Patents Issued in February 13, 2020
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Publication number: 20200046916Abstract: A refill assembly for use in a medicinal inhaler, the refill assembly being configured to be removably coupled to a reusable assembly of a medicinal inhaler, the refill assembly comprising: a patient port; a canister actuable by the reusable assembly to deliver a dose of medicament to the patient port, a sleeve which is selectively actuable by a user independently of the reusable assembly so as to act on the canister to deliver a dose of medicament, the sleeve having a first position in which the sleeve cannot be actuated to cause a dose of medicament to be released from the canister and a second position in which the sleeve is actuable to cause a dose of medicament to be delivered to the patient port; the refill assembly further comprising: an override element which engages the sleeve, the override element being moveable from a first position in which the sleeve is retained in its first position by the override element and a second position in which the sleeve is permitted to move to its second position uponType: ApplicationFiled: April 25, 2018Publication date: February 13, 2020Inventors: Robert May, David M. Molony, Iain G. McDerment
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Publication number: 20200046917Abstract: A dry powder inhaler including replaceable cartridges containing a dry powder for local or systemic delivery through the pulmonary tract and lungs is disclosed. The inhalers are used with inhalable dry powders, including medicament formulations comprising active agents for local or systemic delivery and for the treatment of diseases such as, pulmonary hypertension, cardiovascular disease, anaphylaxis, diabetes, obesity, cancer, and other diseases, or symptoms associated with these and other diseases, such as nausea, vomiting, pain and inflammation.Type: ApplicationFiled: October 14, 2019Publication date: February 13, 2020Inventors: P. Spencer Kinsey, Brendan Laurenzi, Chad C. Smutney, Benoit Adamo, Joseph Guarneri
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Publication number: 20200046918Abstract: There is disclosed a device for delivering a fluid spray to a mouth of a user, either directly, or via a flow conductor such as a tube or pipe. The spray device uses a vibrating perforate membrane to create the spray and the vibration of the membrane is controlled in response to input from a flow rate sensor which detects a flow rate through the device or through the flow conductor. There is further disclosed a corresponding method of controlling a spray head in a spray delivery device.Type: ApplicationFiled: June 10, 2016Publication date: February 13, 2020Inventor: Robert Gordon Maurice Selby
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Publication number: 20200046919Abstract: Devices and methods for nasal administration of a pharmaceutical composition. In certain embodiments, the devices comprises a reservoir, a conduit in fluid communication with the reservoir, and an anatomic positioning device configured to position the conduit in a nasal cavity of a user. Particular embodiments include an actuator configured to transfer the pharmaceutical composition from the reservoir to the conduit and emit the pharmaceutical composition from the conduit.Type: ApplicationFiled: October 3, 2017Publication date: February 13, 2020Inventors: Hugh D.C. SMYTH, Robert O. WILLIAMS, III, Zachary WARNKEN, Yang LU
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Publication number: 20200046920Abstract: A method and apparatus for breathing including a blower mounted in a specific part made of silicone, which reduces blower immissions and emissions. The conducting structure influences the flow of the respiratory gas in order to reduce interference when measuring the volumetric flow.Type: ApplicationFiled: February 16, 2018Publication date: February 13, 2020Inventors: Marcus DIEHL, Stefan HEIN, Matthias PULLA, Frank HERRMANN
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Publication number: 20200046921Abstract: A method for controlling operation of a CPAP apparatus. The apparatus has a blower, a patient interface, an air delivery conduit for delivering air from the blower to the patient interface, a sensor for determining the pressure in the patient interface, and a control mechanism that causes air to be delivered at a desired pressure to the patient interface and that detects transitions between inhalation and exhalation of a respiratory cycle of a patient in order to synchronise the blower output with the patient's efforts. In one form the CPAP apparatus provides pressure in accordance with a bi-level waveform with at least one characterising parameter of the waveform being automatically adjusted in accordance with indications of sleep disordered breathing. The indications of sleep disordered breathing can be one or more of snoring, apnea, hypopnea, and flow limitation.Type: ApplicationFiled: July 23, 2019Publication date: February 13, 2020Applicant: ResMed Pty LtdInventors: Robert DOUGLAS, Anthony John UJHAZY, Glenn RICHARDS, Mark David BUCKLEY, Klaus Henry SCHINDHELM
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Publication number: 20200046922Abstract: A manual ventilation feedback sensor for use in clinical and training settings is disclosed. Namely, a manual resuscitator device is disclosed that comprises a bag valve mask, a one-way valve, a manual ventilation bag, and a sensing module, wherein the sensing module can comprise a pressure sensor and/or flow transducer. Sensing module may further comprise a controller for processing information from the pressure sensor and/or flow transducer; namely for determining and indicating a ventilation rate. Indicators are provided to guide the user with respect to a target or desired ventilation rate.Type: ApplicationFiled: October 22, 2019Publication date: February 13, 2020Inventors: Jordan Duval-Arnould, Julie Campbell, Elizabeth Hunt
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Publication number: 20200046923Abstract: Various embodiments are described herein for devices, methods and systems for a breathing assistance device controller for controlling the operation of a breathing assistance device that provides breathing assistance to a user. The controller may include sensors for measuring airflow parameters of the airflow and generating measured signals; and a processor that is electronically coupled to the sensors to receive the measured signals and to generate a control signal based on the measured signals and at least one characteristic of the user's respiratory system to adjust the operation of the breathing assistance device during use.Type: ApplicationFiled: October 20, 2017Publication date: February 13, 2020Inventor: Hamed Hanafialamdari
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Publication number: 20200046924Abstract: A ventilator system (10) includes a ventilator source (12), camera (14), database (16) and controller (16). A first plurality of ventilation components in a ventilation circuit (34) are coupled between the ventilator source and a patient. The camera captures images of the ventilation circuit. The database includes multi-view images of a second plurality of ventilation components pre-approved for use with the ventilator source. The controller (16) includes (i) a control module (22), (ii) a component recognition and identification module (24), (iii) a component tracking module (26) configured to track targets and to detect at least one change in tracked targets, and (iv) a ventilation compensation module (28).Type: ApplicationFiled: November 1, 2017Publication date: February 13, 2020Inventor: WILLIAM ANTHONY TRUSCHEL
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Publication number: 20200046925Abstract: A method for the concurrent treatment of obstructive sleep apnea and hypertension in a patient comprises providing a flow of treatment gas to the airway of the patient in accordance with a first set of flow parameters. Determining that the patient has achieved stable breathing while receiving the provided flow of treatment gas in accordance with the first set of parameters. Determining a set of target patient breath parameters from breath data collected from the patient. Adjusting the flow of treatment gas to a different set of flow parameters. Determining that the new patient breath data, collected from the patient, accords with the target patient breath parameters and providing the flow of treatment gas to the patient in accordance with the different set of flow parameters. The target patient breath parameters include a target tidal volume of the patient which is greater than a first tidal volume of the patient.Type: ApplicationFiled: March 23, 2018Publication date: February 13, 2020Inventors: JONATHAN SAYER GRASHOW, GREGORY DELANO MATTHEWS, MICHAEL THOMAS KANE, EUGENE NELSON SCARBERRY
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Publication number: 20200046926Abstract: An artificial airway device 1 to facilitate lung ventilation of a patient, comprising an airway tube 2 including a lumen 3, a mask 4 at one end of the airway tube, the mask including a backplate 5 and having a peripheral formation 6 capable of forming a seal around the circumference of the laryngeal inlet, the peripheral formation surrounding a hollow interior space or lumen 7 of the mask and the airway tube 2 opening into the lumen of the mask 4, and a connector 8 disposed at the proximal end of the airway tube, the connector including a main bore 9 for passage of gas to the airway tube lumen 3, and a wall 10 defining a circumference and including a plurality of ports 12 to allow passage of gas to the main bore, at least one port 12 being disposed for circumferential rotational movement relative to the main bore 9.Type: ApplicationFiled: October 20, 2017Publication date: February 13, 2020Applicant: Teleflex Life Sciences Unlimited CompanyInventor: Kien Chung Kwok
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Publication number: 20200046927Abstract: Breathing disorders such as snoring and sleep apnea are common disorders disrupting an individual's normal breathing. Improper or obstructed breathing can affect a person's health and wellbeing. This application describes a breathing assistance apparatus and related methods for opening a person's nasal passage to aide in breathing and treat common breathing disorders.Type: ApplicationFiled: August 7, 2018Publication date: February 13, 2020Inventor: Joseph Batrice
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Publication number: 20200046928Abstract: A patient interface has a single loop headstrap and a mask for covering at least the nostrils of the user. The single loop headstrap extends from the mask at either end. A short length of supple conduit is coupled to the mask by a swivel or ball joint to allow rotation of the conduit relative to the mask through different angles and orientations.Type: ApplicationFiled: March 19, 2019Publication date: February 13, 2020Inventors: Olivia Marie Allan, Arvin San Jose Gardiola, Lewis George Gradon, Wen Dong Huang, Alastair Edwin McAuley, Mark Arvind McLaren, Craig Robert Prentice, Andrew Paul Maxwell Salmon, Silas Sao Jin Siew
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Publication number: 20200046929Abstract: The present disclosure relates to a comfortable and adjustable nasal pillow configured to be part of a nasal pillow system that is part of a mask system used with a ventilation or PAP device. The nasal pillows are configured to have multiple degrees of freedom of rotation.Type: ApplicationFiled: October 19, 2019Publication date: February 13, 2020Applicant: BREAS MEDICAL, INC.Inventors: Donald Harrison, Andrew Havens Gosline, Veaceslav Gheorghe Arabagi, Aaron Jonah Kapelus
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Publication number: 20200046930Abstract: A respiratory mask assembly for delivering breathable gas to a patient includes a frame having a front surface and a rear surface adapted in use to face the patient. The frame includes a main body providing an aperture therethrough for the introduction of breathable gas into a nasal breathing cavity. An elbow assembly is swivelably coupled to the front surface of the frame. The elbow assembly includes a swivel elbow that defines an intake port and an exhaust port separated from the intake port using a baffle. The elbow assembly includes an end portion that interfaces with the aperture of the frame.Type: ApplicationFiled: October 23, 2019Publication date: February 13, 2020Inventors: Anthony Michael GING, Saad NASR, Rachael Elizabeth MOORE, Andrew Martin PRICE
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Publication number: 20200046931Abstract: A humidifier includes a tub configured to hold a supply of water. The tub includes a tub lid and a tub base adapted to be coupled to the tub lid. The tub further includes a base plate formed of a heat conducting material and adapted to be coupled to the tub base and a seal positioned between the base plate and the tub base. The tub also includes a retaining mechanism with at least one projection that projects from the tub base and is configured to force the base plate against the seal so that the seal is secured against the tub base.Type: ApplicationFiled: October 18, 2019Publication date: February 13, 2020Inventors: John Michael SNOW, Simon Robert CORK, John ZEKIC, Benjamin John HUNTER
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Publication number: 20200046932Abstract: Methods and systems are provided for humidification of gas streams, such as air or oxygen. Hydrated superabsorbent polymers are used to provide humidity to flowing gas streams. Humidified gas streams may be used in respiratory therapy and other applications for which humidified air is desired and/or beneficial.Type: ApplicationFiled: October 22, 2019Publication date: February 13, 2020Inventors: Dean R. Cortese, William E. Beecher, Jr.
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Publication number: 20200046933Abstract: A valve arrangement (60) is for a patient interface device (10) having a frame portion (16). The valve arrangement includes a valve member (36) having a coupling portion (44) and a blocking portion (46) extending from the coupling portion. The coupling portion of the valve member is structured to be coupled to the frame portion. The blocking portion is structured to move between a first position and a second position. The valve arrangement further includes a guard member (40) having a coupling portion (48) and a protecting portion (50) extending from the coupling portion of the guard member. The coupling portion of the guard member is structured to be coupled to the frame portion. When the blocking portion of the valve member moves from the first position toward the second position, the blocking portion moves toward the protecting portion of the guard member.Type: ApplicationFiled: March 20, 2018Publication date: February 13, 2020Inventors: KEVIN DANIEL HIMES, DERRICK BLAKE ANDREWS, ROBERT EARL HIEBER
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Publication number: 20200046934Abstract: An apparatus for stimulating neurons that includes a stimulation unit for applying pulse-like tones, a measuring unit for picking up measurement signals that render neural activity by the stimulated neurons, a control. The control unit applies a first pulse train having varied pitch, takes the measurement signals picked up in response to the first pulse train to select a first pitch range or pitch in which there is phase synchronization between the pulse train and the neural activity, actuates the stimulation unit to apply two phase-shifted second pulse trains, the pitch of the pulse trains being varied in opposite directions and a pitch starting value of the second pulse trains based on first pitch range or pitch that is used to select a second pitch range or pitch resulting in minimum amplitude of the neural activity.Type: ApplicationFiled: June 21, 2019Publication date: February 13, 2020Inventor: Peter Alexander Tass
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Publication number: 20200046935Abstract: A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.Type: ApplicationFiled: August 20, 2019Publication date: February 13, 2020Applicant: Yeda Research and Development Co. Ltd.Inventors: Anat ARZI, Lee SELA, Anton PLOTKIN, Aharon WEISSBROD, Noam SOBEL
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Publication number: 20200046936Abstract: Methods, systems and devices for reducing anxiety, including increasing relaxation and/or calm. In some variations these methods may include reducing anxiety, increase relaxation and/or calm by non-invasive temperature regulation of the frontal cortex prior to and/or during sleep. The subject may have an anxiety disorder, or may not have a diagnosed anxiety disorder.Type: ApplicationFiled: October 22, 2019Publication date: February 13, 2020Inventors: Eric A. NOFZINGER, Jeffrey J. SCHIRM
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Publication number: 20200046937Abstract: A catheter according to an embodiment of the present disclosure includes a mesh member, a first hollow shaft, a front end tip, a guiding film, a second hollow shaft, a core wire, and a holding member. The mesh member has a tubular shape and is radially expandable and contractable. The guiding film is disposed on the mesh member and has a front end located between a base end of the front end tip and a front end of the first hollow shaft. The second hollow shaft is connected to the front end tip and disposed so as to protrude in a space inside the mesh member toward a base end side. The holding member has a substantially ring-like shape or a substantially C-like shape in a cross-sectional view, and is provided at the core wire so as to cover the second hollow shaft.Type: ApplicationFiled: October 21, 2019Publication date: February 13, 2020Applicant: ASAHI INTECC CO., LTD.Inventors: Yuta NAKAGAWA, Toshihiko TSUKAMOTO, Tomoya SAWATA
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Publication number: 20200046938Abstract: A catheter assembly may include a catheter adapter, which may include a distal end, a proximal end, and a lumen extending therethrough. The catheter assembly may also include a septum slidably disposed within the lumen. The septum may include a distal end, a proximal end, and a barrier disposed between the distal end of the septum and the proximal end of the septum. The barrier may divide an interior of the septum into a distal cavity and a proximal cavity. A distal face of the barrier may include a protrusion. The barrier may include a slit extending through the protrusion for selectively opening fluid communication between the distal cavity and the proximal cavity.Type: ApplicationFiled: July 18, 2019Publication date: February 13, 2020Inventor: Yiping Ma
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Publication number: 20200046939Abstract: An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter having a flexible, distal luminal portion having an inner diameter defining a lumen extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator having a flexible, distal dilator portion sized to be received within the lumen of the luminal portion. Associated systems, devices, and methods of use are also described.Type: ApplicationFiled: October 8, 2019Publication date: February 13, 2020Inventors: Michi E. Garrison, Tony M. Chou, Scott D. Wilson
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Publication number: 20200046940Abstract: An intravascular access system for facilitation of intraluminal medical procedures within the neurovasculature through an access sheath. The system includes an aspiration or support catheter having a flexible, distal luminal portion having an inner diameter defining a lumen extending between a proximal opening at a proximal end of the luminal portion and a distal opening at a distal end of the luminal portion. The catheter has a rigid spine coupled to at least the proximal end of the luminal portion and extending proximally therefrom. The system includes a dilator having a flexible, distal dilator portion sized to be received within the lumen of the luminal portion. Associated systems, devices, and methods of use are also described.Type: ApplicationFiled: October 8, 2019Publication date: February 13, 2020Inventors: Michi E. Garrison, Tony M. Chou, Scott D. Wilson
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Publication number: 20200046941Abstract: A locking mechanism for a medical device to selective lock a first elongate member from longitudinal movement relative to a second elongate member of the medical device. The locking mechanism includes a flexible tubular member disposed in a bore of a handle assembly of the medical device, and an actuator, such as a cam member having a cam or eccentric surface. Pivotable movement of the actuator from a first position to a second position compresses or deforms the flexible tubular member against the first elongate member to lock the first elongate member from longitudinal movement relative to the handle assembly.Type: ApplicationFiled: October 16, 2019Publication date: February 13, 2020Inventors: Jacob Graham, Stephen Derosier, Jeffrey Bean, John Golden
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Publication number: 20200046942Abstract: An instrument having a flexible and elongated body includes at least a lumen and a flex member disposed within the lumen. The flex member may be capable of providing steering control to a first portion of the elongate body while providing load bearing support to a second portion of the elongate body. A pull wire may be disposed within the flex member, and at least a distal portion of the pull wire may be coupled to the elongate body and a proximal portion of the pull wire may be operatively coupled to a control unit. The control unit may be coupled to a proximal portion of the elongate body. In addition, a control member may be operatively coupled to the control unit such that a distal portion of the control member may be positioned near a proximal portion of the flex member. The control member may be configured to support the flex member and control the movement or displacement of the flex member.Type: ApplicationFiled: June 19, 2019Publication date: February 13, 2020Inventors: Jeffery B. Alvarez, Enrique Romo, Francis Macnamara
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Publication number: 20200046943Abstract: The present invention relates to a computer-vision based autonomous steerable catheter device and methods of using the same for targeted delivery of a liquid microvolume into the interior of a lung.Type: ApplicationFiled: August 21, 2019Publication date: February 13, 2020Inventors: Gordana Vunjak-Novakovic, Jinho Kim, John O'Neill, Matthew Bacchetta
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Publication number: 20200046944Abstract: A catheter has a guide-tip including at least one wing for crossing a CTO lesion in an artery via exploring the subintimal space. The catheter can includes one or more exit port(s) and radiopaque marker(s) for steering a re-entry wire through one of the exit ports. The catheter may include a number of spiral-cut sections with varying characteristics to provide different strength and flexibility along the axial direction.Type: ApplicationFiled: October 7, 2019Publication date: February 13, 2020Inventor: Robert J. COTTONE
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Publication number: 20200046945Abstract: A locking line tag is provided that includes an elongated sheet of material having a top, bottom, and opposing lateral sides between the top and bottom, the sheet further having a plurality of scored lines therein that when folded form a tubular structure with a panel at each of the top and bottom ends that interlock with each other and at least a pair of intermediate sections, each of the intermediate sections having a key slot therein that open to opposing lateral sides of the locking tag.Type: ApplicationFiled: July 26, 2019Publication date: February 13, 2020Inventors: Elmer Vera, Cristopher Vera
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Publication number: 20200046946Abstract: A catheter assembly (10) comprises a catheter (20), a needle (22) having a sharp distal tip and disposed within the catheter (20), a catheter hub (30) connected to the catheter (20) having the needle (22) passing therethrough, and a housing (70) that encloses the sharp distal tip of the needle (22). An external surface of the catheter hub (30) and an internal surface of the housing (70) each include at least one of a channel member (34) and a raised portion (72) that interfit to restrict motion between the catheter hub (30) and the housing (70).Type: ApplicationFiled: February 24, 2017Publication date: February 13, 2020Applicant: Becton, Dickinson and CompanyInventors: Shaun Staley, Weston Harding
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Publication number: 20200046947Abstract: An air removal mechanism includes a body having a hollow portion capable of storing a liquid. In a state where the body is mounted on an introducer sheath, a medical device to be inserted into the introducer sheath is insertable via the hollow portion. The body has an injection path which communicates with the hollow portion and on which an outlet is open toward a valve body.Type: ApplicationFiled: October 18, 2019Publication date: February 13, 2020Applicant: TERUMO KABUSHIKI KAISHAInventors: Takayuki MORI, Kinya HARADA, Wataru KARINO, Katsuhiko SHIMIZU, Youichirou KUWANO
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Publication number: 20200046948Abstract: A method may include priming a catheter system. The catheter system may include a catheter adapter, a catheter, and an extension tube. The catheter system may also include a Y-adapter, which may include first and second arms. A distal end of the Y-adapter may be coupled to the extension tube. The catheter system may further include a vent cap, which may be coupled to the second arm. Priming the catheter system may include attaching an IV line to the first arm and delivering saline through the IV line to the catheter system such that the saline exits a distal tip of the catheter and clamping the IV line via a roller clamp on the IV line. The method may also include actuating the vent cap after priming the catheter system. The method may further include inserting the catheter into a vein of a patient after actuating the vent cap.Type: ApplicationFiled: July 22, 2019Publication date: February 13, 2020Inventors: Jonathan Karl Burkholz, Bin Wang
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Publication number: 20200046949Abstract: A dynamic balloon angioplasty system for applying a dynamic pressure to fracture hardened materials embedded within an elastic conduit. The system having a pressure source system outputting at least a first predetermined pressure from a pressure source outlet, and an angioplasty unit fluidly coupled to the pressure source outlet receiving at least the first predetermined pressure. The angioplasty unit having an angioplasty inflation device, an angioplasty balloon connector, and an oscillating mechanism selectively actuated to output a plurality of pressure pulses to the angioplasty balloon via a fluid communication path. A control system is configured to determine an optimal hydraulic pressure oscillation frequency and amplitude for a given procedure and output a control signal to the oscillating mechanism, and monitor a pressure signal to detect fracture of the hardened material within the elastic conduit or system failure or leakage.Type: ApplicationFiled: October 16, 2019Publication date: February 13, 2020Inventors: Robert CHISENA, Hitinder S. GURM, Matthew HILDNER, Yihao ZHENG, Albert SHIH
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Publication number: 20200046950Abstract: A stent has a center length section, two end sections, and an elastically deformable woven wire mesh, which enables the stent to expand from a small diameter to a larger diameter, with the diameter of the end sections being larger than in the center length section in the expanded state. The wire extends in a zig-zag manner from an outer end of one end section toward the outer end of the other end section, and back in a zig-zag manner to the one end section. The peripheral direction of the woven wire changes at the transition from an end section to the center length section, such that the wire intersects on the return path to the one end section in the center length section and overall forms an 8-shaped loop having two closed eyes, wherein a plurality of interconnected loops are arranged offset to each other over the circumference.Type: ApplicationFiled: July 25, 2018Publication date: February 13, 2020Applicant: NOVATECH SAInventors: Georg Siegner, Peter Ksoll
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Publication number: 20200046951Abstract: The present disclosure provides a fluidic device including (a) a first channel including a first inlet and a first outlet, (b) a second channel including a second inlet and a second outlet, wherein the second inlet of the second channel is in fluid communication with the first outlet of the first channel, and (c) a sensor positioned between the first outlet and the second inlet, wherein the sensor includes a sensor configured to deflect in response to a flow between the first channel and the second channel.Type: ApplicationFiled: March 29, 2018Publication date: February 13, 2020Inventors: Kazunori HOSHINO, Davina JAISWAL, Mengdi BAO, Garrett SOLER, Ariane GARRETT, Ryan GRANT, Michael DILUNA, Hitten ZAVERI
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Publication number: 20200046952Abstract: Systems, catheters, and methods for accessing and treating along the central nervous system are disclosed. An example method may manage inflammation of the patient to treat a condition of the patient by processing values related to one or more physiological parameters of a patent, identifying when an inflammation condition of the patient has reached a treatment condition based on the processed values, and automatically providing an indication that the inflammation condition has reached the treatment condition. An example indication may include actuation of a treatment protocol. The example method may be performed with an inflammation management system.Type: ApplicationFiled: August 8, 2019Publication date: February 13, 2020Applicant: MINNETRONIX NEURO, INC.Inventor: ABHI VASE
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Publication number: 20200046953Abstract: Systems, catheters, and methods for accessing and treating along the central nervous system are disclosed. An example method may manage inflammation of the patient to treat a condition of the patient by processing values related to one or more physiological parameters of a patent, identifying when an inflammation condition of the patient has reached a treatment condition based on the processed values, and automatically providing an indication that the inflammation condition has reached the treatment condition. An example indication may include actuation of a treatment protocol. The example method may be performed with an inflammation management system.Type: ApplicationFiled: August 8, 2019Publication date: February 13, 2020Applicant: MINNETRONIX NEURO, INC.Inventor: ABHI VASE
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Publication number: 20200046954Abstract: The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF) by removing target compounds from CSF. The systems provide for a catheter flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents.Type: ApplicationFiled: August 22, 2019Publication date: February 13, 2020Applicant: NEUROFLUIDICS, INC.Inventors: SHIVANAND LAD, WILLIAM C. MOBLEY, KAROLY NIKOLICH, THOMAS SAUL
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Publication number: 20200046955Abstract: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.Type: ApplicationFiled: October 22, 2019Publication date: February 13, 2020Inventors: Mark E. Deem, Hanson Gifford
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Publication number: 20200046956Abstract: A system for treatment of a wound area of a patient including a first treatment pad comprising a plurality of Light Emitting Diodes (LEDs) for cleaning and exposing a wound area to ultraviolet light, a second treatment pad comprising removal ports for exposing the wound area to a negative pressure, and a control unit interoperably connected to the first and second treatment pads for providing a negative pressure and the ultraviolet light to the wound area.Type: ApplicationFiled: October 22, 2019Publication date: February 13, 2020Applicant: ThermoTek, Inc.Inventors: Overton L. Parish, Niran Balachandran, Tony Quisenberry
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Publication number: 20200046957Abstract: The purpose of the present invention is to provide a microneedle array and a microneedle manufacturing method, which improves medical solution delivery efficiency and facilitates manufacturing. The microneedle array is provided with a first divisional element, a second divisional element to be bonded to the first divisional element, a longitudinal passage formed between the first divisional element and the second divisional element bonded to each other; and a horizontal hole, having an orifice on a lateral side and formed in a direction parallel to a bonding surface of the first divisional element with the second divisional element, and communicating to the longitudinal passage.Type: ApplicationFiled: March 29, 2018Publication date: February 13, 2020Inventors: Noriyuki OGAI, Masahiro TAKIGAWA
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Publication number: 20200046958Abstract: Various embodiments provide an apparatus, system method for treating neurological conditions by delivering solid form medication to the ventricles or other areas of the brain. Particular embodiments provide an apparatus and method for treating epilepsy and other neurological conditions by delivering solid form medication to ventricles in the brain wherein the medication is contained in a diffusion chamber so as to allow the medication to dissolve in the cerebrospinal fluid of the brain and then diffuse out of the diffusion chamber to be delivered to the ventricles and brain tissue. In one or more embodiments, portions of apparatus have sufficient flexibility to conform to the shape of the ventricles of the brain when advanced into them and/or to not cause deformation of the ventricle sufficient to cause a significant physiologic effect.Type: ApplicationFiled: August 7, 2019Publication date: February 13, 2020Inventors: Mir Imran, Phillip Morgan, Ben Tranchina, Paul Spehr, Kyle Horlen
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Publication number: 20200046959Abstract: A medical connector including a first rigid body capable of being connected to a medical infusion line and having an elongated tubular element in which there is a conduit opening out at opposite extremities, a first extremity of the tubular element being capable of being directly connected to the medical infusion line, the elongated tubular element being capable of being closed off at one of its first open extremities by a second body associated with the first body. The second body is of yielding material and at least partly covers the elongated element and extends beyond the second extremity of that element in such a way as to close off the opening thereof, such second body being overmoulded onto the first body and forming a single piece therewith.Type: ApplicationFiled: October 21, 2019Publication date: February 13, 2020Applicant: GVS S.P.A.Inventors: Joao BAJAC, Carlos Henrique ALVAREZ
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Publication number: 20200046960Abstract: Disinfection cap includes housing comprising closed top, essentially cylindrical sidewall, and open bottom formed by the sidewall with opening to inner cavity within the housing for receiving mating feature of needleless connector. Disinfection sponge can be configured within inner cavity, with removable cover sealing opening to inner cavity to seal sponge within inner cavity prior to cap use. Inner cavity includes threads on inner surface of its sidewall that do not correspond to the mating feature of needleless connector. One thread engages with mating feature of needleless connector. Plurality of disinfection caps can be disposed on strip of IV pole hanging device such that each cap can be peeled off the strip unsealed for immediate use, or separated from the strip sealed for later use.Type: ApplicationFiled: August 21, 2019Publication date: February 13, 2020Applicant: Becton, Dickinson and CompanyInventors: Kevin M. RYAN, Nichola CHARLES
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Publication number: 20200046961Abstract: A check valve for use in a fluid pathway. The check valve may have a diaphragm and a plurality of supports extending from the diaphragm. The check valve and supports have a line of symmetry, and deformation of the check valve as it moves from a closed position to an opened position can be generally along the line of symmetry.Type: ApplicationFiled: June 21, 2019Publication date: February 13, 2020Inventor: David Nelson
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Publication number: 20200046962Abstract: A wearable cardioverter defibrillator (WCD) comprises a plurality of electrocardiography (ECG) electrodes, a right-leg drive (RLD) electrode, and a plurality of defibrillator electrodes to contact the patient's skin when the WCD is delivering therapy to the patient, a preamplifier coupled to the ECG electrodes and the RLD electrode to obtain ECG data from the patient as one or more ECG vectors, a high voltage subsystem to provide a defibrillation voltage to the patient through the plurality of defibrillator electrodes, and an impedance measurement circuit to measure an impedance across a first pair of ECG electrodes, wherein the impedance measurement circuit is to apply a balancing impedance across a second pair of ECG electrodes when an impedance of the second pair of ECG electrodes is not being measured.Type: ApplicationFiled: August 12, 2019Publication date: February 13, 2020Inventors: Zhong Qun Lu, Douglas K. Medema, Kenneth F. Cowan
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Publication number: 20200046963Abstract: The invention relates to a transdermal therapeutic system (TTS) for delivering pharmaceutical active ingredients. The TTS includes a cover layer and at least one active-ingredient-containing carrier material. At least one retaining element is located between the active-ingredient-containing carrier material and the cover layer, with the retaining element fixing the active-ingredient-containing carrier material onto the cover layer. The invention further relates to a method for fastening an active-ingredient-containing carrier material to a cover layer of a TTS in the presence of hook-and-loop strip segments and the use of a hook-and-loop strip in transdermal or iontophoretic administration of pharmaceutical or therapeutic active ingredients to patients.Type: ApplicationFiled: October 18, 2019Publication date: February 13, 2020Inventors: Mohammad SAMETI, Ronald HACKBARTH, Klaus SCHUMANN, Christoph SCHMITZ
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Publication number: 20200046964Abstract: An apparatus includes a controllable signal source and a processor. The controllable signal source is configured to apply an Alternating Current (AC) signal to multiple electrodes of a multi-electrode catheter immersed in an aquatic solution. The processor is configured to, responsively to the applied AC signal, estimate a respective surface impedance or a respective electrical noise level of each of the electrodes. The processor is further configured to disconnect each electrode, independently of other electrodes, when the estimated surface impedance or electrical noise level of the electrode drops below a preset value.Type: ApplicationFiled: August 13, 2018Publication date: February 13, 2020Inventors: Eyal Rotman, Michael Levin, Yevgeny Bonyak, Alek Vilensky, Meir Bar-Tal, Oleg Dulger
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Publication number: 20200046965Abstract: The present invention relates to a method for positioning a tip of a pacemaker lead that has passed through coronary sinus into an interventricular septum. More particularly, it relates to a method for positioning a tip of a pacemaker lead that has passed through a coronary sinus into an interventricular septum in order to more effectively transmit an electrical stimulus in a treatment using a pacemaker for patients with arrhythmia. A method of positioning a tip of a pacemaker lead, which has passed through a coronary sinus, into an interventricular septum, in order to effectively transmit electrical stimulus, includes: inserting into an intervention wire through a superior vena cava and a coronary sinus to pass through the interventricular septum and then guiding the intervention wire to an inferior vena cava; and positioning the tip of the lead into the interventricular septum by inserting the pacemaker lead along the intervention wire.Type: ApplicationFiled: May 10, 2019Publication date: February 13, 2020Applicant: TAU PNU MEDICAL CO., LTD.Inventor: June-hong KIM