Patents Issued in August 18, 2020
  • Patent number: 10745738
    Abstract: In a method for measuring luminescence of a biological sample utilizing two different luminescence reagents, the sample is agitated to improve mixing with the second luminescence reagent, allowing for a shorter delay time between injection of the second reagent and measurement of the resulting luminescence activity. The improved mixing may also allow for a shorter measurement time, thereby improving throughput when assaying a large number of samples.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: August 18, 2020
    Assignee: Molecular Devices, LLC
    Inventors: Daniel Stock, Georg Kronberger, Michael Katzlinger
  • Patent number: 10745739
    Abstract: Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavior using mineral coatings that allow for the enhanced transfection of cells. The mineral coatings bind polynucleotides and provide a source of calcium and phosphate ions to enhance transfection. The present disclosure also provides a high throughput platform for screening non-viral transfection of cells. The methods of the present disclosure also provide an advantageous polynucleotide delivery platform because the mineral coatings may be deposited on various medical device materials after being specifically developed using the high throughput screening platform.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: August 18, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: William L. Murphy, Siyoung Choi, Xiaohua Yu
  • Patent number: 10745740
    Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: August 18, 2020
    Assignee: Qiagen Sciences, LLC
    Inventors: Steven Gordon, Phillip A Veatch
  • Patent number: 10745741
    Abstract: The present invention relates to the field of microfluidics and in particular to methods for co-localizing a particle comprising DNA and/or RNA with a known barcode oligonucleotide. Thereby, the transcriptome or DNA of a cell can be barcoded and correlated to a cell phenotype or examined for the effect of a drug on the cell. The invention also provides microfluidic devices and systems having properties which make them particularly suitable for use in the methods of the invention.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: August 18, 2020
    Assignee: EUROPEAN MOLECULAR BIOLOGY LABORATORY
    Inventors: Ramesh Utharala, Chawaree Chaipan, Lukas Nögel, Christoph A. Merten
  • Patent number: 10745742
    Abstract: The present disclosure provides methods of generating supports (e.g., beads) comprising barcode molecules coupled thereto. A barcode molecule coupled to a support may comprise a barcode sequence and a functional sequence. A barcode molecule may be generated using two or more ligation reactions in a combinatorial fashion. A support comprising two or more different barcode molecules may be useful for analyzing or processing one or more analytes such as nucleic acid molecules, proteins, and/or perturbation agents.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: August 18, 2020
    Assignee: 10X GENOMICS, INC.
    Inventors: Zachary Bent, Elliott Meer, Daniel Riordan, Paul Ryvkin, Niranjan Srinivas, Jessica Terry
  • Patent number: 10745743
    Abstract: The invention relates to the use of inductively coupled plasma mass spectroscopy for cellular sample analysis. In some embodiments a method of performing mass spectroscopy analysis using an inductively coupled plasma mass spectroscopy system is provided. The method may include introducing a cellular sample comprising one or more cells or cellular particles into an inductively coupled plasma of the inductively coupled plasma mass spectroscopy system. The method may further include using the inductively coupled plasma mass spectroscopy system to assess the cellular sample by detecting and measuring one or more element tags in the cellular sample based on the element or isotopic compositions of the one or more element tags.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: August 18, 2020
    Assignee: FLUIDIGM CANADA INC.
    Inventor: Olga Ornatsky
  • Patent number: 10745744
    Abstract: The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: August 18, 2020
    Assignees: University of Massachusetts, Massachusetts Institute of Technology, President and Fellows of Harvard College, Whitehead Institute for Biomedical Research
    Inventors: Job Dekker, Erez Lieberman Aiden, Nynke Van Berkum, Andreas Gnirke, Eric Lander, Chad Nusbaum, Louise Williams, Alexandre Melnikov, Georgia Giannoukos
  • Patent number: 10745745
    Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such nucleic acid polymerases and primers.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: August 18, 2020
    Assignee: Labrador Diagnostics LLC
    Inventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
  • Patent number: 10745746
    Abstract: The present disclosure provides, in various aspects and embodiments, methods and compositions for selectively amplifying a rare target nucleic acid and/or suppressing amplification of non-target nucleic acids with sequences similar to the rare target nucleic acid. The methods and composition are useful, for example, for detecting rare alleles among a population of wild-type alleles.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: August 18, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Xi Chen, David Yu Zhang, Peng Yin
  • Patent number: 10745747
    Abstract: The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof, such as modified Taq polymerases, are provided that allow for improved nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having improved thermostability, accuracy, processivity and/or read length as compared to a referenceTaq polymerase. In some aspects, the disclosure relates to modified polymerases or biologically active fragments thereof, useful for amplification methods, and in practically illustrative embodiments, emulsion PCR.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: August 18, 2020
    Assignee: Life Technologies Corporation
    Inventors: Daniel Mazur, Eileen Tozer, Sihong Chen, Peter Vander Horn, Tommie Lincecum
  • Patent number: 10745748
    Abstract: In some embodiments, a variety of devices and methods for conducting microfluidic analyses are utilized herein, including devices that can be utilized to conduct thermal cycling reactions such as nucleic acid amplification reactions. The devices include elastomeric components; in some instances, much or all of the device is composed of elastomeric material. Amplification products (amplicons) can be detected and distinguished (whether isolated in a reaction chamber or at any subsequent time) using routine methods for detecting nucleic acids. An example of a detection method includes hybridization to arrays of immobilized oligo or polynucleotides.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: August 18, 2020
    Assignee: FLUIDIGM CORPORATION
    Inventors: Marc A. Unger, Geoffrey Richard Facer, Barry Clerkson, Christopher G. Cesar, Neil Switz
  • Patent number: 10745749
    Abstract: The present invention provides methods for detecting the presence or absence of a nucleic acid variant in a target region. These methods include amplifying the target region with a forward primer and a reverse primer in the presence of a selector blocker. The selector blocker includes a sequence complementary to the target region in the absence of the nucleic acid variant. The methods further include detecting amplification of the target region where amplification of the target region indicates the presence of the nucleic acid variant in the target region. The nucleic acid variant can include deletions, mutations or insertions.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: August 18, 2020
    Assignees: Biocept, Inc., Aegea Biotechnologies
    Inventor: Lyle Arnold
  • Patent number: 10745750
    Abstract: Nucleic acid compositions, methods of making and using such compositions that comprise modular functional groups that can be configured to provide desired functionality to different nucleotide types through a swappable and preferably non-covalent linkage component. Such compositions are useful in a variety of applications including nucleic acid analyses.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: August 18, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Jonas Korlach, Jeffrey Wegener
  • Patent number: 10745751
    Abstract: Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3? sugar hydroxyl, as well as methods and kits using the same.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: August 18, 2020
    Assignee: ILLUMINA, INC.
    Inventors: Erin Bomati, Molly He, Cheng-Yao Chen, Sergio Peisajovich
  • Patent number: 10745752
    Abstract: The generation of clinical-grade cell-based therapies from human embryonic stein cells or cells reprogrammed to pluripotency from somatic cells, requires stringent quality controls to insure that the cells have long enough telomeres and resulting cellular lifespan to be clinically useful, and normal gene expression and genomic integrity so as to insure cells with a desired and reproducible phenotype and to reduce the risk of the malignant transformation of cells. Assays useful in identifying human embryonic stem cell lines and pluripotent cells resulting from the transcriptional reprogramming of somatic cells that have embryonic telomere length are described as well as quality control assays for screening genomic integrity in cells expanded and banked for therapeutic use, as well as assays to identify cells capable of abnormal immortalization.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: August 18, 2020
    Inventors: Michael D. West, Karen B. Chapman, Walter D. Funk
  • Patent number: 10745753
    Abstract: A method, kit and primers for determining alleles present in a DNA sample that is sourced from either a mouse or a cell line derived from a mouse. A set of STR marker loci are selected that can be amplified together in a multiplex amplification reaction. The set of STR marker loci are selected from the group consisting of: 18-3, 4-2, 6-7, 15-3, 6-4, 12-1, 5-5, X-1, Mo11-1, Mo19-2, Mo1-2, Mo7-1, Mo1-1, Mo3-2, Mo8-1, Mo2-1, Mo11-2, Mo17-2, Mo13-1, D8S1106 and D4S2408. A set of oligonucleotide primer pairs are provided. Each oligonucleotide primer pair flanks a single locus in the set of STR marker loci, which are co-amplified in a multiplex amplification reaction, with the product(s) comprising a mixture of amplified alleles from each of the co-amplified loci in the set of STR marker loci. The products are evaluated to determine the alleles present at each of the loci analyzed.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 18, 2020
    Assignee: Government of the United States of America, as Represented by the Secretary of Commerce
    Inventors: Jamie Almeida, Kenneth Cole
  • Patent number: 10745754
    Abstract: Particular aspects of the invention confirm significant differences in methylation of cytosine bases in many loci throughout the genome in cases of congenital heart defect (CHD) compared to normal cases without CHD. Additional aspects provide novel methods for the prediction of congenital heart defects that can be applied to embryos, fetuses, newborns and different stages of postnatal life including childhood and any time in later postnatal life, is disclosed. The method is applicable not only to deoxyribonucleic acid (DNA) found in body fluids such as blood, urine, sputum, amniotic fluid and other tissues of affected individuals in pre- and post-natal life.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: August 18, 2020
    Assignee: Bioscreening & Diagnostics LLC
    Inventor: Ray O. Bahado-Singh
  • Patent number: 10745755
    Abstract: The disclosure relates to the identification and the use of compounds which regulate the expression of at least one Sestrin gene, for preventing and/or attenuating skin ageing, and/or for hydrating the skin and/or for regulating skin pigmentation. The method includes the following steps: a. bringing at least one test compound in contact with a sample of human keratinocytes or melanocytes; b. measuring the expression of at least one Sestrin gene chosen from SESN3, SESN2 and SESN1 in the keratinocytes or melanocytes; c. selecting the compounds for which an activation of at least 1.6 fold of the expression of at least one of the genes is measured in the keratinocytes treated in a. compared with the untreated keratinocytes, or for which a significant modulation of the expression of at least one of the genes is measured in the melanocytes treated in a. compared with the untreated melanocytes.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: August 18, 2020
    Assignee: CHANEL PARFUMS BEAUTE
    Inventors: Gaelle Gendronneau, Irina Berlin, Francois Lejeune, Julie Latreille
  • Patent number: 10745756
    Abstract: Described herein are compounds useful for the treatment and investigation of diseases, methods for the prediction of in vivo toxicity of compounds useful for the treatment and investigation of diseases, and methods of discovering and identifying compounds useful for the treatment and investigation of diseases that have reduced in vivo toxicity.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: August 18, 2020
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventor: Sebastien Burel
  • Patent number: 10745757
    Abstract: Collections of polynucleotides useful for estimating breeding value or detecting likelihood of an increased susceptibility to contracting paratuberculosis are disclosed. The polynucleotides are used to detect genomic sequences quantitatively associated with an increased susceptibility to contracting paratuberculosis. Methods for using the collections to estimate breeding value or predict likelihood of an increased susceptibility to contracting paratuberculosis are also provided. Kits comprising the collection of polynucleotides are also provided.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: August 18, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Brian W. Kirkpatrick, George E. Shook, Michael T. Collins
  • Patent number: 10745759
    Abstract: The present invention is directed to methods of prognosing relapsed leukemia in a subject. These methods are based on the detection of one or more relapse-specific gene mutations in a patient sample. The present invention further relates to methods of preventing and treating relapse leukemia in a subject based on the determined prognosis of the subject.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: August 18, 2020
    Assignee: NEW YORK UNIVERSITY
    Inventors: William L. Carroll, Julia A. Meyer
  • Patent number: 10745760
    Abstract: There is provided herein, systems, devices and methods for determining a risk of recurrence of cancer following a cancer therapy of a patient by determining genomic instability of a tumour. There is further provided systems, devices and methods for categorizing a patient into a prognostic cancer sub-group by using copy number alterations.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: August 18, 2020
    Assignees: University Health Network, Ontario Institute for Cancer Research
    Inventors: Paul Boutros, Robert G. Bristow, Emilie Lalonde
  • Patent number: 10745761
    Abstract: The present invention relates to methods and systems for high risk screening, diagnosis, prognosis, and surveillance of lung cancer. Accordingly, in one aspect, the invention provides a method for diagnosing or evaluating whether a subject has, or is at risk of having, lung cancer such as NSCLS. The method comprises obtaining a first expression level of the AKAP4 gene of a population of cells from the blood of a test subject; and comparing the first expression level with a first predetermined reference value. A difference between the first expression level and first predetermined reference value correlates with a diagnosis or evaluation of a lung cancer.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: August 18, 2020
    Assignees: Valley Health System, The Wistar Institute of Anatomy and Biology
    Inventors: Kiranmai Gumireddy, Qihong Huang, Louise C. Showe, Ganepola A Ganepola
  • Patent number: 10745762
    Abstract: The disclosed embodiments relate to method, system and apparatus for synthesizing a target polynucleotide within a droplet. In an exemplary embodiment, the disclosure provides a method of synthesizing a target polynucleotide. The method includes the steps of: contacting a polynucleotide-containing component from a sample with lysis reagents in a droplet, the lysis reagents comprising an enzyme having protease activity, wherein the droplet is encapsulated with an immiscible carrier fluid; moving the droplet into a collection reservoir; incubating the droplet in the collection reservoir for a first duration and then inactivating the enzyme having protease activity; adding to the droplet a nucleic acid synthesis reagent to form a nucleic acid synthesis droplet in the immiscible carrier fluid to form a nucleic acid droplet; and synthesizing the target polynucleotide within the nucleic acid synthesis droplet.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: August 18, 2020
    Assignee: The Regents of the University of California
    Inventors: Adam R. Abate, Dennis Jay Eastburn, Adam R. Sciambi
  • Patent number: 10745763
    Abstract: The invention generally relates to a system for isolating or separating a target from a sample. In certain aspects, processes performed by the target capture system include introducing a plurality of magnetic particles, in which a plurality of the particles include at least one binding moiety specific to a target, into a sample to form at least one target/particle complex and applying a magnetic field to isolate the magnetic particle/target complexes from the sample. The process starts at inputting a sample into the system and ends at delivering a capture target or nucleic acids of the target into a container for further analysis.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: August 18, 2020
    Assignee: DNAE Group Holdings Limited
    Inventors: Ravil A. Sitdikov, Eddie W. Adams, Magdalena A. Torrance, David K. Aley, Erik J. Smith, Victor C. Esch
  • Patent number: 10745764
    Abstract: Embodiments of the invention provide a method of genotyping a C. gattii sample, which can include forming a plurality of mixtures for nucleic amplification. The method can include amplification of specific sequences within the C. gattii genome that can provide definitive genotype information to distinguish between one or more types or subtypes of C. gattii.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: August 18, 2020
    Assignees: The Translational Genomics Research Institiute, Arizona Board of Regents on Behalf of Northern Arizona University
    Inventors: David Engelthaler, Elizabeth Driebe, Erin Kelley, Paul Keim
  • Patent number: 10745765
    Abstract: The disclosed invention is related to methods, compositions, kits and isolated nucleic acid sequences for targeting Adenovirus nucleic acid. Compositions include amplification oligomers and/or detection probe oligomers. Kits and methods comprise at least one of these oligomers.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: August 18, 2020
    Assignee: GEN-PROBE PRODESSE, INC.
    Inventors: Emily Ziegler, Jessica Townsend
  • Patent number: 10745766
    Abstract: Applicant discloses herein kits for identifying the presence of Zika virus in a sample. In embodiments, these kits comprise reagents disclosed herein. Applicant further provides kits for use in detecting ZIKV in a sample, the kits comprising reagents disclosed herein. In embodiments, kits include primers directed to Zika virus (ZIKV) nucleic acid sequences, the primers capable of hybridizing to ZIKV nucleic acids and to copies of ZIKV nucleic acids (including to cDNA copies of ZIKV nucleic acids). Applicant discloses herein reagents for detecting Zika virus (ZIKV) in a sample, the reagents including one or more nucleic acid primers that are capable of hybridizing to a ZIKV nucleic acid (including to cDNA copies of ZIKV nucleic acids).
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: August 18, 2020
    Assignee: Labrador Diagnostics LLC
    Inventors: Chandan Shee, Jerzy Majka, Bernardo Araujo, Ushati Das Chakravarty, Katrina Sullivan-Bibee, Jerald Sapida, Kristine Salazar
  • Patent number: 10745767
    Abstract: Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers that facilitate detection of very low levels of HBV nucleic acids.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: August 18, 2020
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Jeffrey M. Linnen, Daniel P. Kolk, Janel M. Dockter, Damon K. Getman, Tadashi Yoshimura, Martha K. Ho-Sing-Loy, Reinhold B. Pollner, Leslie A. Stringfellow
  • Patent number: 10745768
    Abstract: A stretching apparatus for stretching a pelt on a pelt board, wherein the pelt has a substantially tubular shape defining an inwardly oriented leather side, an outwardly oriented fur side, a nose end, a rear end and a pair of front leg cavities. The pelt board defines a top end for accommodating and fixating the nose end of the pelt, a circumferential wall for facing the inwardly oriented leather side of the pelt and a base end located opposite the top end. The stretching apparatus comprises a holding device for holding the base end of the pelt board, and a stretching device having a pair of stretching members. Each of the stretching members are adapted in order to be inserted into a respective front leg cavity of the pelt and the stretching device is movable in a direction towards the holding device for stretching the pelt.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: August 18, 2020
    Assignee: MINKPAPIR A/S
    Inventors: Mogens Fahlgren Andersen, Soren Frolund
  • Patent number: 10745769
    Abstract: The invention discloses a method for treating an animal substrate comprising: agitating the moistened animal substrate with a treatment formulation and a solid particulate material in a sealed apparatus wherein the treatment formulation comprises a tanning agent or a tannery process agent. The method can comprise applying the tanning agent or tannery process agent to the animal substrate wherein at least some of the agent so applied originates from the treatment formulation. There is also disclosed an animal substrate obtained by the method. The treatment formulation can be aqueous.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: August 18, 2020
    Assignee: Xeros Limited
    Inventor: John Edward Steele
  • Patent number: 10745770
    Abstract: The present invention provides a method of simultaneously recycling plastics and detoxifying chromite ore processing residue with residual heat from a steel slag. By heating and gasifying plastics with steel slag, followed by catalytically split-decomposing the plastics with catalysts such as chromite ore processing residue, the plastics are thoroughly converted into a energy gas under water vapor gasification. The surface coking of Chromite Ore Processing Residue is avoided. Meanwhile, the energy gas reduces Cr6+ in Chromite Ore Processing Residue into Cr3+, and the energy gas is cooled, and CO2 and Cl in the energy gas are adsorbed by alkaline substances in Chromite Ore Processing Residue. With this method, chromite ore processing residue is detoxified, and steel slag is cooled, furthermore, energy is saved and a energy gas is obtained.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: August 18, 2020
    Assignee: QINGDAO TECHNOLOGICAL UNIVERSITY
    Inventors: Dalei Zhang, Shenqian Deng, Jian Li, Ruidong Li, Yuanfeng Qi
  • Patent number: 10745771
    Abstract: A molten steel refining method includes throwing a powder to molten steel while heating the powder with a flame formed by combustion of a hydrocarbon gas at the leading end of a top blowing lance. The lance height of the top blowing lance (the distance between the static bath surface of the molten steel and the leading end of the lance) is controlled to 1.0 to 7.0 m, and the dynamic pressure P of a jet flow ejected from the top blowing lance calculated from equation (1) below is controlled to 20.0 kPa or more and 100.0 kPa or less. P=?g× U2/2 . . . (1) wherein P is the dynamic pressure (kPa) of the jet flow at an exit of the top blowing lance, ?g the density (kg/Nm3) of the jet flow, and U the velocity (m/sec) of the jet flow at the exit of the top blowing lance.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: August 18, 2020
    Assignee: JFE STEEL CORPORATION
    Inventors: Yusuke Fujii, Yoshie Nakai, Naoki Kikuchi, Naoya Shibuta, Shinichi Nagai, Takahiko Maeda, Yuji Miki
  • Patent number: 10745772
    Abstract: The present invention provides an age hardening type bainitic microalloyed steel having a composition which includes, in terms of mass %: 0.06-0.35% of C; 0.01-2.00% of Si; 0.10-3.00% of Mn; 0.001-0.200% of S; 0.001-2.00% of Cu; 0.40-3.00% of Ni; 0.10-3.00% of Cr; 0.10-1.00% of Mo; 0.10-1.00% of V; and 0.001-0.100% of s-Al, with the remainder being Fe and unavoidable impurities, and which satisfies a value of the following expression (1) to be 20 or larger and a value of the following expression (2) to be 0.82 or larger: 3×[C]+10×[Mn]+2×[Cu]+2×[Ni]+12×[Cr]+9×[Mo]+2×[V]??expression (1); 1.66×[C]+0.18×[Si]+0.27×[Mn]+0.09×[Ni]+0.32×[Cr]+0.34×[Mo]+0.44×[V]??expression (2), in which each [ ] in the expression (1) and the expression (2) indicates a content of the element shown therein in terms of mass %.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: August 18, 2020
    Assignees: DAIDO STEEL CO., LTD., DENSO CORPORATION
    Inventors: Yuuki Tanaka, Makoto Haritani, Takahiro Miyazaki, Kouji Morita, Yoshihiro Tanimura, Toshimasa Ito, Tadashi Nishiwaki, Tomomitsu Fukuoka
  • Patent number: 10745773
    Abstract: This device scans a high-energy beam in a direction traversing a feed path of a grain-oriented electrical steel sheet having subjected to final annealing so as to irradiate a surface of the steel sheet being passed through with the high-energy beam to thereby perform magnetic domain refinement, the device including an irradiation mechanism for scanning the high-energy beam in a direction orthogonal to the feed direction of the steel sheet, in which the irradiation mechanism has a function of having the scanning direction of the high-energy beam oriented diagonally, relative to the orthogonal direction, toward the feed direction at an angle determined based on a sheet passing speed of the steel sheet on the feed path.
    Type: Grant
    Filed: December 25, 2012
    Date of Patent: August 18, 2020
    Assignee: JFE STEEL CORPORATION
    Inventors: Seiji Okabe, Shigehiro Takajo, Yasushi Kitani
  • Patent number: 10745774
    Abstract: A ferrite-martensite dual-phase stainless steel has satisfactory corrosion resistance and workability for a material for the body of a freight car and excellent low-temperature toughness. The ferrite-martensite dual-phase stainless steel has a specified chemical composition, in which inequalities (I) and (II) below are satisfied, and a steel microstructure including a dual phase of a ferrite phase and a martensite phase, in which the content of the martensite phase is 5% or more and 95% or less in terms of vol. %: 10.5?Cr+1.5×Si?13.5??(I) 1.5?30×(C+N)+Ni+0.5×Mn?6.0??(II), where Cr and Si in inequality (I) above and C, N, Ni, and Mn in inequality (II) above respectively represent the contents (mass %) of the corresponding chemical elements.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: August 18, 2020
    Assignee: JFE Steel Corporation
    Inventors: Tomohiro Ishii, Hiroki Ota, Chikara Kami, Saiichi Murata, Mitsuyuki Fujisawa, Genichi Ishibashi
  • Patent number: 10745775
    Abstract: A steel sheet for galvannealed steel contains, by mass %, C: 0.25 to 0.70%, Si: 0.25 to 2.50%, Mn: 1.00 to 5.00%, Al: 0.005 to 3.50%, P: 0.15% or less, S: 0.03% or less, N £ 0.02%, O £ 0.01%, and optionally one or more selected from Ti, Nb, V, Cr, Mo, Cu, Ni, B, Ca, REM, Mg, W, Zr, Sb, Sn, As, Te, Y, Hf and Co, a balance being Fe and impurities. The microstructure consists of, by vol. %, retained g: 10.0 to 60.0%, high-temperature tempered martensite3 5.0%, low-temperature tempered martensite3 5.0%, fresh martensite £ 10.0%, a: 0 to 15.0%, P: 0 to 10.0%, a balance being bainite. Total volume ratio of tempered martensite and bainite is 30.0% or more, tensile strength is 1470 MPa or more, tensile strength×uniform elongation is 13000 MPa % or more, and tensile strength×local elongation is 5000 MPa % or more.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: August 18, 2020
    Assignee: NIPPON STEEL CORPORATION
    Inventors: Kohichi Sano, Jun Haga, Koutarou Hayashi, Hiroyuki Kawata, Riki Okamoto, Akihiro Uenishi
  • Patent number: 10745776
    Abstract: A method and a device for increasing a laser induced shock wave pressure. According to the method, plasmas (21) are generated by impinging an aluminium foil (20) using lasers; a high-voltage pulse electrode (22) discharges to the plasmas (21) to induce and form a photoelectric combined energy field and then high-temperature plasmas (21) having the characteristics of an ultra-high density and an ultra-high speed expansion are induced and generated; a surface to be processed is impacted by the high-temperature plasmas (21) in a restrained state; the laser induced shock wave pressure is increased substantially; the surface of a high-strength material is reinforced, and the strength, hardness, abrasion resistance and anti-fatigue performances of the high-strength material are improved. The device comprises a laser, the electrode (22), a high-voltage power supply (4), a discharging medium (12), a moving platform, etc.
    Type: Grant
    Filed: September 7, 2015
    Date of Patent: August 18, 2020
    Assignee: JIANGSU UNIVERSITY
    Inventors: Jianzhong Zhou, Xiankai Meng, Shu Huang, Jie Sheng, Chun Su, Hongda Zhou, Xiangwei Yang, Hansong Chen
  • Patent number: 10745777
    Abstract: Oxygen is injected into the windbox of a fluidized bed ore roaster to form a fluidizing and oxidizing gas stream of elevated oxygen content which is fed into only the feed zone into which the ore to be fluidized is fed.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: August 18, 2020
    Assignee: PRAXAIR TECHNOLOGY, INC
    Inventors: William J Mahoney, Ahmed F Abdelwahab, Jeffrey C Mocsari, Wim Coessens, Dany BourdeaudHuy, Ozhan Turgut
  • Patent number: 10745778
    Abstract: Leaching aids, for example, when present in a leaching solution, and methods of using the leaching aids. The leaching aids can include one or a combination of compounds. The method of using the leaching aids can include a process of recovering metal from ore, for example, a process involving heap leaching, solvent extraction and electrowinning.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: August 18, 2020
    Assignee: BASF SE
    Inventors: Jack Thomas Bender, Nathan Clark Emmerich, Russell Vincent Brewer, Lauren Michele Hight
  • Patent number: 10745779
    Abstract: A wrought machinable low copper, silicon, zinc alloy having a copper content between about 66 weight percent and about 69 weight percent and wherein the silicon content is between about 1.53 weight percent and about 2.0 weight percent.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: August 18, 2020
    Assignee: WIELAND CHASE, LLC
    Inventors: David Dean McDevitt, Charles Lawrence Muller
  • Patent number: 10745780
    Abstract: Provided is a Cu-based sintered bearing comprising: 15-36 mass % of Ni; 3-13 mass % of Sn; 0.05-0.55 mass % of P; and 0.02-4 mass % of C in total, the balance consisting of Cu and inevitable impurities, wherein the content of C forming an alloy with a matrix within Cu—Ni-based main phase grains is 0.02-0.10 mass %.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: August 18, 2020
    Assignee: Diamet Corporation
    Inventors: Yoshinari Ishii, Shinichi Takezoe, Tsuneo Maruyama
  • Patent number: 10745781
    Abstract: An alumina-forming, high temperature creep resistant alloy is composed essentially of, in terms of weight percent: up to 10 Fe, 3.3 to 4.6 Al, 6 to 22 Cr, 0.68 to 0.74 Mn, 5.2 to 6.6 Mo, 0.4 to 1.2 Ti, up to 0.1 Hf, 0.005 to 0.05 La, 0.4 to 0.6 W, 0.1 to 0.35 C, up to 0.002 B, 0.001 to 0.02 N, balance Ni.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: August 18, 2020
    Assignee: UT-BATTELLE, LLC
    Inventors: Govindarajan Muralidharan, Bruce A. Pint
  • Patent number: 10745782
    Abstract: Magnesium alloys comprising a long period stacking order (LPSO) phase having an 14H-i or an 18R-i structure are provided. The alloys comprise magnesium as a majority element, a first alloying element that is larger than magnesium and a second alloying element that is smaller than magnesium.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: August 18, 2020
    Assignee: Northwestern University
    Inventors: Christopher M. Wolverton, James E. Saal
  • Patent number: 10745783
    Abstract: A cemented carbide comprising a first hard phase composed of tungsten carbide particles and a binder phase including Co, the cemented carbide having a ratio Nt/Na of 0.9 or more, where, in any surface or any cross section of the cemented carbide, a region in which there is a distance X of 5 nm or less between surfaces respectively of tungsten carbide particles adjacent to each other, the surfaces facing each other along a length L of 100 nm or more, is referred to as a WC/WC interface, and Na represents a total number of WC/WC interfaces and Nt represents a number of WC/WC interfaces having distance X of 1 nm or more and 5 nm or less and having therein an atomic percentage of Co higher than an average value of atomic percentages of Co in the tungsten carbide particles.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: August 18, 2020
    Assignee: Sumitomo Electric Hardmetal Corp.
    Inventors: Yasuki Kido, Daiji Tabayashi, Shinya Imamura
  • Patent number: 10745784
    Abstract: A high rigid spheroidal graphite cast iron, comprising: more than 3.0% to less than 3.6% of C, 1.5 to 3.0% of Si, 1.0% or less of Mn, 1.0% or less of Cu, less than 0.03% of P, 0.02% to 0.07% of Mg, residual Fe and inevitable impurities, as represented by mass %, wherein a carbon equivalent (a CE value) calculated by the mathematical expression (1): CE=C %+Si %/3 in terms of C and Si contents is 3.6 to 4.3%, the Young's modulus is 170 GPa or more, the tensile strength is 550 MPa or more, and the impact value is 12 J/cm2 or more.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: August 18, 2020
    Assignee: KABUSHIKI KAISHA RIKEN
    Inventors: Tomoyuki Tobita, Tadaaki Kanbayashi
  • Patent number: 10745785
    Abstract: A high-performance low-alloy wear-resistant steel sheet and a method of manufacturing the same, which has the chemical compositions (wt %): C: 0.21-0.32%; Si: 0.10-0.50%; Mn: 0.60-1.60%; B: 0.0005-0.0040%; Cr: less than or equal to 1.50%; Mo: less than or equal to 0.80%; Ni: less than or equal to 1.50%; Nb: less than or equal to 0.080%; V: less than or equal to 0.080%; Ti: less than or equal to 0.060%; Al: 0.010-0.080%, Ca: 0.0010-0.0080%, N: less than or equal to 0.0080%, O: less than or equal to 0.0080%, H: less than or equal to 0.0004%, P: less than or equal to 0.015%, S: less than or equal to 0.010%, and (Cr/5+Mn/6+50B): more than or equal to 0.20% and less than or equal to 0.55%; (Mo/3+Ni/5+2Nb): more than or equal to 0.02% and less than or equal to 0.45%; (Al+Ti): more than or equal to 0.01% and less than or equal to 0.13%, the remainders being Fe and unavoidable impurities.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: August 18, 2020
    Assignee: Baoshan Iron & Steel Co., Ltd.
    Inventors: Hongbin Li, Liandeng Yao, Xiaobo Wang
  • Patent number: 10745786
    Abstract: A method for producing an iron-based sintered alloy, which is used in sliding components in pairs and has a composition including, in terms of percent by mass, Ti: 18.4 to 24.6%, Mo: 2.8 to 6.6%, C: 4.7 to 7.0%, Cr: 7.5 to 10.0%, Ni: 4.5 to 6.5%, Co: 1.5 to 4.5%, Al: 0.6 to 1.0%, the balance being Fe and unavoidable impurities, wherein the method is carried out such that the alloy has a structure in which hard particles are dispersed in an island form in a matrix and, while an area ratio thereof is kept constant, a maximum circle equivalent diameter thereof is controlled to a predetermined value of 40 to 10 ?m.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: August 18, 2020
    Assignee: THE JAPAN STEEL WORKS, LTD.
    Inventors: Yusuke Watanabe, Kakeru Kusada, Tetsuo Makida, Youhei Sawamura
  • Patent number: 10745787
    Abstract: A copper alloy sheet material has a copper alloy component system that has a high conductivity of 75.0% IACS or more and has both high strength and good stress relaxation resistance characteristics. A copper alloy sheet material has a composition containing, by mass %, from 0.01 to 0.50% of Zr, from 0.01 to 0.50% of Sn, a total content of from 0 to 0.50% of Mg, Al, Si, P, Ti, Cr, Mn, Co, Ni, Zn, Fe, Ag, Ca, and B, with the balance Cu, and unavoidable impurities, and a metal structure having a number density NA Of fine second phase particles having a particle diameter of approximately from 5 to 50 nm of 10.0 per 0.12 mm2 or more and a ratio NB/NA of a number density NB (per 0.012 mm2) of coarse second phase particles having a particle diameter exceeding approximately 0.2 mm and the NA of 0.50 or less.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: August 18, 2020
    Assignee: DOWA METALTECH CO., LTD.
    Inventors: Tsuyoshi Ito, Kuniaki Miyagi, Hiroto Narieda, Tomotsugu Aoyama, Akira Sugawara
  • Patent number: 10745788
    Abstract: The present invention includes composition and methods for the fabrication of very-high-aspect-ratio structures from metallic glasses. The present invention provides a method for nondestructive demolding of templates after thermoplastic molding of metallic glass features.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: August 18, 2020
    Assignee: Texas Tech University System
    Inventors: Molla Hasan, Golden Kumar