Abstract: Delivery devices, systems, and methods for delivering implantable leadless pacing devices are disclosed. An example delivery device may include an intermediate tubular member and an inner tubular member slidably disposed within a lumen of the intermediate tubular member. A distal holding section may extend distally of a distal end of the intermediate tubular member and define a cavity therein for receiving an implantable leadless pacing device. The device may further include a handle assembly including at least an intermediate hub portion affixed adjacent to the proximal end of the intermediate tubular member and a proximal hub portion affixed adjacent to the proximal end of the inner tubular member. A longitudinally extending groove having a proximal end and a distal end may be disposed in the intermediate hub portion. A first locking mechanism may be configured to releasably couple the intermediate hub portion and the proximal hub portion.

Abstract: Described herein are methods of electroporation that can include the steps of contacting a cell that is responsive to an EphA2 receptor ligand with an amount of an EphA2 receptor ligand and applying high-frequency irreversible electroporation to the cell. Also described herein are methods of treating cancer in a subject in need thereof, wherein the methods can include the steps of administering an amount of an EphA2 receptor ligand and applying high-frequency irreversible electroporation to a location on or within the subject.

Abstract: A nerve in a mammal is optogenetically transduced, wherein the nerve is susceptible to stimulus by selective application of transdermal light, and a light source is applied to dermis of the mammal at or proximate to the optogenetically transduced nerve, to thereby stimulate the nerve. A wearable device for optogenetic motor control and sensation restoration of a mammal includes a wearable support, a power source at the wearable support, a controller at the wearable support and in electrical communication with a power source, and a transdermal light source coupled to the controller.

Abstract: A device includes a shaft made of an electrically insulating material, RF electrodes axially spaced one from another by insulating gaps along an axial length of the shaft, a handle coupled to the shaft, and RF and electrical components coupled to the handle and in electrical communication with the RF electrodes. A peripheral shape of the shaft is triangular with rounded corners.

Abstract: Prophylactic stimulation and abortive electrical stimulation are delivered to a cranial nerve, including, e.g. an occipital or trigeminal nerve to treat symptoms of various conditions, including, e.g. occipital neuralgia or migraines.

Abstract: A controller delivers electrical stimulation therapy to a diaphragm through the one or more electrodes, and obtains a signal indicative of a pressure within an intrathoracic cavity from a pressure measurement source. The electrical stimulation therapy is defined by stimulation parameters. The controller obtains at least one additional signal indicative of a pressure within an intrathoracic cavity by changing at least one of the stimulation parameters, and delivering an electrical stimulation therapy to the diaphragm in accordance with the changed one of the plurality of stimulation parameters. The controller repeats the process of obtaining additional signals indicative of pressure based on a changing stimulation parameter by scanning through a range of values for the changing stimulation parameter.

Abstract: A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include one or more electrode leads coupled to an implantable pulse generator (IPG) and a tunneler system for subcutaneously implanting a proximal portion of the lead(s). The system may also include a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

Abstract: Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The devices comprise a housing and an energy source for generating an electric current and transmitting the electric current from the electrode through an interface and the outer skin surface of the patient to a selected nerve fiber within the patient as the interface contacts the outer skin surface. The electric current is sufficient to modulate the selected nerve fiber to at least one of treat or prevent at least one of gastroparesis, functional dyspepsia, or ileus in the patient.

Abstract: This application describes a miniature implantable neurostimulator system for sciatic nerves and their branches. The implanted miniature neurostimulator is implanted in the leg and stimulates these nerves for the treatment of urinary or bowel incontinence. The miniature implantable neurostimulator has a low duty cycle permitting a small size with medically-acceptable longevity. The system includes a wireless programmer and patient-activated key fob.

Abstract: An implantable medical device is configured to control a therapy module to couple a capacitor array comprising a plurality of capacitors to a plurality of extra-cardiovascular electrodes and control the therapy module to deliver a composite pacing pulse to a patient's heart via the plurality of extra-cardiovascular electrodes by sequentially discharging at least a portion of the plurality capacitors to produce a series of at least two individual pulses that define the composite pacing pulse.

Abstract: Methods and devices are disclosed for the non-invasive treatment of neurodegenerative diseases through delivery of energy to target nervous tissue, particularly the vagus nerve. The methods and devices transmit an electrical impulse transcutaneously through an outer skin surface of the patient to modulate activity of a selected nerve at the target region to inhibit inflammation, enhance an anti-inflammatory competence of a cytokine in the patient and treat the neurodegenerative disorder. The stimulation brings about reduction of neuroinflammation in patients suffering from conditions comprising Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction and postoperative delirium.

Abstract: An exemplary sound processor included in a cochlear implant system may include a control facility that represents a first frequency domain signal to a patient by 1) directing a cochlear implant included in the cochlear implant system to apply, during a first stimulation frame, a first monophasic stimulation pulse representative of a first temporal portion of the first frequency domain signal that corresponds to the first stimulation frame, the first monophasic stimulation pulse having a first polarity, and 2) directing the cochlear implant to apply, during a second stimulation frame that is temporally subsequent to the first stimulation frame, a second monophasic stimulation pulse representative of a second temporal portion of the first frequency domain signal that corresponds to the second stimulation frame, the second monophasic stimulation pulse configured to at least partially charge balance the first monophasic stimulation pulse and having a second polarity opposite the first polarity.

Abstract: This document discusses, among other things, systems and methods for robotically assisted implantation of an implant in a patient. A system includes an external positioning unit configured to engage an elongate member of the implant, and a control console communicatively coupled to the external positioning unit. The control console may have a user interface that enables a user to input motion control instructions. The control console may generate a motion control signal, according to a specific motion control instruction, to control the external positioning unit to propel the implant into a target implant site. The system may be used to robotically control the delivery and positing of a cochlear implant during a hearing-preservation cochlear implant surgery.

Abstract: The present disclosure provides a method and device for filtering sensor data. Signals from an array of sensor pixels are received and checked for changes in pixel values. Motion is detected based on the changes in pixel values, and motion output signals are transmitted to a processing station. If the sum of correlated changes in pixel values across a predetermined field of view exceeds a predetermined value, indicating sensor jitter, the motion output signals are suppressed. If a sum of motion values within a defined subsection of the field of view exceeds a predetermined threshold, indicating the presence of a large object of no interest, the motion output signals are suppressed for that subsection.

Abstract: A method is disclosed for programming a patient's stimulator device using an external device. The method obtains information such as a model at the external device, wherein the information is specific to the patient, wherein the information comprises a range or volume of stimulation parameters determined based on testing of the patient that preferably provide sub-perception therapy; and providing from the external device instructions for execution at the stimulator device, the instructions specifying an amplitude, a pulse width, and a frequency of stimulation pulses to be provided at one of more of electrodes in an electrode array of the patient's stimulator device, wherein the instructions vary over time at least one of the amplitude, pulse width, and frequency within the range or volume. Varying at least one of these parameters helps in preventing the patient's neural tissue from become habituated when compared to stimulation that is provided without variance.

Abstract: Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.

Abstract: A computer implemented method and system for detecting arrhythmias in cardiac activity are provided. The method is under control of one or more processors configured with specific executable instructions. The method obtains cardiac activity (CA) signals at the electrodes of an implantable medical device (IMD) in connection multiple cardiac beats and with different IMD orientations relative to gravitational force. The method obtains acceleration signatures at a sensor of the IMD that are indicative of heart sounds generated during the cardiac beats. The method obtains device location information at the IMD, with respect to the gravitational force during the cardiac beats. The method groups the acceleration signatures associated with the first and second set of cardiac beats into the corresponding one of first and second posture bins based on the device location information.

Abstract: An intracardiac ventricular pacemaker having a motion sensor is configured to produce a motion signal including an atrial systolic event and a ventricular diastolic event indicating a passive ventricular filling phase, set a detection threshold to a first amplitude during an expected time interval of the ventricular diastolic event and to a second amplitude lower than the first amplitude after an expected time interval of the ventricular diastolic event. The pacemaker is configured to detect the atrial systolic event in response to the motion signal crossing the detection threshold and set an atrioventricular pacing interval in response to detecting the atrial systolic event.

Abstract: Cardiac resynchronization therapy (CRT) delivered to a heart of a patient may be adjusted based on detection of a surrogate indication of the intrinsic atrioventricular conduction of the heart. In some examples, the surrogate indication is determined to be a sense event of the first depolarizing ventricle of the heart within a predetermined period of time following the delivery of a fusion pacing stimulus to the later depolarizing ventricle. In some examples, the CRT is switched from a fusion pacing configuration to a biventricular pacing configuration if the surrogate indication is not detected, and the CRT is maintained in a fusion pacing configuration if the surrogate indication is detected.

Abstract: Systems and methods for providing a trial neurostimulation to a patient for assessing suitability of a permanently implanted neurostimulation are provided herein. In one aspect, a trial neurostimulation system includes an EPG affixation device that secures the EPG to the patient when connected to a lead extending through a percutaneous incision to a target tissue location, while allowing for ready removal of the EPG for charging or bathing. In another aspect, the system includes an EPG provided with a multi-purpose connector receptacle through which the the EPG can deliver neurostimulation therapy to an implanted lead or the EPG can be charged. In yet another aspect, the EPG can include a multi-purpose connector receptacle that is alternatingly connectable with a plurality of differing connector to facilitate differing types of therapies with one or more neurostimulation devices, ground patches or various other devices, such as charging or testing devices.

Abstract: A wirelessly-powered medical system includes an intermediate energy transfer module configured to receive energy transferred from a main power source, a transferring magnetic resonator connected to the intermediate energy transfer module and configured to transmit a wireless power transfer signal, and a medical device configured for placement on, in, or in close proximity to a subject, the medical device requiring at least some input power to be fully operational, the medical device connected to a receiving magnetic resonator, wherein the transferring magnetic resonator is configured to exchange power wirelessly via the wireless power transfer signal with the receiving magnetic resonator.

Abstract: Programming a stimulator device to deliver a stimulation therapy at high-density parameter settings using a cathode-minimized electrode configuration determined to induce paresthesia over a patient pain pattern at low-density parameter settings.

Abstract: In some examples, a method for controlling delivery of cardiac therapy and cardiac sensing by a medical device system including electrodes for delivering the cardiac therapy may include storing, in a memory of the medical device system, a respective value for each of a plurality of cardiac therapy and/or sensing parameters and, in association with each of a plurality of heart position states, a respective modification of at least one of the cardiac therapy and/or sensing parameters. Such a method also may include determining a current one of the plurality of heart position states of the patient, modifying the at least one cardiac therapy and/or sensing parameter value according to the modification associated with the current heart position state, and controlling the delivery of the cardiac therapy and/or cardiac sensing according to the modified at least one cardiac therapy and/or sensing parameter value.

Abstract: In some examples, medical device systems that deliver anti-tachyarrhythmia shock(s) (e.g., defibrillation shock(s)) to a heart of a patient in coordination with the respiration of the patient. In one example, a medical device system including therapy generation circuitry configured to generate a defibrillation shock. The medical device system also includes processing circuitry configured to identify a time at which a respiratory volume of a lung of a patient is at approximately end tidal volume or less; and control the therapy generation circuitry to deliver the defibrillation shock to a heart of the patient at the time that the respiratory volume of the lung of a patient is at the approximately end tidal volume or less.

Abstract: A system and method for conservation of battery power in a portable medical device is provided. In one example, a processor arrangement includes a dual core processor having an ARM core and a DSP core. The portable medical device includes a monitor having the dual core processor, in communication with a belt node processor. The DSP core receives physiological data from the physiological sensor and sends the physiological data to the ARM core. The ARM core analyzes the physiological data to determine if a treatment sequence is necessary. The DSP core receives physiological data from the at least one physiological sensor and sends the physiological data to the ARM core, and also analyzes the physiological data to determine proper timing of the treatment sequence by the at least one therapy delivery device to synchronize at least one pulse of the treatment sequence with the physiological data.

Abstract: The present disclosure provides systems and methods for applying anti-tachycardia pacing (ATP) using subcutaneous implantable cardioverter-defibrillators (SICDs). An SICD implantable in a subject includes a case including a controller, and at least one conductive lead extending from the case. The at least one conductive lead includes a plurality of coil electrodes, wherein the SICD is configured, via the controller, to apply anti-tachycardia pacing (ATP) to the subject using the at least one conductive lead.

Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of tissue that include applying energy (e.g., electromagnetic energy) into the target tissue to cause altered activity of a neuron in the tissue. In certain embodiments, the altered activity causes a change in one or molecules in the tissue or blood.

Abstract: A magnetic healing system uses two like magnets arranged so that a similar pole from each is aligned and thus produces free electrons. The free electrons are able to enter a person's body and neutralize free radicals found there. The aligned magnets are part of the free electron generator and are held in place by a body.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: The present application is directed to devices, assemblies, systems and methods for targeting one or more sites with electromagnetic radiation. The devices, assemblies and systems are operationally configured to transform and convey electromagnetic radiation to one or more targeted sites. The devices, assemblies and systems may also convey one or more fluids or fluid solutions to the one or more targeted sites.

Abstract: Methods and devices are disclosed for non-invasive optogenetic stimulation of autonomic efferent fibers to regulate glucose metabolism in the liver and brown adipose tissue and to treat metabolic disorders.

Abstract: The present disclosure provides a method and a system for treating a tissue using photodynamic therapy (PDT). A photosensitizer is administered to the tissue and one or more optical fibers are placed in the tissue. A treatment light is applied to the tissue by way of the one or more optical fibers. A temperature of the tissue is measured during application of the treatment light, and a fluence rate of the treatment light is modified based on the temperature of the tissue. For example, the fluence rate may be modified to be lower if the temperature of the tissue is higher than a predetermined threshold.

Abstract: There is provided a therapeutic method and system for utilizing full spectrum of natural solar radiations with an optimum balance of ultra-violet (UV), visible and infrared (IR) radiations. The disclosed therapeutic method comprising collecting and concentrating the natural solar radiations using a natural solar radiations concentrator; transporting the concentrated natural solar radiations using a transporting medium to an indoor device; optimizing a spot size, an intensity and an ultra-violet range of the natural solar radiations; and directing the optimized natural solar radiations to a desired body part using the indoor device; wherein the full spectrum of natural solar radiations has an optimum balance of ultra-violet, visible and infrared radiations.

Abstract: The present invention provides a skin care device which performs optical care and thermal care in one device and minimizes noise that may occur in the skin measurement sensor, the device comprising: a housing for forming an outer appearance; a heat transfer bracket disposed at one end of the housing; a light source unit mounted on one end of the housing; a light transfer bracket including a light permeable material and fixed to the housing to cover the light source unit; a skin measurement sensor extending through a first hole formed in the light transfer bracket to protrude outward; and a first substrate mounted with the light source unit and spaced from the skin measurement sensor.

Abstract: A radiation therapy apparatus determines a set of angles that have a tracking quality metric value that satisfies a tracking quality metric criterion. During an alignment phase or a treatment phase for a treatment stage of a target by the radiation therapy apparatus, the radiation therapy apparatus performs selects at least a first angle and a second angle from the set of angles for a first rotation of the gantry. The radiation therapy apparatus generates, using an imaging device mounted to the gantry, a first tracking image of the target from the first angle during the first rotation of the gantry. The radiation therapy apparatus generates, using the imaging device, a second tracking image of the target from the second angle during the first rotation of the gantry. The radiation therapy apparatus performs the target tracking based on the first tracking image and the second tracking image.

Abstract: Carriers for embodying radioactive seeds, as well as a device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present disclosure relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.

Abstract: A radiation medical device, comprising a main support, and a radiation assembly (30) and an imaging assembly (20) respectively located at both ends of the main support. After an imaging scan is completed and pathological tissue positioning pictures are taken, a patient is directly moved to the other end of the main support to allow the radiation assembly (30) to perform radiation therapy to improve the efficiency of the radiation therapy after the completion of pathological tissue positioning, and effectively reduce movement of the patient when the patient is being moved for radiation therapy after the imaging assembly (20) completes pathological tissue positioning, thus reducing pathological tissue positioning error caused by too much movement.

Abstract: An electron accelerator including a resonant cavity, an electron source, an RF system, and at least one magnet unit is provided. The resonant cavity further includes a hollow closed conductor and the electron source is configured to radially inject a beam of electrons into the cavity. The RF system is configured to generate an electric field to accelerate the electrons along radial trajectories. The at least one magnet unit further-includes a deflecting magnet configured to generate a magnetic field that deflects an electron beam emerging out of the resonant cavity along a first radial trajectory and redirects the electron beam into the resonant cavity along a second radial trajectory. The resonant cavity further includes a first half shell, a second half shell, and a central ring element.

Abstract: A system for treating a target volume with ions includes an ion source configured to provide an ion beam for use in scanning the target volume in a first direction and in a second direction; a movable platform for supporting a patient; a motor for moving the platform relative to the ion beam; and at least one processor configured to cause rastering of the target volume by: scanning the ion beam across the target volume in a first direction; and controlling the motor to move a patient on the movable platform in a second direction.

Abstract: Methods are disclosed for replacing expired or unserviceable aircraft emergency slides (“slides”) in an aircraft. The disclosed methods utilize containers that are configured to securely retain both unserviceable slides and serviceable slides at different times in different configurations as installation tools. The container can be placed on an aircraft through the main door of the aircraft, and are further configured to be easily transported within the aircraft from a staging area of the aircraft to a slide installation and removal point at either the main door or an emergency exit door of the aircraft. The containers can be aligned with the installation and removal point to facilitate replacing an unserviceable slide with a new, serviceable slide. The disclosed methods and containers improve personnel safety concerning lifting and handling of the slides, which are heavy.

Abstract: A fall protection device comprises an energy harvester to generate electrical power in response to movement of an elongate member and a circuit powered by the generated electrical power; an impact indicator connected to an elongate member, a controller connected to the elongate member and/or the impact indicator to generate a message in response to impact, and a transmitter connected to the controller to transmit the message; and/or a sensor connected to an elongate member and a controller connected to the sensor to generate a message in response to movement of the elongate member. The fall protection device could include a generator to generate electrical power, an energy storage capacitor to store the generated electrical power, a controller powered by the energy storage capacitor to generate a message in response to action, and a wireless transmitter powered by the energy storage capacitor to transmit the message.

Abstract: This disclosure relates to pelican hooks and related systems. In one embodiment, the pelican hook includes a hook that defines a hook gap, a gate for the hook gap, and a gate mechanism. The gate is configured to be opened so as to open the hook gap and is configured to be closed so as to close the hook gap. The gate mechanism includes a gate actuator for opening the gate and a lock actuator for unlocking the gate. To do this, the gate mechanism is configured such that actuating the lock actuator toward the gate actuator unlocks the gate and such that actuating the gate actuator toward the lock actuator opens the gate. In this manner, the user can operate the pelican hook with a single hand and without having to let go of the pelican hook.

Abstract: A fall restraint for a worker on a roof comprising a yoke line, wherein a first end of the yoke line is releasably connected to a first building structure and a second end of the yoke line is releasably connected to a second building structure. The fall restraint also comprises a support line, wherein a first end of the support line is slidably connected to the yoke line, and a second end of the support line is connected to a worker harness, wherein the support line is adapted to travel over a ridge line of the roof and at least partially support the weight of the worker.

Abstract: A fire protection element includes a mat of intumescent material, a reinforcing liner and ventilation holes. Furthermore, a fire protection wrap is used as a fire protection element of this type.

Abstract: A firefighting aircraft with a body and wings comprises a firing means configured to fire at least one fire suppression container provided in the body. The at least one fire suppression container has a casing filled with a fire extinguishing material and formed of a material destroyed by an impact. The first extinguishing material includes at least one of a fire extinguishing liquid, a fire extinguishing powder, or a fire extinguishing foam.

Abstract: The invention relates to an air-guiding component (1) for a pipe system, in particular for a pipe system for gaseous media preferably used in an aspirating fire detection and/or air-monitoring system. The air-guiding component (1) comprises a housing (7) having a gas inlet (12a) and a gas outlet (12b), wherein the gas inlet (12a) and the gas outlet (12b) are fluidically connected or connectable to the pipe system in order to form a flow path from the gas inlet (12a) to the gas outlet (12b) in the interior of the housing. A connection region with a port (6) is also provided for fluidically connecting, as needed or optionally, the housing interior to a maintenance/cleaning device.

Abstract: Systems and methods for filling and pressurizing a container with liquid suppressant and nitrogen gas. A pressurized receiving container of nitrogen gas is provided at a predetermined gas pressure and liquid suppressant is added to the pressurized receiving container. The predetermined gas pressure provides a sufficient amount of nitrogen to saturate the added liquid suppressant and provide an operative head space pressure within the receiving container without the need for mechanized mixing.

Abstract: A fire apparatus includes a chassis, a body assembly coupled to the chassis, a front cabin coupled to a front end of the chassis forward of the body assembly, a front axle coupled to the front end of the chassis, a rear axle coupled to a rear end of the chassis, and a ladder assembly having a proximal end coupled to the chassis. The body assembly includes one or more angled portions. The one or more angled portions at least partially facilitate the ladder assembly in traveling through at least one of a sweep angle range or a depression angle range.

Abstract: A system for filling a tank for a firefighting helicopter with water without ground personnel, comprising a pilot controlled valve assembly to selectively permit water to flow into the refill tank upon the receipt of a communication transmitted by a communication device within the helicopter. The pilot controlled valve assembly can include a supply valve configured to move between at least a closed state and an open state, a controller configured to control the supply valve, and a receiver configured to send a signal to a controller to cause the controller to at least open the supply valve upon receipt by the receiver of a communication meeting one or more predetermined criteria. The water tank can be filled from a water source, including a municipal water source, when the supply valve is open to provide a more efficient, semi-autonomous refill tank system greatly improves costly and time-consuming manually refill systems.

Abstract: The present invention relates to an automatic fire extinguishing system for small spaces using fire extinguishing agents comprising the automatic fire extinguishing system to be installed in a small space, wherein the moving member is moved by an elastic body installed in the housing when the glass bulb installed in the housing is broken by heat from a fire; the fire extinguishing agents breaks the membrane of the tank storing the pressurized fire extinguishing agents with the striking member connected with the moving member; the striking member connected with the moving member breaks the membrane of the tank which stores pressurized fire extinguishing agents; and the pressurized fire extinguishing agents are spread to the small space, which leads to suppressing the fire at an early stage. When a fire breaks out in a small space susceptible for a fire such as distribution boxes, substation boxes, refrigerators, server racks, etc.