Abstract: There is provided an implant that is safe for the living body. An angular plate as the implant includes a bone supporting plate part and a blade part. The blade part is integrally formed with the bone supporting plate part, and extends from one end of the bone supporting plate part at a predetermined angle ? (0°<?<180°) relative to the bone supporting plate part. The angular plate is formed from a titanium-tantalum-based alloy containing tin. The angular plate is preferably formed from a titanium-tantalum-based alloy containing tin in which a Young's modulus is decreased by increasing the reduction ratio thereof.

Abstract: An injectable composition having dermal filling and tissue expanding activity comprises: (1) a quantity of elastin sufficient to bring about dermal filling and tissue expansion when injected into a subject in need of dermal filling and tissue expansion; and (2) a pharmaceutically acceptable carrier. The composition can further comprise collagen; in other alternatives, the composition can further comprise hyaluronic acid; and one or more of the elastin, the collagen, and the hyaluronic acid, if present can be cross-linked, either intramolecularly or intermolecularly. The elastin, however, is the primary filler, even if collagen or hyaluronic acid are included in the composition.

Abstract: A multilayer bioabsorbable construct is provided that includes at least one top layer, at least one chorion membrane layer, at least one basement layer, and at least one support layer between the chorion membrane layer and basement layer. Various therapeutic uses of the multilayer bioabsorbable construct are also provided.

Abstract: A biocompatible, bioresorbable tissue repair implant or scaffold device is provided for use in repairing a variety of cartilage tissue injuries, and particularly for resurfacing and/or repairing damaged or diseased cartilage. The repair procedures may be conducted with tissue repair implants that contain a biological component that assists in delaying or arresting the progression of degenerative joint diseases and in enhancing tissue healing or repair. The biocompatible, bioresorbable tissue repair implants include a scaffold and particles of viable tissue derived from cartilage tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.

Abstract: A method of corneal implantation with cross-linking is disclosed herein. In one or more embodiments, the method includes the steps of: (i) cutting a circular implant from a donor cornea; (ii) cutting the circular implant into a plurality of constituent pieces; (iii) forming a small incision in a recipient cornea of an eye of a patient; (iv) forming a pocket in the recipient cornea of the eye of the patient, the pocket being accessible through the small incision in the recipient cornea, and the pocket being bounded entirely by stromal tissue of the cornea; and (v) inserting each of the plurality of constituent pieces of the implant into the pocket of the recipient cornea via the small incision, wherein the implant is cross-linked so as to prevent an immune response to the implant and/or rejection of the implant by the patient.

Abstract: The present invention concerns composite biomaterials comprising ceramic and a biodegradable polymer gel, with improved bioactivity, their process of preparation and their use for orthopedics, dentistry or reconstructive surgery, in particular for use as a bone filler.

Abstract: The present invention relates to orthopedic implants, in particular to hip and knee prostheses, substantially involving metallic substrates with an antibacterial surface treatment consisting of silver immobilized in an organic linker and ligand via a multistep solution dipping and drying process. This treatment while being biocompatible is designed to inhibit bacterial growth and therefore combat periprosthetic infection which is one of the main causes of revision in hip and knee arthroplasty.

Abstract: An implant comprising at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered “the hydrogel”), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.

Abstract: The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.

Abstract: The present disclosure relates to a catheter lock solution which instills into the lumen of the catheter and helps to maintain catheter patency when the catheter is not used for treatment of a patient. In particular, the present invention and its embodiments relate to a use of sodium bicarbonate solution as a catheter lock solution.

Abstract: A fluid level sensor assembly for monitoring a fluid level in a fluid collection canister of a medical waste fluid collection system. The fluid level sensor assembly includes a fluid level sensor configured for monitoring the fluid level in the fluid collection canister and a fluid level sensor cover configured for preventing direct contact between the fluid level sensor and a fluid in the fluid collection canister. The fluid level sensor cover includes a polymeric cap and polymeric sheath extending from the cap. The elongate tubular sheath surrounds an elongate probe of the sensor with the cap positioned at a base of a sensor body of the sensor to prevent direct fluid contact with the elongate sensor probe and the sensor body.

Abstract: Some embodiments of a multi-layered dressing system for sealed wound treatment include various components used for sealing, dressing, suctioning and irrigating that are coupled together as a single, composite unit.

Abstract: A negative pressure device includes a drape, a wicking element, a sealing element, a reactor, a chamber and an air permeable liquid impervious element. The drape includes an opening and is made from a flexible material that inhibits passage of liquid and air through the drape other than through the opening. The wicking element is covered by the drape. The sealing element surrounds the wicking element and cooperates with the drape to define an enclosed volume covered by the drape and surrounded by the sealing element. The reactor is configured to react with a gas found in air to consume the gas. The chamber is in fluid communication with the reactor and the enclosed volume via the opening. The chamber is configured to maintain a predefined chamber volume while the gas is being consumed from the enclosed volume.

Abstract: A vented chest wound seal for a penetrating chest wound including a flexible sheet including a bottom surface, and an adhesive layer covering a portion of the bottom surface of the flexible sheet, the adhesive layer including an inner perimeter and an outer perimeter, the inner perimeter defining a chamber, wherein the chamber includes a vent channel extending radially outward from a central portion of the chamber, wherein the flexible sheet includes a vent hole aligned over the vent channel, and wherein the inner perimeter and the outer perimeter are separated by a minimum hydrogel width.

Abstract: Apparatus and methods are described including a catheter (20), a first pump (24U) disposed on the catheter, and a second pump (24D) disposed on the catheter, proximally to the first pump. A control unit (52) is configured to control activation of the first and second pumps. The first and second pumps are configured, when activated, to pump fluid in opposite directions from one another. Other applications are also described.

Abstract: A catheter pump assembly is provided that includes an elongate body, an elongate flexible shaft disposed in the elongate body, and an impeller coupled with the distal end of the elongate flexible shaft. The drive system includes a drive component, a motor and a tension member. The tension member is coupled with the motor and the drive component and to cause the drive component to rotate, and thereby to cause the impeller to rotate.

Abstract: A mechanism for adjusting occlusion of a roller pump is described, wherein the mechanism is provided with: an elongated rod member oriented on a central axis of a pump head of the roller pump; and a drive member attached to the elongated rod member so as to move along the elongated rod member between a first position and a second position, wherein the drive member is connected to each roller block of a pump rotor of the pump head so that movement of the drive member by constant increments along the elongated rod member causes non-uniform and/or non-linear incremental movement of each roller block in a direction radial to the central axis of the pump head.

Abstract: An implantable heart help device adapted for implantation in a human patient is provided. The device comprising a fixating member adapted to fixate said device to a part of the human body comprising bone. Further a method of fixating an implantable heart help device in a human patient is provided. The method comprises the steps of: cutting the skin of said human patient, dissecting an area of the body comprising bone, and fixating said implantable heart help device to said part of the body comprising bone.

Abstract: Systems and methods of generating a customized dialysate solution are provided. The system and methods use stock concentrates, with the addition of spikes to generate a customized dialysate solution based on the needs of the patient.

Abstract: A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in fluid communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood in a blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.

Abstract: A system and method for draining excessive fluid from a body cavity or space. The system comprises an implantable fluid penetrable chamber comprising a frame covered by a fluid permeable mesh configured to enable fluids to penetrate therethrough. The system further comprises a catheter connected at a first end to one of said chamber sides/walls or penetrates therethrough; and optionally further comprises a pump placed inside or outside of said chamber.

Abstract: The invention relates to a portable ultrafiltration unit A which comprises a blood pump 7 for conveying blood and an ultrafiltration pump 6 for conveying ultrafiltrate. The invention further relates to a stationary device B for supplying dialysate to the portable ultrafiltration unit A, and to a medical treatment system which comprises an ultrafiltration unit and a device for supplying dialysate to the ultrafiltration unit. The ultrafiltration unit according to the invention is in the form of a unit to be connected to a stationary device for supplying dialysate to the ultrafiltration unit, in such a way that a fluid connection can be established for feeding in fresh dialysate and removing used dialysate. As a result, the ultrafiltration unit can not only be used for ultrafiltration, but also, when used in conjunction with the stationary device for supplying dialysate to the ultrafiltration unit, for a blood treatment as carried out by a conventional blood treatment device.

Abstract: A fluid flow sensing and bubble detecting apparatus includes a housing comprising a channel configured to receive a tube through which fluid flows; a sensor apparatus disposed within the housing, which includes a first sensor operable to measure flow rate of fluid and to detect bubbles in flowing fluid; and a temperature sensor operable to detect temperature of the flowing fluid; and a processor connected to receive fluid flow rate data obtained by the first sensor, to receive bubble detection data obtained by the first sensor, and to receive fluid temperature data obtained by the temperature sensor, wherein when a tube through which fluid flows is disposed in the channel of the housing, the first sensor measures the flow rate of the flowing fluid and detects bubbles therein, and the temperature sensor measures the temperature of the flowing fluid, and the processor calculates in a short period of time a fluid flow rate corrected for temperature.

Abstract: A package for a medical cannula with a hub, such as a pen needle, is disclosed. The package includes a cover for receiving a medical cannula and for engaging a hub of the medical cannula. The cover has open ends that are in communication through the cover. The packaging also includes a sterility barrier for the cover.

Abstract: A drug delivery device for injecting medicament, the device including a main body having a surface for contacting a patient, an actuation button (110, 420, 436) movably disposed relative to the main body, and a reservoir disposed within the main body for containing a medicament. The device also includes a needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end, wherein the lumen is fluidly connectable with the reservoir. The device further includes a removable needle cover (114, 400) for selectively covering the distal end of the needle and selectively preventing movement of the actuation button relative to the main body that initiates activation of the device.

Abstract: The present invention includes a line manager to hold and removably secure within an aperture one or more lines or tubes adjacent to a patient on or near a bed rail, body, or other device. In some embodiments, the line manager is attached to a bed rail of a hospital, or medical bed and may be used to position and label the various tubes or lines going to the patient. The line manager may be made of a flexible material and can be a single use device or a multiple use device.

Abstract: An intravenous line organizing system to be attached to patients to organize one or several IV lines, preventing entanglement and contamination by dragging on the floor, while allowing patient mobility. The hypoallergenic device can be strapped with a band around a patient's limb or torso, or adhered to the skin anywhere on the body. Each clip element allows one IV line to float freely through it. Each clip element rotates 360° and can move horizontally within a channel in the system, or it can be pushed into a locked position, preventing rotation and horizontal movement.

Abstract: Embodiments of the current disclosure are directed toward systems, devices and methods for diabetes management. In particular, the present disclosure relates to devices and methods for dispensing insulin to a patient. A portable fluid infusion device, comprising a disposable part (DP) and a reusable part (RP) is disclosed. The DP comprises a first reservoir and a second reservoir, the second reservoir less than or equal to the first reservoir in length, while the RP comprises a first compartment configured to receive the first reservoir, a second compartment configured to receive the second reservoir and a gasket for sealing a junction between the second reservoir and the second compartment upon connection of the RP and the DP.

Abstract: A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.

Abstract: The present application relates to high flow rate isolated regional treatment of cancer and proliferative disorders and conditions. For example, provided are methods, systems and devices for treating a cancer in a region of a subject using high flow rate isolated infusion.

Abstract: An infusion pump assembly includes a reservoir assembly configured to contain an infusible fluid. A motor assembly is configured to act upon the reservoir assembly and dispense at least a portion of the infusible fluid contained within the reservoir assembly. Processing logic is configured to control the motor assembly. A primary power supply is configured to provide primary electrical energy to at least a portion of the processing logic. A backup power supply is configured to provide backup electrical energy to the at least a portion of the processing logic in the event that the primary power supply fails to provide the primary electrical energy to the at least a portion of the processing logic.

Abstract: A droplet measurement system is provided with: an imaging device placed to locate a tip part of a nozzle and the entire liquid hanging down from the nozzle within a field of view; an image generation unit that generates a plurality of images that capture the state in which droplets are dripping down from the nozzle based on image data output from the imaging device; a dripping detection unit that detects, from the plurality of images, a dripping-detected image in which the fact that a droplet has departed from the nozzle is detected; and a volume calculation unit that calculates the volume of the droplet based, at least, on an image-before-dripping, which is generated a predetermined number of frames before the dripping-detected image and capturing liquid hanging down from the nozzle and on a reference image that captures at least the tip part of the nozzle.

Abstract: A visualization and analysis tool is provided for an insulin delivery system, such as an artificial pancreas, in which insulin is delivered based upon a system algorithm using a pump that is patient controllable in order to adjust insulin delivery relative to a baseline delivery rate; e.g., pre-set basal rate and a sensor for measuring glucose levels. The tool is configured with a controller of the system to detect and log events that are based on differences between actual insulin delivered by the system and the baseline delivery rate. These detected events are metrics that provide information relating to the therapeutic value of the system which, without such metrics, may be overlooked or unnoticed, thereby fostering trust and confidence in the delivery system. In addition, information is provided which may enable further improved glucose control.

Abstract: The embodiments described herein may relate to methods and systems for adjusting insulin delivery. Some methods and systems may be configured to adjust insulin delivery to personalize automated insulin delivery for a person with diabetes. Such personalization may include adjusting user specific dosage parameters in response to one or more back-filled time segments associated with a diurnal time block.

Abstract: Safety features are applied to an integrated insulin delivery system to enhance safety by controlling medication delivery including the automatic resumption of basal rate after a particular event, such as termination of a bolus, expiration of a time period, delayed resumption after the bolus has terminated, IOB comparison, and others. Other safety features include overriding a delivery control that may result in hypoglycemia, and terminating an extended bolus or temporary basal rate in view of a glucose signal indicating imminent carbohydrate deficiency. In another feature, an automatic resumption of a basal delivery rate is programmed into the delivery device to avoid the possibility of complete loss of delivery of insulin in the event that communication with the delivery device is disrupted.

Abstract: A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.

Abstract: An injection device has a plunger for displacing a stopper in a syringe or carpule, a holder for the plunger, a drive for the axial displacement of the holder of the plunger, and a control device functionally assigned to the drive. The plunger, or at least a subcomponent thereof, relative to the holder, the holder is able to move over a limited distance relative to the plunger or a subcomponent thereof, opposing a pretensioning force, in that a sensor device is included which detects the relative position of the plunger, or at least a subcomponent thereof, relative to the holder, which comprises at least one sensor element which works together with the control device. The control device is designed such that, upon activation of the sensor element, the speed of advancement of the holder of the plunger is at least reduced.

Abstract: A method of reconstituting and administering an injectable fluid distributed to practitioners in dry-form includes receiving a drug or medicine in dry form, selecting a reconstitution concentration for the drug or medicine, reconstituting a desired number of units of the drug or medicine by adding diluent to the dry-form drug or medicine, selecting a syringe having units marked according to the selected reconstitution concentration, drawing up a desired number of drug or medicine units using the selected syringe, and administering a desired number of units according to the unit markings on the selected syringe. Such a syringe includes a barrel, a plunger assembly that has a plunger handle and a piston, a needle, and a needle cap. The syringe includes a visual indicia, representing a first drug concentration contained in the barrel, that is distinguishable from a corresponding visual indicia, on a second syringe, representing a second drug concentration.

Abstract: The present disclosure relates to a medicament container assembly (11) for a medicament delivery device, comprising: an elongated body (3) configured to receive a medicament container (17) and provided with a radially flexible first gripper arm (3f) extending in the axial direction of the body (3) and an oppositely arranged radially flexible second gripper arm (3g) extending in the axial direction of the body (3), wherein the first gripper arm (3g) and the second gripper arm (3f) are configured to support a neck portion of a medicament container, and a clamp member (13) configured to be arranged radially outside of the first gripper arm (3f) and the second gripper arm (3g), to press the first gripper arm (3f) and the second gripper arm (3g) radially inwards, to prevent proximal displacement of a medicament container.

Abstract: A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. A sidewall extends between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.

Abstract: A method and apparatus for use in controlling a dispensing rate of medication or other substance via a syringe, including, without limitation, into a patient, intravenous line port or heparin lock. A force (typically manual) is applied to an input plunger of a dashpot, which is directly coupled to a piston which, in turn, is coupled to an output plunger. The force applied to the input plunger is buffered and transmitted to the output plunger. The output plunger acts upon the plunger of a conventional syringe, thereby resulting in flow of medicine or any other substance from the syringe at a desired and controlled flow rate.

Abstract: The mechanism includes a body, a drive member movable in the body, a main spring that is loaded when a dose is set and is released for moving the drive member during a delivery of a dose, and a movable trigger inhibiting a movement of the drive member, a movement of the trigger releasing the main spring and the drive member. The trigger is moved from a start position to an end position relative to the body during a setting of a dose, the end position having a distance from the start position that increases as the dose set increases.

Abstract: An injection device includes a housing and a setting part configured to, in relation to said housing, rotate in a first rotational direction when an amount of injection fluid to be dispensed is being set. The setting part rotates in a second rotational direction counter to the first rotational direction when the injection fluid is pressed out of the injection device. A latching unit defines at least one latching position of the setting part and acts between the setting part and the housing. The latching unit is active at least when the amount of injection fluid to be dispensed is set and each of the latching positions has an unequivocal rotational position of the setting part in relation to the housing assigned thereto.

Abstract: An autoinjector includes a case, a syringe carrier slidably disposed within the case and adapted to hold a syringe including a stopper, a plunger slidably disposed within the syringe carrier and adapted to apply a force on the stopper, and a drive spring disposed within the plunger and biasing the plunger relative to the syringe carrier.

Abstract: Provided is an inhaler for halotherapy having in an axial direction a proximal end for insertion into the mouth of a user, and a distal end opposite to the proximal end, wherein the inhaler comprises an inlet, an outlet arranged at the proximal end, an air passage extending from the inlet to the outlet, and a reservoir communicating with the air passage through a release orifice, the reservoir containing a dispersible substance.

Abstract: A device for detecting a flow of respiration in a conduit includes a source of a gas jet interfaced to a side of the conduit. The source of the gas jet emits a jet of gas aimed across the conduit. A main port is interfaced to a distal side of the conduit for receiving the jet of gas and a pressure-detecting device is interfaced to the main port. In absence of the flow within the conduit, the gas jet enters the main port and the pressure-detecting device reports a first pressure. In presence of the flow within the conduit, the gas jet is deflected away from the main port by the flow and the pressure-detecting device reports a second pressure, the second pressure being lower than the first pressure.

Abstract: A respiratory assistance apparatus includes a conduit connecting a flow generator and an outlet. The conduit includes a venturi formation. The apparatus further includes an oxygen inlet in fluid communication or selective fluid communication with an oxygen outlet. The oxygen outlet is directed into the conduit and toward a mouth of the venturi formation. The flow generator provides a flow path for air to enter the conduit when the flow generator is not operating.

Abstract: The present invention relates to the administration of warm humidified oxygen to patients suffering with breathing problems. The present invention more specifically relates to the high flow of warm humidified oxygen to patients suffering with breathing problems or suffering with asthma.

Abstract: Methods and system for concentrating oxygen include providing a portable apparatus having a plurality of sieve beds, each sieve bed in the plurality of sieve beds including a first end and a second end, a reservoir storing oxygen-enriched gas exiting from the second ends of the plurality of sieve beds, a compressor, an oxygen delivery valve communicating with the reservoir via a delivery line, a flow sensor associated with the delivery line, and control electronics adapted to control operation of the oxygen delivery valve; measuring, via the flow sensor, a flow of the oxygen-enriched gas through the sensor and outputting a signal indicative thereof; and controlling, using the control electronics, the opening and closing the oxygen delivery valve to deliver the oxygen-enriched gas from the reservoir to a user based on the signal.

Abstract: A bi-level positive airway pressure device includes a housing that has a patient port for connecting to an airway of a patient. Within the housing is a device that generates a positive airway pressure directed towards to patient port. Also within the housing is a system that detects exhalation (by a patient that is connected to the patient port) that enters into the patient port. Responsive to detecting exhalation, a blocking device occludes the device that generated positive airway pressure, thereby reducing or stopping the positive airway pressure. Upon the system detects abatement of exhalation, the blocking device is operated to no longer occlude the device for generating positive airway pressure, thereby providing positive airway pressure to the patient port.