Patents Issued in May 12, 2020
  • Patent number: 10647925
    Abstract: Fuels and/or fuel blending components can be formed from hydroprocessing of high lift deasphalted oil. The high lift deasphalting can correspond to solvent deasphalting to produce a yield of deasphalted oil of at least 50 wt %, or at least 65 wt %, or at least 75 wt %. The resulting fuels and/or fuel blending components formed by hydroprocessing of the deasphalted oil can have unexpectedly high naphthene content and/or density. Additionally or alternately, deasphalted oil generated from high lift deasphalting represents a disadvantaged feed that can be converted into a fuel and/or fuel blending components with unexpected compositions. Additionally or alternately, the resulting fuels and/or fuel blending components can have unexpectedly beneficial cold flow properties, such as cloud point, pour point, and/or freeze point.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: May 12, 2020
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Sheryl B. Rubin-Pitel, Kenneth Kar, Kendall S. Fruchey
  • Patent number: 10647926
    Abstract: An apparatus and process for desulfurization of hydrocarbon feeds is disclosed in which pure nitrous oxide, or a mixture of nitrous oxide and oxygen or air, is used as a gaseous oxidant. Organosulfur compounds are converted to their corresponding oxides sulfones and/or sulfoxides in an oxidation reactor, and oxides are subsequently removed from the oxidation reactor effluent to recover a reduced sulfur-content hydrocarbon product.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: May 12, 2020
    Assignee: SAUDI ARABIAN OIL COMPANY
    Inventors: Abdennour Bourane, Omer Refa Koseoglu
  • Patent number: 10647927
    Abstract: The invention relates to a method of increasing the American Petroleum Institute (API) gravity of feedstocks by reacting one or more mono-cyclic ether solvents such as oxolane with the asphaltene resident in bitumen or crude oils, at an ambient or elevated temperature, and at ambient or elevated pressure, to increase the API gravity and the economic value of the bitumen or crude oil, and a method for in situ manufacturing a mono-cyclic ether, oxolane, to rejuvenate bitumen or heavy crude oils into their younger lighter crude oils by blending methyl linoleate and methanol in a ratio; heating to produce oxolane; and contacting the oxolane as a solvent with the asphaltene resident in bitumen and heavy crude oils to release not only aromatic compounds, represented by toluene, but also the paraffinic alkanes, represented by n-heptane, making the feedstocks ready for extraction, separation of sand, pipeline transport and refining.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: May 12, 2020
    Assignee: DPD Chemical Inc.
    Inventor: Mathew M. Zuckerman
  • Patent number: 10647928
    Abstract: Methods and systems for converting inactive chemicals into active chemicals in-situ for treating oil and gas pipelines, other industrial systems, or sanitizing surfaces. Also, methods of treating an oil and gas pipeline including feeding an inactive additive through a first conduit and into a second conduit, the second conduit is in fluid communication with the first conduit and the oil and gas pipeline. The inactive additive is converted into an active additive within the second conduit and introduced into the oil and gas pipeline.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: May 12, 2020
    Assignee: ECOLAB USA INC.
    Inventor: Jeremy Moloney
  • Patent number: 10647929
    Abstract: The present invention relates to a method for converting heavy oil by means of high dispersion of asphaltenes, comprising the steps of: preparing a mixture by mixing an amphiphilic additive and the heavy oil; and performing a hydrogenation reaction on the mixture, wherein the amphiphilic additive comprises both a polar group and a nonpolar group.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: May 12, 2020
    Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Chul Wee Lee, Joung Mo Cho, Sun Young Park
  • Patent number: 10647930
    Abstract: The present invention relates to a hydrocracking reactor system and a process utilizing the same for upgrading heavy hydrocarbonaceous material to value-added products. Accordingly, an aspect of the present invention includes dispersing a liquid feedstock pre-mixed with a catalyst from top of a reactor vessel to obtain dispersed droplets having a predetermined droplet size less than 500 ?m, introducing a gaseous feed comprising primarily of hydrogen from bottom of the reactor vessel to form a continuous gaseous phase throughout a cross-section of the reactor vessel, and allowing the dispersed droplets to contact the continuous gaseous phase throughout the cross-section of the reactor vessel to form reaction effluent comprising one or more lighter product hydrocarbons. The method may further include removing at least a top portion and at least a bottom portion of the reaction effluent from the reactor vessel.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: May 12, 2020
    Assignee: INDIAN OIL CORPORATION LIMITED
    Inventors: Mainak Sarkar, Darshankumar Manubhai Dave, Ramesh Karumanchi, Madhusudan Sau, Ganesh Vitthalrao Butley, Nepal Vishwakarma, Kamal Kumar, Pravesh Kumar, Sarvesh Kumar, Debasis Bhattacharyya, Sanjiv Kumar Mazumdar, Sankara Sri Venkata Ramakumar
  • Patent number: 10647931
    Abstract: The invention concerns a process for the production of middle distillates, comprising at least one step for the catalytic oligomerization of a feed comprising olefins containing 3 to 9 carbon atoms, in which the reaction section comprises at least two reactors which are positioned in series and which can be permutated, each containing at least one oligomerization catalyst for the oligomerization reactions, said catalysts being identical or different, and in which the reactor which is the furthest downstream in the direction of movement of said feed comprising olefins contains the catalyst with a period of service which is shorter than the period of service of the catalysts present in the other reactors and is operated at an average temperature (WABTn) which is lower than the average temperature (WABTn?1) of the reactor directly preceding it, the difference between said average temperatures being at least 10° C. (WABTn?1?WABTn?10° C.).
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: May 12, 2020
    Assignee: AXENS
    Inventors: Annick Pucci, Marielle Gagniere
  • Patent number: 10647932
    Abstract: Process and apparatuses for producing benzene and para-xylene from a reformate stream is provided. The process comprises separating the reformate stream to provide a first stream comprising C4 and lighter hydrocarbons and a second stream comprising aromatic hydrocarbons. The second steam is provided to a reformate splitter to provide a reformate bottoms stream comprising C8+ aromatic hydrocarbons and a reformate overhead stream comprising C7? aromatic hydrocarbons. The reformate overhead stream is passed to an aromatics extraction unit to provide an aromatics extract stream comprising benzene and toluene and a raffinate stream comprising non-aromatic hydrocarbons. The reformate bottoms stream and one of the first stream and the raffinate stream is passed to an olefin reduction zone, wherein the reformate bottoms stream and one of the first stream and the raffinate stream are contacted with an olefin saturation catalyst under olefin saturation conditions to produce an olefin-treated reformate stream.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: May 12, 2020
    Assignee: UOP LLC
    Inventors: Jalesh Kalra, Robert J. L. Noe
  • Patent number: 10647933
    Abstract: Hydropyrolysis processes that accompany the generation of activated carbon as an end product, as well as processes for the production of activated carbon from hydropyrolysis char, are described. Representative processes comprise upgrading, by steam activation, char that is formed from solid biomass-containing feedstocks and/or solid biomass derived feedstocks, such as lignocellulosic feedstocks (e.g., wood). Such processes are associated with a number of advantages in terms of achieving operating synergies, obtaining desirable intermediate material and end product properties, reducing environmental impact, and significantly improving economic attractiveness.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: May 12, 2020
    Assignee: Gas Technology Institute
    Inventors: Terry L. Marker, Martin B. Linck, Michael J. Roberts
  • Patent number: 10647934
    Abstract: Methods for deriving a low-C hydrocarbon fuel from a platform chemical mixture are provided by introducing the platform chemical mixture to a catalytic material to produce a product stream comprising the low-C hydrocarbon fuel, and separating the low-C hydrocarbon fuel in the product stream from any remaining platform chemicals. Methods for producing aromatic hydrocarbons benzene, toluene, and xylenes from a platform chemical mixture are also provided by introducing a catalytic material to the platform chemical mixture to produce a immiscible liquid product stream comprising BTX, and separating the BTX in the liquid product stream from unreacted platform chemicals via a decanting process.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: May 12, 2020
    Assignee: University of South Carolina
    Inventors: Jochen A. Lauterbach, Sungtak Kim, Erdem Sasmaz, Michael Mayeda
  • Patent number: 10647935
    Abstract: A process for cleaning and beneficiating biomass is described which may allow removal of entrained salts and light volatiles from biomass materials. The process may also minimize energy use through capturing steam and flue gases for re-use. The process may generally comprise the following steps: prewashing and/or preheating a biomass, pressurizing the biomass in a steam explosion vessel, rapidly depressurizing the steam explosion vessel, releasing the steam from the steam explosion vessel entrained with fine lignin-enriched particles into a cyclone-type gas expansion vessel, routing the steam from the gas expansion vessel to the input hopper, subjecting the biomass to a second washing step, mechanically removing a portion of the water from the biomass. After the biomass has been steam-exploded, it may be washed and used as an engineered soil.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: May 12, 2020
    Assignee: ACTIVE ENERGY GROUP PLC
    Inventors: Philip J. Scalzo, Carleton D. Tait, Ronald A. Cella
  • Patent number: 10647936
    Abstract: A method for improving filterability, while maintaining or improving antifoaming performance, of a lubricating oil in an engine or other mechanical component lubricated with the lubricating oil by using as the lubricating oil a formulated oil. A method for improving antifoaming performance, while maintaining or improving filterability, of a lubricating oil in an engine or other mechanical component lubricated with the lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition including a lubricating oil base stock as a major component, and at least one antifoam agent, as a minor component. A lubricating oil having a composition including a lubricating oil base stock as a major component, and at least one antifoam agent, as a minor component. The antifoam agent is a silicone composition having a highly branched functionalized silicone backbone. The lubricating oils are useful as automotive gear lubricating compositions.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: May 12, 2020
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Michael L. Blumenfeld, Angela S. Galiano-Roth, Wenning W. Han
  • Patent number: 10647937
    Abstract: Provided is a mineral base oil having a kinematic viscosity at 40° C. of 4.0 mm2/s or more and less than 6.0 mm2/s, a kinematic viscosity at 100° C. of 1.0 mm2/s or more and less than 2.0 mm2/s, and a flash point of 140° C. or higher. A lubricating oil composition containing the mineral base oil has a high flash point while having a low viscosity and thus having excellent fuel-saving performance when used as a driving system oil and the like.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: May 12, 2020
    Assignee: IDEMITSU KOSAN CO., LTD.
    Inventors: Norihiro Kuroda, Hisao Anzai, Kenji Goto
  • Patent number: 10647938
    Abstract: The presently disclosed technology relates to a nano-additives to improve the performance of lubricants, oils, and greases. More specifically, the presently disclosed technology relates to applying capped metal oxide nanoparticles, such as capped zirconia nanoparticles, in the lubricants to produce a tribofilms on the lubricating surfaces to provide wear protection to the said surfaces. Also, the interaction of the capped zirconia nanoparticles with other commonly used additives in lubricants may further optimize the performance of the resulting tribofilms.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: May 12, 2020
    Assignees: PIXELLIGENT TECHNOLOGIES, LLC, UCHICAGO ARGONNE, LLC, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Imene Lahouij, Robert Carpick, Andrew Jackson, Harman Khare, Nitya Gosvami, Nicholaos G. Demas, Robert A. Erck, Aaron C. Greco, George R. Fenske, Wei Xu, Gregory Cooper, Zhiyun Chen
  • Patent number: 10647939
    Abstract: Provided herein are compositions that include a thiadiazole component and a solubility enhancing component. The solubility enhancing component can include a dispersant, a detergent, or both a dispersant and a detergent. The thiadiazole component can include one or more species having a hydrocarbyl-disulfanyl moiety. The compositions may be used as a corrosion inhibitor. Also provided herein are methods for making a thiadiazole component and a composition.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: May 12, 2020
    Assignee: International Petroleum Products & Additives Company, Inc.
    Inventors: Xingguo R. Chen, Jeffrey A. Crow, Troy R. Haynes, Jonathan A. Crow, Brian J. Cereghino
  • Patent number: 10647940
    Abstract: Provided are a lubricating oil composition containing a base oil and a specific thiophosphate compound (A) and not substantially containing a molybdenum-based, and a precision reduction gear using the lubricating oil composition. The lubricating oil composition and the precision reduction gear using it exhibit excellent wear resistance and can prevent sludge generation in a broad range of contact pressures ranging from high to low.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 12, 2020
    Assignee: IDEMITSU KOSAN CO., LTD.
    Inventor: Takuya Ono
  • Patent number: 10647941
    Abstract: A defoaming agent comprising: a polymer comprising a repeating unit represented by the following general formula (1): where in the general formula (1), X1 is a repeating unit obtainable by polymerization of an ethylenic unsaturated group; Y1 is a side chain comprising a linear or branched polysiloxane structure, the polysiloxane structure comprising a repeating unit represented by the following general formula (2) and having a polymerization degree of 5 to 300; and Z1 is a linking group linking the repeating unit X1 and the side chain Y1; wherein in the general formula (2), R1 and R2 are each independently an organic group having a carbon number of 1 to 18.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: May 12, 2020
    Assignee: JXTG NIPPON OIL & ENERGY CORPORATION
    Inventors: Akira Takagi, Shingo Matsuki
  • Patent number: 10647942
    Abstract: The present disclosure is directed to the synthesis and application of undecavertol derivatives having unique and desired flavor and/or fragrant characteristics. The compounds of the present disclosure can be employed alone or incorporated as fragrance or flavor ingredients in fragrance or flavor compositions. The present disclosure is also directed to consumer products comprising such derivatives and/or fragrance or flavor compositions.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: May 12, 2020
    Assignee: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Maureen Blandino, Michael E. Lankin
  • Patent number: 10647943
    Abstract: Systems and methods are described for forming wax shells for use with electric lighting devices. A template can comprise a sleeve that defines an interior space with a removable core at least partially disposed within the interior space. A modular top can be coupled to the sleeve, depending on the desired upper surface of the wax shell.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: May 12, 2020
    Assignee: Luminara Worldwide, LLC
    Inventors: Douglas Patton, James LaBelle, Jeffrey Thompson, Xiaohua Wan
  • Patent number: 10647944
    Abstract: Cleaning compositions with improved sudsing profiles are provided, which contain a high level of one or more branched and unethoxylated C6-C14 alkyl sulphate anionic surfactants as a primary surfactant, with little or no alkoxylated alkyl sulfate and preferably without any suds suppressors. Such cleaning compositions are particularly suitable for hand-washing dishes or fabrics.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: May 12, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Ming Tang, Qing Chen, Wenting Liu
  • Patent number: 10647945
    Abstract: The invention relates to the use of a gel-like polymer composition, which is produced by means of a radical polymerization of an [alpha],[beta]-ethylenically unsaturated acid in the presence of at least one polyether component, in formulations for automatic dishwashing (ADW).
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: May 12, 2020
    Assignee: BASF SE
    Inventors: Heike Weber, Yannick Fuchs, Helmut Witteler, Roland Boehn, Ralph Rieger
  • Patent number: 10647946
    Abstract: The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: May 12, 2020
    Assignee: NOVOZYMES A/S
    Inventors: Carsten Andersen, Chakshusmathi Ghadiyaram, Rajendra Kulothungan Sainathan, Padmavathi Balumuri, Padma Venkatachalam Iyer, Iben Damager, Astrid Munch, Sohel Dalal
  • Patent number: 10647947
    Abstract: The present invention concerns a detergent comprising a polypeptide having galactanase activity. It further concerns a laundering method and the use of galactanases. The present invention further relates to polypeptides having galactanase activity, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: May 12, 2020
    Assignee: Novozymes A/S
    Inventors: Lilian Eva Tang Baltsen, Kirk Matthew Schnorr, Klaus Gori, Lars Kobberoe Skov
  • Patent number: 10647948
    Abstract: The need for a fast acting and broad spectrum antimicrobial composition which does not reduce surface shine and does not leave visible residues on the surface, while also providing greater residuality of the actives can be met by formulating antimicrobial compositions as described herein.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: May 12, 2020
    Assignee: The Procter & Gamble Company
    Inventors: Alan Edward Sherry, Molly Pelon Bohlen, Samuel Kimani Njoroge, LaShanda Marie Glenn, Janice Lynn Dhonau, Christopher Todd Morrissey, Jamesina Anne Fitzgerald, Phillip Kyle Vinson, Melinda Phyllis Steffey, Rafael Ortiz, Benjamin Patrick Hale, Yonas Gizaw, Roy Jerome Harrington, Peter Herbert Koenig, Nicola John Policicchio, Stefano Scialla, Steven Daryl Smith, Matthew Scott Wagner
  • Patent number: 10647949
    Abstract: A cleaning composition for sanitizing and/or disinfecting hard surfaces, comprising: a cationic biocide, surfactant and low levels of VOC solvents. The cleaning composition is adapted to clean a variety of hard surfaces without leaving behind a visible residue and creates low levels of streaking and filming on the treated surface. The cleaning composition contains less than 5% by weight of VOCs. The cleaning composition may be used alone as a liquid or spray formulation or in combination with a substrate, for example, a pre-loaded cleaning wipe.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: May 12, 2020
    Assignee: The Clorox Company
    Inventors: Diana Mitchell, Sarah Coulter, Ashish Jha, William Ouellette, Gregory van Buskirk
  • Patent number: 10647950
    Abstract: A composition and method for removing copper-containing post-etch and/or post-ash residue from patterned microelectronic devices is described. The removal composition includes water, a fluoride ion source, an alkanolamine, sulfuric acid, and an organic acid. The compositions effectively remove the copper and cobalt-containing post-etch residue from the microelectronic device without damaging exposed low-k dielectric and metal interconnect materials.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: May 12, 2020
    Assignee: VERSUM MATERIALS US, LLC
    Inventors: Seiji Inaoka, William Jack Casteel, Jr., Wen Dar Liu
  • Patent number: 10647951
    Abstract: The present invention relates to the production of fermented fruit beverages, such as wine and cider, with a reduced level of alcohol. Specifically, the present invention is directed to a method for producing a beverage with a reduced content of alcohol comprising using reverse inoculation or co-inoculation of homofermentative or facultative heterofermentative lactic acid bacterium strain and a yeast strain.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: May 12, 2020
    Assignee: CHR. HANSEN A/S
    Inventors: Sofie Saerens, Nathalia Edwards, Kim Ib Soerensen, Mansour Badaki, Jan Hendrik Swiegers
  • Patent number: 10647952
    Abstract: An all-natural fruit juice, vegetable juice or blend of fruit juice and vegetable juice and alcohol composition, including a mixture of all-natural fruit juice, vegetable juice or blend of fruit juice and vegetable juice and alcohol having a pH of less than or equal to 4.6, wherein the mixture has an alcohol content of 2-20% by volume, and wherein the mixture has been subjected to a high-pressure processing such that the mixture has been subjected to a pressure range of 70,000-95,000 psi for a time period of 1 to 5 minutes.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: May 12, 2020
    Inventors: Shawn Lawless, Catherine Ragozzino
  • Patent number: 10647953
    Abstract: An article suitable for inducing quasispherical cell clustering is provided. The article comprising: a layer suitable for culturing quasispherical cell clusters, the layer comprising a bulk region comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte and at least one predominantly negatively charged positive polyelectrolyte, a back surface region, and a front surface region, wherein the front surface region comprises a net negative fixed surface charge density of between about 0.4 micromole per m2 and about 1.5 micromole per m2.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: May 12, 2020
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Joseph B. Schlenoff, Carlos Arias
  • Patent number: 10647954
    Abstract: A cell culture cartridge is provided comprising a plurality of zones geometrically configured to provide for symmetrical fluid flow with each of the plurality of zones to avoid dead areas in flow within each of the plurality of zones. In certain embodiments, at least eight inlets are provided, with an inlet positioned at each corner of the cell culture cartridge. In certain embodiments, a shared outlet is positioned on a top surface of the cell culture cartridge.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: May 12, 2020
    Assignee: FLASKWORKS, LLC
    Inventor: Andrew Kozbial
  • Patent number: 10647955
    Abstract: An operation isolator forms an aseptic space. An incubator is connected to the operation isolator, in which cells are stored and cultured. A storage chamber stores articles used in the operation isolator. In order to carry articles from the outside into the storage chamber, a decontamination pass-box is provided. The storage chamber and the operation isolator are directly or indirectly connected to each other.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: May 12, 2020
    Assignees: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, BIOMEDICA SOLUTIONS CO., LTD., SHIBUYA CORPORATION
    Inventors: Hideki Taniguchi, Takanori Takebe, Keisuke Sekine, Atsushi Nakao, Takashi Hiromatsu, Hironobu Sunayama, Tetsuya Nishimura
  • Patent number: 10647956
    Abstract: The purpose of the present invention is to provide a method for isolating, removing and analyzing cells. Provided is a method for isolating, removing and analyzing cells by filtering a liquid specimen containing cells through a porous polyimide film, and subjecting the cells captured by the film which did not pass through the porous polyimide film, or the cells in the liquid specimen which did pass through the porous polyimide film, to an examination of one or more cell properties selected from a group consisting of cell number or type, internal or external cell structure, type or amount of cell surface antigen, type or amount of material secreted from cells, cell adhesion, and cell survival rate.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: May 12, 2020
    Assignees: UBE INDUSTRIES, LTD., UNIVERSITY OF TSUKUBA
    Inventors: Akiyoshi Fukamizu, Jun-Dal Kim, Masahiko Hagihara, Yukinori Wada
  • Patent number: 10647957
    Abstract: Methods, devices and kits for the physical separation of plankton into its component parts utilizing phototactic behavior are described. The methods utilize positive phototactic behavior and negative contrast orientation of the zooplankton for maximal in situ separation of phytoplankton and zooplankton for use in further studies and evaluation of separation efficiency. The devices provide effective conditions for use in the separation of plankton into component parts.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: May 12, 2020
    Inventor: Nancy Leland
  • Patent number: 10647958
    Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: May 12, 2020
    Assignee: Inscripta, Inc.
    Inventors: Phillip Belgrader, Don Masquelier, Bruce Chabansky, Jorge Bernate, Andrew Garst, Richard Fox
  • Patent number: 10647959
    Abstract: The invention provides polymer scaffolds for cell-based tissue engineering.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: May 12, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: David J. Mooney, Jaeyun Kim, Sidi A. Bencherif, Weiwei Aileen Li
  • Patent number: 10647960
    Abstract: The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: James Eberwine, Jai-Yoon Sul, Chia-Wen Wu, Fanyi Zeng, Junhyong Kim
  • Patent number: 10647961
    Abstract: This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: May 12, 2020
    Assignees: Mayo Foundation for Medical Education and Research, University of Washington
    Inventors: Peter A. Cohen, Sandra J. Gendler, Latha B. Pathangey, Dustin B. McCurry, Jessica E. Gorman, Mary L. Disis
  • Patent number: 10647962
    Abstract: An aluminoborate glass composition, including B2O3, Al2O3, P2O5, Na2O, and CaO, as defined herein. Also disclosed are bioactive compositions including the disclosed aluminoborate glass composition, a suitable fluid, and at least one live cell. Also disclosed is method of limiting the amount of boron released into an aqueous solution from a disclosed aluminoborate-containing glass composition as defined herein. Also disclosed is a method of proliferating cells on a bioactive substrate as defined herein.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: May 12, 2020
    Assignee: Corning Incorporated
    Inventors: Huayun Deng, Ye Fang, Qiang Fu, John Christopher Mauro
  • Patent number: 10647963
    Abstract: The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to cancer therapies of humans. More specifically, the present invention relates to oncolytic adenoviral vectors alone or together with therapeutic compositions for therapeutic uses and therapeutic methods for cancer. In one aspect the present invention relates to separate administration of adoptive cell therapeutic composition and oncolytic adenoviral vectors. Furthermore, the present invention relates to a pharmaceutical kit and a pharmaceutical composition, both utilizing oncolytic adenoviral vectors.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: May 12, 2020
    Assignee: TILT BIOTHERAPEUTICS OY
    Inventors: Akseli Hemminki, Markus Vaha-Koskela, Siri Tahtinen, Vincenzo Cerullo
  • Patent number: 10647964
    Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: May 12, 2020
    Assignees: Northwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College
    Inventors: Gregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
  • Patent number: 10647965
    Abstract: The present invention relates to a hetero-transglycosylase protein having cellulose:xyloglucan endotransglucosylase (CXE) activity in addition to mixed-linkage beta-glucan:xyloglucan endotransglucosylase (MXE) activity. The protein may comprise the amino acid sequence of any one of SEQ ID NOs: 2, 6 and 8 or a functional fragment thereof; or an amino acid sequence having at least 60% sequence identity to any one of SEQ ID NO: 2, 6 and 8, or to SEQ ID NO: 2 from amino acid 22 to 280, to SEQ ID NO: 6 from amino acid 26 to 283, or to SEQ ID NO: 8 from amino acid 29 to 287. The invention furthermore relates to an isolated nucleic acid encoding the protein described herein, a chimeric gene comprising, inter alia, the nucleic acid described herein, a vector comprising said chimeric gene, a host cell comprising said vector or said chimeric gene and an according transgenic plant. Further disclosed herein in are a method of producing a transgenic plant and a method of improving properties of cellulosic material.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: May 12, 2020
    Assignees: BASF SE, THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventors: Frank Meulewaeter, Ilse Van Den Brande, Stephen C. Fry, Kyle E. Mohler, Lenka Frankova, Tom J. Simmons, Claire Holland, Andrew Hudson
  • Patent number: 10647966
    Abstract: Disclosed are mutant DNA polymerases having increased 3?-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: May 12, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Fred Reichert, Keith Bauer, Thomas W. Myers
  • Patent number: 10647967
    Abstract: Disclosed are mutant DNA polymerases having increased 3?-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: May 12, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Fred Reichert, Keith Bauer, Thomas W. Myers
  • Patent number: 10647968
    Abstract: The present invention discloses a new anti-tumor medicament comprising a mutant of endostatin. The mutant comprises a mutation in the ATP-binding site of endostatin and has a decreased ATPase activity and an increased anti-angiogenesis activity.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: May 12, 2020
    Assignees: Tsinghua University, Beijing Protgen Ltd.
    Inventors: Yongzhang Luo, Peng Liu, Xinan Lu, Yang Chen, Yan Fu, Guodong Chang, Daifu Zhou
  • Patent number: 10647969
    Abstract: The disclosure relates, in general, to Glycogen Storage Disease and, in particular, to a method of treating Glycogen Storage Disease Type IX and to compounds and compositions suitable for use in such a method, including acid alpha-glucosidase.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: May 12, 2020
    Assignee: Duke University
    Inventors: Yuan-Tsong Chen, Priya Kishnani, Baodong Sun
  • Patent number: 10647970
    Abstract: The present invention discloses an L-type amylase variant and use thereof. The ?-amylase variant is obtained by deleting the first N-terminal amino acid residue V from the ?-amylase of B. licheniformis and replacing it with three other amino acid residues DGL. The ?-amylase variant provided by the present invention has high catalytic activity under the acidic conditions of pH 5.0-5.8 and a high temperature of 100° C. or above. The acid resistance and thermal stability of these ?-amylase variants are suitable for starch liquefaction.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: May 12, 2020
    Assignee: Nanjing Bestzyme Bio-Engineering Co., LTD.
    Inventors: Yan Fan, Yan Sun, Hong Xu
  • Patent number: 10647971
    Abstract: The present invention relates to isolated polypeptides having cellulolytic activity or hemicellulolytic activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: May 12, 2020
    Assignee: Novozymes A/S
    Inventors: Lene Lange, Peter K. Busk
  • Patent number: 10647972
    Abstract: The present invention relates to methods for obtaining positive transformants of a filamentous fungal host cell, comprising: transforming a tandem construct into a population of cells of the filamentous fungal host a tandem construct and isolating a transformant of the filamentous fungal host cell comprising the tandem construct. The present invention also relates to such tandem constructs, filamentous fungal host cells comprising such tandem constructs, and methods of producing multiple recombinant proteins.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: May 12, 2020
    Assignee: Novozymes, Inc.
    Inventor: Donna Moyer
  • Patent number: 10647973
    Abstract: A novel mannanase. A polypeptide having a specific amino acid sequence such as the amino acid represented by SEQ ID NO:2 exhibits a mannanase activity. Although this mannanase does not have homology with known mannanase at the amino acid level, the polypeptide has a mannanase activity as well as heat resistance.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: May 12, 2020
    Assignee: MEIJO UNIVERSITY EDUCATIONAL FOUNDATION
    Inventors: Motoyuki Shimizu, Masashi Kato
  • Patent number: 10647974
    Abstract: The present invention relates to novel subtilase variants exhibiting increased stability and optionally on par or improved wash performance. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: May 12, 2020
    Assignee: Novozymes A/S
    Inventors: Jens Erik Nielsen, Pernille Ollendorff Hede, Jurgen Carsten Franz Knotzel, Maria Norman Hockauf, Lars Beier, Mikael Bauer, Annette Helle Johansen, Lars Lehmann Hylling Christensen, Julie Bille Rannes