Abstract: Disclosed is an injection device for delivering a medicament from a syringe contained within a housing, the device being configured to move the syringe through the housing to cause insertion of a needle of the syringe into a user's skin and move a syringe bung through a syringe body, delivering medicament through the needle. The device includes: a plunger engaging the bung; a sleeve around the plunger; an insertion spring biasing the sleeve to the housing; and a delivery spring biasing the plunger to the sleeve. A release mechanism releases the sleeve from the housing to commence insertion and release the plunger from the sleeve, following insertion, delivering medicament. A velocity regulator regulates the plunger upon release and disengages during delivery, and includes a screw thread associated with the sleeve or plunger and one or more thread engaging members formed on the other of the sleeve and the plunger.

Abstract: An injection device includes a carrier, a needle, a driver coupled to the needle, the driver being slidable relative to the carrier between a retracted configuration and a deployed configuration, a shuttle configured to move the driver between the retracted configuration and the deployed configuration, and a stop configured to move from a first configuration to a second configuration, wherein the stop is configured to maintain the driver in the deployed configuration, and movement of the stop from the first configuration to the second configuration allows the shuttle to move the driver from the deployed configuration to the retracted configuration.

Abstract: A cap assembly adapted to be attached to a drug delivery device main unit, comprising a drug-filled cartridge with an axially moveable piston and a distal portion with a needle penetratable seal, a needle assembly and a cap. The needle assembly comprises a needle having a distal skin-piercing end and a proximal seal-piercing end. The cap comprises a reservoir adapted to receive the needle distal end, the cap accommodating the needle assembly and at least the distal portion of the cartridge. The needle assembly and the cartridge are arranged axially moveable relative to each other between an initial state in which the proximal needle end is arranged distally of the cartridge seal, and an operational state in which the proximal needle end has penetrated the cartridge seal, wherein the reservoir is adapted to receive drug from the cartridge via the needle.

Abstract: Disclosed is an injection device for receiving a syringe therein and for delivering a dose of medicament from the syringe, the injection device including: an insertion driver configured to drive the syringe forwards within the injection device for inserting a needle of the syringe into an injection site; an interlock mechanism configured to retain the insertion driver in a primed state and, when actuated, to allow the insertion driver to drive the syringe forwards; and an interlock actuator moveable between a stowed position and an operable position and configured on movement from the stowed position to the operable position to couple to an actuation system such that movement from the operable position back towards the stowed position actuates the interlock mechanism.

Abstract: A cold slurry syringe with enhanced features is provided for delivering a cold slurry into the human body. The syringe includes a syringe body for holding a volume of cold slurry, a plunger that slides within the syringe body for ejecting the cold slurry, and a tapered syringe head for delivering an even flow of cold slurry. An agitator can be added to keep the cold slurry from agglomerating and clogging the syringe. Insulation added around the syringe can keep the cold slurry from melting too quickly. A ball screw drive can be added to provide a smooth and consistent application of pressure as the cold slurry is delivered. The cold slurry flow can be enhanced by adding a streamline flow feature that reduces the occurrence of eddies or swirls inside the syringe. This feature can also help maintain the composition and consistency of the cold slurry.

Abstract: A medicament delivery device comprising: a housing arranged to contain a medicament container with a piston for sealing the medicament container and displacing the medicament; a medicament delivery mechanism arranged to push the piston to displace the medicament when activated; and a driving mechanism connected to the medicament delivery mechanism such that when the medicament delivery mechanism is activated, the driving mechanism converts linear motion of the medicament delivery mechanism into torque so as to rotate a rotation member.

Abstract: A reduced profile syringe assembly is provided that includes an overall profile that is substantially similar to a profile of a syringe barrel. The syringe assembly includes a plunger rod that is significantly disposed within the syringe barrel when filled for use, with the plunger rod adapted to be retracted from the syringe barrel during dispensing of contents of the syringe barrel.

Abstract: A plunger, a syringe, and a method of making a plunger and a syringe are disclosed. The plunger includes a support ring and a cover disposed over and coupled to the support ring. A cavity defining a predetermined volume is defined between the support ring and the cover. The syringe includes a barrel defining an inner wall and the plunger inserted therein.

Abstract: A mini syringe includes a tubular base member, a microneedle unit including a microneedle device and a compressible pharmacy housing device and mounted in the bottom side of the base member, a plunger mounted in the base member and pressable to compress the pharmacy housing device, and an adjustment cover threaded onto the base member for controlling the moving distance of the plunger in a micro-adjustable manner.

Abstract: A method of manufacturing a plunger head for a medication injection device includes assembling at least a portion of a first component, assembling at least a portion of a second component, and assembling the first component into a cavity of the second component. The first component has a distal end and a proximal end, the distal end being configured for insertion into a barrel of the medication injection device before the proximal end, and the first component houses at least one electronic component. The second component is configured to at least partially surround the first component and to separate the first component from a medication contained within the barrel of the medication injection device.

Abstract: An assembly for a drug delivery device and an associated drug delivery device are provided. The device has a drug delivery device housing and a medicament contained in the drug delivery device housing. A clutch is established between the dose knob and the dial link to prevent inadvertent proximal axial movement of the lead screw away from the cartridge piston, which can lead to dosing inaccuracies.

Abstract: A syringe device includes a syringe barrel and piston having a fluid passageway extending from a vial port. Another syringe device includes a syringe barrel, a piston sleeve and an insert. A channel extends along a side of the insert. A valve controls fluid communication between the channel and the syringe barrel. Another syringe device has a syringe barrel, a piston sleeve and an insert. A valve controls fluid communication between a compartment within the insert and the syringe barrel. A method of preparing a medication includes providing a component within a syringe barrel and another component within a compartment of a piston insert. A seal is over-molded onto a tip of the insert and an end of a piston sleeve. The sleeve is rotated relative to the insert to establish fluid communication between the compartment and the barrel chamber.

Abstract: A needle protection device (10) for protecting a needle has a needle carrier (12) for carrying said needle (14) and being translatable along a longitudinal axis X between a first, deployed, position (D) and a second, protected, position (P); a shuttle (16) surrounding said needle (14); a hub (24) for receiving the needle carrier (12); a sleeve (26) being rotatable around each of said needle carrier (12), said shuttle (16) and said hub (24); a first driving mechanism (30) between said needle carrier (12) and said shuttle (16) to cause axial displacement of said shuttle (16) in a first direction (A) between a first, retracted position R and a second, deployed position Ds upon axial displacement of the needle carrier (12) along axis X; and a second driving mechanism (32) between said needle carrier (12) and said sleeve (26) to cause axial displacement of the carrier (12) in said first direction (A) upon rotational displacement of the sleeve (26).

Abstract: A device configured to receive and safely store a plurality of used needle-containing medical apparatus such as syringes, IV catheter introducers, bodily fluid collection devices and blood collection tube holders and to dispense a sterile medical apparatus having the same or a similar shape, size and configuration as that deposited into the device.

Abstract: Improved apparatus for use with medication in fluid form, which is particularly beneficial for medications having a relatively high viscosity. The disclosed syringe adapter has an opening that is relatively large, as compared to a conventional needle, and thus affixing the disclosed syringe adapter to a syringe improves syringeability of higher-viscosity medications. Some embodiments feature a lateral extension that prevents inserting the syringe adapter too far into a medicine bottle, and some embodiments feature a component that assists in firmly grasping. When the disclosed syringe adapter is affixed to a pistol-grip or tab-handled syringe, the medication withdrawn into the pistol-grip syringe can be more easily administered from the syringe barrel. In some embodiments, the syringe adapter will be replaced with a needle prior to injecting the medication, while in some other embodiments, the needle is affixed to the in-place syringe adapter for the injection.

Abstract: A spacer for a syringe for manual injection includes a mount section, a flange section and a stopper section. The mount section is adapted to be coupled to a distal end of a syringe body of the syringe. The flange section includes a contact face adapted to contact a skin surface of a patient. The stopper section has a bore extending between the mount section and the flange section wherein the stopper section is adapted to define an injection depth of a needle when being attached to the distal end of the syringe body of the syringe and extending through the bore of the stopper section.

Abstract: The invention features devices that measure the pressure of an injection or intrinsic physiologic pressures generated and measures the fluid content, e.g., blood content, of aspirated fluid during medical interventions requiring hypodermic needles, e.g., fluid sampling or medical injection procedures. The devices feature pressure and fluid content, e.g., blood, sensors that trigger indicators to alert the user of an issue during the procedure(s). The invention features a flexible cover for devices of the invention to facilitate introduction of a device into a sterile field. The invention also provides methods of using such devices and covers.

Abstract: An electronic cigarette, an atomizing assembly, and a method of manufacturing an atomizing assembly. The atomizing assembly includes a liquid absorbing unit and a heating unit. The liquid absorbing unit is configured to absorb and store liquid and the liquid absorbing unit forms an atomizing channel therein and includes an atomizing surface on which the liquid is atomized and volatilized. The atomizing surface defines a boundary of the atomizing channel through which the smoke flows. The heating unit is configured to atomize the liquid and includes a buried portion and an embedded portion connected to each other. The embedded portion is embedded in the liquid absorbing unit and is internally tangent to the corresponding atomizing surface. The buried portion is wrapped in the liquid absorbing unit, wherein a predetermined distance is designed between the buried portion and the corresponding atomizing surface in a radial direction of the atomizing channel.

Abstract: A heater assembly includes a heater extending to correspond to at least a part of a length of a cigarette and comprising one end to be inserted into the cigarette and configured to generate heat when electricity is applied; a first cover coupled to the heater to maintain a position with respect to the heater and comprising one surface that faces toward the end of the heater and extends outward from the heater; and a second cover coupled to another end of the heater and supporting another surface of the first cover facing toward the other end of the heater.

Abstract: There is provided an electronically controlled, motor-driven, breath actuated metered dose inhaler for delivering aerosolized medicament or other matter to a user. The inhaler may comprise a base housing including a motor-driven actuator and other system components and a removable aerosol cartridge insertably receivable in the base housing. The inhaler may be paired with a smart phone or other client computing device to provide additional functionality, such as to provide instructional information and feedback regarding usage of the inhaler, to generate and display dosage tracking information, and to provide alerts and reminders to a user of the inhaler or others.

Abstract: A nebulizer unit includes a housing, an aerosol generator, and an exchangeable mouthpiece. The aerosol generator is supported within the housing by a sealing ring and a retaining structure, and includes an outlet end having an integrally formed mouthpiece connector. The exchangeable mouthpiece is configured to be received by the mouthpiece connector. One side of the mouthpiece includes at least one air channel, each air channel having a first end that opens into an aerosol chamber. The aerosol chamber is delimited at an end face by the aerosol generator and circumferentially by the mouthpiece connector and the mouthpiece.

Abstract: Herein disclosed is a respiratory mask comprising a nose cushion assembly. The nose cushion assembly comprises a base body and a buffering piece. The base body is defined as having a base intake portion and a base connection portion. The base body comprises an air routing piece disposed at the inside of the base body and having a partitioning wall and a wall connection piece. The inside of the partitioning wall encloses an air intake zone. The wall connection piece is disposed outside the partitioning wall and connects with the base intake portion. Between the partitioning wall and the base intake portion there is defined an air outtake zone. The air intake zone is approximately at the center of the base intake portion. The buffering piece connects with the base connection portion and encloses a nose containing room, which in turn connects with the inside of the base body.

Abstract: A ventilator, or a breathing assistance apparatus, is disclosed to ventilate patients who may have breathing difficulties, said device comprising a inspiratory pressure control duct configured to be immersed in a first body of fluid; a positive end-expiratory pressure control duct configured to be immersed in a second body of fluid; at least one valve connected to the peak inspiratory pressure control duct and to the positive end-expiratory pressure control duct, and at least one controller communicably connected to the valve to control rate of cycling of the valve, thereby controlling number of breaths per minute, and to control the duration of peak inspiratory pressure also known as inspiratory time.

Abstract: A reservoir configured to retain a volume of liquid for use in an apparatus for humidifying a flow of pressurised air comprises a base portion and a lid portion. The reservoir may be configured to improve its level of thermal contact to the heater plate using the flow of pressurised air. The reservoir may be configured to improve thermal contact between the reservoir and the heater plate by pre-compression upon engagement of the reservoir with the humidifier. The reservoir may comprise a removable intermediate portion, which may include the inlet tube and/or the outlet tube, for improved access for cleaning. The reservoir may also be configured to prevent overfilling. Overfill prevention features in the reservoir may include defined flow egress paths and/or formation of air locks.

Abstract: A positive pressure airway device for providing resistance in an air pathway for a patient exhaling. The device includes a central tube region, a inspiratory air passageway for passing air into the central tube region when a patient breathing through the device inhales, and an expiratory air passageway for passing air out of the central tube region when a patient breathing through the device exhales, A valve in the expiratory air passageway allows air to flow out only when a patient using the device exhales with an expiratory air pressure greater than a selected pressure, and includes a stopper and a coil spring with an interior portion that is free from any structure that would inhibit the “side-to-side” movement of the spring within the housing. The stopper has a cone-shaped air-stopping surface providing a valve angle that is different from the valve-seat angle so that either laminar or oscillating flow may be obtained.

Abstract: Respiratory diseases affect a large part of world population, especially in developing world. In this invention, we present a breathing support system to provide life-saving support to such patients. The system automates and regulates the use of a bag valve mask (commonly known as an ambu bag). The system uses mechanical actuators, sensors and a smart feedback control mechanism to automate and regulate the operation of the ambu bag to implement core functions of mechanical ventilation for life-saving applications. The system can also be used to provide better breathing support to newborns (e.g. to prevent hypoxia). The system can be used to save hundreds of thousands of lives in the developing world, in emergencies and during transportation globally.

Abstract: Aspects of the present disclosure provide methods, apparatuses, and systems for closed-loop sleep protection and/or sleep regulation. According to an aspect, a biosignal parameter and ambient noise are measured. The biosignal parameter is used to determined sleep condition of a subject. The sleep condition is determined based on one or more of personalized sleep data or historical sleep data collected using a subset of society, or both. Based on the sleep condition, an arousal threshold is determined.

Abstract: A system and methods for remote Eye Movement Desensitization and Reprocessing (EMDR) therapy include performing, at therapist and client computing platforms, steps of: receiving an EMDR message indicating a position a bilateral simulation (BLS) element, wherein the BLS element is at least one of a visual, an audio, and a tactile element, and wherein the indicated position is a screen position of a visual element, or a right or left position of an audio or tactile element; and responsively presenting, on the respective computing platform the BLS element at the indicated position; and performing on the EMDR server steps of: establishing connections with the therapist and client computing platforms; and broadcasting simultaneously, over the first and second connections to both the therapist and client computing platforms, the EMDR message.

Abstract: A method of transplanting a sleep state of a first subject (donor) to a second subject (recipient) comprising: capturing a sleep state of the first subject represented by brain activity patterns; and transplanting the sleep state of the first subject in the second subject by inducing the brain activity patterns in the second subject.

Abstract: Methods of modifying the luminal profile of a body vessel are described. An example method comprises advancing a cannula out of the distal end of a catheter disposed within the lumen of a body vessel of an animal and toward a target site on the wall of the body vessel; passing contrast dye through the cannula toward the target site; simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of the body vessel at the target site; and passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site. Medical devices, medical device assemblies, and kits are also described.

Abstract: A tray (100) for accommodating a coiled medical device, such as a catheter assembly (700), includes a first compartment (101), a second compartment (102), and a third compartment (103). The catheter assembly (700) and devices associated with a catheterization procedure, such as syringes (701,702) containing sterile water and lubricating jelly and a specimen container (703) can be disposed within the tray. Printed instructions (1001) can be included with the tray (100). When a CSR wrap (1000) is disposed about the tray (100), the printed instructions can be placed atop the CSR wrap (1000) but beneath an outer sterile wrap (1002). The printed instructions (1001) can include a patient portion (1202) that is detachably coupled to a health care services portion (1201) such that it can be taken home with the patient after the procedure.

Abstract: Methods for making medical devices and portions of medical devices (e.g., intravascular catheters, catheter shafts, and tubular guiding members) are provided. Example methods may include providing a first ribbon comprising one or more thermoplastic materials and a piece of shrink tubing defining a shrink tube lumen and forming a first assembly by positioning the first ribbon inside the shrink tube lumen and urging the first ribbon to assume a tubular shape in which the first ribbon defines a ribbon lumen. A second assembly may be formed by loading an inner tubular member over a mandrel and forming or placing a support structure over an outer surface of the inner tubular member. A third assembly may be formed by inserting the second assembly into the ribbon lumen defined by the first ribbon of the first assembly. The third assembly may be heated to a process temperature.

Abstract: Described herein are devices and methods for guide catheters having one or more regions of increased flexibility. A flexibility region comprises one tubular segment of the guide catheter with a non-linear longitudinal seam between two non-concentric layers of material having different durometers. A non-linear seam, such as a zig-zag or sinusoidal configuration, permits controlled compression of lower durometer material between portions of higher durometer material.

Abstract: A method of treating an anatomical cavity of a patient comprises introducing an infusion/aspiration catheter into the patient, such that a plurality of arms of the catheter reside within the anatomical cavity, delivering a fluid into the at least one of a connector, such that fluid exits the at least one fluid port of at least one of the arms, thereby infusing the anatomical cavity with the fluid, and aspirating the fluid into the at least one fluid port of at least one of the arms, such that the fluid exits the connector(s).

Abstract: A wall (39) of a catheter (38) (a) includes a braided portion (41) having an outer surface (45), an inner surface (47), and a braided interior (53) between the outer and inner surfaces (45, 47), and (b) is shaped to define first and second longitudinally-running channels (27a, 27b) therethrough. A distal portion of the catheter (38) is shaped to define first and second lateral openings (26a, 26b). An angle between (a) a first line (76) running between the first and second lateral openings (26a, 26b), and (b) a second line (78) that is parallel to a central longitudinal axis of the catheter (38) when the catheter (38) is straight, is between 30 and 150 degrees.

Abstract: An orientable catheter (10, 110, 210) comprising a first tubular body (16, 116, 216) having a distal portion with shape memory (26, 126, 226) which is curved at rest, and a second tubular body (38, 138, 238) having a distal stiffening portion (54, 154, 254) forming a stiffening element capable of sliding relative to the first tubular body (16, 116, 216) between a stiffening position in which the stiffening element (54, 154, 254) imposes a straightened configuration on the distal portion with shape memory (26, 126, 226), and a retracted position in which the stiffening element (54, 154, 254) does not interfere with the resting curved configuration of the distal end with shape memory (26, 126, 226).

Abstract: An intravascular imaging system includes a catheter with an elongate outer sheath and a torque cable axially translatable and rotatable in the elongate outer sheath, a pullback and rotation unit for axially translating and rotating the torque cable, a sensor configured to provide an output indicative of an axial force exerted by the torque cable on a rotor in the pullback and rotation unit, and a controller configured to cause the pullback and rotation unit to operate in a remedial mode if the output exceeds a predetermined threshold.

Abstract: A robotic surgical system configured for the articulation of a catheter comprises an input device, a control computer, and an instrument driver having at least one motor for displacing the pull-wire of a steerable catheter wherein the control computer is configured to determine the desired motor torque or tension of the pull-wire of a catheter based on user manipulation of the input device. The control computer is configured to output the desired motor torque or tension of the pull-wire to the instrument driver, whereby at least one motor of the instrument driver implements the desired motor torque to cause the desired pull-wire tension to articulate the distal tip of the catheter.

Abstract: Embodiments include a catheter anchoring device for securing a percutaneous medical catheter inserted at a skin puncture site to a skin of a body. The catheter anchoring device may include a catheter capture portion coupled to a skin attachment portion. The catheter capture portion may be configured to engage with a portion of the catheter protruding from the skin when the catheter is subcutaneously placed in a body. The skin attachment portion may be configured to adhesively attach the anchoring device to the skin, wherein the skin attachment portion is primarily attached to the skin overlaying and lateral to the subcutaneously located catheter.

Abstract: A device for guiding and supporting a stent delivery catheter and other catheters is disclosed. The device may comprise a tubular guiding member and an elongated positioning member extending in a proximal direction beyond the tubular guiding member for advancing and retracting the tubular guiding member in distal and proximal directions. A distal portion of the elongate positioning member may be coupled to the proximal portion of the tubular guide. In embodiments, the device includes a ribbon having a distal portion and a proximal portion. In embodiments, the distal portion of the ribbon extends distally into the tubular guiding member and the proximal portion of the ribbon overlays an inner surface of the elongate positioning member.

Abstract: A tube element for a device for introduction into a body passage comprises a first tube element end and a second tube element end, wherein a longitudinal dimension is formed between the first and second tube element end. The tube element has a sheath comprising an outer wall and an inner wall. A cross-sectional element is arranged between the first and second tube element ends. The cross-sectional element contains a plurality of opening arrangements. Each opening arrangement comprises a first opening containing an insert element and a second opening, the internal pressure of which can be changed by a pressure changing means.

Abstract: A guidewire for medical procedures can be maintained in a coiled configuration with a clamp. Multiple clamped and coiled guidewires may be stored in a fluid-filled, storage bowl concurrently. Different clamps may have different colors to differentiate the clamps and clamped guidewires. The clamps may be markable to provide additional differentiation. The clamps can further comprise a guidewire introduction funnel and/or a guidewire torquer.

Abstract: Guidewire retainers for use with catheters and related methods and kits are disclosed. According to an aspect, a guidewire retainer includes a body that defines an interior space therein and an opening at one end that provides passage from an exterior of the body to the interior space. The interior space can be shaped and sized for holding an end of a guidewire. The guidewire retainer also includes a locking mechanism configured to close the body for attaching the body to the end of the guidewire.

Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, nonalcoholic fatty liver disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

Abstract: A delivery system for delivering an implant to a first space within a body of a patient including an elongate delivery member having a proximal portion, a distal portion, a lumen and a receiving area, the receiving area dimensioned for receipt of the implant. A deforming member is movable with respect to the delivery member from a first position to a second position to apply a force to the implant to deform the implant positioned in the receiving area of the delivery member.

Abstract: A dilator tip may include an elongated tubular member defined by a circumferential wall and having a distal tip region and a proximal end, and a plurality of ribs extending longitudinally between the distal tip region and the proximal end. The plurality of ribs may extend radially outward from the elongated tubular member, and the plurality of ribs may be spaced apart circumferentially.

Abstract: A medical device for dilating urethral strictures comprises a urethral catheter disposed inside a slidable sheath. The device includes a localizing balloon and one or more dilating balloons capable of expanding radially outward to mechanically expand the urethral stricture. In certain embodiments, the device is adjustable in order to position the location of the one or more dilating balloons of the device relative to the urethral stricture of a patient.

Abstract: A spray device for dispensing a product includes a canister, a wand attached to the canister by a ball joint, a manually actuatable valve connecting the canister to the wand for dispensing a product through a nozzle at a free end of the valve. The wand may be telescoping. Applicator attachments are provided for securing to the free end of the wand for varying the delivery.

Abstract: A medical liquid supply device that includes: a container including a containing portion with a mouth (16); an interior cap (30); and an exterior cap (60). The interior and exterior caps (30, 60) include a ratchet mechanism (50, 80). The interior cap (30) includes: an interior-cap main body (32) and an interior-cap protrusion (54). The interior-cap main body (32) includes a contact ring (44). The exterior cap (60) includes: an exterior-cap main body (62); and an exterior-cap protrusion (84) configured to be engaged with the interior-cap protrusion (54). The contact ring (44) is distant from the interior-cap protrusion (54) in the radial direction of the interior-cap main body (32).

Abstract: A dermal adhesive patch is provided. The dermal adhesive patch according to an exemplary embodiment of the present invention is adhered to skin through an ampoule containing a mixing ingredient, a drying ingredient, a viscosity control ingredient, and a moisturizing ingredient. The dermal adhesive patch comprises: a support body; and a membrane layer formed as a nanofiber web having pores to block moisture and to allow air to pass through the membrane layer, and detachably laminated on one surface of the support body.