Abstract: An apparatus includes a housing, a carrier, and an expandable assembly. The housing defines an opening configured to selectively place a gas chamber of the housing in fluid communication with an exterior volume. The carrier is movably disposed within the housing and is coupled to a medicament container. A proximal surface of the carrier defines a portion of a boundary of the gas chamber. The expandable assembly has a first member and a second member. The first member is coupled to an elastomeric member disposed within the medicament container, and the second member includes a valve portion. The expandable assembly transitions from a collapsed configuration to an expanded configuration when the elastomeric member moves within the medicament container. The valve portion moves relative to the opening when the expandable assembly transitions from the first to the second configuration, placing the gas chamber in fluid communication with the exterior volume.

Abstract: An apparatus and method for adjusting an injection device for administering a substance that includes a device housing with an array of fastening points. The apparatus has at least two housing-like shells, each having at least one holding device and at least one blocking device for attaching to the housing. The holding device of a first shell can be attached to a fastening point, and the holding device of a second shell can be attached to a further fastening point. Upon attaching all of the plurality of housing-like shells to the housing, the blocking devices of the plurality of housing-like shells prevent the disengagement of the plurality of housing-like shells from the housing by blocking detachment of the holding devices from the fastening points. At least one of the housing-like shells comprises an electronic assembly and shell attachment to the housing activates the electronic assembly.

Abstract: A data collection device for attachment to an injection device, such as an injector pen, includes a sensor arrangement to detect movement of a movable component of the injection device relative to the data collection device during delivery of a medicament by the injection device, and a processor arrangement configured to, based on said detected movement, determine a medicament dosage administered by the injection device. The processor arrangement may monitor the time that has elapsed since the medicament dosage was administered, and control a display to show the mediacament dosage and elapsed time to provide a memory aid to the user. In an example embodiment, the sensor arrangement includes an optical encoder and the movable component includes a plurality of light barrier formations. The movable component may be a number sleeve that provides a visual indication of a dose programmed into the injection device.

Abstract: A drug delivery device is provided comprising a drug-filled cartridge or means for receiving a drug-filled cartridge, and drug expelling means comprising expelling means for expelling an amount of drug from the cartridge, and an indicator member arranged to move corresponding to an action performed on or by the drug delivery device. The device further comprises an energy source, wireless communication means, sensor means adapted to detect movement of the indicator member, and a processor adapted to (i) receive input from the drug delivery device indicative of indicator member movement and (ii) control the communication means to transmit a data signal comprising coded information derived from received input from the sensor means, wherein the wireless communication means is in the form of a sound transducer.

Abstract: The present disclosure relates to a medicament delivery device comprising: a housing, a plunger rod received by the housing, which plunger rod is rotatable in a first direction relative to the housing and linearly displaceable, an activation button arrangement linearly displaceable from a first position to a second position to thereby rotate the plunger rod in the first direction, a second direction rotation preventer having an annular outer member that is rotationally fixed relative to the housing and an annular inner member partially received by the outer member, wherein the outer member and the inner member are arranged to receive the plunger rod and wherein the inner member is rotationally interlocked with the plunger rod, wherein the outer member and the inner member are structured to allow the inner member to rotate in the first direction relative to the outer member and to prevent the inner member from rotating in a second direction opposite to the first direction, and a recording unit comprising: a fi

Abstract: An injection device includes a housing for receiving a syringe or cartridge for containing a medicament; a rotary driveshaft mounted for rotation relative to the housing; and an elongate coiled torsion spring having respective formations at opposite ends thereof, with a first formation being anchored in a seat on the rotary drive shaft and a second formation being anchored in a seat on a reaction component. In use relative rotation of the rotary driveshaft and the reaction component in one angular direction strains the torsion drive spring, and release of the strained torsion drive spring causes expression of medicament from the syringe or cartridge. The torsion spring is longitudinally resiliently compressible between its end formations whereby during assembly of the injection device, the torsion spring may be longitudinally compressed and then rotated, thereby urging the end formations of the torsion drive spring into engagement with the respective seats.

Abstract: An administration assembly is presented having a plunger rod, a first resilient member biasing the plunger rod, an elongated plunger rod holder configured to receive the plunger rod, an activation sleeve receiving a portion of the plunger rod holder, and configured to move axially from a first position relative to the plunger rod holder to a second position. The activation sleeve is biased towards the first position and the plunger rod holder has a first hold and release structure and the plunger rod has a second hold and release structure, wherein in the first position the activation sleeve is configured to maintain the first hold and release structure in an axially locking contact position with the second hold and release structure in which the second hold and release structure is prevented from movement relative to the first hold and release structure, thereby locking the plunger rod axially relative to the plunger rod holder.

Abstract: A drug solution administration device includes a drug solution reservoir, a drive unit, a rotation detection unit, and a control unit. The control unit counts the number of rotations of the drive unit from when a rotation sensor value reaches a blockage start threshold value until the rotation sensor value reaches a blockage detection threshold value. Further, the control unit determines that a blockage of a flow path has occurred when the rotation sensor value reaches the blockage detection threshold value, and rotates the drive unit in a direction opposite to a direction in which the drug solution is administered based on the counted number of rotations.

Abstract: A disposable syringe for use with a pneumatic driver. The syringe has an elongated barrel with a cap secured to the proximal end that has a through bore. A filter is secured to the cap interior of the barrel that covers an opening in the through bore interior of the barrel. The pneumatic driver includes a source of pressurized air; a support for receiving and locating the syringe; and a supply block configured to receive pressurized air from the source and having an outlet for delivery of pressurized air. The supply block is movable between a first position spaced apart from the cap of the syringe and a second position in contact with the cap with fluid communication being established between the outlet of the supply block and the through-bore in the cap.

Abstract: A needle actuator assembly for a drug delivery system includes a needle actuator body having a guide surface, a needle shuttle having a cam surface, with the needle shuttle moveable along a vertical axis between a first position and a second position. The needle shuttle is configured to move between the first and second position through engagement between the guide surface of the needle actuator body and the cam surface of the needle shuttle. The assembly further including a needle received by the needle shuttle.

Abstract: An accessory for an injection device having a needle cap. The accessory comprises a body portion comprising a recess adapted to receive the injection device and a cover coupled to the body portion. The cover is pivotally moveable between an open position in which the recess is exposed to receive the injection device, and a closed position in which the cover at least partially closes the recess to hold the injection device in the body portion. The accessory further comprises a cap remover comprising a grip adapted to hold the needle cap. The cap remover is moveable with respect to the body portion.

Abstract: An accessory for an injection device having a needle cap. The accessory comprises a body portion comprising a recess adapted to receive the injection device and a cover coupled to the body portion. The cover is pivotally moveable between an open position in which the recess is exposed to receive the injection device, and a closed position in which the cover at least partially closes the recess to hold the injection device in the body portion. The accessory further comprises a cap remover comprising a grip, the cap remover having an expanded configuration in which the needle cap can pass between the grip, and a constricted configuration in which the grip holds the needle cap to at least partially remove the needle cap from the injection device.

Abstract: An accessory for an injection device having a safety shield and at least one flange adapted to allow a user to grip the injection device and a syringe sheath moveable relative to the at least one flange from a pre-injection position to a locked-out position. The accessory comprises a body portion comprising a recess adapted to receive the safety shield of the injection device and a slot adapted to receive the at least one flange of the injection device.

Abstract: An accessory for an injection device having a needle cap. The accessory comprises a body portion comprising a recess adapted to receive the injection device and a cover coupled to the body portion. The cover is pivotally moveable between an open position and a closed position. The accessory further comprises a cap remover comprising a grip adapted to hold the needle cap. The body portion comprises a track within which the cap remover is arranged to move axially with respect to the body portion. The track is adapted such that when the injection device is located in the body portion the cap remover is held against the track by the injection device.

Abstract: An autoinjector apparatus is disclosed which comprises a single-use cassette and an autoinjector. The cassette comprises a housing and a sleeve movably disposed in the housing. A syringe may be disposed in the sleeve and secured therein with a lock cap. The lock cap is affixed to a distal end of the sleeve and contacts the distal end of the syringe. A shield remover extends through an opening in a proximal end of the housing for removing a needle shield which covers a needle of the syringe. A cassette identification arrangement is provided on a surface of the housing to enable the autoinjector to identify the cassette. The autoinjector is provided with a detector for reading the cassette identification arrangement.

Abstract: Implants are placed in turbinate mucosal tissue using a surgical device having a proximal grip portion and a distal hollow sharp needle portion that is manipulated using the grip portion and inserted submucosally into mucosal turbinate tissue. One or more biodegradable, drug-eluting solid implants are disposed within the needle. The implants have one or more implant withdrawal-discouraging, mucosal tissue-engaging surface features along their length. An actuator disposed within the device is used to deliver one or more of the implants from the needle into the mucosal turbinate tissue and submucosally bury at least one such tissue-engaging feature therein.

Abstract: A syringe assembly for a drug delivery device. The syringe assembly includes a syringe barrel having a proximal end, a distal end, and a longitudinal axis. A needle assembly is operatively coupled to the syringe barrel and includes a needle hub and a needle attached to the needle hub. A flexible connection is disposed between the syringe barrel and the needle hub and forms a fluid pathway between the syringe barrel and the needle. The flexible connection enables the needle assembly to be moveable from a filling position, in which a longitudinal axis of the needle assembly is parallel to a longitudinal axis of the syringe barrel, to an assembled position, in which the longitudinal axis of the needle assembly is not parallel to the longitudinal axis of the syringe barrel.

Abstract: An adjustable misting system and method for treating a region of a biological surface is presented. In an embodiment, a reconfigurable misting nebulizer includes a first misting panel having a plurality of apertures configured to atomize a formulation, and a second misting panel coupled to the first misting panel having a plurality of apertures configured to atomize the formulation. In some embodiments, a relative position of the first misting panel with respect to the second misting panel is adjustable.

Abstract: A dispenser device for fluid or powder, including an air expeller (20) and a reservoir (30). The reservoir (30) has an air inlet (31) connected to the air expeller (20) and a composition outlet (32) connected to a dispenser opening (10), and is removably mounted on the air expeller. After actuation, the empty reservoir can be removed from the air expeller and replaced with a new reservoir. The air inlet (31) is closed by a first closure element (40) and the composition outlet (32) is closed by a second closure element (50). A mechanical opening system (61, 62) co-operates with the first and second closure elements to expel each closure element from the closed position. The mechanical opening system has a first rod (61) secured to the air expeller (20), and a second rod (62) secured to the dispenser head (1), co-operating with a closure element during actuation.

Abstract: Self-puncturing liquid drug cartridges and an associated inhaler are used to deliver one or more separate doses of an aerosolized liquid drug. A cartridge includes a needle assembly coupled to a drug container. The needle assembly includes a hollow needle and is reconfigurable from a first configuration to a second configuration upon insertion of the cartridge into the inhaler. In the first configuration, the hollow needle does not extend into the container. In the second configuration, the hollow needle extends into the container. The inhaler includes an aerosol generator that includes a vibratable membrane that aerosolizes liquid drug ejected from the cartridge for inhalation by a patient.

Abstract: The present invention provides a device for delivering a predetermined volume of a substance, within at least one body cavity of a subject, comprising a predefined volume for containing the predetermined volume of the at least one substance; a delivery end for placement in proximity to the body cavity; the delivery end comprises at least one orifice of diameter D [mm]; a valve mechanically connectable to the container, characterized by at least two configurations: (i) an active configuration in which the valve enables delivery of predetermined amount Msub of the substance; and, (ii) an inactive configuration, in which the valve prevents delivery of the predetermined amount Msub of the substance from the container to the body cavity; and a fluid tight chamber configured to contain predetermined volume Vgas of pressurized gas at a predetermined pressure, Pgas.

Abstract: The present invention provides methods and a BFS/FFS system for delivering either one or more substances within at least one body cavity, characterized by a vial comprising Vsub [ml] of said substances; said vail selected from a pierceable container, a blow-fill-seal and a form-fill-seal, having fluid inlet and a fluid discharging outlet of diameter D [mm], configured for placement in proximity to said body cavity; said fluid inlet configured by means of size and shape to interface in a sealable manner a puncturing member, configured to, upon coupling to said fluid inlet, piercing the same, thereby providing said substances in a fluid communication, via a valve, with a chamber configured to accept pressurized fluid at volume VPF [ml] and pressure PPF [barg]; said valve is commutable from an CLOSE to an OPEN CONFIGURATION within a short period of time, <500 milliseconds (dT); at said OPEN CONFIGURATION, said pressurized fluid flows from said chamber, via said fluid inlet, entrains said substances by one of

Abstract: To provide a control device for an aerosol inhalator capable of compensating changes in temperature of a heater due to inhalation. A control device for an aerosol inhalator includes a first sensor for obtaining a first value relating to a temperature of a load which atomizes an aerosol source stored in a reservoir or retained by an aerosol base using heat generated by supply of electric power, a second sensor configured to detect an inhalation, and a controller, wherein the controller is configured to determine, based on a second value based on the first value and a threshold, whether the aerosol source in the reservoir or the aerosol base is depleted or insufficient (850A), and correct at least one of the second value and the threshold when detecting the inhalation (840) and, in the determination, compare the second value and the threshold, at least one of the second value and the threshold being corrected (842).

Abstract: A drug receptacle for use with a respiratory inhaler device. The drug receptacle has a fluid flow rate indicator on an outer surface thereof. The fluid flow rate indicator comprises a corrugated portion having at least one and preferably a plurality of corrugations extending radially from the outer surface of the drug receptacle. The flow rate indicator is operable to generate a sound signal. The present invention also relates to a corrugated flow rate indicator having a connection portion for connection to the outer surface of a drug receptacle.

Abstract: An aerosolization apparatus comprises a housing defining a chamber having one or more air inlets. The chamber is sized to receive a capsule which contains an aerosolizable pharmaceutical formulation. The aerosolization apparatus further comprises a puncturing mechanism within the housing. The puncturing mechanism comprises an alignment guide and a puncture member, wherein the alignment guide comprises a surface adapted to contact the capsule while the puncture member is advanced into the capsule to create an opening in the capsule. At least a portion of the surface is sloped relative to the longitudinal axis of the capsule. Alternatively or additionally, the surface may comprise one or more protrusions. An end section is associated with the housing. The end section is sized and shaped to be received in a user's mouth or nose so that the user may inhale through the end section to inhale aerosolized pharmaceutical formulation that has exited the capsule through the opening created in the capsule.

Abstract: An inhaler article includes a tubular housing defining a holder body extending along a longitudinal axis from a mouthpiece end to a consumable receiving end. The holder body includes an inner tube extending along the longitudinal axis and within the tubular housing from a tube intake end to a tube exhaust end. The tube intake end is proximate the consumable receiving end. The inner tube defines an air flow lumen with two or more air flow apertures extending through a wall of the inner tube. An air blocking feature is positioned in the air flow lumen and between two of the air flow apertures. A vibration inducing element disposed on the inner tube proximate to the tube exhaust end or the tube intake end, the vibration inducing element comprises an aperture through the wall of the inner tube and having a tapered or angled downstream aperture edge.

Abstract: The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device having improved flow characteristics.

Abstract: A pharmaceutical composition and administration apparatus includes a portable powered vaporizer with a mouthpiece, smokeless vaporizing element, and a removable chamber. The chamber contains a composition comprising tetrahydrocannabinol (THC), cannabidiol (CBD), FCC grade ethanol, flavoring, pharmaceutical grade nicotine, USP grade aqueous glycerine, USP/EP grade propylene glycol, and USP grade vegetable glycerine. In various formulas the THC may be at concentrations of 1-30%, 30-60% and 60-99%, while CBD concentrations may be 0-15% including other cannabinoids derived from extraction.

Abstract: A respiratory flow limitation detection device, which can include an airway pressure treatment generator, determines a flow limitation measure 506 based one or more shape indices for detecting partial obstruction and a measure of a patient's ventilation or respiratory duty cycle. The shape indices may be based on function(s) that ascertain the likelihood of the presence of M-shaped breathing patterns and/or chair-shaped breathing patterns. The measure of ventilation may be based on analysis of current and prior tidal volumes to detect a less than normal patient ventilation. The duty cycle measure may be a ratio of current and prior measures of inspiratory time to respiratory cycle time to detect an increase in the patient's inspiratory cycle time relative to the respiratory cycle time. A pressure setting based on the flow limitation may then be used to adjust the treatment pressure to ameliorate the patient's detected flow limitation condition.

Abstract: Systems and methods of control of a mechanical ventilator include receiving machine data from a mechanical ventilator. A surgical event is detected in the received machine data. Clinical events within the surgical event are detected in the machine data. The machine data and the detected plurality of clinical events are evaluated for compliance with lung protective ventilation recommendations.

Abstract: A pressure support system (2) for providing pressure support therapy to a patient. The pressure support system includes an airflow generator (6) structured to generate a flow of breathing gas to the patient, a number of sensors (22,27) structured to sense characteristics of breaths of the patient, and a processing unit (24) structured to calculate a number of breath features of the patient based on the characteristics of breaths of the patient, to calculate a comfort level based on one or more of the calculated number of breath features, and to adjust a gain of the airflow generator based on the calculated comfort level.

Abstract: This disclosure provides an endotracheal tube with a tip suitable for traversing the laryngeal inlet and with a guiding channel having a proximal opening adjacent a proximal end portion and a distal opening adjacent to a tip, wherein the guiding channel is adjacent a sidewall of the main lumen of the tube, which allows more accurate wire-guided intubation of a patient, a method and a kit relating to the same.

Abstract: A nasal cannula for use in a system for providing a flow of respiratory gases to a user is described. The nasal cannula comprises a body made from a pliable material. The body has an inlet and at least one nasal prong fluidly connected to the inlet. In use a conduit providing a flow of gases to the cannula is connected to the inlet, and the nasal prong is inserted into a user's nostril. The cannula is arranged to direct the flow of gases from the nasal prong towards the front wall of the user's nasal passage within the user's nose.

Abstract: A cushion member is for a patient interface device. The cushion member includes a body portion, a patient contacting portion, and a pre-stressed element located in at least one of the body portion or the patient contacting portion.

Abstract: A sealing arrangement for use in delivering a flow of breathing gas to an airway of a patient includes a base structure having a surface positioned to engage the face of the patient. The base structure defines an opening having a perimeter which is sized and configured to be disposed about one or more of the mouth and/or nares of the patient. The sealing arrangement further includes a secondary element coupled to the base structure. The secondary element is positioned and structured to contact the face of the patient when the base structure is disposed with the perimeter about the one or more of the mouth and/or nares of the patient. The base structure is formed from a first material, and the secondary element is formed from a second material different than the first material.

Abstract: Apparatus and methods are provided for delivery of a medicament to a respiratory system. A reservoir is provided for a liquid medicament with the reservoir having a liquid medicament inlet port and a medicament outlet. An aerosol generator is provided at the medicament outlet of the reservoir for aerosolizing the liquid medicament. A connector entrains the aerosolized medicament from the aerosol generator with a gas.

Abstract: The invention relates to providing novel functions to the coaxial breathing circuits which at present do not comprise water traps, by adding a closed system water trap designed to have an inkwell shape and a lung pressure measurement port to said circuits wherein the fluid collected in the bottle section can be discharged without having to open the bottle by means of a drainage luer port located at the base of the bottle and a needleless apparatus that has been inserted into the port, and an injector.

Abstract: A patient interface device includes a frame having a central portion with a patient facing side, an opposite outward facing side, a first plurality of magnetic elements secured on or in the patient facing side, and a first aperture defined therethrough. The first aperture having a first portion extending from the outward facing side toward the patient facing side which is structured to be coupled to a delivery conduit and a patient side portion defined by a wall which extends outward from the patient facing side forming a hub. The device further includes a cushion having a patient contacting side which is structured to sealingly engage about an orifice or orifices of a patient, an opposite frame contacting side including a second aperture defined therein which is sized and configured to engage about the hub, and a second plurality of magnetic elements for magnetically coupling the cushion to the frame.

Abstract: A patient interface device for use in delivering a flow of a breathing gas to the airway of a patient includes a frame formed of a substantially rigid material and a flexible airway formed of a pliable material. The flexible airway includes: a first end having an aperture defined therein which is structured to be coupled to a gas delivery conduit for receiving the flow of breathing gas; a second end disposed opposite the first end and coupled to the frame, the second end having a sealing flap extending radially inward from a periphery of the second end which is structured to sealingly engage the face of the patient about the airway of the patient; and a wall portion extending between the first end and the second end, the wall portion defining a passage adapted to convey the flow of breathing gas from the first end to the second end.

Abstract: The present invention relates to oxygen sensors for medical ventilators. A medical ventilator includes a patient circuit delivering inspiratory airflow to a patient and returning expiratory airflow from the patient back to the ventilator. A manifold includes an air flow path into the patient circuit, and a port with an opening for an oxygen sensor. When mated to the port, the oxygen sensor samples the air in the air flow path and detects the amount of oxygen in the air. When the oxygen sensor is inserted into the port, a valve is biased open, to allow airflow through the opening into the oxygen sensor during ventilation. When the oxygen sensor is removed from the port, the valve biases into a closed position covering the opening, to prevent leaks. The ventilator can then continue to operate without the oxygen sensor in place.

Abstract: The present disclosure pertains to a system and method for facilitating pressure support therapy, mechanical inexsufflation therapy, and suctioning therapy for a subject. The system and method described herein offer a novel combination of mechanical inexsufflation with suctioning from a vacuum system. The invasive nature of current closed suctioning systems poses many potential risks, such as tissue trauma, less optimum secretion clearance at the peripheral airway, and lung decruitment. The system and method described herein provide a non-invasive method of suctioning with a suctioning volume measurement and a monitoring alarm to ensure a baseline lung volume and a positive end expiratory pressure (PEEP) level are maintained. This non-invasive method of suctioning is provided together with mechanical inexsufflation and pressure support therapy.

Abstract: A mobile pain management device for managing pain of a patient, the device includes a nerve block engageable with a first nerve of the patient and an electrical stimulation device engageable with a second nerve of the patient. The device includes an analgesic dispensing system having analgesic solution stored therein, the analgesic dispensing system connected to the nerve block such that when the nerve block is activated, the dispensing system provides at least a portion of the analgesic solution to the nerve block. The device includes a control module, in response to executable instructions, providing pain relieve the patient through engagement of the nerve block and the electrical stimulation. And the device includes a sensor detecting feedback from the patient such that the control module modifies the providing of pain relief to the patient based on the feedback.

Abstract: A mask includes a body having an interior surface defining a cavity shaped to receive a user's nose. An exterior surface of the body is exposed to an ambient environment. The body includes an inlet in fluid communication with the cavity and a one-way exhaust valve in fluid communication between the cavity and the ambient environment. A therapeutic substance dispenser is in fluid communication with the cavity. In one embodiment, a nasal aromatic decongestant is disposed in the therapeutic dispenser. A mask includes an upper nasal cavity separate from a lower oral cavity, with an inlet in fluid communication with only the upper nasal cavity. A medicament delivery assembly, and methods for the use thereof, are also provided.

Abstract: The present disclosure pertains to a system and method for providing mandibular advancement and sleep positional therapy to a user for a sleep session. The system is formed by a mandibular advancement device for treating obstructive sleep disordered breathing (e.g., obstructive sleep apnea and snoring) that includes an electronics module configured to aid in sleep positional training. The present system and method facilitate advancing a lower jaw of the user into a protruding position relative to an upper jaw of the user to increase a size of an airway of the user, determining whether a posture of the user has breached a posture threshold, and, responsive to a breach, prompting the user to change posture such that the posture of the user no longer breaches the posture threshold.

Abstract: The present disclosure pertains to a system and method for automatically detecting rapid eye movement (REM) sleep and delivering sensory stimulation to prolong REM duration, without disturbing sleep. The sensory stimulation may be auditory or other stimulation. The system and method ensure timely delivery of the stimulation and automatically adjust the amount, intensity, and/or timing of stimulation as necessary. REM sleep is detected based brain activity, cardiac activity and/or other information. REM sleep may be detected and/or predicted by a trained neural network. The amount, timing, and/or intensity of the sensory stimulation may be determined and/or modulated to enhance REM sleep in a subject based on one or more values of one or more intermediate layers of the neural network and one or more brain activity and/or cardiac activity parameters.

Abstract: A method of providing repetitive motion therapy comprising providing access to audio content; selecting audio content for delivery to a patient; performing an analysis on the selected audio content, the analysis identifying audio features of the selected audio content, and extracting rhythmic and structural features of the selected audio content; performing an entrainment suitability analysis on the selected audio content; generating entrainment assistance cue(s) to the selected audio content, the assistance cue(s) including a sound added to the audio content; applying the assistance cues to the audio content simultaneously with playing the selected audio content; evaluating a therapeutic effect on the patient, wherein the selected audio content continues to play when a therapeutic threshold is detected, and a second audio content is selected for delivery to the patient when a therapeutic threshold is not detected.

Abstract: A method for stimulating neural activity in the brain of a user of an apparatus with a display screen by causing at least one portion of the display screen to flicker in a controlled manner and utilizing the apparatus to measure an effect on a user exposed to the flicker for a time.

Abstract: An ultrasound catheter with fluid delivery lumens, fluid evacuation lumens and a light source is used for the treatment of intracerebral hemorrhages. After the catheter is inserted into a blood clot in the brain, a lytic drug can be delivered to the blood clot via the fluid delivery lumens while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the fluid evacuation lumens.

Abstract: A delivery tube and cap are configured to be connected to a container that houses fluid to be delivered to a nasal cavity. The delivery tube includes an inner cannula that is positioned within an outer cannula. Each of the cannulas includes a first outlet with one or more openings aligned along a first lateral section and a second outlet with one or more openings aligned along a second lateral section. The delivery tube and cap are configured to provide relative axial movement between the cannulas. The cannulas are positionable between a first axial position that aligns the first outlets along the first lateral section of the delivery tube to deliver the fluid out of the device in a first lateral direction, and a second axial position that aligns the second outlets along the second lateral section to deliver fluid out of the device in a second lateral direction.

Abstract: Described embodiments include a system for inspecting a tubular device that includes an outer surface and a spatially-periodic supporting structure beneath the outer surface. The system includes an imaging device, configured to acquire an image of a reflection of light from the outer surface, and a processor, configured to ascertain a spatial frequency of the supporting structure by processing the image. Other embodiments are also described.