Patents Issued in September 1, 2020
  • Patent number: 10758618
    Abstract: Disclosed herein are compositions comprising an NSAID such as meloxicam and/or rizatriptan in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of pain such as migraine, arthritis, and other conditions. Also disclosed herein are methods of treating pain, such as migraine, comprising administering meloxicam and rizatriptan to a human being suffering from pain, such as migraine. For migraine, these methods may be particularly useful when the meloxicam and rizatriptan are administered while the human being is suffering from an acute attack of migraine pain or migraine aura. In some embodiments, the combination of meloxicam and rizatriptan may be administered in a manner that results in a Tmax of meloxicam of 3 hours or less.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: September 1, 2020
    Assignee: AXSOME THERAPEUTICS, INC.
    Inventor: Herriot Tabuteau
  • Patent number: 10758619
    Abstract: Formulations for chemoprevention of oral cancer and precancerous lesions, and for methods for preparing the formulations are described.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: September 1, 2020
    Assignees: THE OHIO STATE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Susan R. Mallery, Peter E. Larsen, Gary D. Stoner, Steven P. Schwendeman, Kashappa-Goud Desai
  • Patent number: 10758620
    Abstract: The invention relates to a potentiated antimicrobial agent for use in the treatment of a microbial infection, characterised in that said antimicrobial agent is used in association with a compound of formula (I), the mass ratio of compound of formula (I): antimicrobial agent varying between 8:1 and 1:10.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: September 1, 2020
    Assignee: SEPTEOS
    Inventor: Nicolas Tesse
  • Patent number: 10758621
    Abstract: The present invention relates to aqueous formulations comprising a compound neutralizing GM-CSF in concentrations of at least about 20 mg/ml, a tonicity modifier and a buffer, wherein the composition is stable. The ingredients of the formulation preferably provide stability to the compound neutralizing GM-CSF in view of long-term storage. In a preferred aspect, the formulation is for use in therapy, preferably for use in the treatment of inflammatory and autoimmune disorders, preferably including allergic and psoriatic disorders, as well as arthritic and asthmatic disorders. Furthermore, a kit comprising the formulation of the invention is provided.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: September 1, 2020
    Assignees: Amgen Research (Munich) GmbH, Takeda GmbH
    Inventors: Thomas Urbig, Thomas Boehm, Wolfram Steinhilber, Michael Molhoj
  • Patent number: 10758622
    Abstract: A self-emulsifying composition contains: 70 to 90% by weight of at least one compound selected from the group consisting of ?3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 0.5 to 6% by weight of water; 1 to 29% by weight of a polyoxyethylene sorbitan fatty acid ester as an emulsifier (optionally including a polyoxyl castor oil, and not including lecithin); and lecithin in an amount of 3 to 40 parts by weight in relation to 100 parts by weight of ?3 polyunsaturated fatty acids and the like. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: September 1, 2020
    Assignee: MOCHIDA PHARMACEUTICALS CO., LTD.
    Inventors: Hiromitsu Ito, Hirosato Fujii, Motoo Yamagata
  • Patent number: 10758623
    Abstract: The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: September 1, 2020
    Assignee: DURECT CORPORATION
    Inventors: Michael Sekar, Felix Theeuwes, Keith E Branham, John Gibson, James Matriano, Whitney Moro, John Tipton, William Van Osdol, Su Il Yum
  • Patent number: 10758624
    Abstract: The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: September 1, 2020
    Assignee: CITY OF HOPE
    Inventors: Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Dayson Friaca Moreira
  • Patent number: 10758625
    Abstract: The present invention provides a bispecific antibody capable of being combined with immune cells to enhance a targeting tumor killing capability, and a preparation method therefor and an application thereof. Antibodies and degradable nanoparticles are connected by using a chemical method, so as to make the one nanoparticle be connected to two or more antibody molecules at the same time, wherein one antibody can be specifically bound with immune cells, and the other antibody or the other antibodies can be specifically bound to tumor cells so as to achieve the effect of enhancing the capability of the immune cells for specifically killing tumor cells in a targeting way.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: September 1, 2020
    Assignee: BENHEALTH BIOPHARMACEUTIC (SHENZHEN) CO., LTD.
    Inventors: Haoyang Yu, Zhengcheng Li, Jing Su
  • Patent number: 10758626
    Abstract: The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from quinolones, NSAIDs and mixtures thereof. The present invention also relates to methods for preparing the polymer conjugates using click cycloaddition chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the post-surgical care to treat or prevent infections, provide analgesia and treat inflammation.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: September 1, 2020
    Assignee: POLYACTIVA PTY LTD
    Inventors: Stephen Lonsdale Birkett, Andrew Craig Donohue, Asha Marina D'Souza, Sarah Man Yee Ng, Adrian Sulistio, Russell John Tait, David Valade, Alan Naylor, Anton Blencowe
  • Patent number: 10758627
    Abstract: A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: September 1, 2020
    Assignee: Washington University
    Inventors: Samuel A. Wickline, Kirk Hou
  • Patent number: 10758628
    Abstract: The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also encompasses methods of production of such conjugates and compounds, as well as methods of using the same.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: September 1, 2020
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: Stepan Chuprakov, Romas Alvydas Kudirka, Jesse M. McFarland, Albert W. Garafalo, David Rabuka
  • Patent number: 10758629
    Abstract: Antisense oligomers complementary to a selected target site in the human dystrophin gene to induce exon 52 skipping are described.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: September 1, 2020
    Assignee: Sarepta Therapeutics, Inc.
    Inventors: Richard K. Bestwick, Frederick Joseph Schnell
  • Patent number: 10758630
    Abstract: A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The hydrophobic particles comprise a mean particle size of less than about 10 nm, and the nanoemulsion further includes one or more pharmaceutically active agents.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: September 1, 2020
    Assignee: The Johns Hopkins University
    Inventors: Jennifer L. Sample, Julia B. Patrone, Jason J. Benkoski, Jennifer L. Breidenich, Lisa A. Kelly, Huong Le, James C. Crookston, Marcia W. Patchan, Luis Garza, Xiomara Calderon-Colon, Joshua T. Wolfe, Mellisa L. Theodore, Amanda Nelson, Sewon Kang
  • Patent number: 10758631
    Abstract: Polymorphs of Formula I, which is 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate and methods of making are provided. A method for organ imaging, comprising administering to a subject, a diagnostic effective amount of a composition comprising a polymorph of Formula I are also provided. In one embodiment, the organ includes one or more of kidney, bladder, ureter, urethra, bile ducts, liver, and gall bladder.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: September 1, 2020
    Assignee: LI-COR, INC.
    Inventors: Vassil Elitzin, William M. Volcheck, Katie Schaepe, Rahul Patil
  • Patent number: 10758632
    Abstract: Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: September 1, 2020
    Assignees: CITY OF HOPE, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Paul Yazaki, Jack Shively, Michael Bouvet, Jonathan Delong, Yuman Fong
  • Patent number: 10758633
    Abstract: A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: September 1, 2020
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: He Wei, Oliver T. Bruns, Ou Chen, Moungi G. Bawendi
  • Patent number: 10758634
    Abstract: Disclosed are novel compounds, complexes, compositions and methods using Zirconium-89 combined with azamacrocyclic chelators in connection with PET. The compositions and methods should provide better diagnostic, prognostic and therapeutic oncology treatments relative to the presently available chelator compositions due to a variety of superior properties of the disclosed compositions. The present invention also relates to a superior method of making these compounds, complexes, compositions that allows one to make compounds/complexes (and thus, compositions) that were previously unattainable.
    Type: Grant
    Filed: March 18, 2017
    Date of Patent: September 1, 2020
    Assignee: Wake Forest University
    Inventors: Thaddeus J. Wadas, Darpan N. Pandya, Nikunj B. Bhatt
  • Patent number: 10758635
    Abstract: The present invention relates to 99mTc-maraciclatide radiopharmaceutical compositions, which are stabilised with a radioprotectant. Also described are kits for the preparation of the radiopharmaceutical compositions, as well methods of preparing such compositions from the kit. The invention also includes methods of imaging the mammalian body using the radiopharmaceutical compositions.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: September 1, 2020
    Assignee: Serac Healthcare Limited
    Inventor: David Jonathan Barnett
  • Patent number: 10758636
    Abstract: The present invention relates to conjugates including a residualizing linker, methods for their production, and uses thereof.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: September 1, 2020
    Assignee: CENTRE FOR PROBE DEVELOPMENT AND COMMERCIALIZATION
    Inventors: John Fitzmaurice Valliant, Eric Steven Burak, Neil Grant Cockburn, Alla Darwish, Joel Adamson Drewry, John Richard Forbes, Meiduo Hu, Ryan Wayne Simms, Karin Ann Stephenson, Tao Wu
  • Patent number: 10758637
    Abstract: Methodologies, systems, and devices are disclosed for generating a chemical compound. A reaction chamber holds an amount of a precursor chemical, an activator chamber holds an amount of an activator chemical, and a quenching and neutralizer chamber holds an amount of quenching and neutralizing chemicals. A pump transfers the activator chemical from the activator chamber to the reaction chamber, where the activator chemical reacts with the precursor chemical to form the desired chemical compound. The desired chemical compound is allowed to exit the reaction chamber. Subsequently, the pump transfers the quenching and neutralizing chemicals from the quenching and neutralizer chamber to the reaction chamber, resulting in a quenched and neutralized solution.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: September 1, 2020
    Assignee: TBS Technologies, LLC
    Inventors: Adrienne Clark, Paul Sabin
  • Patent number: 10758638
    Abstract: A system may automatically conduct hygiene cycles for a confined space such an interior space of a box suitable for storing and/or carrying packaged food. The system may include a hygiene device that can be attached to the box to conduct the hygiene cycles. The system may also automatically collect information related to the hygiene cycles and transmit the collected information to a network.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: September 1, 2020
    Assignee: Ecolab USA Inc.
    Inventors: Wenbin Wei, Ying Zhang, Zhili Ding, Huarong Yu
  • Patent number: 10758639
    Abstract: The present invention relates to pharmaceutical compositions and methods for the treatment of peri-implant diseases, in particular peri-implant disease characterized by the destruction of the crest of the alveolar bone supporting the implant. Specifically, the method comprising the step of applying to a peri-implant bone displaying crestal resorption a 5 pharmaceutical composition comprising biocompatible bone augmentation material coated with a matrix composition which provides local controlled and prolonged release of at least one pharmaceutically active agent at the bone loss site.
    Type: Grant
    Filed: September 27, 2015
    Date of Patent: September 1, 2020
    Assignee: Polypid Ltd.
    Inventor: Noam Emanuel
  • Patent number: 10758640
    Abstract: Silicone gels are described that are adhesive to the skin. The gels can be used in particular for articles that are adhesive to the skin for medical or paramedical use.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: September 1, 2020
    Assignee: ELKEM SILICONES FRANCE SAS
    Inventors: Caroline Moine, Maryline Quemin, Gaelle Cros
  • Patent number: 10758641
    Abstract: A method is described for the production of hybrid structures formed by the coupling of nanofibrous parts and microfibrous parts made with silk fibroin, possibly hierarchically organized into complex structures comprising more than two of said parts; these hybrid structures are used as implantable biomedical devices with tailored biological, geometrical and structural features, such that they can be adapted to different application requirements in the field of regenerative medicine.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: September 1, 2020
    Assignee: SILK BIOMATERIALS S.R.L.
    Inventor: Antonio Alessandrino
  • Patent number: 10758642
    Abstract: The present invention relates to a process for sterilizing implantable biomaterials. In particular, the invention relates to a process for sterilizing collagen-containing implantable biomaterials and storage thereafter.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: September 1, 2020
    Assignee: Admedus Regen Pty Ltd.
    Inventor: William Morris Leonard Neethling
  • Patent number: 10758643
    Abstract: A medical product which contains a mechanophore, and the use of a mechanophore for producing a medical product.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: September 1, 2020
    Assignee: Aesculap AG
    Inventors: Kris Brosig, Michael Utz
  • Patent number: 10758644
    Abstract: A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: September 1, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Kathleen Derwin, Amit Aurora, Joseph P. Iannotti, Jesse A. McCarron
  • Patent number: 10758645
    Abstract: The present invention provides, among other things, a silk ceramic material having enzymatically cross-linked amino acid side chains to generate injectable and flexible foam ceramics. Provided are compositions and methods of producing soft, flexible ceramic foam with silk polymeric crosslinking to serve as binders. Materials have applications in osteochondral and dental replacement and repair.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: September 1, 2020
    Assignee: Tufts University
    Inventors: Stephanie L. McNamara, Benjamin P. Partlow, David L. Kaplan
  • Patent number: 10758646
    Abstract: The present invention relates to a method for preparing a nerve conduit containing cells, more particularly to a method for preparing a porous nerve conduit containing cells, having micropores formed in microchannels, wherein the nerve conduit containing cells prepared according to the present invention can be usefully used in in-vitro and in-vivo researches on nerves.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: September 1, 2020
    Assignee: Wiregene Co., Ltd.
    Inventors: Jung Keun Hyun, Jong-Wan Kim, Young-Jin Son, Min Soo Kim, Hong Sun Ahn
  • Patent number: 10758647
    Abstract: A medical push button valve having a valve housing, a flow channel formed in the valve housing as well as a valve piston which is arranged displaceably in the valve housing between a position releasing the flow channel and a position closing the flow channel. The valve piston is operatively connected with a pressure element mounted on the valve housing and is spring-loaded via at least one spring element. The valve piston is biased into the position closing the flow channel with the spring-loaded pressure element. In order to provide a medical push button valve which allows for a simple and fatigue-free one-handed operation, the spring-loaded pressure element can be locked in at least one position in which the valve piston operatively connected with the pressure element at least partially releases the flow channel.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: September 1, 2020
    Assignee: KARL STORZ SE & Co. KG
    Inventor: Johannes Peter Tobien
  • Patent number: 10758648
    Abstract: Methods and devices for treatment of damaged tissue are disclosed, including treatment of wounds by employing non-electrically powered, reduced pressure therapy devices. Maintenance and control of the sub atmospheric pressure exerted may be provided by such devices while minimizing discomfort to the user. The devices may be configured to be worn inconspicuously underneath clothing.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 1, 2020
    Assignee: KCI Licensing, Inc.
    Inventors: Ryan Conner, Dean Hu, Crystal Musante, Kenneth Wu
  • Patent number: 10758649
    Abstract: Implementations described herein include a system for guiding medical waste fluid into a medical waste collection canister. The system includes a manifold and a filter. The manifold includes a top surface and a sidewall extending from the top surface in a first direction. The top surface and the sidewall define an interior chamber of the manifold. The top surface includes an inlet port and a vacuum port disposed therein. The inlet port connects to a source of medical waste fluid and the vacuum port connects to a vacuum source. The manifold can be formed from a first polymer. A filter is positioned within the interior chamber of the manifold and immediately upstream of the vacuum port so as to filter air flowing into the vacuum port. The filter extends away from the top surface of the manifold in the first direction and the filter is formed from a second polymer.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: September 1, 2020
    Assignee: Zimmer, Inc.
    Inventors: Larry C. Smith, David J Boles
  • Patent number: 10758650
    Abstract: In various aspects, the wound therapy apparatus disclosed herein includes a wound interface that defines an enclosed space over a wound bed that is fluid tight when secured to a skin surface around the wound bed. The wound therapy apparatus includes a control group that cooperates with the wound interface to regulate input of input fluid comprising a gas having an O2 concentration greater than atmospheric air into the enclosed space and to regulate the withdrawal of output fluid from the enclosed space in order to vary an actual pressure pa within the enclosed space generally between a minimum pressure pmin and a maximum pressure pmax. Related methods of use of the wound therapy apparatus are disclosed herein.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: September 1, 2020
    Inventor: Edward D Lin
  • Patent number: 10758651
    Abstract: An apparatus for cleansing wounds, in which wound exudate is removed from a wound bed and selectively cleansed and returned to the wound. The cleansing means removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The associated wound dressing and cleansing means are conformable to the wound, and may have irrigant fluid circulated from a reservoir by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: September 1, 2020
    Assignee: Smith & Nephew PLC
    Inventors: Patrick Lewis Blott, Bryan Greener, Edward Yerbury Hartwell, Derek Nicolini, Tina Michelle Walker, Julian Lee-Webb
  • Patent number: 10758652
    Abstract: A method for collecting plasma includes determining the weight and hematocrit of a donor, and inserting a venous-access device into the donor. The method then withdraws blood from the donor through a draw line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate (1) a percentage of anticoagulant in the collected plasma component, and (2) a volume of pure plasma collected within the plasma collection container. The volume of pure plasma may be based, at least in part, on the calculated percentage of anticoagulant. The method may continue until a target volume of pure plasma is collected within the plasma collection container.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: September 1, 2020
    Assignee: Haemonetics Corporation
    Inventor: Michael Ragusa
  • Patent number: 10758653
    Abstract: A system for hands-free nursing and breast pumping includes a breast compression device with a plurality of thermoformed fluid bladders designed to fit adjustably against each breast and inflate and deflate with minimal power requirements. The compression device and its controller fit inside of a nursing garment designed to receive the device and controller for optimal compression. The nursing garment and the compression device have openings over the nipples so that a breast pump flange can be inserted through them and used in a typical manner for the extraction of breast milk, thus increasing the amount of milk expressed.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: September 1, 2020
    Inventors: Sujay Suresh Kumar, Adriana Catalina Vazquez Ortiz
  • Patent number: 10758654
    Abstract: The present invention provides a rotary blood pump with both an attractive magnetic axial bearing and a hydrodynamic bearing. In one embodiment according to the present invention, a rotary pump includes an impeller assembly supported within a pump housing assembly by a magnetic axial bearing and a hydrodynamic bearing. The magnetic axial bearing includes at least two magnets oriented to attract each other. One magnet is positioned in the spindle of the pump housing while the other is disposed within the rotor assembly, proximate to the spindle. In this respect, the two magnets create an attractive axial force that at least partially maintains the relative axial position of the rotor assembly. The hydrodynamic bearing is formed between sloping surfaces that form tight clearances below the rotor assembly.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: September 1, 2020
    Assignee: TC1 LLC
    Inventors: Richard K. Wampler, David M. Lancisi
  • Patent number: 10758655
    Abstract: This document discusses, among other things, systems and methods to reduce ischemic or metabolic injury to a patient's heart. A system to reduce ischemic or metabolic injury to a patient's heart may include a pulse generator for generating electrical pulses or shock, a pacing lead with at least one pacing electrode configured to deliver electrical pulses received from the pulse generator to the patient's heart, a controller configured to control timing of electrical pulses to reduce wall stress of the heart, and a reservoir, fluidically coupled to a lumen and a pump, wherein the pump is configured, under control of the controller, to move contents from the reservoir through the lumen to an area of the heart with the reduced wall stress, wherein the contents include autologous respiration-competent mitochondria or other respiratory-promoting agents.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: September 1, 2020
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Barbara Ann Huibregtse, Thomas John Herbst, Craig Stolen, Eric M. Schneider, Lynne E. Swanson, Lili Liu
  • Patent number: 10758656
    Abstract: The present invention relates to a dialysis machine having a hydraulic system that is intended for providing a dialysis solution or an element of the dialysis solution, wherein the hydraulic system has a degassing pump for degassing the dialysis solution or an element of the dialysis solution, and having a pneumatic system in which a vacuum is present at least at times for operating a component of the dialysis machine, wherein there is a connection line between the suction side of the degassing pump and the pneumatic system for a vacuum generation in the pneumatic system.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: September 1, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Ralf Mueller, Soeren Gronau
  • Patent number: 10758657
    Abstract: An artificial lung is provided that includes a plurality of porous hollow fiber membranes for gas exchange comprising a hydrophobic polymer material, wherein the hollow fiber membranes have inner surfaces forming lumens and outer surfaces, and wherein at least one of the inner surfaces or the outer surfaces is coated with a polymer-containing solution that has a surface tension of 40 to 55 dyn/cm and that contains a solvent and a polymer having a structural unit represented by Formula (I): wherein in Formula (I), R3 represents a hydrogen atom or a methyl group, R1 represents an alkylene group having 1 to 4 carbon atoms, and R2 represents an alkyl group having 1 to 4 carbon atoms.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: September 1, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Takao Anzai, Eisuke Sasaki, Norikazu Ishida
  • Patent number: 10758658
    Abstract: An artificial lung is provided having a plurality of porous hollow fiber membranes for gas exchange, in which the hollow fiber membranes have outer surfaces, inner surfaces forming lumens, and opening portions through which the outer surfaces communicate with the inner surfaces, any one of the outer surfaces and the inner surfaces is coated with a colloidal solution of an antithrombotic material containing a polymer as a main component, and an average particle size of the colloid is at least 1.5 times a diameter of the opening portions of the hollow fiber membranes. An artificial lung is provided that can effectively suppress leakage of blood plasma components after blood circulation (blood plasma leakage).
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: September 1, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Takao Anzai, Takayuki Kido
  • Patent number: 10758659
    Abstract: The invention relates to systems and methods for optimizing a peritoneal dialysate prescription based on one or more fluid characteristics sensed from a filtrate removed from a patient. The systems and methods include sensors, flow paths, and processors to adjust a peritoneal dialysate prescription and deliver peritoneal dialysis therapy to a patient based on the adjusted prescription. The method can include the steps of removing fluid from a peritoneal cavity of a patient; sampling one or more characteristics of the removed fluid; and adjusting a peritoneal dialysate prescription based on the one or more characteristics of the removed fluid. The system can include a peritoneal dialysate effluent line; at least one concentrate source fluidly connectable to the peritoneal dialysate flow path; and at least one sensor positioned in the peritoneal dialysate effluent line.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: September 1, 2020
    Assignee: Medtronic, Inc.
    Inventors: Martin T. Gerber, Christopher M. Hobot
  • Patent number: 10758660
    Abstract: Constraining adaptive optimizations of a state of an operation module of a medical device includes determining if a new state has at least one operational parameter that is outside a constraint that has been provided to the medical device in a non-repudiable manner, accepting the new state if no operational parameters are outside any of the constraints, and reverting the medical device to a previous valid state if at least one operational parameter is outside at least one of the constraints. The adaptive optimizations may be provided using artificial intelligence along with relevant inputs thereto. The medical device may be a dialysis system. Constraint data may be provided to the medical device along with a one-way hash value of the constraint data using, for example, a SHA 256 hash. The one-way hash value may be digitally signed using a private key that is part of a public/private key pair.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: September 1, 2020
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Norbert Leinfellner, Joseph Manakkil
  • Patent number: 10758661
    Abstract: An extracorporeal blood processing system comprises a plastic molded compact manifold that supports a plurality of molded blood and dialysate fluidic pathways along with a plurality of relevant sensors, valves and pumps. A disposable dialyzer is connected to the molded manifold to complete the blood circuit of the system. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: September 1, 2020
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Thomas Patrick Robinson, Charles E. Clemens, David Jacob Mishelevich, James Roswell Braig, Barry Neil Fulkerson, Daniele Ghidoli, Russell Thomas Joseph
  • Patent number: 10758662
    Abstract: The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: September 1, 2020
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Barry Neil Fulkerson, Martin Hering, Frank Isackson
  • Patent number: 10758663
    Abstract: A split-tip catheter and methods for deploying a split-tip catheter in a right atrium are provided. The catheter is configured with a distal portion including a first and a second distal end regions elastically divergable from alignment along a splitting plane to regain a relaxed configuration. The first distal end region terminates in a first tip having a first forward opening, and the second distal end region terminates in a second tip having a second forward opening. Catheter deployment may include directing the first forward opening generally towards an anterior right atrium wall portion and applying the first forward opening to withdraw blood from the right atrium.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: September 1, 2020
    Assignee: PRISTINE ACCESS TECHNOLOGIES LTD
    Inventors: Michael Gabriel Tal, Ron Livne, Rotem Neeman
  • Patent number: 10758664
    Abstract: A centrifugal separation device of a blood component collection system comprises a data acquisition unit that acquires initial data A, an estimated data calculation unit that calculates estimated data B on the basis of the initial data A, a reaction force calculation unit which calculates a reaction force of a first applied load measurement unit on the basis of the estimated data B, and an internal pressure calculation unit that calculates an internal pressure of the first applied load measurement unit, based on the reaction force and a load detected by a first load detecting unit.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: September 1, 2020
    Assignee: Terumo Kabushiki Kaisha
    Inventor: Masatsugu Igarashi
  • Patent number: 10758665
    Abstract: A biological component collection system and a circuit internal pressure acquisition method are provided, which are capable of accurately measuring the circuit internal pressure. A centrifugal separation device of a blood component collection system comprises an estimated data calculation unit that calculates estimated data B on the basis of initial data A, and a correction unit that corrects the estimated data B in a manner so that the internal pressure calculated by a first internal pressure calculation unit becomes equivalent to the internal pressure calculated by a second internal pressure calculation unit.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: September 1, 2020
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Masatsugu Igarashi, David Benz
  • Patent number: 10758666
    Abstract: Systems, apparatus and methods related to improved otorhinologic irrigation and lavage comprising a drainage collector and one or more otorhinologic adapters, which are capable of coupling to an irrigation-liquid container.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: September 1, 2020
    Inventor: Joseph P. Schultz
  • Patent number: 10758667
    Abstract: A method and apparatus for cleansing the interior surfaces of body cavities employs a balloon catheter adopted to be inserted into a cavity through its ostium with the balloon in collapsed condition. An input flow tube for a cleansing and/or medicating fluid passes through a central passage in the balloon. When the balloon is inflated to establish a narrow passage between the balloon and the cavity walls, a pressurized flow of the fluid is pumped out the distal end of the input flow tube through the passage, parallel to the cavity walls, where it scours the inner wall of the cavity, removing debris as it flows out of the ostium. The fluid flow is urged toward a turbulent condition by attachments to the outer wall of the balloon.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: September 1, 2020
    Inventor: Michael Rontal