Abstract: Embodiments provide apparatus and methods for delivering liquid form medication within the body wherein the medication is stored in solid form and then mixed with a liquid in an apparatus implanted within the body. One embodiment provides an implantable apparatus for in vivo delivery of medication comprising a housing including a reservoir, a store of solid form medication (SSM) and a pump. An SSM element is added to the reservoir along with fluid to form a medication solution comprising at least one drug. The medication solution is then delivered to a delivery site using a pumping means to pump solution from the reservoir through a delivery member such as catheter to a delivery site. Embodiments of the invention are particularly useful for delivering medication to a patient to treat a medical condition over an extended period of time without requiring the patient to take external medication.

Abstract: An infusion pump includes a housing. The housing includes a tube port adapted to receive an intravenous (“IV”) tube. The tube port includes a tube channel and a rib. The tube channel has an inlet and an outlet end. The rib is positioned along the channel adjacent the outlet end. The rib is formed to extend towards the tube when the tube is passed through the tube port thereby indenting the tube and tending to prevent full occlusion of the tube. The tube port may also include a plurality of ribs positioned around a perimeter of the tube port on the exterior side of the housing. The plurality of ribs are configured to prevent an occlusion in the tube when the tube is bent on the exterior side of the housing.

Abstract: A variety of location-based and/or proximity-based features related to diabetes management systems can be used to improve maintenance compliance and/or to provide important information to PWD designated assistance entities (e.g., family, friends, givers, HCPs, emergency medicine providers) under certain conditions. In some cases, a user's location can be tracked or determined to trigger and/or time alerts about upcoming maintenance tasks in a way that will increase the likelihood that the PWD will immediately perform the designated maintenance task. In some cases, methods, devices, and systems provided herein can use proximity to non-paired mobile computing devices to deliver data to PWD designated assistance entities.

Abstract: A securement device assembly, including an adhesive layer having a top surface and a bottom surface, wherein said adhesive layer includes at least two apertures, a non-adhesive substrate secured to said bottom surface of said adhesive layer to form an integral unit, and a plurality of perforations within said integral unit.

Abstract: The subject technology is embodied in a method for predicting a delivery rate of a plurality of drugs dispensed by multiple infusion pumps at a delivery point. The method includes receiving one or more operating parameters related to multiple drug pumps and a carrier fluid pump, wherein each of the drug pumps dispenses a drug, and the carrier fluid pump dispenses a carrier fluid. The method also includes determining a delivery rate of a first drug at the delivery point. This can be done by predicting time variation of a concentration of the first drug at the delivery point based on a mathematical model of a mixed flow through a fluid path that terminates at the delivery point. The mixed flow includes the drugs and the carrier fluid. The model includes the operating parameters and a plurality of flow-parameters related to the mathematical model of the mixed flow.

Abstract: Embodiments disclosed herein are directed to systems and methods of dispensing one or more medicaments to a subject. The systems and methods utilize at least one flexible compression garment having one or more medicament dispensers therein.

Abstract: Processor-implemented methods of controlling an insulin infusion device for a user are provided here. A first method obtains a current insulin on board (IOB) value that estimates active insulin in the user, and compensates a calculated insulin infusion rate in response to the obtained IOB value. A second method supervises the operation of a glucose sensor by obtaining and processing insulin-delivered data and glucose sensor data for the user. An alert is generated if the second method determines that a current glucose sensor value has deviated from a predicted sensor glucose value by at least a threshold amount.

Abstract: The embodiments described herein may relate to methods and systems for adjusting insulin delivery. Some methods and systems may be configured to adjust insulin delivery to personalize automated insulin delivery for a person with diabetes. Such personalization may include receiving and/or determining one or more user specific dosage parameters.

Abstract: The present invention relates to a drug delivery device for setting and dispensing of a dose of a medicament is presented comprising a housing to accommodate a cartridge filled with the medicament, an electrically operated drive mechanism to be operably engaged with the cartridge to expel a predefined dose of the medicament from the cartridge, and at least one dose element displaceably arranged relative to the housing to set and/or to dispense the dose of the medicament, wherein the dose element and the drive mechanism are mechanically decoupled from each other.

Abstract: The present invention relates to a drive mechanism for a medicament delivery device, comprising a plunger rod (54) arranged to act on a stopper (28) arranged in a medicament container (16); a compression drive spring (58) operably connected to said plunger rod (54) and capable of applying a force on said plunger rod (54); a spring guide (78) arranged coaxial with, and radially outside, said compression drive spring (58), capable of preventing buckling of said drive spring, wherein said spring guide (78) comprises a resilient force element (86) capable of applying a force on said medicament container (16).

Abstract: The present application relates to a hydraulic assembly of a generator of medium-pressure and high-pressure pulsed or non-pulsed jets. The hydraulic assembly includes a hydraulic pipe with a flexible deformable zone. The flexible deformable zone can have a state of rest and a shut-off state. The hydraulic assembly includes a unit configured to hold the hydraulic pipe with a first clamp and a second clamp holding the hydraulic pipe on each side of the flexible deformable zone. The unit can form an open space between the first clamp and the second clamp.

Abstract: A cartridge interface assembly drives a stopper in a drug reservoir or a drug delivery device. An anti-rotational guide optionally moves along an axis of a cavity of the reservoir. The anti-rotational guide is optionally slidably anti-rotationally coupled to a housing of the drug delivery device. A telescoping plunger driver may include a proximal shaft and distal shaft that telescope by relative rotation. The distal shaft is optionally slidably anti-rotationally coupled to the anti-rotational guide. The shafts are optionally oriented along said axis. In some embodiments, rotating the proximal shaft with respect to the anti-rotational guide moves the guide along said axis with respect to the housing and moves the distal shaft along the axis with respect to the anti-rotational guide.

Abstract: This disclosure refers to a dosing mechanism for use in a drug delivery device implementing a dialing mode and a dispensing mode, wherein the dosing mechanism comprises a dose button, a housing and a determination unit. The dose button is activatable by the user for dose dispense, causing displacement of an indicating element connected to the housing from a first position to a second position. The determination unit is adapted such that it detects the indicating element in its second position and thereby determines that the dosing mechanism is in the dispensing mode. With some embodiments, it is possible to distinguish between the dialing mode and the dispensing mode. Some embodiments further refer to a drug delivery device comprising the above dosing mechanism.

Abstract: A safety needle and hub module for selective connection with a medical device that includes a base and a head. The module includes a needle shield for selectively covering a distal end of a needle. A needle hub is movably received within a proximal opening of the needle shield, and extends through a passageway of the needle shield. An actuation button is movably received in opposing lateral apertures of the needle shield to engage the needle shield, the needle hub and the medical device. In a first position an upper leg of the actuation button is received in a recess of the needle hub, and a lower leg of the actuation button is received in an undercut between the base and head of the medical device. In a second position, after the actuation button is actuated, the module is removable from the medical device.

Abstract: An autoinjector includes a case having a rib, a needle shroud telescopically coupled to the case, a carrier slidably arranged in the case and adapted to hold a medicament container, and a collar rotatably and slidably disposed in the case and coupled to the needle shroud and the carrier. The needle shroud is movable between a first extended position, a retracted position and a locked second extended position. The carrier is movable from a first axial position to a second axial position relative to the case. The collar abuts the rib when the needle shroud is in the first extended position and the carrier is in the first axial position, and the collar disengages the rib when the needle shroud is in the retracted position and the carrier is in the second axial position.

Abstract: A drug delivery system includes a reservoir and a drug delivery device coupled to the reservoir. The drug delivery device also may include at least one temperature-sensitive component and a lock having locked and unlocked states. The system further includes an output device, and a controller coupled to the lock and the output device. The controller may also include a temperature sensor, or may be coupled to the temperature sensor. The controller is programmed or configured to determine if the temperature of a drug in the reservoir or of the temperature-sensitive component exceeds an upper limit or is below a lower limit, and to activate the lock in either event. The controller is also programmed or configured to determine, directly or indirectly, if the temperature subsequently is between the upper and lower limits, and to unlock lock as a consequence.

Abstract: A tamper evident assembly for retaining a plunger and piston within a barrel of a syringe including an elongated tether and a cover connected to the tether and concurrently disposed in an operative position on the syringe. A connector assembly adjustably and fixedly interconnects the tether to the cover in the operative position, wherein the cover is connected in covering relation to a discharge port of the syringe concurrently to a proximal end of the tether being connected to the syringe barrel in a removal preventative relation to the piston. Movable adjustment of the tether relative to the connector assembly defines a retaining segment disposed into a taut, fixed length orientation between the proximal end of the tether and the cover, to further define the operative position.

Abstract: An ultrasonic nebulizer includes a working tank configured to be detachable with respect to a main body. The working tank includes a rod-shaped tank-side contact electrode that extends in a vertical direction along an outer wall of the working tank. A specific portion that corresponds to a portion in a circumferential direction of the outer circumferential surface of the tank-side contact electrode is exposed from the outer wall, and the remaining portion of the outer circumferential surface of the tank-side contact electrode is embedded inside of the outer wall and is connected to an electrode of an ultrasonic vibrator. A main body-side contact electrode comes into contact with the specific portion of the outer circumferential surface of the tank-side contact electrode when the working tank is mounted on the main body.

Abstract: The aerosol-generating device includes a device housing, and a receiving chamber defined within the device housing. The receiving chamber is configured to receive at least a first-type consumable and a second-type consumable, the receiving chamber including a first structure for receiving the first-type consumable and a second structure for receiving the second-type consumable. A structure selector selects between the first structure and the second structure, the first and second structures differing in at least one of a shape, a size and a position within the receiving chamber. An aerosolization system is included with at least a portion of the receiving chamber, where the receiving chamber is configured to prevent an insertion of more than one consumable into the receiving chamber.

Abstract: An apparatus for aerosolized powder delivery includes first and second chambers containing gas at first and second pressures, respectively, above atmospheric pressure. A powder is contained within the first or second chamber. The first chamber has a first external wall and a separating wall shared with the second chamber. The first external wall or the separating wall is configured to rupture if the pressure difference across it becomes equal to or greater than a threshold pressure difference. Specifically, the apparatus is configured so that the difference between the second pressure and atmospheric pressure is greater than the threshold pressure difference. Initially, the difference between the second and first pressures is less than the pressure difference required to rupture the separating wall, and the difference between the first pressure and atmospheric pressure is less than the pressure difference required to rupture the first external wall.

Abstract: An inhaler device configured to consume an accumulated capacity to contribute to generation of aerosol or aerosol imparted with flavor, a sensor configured to detect a predefined variable, an interface configured to make a notification to an inhaler of the aerosol, and a controller configured to cause the interface to function in a first mode when a detected or estimated capacity is smaller than a threshold and the variable satisfies a predefined condition for requesting the generation of the aerosol.

Abstract: A process and a metered dose inhaler, comprising: an air actuator comprising at least one inlet of liquefied gas (LG), at least one air outlet, at least one first LG-expanding volume and at least one second air-containing volume, the first and second volumes are effectively separated by means of a LG-blocking member; a container with an LG source; said container is in a fluid connection with said LG-expanding volume via the at least one LG inlet; The air actuator is facilitating a metered dose airflow by allowing the expansion of said LG in said at least one LG-expanding volume from its condensed liquid phase to its expanded gas phase. The expansion of said LG facilitates the compression of the air within said at least one air-containing volume, such that a metered dose LG-free air flow is inhalable via at least one air outlet.

Abstract: A method of operating a device for treating sleep disordered breathing (SDB), wherein the device provides continuous positive airway pressure during sleep, includes applying a treatment pressure to a patient, monitoring the patient for speech output, generating a signal in response to detected speech of the patient, and, in response to the signal, reducing the treatment pressure applied to the patient.

Abstract: An additive gas delivery apparatus, system and method for delivery of additive gas, such as nitric oxide [NO], to a patient use a control computer configured to determine if a monitored parameter indicates that a patient is connected to the additive gas delivery apparatus, determine if the additive gas delivery apparatus is in a passive state in which it does not deliver additive gas, and activate an alarm if the additive gas delivery apparatus is in said passive state when the monitored parameter indicates that a patient is connected to the additive gas deliver apparatus. The alarm serves to notify the user of undesired non-delivery of additive gas, and so serves to improve safety in additive gas delivery systems.

Abstract: A breathing assistance apparatus is configured with features that improve serviceability of the apparatus. The apparatus can include animations to provide instruction regarding correcting easily-identified fault conditions and to provide instruction regarding routine maintenance routines. The apparatus also can be configured with top level control menus that are obscured in a manner to limit manipulation of the top level control elements by unauthorized users.

Abstract: The present disclosure relates to a method and a mechanical ventilation system for adjusting a level of ventilatory assist to a patient. A neuro-mechanical efficiency of the patient is determined. A control value is received at the mechanical ventilation system. The level of ventilatory assist to the patient is determined on the basis of the neuro-mechanical efficiency and of the control value. The mechanical ventilation system may be adjusted automatically based on the determined level of ventilatory assist to the patient. Alternatively, the determined level of ventilatory assist to the patient may be displayed for the benefit of an operator and a manual command may be received for adjusting the mechanical ventilation system.

Abstract: Some embodiments described herein may include a system or a method in which an air delivery lumen of an endotracheal tube, a laryngeal mask, or other airway device is configured to optionally provide a suction effect.

Abstract: A device to assist performing medical procedures that references anatomical landmarks through adjustable components to identify and stabilize a procedure site and provide guidance in performing the procedure. In one embodiment, an airway creation assist device (ACAD) can be dimensionally adjusted for different patient sizes and properly aligned using anatomical landmarks. The ACAD provides an adjustable template that enables accurate identification of the airway creation site, including but not limited to the cricothyroid membrane. The ACAD uses an insertion guide to guide the obturator and airway tube safely and consistently into the trachea, with a mechanical stop to prevent damaging the posterior trachea wall. The ACAD improves efficacy of the procedure, and makes perforating an incorrect airway creation procedure difficult. In another embodiment, a chest decompression assist device (DAD) Is disclosed for decompression treatment of air and/or fluid in the chest.

Abstract: A mouth seal assembly for use with a nasal mask system includes a mouth seal adapted to form a seal with the patient's mouth. The mouth seal is substantially independent from a supply of pressurized air from the nasal mask system. An anti-asphyxia valve may be provided to either the mouth seal over the patient's lips or the nasal mask system. A strap arrangement may support the mouth seal in a desired position on the patient's face in use.

Abstract: A wearable device (8,60,70,86) structured to exert a contact pressure between the wearable device and a skin surface of a wearer, such as a patient interface device for delivering a flow of breathing gas to a patient, includes a first member (18,72,96), such as a faceplate member, structured to have a first pressure applied thereto, a contact member (14,74), such as a sealing cushion, structured to exert the contact pressure against the skin surface in response to the first pressure, and a support member (20,62,78) positioned between the first member and the contact member, the support member including a plurality of compression members (40,52,54,64,84), wherein each of the compression members is structured to buckle in response to a compression force having at least a first predetermined level being applied to the support member.

Abstract: A mask system includes a cushion adapted to seal with a face of a patient. In one form an unobtrusive full-face masks system is provided which is comfortable and has a wide fit range. The cushion may include a sealing structure and a supporting structure. The supporting structure may include gaps or spacing in a nasal bridge region (NBR) and/or a lip region (CHN).

Abstract: A secretion trap for use between a patient connection and a patient circuit, the secretion trap including a first connection portion connectable to the patient connection for fluid communication with the patient connection, a second connection portion connectable to the patient circuit for fluid communication with the patient circuit, and a central portion located therebetween. The central portion having a first end portion in fluid communication with the first connection portion, a second end portion in fluid communication with the second connection portion, and a secretion collection well located between the first and second end portions sized to capture and retain secretions therein entering the central portion. The trap may include a drain in fluid communication with the secretion collection well for removal of secretions captured and retained by the secretion collection well.

Abstract: A closed-circuit heliox delivery system and methods for alleviating symptoms of COPD and related disorders are provided. The system is self-monitoring and can be used outside of a hospital environment. The system contains a gas supply fluidly connected to a breathing circuit. The breathing circuit contains an upper airway device, such as a mask. The system contains a sensor(s) and controller. The sensors measure parameters in the system, the ambient environment, or related to the physiological state of the user. The controller can adjust the system to maintain parameters within the device, i.e. pressure, temperature, humidity, within predetermined ranges. The controller can adjust the system to maintain a target physiological state of the user, i.e. target blood oxygen levels or Work of Breathing (WOB).

Abstract: Methods of an apparatus determine a quantity of a body of water in a humidifier such as by indirect measurement. The quantity of water may be determined by measuring one or more properties or characteristics, from which the quantity of water may be inferred. Characteristics of a flow of air, the humidifier, and/or the body of water may be measured. The characteristics may be, for example, pressure, flow rate, noise, vibration, temperature, electrical or mechanical. These may be measured by one or more sensors, which may be located in the humidifier, RPT device, air circuit or the patient interface. The methods described may have advantages, for example in being able to detect the quantity of water without requiring sensors to be present in a disposable component, and in some cases, without introduction of additional sensors.

Abstract: The present disclosure discloses a humidification device, and a humidifier and a ventilator to overcome deficiencies in the prior art such as the heating efficiency of a ventilator being relatively low when the amount of water in a humidification device is adequate. The humidification device comprises a heating area and a liquid conveying device conveying a liquid to the heating area, the liquid conveying device comprising a liquid inlet pipeline, the liquid inlet pipeline extending into the heating area and extending to a bottom of the heating area, and a reserved interval being provided between an outlet of the liquid inlet pipeline and the bottom of the heating area. According to the embodiments of the present disclosure it is ensured that the heating efficiency may be increased and the heating time may be reduced in the case of continuous use.

Abstract: Described are systems and methods for providing a pulse of a therapeutic gas with a desired flow profile to maximize therapeutic effectiveness. Systems and methods of the present disclosure can generate and/or provide desired flow profiles with various shapes and/or properties by configuring, modifying, optimizing, and/or factoring in aspects of at least one fixed flow rate assembly of a therapeutic gas delivery system such as, but not limited to, spatial relationships of elements of the fixed flow rate assembly, rate of valve closure and opening, latent flows, transient wave generation and/or propagation, to name a few.

Abstract: A urinary catheter assembly having a sleeve is provided. The urinary catheter assembly comprises a urinary catheter (2) having a hydrophilic surface; the urinary catheter being provided with an insertion tip (5) in a proximal insertion end of the urinary catheter and an outlet (4) at a distal end of the urinary catheter, a handle (8) being slidingly disposed on the urinary catheter, a collapsible, flexible sleeve (7) attached to the handle and being configured to cover the urinary catheter from the outlet to the tip portion in an extended configuration of the urinary catheter assembly, the sleeve being attached to a connector (9) at the outlet, the connector and handle configured to be detachably attached to each other and define a cavity provided by the sleeve, handle and connector encapsulating an entirety of the urinary catheter in a storage condition.

Abstract: An improved medical procedure or catheterization tray included in an improved medical procedure or catheterization package. The improved medical procedure or catheterization tray is intuitively arranged and includes instructions printed thereon to improve the medical procedure or catheterization implementation and results. In one example, a catheterization package and catheterization tray has a layout and/or arrangement of components that may help reduce CAUTI rates by facilitating ease of use and aiding in proper aseptic technique during insertion. The medical procedure or catheterization package and/or medical procedure or catheterization tray may include various implements, compartments, and components necessary and/or helpful to the medical procedure or catheterization, including, for example, improved swabs and an improved compartment for holding the swabs.

Abstract: The present disclosure provides an integrated medical device that includes a stiffening stylet for portions of a catheter along with attachment features for improved functionality and packaging of the catheter system.

Abstract: A multiple-lumen microcatheter tube has at least two tube lumens and a closed distal tube end. In the area of the distal tube end, a separation strip has between the two tube lumens at least one passage opening. There results a multiple-lumen tube, whose use as for example a probe for measuring tissue parameters, is improved.

Abstract: An introducing stylet is configured for insertion into an endotracheal tube (ETT) and includes an elongated rod having a distal end and a proximal end, and a positioning feature formed on the rod and configured to engage the ETT to prevent both longitudinal and lateral movement of the introducing stylet relative to the ETT. A portion of the distal end of the rod that extends longitudinally outwardly of the ETT and defines a leading end.

Abstract: Aspects of articulating devices and methods are disclosed. An exemplary articulating device may comprise an interior core with a reinforcing extending along a central axis, an exterior layer bonded to the interior core by an interface, and a lumen extending through the exterior layer, exterior of the reinforcing element, and parallel to the central axis. A steering wire may be moveable in the lumen to articulate a distal end of the device relative to the central axis in response to a force applied to the steering wire. Related methods of manufacturing an articulating device are also described.

Abstract: Described herein are bend-limited catheters (e.g., apparatuses, including devices and systems) and methods of using them.

Abstract: The present invention relates to a treatment kit comprising: a guide having a distal end and a proximal end; a position determination device for determining the position of the distal end of the guide in the body of a patient; and a catheter intended to be inserted into the body of the patient. The guide is graduated between its distal end and its proximal end, the graduations of the guide making it possible to measure a length of insertion of the guide into the body of the patient, and the catheter is adapted so as to be cut to a predetermined length that is determined based on the length of insertion.

Abstract: A medical device is provided that is configured to treat and drain an abscess. The device comprises a catheter having an expandable distal end including a flexible absorbent material. The catheter includes an input port configured to receiving fluid from a syringe, whereby the fluid expands distal end when injected. Upon expansion of the distal end, the absorbent material expands into the abscess cavity.

Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

Abstract: Fluid control devices, systems, and methods are useful for articulating catheters and other elongate flexible structures. A modular manifold architecture includes plate-mounted valves to facilitate fluid communication along a plurality of fluid channels included in one or more multi-lumen shafts for articulating actuators comprising balloons within a balloon array, with the balloons often mounted on two or more extruded multi-lumen shafts. Valve/plate modules can be assembled in an array, and a proximal interface of the shaft(s) may have ports for accessing the balloon channels distributed along an axis of the interface. By aligning and engaging the proximal interface with a receptacle that traverses the plates of the manifold assembly, the ports can be quickly and easily sealed to associated channels of the various valve/plate modules using a quick-disconnect fitting.

Abstract: Systems and methods and devices are provided for arresting or reversing the effects of myocardial remodeling and degeneration after cardiac injury, without the potential drawbacks associated with previously existing systems and methods, by at least partially occluding flow through the superior vena cava over multiple cardiac cycles, and more preferably, by adjusting the interval or degree of occlusion responsive to a sensed level of patient activity. In some embodiments, a controller is provided that actuates a drive mechanism responsive to a sensed level of patient activity to provide at least partial occlusion of the patient's superior vena cava, while a data transfer circuit of the controller provides bi-directional transfer of physiologic data to the patient's smartphone or tablet to permit display and review of such data.

Abstract: An apparatus includes an assembly and hollow templates. The assembly includes multiple hinges mounted thereon. The assembly is configured to rotate about a first axis, and each of the hinges is additionally configured to rotate about a respective second axis. The hollow templates are fitted on the respective hinges and are each configured to contain a balloon-based distal end of a medical instrument, each template having a patterned opening through which one or more electrodes are deposited on the distal end.

Abstract: A comprehensive multi-functional device platform that can be variably configured by clinician operators for patient-specific anatomies and clinical situations for treating complex and total occlusions is provided. This device platform enables physicians of any skill level to effectively treat the most challenging and complex lesions/occlusions more conveniently in less time. The Functionally Integratable Catheter System (“FICS System”) represents a system of “functional units” that can be configured together to operate synergistically, and comprises at least four main “functional units,” including: (a) FICS Support Catheter; (b) FICS Dilator; (c) FICS PTA Catheter; and (d) FICS Lock-Grip Handle. Each “functional unit” can be provided in a pre-assembled form by the manufacturer, intended to be configured into variable combinations by clinician operators.