Patents Issued in May 12, 2020
-
Patent number: 10647925Abstract: Fuels and/or fuel blending components can be formed from hydroprocessing of high lift deasphalted oil. The high lift deasphalting can correspond to solvent deasphalting to produce a yield of deasphalted oil of at least 50 wt %, or at least 65 wt %, or at least 75 wt %. The resulting fuels and/or fuel blending components formed by hydroprocessing of the deasphalted oil can have unexpectedly high naphthene content and/or density. Additionally or alternately, deasphalted oil generated from high lift deasphalting represents a disadvantaged feed that can be converted into a fuel and/or fuel blending components with unexpected compositions. Additionally or alternately, the resulting fuels and/or fuel blending components can have unexpectedly beneficial cold flow properties, such as cloud point, pour point, and/or freeze point.Type: GrantFiled: December 27, 2016Date of Patent: May 12, 2020Assignee: ExxonMobil Research and Engineering CompanyInventors: Sheryl B. Rubin-Pitel, Kenneth Kar, Kendall S. Fruchey
-
Patent number: 10647926Abstract: An apparatus and process for desulfurization of hydrocarbon feeds is disclosed in which pure nitrous oxide, or a mixture of nitrous oxide and oxygen or air, is used as a gaseous oxidant. Organosulfur compounds are converted to their corresponding oxides sulfones and/or sulfoxides in an oxidation reactor, and oxides are subsequently removed from the oxidation reactor effluent to recover a reduced sulfur-content hydrocarbon product.Type: GrantFiled: December 14, 2011Date of Patent: May 12, 2020Assignee: SAUDI ARABIAN OIL COMPANYInventors: Abdennour Bourane, Omer Refa Koseoglu
-
Patent number: 10647927Abstract: The invention relates to a method of increasing the American Petroleum Institute (API) gravity of feedstocks by reacting one or more mono-cyclic ether solvents such as oxolane with the asphaltene resident in bitumen or crude oils, at an ambient or elevated temperature, and at ambient or elevated pressure, to increase the API gravity and the economic value of the bitumen or crude oil, and a method for in situ manufacturing a mono-cyclic ether, oxolane, to rejuvenate bitumen or heavy crude oils into their younger lighter crude oils by blending methyl linoleate and methanol in a ratio; heating to produce oxolane; and contacting the oxolane as a solvent with the asphaltene resident in bitumen and heavy crude oils to release not only aromatic compounds, represented by toluene, but also the paraffinic alkanes, represented by n-heptane, making the feedstocks ready for extraction, separation of sand, pipeline transport and refining.Type: GrantFiled: July 10, 2019Date of Patent: May 12, 2020Assignee: DPD Chemical Inc.Inventor: Mathew M. Zuckerman
-
Patent number: 10647928Abstract: Methods and systems for converting inactive chemicals into active chemicals in-situ for treating oil and gas pipelines, other industrial systems, or sanitizing surfaces. Also, methods of treating an oil and gas pipeline including feeding an inactive additive through a first conduit and into a second conduit, the second conduit is in fluid communication with the first conduit and the oil and gas pipeline. The inactive additive is converted into an active additive within the second conduit and introduced into the oil and gas pipeline.Type: GrantFiled: November 16, 2018Date of Patent: May 12, 2020Assignee: ECOLAB USA INC.Inventor: Jeremy Moloney
-
Patent number: 10647929Abstract: The present invention relates to a method for converting heavy oil by means of high dispersion of asphaltenes, comprising the steps of: preparing a mixture by mixing an amphiphilic additive and the heavy oil; and performing a hydrogenation reaction on the mixture, wherein the amphiphilic additive comprises both a polar group and a nonpolar group.Type: GrantFiled: March 8, 2017Date of Patent: May 12, 2020Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Chul Wee Lee, Joung Mo Cho, Sun Young Park
-
Patent number: 10647930Abstract: The present invention relates to a hydrocracking reactor system and a process utilizing the same for upgrading heavy hydrocarbonaceous material to value-added products. Accordingly, an aspect of the present invention includes dispersing a liquid feedstock pre-mixed with a catalyst from top of a reactor vessel to obtain dispersed droplets having a predetermined droplet size less than 500 ?m, introducing a gaseous feed comprising primarily of hydrogen from bottom of the reactor vessel to form a continuous gaseous phase throughout a cross-section of the reactor vessel, and allowing the dispersed droplets to contact the continuous gaseous phase throughout the cross-section of the reactor vessel to form reaction effluent comprising one or more lighter product hydrocarbons. The method may further include removing at least a top portion and at least a bottom portion of the reaction effluent from the reactor vessel.Type: GrantFiled: August 30, 2018Date of Patent: May 12, 2020Assignee: INDIAN OIL CORPORATION LIMITEDInventors: Mainak Sarkar, Darshankumar Manubhai Dave, Ramesh Karumanchi, Madhusudan Sau, Ganesh Vitthalrao Butley, Nepal Vishwakarma, Kamal Kumar, Pravesh Kumar, Sarvesh Kumar, Debasis Bhattacharyya, Sanjiv Kumar Mazumdar, Sankara Sri Venkata Ramakumar
-
Patent number: 10647931Abstract: The invention concerns a process for the production of middle distillates, comprising at least one step for the catalytic oligomerization of a feed comprising olefins containing 3 to 9 carbon atoms, in which the reaction section comprises at least two reactors which are positioned in series and which can be permutated, each containing at least one oligomerization catalyst for the oligomerization reactions, said catalysts being identical or different, and in which the reactor which is the furthest downstream in the direction of movement of said feed comprising olefins contains the catalyst with a period of service which is shorter than the period of service of the catalysts present in the other reactors and is operated at an average temperature (WABTn) which is lower than the average temperature (WABTn?1) of the reactor directly preceding it, the difference between said average temperatures being at least 10° C. (WABTn?1?WABTn?10° C.).Type: GrantFiled: November 29, 2016Date of Patent: May 12, 2020Assignee: AXENSInventors: Annick Pucci, Marielle Gagniere
-
Patent number: 10647932Abstract: Process and apparatuses for producing benzene and para-xylene from a reformate stream is provided. The process comprises separating the reformate stream to provide a first stream comprising C4 and lighter hydrocarbons and a second stream comprising aromatic hydrocarbons. The second steam is provided to a reformate splitter to provide a reformate bottoms stream comprising C8+ aromatic hydrocarbons and a reformate overhead stream comprising C7? aromatic hydrocarbons. The reformate overhead stream is passed to an aromatics extraction unit to provide an aromatics extract stream comprising benzene and toluene and a raffinate stream comprising non-aromatic hydrocarbons. The reformate bottoms stream and one of the first stream and the raffinate stream is passed to an olefin reduction zone, wherein the reformate bottoms stream and one of the first stream and the raffinate stream are contacted with an olefin saturation catalyst under olefin saturation conditions to produce an olefin-treated reformate stream.Type: GrantFiled: May 23, 2018Date of Patent: May 12, 2020Assignee: UOP LLCInventors: Jalesh Kalra, Robert J. L. Noe
-
Patent number: 10647933Abstract: Hydropyrolysis processes that accompany the generation of activated carbon as an end product, as well as processes for the production of activated carbon from hydropyrolysis char, are described. Representative processes comprise upgrading, by steam activation, char that is formed from solid biomass-containing feedstocks and/or solid biomass derived feedstocks, such as lignocellulosic feedstocks (e.g., wood). Such processes are associated with a number of advantages in terms of achieving operating synergies, obtaining desirable intermediate material and end product properties, reducing environmental impact, and significantly improving economic attractiveness.Type: GrantFiled: November 12, 2015Date of Patent: May 12, 2020Assignee: Gas Technology InstituteInventors: Terry L. Marker, Martin B. Linck, Michael J. Roberts
-
Patent number: 10647934Abstract: Methods for deriving a low-C hydrocarbon fuel from a platform chemical mixture are provided by introducing the platform chemical mixture to a catalytic material to produce a product stream comprising the low-C hydrocarbon fuel, and separating the low-C hydrocarbon fuel in the product stream from any remaining platform chemicals. Methods for producing aromatic hydrocarbons benzene, toluene, and xylenes from a platform chemical mixture are also provided by introducing a catalytic material to the platform chemical mixture to produce a immiscible liquid product stream comprising BTX, and separating the BTX in the liquid product stream from unreacted platform chemicals via a decanting process.Type: GrantFiled: January 9, 2015Date of Patent: May 12, 2020Assignee: University of South CarolinaInventors: Jochen A. Lauterbach, Sungtak Kim, Erdem Sasmaz, Michael Mayeda
-
Patent number: 10647935Abstract: A process for cleaning and beneficiating biomass is described which may allow removal of entrained salts and light volatiles from biomass materials. The process may also minimize energy use through capturing steam and flue gases for re-use. The process may generally comprise the following steps: prewashing and/or preheating a biomass, pressurizing the biomass in a steam explosion vessel, rapidly depressurizing the steam explosion vessel, releasing the steam from the steam explosion vessel entrained with fine lignin-enriched particles into a cyclone-type gas expansion vessel, routing the steam from the gas expansion vessel to the input hopper, subjecting the biomass to a second washing step, mechanically removing a portion of the water from the biomass. After the biomass has been steam-exploded, it may be washed and used as an engineered soil.Type: GrantFiled: May 18, 2018Date of Patent: May 12, 2020Assignee: ACTIVE ENERGY GROUP PLCInventors: Philip J. Scalzo, Carleton D. Tait, Ronald A. Cella
-
Patent number: 10647936Abstract: A method for improving filterability, while maintaining or improving antifoaming performance, of a lubricating oil in an engine or other mechanical component lubricated with the lubricating oil by using as the lubricating oil a formulated oil. A method for improving antifoaming performance, while maintaining or improving filterability, of a lubricating oil in an engine or other mechanical component lubricated with the lubricating oil by using as the lubricating oil a formulated oil. The formulated oil has a composition including a lubricating oil base stock as a major component, and at least one antifoam agent, as a minor component. A lubricating oil having a composition including a lubricating oil base stock as a major component, and at least one antifoam agent, as a minor component. The antifoam agent is a silicone composition having a highly branched functionalized silicone backbone. The lubricating oils are useful as automotive gear lubricating compositions.Type: GrantFiled: December 19, 2017Date of Patent: May 12, 2020Assignee: ExxonMobil Research and Engineering CompanyInventors: Michael L. Blumenfeld, Angela S. Galiano-Roth, Wenning W. Han
-
Patent number: 10647937Abstract: Provided is a mineral base oil having a kinematic viscosity at 40° C. of 4.0 mm2/s or more and less than 6.0 mm2/s, a kinematic viscosity at 100° C. of 1.0 mm2/s or more and less than 2.0 mm2/s, and a flash point of 140° C. or higher. A lubricating oil composition containing the mineral base oil has a high flash point while having a low viscosity and thus having excellent fuel-saving performance when used as a driving system oil and the like.Type: GrantFiled: February 3, 2017Date of Patent: May 12, 2020Assignee: IDEMITSU KOSAN CO., LTD.Inventors: Norihiro Kuroda, Hisao Anzai, Kenji Goto
-
Patent number: 10647938Abstract: The presently disclosed technology relates to a nano-additives to improve the performance of lubricants, oils, and greases. More specifically, the presently disclosed technology relates to applying capped metal oxide nanoparticles, such as capped zirconia nanoparticles, in the lubricants to produce a tribofilms on the lubricating surfaces to provide wear protection to the said surfaces. Also, the interaction of the capped zirconia nanoparticles with other commonly used additives in lubricants may further optimize the performance of the resulting tribofilms.Type: GrantFiled: May 4, 2016Date of Patent: May 12, 2020Assignees: PIXELLIGENT TECHNOLOGIES, LLC, UCHICAGO ARGONNE, LLC, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Imene Lahouij, Robert Carpick, Andrew Jackson, Harman Khare, Nitya Gosvami, Nicholaos G. Demas, Robert A. Erck, Aaron C. Greco, George R. Fenske, Wei Xu, Gregory Cooper, Zhiyun Chen
-
Patent number: 10647939Abstract: Provided herein are compositions that include a thiadiazole component and a solubility enhancing component. The solubility enhancing component can include a dispersant, a detergent, or both a dispersant and a detergent. The thiadiazole component can include one or more species having a hydrocarbyl-disulfanyl moiety. The compositions may be used as a corrosion inhibitor. Also provided herein are methods for making a thiadiazole component and a composition.Type: GrantFiled: November 18, 2016Date of Patent: May 12, 2020Assignee: International Petroleum Products & Additives Company, Inc.Inventors: Xingguo R. Chen, Jeffrey A. Crow, Troy R. Haynes, Jonathan A. Crow, Brian J. Cereghino
-
Patent number: 10647940Abstract: Provided are a lubricating oil composition containing a base oil and a specific thiophosphate compound (A) and not substantially containing a molybdenum-based, and a precision reduction gear using the lubricating oil composition. The lubricating oil composition and the precision reduction gear using it exhibit excellent wear resistance and can prevent sludge generation in a broad range of contact pressures ranging from high to low.Type: GrantFiled: March 31, 2017Date of Patent: May 12, 2020Assignee: IDEMITSU KOSAN CO., LTD.Inventor: Takuya Ono
-
Patent number: 10647941Abstract: A defoaming agent comprising: a polymer comprising a repeating unit represented by the following general formula (1): where in the general formula (1), X1 is a repeating unit obtainable by polymerization of an ethylenic unsaturated group; Y1 is a side chain comprising a linear or branched polysiloxane structure, the polysiloxane structure comprising a repeating unit represented by the following general formula (2) and having a polymerization degree of 5 to 300; and Z1 is a linking group linking the repeating unit X1 and the side chain Y1; wherein in the general formula (2), R1 and R2 are each independently an organic group having a carbon number of 1 to 18.Type: GrantFiled: August 19, 2016Date of Patent: May 12, 2020Assignee: JXTG NIPPON OIL & ENERGY CORPORATIONInventors: Akira Takagi, Shingo Matsuki
-
Patent number: 10647942Abstract: The present disclosure is directed to the synthesis and application of undecavertol derivatives having unique and desired flavor and/or fragrant characteristics. The compounds of the present disclosure can be employed alone or incorporated as fragrance or flavor ingredients in fragrance or flavor compositions. The present disclosure is also directed to consumer products comprising such derivatives and/or fragrance or flavor compositions.Type: GrantFiled: December 22, 2017Date of Patent: May 12, 2020Assignee: TAKASAGO INTERNATIONAL CORPORATIONInventors: Maureen Blandino, Michael E. Lankin
-
Patent number: 10647943Abstract: Systems and methods are described for forming wax shells for use with electric lighting devices. A template can comprise a sleeve that defines an interior space with a removable core at least partially disposed within the interior space. A modular top can be coupled to the sleeve, depending on the desired upper surface of the wax shell.Type: GrantFiled: April 11, 2016Date of Patent: May 12, 2020Assignee: Luminara Worldwide, LLCInventors: Douglas Patton, James LaBelle, Jeffrey Thompson, Xiaohua Wan
-
Patent number: 10647944Abstract: Cleaning compositions with improved sudsing profiles are provided, which contain a high level of one or more branched and unethoxylated C6-C14 alkyl sulphate anionic surfactants as a primary surfactant, with little or no alkoxylated alkyl sulfate and preferably without any suds suppressors. Such cleaning compositions are particularly suitable for hand-washing dishes or fabrics.Type: GrantFiled: November 8, 2016Date of Patent: May 12, 2020Assignee: The Procter & Gamble CompanyInventors: Ming Tang, Qing Chen, Wenting Liu
-
Patent number: 10647945Abstract: The invention relates to the use of a gel-like polymer composition, which is produced by means of a radical polymerization of an [alpha],[beta]-ethylenically unsaturated acid in the presence of at least one polyether component, in formulations for automatic dishwashing (ADW).Type: GrantFiled: July 2, 2014Date of Patent: May 12, 2020Assignee: BASF SEInventors: Heike Weber, Yannick Fuchs, Helmut Witteler, Roland Boehn, Ralph Rieger
-
Patent number: 10647946Abstract: The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.Type: GrantFiled: May 9, 2016Date of Patent: May 12, 2020Assignee: NOVOZYMES A/SInventors: Carsten Andersen, Chakshusmathi Ghadiyaram, Rajendra Kulothungan Sainathan, Padmavathi Balumuri, Padma Venkatachalam Iyer, Iben Damager, Astrid Munch, Sohel Dalal
-
Patent number: 10647947Abstract: The present invention concerns a detergent comprising a polypeptide having galactanase activity. It further concerns a laundering method and the use of galactanases. The present invention further relates to polypeptides having galactanase activity, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides.Type: GrantFiled: June 4, 2015Date of Patent: May 12, 2020Assignee: Novozymes A/SInventors: Lilian Eva Tang Baltsen, Kirk Matthew Schnorr, Klaus Gori, Lars Kobberoe Skov
-
Patent number: 10647948Abstract: The need for a fast acting and broad spectrum antimicrobial composition which does not reduce surface shine and does not leave visible residues on the surface, while also providing greater residuality of the actives can be met by formulating antimicrobial compositions as described herein.Type: GrantFiled: June 21, 2018Date of Patent: May 12, 2020Assignee: The Procter & Gamble CompanyInventors: Alan Edward Sherry, Molly Pelon Bohlen, Samuel Kimani Njoroge, LaShanda Marie Glenn, Janice Lynn Dhonau, Christopher Todd Morrissey, Jamesina Anne Fitzgerald, Phillip Kyle Vinson, Melinda Phyllis Steffey, Rafael Ortiz, Benjamin Patrick Hale, Yonas Gizaw, Roy Jerome Harrington, Peter Herbert Koenig, Nicola John Policicchio, Stefano Scialla, Steven Daryl Smith, Matthew Scott Wagner
-
Patent number: 10647949Abstract: A cleaning composition for sanitizing and/or disinfecting hard surfaces, comprising: a cationic biocide, surfactant and low levels of VOC solvents. The cleaning composition is adapted to clean a variety of hard surfaces without leaving behind a visible residue and creates low levels of streaking and filming on the treated surface. The cleaning composition contains less than 5% by weight of VOCs. The cleaning composition may be used alone as a liquid or spray formulation or in combination with a substrate, for example, a pre-loaded cleaning wipe.Type: GrantFiled: August 8, 2019Date of Patent: May 12, 2020Assignee: The Clorox CompanyInventors: Diana Mitchell, Sarah Coulter, Ashish Jha, William Ouellette, Gregory van Buskirk
-
Patent number: 10647950Abstract: A composition and method for removing copper-containing post-etch and/or post-ash residue from patterned microelectronic devices is described. The removal composition includes water, a fluoride ion source, an alkanolamine, sulfuric acid, and an organic acid. The compositions effectively remove the copper and cobalt-containing post-etch residue from the microelectronic device without damaging exposed low-k dielectric and metal interconnect materials.Type: GrantFiled: March 31, 2016Date of Patent: May 12, 2020Assignee: VERSUM MATERIALS US, LLCInventors: Seiji Inaoka, William Jack Casteel, Jr., Wen Dar Liu
-
Patent number: 10647951Abstract: The present invention relates to the production of fermented fruit beverages, such as wine and cider, with a reduced level of alcohol. Specifically, the present invention is directed to a method for producing a beverage with a reduced content of alcohol comprising using reverse inoculation or co-inoculation of homofermentative or facultative heterofermentative lactic acid bacterium strain and a yeast strain.Type: GrantFiled: January 21, 2015Date of Patent: May 12, 2020Assignee: CHR. HANSEN A/SInventors: Sofie Saerens, Nathalia Edwards, Kim Ib Soerensen, Mansour Badaki, Jan Hendrik Swiegers
-
Patent number: 10647952Abstract: An all-natural fruit juice, vegetable juice or blend of fruit juice and vegetable juice and alcohol composition, including a mixture of all-natural fruit juice, vegetable juice or blend of fruit juice and vegetable juice and alcohol having a pH of less than or equal to 4.6, wherein the mixture has an alcohol content of 2-20% by volume, and wherein the mixture has been subjected to a high-pressure processing such that the mixture has been subjected to a pressure range of 70,000-95,000 psi for a time period of 1 to 5 minutes.Type: GrantFiled: July 16, 2019Date of Patent: May 12, 2020Inventors: Shawn Lawless, Catherine Ragozzino
-
Patent number: 10647953Abstract: An article suitable for inducing quasispherical cell clustering is provided. The article comprising: a layer suitable for culturing quasispherical cell clusters, the layer comprising a bulk region comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte and at least one predominantly negatively charged positive polyelectrolyte, a back surface region, and a front surface region, wherein the front surface region comprises a net negative fixed surface charge density of between about 0.4 micromole per m2 and about 1.5 micromole per m2.Type: GrantFiled: January 25, 2016Date of Patent: May 12, 2020Assignee: The Florida State University Research Foundation, Inc.Inventors: Joseph B. Schlenoff, Carlos Arias
-
Patent number: 10647954Abstract: A cell culture cartridge is provided comprising a plurality of zones geometrically configured to provide for symmetrical fluid flow with each of the plurality of zones to avoid dead areas in flow within each of the plurality of zones. In certain embodiments, at least eight inlets are provided, with an inlet positioned at each corner of the cell culture cartridge. In certain embodiments, a shared outlet is positioned on a top surface of the cell culture cartridge.Type: GrantFiled: November 15, 2018Date of Patent: May 12, 2020Assignee: FLASKWORKS, LLCInventor: Andrew Kozbial
-
Patent number: 10647955Abstract: An operation isolator forms an aseptic space. An incubator is connected to the operation isolator, in which cells are stored and cultured. A storage chamber stores articles used in the operation isolator. In order to carry articles from the outside into the storage chamber, a decontamination pass-box is provided. The storage chamber and the operation isolator are directly or indirectly connected to each other.Type: GrantFiled: September 18, 2015Date of Patent: May 12, 2020Assignees: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY, BIOMEDICA SOLUTIONS CO., LTD., SHIBUYA CORPORATIONInventors: Hideki Taniguchi, Takanori Takebe, Keisuke Sekine, Atsushi Nakao, Takashi Hiromatsu, Hironobu Sunayama, Tetsuya Nishimura
-
Patent number: 10647956Abstract: The purpose of the present invention is to provide a method for isolating, removing and analyzing cells. Provided is a method for isolating, removing and analyzing cells by filtering a liquid specimen containing cells through a porous polyimide film, and subjecting the cells captured by the film which did not pass through the porous polyimide film, or the cells in the liquid specimen which did pass through the porous polyimide film, to an examination of one or more cell properties selected from a group consisting of cell number or type, internal or external cell structure, type or amount of cell surface antigen, type or amount of material secreted from cells, cell adhesion, and cell survival rate.Type: GrantFiled: January 26, 2016Date of Patent: May 12, 2020Assignees: UBE INDUSTRIES, LTD., UNIVERSITY OF TSUKUBAInventors: Akiyoshi Fukamizu, Jun-Dal Kim, Masahiko Hagihara, Yukinori Wada
-
Patent number: 10647957Abstract: Methods, devices and kits for the physical separation of plankton into its component parts utilizing phototactic behavior are described. The methods utilize positive phototactic behavior and negative contrast orientation of the zooplankton for maximal in situ separation of phytoplankton and zooplankton for use in further studies and evaluation of separation efficiency. The devices provide effective conditions for use in the separation of plankton into component parts.Type: GrantFiled: December 26, 2018Date of Patent: May 12, 2020Inventor: Nancy Leland
-
Patent number: 10647958Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.Type: GrantFiled: November 25, 2019Date of Patent: May 12, 2020Assignee: Inscripta, Inc.Inventors: Phillip Belgrader, Don Masquelier, Bruce Chabansky, Jorge Bernate, Andrew Garst, Richard Fox
-
Patent number: 10647959Abstract: The invention provides polymer scaffolds for cell-based tissue engineering.Type: GrantFiled: April 12, 2012Date of Patent: May 12, 2020Assignee: President and Fellows of Harvard CollegeInventors: David J. Mooney, Jaeyun Kim, Sidi A. Bencherif, Weiwei Aileen Li
-
Patent number: 10647960Abstract: The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.Type: GrantFiled: April 6, 2010Date of Patent: May 12, 2020Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: James Eberwine, Jai-Yoon Sul, Chia-Wen Wu, Fanyi Zeng, Junhyong Kim
-
Patent number: 10647961Abstract: This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.Type: GrantFiled: August 12, 2016Date of Patent: May 12, 2020Assignees: Mayo Foundation for Medical Education and Research, University of WashingtonInventors: Peter A. Cohen, Sandra J. Gendler, Latha B. Pathangey, Dustin B. McCurry, Jessica E. Gorman, Mary L. Disis
-
Patent number: 10647962Abstract: An aluminoborate glass composition, including B2O3, Al2O3, P2O5, Na2O, and CaO, as defined herein. Also disclosed are bioactive compositions including the disclosed aluminoborate glass composition, a suitable fluid, and at least one live cell. Also disclosed is method of limiting the amount of boron released into an aqueous solution from a disclosed aluminoborate-containing glass composition as defined herein. Also disclosed is a method of proliferating cells on a bioactive substrate as defined herein.Type: GrantFiled: May 23, 2017Date of Patent: May 12, 2020Assignee: Corning IncorporatedInventors: Huayun Deng, Ye Fang, Qiang Fu, John Christopher Mauro
-
Patent number: 10647963Abstract: The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to cancer therapies of humans. More specifically, the present invention relates to oncolytic adenoviral vectors alone or together with therapeutic compositions for therapeutic uses and therapeutic methods for cancer. In one aspect the present invention relates to separate administration of adoptive cell therapeutic composition and oncolytic adenoviral vectors. Furthermore, the present invention relates to a pharmaceutical kit and a pharmaceutical composition, both utilizing oncolytic adenoviral vectors.Type: GrantFiled: April 16, 2014Date of Patent: May 12, 2020Assignee: TILT BIOTHERAPEUTICS OYInventors: Akseli Hemminki, Markus Vaha-Koskela, Siri Tahtinen, Vincenzo Cerullo
-
Patent number: 10647964Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.Type: GrantFiled: March 4, 2016Date of Patent: May 12, 2020Assignees: Northwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts CollegeInventors: Gregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
-
Patent number: 10647965Abstract: The present invention relates to a hetero-transglycosylase protein having cellulose:xyloglucan endotransglucosylase (CXE) activity in addition to mixed-linkage beta-glucan:xyloglucan endotransglucosylase (MXE) activity. The protein may comprise the amino acid sequence of any one of SEQ ID NOs: 2, 6 and 8 or a functional fragment thereof; or an amino acid sequence having at least 60% sequence identity to any one of SEQ ID NO: 2, 6 and 8, or to SEQ ID NO: 2 from amino acid 22 to 280, to SEQ ID NO: 6 from amino acid 26 to 283, or to SEQ ID NO: 8 from amino acid 29 to 287. The invention furthermore relates to an isolated nucleic acid encoding the protein described herein, a chimeric gene comprising, inter alia, the nucleic acid described herein, a vector comprising said chimeric gene, a host cell comprising said vector or said chimeric gene and an according transgenic plant. Further disclosed herein in are a method of producing a transgenic plant and a method of improving properties of cellulosic material.Type: GrantFiled: August 31, 2018Date of Patent: May 12, 2020Assignees: BASF SE, THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Frank Meulewaeter, Ilse Van Den Brande, Stephen C. Fry, Kyle E. Mohler, Lenka Frankova, Tom J. Simmons, Claire Holland, Andrew Hudson
-
Patent number: 10647966Abstract: Disclosed are mutant DNA polymerases having increased 3?-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.Type: GrantFiled: January 5, 2018Date of Patent: May 12, 2020Assignee: Roche Molecular Systems, Inc.Inventors: Fred Reichert, Keith Bauer, Thomas W. Myers
-
Patent number: 10647967Abstract: Disclosed are mutant DNA polymerases having increased 3?-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.Type: GrantFiled: January 11, 2018Date of Patent: May 12, 2020Assignee: Roche Molecular Systems, Inc.Inventors: Fred Reichert, Keith Bauer, Thomas W. Myers
-
Patent number: 10647968Abstract: The present invention discloses a new anti-tumor medicament comprising a mutant of endostatin. The mutant comprises a mutation in the ATP-binding site of endostatin and has a decreased ATPase activity and an increased anti-angiogenesis activity.Type: GrantFiled: September 10, 2012Date of Patent: May 12, 2020Assignees: Tsinghua University, Beijing Protgen Ltd.Inventors: Yongzhang Luo, Peng Liu, Xinan Lu, Yang Chen, Yan Fu, Guodong Chang, Daifu Zhou
-
Patent number: 10647969Abstract: The disclosure relates, in general, to Glycogen Storage Disease and, in particular, to a method of treating Glycogen Storage Disease Type IX and to compounds and compositions suitable for use in such a method, including acid alpha-glucosidase.Type: GrantFiled: July 25, 2017Date of Patent: May 12, 2020Assignee: Duke UniversityInventors: Yuan-Tsong Chen, Priya Kishnani, Baodong Sun
-
Patent number: 10647970Abstract: The present invention discloses an L-type amylase variant and use thereof. The ?-amylase variant is obtained by deleting the first N-terminal amino acid residue V from the ?-amylase of B. licheniformis and replacing it with three other amino acid residues DGL. The ?-amylase variant provided by the present invention has high catalytic activity under the acidic conditions of pH 5.0-5.8 and a high temperature of 100° C. or above. The acid resistance and thermal stability of these ?-amylase variants are suitable for starch liquefaction.Type: GrantFiled: May 25, 2018Date of Patent: May 12, 2020Assignee: Nanjing Bestzyme Bio-Engineering Co., LTD.Inventors: Yan Fan, Yan Sun, Hong Xu
-
Patent number: 10647971Abstract: The present invention relates to isolated polypeptides having cellulolytic activity or hemicellulolytic activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: GrantFiled: February 21, 2019Date of Patent: May 12, 2020Assignee: Novozymes A/SInventors: Lene Lange, Peter K. Busk
-
Patent number: 10647972Abstract: The present invention relates to methods for obtaining positive transformants of a filamentous fungal host cell, comprising: transforming a tandem construct into a population of cells of the filamentous fungal host a tandem construct and isolating a transformant of the filamentous fungal host cell comprising the tandem construct. The present invention also relates to such tandem constructs, filamentous fungal host cells comprising such tandem constructs, and methods of producing multiple recombinant proteins.Type: GrantFiled: December 6, 2018Date of Patent: May 12, 2020Assignee: Novozymes, Inc.Inventor: Donna Moyer
-
Patent number: 10647973Abstract: A novel mannanase. A polypeptide having a specific amino acid sequence such as the amino acid represented by SEQ ID NO:2 exhibits a mannanase activity. Although this mannanase does not have homology with known mannanase at the amino acid level, the polypeptide has a mannanase activity as well as heat resistance.Type: GrantFiled: February 29, 2016Date of Patent: May 12, 2020Assignee: MEIJO UNIVERSITY EDUCATIONAL FOUNDATIONInventors: Motoyuki Shimizu, Masashi Kato
-
Patent number: 10647974Abstract: The present invention relates to novel subtilase variants exhibiting increased stability and optionally on par or improved wash performance. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.Type: GrantFiled: June 27, 2014Date of Patent: May 12, 2020Assignee: Novozymes A/SInventors: Jens Erik Nielsen, Pernille Ollendorff Hede, Jurgen Carsten Franz Knotzel, Maria Norman Hockauf, Lars Beier, Mikael Bauer, Annette Helle Johansen, Lars Lehmann Hylling Christensen, Julie Bille Rannes