods of use thereof. The repair compositions include a ceramic composition, a colloidal solution, an aqueous binder, an aqueous dispersant, and an aqueous ammonia solution. The ceramic composition includes a first population of yttria-stabilized zirconia particles having a mean diameter from about 250 nm to about 1000 nm, a second population of yttria-stabilized zirconia particles having a mean diameter from about 2 ?m to about 10 ?m, and a third population of yttria-stabilized zirconia particles having a mean diameter from about 20 ?m to about 250 ?m. One method includes depositing the repair layer onto the damaged region, the repair layer including the repair composition, and heat treating the repair layer.Type: ApplicationFiled: August 5, 2019Publication date: November 28, 2019Inventors: Kevin Paul McEvoy, James Ruud, Lawrence E. Szala, Susan Corah, Atanu Saha, Hrishikesh Keshavan
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Publication number: 20190359529Abstract: A crucible includes an outer element and an inner element. The outer element includes a first portion that is horizontal at a bottom end of the crucible and a second portion that ascends radially outwardly from the bottom end of the crucible to a top end of the crucible at a first acute angle to a vertical axis. The inner element includes a conus with a cylinder at a base of the conus. The conus descends radially outwardly from the top end of the crucible to the bottom end of the crucible at a second acute angle to the vertical axis. The inner element includes a base portion of the cylinder attached to the first portion of the outer element using a sealant to form a hollow mold between an inner portion of the outer element and an outer portion of the inner element.Type: ApplicationFiled: May 24, 2018Publication date: November 28, 2019Inventors: Rong WANG, Haresh Siriwardane, Igor Peidous, Vijay Nithianathan
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Publication number: 20190359530Abstract: The present invention provides a method for manufacturing a ceramic electrostatic chuck which enables high purity and minimum thickness variation of a dielectric layer formed of ceramics or composite ceramics. The method includes: forming grooves for electrode pattern formation in a dielectric layer formed of ceramics or composite ceramics and having a density of 95% or greater; forming an electrode pattern by filling the grooves with a metal; forming an activated bonding layer configured for joining on the dielectric layer; and joining an insulator layer, which is formed of ceramics or composite ceramics and has a density of 95% or greater, with the dielectric layer.Type: ApplicationFiled: September 13, 2018Publication date: November 28, 2019Applicant: Blue Ocean Research & Network LimitedInventor: Manabu Matsubara
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Publication number: 20190359531Abstract: A method of making a fiber preform for ceramic matrix composite (CMC) fabrication that utilizes a fugitive binder and a machining step is described. The method includes, according to one embodiment, laying up a plurality of plies to form a stack, where each ply comprises an arrangement of fibers. The stack is infiltrated with a polymer at an elevated temperature to form an infiltrated stack that is cooled to form a rigid preform. The rigid fiber preform is machined to have a predetermined shape, such that a machined fiber preform is formed. A composite assembly including the machined fiber preform is formed and then the composite assembly is heated at a sufficient temperature to pyrolyze the polymer. Thus, a porous preform of a predetermined geometry is formed for further processing into a CMC.Type: ApplicationFiled: May 23, 2018Publication date: November 28, 2019Inventors: Wayne Steffier, Michael Jacquinto, Stephen Harris, Robert Shinavski, Todd Engel
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Publication number: 20190359532Abstract: By surface roughening of CMC component via a pico-laser treatment a good adhering of a plasma sprayed coating is achieved.Type: ApplicationFiled: November 7, 2017Publication date: November 28, 2019Inventors: Niels Van der Laag, Arturo Flores Renteria, David J. Mitchell
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Publication number: 20190359533Abstract: A coated concrete body, more particularly an element for a tower, more particularly for a tower for a wind turbine, and also of a method for its production.Type: ApplicationFiled: August 12, 2016Publication date: November 28, 2019Inventors: Norbert HÖLSCHER, Edelfried VOIGT, Frank HOFFMANN
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Publication number: 20190359534Abstract: The invention relates to the field of controlled release fertilizer technology, and in particular to a special film-coated controlled release fertilizer for peanut in saline-alkali soil, which comprises an outer layer, an intermediate layer and an inner layer, integrates the ingredients for salt resistance improvement, etiolated seedling prevention, disease and pest control, growth promotion and pod plumpness promotion, controls the release period, improves the fertilization efficiency without the need of top application throughout the growth period, and saves labor cost.Type: ApplicationFiled: July 20, 2018Publication date: November 28, 2019Applicant: Biotechnology Research Center, Shandong Academy of Agricultural SciencesInventors: Jialei ZHANG, Shubo WAN, Feng GUO, Xinguo LI, Yun GENG, Sha YANG, Zheng ZHANG, Haijun ZHAO, Jingjing MENG
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Publication number: 20190359535Abstract: According to some embodiments there is provided a process for the recovery of SOP from Sulphate bearing mineral and Carnallite or Sylvenite, comprising: Dissolving Carnallite in water to obtain Sylvenite and high Magnesium Chloride brine; Adding Sodium Sulphate to said Carnallite to produce mixture of Kainte\Leonite, KCl and NaCl precipitant and brine containing Mg Cl2, KCl, NaCl; Separating the NaCl from the mixture; Obtaining a precipitant mixture of Leonite with KCl; Filtering said Leonite and washing with water to yield pure mixture of Leonite with KCl; Adding KCl to the Leonite with the KCl; and Decompose said Leonite with the KCl to SOP.Type: ApplicationFiled: December 15, 2017Publication date: November 28, 2019Inventors: Joseph LATI, Khalil ABU RABEAH, Ofir COHEN, Einat VIZENBERG, Natalia GEINIK
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Publication number: 20190359536Abstract: Processes for manufacturing organic fertilizer products, such as liquid and solid organic fertilizer, from animal manure are disclosed, together with the fertilizer products produced therefrom.Type: ApplicationFiled: June 11, 2019Publication date: November 28, 2019Applicant: EnviroKure, IncorporatedInventors: Sushil K. BHALLA, Gregory J. Dicosola, Devon K. Hooper, Sarabjit S. Randhava, Michael A. Laughlin
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Publication number: 20190359537Abstract: This disclosure relates to a semi-humic material, and compositions comprising the same, obtained from leonardite ore and a non-humic organic carbon source and a process for obtaining the same. Also described are methods for maintaining more available nitrogen and phosphorus in the plant root zone and minimizing premature leaching and loss of the nitrogen and/or phosphorus into the atmosphere, surface waters and/or subsurface ground water.Type: ApplicationFiled: May 2, 2019Publication date: November 28, 2019Inventors: Taha Rezai, John Breen, Thomas J. Gerecke, Qingwen He, Margaret Mae Abercrombie, Susan Her, Ryan Dierking, Gregory A. Crawford, Montell L. Bayer
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Publication number: 20190359538Abstract: A mixture comprising 20% to 35% by weight of water and 15% to 19% by weight of 3,4-dimethylpyrazole, based on the overall mixture that adds up to 100% by weight, and phosphoric acid in a molar ratio to 3,4-dimethylpyrazole of at least 1:1 is used for coating of nitrogen-containing fertilizers.Type: ApplicationFiled: January 30, 2018Publication date: November 28, 2019Inventor: Nils PETERS
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Publication number: 20190359539Abstract: An inhibitor composition contains alkyl thiophosphoric triamide (or a mixture of alkyl thiophosphoric triamide and dicyandiamide), dissolved in a liquid medium comprising at least one organic solvent and at least one amine stabilizer, is useful in making fertilizer compositions and in a method of fertilizing target plants.Type: ApplicationFiled: August 7, 2019Publication date: November 28, 2019Applicant: RHODIA OPERATIONSInventors: Marivi ORTIZ-SUAREZ, James SAWYER, Christopher HARRIS
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Publication number: 20190359540Abstract: Present invention relates to sp2 carbon nanogranules with iron incorporated in it from heavy petroleum residue of a refinery and thereby utilizing the materials for improved synthesis of light olefins (C2-C4) from syngas in a single step Fischer Tropsch synthesis to lower olefins, (FTO). The efficient iron incorporated carbon nanogranules derived from low value heavy petroleum residue are very attractive as catalytic system for direct synthesis of light olefin (C2-C4) from syngas at CO conversion up to 30%.Type: ApplicationFiled: June 14, 2019Publication date: November 28, 2019Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Indrajit Kumar GHOSH, Kumar UMESH, Ankur BORDOLOI
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Publication number: 20190359541Abstract: An integrated process for forming a combined feedstock stream comprising catalytically cracking a first hydrocarbon feedstock to form a full range cracked full naphtha stream and a first light olefins stream, steam cracking a second hydrocarbon feedstock to form a pyrolysis gasoline stream and a second light olefins stream mixing at least a portion of each of the full range cracked naphtha stream and the pyrolysis gasoline stream to form a combined stream, hydro-processing the combined stream to form a hydro-processed combined stream splitting the hydro-processed combined stream into a C5/C6 stream, and a first aromatic rich stream, splitting the first aromatic rich stream into a second aromatic rich stream and a heavy oil stream.Type: ApplicationFiled: May 12, 2017Publication date: November 28, 2019Inventors: Sheetal BAFNA, Sanjeev DESHPANDE, Michael HUCKMAN, Scott STEVENSON
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Publication number: 20190359542Abstract: A process for producing xylene from C9+ aromatic hydrocarbons comprises contacting a first feedstock comprising C9+ aromatic hydrocarbons with a first catalyst in the presence of 0 wt. % or more of hydrogen under effective vapor phase dealkylation conditions to dealkylate part of the C9+ aromatic hydrocarbons and produce a first product comprising benzene, toluene and residual C9+ aromatic hydrocarbons. A second feedstock comprising C9+ aromatic hydrocarbons and benzene and/or toluene is contacted with a second catalyst under effective liquid phase C9+ transalkylation conditions to transalkylate at least part of the C9+ aromatic hydrocarbons and produce a second product comprising xylenes.Type: ApplicationFiled: February 10, 2017Publication date: November 28, 2019Inventors: Todd E. Detjen, Jeevan S. Abichandani
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Publication number: 20190359543Abstract: The present invention relates to a hydrocarbon conversion process comprising contacting a hydrocarbon feed stream with a hydrocarbon conversion catalyst, wherein the hydrocarbon conversion catalyst comprises a first composition comprising a dehydrogenation drogenation active metal on a solid support; and a second composition comprising a transition metal and a doping agent on an inorganic support, wherein the doping agent is selected from zinc, gallium, indium, lanthanum, and mixtures thereof.Type: ApplicationFiled: November 16, 2017Publication date: November 28, 2019Applicant: SMH Co., LtdInventors: Amnart JANTHARASUK, Kongkiat SURIYE
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Publication number: 20190359544Abstract: The invention relates to a process for producing an olefin in which a reaction input stream containing at least one paraffin, oxygen and water is formed and in which a portion of the paraffin and of the oxygen in the reaction input stream is converted into the olefin by oxidative dehydrogenation using a catalyst to obtain a process gas, wherein the process gas contains at least the unconverted portion of the paraffin and of the oxygen, the olefin and the water from the reaction input stream. It is provided that at least one parameter which indicates an activity of the catalyst is determined and that an amount of the water in the reaction input stream is adjusted on the basis of the at least one determined parameter. A corresponding plant (100) likewise forms part of the subject matter of the invention.Type: ApplicationFiled: December 22, 2017Publication date: November 28, 2019Inventors: Mathieu ZELLHUBER, Martin SCHUBERT, Florian WINKLER, Andreas MEISWINKEL
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Publication number: 20190359545Abstract: A process for producing an olefin having N carbon atoms is proposed in which using a dehydrogenation a process gas is formed which contains at least the olefin having N carbon atoms, a paraffin having N carbon atoms and a hydrocarbon having N?1 carbon atoms and in which using at least a portion of the process gas a separation input is formed which is subjected to a low temperature separation in which the separation input is cooled stepwise over a plurality of temperature levels and condensates are separated from the separation input, wherein the condensates are at least partly subjected to a first low temperature rectification to obtain a first gas fraction and a first liquid fraction, wherein the first gas fraction contains at least the olefin having N carbon atoms in a lower proportion than in the condensates and the hydrocarbon having N?1 in a higher proportion than in the condensates.Type: ApplicationFiled: December 22, 2017Publication date: November 28, 2019Inventors: Andreas PESCHEL, Andreas OBERMEIER, Helmut FRITZ, Mathieu ZELLHUBER
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Publication number: 20190359546Abstract: A process for producing ethylene comprising: (a) reacting a reactant mixture in a reactor to yield a product mixture, wherein the reactor comprises a catalyst, wherein the reactant mixture comprises ethane, oxygen, and a chlorine intermediate precursor, wherein the product mixture comprises ethylene, unreacted ethane, carbon monoxide, and carbon dioxide, wherein the catalyst comprises a redox agent, an alkali metal, and a rare earth element; and (b) recovering at least a portion of the ethylene from the product mixture. The reacting in step (a) further comprises (i) contacting at least a portion of the chlorine intermediate precursor with the catalyst to form a chlorinated catalyst; (ii) allowing at least a portion of the chlorinated catalyst to generate a chlorine intermediate; and (iii) allowing at least a portion of the reactant mixture to react via the chlorine intermediate.Type: ApplicationFiled: August 5, 2019Publication date: November 28, 2019Inventor: Aghaddin MAMEDOV
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Publication number: 20190359547Abstract: A compound of Formula I, wherein R1, R2, R3, R4, R5 and R6 are independently hydrogen, halogen, an unsubstituted alkyl, alkenyl, alkynyl, cydoalkyi, cydoalkylalkyi, aryl, phenyl, or naphthyl group, and a substituted alkyl, alkenyl, alkynyl, cydoalkyi, cydoalkylalkyi, aryl, phenyl, or naphthyl group having as a substituent a halogen, alkoxy, substituted phenoxy, unsubstituted phenoxy group or a heteroatom such as oxygen, sulfur, nitrogen, phosphorus and boron.Type: ApplicationFiled: September 15, 2017Publication date: November 28, 2019Applicant: CURTIN UNIVERSITY OF TECHNOLOGYInventors: Zora SINGH, Alan David PAYNE, Shamim Ahmed Kamal Uddin KHAN, Muftah Miload MUSA
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Publication number: 20190359548Abstract: Provided is a method for preparing a diol. In the method, a saccharide and hydrogen as raw materials are contacted with a catalyst in water to prepare the diol. The employed catalyst is a composite catalyst comprised of a main catalyst and a cocatalyst, wherein the main catalyst is a water-insoluble acid-resistant alloy; and the cocatalyst is a soluble tungstate and/or soluble tungsten compound. The method uses an acid-resistant, inexpensive and stable alloy needless of a support as a main catalyst, and can guarantee a high yield of the diol in the case where the production cost is relatively low.Type: ApplicationFiled: August 7, 2019Publication date: November 28, 2019Inventors: Jing Liu, Hongbin Qi, Haiyu Ren, Indra Prakash, Yu Shi
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Publication number: 20190359549Abstract: The invention provides a process for recovering oxalic acid used in ferrous metal pickling procedures, thereby reducing the total cost and environmental load of the pickling treatments.Type: ApplicationFiled: September 11, 2017Publication date: November 28, 2019Inventors: Reuben David SCHAPIRO, Vladimir BOIKO, Lev SHAPIRO
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Publication number: 20190359550Abstract: Non-water soluble cannabinoid acids are isolated from trichomes and flower of Cannabis genus by leaching with alkaline water. The leaching with alkaline water converts the cannabinoid acids to water soluble salts. The resulting solution of cannabinoid salts may be used as a source of acidic cannabinoids for pharmaceutical applications or the cannabinoid acid salts may be converted back to their acid form and precipitated into a high purity microcrystalline powder by acidification of the aqueous solution. Compounds that are not water soluble and do not form salts in alkaline water such as many pesticides, fungicides and off flavors will not be concentrated.Type: ApplicationFiled: November 28, 2018Publication date: November 28, 2019Inventors: Robert Henry Wohleb, Thomas Jennings Wohleb, Joseph David Friis
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Publication number: 20190359551Abstract: Aspects of the present disclosure include fatty acid ?-hydroxyester compounds (e.g., fatty acid esters of ?-hydroxybutyrate), fatty acid esters of butanediol, and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions having one or more fatty acid ?-hydroxyester compounds and/or one or more fatty acid esters of butanediol. Methods for treating a subject by administering one or more esters to the subject are also provided. Kits containing one or more of the subject esters are also described.Type: ApplicationFiled: July 31, 2019Publication date: November 28, 2019Inventors: Eric Verdin, Scott Michael Ulrich, John C. Newman
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Publication number: 20190359552Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.Type: ApplicationFiled: August 7, 2019Publication date: November 28, 2019Applicants: Institut Pasteur de Montevideo, Universidad de la RepúblicaInventors: Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
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Publication number: 20190359553Abstract: The present invention provides a process for the preparation of N-phenoxyisopropyl ethanolamine of Formula (II) and its conversion to Phenoxybenzamine of Formula (I) or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: January 10, 2018Publication date: November 28, 2019Applicant: Aurobindo Pharma LtdInventors: Shashi Kant Tiwari, Rajesh Chennuri, Bhanuchandar Samala, Venkata Ramana Kintali, Sivakumaran Meenakshisunderam
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Publication number: 20190359554Abstract: The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a ?-amino-?-biphenyl-?-methylalkanoic acid, or acid ester, backbone.Type: ApplicationFiled: December 20, 2017Publication date: November 28, 2019Inventors: Florian Karl KLEINBECK-RINIKER, Tobias KAPFERER, Hongyong KIM, Jie KU, Kurt LAUMEN, Yunzhong LI, Wei PENG, Thomas RUCH, Thierry SCHLAMA, Yao YANG
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Publication number: 20190359555Abstract: Provided herein are processes, compounds and compositions for making (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid. Also provided herein a pharmaceutical compositions containing (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid.Type: ApplicationFiled: May 28, 2019Publication date: November 28, 2019Inventors: Richard B. Silverman, Matthew MOSCHITTO
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Publication number: 20190359556Abstract: Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1a, R1b, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6, R7, R8, R9, L1, L2, G1, G2, G3, a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.Type: ApplicationFiled: February 1, 2019Publication date: November 28, 2019Inventors: Xinyao Du, Steven M. Ansell
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Publication number: 20190359557Abstract: The invention relates to picolinamides of Formula I and their use as fungicides.Type: ApplicationFiled: November 28, 2018Publication date: November 28, 2019Inventors: Chenglin YAO, Kevin G. MEYER, Yu LU, Brian A. LOY, David M. JONES, Ronald J. HEEMSTRA, Jeffrey B. EPP, Johnathan E. DELORBE, Kyle A. DEKORVER, John F. DAEUBLE, SR.
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Publication number: 20190359558Abstract: Integrated process for the production of urea and urea-ammonium nitrate, comprising: reacting ammonia and carbon dioxide to form a reaction mixture (4) containing urea and unconverted materials, and also comprising the recovery of unconverted materials in a first recovery stage at a first pressure and in a second recovery stage at a second pressure, wherein ammonia-containing offgas (19) released by said second recovery stage are condensed at said second pressure, and said condensed offgas (20) are recycled to said first recovery stage.Type: ApplicationFiled: September 4, 2017Publication date: November 28, 2019Applicant: Casale SAInventor: Luca Rugnone
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Publication number: 20190359559Abstract: Disclosed is a novel method of controlling the formation of biuret in urea production. This is accomplished by reducing or preventing the formation of biuret in a concentration section, particularly in one or more concentrators or evaporators. The method comprises controlling the residence time of a urea aqueous stream treated in such concentration section in a manner independently of the volume flow per time interval of said stream into said concentration section. The residence time can be controlled, e.g., by providing the concentration section with an adjustable volume or by adding a gas to the urea stream to be treated. A combination of such measures can also be applied.Type: ApplicationFiled: August 9, 2019Publication date: November 28, 2019Applicant: Stamicarbon B.V.Inventor: Eelco MOSTERT
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Publication number: 20190359560Abstract: An anti-inflammatory drug containing a G0/G1 switch 2 (G0S2) inhibitor as an active ingredient is useful as a novel anti-inflammatory drug.Type: ApplicationFiled: March 19, 2019Publication date: November 28, 2019Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Shigehiro OHDO, Naoya MATSUNAGA, Akio OJIDA, Naoya SHINDO
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BASE GENERATOR, BASE-REACTIVE COMPOSITION CONTAINING SAID BASE GENERATOR, AND BASE GENERATION METHOD
Publication number: 20190359561Abstract: It is a subject of the present invention to provide a base generator which has high solubility to general-purpose organic solvents, can dissolve directly into a base-reactive compound, such as an epoxy-based compound, further is provided with both performance of high heat resistance and low nucleophilicity, and generates a strong base, a base-reactive composition comprising the base generator and a base-reactive compound, as well as a method for generating a base, etc. The present invention relates to a compound represented by the general formula (A), a base generator comprising the compound, a base-reactive composition which comprises the base generator and a base-reactive compound, as well as a method for generating a base, etc.Type: ApplicationFiled: August 9, 2019Publication date: November 28, 2019Inventors: Nobuhiko SAKAI, Kosuke YANABA, Koji ARIMITSU -
Publication number: 20190359562Abstract: Biodegradable surfactants are described, in which an amphiphilic heteroatom containing hydrocarbon optionally comprising at least one counterion (Z), and related compositions, methods and systems. Biodegradable surfactant described herein has an aHLB value in accordance with equation (1): aHLB=20*Gh/(Gh?Gt) (1) wherein Gh is the Group Number of a hydrophilic head portion of the biodegradable surfactant optionally comprising the at least one counterion (Z), and Gt is the Group Number of a hydrophobic tail portion of the biodegradable surfactant. A biodegradable surfactant in the sense of the disclosure can be tuned to a set hydrophilic-lipophilic balance (aHLB) by selectively modifying at least one tuning moiety of the biodegradable surfactants to provide tuned biodegradable surfactants having an increase or decrease in their adjusted hydrophilic-lipophilic balance (aHLB).Type: ApplicationFiled: February 8, 2018Publication date: November 28, 2019Inventors: Mathew Gerald LYMAN, Lawrence DUGAN, Roald N. LEIF, Bonnee RUBINFELD, Brian E. SOUZA, Carlos A. VALDEZ
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Publication number: 20190359563Abstract: The present invention relates to novel substituted benzene disulfonamides, as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6? and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6? to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.Type: ApplicationFiled: January 11, 2018Publication date: November 28, 2019Inventors: Herbert Waldmann, Pablo Antonio Martin-Gago, Sandip Murarka, Christian Klein, Philippe Bastiaens, Alfred Wittinghofer
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Publication number: 20190359564Abstract: The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.Type: ApplicationFiled: August 7, 2019Publication date: November 28, 2019Applicants: THE UNIVERSITY OF QUEENSLAND, THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLInventors: Luke O'NEILL, Rebecca COLL, Matthew COOPER, Avril ROBERTSON, Kate SCHRODER