Abstract: A probe is provided comprising a label and a binding moiety, wherein the binding moiety is adapted to bind to gram-negative bacteria, and to substantially not bind to animal cells or gram-positive bacteria. A method of detecting the presence of bacteria in a target area is also provided, which allows the detection of bacteria generally, and the determination of whether that bacteria is gram negative or gram positive.

Abstract: The disclosure relates to methods for assessing the suitability of a tissue obtained from a vertebrate (e.g., human) donor for grafting to a recipient, such as another vertebrate of the same species. The method involves contacting leukocytes obtained from the donor with serum from the recipient. Binding between recipient antibodies and the leukocytes is assessed, specifically focusing on the subtype(s) of IgG antibodies which bind with donor leukocytes. Detected binding between recipient antibodies of subtypes IgG1 and IgG3 indicates that the donor tissue is not suitable for grafting to the recipient. Detected binding between recipient antibodies of subtypes IgG2 and/or IgG4 indicates that the donor tissue can suitably be grafted to the recipient.

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

Abstract: Provided herein are methods for detecting an Aspergillus protease in a sample, diagnosing a subject with aspergillosis caused by an Aspergillus infection based on the presence of an Aspergillus protease in a sample, and methods of aspergillosis treatment that incorporate these diagnostic methods. In certain embodiments, the Aspergillus protease is Asp f2, and the Aspergillus infection is caused A. fumigatus, A. flavus, A. versicolor, A. niger, or A. terreus. Also provided herein are antibodies and kits for use in these methods, including novel antibodies specific for Asp f2.

Abstract: A method of identifying a subject having cancer who is likely to be responsive to a treatment compound, comprising administering the treatment compound to the subject having the cancer; obtaining a sample from the subject; determining the level of a biomarker in the sample from the subject; and diagnosing the subject as being likely to be responsive to the treatment compound if the level of the biomarker in the sample of the subject changes as compared to a reference level of the biomarker; wherein the treatment compound is a compound of Formula I:

Abstract: The present invention relates to an immunoassay method for the detection of Chromogranin A (or fragment(s) thereof) comprising the steps of contacting a sample suspected of comprising Chromogranin A with a first antibody or an antigen-binding fragment or derivative thereof specific for Chromogranin A and a second antibody or an antigen-binding fragment or derivative thereof specific for Chromogranin A under conditions allowing for the formation of a ternary complex between Chromogranin A and the two antibodies or antigen-binding fragments or derivates thereof, and detecting the binding of the two antibodies or antigen-binding fragments or derivates thereof to Chromogranin A. Also provided are antibodies directed against amino acid residues 124 to 144 and 280 to 301 of Chromogranin A and their use in the immunoassay method.

Abstract: Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations are also provided.

Abstract: A method for identifying a patient that is at risk for developing a thyroid disorder that occurs subsequent to treatment with a regimen that depletes lymphocytes, comprising determining whether antibodies directed against thyroid peroxidase or thyroid microsomes are present in the patient, wherein if the antibodies are present in the patient then the patient is at increased risk for developing a thyroid disorder. A particular embodiment is a method for identifying a patient with multiple sclerosis that is at risk for developing a thyroid disorder that occurs subsequent to treatment with a regimen that depletes CD52-positive cells, comprising determining whether antibodies directed against thyroid peroxidase or thyroid microsomes are present in the patient, wherein if the antibodies are present in the patient then the patient is at risk for developing the thyroid disorder.

Abstract: Methods for detecting a cardiac condition in a human subject are provided according to aspects of the present invention which include providing an immunological reagent characterized by specific binding to: an N-terminal fragment of human cardiac troponin T (HcTnT-N69) or a neoepitope of human cardiac troponin T generated by removal of HcTnT-N69 from HcTnT (HcTnT-neo); contacting the immunological reagent with a biological sample of the human subject under binding conditions; and detecting binding of the immunological reagent with HcTnT-N69 or HcTnT-neo, wherein detection of HcTnT-N69 or HcTnT-neo in the biological sample is indicative of a cardiac condition in the subject. Antibodies and antigen binding fragments thereof characterized by specific binding to HcTnT-N69 or HcTnT-neo, or a variant of either thereof, are provided according to aspects of the present invention.

Abstract: A method for providing information relevant to the diagnosis of a neurodegenerative disorder. The method includes (i) obtaining a biological sample containing vesicles from a subject, (ii) measuring the level of amyloid beta in the biological sample using an antibody specific for the N-terminus of amyloid beta, and (iii) comparing the measured level of amyloid beta in the biological sample with the level of amyloid beta in a previously prepared control sample.

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.

Abstract: Methods, kits and compositions for diagnosing and treating autoimmue diseases such as rheumatiodi arthritis, Crohn's disease, and ulcerative colitis.

Abstract: A method for predicting the level of epicardial adipose tissue (EAT) in a subject comprising: (a) determining a level of one or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from the following: (i) phosphatidylcholine (PC) [16:1/16:1] (ii) diacylglycerol (DAG) [42:8] (iii) phosphatidylethanolamine-ether (PE-O) [32:5] (iv) phosphatidylcholine (PC) [18:0/22:5] (v) phosphatidylinositol (PI) [18:0/16:1] (vi) phosphatidylglycerol (PG) [20:3/20:3] (vii) phosphatidylglycerol (PG) [22:5/18:1] (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of levels of EAT fat in the subject.

Abstract: Methods and compositions related to lipoproteins reactions are provided. Particularly, quantitation of lipoprotein subgroup particle numbers may be used to detect lipoprotein's response to oxidation conditions and incubation conditions. In further aspects, ultracentrifugation may be improved to analyze the lipoprotein profiles. Embodiments are directed to methods for generating a oxidation susceptibility measure for serum lipoproteins. In certain aspects a first portion of a serum sample is used to generate a base lipid particle profile (LPP) and a second portion of the serum sample is used to generate an oxidized lipid particle profile.

Abstract: The invention relates to a laboratory apparatus, and a method, for device-controlled handling of at least one laboratory sample, wherein the laboratory apparatus comprises at least one handling device, wherein the handling is controlled by the laboratory apparatus in use of several program parameters, a control device, a user interface device for manually inputting data by an user, and for the display of information, which may in particular depend on these data, wherein the user interface device comprises a display, on which a display area can be represented, and wherein the user interface device comprises a movement detecting sensor device, which is arranged for the detection of at least one user movement, which can be performed on the display area by an user, and wherein the control device is arranged for the provision of a movement detecting input mode, in order to•select the at least one program parameter and/or define its value depending on the at least one user movement, and•display at least one graphic

Abstract: A device for processing and cataloging of a sample, in a container having a label with identifying data, has a frame; a plurality of cameras mounted to the frame; and a controller system coupled to the cameras, the controller system including a controller and a non-transitory memory storing instructions, which, when executed by the controller, cause carrying out of computer processes that produce a catalog record output characterizing the sample, such record also including the identifying data.

Abstract: Aspects of the present disclosure include systems and methods. According to certain embodiments, provided is an integrated analysis system that includes a first module including a sample analysis component and a first internal container conveyor system. The integrated analysis system further includes a second module including a second internal container conveyor system. The first and second modules are positioned adjacent each other such that the first and second internal container conveyor systems are aligned and adapted to transport containers from the first module to the second module. Also provided are methods of analyzing and preparing samples (e.g., blood and body fluid samples), as well as components that find use within the analysis systems of the present disclosure.

Abstract: A specimen measurement apparatus may include: an aspirator via which a specimen is aspirated. A flow path may be connected to the aspirator. A first pump may be connected to the flow path. A second pump may be connected to the flow path. A controller may select and cause either the first pump or the second pump to aspirate the specimen via the aspirator.

Abstract: A rotation rate detecting apparatus that includes a rotation rate calculating unit configured to calculate a rotation rate of a pedal in a riding apparatus having the pedal rotating by pedaling operation of a user, based on sensor information of an acceleration sensor. The rotation rate calculating unit calculates a rotation rate based on information corresponding to acceleration in a traveling direction of the riding apparatus or a roll direction with respect to the traveling direction in association with movement of the user or the riding apparatus.

Abstract: An inventory management system for automatically generating a restocking order or prompting generation of a restocking order includes a storage space, a divider pivotable on the storage space between an upright position in which the divider separates the storage space into a front storage section and a rear storage section and a recumbent position that facilitates access to the rear storage section; and a motion detector module attached to the divider, the motion detector module including a sensor for detecting pivoting of the divider and a radio frequency transmitter in communication with the accelerometer and configured to emit radio frequency signals when the divider is rotated from the upright position to the recumbent position.

Abstract: Various acceleration sensors are disclosed. In some cases, an inertial mass may be formed during back-end-of-line (BEOL). In other cases, a membrane may have a bent, undulated or winded shape. In yet other embodiments, an inertial mass may span two or more pressure sensing structures.

Abstract: A connection assembly includes a sensor substrate, a layer substrate coupled to the sensor substrate so as to face an upper surface of the sensor substrate, and a wire connected between the sensor substrate and the layer substrate. The sensor substrate includes first and second projections provide on the upper surface of the sensor substrate and extending in an extension direction along the upper surface of the sensor substrate. The wire has a first end sandwiched between the layer substrate and the first projection, and a second end sandwiched between the layer substrate and the second projection. The connection assembly provides reliable connection.

Abstract: A MEMS system includes a proof mass, an anchor, an amplifier, first and second sense elements and their corresponding feedback elements. The proof mass moves responsive to a stimulus. The anchor coupled to the proof mass via a spring. The amplifier receives a proof mass signal from the proof mass and amplifies the signal to generate an output signal. The first sense element is connected between the proof mass and a first input signal and the second sense element is connected between the proof mass and a second input signal. The second input signal has a polarity opposite to the first input signal. The first feedback element is connected between the proof mass and the output signal and its charges change responsive to proof mass displacement. The second feedback element is connected between the proof mass and the output signal and its charges change in response to proof mass displacement.

Abstract: Techniques for self-adjusting calibration of offset and sensitivity of a MEMS accelerometer are provided. In one example, a system comprises a first microelectromechanical (MEMS) sensor. The first MEMS sensor comprises: a proof mass coupled to an anchor connected to a reference plane, wherein the proof mass is coupled to the anchor via a first spring and a second spring; a plurality of reference paddles coupled to the anchor; and a plurality of acceleration sensing electrodes disposed on the reference plane, wherein a first area of each of the acceleration sensing electrodes is larger than a second area of each of a plurality of reference electrodes associated with the plurality of reference paddles.

Abstract: Disclosed herein are devices, systems and methods for in-line, nanoscale metrology. One system comprises monolithic flexure mechanisms with integrated actuators that allow movement and positioning in two axes, with an extremely high degree of accuracy, of a structure comprising one or more scanning probes. This structure is suspended to prevent any destructive interference from a sample, which can be stationary or moving at a nonzero rate, and rigid or flexible in mechanical behavior. This system can be activated at startup and quickly actuate the structure to approach the surface of the sample. Once the system achieves the desired proximity between the one or more probes and the sample, the system maintains that position of the structure to a high degree of accuracy regardless of any disturbances. This array can be moved at varying speeds laterally to match the velocity of any continually moving substrates, thus enabling scanning of moving substrates.

Abstract: A contact terminal may include a tubular body made of an electrically conductive material; and stick-shaped first and second central conductors made of an electrically conductive material. The first and second central conductors may include first and second stick-shaped bodies, first and second clasped portions configured to have a diameter greater than that of each of the first and second stick-shaped bodies, and first and second swell portions configured to have a diameter greater than that of each of the first and second stick-shaped bodies. The first and second central conductors are arranged to have a distal end portion of the first and second swell portions inserted into a joining portion of the tubular body, and to have a distal end surface of the first swell portion and a distal end surface of the second swell portion opposite each other with a gap therebetween.

Abstract: A contact terminal may include an outer tubular body being tubular and conductive and an inner tubular body being tubular and conductive, that is inserted into a cylinder of the outer tubular body. An outer first spring part that is elastic in an axial direction of the outer tubular body and whose winding direction is a first direction to be formed into a helical shape, may be formed on the outer tubular body. An inner first spring part that is elastic in an axial direction of the inner tubular body and whose winding direction is a second direction that is opposite to the first direction to be formed into a helical shape, may be formed on the inner tubular body.

Abstract: Apparatuses, systems, and techniques for characterizing asymmetry effects caused by cathode designs, ESC designs, cable routing, and process chamber geometries are provided. Such apparatuses, systems, and techniques may include, for example, a rotatable RF probe assembly in physical contact to a conductive plate disposed on a surface of a pedestal.

Abstract: The present invention relates to an apparatus and method for securing a box cover to a watthour meter socket box. In certain embodiments, the apparatus has a clamping member that fits over a wall of a meter box, and a lock housing that locks to the clamping member after a box cover has been installed, thereby securing the cover to the box in a manner such that the box cover cannot be installed unless the clamping member has been installed correctly. In various other embodiments, the clamping member consists of a clamp disposed between a clamp actuating member and a fastening shelf. In various other embodiments, the clamp includes a stopping member for indicating when the clamp actuating member is actuated into a fully secured position. Other embodiments relate to a locking bracket and a lock housing wherein the locking bracket generally comprises a clamping member and a fastening lever that attaches to a wall of a meter box base.

Abstract: A signal correction method for correcting a measured signal has the following steps: processing a digital representation of a first signal at a first measurement input; processing a digital representation of a second signal at a second measurement input corresponding to the first signal convoluted with a transfer function; and determining the transfer function for correcting the measured signal. Further, a use of the method, a system for correcting a measured signal, and an oscilloscope are provided.

Abstract: A system and method are provided for a floating reference recloser voltage sensor that measures low energy analog voltage from a voltage divider connected to a high energy transmission line electrode. A floating reference cylindrical voltage screen is coaxially positioned between a high energy transmission line electrode and a cylindrical ground plate, and is positioned closer to the transmission line electrode. The floating reference recloser voltage sensor is filled with a solid dielectric material. A voltage divider network is formed when a voltmeter of a recloser controller is connected to the high-voltage electrode and the floating reference voltage screen, and connected in parallel with another divider network capacitance. The voltmeter reads a low energy voltage drop between the high energy transmission line electrode and the floating reference voltage screen. The recloser controller and the voltmeter are both disconnected from ground.

Abstract: Methods and devices related to current sensing are provided. Magnetoresistive sensor elements are provided on opposite sides of a conductor.

Abstract: A shaft grounding and monitoring system may include a grounding member slidingly engageable with a rotating shaft. An electrical sensor may be configured to be coupled with the grounding member in order to detect an electrical parameter that provides an indication of electricity flowing from the rotating shaft to ground through the grounding member. A processor may be operably coupled with the electrical sensor and may receive and analyze data from the electrical sensor. The processor may be configured to periodically analyze the data representing the electrical parameter from the electrical sensor at a sampling rate and for a sampling period that is related to a rotation speed of the rotating shaft. A memory may be operably coupled with the processor and may be configured to store data processed by the processor that is representative of the data provided by the electrical sensor.

Abstract: A transmission interface module includes a receiving unit, a transmitting unit, a multiplexer, and a processing unit. An output terminal and a control terminal of the receiving unit are electrically connected to the processing unit. The input terminal and the control terminal of the transmitting unit are electrically connected to the processing unit, and the control terminal of the multiplexer is electrically connected to the processing unit. The transmission interface module respectively adjusts a turn-on state or a turn-off state of the analog power terminal, the digital power terminal, the processing unit, the receiving unit, the transmitting unit, and the multiplexer through a plurality of operation modes to transmit the detecting signals.

Abstract: A frequency converter receives a predetermined input signal and a predetermined local oscillation signal, and outputs a signal obtained by mixing the input signal with a harmonic signal having a frequency n times the frequency of the local oscillation signal, wherein a circuit that mixes the input signal with the harmonic signal is a harmonic mixer, which mixes the harmonic signal with the input signal using a nonlinear characteristic of a semiconductor element, and wherein the input signal or the output signal is subjected, either before input to the frequency converter or after output from the frequency converter, to correction on the basis of the amplitude and phase frequency characteristics of the frequency converter, which have been determined in advance.

Abstract: A method measures a frequency characteristic at a feed axis control unit configured to drive a motor in accordance with a velocity command value to control a velocity or a position of a movable portion of a driven body. The velocity command value includes a velocity reference value from a host device or a velocity command calculator and a sweep signal swept in order to measure the frequency characteristic. The method includes moving the feed axis in one direction by commanding the velocity reference value where a moving velocity of the feed axis is constant, exciting by providing a sine wave having an amplitude less than a magnitude of the velocity reference value to the sweep signal, and measuring the frequency characteristic of a feed axis drive system including the motor.

Abstract: A method may include applying an excitation signal to a capacitor of the capacitive sensor which causes generation of a modulated signal from an input signal indicative of a variance in a capacitance of the capacitor, detecting the modulated signal with a detector to generate a detected modulated signal that has a phase shift relative to the excitation signal, demodulating the detected modulated signal into an in-phase component and a quadrature component using a reference signal, nullifying the quadrature component by setting a phase of the reference signal relative to the excitation signal to compensate for the phase shift, and outputting the in-phase component as an unmodulated output signal representative of the capacitance.

Abstract: A probe is provided for measuring permittivity of a dielectric material. The probe includes side electrodes and a pivotable center electrode with a bulbous tip to contact the material. A mounting harness supports the side electrodes and a feed connector with the center electrode soldered to the connector. The tip includes a contoured surface for measurement and rotation on the material. The bulbous tip can rest perpendicularly or in a pivoted position on the material without a loss of measurement accuracy. A saddle ensures that a measurement of the reflection coefficient is near the bulbous tip. In use, a voltage wave generated by a vector network analyzer is guided between the electrodes toward the tip and into the material. The material reflects this voltage wave back to the analyzer. The ratio of the reflected and forward voltages forms a reflection coefficient as a baseline for measuring permittivity.

Abstract: An electronic device may include a shaft insertable into a target area, and an electronic component configured to generate a signal. The electronic component may be on or within the shaft. The electronic device may also include at least one antenna on or within the shaft. The electronic device may also include a receiver operatively coupled to the antenna. The receiver may monitor an electrical characteristic of the antenna to identify an effect of an electromagnetic field on the electrical characteristic of the antenna. The electronic device may also include a processor communicatively coupled to the receiver. At least one of the receiver and the processor may predict an effect of the electromagnetic field on the signal generated by the electronic component, based at least in part on the effect of the electromagnetic field on the electrical characteristic of the antenna.

Abstract: A method to generate data to geolocate lightning pulses may include detecting in an environment EMF generated from the lightning pulses. The method may include producing lightning-EMF from the detected EMF where the lightning-EMF may represent the EMF generated from the lightning pulses. The method may include extracting a lightning-waveform-feature set from the lightning-EMF data, including extracting one or more waveform features for each of the lightning pulses from the lightning-EMF data. The method may also include transmitting the extracted lightning-waveform-feature set to a server to perform time alignment on multiple extracted lightning-waveform-feature sets received from multiple lightning-detection sensors and to geolocate the lightning pulses based on the time-aligned extracted lightning-waveform-feature sets.

Abstract: A system and a method for determining local electric field strengths, the system including: a light source module configured to emit light; a plurality of electric field sensors, each sensor including a light input portion and a light output portion, each sensor including an electro-optic material arranged in a path of at least some of the received light, an optical property of the electro-optic material being variable depending on a local electric field strength at the sensor, and the electro-optic material being arranged in the sensor such that a property of the output light varies depending on the local electric field strength; a light detection module arranged to receive the output light from the sensors; and a processing module in communication with the light detection module, the processing module being programmed to determine a corresponding value for the electric field strength local to each of the sensors.

Abstract: A conductor-mounted device (CMD) used to signal an intelligent electronic device (IED) of the existence of a fault on a portion of the electric power delivery system is described herein. The CMD may provide a heartbeat signal to the IED. The CMD may provide a fault signal to the IED. The CMD may be powered via a parasitic current draw on the conductor to which it is mounted. An IED may use a fault signal and/or LOC signal from a CMD to coordinate a high-impedance fault detection and/or downed line events.

Abstract: A power transistor, a driver and an output stage. The power transistor includes an active region and a metallization level located above the active region for power distribution and for detecting an imminent metallization error induced by stress (RPP stress) caused by repeated power pulses. The power transistor also includes a further metallization level, which is located above the metallization level and in which galvanically isolated metal elements extend mutually parallel in a direction of extent, of which one pair is used for energizing the power transistor. It is a characteristic of the power transistor that at least one cut-out is formed above the active region in the further metallization level. The cut-out has the effect of decreasing heat dissipation. The power transistor is thereby heated more intensely in the localized region, so that large temperature gradients occur in the transition region defined by the edges of the metal elements.

Abstract: A tester apparatus is described. Various components contribute to the functionality of the tester apparatus, including an insertion and removal apparatus, thermal posts, independent gimbaling, the inclusion of a photo detector, a combination of thermal control methods, a detect circuitry in a socket lid, through posts with stand-offs, and a voltage retargeting.

Abstract: A radio test system for testing a device under test is described, comprising a signal generation unit configured to generate a downlink signal to be transmitted to the device under test for over-the-air testing. The radio test system has at least one antenna configured to transmit the downlink signal via an over-the-air transmission channel to the device under test. Further, a receiver is provided that is configured to receive a response signal via the over-the-air transmission channel from the device under test. In addition, the radio test system has at least one over-the-air adapter that is connected to the signal generation unit wherein the over-the-air adapter is configured to adapt the downlink signal to be transmitted such that the over-the-air transmission channel is equalized. Further, a method for testing a device under test is described.

Abstract: A drag-and-drop workflow editor in an Automated Test Equipment (ATE) environment to create coherent time domain aligned test programs. This includes graphical interface channel diagrams with channel headers, channel timelines, designer items defining test operations, measurement references and trigger references to define temporal relationships in a time domain environment.

Abstract: A byte lane of an integrated circuit including two data strobe loopback paths that allow external test signals to flow in and out of the integrated circuit through data strobe pins in two opposite directions. The integrated circuit includes a Feed Forward Equalization (FFE) path configured to send FFE signals output from the FFE logic via a transmitter set to a first data strobe interface during a normal operation. In a loopback test mode operation, a test signal can be supplied from a second data strobe interface and output to the first data strobe interface by reusing the FFE path. The second loopback path conversely allows a test signal to be routed from the first data strobe interface to the second.

Abstract: A method in which connectivity tests of integrated circuit structures in a die are performed. The connectivity tests are performed at a first level of the die. Potential defect locations are identified in the die indicating via locations susceptible to systematic failure due to via opens or via shorts. The potential defect locations are translated to via locations for a second level of the die. The second level is below the first level. After translating the hot spot, the second level is inspected for defects. The via locations on the first level are inspected for defects. All defects for the second level are translated to the via locations for the first level. A net trace of defects is created using prior level subtraction of the translated defects for the second level and the defects for the first level.

Abstract: A semiconductor device including a test circuit is disclosed. The semiconductor device includes a test pad coupled to a probe of a test device during a wafer test; a normal pad configured to receive a power or a signal during a normal mode; and a test circuit configured to perform a predetermined test operation based on a test signal received through the test pad. The test circuit is disposed below the normal pad.

Abstract: Aspects include a method for logic built-in self-testing (LBIST) for use in an integrated circuit with scan chains. The method includes programming a product control generator and a pattern generator with an LBIST pattern comprising at least a number of loops. The LBIST pattern is executed by generating scan-in test values for scan chains with the pattern generator and controlling at least one test parameter with the product control generator. Scan-out responses are collected from the scan chains in a signature register, and a start request is received from a chip tester. The LBIST is started in response to the start request. Test summary data is reported to the chip tester before the whole number of loops has been executed.