Abstract: An autoinjector includes a case adapted to hold a medicament container having a needle, a needle shroud telescopically coupled to the case, and a plunger rotationally and slidably disposed in the case. The needle shroud is movable between a first extended position relative to the case in which the needle is covered and a retracted position relative to the case in which the needle is exposed. The plunger is rotatable relative to the case between a first rotational position in which the plunger is engaged to the case and a second rotational position in which the plunger disengages the case. The needle shroud is operably coupled to the plunger. When the needle shroud translates from the first extended position to the retracted position, the plunger rotates from the first rotational position to the second rotational position.

Abstract: Syringe attachments and syringes have particular suitability to the precision dispensing of small amounts of high viscosity materials, such as dermal fillers. An attachment may include a main body having an assist feature that includes a wheel and pinion gears on each side of the wheel which engage respective racks on the syringe body. A mechanical advantage may be provided to the user as the wheel is rotated relative to the syringe body and racks. Syringes and attachments may include precision position indicators viewed from multiple positions to enable a user to determine plunger position and the amount of dispensed contents with precision. An alternative configuration attachment may be slidably secured to a syringe to permit a user to operation the syringe from a lateral position using sliding movement of the thumb and fingers of one hand, for example. This configuration may be particularly suitable for self-administered insulin injections.

Abstract: An administration instrument includes an injection button which can be pressed at an angle that is not parallel to a needle with respect to a direction in which the needle is inserted into skin. As a result, it is possible to prevent a force of pressing the injection button from being transmitted in the direction in which the needle is inserted into the skin deeper than initial insertion of the needle, thereby achieving an administration under a stable state.

Abstract: The present disclosure relates to a disposable injection needle, including: a needle mount, having a tube needle; a first sleeve, one end of which is suitable for connecting to the needle mount to form receiving space, and the other end of which is provided with a first opening; a second sleeve, one end of which is located inside the receiving space, and the other end of which having a second opening extends out from the first opening, wherein the second sleeve is axially slideable; an elastic element adapted to allow the second sleeve to move axially toward outside the receiving space, wherein: the second sleeve is provided with a sleeve guiding portion, and the needle mount is provided with a guiding engagement portion, the sleeve guiding portion engages with the guiding engagement portion to guide the circumferential rotation of the second sleeve based on axial movement of the second sleeve toward inside of the receiving space; the first sleeve is provided with a blocking member and the second sleeve is pr

Abstract: An automatic injector dispenses a predetermined dose of medicament without a user having to manually force the needle into an injection site. The automatic injector includes a needle cover having a locked retracted position with respect to the injector housing prior to a medicament dispensing operation. The needle cover is operative to engage an injection site prior to a medicament dispensing operation.

Abstract: A transdermal administration device includes an administration section and a support body. The administration section includes a base having a base surface and a projection protruding from base surface and having a peripheral surface, the projection including a flow path which extends through the projection to the peripheral surface and is open to the peripheral surface. The support body includes a plurality of support sections configured to abut a target of administration. When viewed in a direction facing base surface, the plurality of support sections surround the base surface with a gap between the adjacent support sections and between the base surface and the support sections. The transdermal administration device is configured to displace the projection relative to the support sections from a position in a space surrounded by the plurality of support sections toward outside the space in an extending direction of the projection.

Abstract: Some embodiments are directed to a needle assembly including at least N injection needles where N is at least four and a multiple of two. The needle assembly also includes a first liquid port adapted to be connected to an injection device, and N second liquid ports connected to one of the N injection needles. N/2 main liquid pathways each have an entrance connected to the first liquid port and an exit, further including N/2 secondary liquid pathways that have two extremities each opening on one of the N second liquid ports, and a mid portion connected to the exit of one of the main liquid pathways. The main liquid pathways and the secondary liquid pathways define N liquid flow paths between the first liquid port and the N second liquid ports dimensioned so a pressure drop between them is similar.

Abstract: Improved apparatus for use with medication in fluid form, which is particularly beneficial for medications having a relatively high viscosity. The disclosed syringe adapter has an opening that is relatively large, as compared to a conventional needle, and thus affixing the disclosed syringe adapter to a syringe improves syringeability of higher-viscosity medications. When the disclosed syringe adapter is affixed to a pistol-grip or tab-handled syringe, the medication withdrawn into the pistol-grip syringe can be more easily administered from the syringe barrel. In some embodiments, the syringe adapter will be replaced with a needle prior to injecting the medication, while in some other embodiments, the needle is affixed to the in-place syringe adapter for the injection. In yet other embodiments, the needle is affixed to a needle holder that, in turn, is affixed to the in-place syringe adapter for the injection.

Abstract: Apparatus for use with medication in fluid form, which is particularly beneficial for medications having a relatively high viscosity. The disclosed syringe adapter has an opening that is relatively large, as compared to a conventional needle, and thus affixing the disclosed syringe adapter to a syringe improves syringeability of higher-viscosity medications. When the disclosed syringe adapter is affixed to a pistol-grip or tab-handled syringe, the medication withdrawn into the pistol-grip syringe can be more easily administered from the syringe barrel. In some embodiments, the syringe adapter will be replaced with a needle prior to injecting the medication, while in some other embodiments, the needle is affixed to the in-place syringe adapter for the injection. In yet other embodiments, the needle is affixed to a needle holder that, in turn, is affixed to the in-place syringe adapter for the injection.

Abstract: A system and method for monitoring the pressure of an injection site, utilizing a fluid operating in the laminar regime flowing through a calibrated tube, and measuring a pressure at one end of the calibrated tube with a pressure sensor, as well as a fluid velocity with a flow sensor, such as an elastic filament velocimeter, that comprises a nano-scale sensing element. Additional elements may be utilized, including the use of data acquisition units, processors, user interfaces, pumps, syringes, and control loops.

Abstract: A sheath is provided for enclosing at least a portion of a catheter hub or other medical article to inhibit access to a lumen through the catheter hub. The sheath may comprise one or more portions that can be folded, wrapped, or otherwise positioned over or around the catheter assembly. The sheath could be used on a variety of medical articles including: a needleless valve or connector; an overlying cap on top of the valve or connector; administration tubing; a side port or connector on the side port; and any overlying cap on the side port or connector.

Abstract: A closure (100) for a container (6) is disclosed. The closure comprises a fixture (11) for attaching the closure to the container, a medicament port (14) for receiving a medicament dispenser (2) and discharging a medicament from the dispenser within an internal volume of the container, an air inlet port (5) for drawing air into the container, a mouthpiece (3) and a valve (4). The valve has an open position which permits air to be drawn from the internal volume of the container into the mouthpiece when a user inhales, and a closed position which seals the mouthpiece from the container and permits air exhaled by the user into the mouthpiece to be vented to atmosphere.

Abstract: A system containing a sensor suitable for pilot respiration inhalation gas data collection and a sensor suitable for pilot respiration exhalation gas data collection can be interfaced to a host computer or operate autonomously. The system or sensor components thereof can be used as a research tool for in-flight monitoring of physiologic effects on pilots' performance caused by the unique conditions faced during flight, in addition to human factors engendered during the course of their duty (fatigue, sleep loss, etc.).

Abstract: A ventilator (10) for use by a clinician in supporting a patient presenting pulmonary distress. A controller module (20) with a touch-screen display (26) operates a positive or negative pressure gas source (40) that communicates with the intubated or negative pressure configured patient through valved (46) supply and exhaust ports (42, 44). A variety of peripheral, central, and or supply/exhaust port positioned sensors (54) may be included to measure pressure, volumetric flow rate, gas concentration, transducer, and chest wall breathing work.

Abstract: A resuscitator mouth shield assembly for protecting a caregiver from bodily fluids during CPR includes a resuscitation bag that has a hose extending toward a face cup. A coupler releasably engages the resuscitation bag and a panel is rotatably coupled to the coupler. The panel is spaced from the resuscitation bag when the coupler is positioned on the resuscitation bag. Moreover, the panel is positioned between a patient's face and a caregiver when the resuscitation bag is positioned on the user's face. In this way the panel inhibits bodily fluids that are expelled from the patient from contacting the caregiver.

Abstract: A closed suction cleaning system includes an interface coupled to a main body inlet of a multi-port tube-connector assembly for coupling to an endotracheal tube. A catheter main body includes a distal inflatable element positioned along a distal end portion of the catheter main body. An input module is located at a proximal end of the catheter main body. The input module includes a flow regulator with a mechanical user control element. In a first configuring step, the flow regulator simultaneously regulates suction through the catheter main body and inflation of the distal inflatable element. After a second configuring step, the flow regulator and mechanical user control element may regulate suction through a suction lumen but not cause inflation of the distal inflatable element. A pliable sleeve inhibits contamination of a portion of the catheter main body from an external environment.

Abstract: Endotracheal tube securement systems (100) include one or more base articles (110) for securing the system to a patient's face and one or more coupling articles (120) having one or more anchor sections (130) configured to be repositionably coupled to the one or more base articles, while also including a capture section (140) configured to secure the coupling article to an endotracheal tube. The one or more anchor sections of the one or more coupling articles can be repositioned on the one or more base articles without removing the one or more base articles from the skin or even changing the one or more base articles on the skin.

Abstract: An adapter configured to allow interconnection of a device input connector (DIC) having a first connector configuration and an consumable end connector (CEC) having a second connector configuration, the adapter including a first end having a first connector mateable with the DIC, a second end configured to receive at least part of the CEC, a locking mechanism configured to lock the CEC to the adapter, and a release mechanism configured to release the CEC from the adapter.

Abstract: A vent arrangement for a respiratory pressure therapy device may include one or a plurality of vents configured with a variable aperture for communicating a flow of breathable gas. The vent arrangement may be configured with a cross section profile exposed to the flow of breathable gas communicating through the vent that does not change as the aperture size changes. A vent arrangement may include a plurality of the vents and the aperture size of each vent may be controlled independently or together, and may be controlled according to one or more input signals from one or more sensors. Examples of suitable input signals include flow, pressure, noise, accelerometer outputs, orientation of a patient or presence of any obstructions. A patient interface or an air circuit may include the vent arrangement, or the vent arrangement may be configured to connect with a patient interface or an air circuit.

Abstract: A sleep assistance device is provided-for, including a contactless biometric sensor, a processor, memory, and a speaker. The processor detects a user's sleep state by reading signals from the contactless biometric sensor. The processor may then initiate a wind-down routine upon detecting a sleep-readiness state, including playing relaxing sounds or playing a respiration entrainment sound. The processor may also play noise-masking sounds upon detecting that a user has fallen asleep and seamlessly transition between the sounds played during the wind-down routine and the noise-masking sounds.

Abstract: An operating method of a massage chair comprising: driving the massage chair according to a massage mode; acquiring a user state; when he user state has a sleep mode, changing the massage mode to the sleep mode and driving the massage chair according to the changed sleep mode, and controlling an object related to the sleep mode to be adjusted; and driving the massage chair according to an optimal sleep mode by learning an artificial neural network (ANN) so as to acquire the optimal sleep mode corresponding to sleep habit pattern data in the sleep mode.

Abstract: A catheter assembly package includes a hydrating sleeve and a catheter disposed in the hydrating sleeve, the hydrating sleeve and the catheter enclosed in a sealed package. A coating can be disposed on an outer surface of the catheter and in contact with an inner surface of the hydrating sleeve. The hydrating sleeve can include a fluid and an outer foil layer, and the fluid can be confined to the hydrating sleeve. The sealed package can enclose the hydrating sleeve in a first compartment and the catheter in a second compartment.

Abstract: A catheter and package combination including a package having opposed front and rear panels that are sealed together to define a sealed interior cavity. The package also has top and bottom edges and opposed side edges. The cavity has a first height extending in a direction between the top and bottom edges. The front and rear panels are configured to tear adjacent to one of the side edges in the direction between the top and bottom edges to form an opening in communication with the cavity wherein the opening has a second height in the direction between the top and bottom edges that is smaller than the first height of the cavity. A urinary catheter in a compact configuration is disposed within the cavity.

Abstract: Medical devices and systems comprising electrical traces are provided. The medical device comprises a sheath body (120) comprising an inner wall, an outer wall, and a central major lumen (20) extending through the sheath body (120) along a longitudinal axis. The central major lumen is defined by the inner wall. The medical device further comprises at least one outer lumen (38) extending through said sheath body, wherein the at least one outer lumen (38) is disposed between the inner wall and the outer wall, at least one electrode (14) coupled to a distal portion of said sheath body (120), and at least one electrical trace (44). Each of the at least one electrodes (14) is coupled to at least one electrical trace (44), and the electrical trace (44) is disposed between the inner wall and the outer wall.

Abstract: A hub defines a lumen with a longitudinal axis along the length of the hub. An outer surface of a distal portion of the hub tapers inwardly toward the longitudinal axis as the distal portion extends distally. A strain relief includes a proximal portion configured to receive the distal portion of the hub. The strain relief defines a lumen that substantially aligns with the hub lumen when the proximal portion receives the hub. The hub and/or strain relief are configured to be fixedly attached to a catheter body such that a catheter body lumen substantially aligns with the hub lumen and the strain relief lumen when the strain relief receives the distal portion of the hub. Outer surfaces of the strain relief and hub define substantially similar distances to the longitudinal axis along an interface between the two outer surfaces when the strain relief receives the hub.

Abstract: A flushable catheter assembly includes a catheter shaft having proximal and distal end portions. The catheter may include a funnel assembly associated with the distal end portion of the catheter shaft and/or an introducer cap assembly associated with the proximal end portion of the catheter shaft. A groove is defined along at least a portion of an outer perimeter of the funnel assembly or introducer cap assembly, with the groove being configured to receive at least a portion of the catheter shaft for wrapping the catheter shaft around the outer perimeter when disposing of the catheter. Instead of (or in addition to) a groove, one or more channels may pass through the funnel assembly to receive a portion of the catheter shaft for securing the catheter shaft to the funnel assembly for disposal. The catheter assembly and/or its individual components may be formed of a water disintegrable material.

Abstract: The present disclosure teaches a medical device and method of use, employing a tube which is composed of segments and bends capable being configured into unique shape that allows said device to use the lesser (inferior) curve of aortic Arch and other vessel structures as as fulcrums of support for a guide catheter, for subsequent prevention of recoil and displacement thereof, while delivering additional catheters or devices into the distal branches of the great vessels. A method for using same.

Abstract: A catheter having a proximal end portion having gaps between axially adjacent portions of an element wire where an inner layer is joined to an outer layer through the gaps; and a distal end portion where the axially adjacent portions of the element wire come into contact with each other, and a cavity is provided between the inner layer and a coil body. The catheter has excellent followability to a guide wire and is capable of efficiently transmitting a pushing force and/or rotational force from an operator to the distal end of the catheter.

Abstract: A catheter assembly includes a catheter having a proximal end and a distal end; an expandable device releasably attached to the catheter near the distal end; a generally tubular constraining sleeve extending around and compressing the device to an outer peripheral dimension suitable for endoluminal delivery; a tip fixedly secured to the distal end of the catheter; and a bridge member disposed between the tip and the expandable device so as to fill a gap therebetween as the catheter assembly is bent during endoluminal delivery of the expandable device to a treatment site.

Abstract: Provided is a catheter fixing band for fixing a tube bent and connected to a catheter to the catheter fixing band. According to the present disclosure, a catheter fixing band includes: a body detachably fixed to a human body and having a catheter hole open to expose a portion of the human body; and a cover unit detachably attached to the body to open or close the catheter hole, in which the cover unit includes a fixing member fixing the catheter to a predetermined position of the cover unit, and has a shape forming integral concept in relation to flow of fluid in the catheter when the cover unit covers the catheter hole and the catheter is fixed to the fixing member.

Abstract: The disclosed medical dressing has a dressing body and a flap. The dressing body has a first major surface and opposite second major surface containing a skin-contact adhesive. The flap has a fixed end integrally connected to the dressing body and a movable free end. The second major surface of the flap comprises a securing adhesive for contact with the first major surface of the dressing body.

Abstract: A catheter assembly includes a catheter and an inner needle inserted through the catheter. The catheter has a catheter body and a flexible portion that is provided at a distal portion of the catheter body, includes a most distal portion of the catheter, and is more flexible than the catheter body.

Abstract: A PIVC includes a catheter adapter having a catheter that extends distally from the catheter adapter, and an introducer needle that inserts through the catheter. The introducer needle has a grip component at a proximal end of the introducer needle. The grip component extends outwardly and distally to form a winged grip adjacent the catheter adapter when the introducer needle is inserted within the catheter. The grip component can be rotatable within the catheter adapter to allow repositioning of the winged grip with respect to the catheter adapter.

Abstract: A delivery sheath includes an outer tubular layer and an initially folded inner tubular layer. When an implant passes therethrough, the outer tubular layer expands and the inner tubular layer unfolds into an expanded lumen diameter. The sheath may also include selectively placed longitudinal support rods that mediate friction between the inner and outer tubular layers to facilitate easy expansion, thereby reducing the push force needed to advance the implant through the sheath's lumen.

Abstract: A guidewire system for spine surgeries includes a first guidewire portion having an elongate first guidewire body with a distal end and a proximal end. A threaded male fastener at the distal end of the first guidewire body is configured to fasten to a vertebra of a spine of a subject and a threaded female coupler at the proximal end of the first guidewire body defines a threaded opening. The guidewire system includes a second guidewire portion having an elongate second guidewire body with a distal end and a proximal end. A threaded male coupler at the distal end of the second guidewire body is configured to thread into the threaded female coupler of the first guidewire portion to fasten the second guidewire portion to the first guidewire portion to form an elongate guidewire.

Abstract: A non-compliant medical balloon comprises a base balloon including a pair of spaced-apart, generally conical end sections and a generally cylindrical center section connected therebetween. A braided fabric sleeve surrounds at least a portion of the base balloon, wherein the sleeve is formed of at least three substantially inelastic fibers intertwined in such a way that no two of the three fibers are twisted exclusively around one another. The sleeve is permanently affixed to the outer surface of the base balloon so as to prevent excessive expansion of the base balloon when the base balloon is internally pressurized.

Abstract: A balloon catheter which allows for faster preparation and more effective purging of air within the catheter, while also providing a more space efficient design, wherein the balloon catheter includes a tubular outer member and a tubular inner member disposed in the lumen of the outer member such that the outer member and inner member define an annular fluid path between them. A balloon is secured to and circumferentially surrounds an outer surface of the distal portion of the outer member. A tubular seal is disposed circumferentially around the inner surface of the distal portion of the outer member. The inner member is movable longitudinally relative to the outer member from a non-sealing position in which the annular fluid path is open, and a sealing position in which the distal portion of the inner member contacts the seal thereby sealing the annular fluid path at the seal.

Abstract: A balloon catheter which allows for faster preparation and more effective purging of air within the catheter, while also providing a more space efficient design, wherein the balloon catheter includes a tubular outer member and a tubular inner member disposed in the lumen of the outer member such that the outer member and inner member define an annular fluid path between them. A balloon is secured to and circumferentially surrounds an outer surface of the distal portion of the outer member. A tubular seal is disposed circumferentially around the outer surface of the distal portion of the inner member. The inner member is movable longitudinally relative to the outer member from a non-sealing position in which the annular fluid path is open, and a sealing position in which the distal portion of the outer member contacts the seal thereby sealing the annular fluid path at the seal.

Abstract: An adjustable hydrocephalus valve. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. § 1.72(b). As stated in 37 C.F.R. § 1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

Abstract: Surgical devices with integrated visualization and cauterization are described herein where such devices include an elongate structure having a central lumen and an expandable space-creating structure having at least one expandable leaflet mounted in the vicinity of the distal end and is configured for placement within a mammalian body proximate to a therapeutic target. Also included is a proximal terminal having an actuator mounted in the vicinity of the proximal end and is configured to remain outside of said body and provide an actuation mechanism for actuating the space-creating structure. Additionally, at least one fluid connector and said central lumen is in fluid communication between an interior of the expandable space-creating structure and the at least one fluid connector.

Abstract: A dilation device for an intrabody lumen, for example, a urethra partially occluded by an enlarged prostate in the form of a curved element configured to be implanted around the lumen and add resilience to the lumen, and a method for dilating such a lumen by implanting a dilation device around the outside of the lumen with at least part of the dilation device embedded in surrounding, thereby preventing clinically significant compression of the lumen. Also, an implantation device for such a dilation device in the form of a mounting device configured to carry the dilation device; and a releasably attached movable holder, with the mounting device and holder configured to deliver the dilation device though a working channel to a desired position in a lumen, and to implant the dilation device through a wall of the lumen to a position surrounding the lume.

Abstract: A method of treating a sinus cavity of a subject includes advancing a distal portion of a light source through a drainage pathway of a sinus cavity and into the sinus cavity and visually observing a transdermal light emitted from the light source. A distal portion of a substantially rigid inner guide member of a balloon dilation catheter is advanced into the drainage pathway, the balloon dilation catheter including a movable shaft including a balloon that is slidably mounted on the substantially rigid inner guide member. The movable shaft and balloon are advanced distally over the substantially rigid inner guide member to place a portion of the balloon in the drainage pathway whereby the balloon is inflated.

Abstract: An expandable tissue dilator for dilating tissue around a spinal column includes a housing and a shaft at least partially positioned distally of the housing and adapted to pierce a tissue around the spinal column. An expandable member attached to the housing expands around a portion of the shaft to dilate the pierced tissue in a single-pass dilation resulting in a reduction of any traumatic impingement of nerves or muscle tissue and reduction in procedure time.

Abstract: Apparatus for delivering a therapeutic agent to a uterine cavity including an elongated member having a fluid channel for passage of the therapeutic agent into the uterine cavity, a dispensing member extending distally of the elongated member and having at least one perforation for passage of the therapeutic agent into the uterine cavity into contact with the endometrium. An infusion line is in communication with the fluid channel for passage of a fluid into the uterine cavity to assess leakage to determine integrity of the uterine cavity prior to passage of the therapeutic agent into the uterine cavity.

Abstract: A portable transdermal administration patch apparatus comprises a communication control device and a pharmaceutical device which is fixed to and arranged at a lower end of the communication control device and electrically connected to the communication control device. The communication control device is formed of a micro-battery, a wireless control device and a micro-controller which are electrically connected. The preparation of the patch apparatus is achieved by: the preparation of medicinal patches and non-medicinal patches, the mounting of electrodes, interfacing with a micro-controller, and the communication control system, and starting administration.

Abstract: The invention relates to methods of treating baldness, treating alopecia, promoting hair growth, and/or promoting hair follicle development and/or activation or stimulation on an area of the skin of a subject (for example, a human) by subjecting said area of the skin to integumental perturbation. Integumental perturbation can be used in combination with other treatments for promoting hair growth. The invention provides devices for integumental perturbation for promoting hair growth, and provides pharmaceutical compositions for use in combination with integumental perturbation for promoting hair growth.

Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Abstract: A microneedling device includes a microneedle cartridge that extends needles at a predetermined angle, rather than perpendicular to the centerline of the device.

Abstract: A mold assembly for forming a microneedle array via variothermal extrusion at a laser-drilled mold.

Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.