Abstract: An apparatus for automatically disinfecting piping for medical uses includes a main controller including a control center module, an administration controller, and an electric valve controller; a disinfection solution machine connected to a main pipe including first branch pipes each provided with an administration motor control valve and connected to medical devices, second branch pipes each connected to the first branch pipe, and drains each connected to the first branch pipe, first electric valves each is provided between the medical device and the first branch pipe, second electric valves each is provided in the second branch pipe, third electric valves each is provided in the drain; and a reverse osmosis water filter being in fluid communication with a purified water reservoir having an outlet connected to the first branch pipes, and a feedback end connected to the second branch pipes.

Abstract: A device capable of stably obtaining gas of a sterilizer containing hydrogen peroxide for a long time is provided. A cleaning device that cleans a heating surface that gasifies a sterilizer of a gasifier for a sterilizer is provided, and after an operation for a fixed time period, the heating surface is cleaned.

Abstract: A combination salt lamp and aroma/essential oil diffuser includes: a housing with an outlet for mist exiting the housing and an open space, a water tank inside the housing for storing liquid having a passageway that connects to the mist outlet and can disperse nebulized mist outwardly, a nebulizing assembly within the water tank to nebulize the liquid in the water tank, a salt crystal mineral that sits in the open space of the housing, a heating assembly with a heating element adjacent the salt crystal, a fan assembly inside the housing, and a power assembly for the nebulizing assembly, the heating assembly, and the fan assembly.

Abstract: The present invention relates to the use of zinc treated precipitated calcium carbonate (PCC), which is obtained by slaking calcium oxide with water to obtain a calcium hydroxide slurry, carbonating the calcium hydroxide slurry, and adding a Zn2+ ion provider before and/or during the carbonation, in hygienic products, to the hygienic products comprising said zinc treated precipitated calcium carbonate as well as to a process for the preparation of such hygienic products.

Abstract: In various aspects, the invention provides materials comprising a hydrophobically-modified biopolymer, such as hm-chitosan, as well as methods of making the materials, including textile materials. The hm-biopolymer can be a polysaccharide and may have antimicrobial properties including against antibiotic-resistant bacteria, providing opportunities to combat microbial persistence in clothing and at wound sites.

Abstract: Provided is a medical article with improved moisture vapor transmission rate of the pressure sensitive adhesive layer with a miscible composition. The medical article has a backing, a pressure sensitive adhesive layer with acid-functional groups or basic-functional groups, an MVTR-modifying composition that is basic when the PSA comprises an acidic-functional group or is acidic when the PSA comprises a basic-functional group, and a filtration layer disposed between the MVTR-modifying layer and the PSA layer. The MVTR-modifying composition is miscible with the PSA, and contact between the MVTR-modifying composition and the PSA causes an acid-base reaction to form a poly-salt and increase moisture permeability of at least a portion of the PSA layer.

Abstract: The present disclosure describes a medical construct. The medical construct includes a first layer comprising an array of collagen fibers, the first layer forming a core of the medical construct, and a second layer comprising a plurality of braided collagen fibers, wherein the second layer surrounds the core of the medical construct. In some embodiments, the medical construct may further include a third layer comprising a plurality of braided collagen fibers, wherein the third layer surrounds the second layer. Methods of manufacturing a medical construct also provided.

Abstract: A method of reducing surgical site infection (SSI), using a coated medical device having a tissue penetrating surface and an abradable coating on the medical device comprising at least one antimicrobial agent in the coating.

Abstract: The disclosure provides settable surgical materials that are useful, for example, as cement and/or adhesive compositions or as tissue void or space fillers. The invention also provides related compositions, including surgical kits and packages, as well as methods of making and using the settable surgical materials described here.

Abstract: The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.

Abstract: This invention provides a hydrogel surgical dressing product having a designed multi-dimensional flexible hydrophilic structure-linkage composite, comprising: a hydrogel cushion layer, and a multiple of hydrophilic microsphere, wherein said multi-dimensional flexible hydrophilic structure-linkage composite comprising a hydrophilic multi-dimensional flexible structure-linkage membrane, and a multiple of structure-linkage holes positioned into said hydrophilic multi-dimensional flexible structure-linkage membrane, and the sizes of structure-linkage holes changed with the degree of compelling force, resulting in a multi-dimensional flexible structure-linkage relationship and a consolidating structure.

Abstract: A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.

Abstract: A method of improving the fatigue life of a superelastic medical device includes applying a compressive stress to a fatigue critical location of a medical device comprising a superelastic nickel-titanium alloy, where the compressive stress induces a compressive strain of greater than 9% in the fatigue critical location. After inducing the compressive strain, the compressive stress is released. A tensile stress is applied to the fatigue critical location of the medical device, where the tensile stress induces a tensile strain of greater than 9% in the fatigue critical location. After inducing the tensile strain, the tensile stress is released. After application and release of each of the compressive stress and the tensile stress, the fatigue critical location includes a non-zero amount of residual strain, and the medical device may exhibit improved fatigue properties.

Abstract: Gold implant having a cross-section in the range of 20-100, preferably in the range of 20-40 ?m for use in therapy to prevent or reduce capsular contracture. Further, the invention relates to a method of producing a gold-coated implant.

Abstract: The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles.

Abstract: The present invention relates to a supermatrix of synthetic niches comprising at least two matrices of niches wherein each matrix comprises n×m niches and wherein the distance (d) between a matrix and the other is greater than zero and wherein in each matrix every synthetic niche has one or more walls in common with the others synthetic niches of the matrix. A support for the culture of cells that includes at least one supermatrix and the use of said supermatrix or support for the in vitro culture of cells, in particular stem cells, or for the in vivo implant in a subject in order to promote tissue or organ regeneration through cell repopulation are also within the scope of the present invention.

Abstract: Provided herein is a novel bioresorbable polymer composite for bone soft tissue fixation including i) Silk fibroin in an amount of 5 to 30%, ii) a bioresorbable polymer matrix in an amount of 40 to 90%, and iii) magnesium oxide or other ceramic fillers in an amount of 5 to 30%.

Abstract: The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

Abstract: The present invention provides for collagen and collagen like peptide based hydrogels, corneal implants, filler glue and uses thereof. The invention represents an advancement in the field of hydrogels, corneal implants, filler glue based on collagen and collagen like peptides. The invention discloses collagen and novel collagen like peptides crosslinked with DMTMM and their use in preparation of hydrogel, corneal implant and filler glue which are highly efficacious and robust as compared to existing corneal implants. Further, the invention relates to method of treating corneal defects and diseases.

Abstract: A polytetrafluoroethylene tube is provided and has a thickness of 0.1 mm or less, a tensile elongation at break of 350% or more, and a melting energy of 0.6 J/g or more which is calculated from an endothermic peak at 370° C.±5° C. in a procedure of increasing a temperature in differential scanning calorimetry (DSC).

Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis-silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.

Abstract: Embodiments of a canister for a negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, the canister includes a receptacle for receiving wound exudate. A filter stack is interposed between the receptacle and the pump assembly and provides a fluid flow path therebetween. The flow path is more easily navigable by gas than by liquid, thereby allowing the pump assembly to apply a negative pressure to the canister without aspirating wound exudate into filters housed within the filter stack.

Abstract: A treatment system for debriding a treatment area of a tissue site and applying negative pressure is disclosed. In some embodiments, the treatment system may include an ultrasonic bubble generator fluidly coupled to a negative-pressure source, fluid source, and a dressing. Fluid may be drawn from the fluid source to the ultrasonic bubble generator, whereby micro-bubbles and ultrasonic waves may be generated in the fluid before the fluid is instilled to the dressing.

Abstract: A high efficiency cardiac support system is suitable for chronic use in treating heart failure, wherein the system includes an implantable rotary blood pump, an implantable power module, a wireless power transfer subsystem, a patient monitor, and a programmer. In a cardiac support system, the cumulative efficiencies of the components of the system are capable of providing therapeutically effective blood flow for a typical day of awake hours using the energy from a single wireless recharge of an implanted rechargeable energy source. Moreover, the implantable rechargeable energy source may be recharged during a normal sleep period of 8 hours or less. The system may provide full or partial cardiac support without the need for external wearable batteries, controllers, or cables.

Abstract: A handheld personal communication apparatus for dialysis includes a reader to (i) read a marking displayed on a dialysis fluid container to acquire data concerning at least one of a dialysis fluid type or a dialysis fluid volume from the marking, and/or (ii) receive a patient weight signal from a weight scale; a processor using at least one of the dialysis fluid type, dialysis fluid volume, or patient weight to determine a dialysis dwell time for at least one cycle of a dialysis therapy, the dialysis dwell time being a time to achieve, over the at least one cycle, at least one of (a) a specified ultrafiltrate level, (b) a urea removal level, or (c) a creatinine removal level; and an output interface providing an indication to the patient of a completion of the dialysis dwell time.

Abstract: A filter container for separating cells includes a tubular filter member-housing part having an opening at each longitudinal end, a liquid inlet port on a first opening end side of the filter member-housing part, a liquid outlet port on a second opening end side of the filter member-housing part, a first filter-pressing part on the first opening end side, and a second filter-pressing part on the second opening end side. The first filter-pressing part includes three or more first protrusions, and the ratio of an area of a polygon formed by individually connecting the tips of the three or more first protrusions to a cross-sectional area of an inner space of the filter member-housing part at the first protrusion position is controlled within a preset range.

Abstract: A femoral arterial ECMO cannula is provided with a balloon that has dual flow and which provides arterial body blood flow during femoral ECMO (Extra Corporeal Membrane Oxygenation).

Abstract: An end effector for use with a surgical instrument includes a plurality of staples, an agent reservoir comprising a medical agent, a dispensing passage configured to convey the medical agent from the agent reservoir to tissue, and a firing system which includes a cutting member, a movable member, and a firing member, wherein the firing system is configured to cooperatively move the movable member and the firing member to simultaneously fire the plurality of staples and dispense at least a portion of the medical agent near the cutting member owing to the advancement of the firing member.

Abstract: An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

Abstract: Provided is a method for delivering a medical fluid. The method includes delivering a fluid volume, which includes contrast and/or a flush fluid, at a preselected total volumetric flowrate during a first duration of a fluid delivery procedure. The amount of the contrast agent and the flush fluid in the fluid volume can be controllably varied during the first duration of the fluid delivery procedure so as to substantially maintain a preselected total volumetric flowrate throughout the first duration of the fluid delivery procedure. Also provided is a fluid delivery system capable of performing this method.

Abstract: A method for using CO2 as a contrast material in medical imaging procedures is disclosed. The method includes providing a source of pressurized CO2. The step of providing includes connecting the source of pressurized CO2 to a compressed gas unit for controlling delivery of the CO2. The method also includes regulating pressure of the CO2 delivered by the compressed gas unit, transmitting the pressurized CO2 from the compressed gas unit to a control valve assembly for delivery to a patient in controlled dosages, and sequentially processing the CO2 with the control valve assembly and delivering the CO2 to the patient as a contrast media.

Abstract: A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament. The fluid delivery device may include one or more basal drive mechanisms to provide a basal delivery of one or more of the first and second medicaments. The fluid delivery device may further include one or more bolus drive mechanisms to provide a bolus delivery of one or more of the first and second medicaments.

Abstract: A device for transferring a fluid to and/or from a fluid container having a sealing member. The device includes a piercing member for penetrating the sealing member and an elongated body defining a longitudinal flow channel through which a fluid may flow into and/or out of the fluid container and at least one opening that communicates with the flow channel. The at least one opening is arranged to extend along at least 1% of the length (l) of the piercing member to ensure that at least part of the at least one opening is located substantially adjacent to the innermost side of a sealing member when the device is in use.

Abstract: A device for filling and priming syringes is provided and comprises a support base, an engagement seat defined on the support base to receive a rear end of a syringe barrel of a syringe provided with a sliding plunger, engaging means defined at the engagement seat to cooperate with the syringe barrel for firmly holding the syringe to the engagement seat, a first vacuum pump or compressor which is provided with a suction opening communicating with the engagement seat to generate an under-pressure in the volume comprised between the plunger and the engagement seat when the syringe is firmly engaged in the engagement seat, and a second vacuum pump or compressor which is provided with a discharge opening communicating with the engagement seat to generate an over-pressure in the volume comprised between the plunger and the engagement seat when the syringe is thinly engaged in the engagement seat.

Abstract: The syringe includes a hollow body with at least one free-floating piston and a plunger within the body, with the piston between the plunger and a proximal end of the body. A manifold is provided lateral to the body. The manifold leads to an input/output tip. The manifold includes a front port located between the piston and the proximal end of the body and a rear port spaced from the proximal end of the body. The manifold includes at least one flow path leading from the input/output tip to at least one of the front port and/or the rear port. A first fluid fills a rear chamber distal to the piston and then the manifold is adjusted to fill second fluid into a front chamber proximal of the piston, and then the manifold is adjusted to allow sequential delivery of the second fluid and the first fluid.

Abstract: A medicament delivery device is disclosed having a housing, an actuation mechanism capable of delivering doses of medicament from a medicament container and arranged with a delivery member, a shield, a guard movable within the housing, wherein the guard is operably connected to the actuation mechanism. A protective cap is releasably arranged on the housing and having a shield remover. A blocking element on the guard is movable between a blocking position and a release position and has an engagement surface to engage a proximal area of the housing. The blocking element engages with a surface of the shield remover to retain the blocking element in the blocking position. The engagement surface causes a blocking of the guard from movement and removal of the protective cap enables a movement of the blocking element to a release position when the engagement surface engages the proximal area allowing the member guard to move.

Abstract: A method for needle-free injection and a needle-free injector device are provided. The method includes automatically injecting an injectable into a surface in contact with the needle-free injector in response to a skin compression parameter of an end of the needle-free injector. A needle-free injector device (102) includes predefined structures formed on it to inject an injectable through a non-porous material. The predefined structures engage an airlock mechanism such that an airlock in the non-porous material and operably coupled to the airlock mechanism can only be opened and closed to enable needle-free injection through the non-porous material without disrupting an integrity of the non-porous material by the needle-free injector device. Other functions, embodiments and methods for using and programming the needle-free injector device are also provided.

Abstract: Provided is a titanium filter for syringes and its manufacturing method, more particularly, a titanium filter for syringes which has an improved filtering power and high safety and its manufacturing method. The titanium filter for syringes comprises: a first body having a hollow hole formed on the inner side thereof; and a second body configured to extend in the longitudinal direction of the first body and to cover one side of the hollow hole, wherein the first body and the second body are composed of titanium powders.

Abstract: A feedback mechanism for an injection device that is configured to deliver a medicament to a user is described. The feedback mechanism comprises a piston and a fluid chamber, and the piston is adapted to move into the fluid chamber during use of the injection device. The feedback mechanism also has a damper that is arranged to damp movement of the piston, and an indicator that is arranged to provide feedback to the user after the piston has moved a pre-determined distance into the fluid chamber.

Abstract: A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners.

Abstract: An injection device has a dose controlling assembly, an operation assembly, an injection pushing assembly, and a clutch assembly. The dose controlling assembly has an outer tube, a dose controlling tube, a driving tube, a connection tube, and a dose controlling collar. The driving tube has a limiting portion. The dose controlling collar is mounted in the dose controlling tube and has a spiral limiting portion selectively engaged with the limiting portion of the driving tube. The operation assembly is mounted on a rear end of the dose controlling assembly. The injection pushing assembly is mounted on a front end of the dose controlling assembly. The clutch assembly is mounted in a front segment of the outer tube and is connected with the injection pushing assembly.

Abstract: A feedback mechanism for an injection device that is configured to deliver a medicament to a user is described. The feedback mechanism comprises an actuator and a fluid chamber having a restricted outlet. The actuator is adapted to urge fluid from the fluid chamber through the restricted outlet. The feedback mechanism also has an indicator that is adapted to provide feedback to the user after a predetermined volume of fluid has passed from the fluid chamber through the restricted outlet during use of the injection device.

Abstract: A device that regulates, monitors, and provides data on the progress of a large-volume injector during its injection sequence. The device comprises an injector and a monitor assembly. The injector has a syringe having a plunger, and a biasing device that biases the plunger through the syringe. The monitor assembly comprises a resistance unit configured to resist movement of the plunger, a gear connected to the plunger by the resistance unit, and a control unit configured to monitor the position, and regulate the rotation, of the gear. Wherein linear movement of the plunger causes the gear to rotate so that the control unit generates information on the position of the plunger.

Abstract: In an elongated casing, an active agent container connected to an injection needle can be shifted axially by a spring force. Auto-injectors which are sold or distributed filled and with the springs tensed have to be provided with a needle protecting cap to ensure the sterility of the injection needle. When such a needle protecting cap is removed as preparation for using the auto-injector, a tensile force can be exerted on the active agent container. Therefore, the active agent container comprising the injection needle must be prevented from being undesirably pulled forwards. At least one latching tongue prevents the active agent container from being prematurely shifted with respect to the casing, by abutting a flange arranged on a sliding sleeve which accommodates the active agent container. When the auto-injector is placed onto a person's skin, a needle protecting tube is shifted into the casing, forcing the latching tongue away from the flange and, thus, freeing the travel path for needle movement.

Abstract: A needle shield remover is presented having a generally tubular body with a longitudinal extension and a number of grip elements arranged at a distal area of the body, where the grip elements extend radially inwards from a circumference of the body. At least one longitudinally extending cut-out in the body and adjacent to the grip elements engage an outer surface of a needle shield when the needle shield remover is pushed onto the needle shield, where the at least one cut-out enables a generally radial outwardly bias of the grip elements during the pushing action to facilitate mounting of the needle shield remover on the needle shield.

Abstract: A syringe safety device is disclosed herein that comprises a shaft configured to support a barrel of a syringe, a guard configured to be disposed inside the shaft before the syringe is used and to extend outwardly from the shaft after the syringe is used, and a lock disposed between the guard and the shaft having a lock head disposed at a first end thereof, the lock head being disposed in a first aperture in the shaft before the syringe is used and in a second aperture in the shaft after the syringe has been used. A method of using the device also is described.

Abstract: A passive safety needle shield (300) is provided. The needle shield comprises a base (302) fixed to a proximal end of a needle, and an enclosure housing (304) initially disposed at a distal end of the needle, and enclosing the end of the needle. A hinged arm (306) connects the base (302) and the enclosure housing (304). The enclosure housing (304) is slidable along the needle length, and the hinged arm (306) flexes to permit the enclosure housing (304) to move along the needle as the needle is inserted into a user, thereby hiding the needle end, and providing support to the needle to avoid bends or buckles in the needle. The hinged arm (306) is biases in the initial position so that the enclosure housing (304) returns to the end of the needle as the needle is withdrawn.

Abstract: A medicament delivery device includes a main injection needle for injecting a medicament into the body of a patient. The medicament delivery device includes a pain reduction device for releasing a pain reduction agent into the body of the patient prior the medicament injection. The pain reduction device includes an array of microneedles.

Abstract: Provided is a warming device which can efficiently warm a blood product and inhibit a liquid in a warming flow path from exceeding an upper limit temperature thereof when liquid delivery of the blood product is stopped. The warming device includes the warming flow path in which the blood product flows and a heat plate which is in contact with the warming flow path to supply heat to the warming flow path. On the heat plate, a heater in a predetermined pattern corresponding to the warming flow path is disposed. The heater is disposed such that an amount of heat generation toward the warming flow path decreases in stages from an upstream side toward a downstream side in the warming flow path and that a decrease rate of the amount of heat generation at each of the stages decreases from the upstream side toward the downstream side.

Abstract: The disclosure relates to a laminar evaporator including an electrical resistance heating element for pulse heating and evaporation of an inhalationally receivable material distributed or distributable on the heating element surface by an electric heating current flowing or flowable in a laminar manner with at least two electrical contacts or poles for introducing the heating current into the resistance heating element, wherein the resistance heating element has at least one slot-shaped recess constricting lines of flux of an original electric field forming or formable between the at least two electrical contacts or poles and comprises a porous structure having a porosity of 70% or greater holding or capable of holding the material.