Patents Issued in September 17, 2020
  • Publication number: 20200289668
    Abstract: Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules/moieties. The nanoparticle drug conjugates (NDCs) demonstrate imaging capability and targeting ligands which efficiently clear through the kidneys. Furthermore, the conjugates incorporate therapeutic agents for cancer detection, prevention, and/or treatment.
    Type: Application
    Filed: October 15, 2019
    Publication date: September 17, 2020
    Inventors: Michelle S. Bradbury, Barney Yoo, Ulrich Wiesner, Kai Ma
  • Publication number: 20200289669
    Abstract: Methods of editing target nucleic acids are provided using a guide RNA and a Cas9 protein to excise exons in a target gene and where the edited gene is expressed to produce a truncated polypeptide.
    Type: Application
    Filed: March 30, 2020
    Publication date: September 17, 2020
    Inventors: Amy J. Wagers, Mohammadsharif Tabebordbar, Wei Leong Chew, George M. Church
  • Publication number: 20200289670
    Abstract: Disclosed are adeno-associated virus (AAV) vectors comprising a nucleotide sequence encoding RP2 or RPGR-ORF15 and related pharmaceutical compositions. Also disclosed are methods of treating or preventing X-linked retinitis pigmentosa, increasing photoreceptor number in a retina of a mammal, and increasing visual acuity of a mammal using the vectors and pharmaceutical compositions.
    Type: Application
    Filed: April 21, 2020
    Publication date: September 17, 2020
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Zhijian Wu, Anand Swaroop, Suja Hiriyanna, Tiansen Li
  • Publication number: 20200289671
    Abstract: Provided is a pharmaceutical composition for preventing or treating neuronal diseases comprising, as an active ingredient, an exon 2-deleted AIMP2 variant (AIMP2-DX2) gene or a vector comprising the gene, and a method for treating neuronal diseases in animals other than humans, comprising administering the same to a subject in need of treatment. The pharmaceutical composition comprising, as an active ingredient, a AIMP2-DX2 gene or a vector comprising the gene has the effects of apoptosis inhibition, dyskinesia amelioration and oxidative stress inhibition and thus can be widely used for preventing and treating neuronal diseases such as Parkinson's disease and amyotrophic lateral sclerosis.
    Type: Application
    Filed: June 2, 2020
    Publication date: September 17, 2020
    Inventors: Jin Woo CHOI, Dong Uk LEE, Ki Hwan EUM
  • Publication number: 20200289672
    Abstract: The present disclosure provides, among other aspects, codon-altered polynucleotides encoding Factor VIII variants for expression in mammalian cells. In some embodiments, the disclosure also provides mammalian gene therapy vectors and methods for treating hemophilia A.
    Type: Application
    Filed: January 15, 2020
    Publication date: September 17, 2020
    Inventors: Hanspeter Rottensteiner, Friedrich Scheiflinger
  • Publication number: 20200289673
    Abstract: The present invention relates to vectors and compositions for the treatment of glycogen storage disease III.
    Type: Application
    Filed: March 9, 2018
    Publication date: September 17, 2020
    Inventors: FEDERICO MINGOZZI, GIUSEPPE RONZITTI, PATRICE VIDAL
  • Publication number: 20200289674
    Abstract: Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.
    Type: Application
    Filed: February 24, 2020
    Publication date: September 17, 2020
    Inventors: Albert Barnes Seymour, Seemin Seher Ahmed, Jason Boke Wright, Serena Nicole Dollive, Hillard Rubin
  • Publication number: 20200289675
    Abstract: Provided herein is a recombinant AAV (rAAV) comprising an AAV capsid and a vector genome packaged therein, wherein the vector genome comprises an AAV 5? inverted terminal repeat (ITR), an engineered nucleic acid sequence encoding a functional human N-acetyl-alpha-glucosaminidase (hNAGLU), a regulatory sequence which direct expression of hNAGLU in a target cell, and an AAV 3? ITR. Also provided is a pharmaceutical composition comprising a rAAV as described herein in a formulation buffer, and a method of treating a human subject diagnosed with MPS IIIB.
    Type: Application
    Filed: November 29, 2018
    Publication date: September 17, 2020
    Inventors: James M. Wilson, Christian Hinderer, Juliette HORDEAUX
  • Publication number: 20200289676
    Abstract: The design, synthesis, and functionalization of a conjugate including a tumor-targeting near-infrared (NIR) dye and a therapeutic agent and/or a diagnostic agent, whereby the NIR dye can function to target the therapeutic agent and/or diagnostic agent to tumor cells.
    Type: Application
    Filed: March 11, 2020
    Publication date: September 17, 2020
    Applicant: Lahjavida, LLC
    Inventors: Lyle D. Small, Ruizheng Wang, Shane M. Crippen
  • Publication number: 20200289677
    Abstract: The present disclosure provides activatable and detectable membrane-interacting peptides that, following activation, can interact with phospholipid bilayers, such as cell membranes. The present disclosure also provides methods of use of such compounds. The compounds of the present disclosure are of the general structure X1a-A-X2-Z-X1b, where A is a membrane-interacting peptide region having a plurality of nonpolar hydrophobic amino acid residues that, following separation from portions Z, is capable of interaction with a phospholipid bilayer; Z is an inhibitory peptide region that can inhibit the activity of portion A; X2 is a cleavable linker that can be cleaved to release cleavage products from the compound; and X1a and X1b are optionally-present chemical handles that facilitate conjugation of various cargo moieties to the compound. Prior to cleavage of the composition at X2, the composition acts as a promolecule that does not associate with cellular membranes to a significant or detectable level.
    Type: Application
    Filed: April 2, 2020
    Publication date: September 17, 2020
    Inventors: Michael Page, Charles S. Craik
  • Publication number: 20200289678
    Abstract: A composition containing (1) a porous material and (2) a polarization source for dynamic nuclear polarization containing a molecule capable of being in an excited triplet state. According to the composition, a dynamic nuclear polarization system that has a long spin-lattice relaxation time and can readily introduce the polarization object thereto can be provided.
    Type: Application
    Filed: October 25, 2018
    Publication date: September 17, 2020
    Inventors: Nobuhiro YANAI, Nobuo KIMIZUKA, Masanori HOSOYAMADA, Saiya FUJIWARA, Kenichiro TATEISHI, Tomohiro UESAKA
  • Publication number: 20200289679
    Abstract: One aspect of the invention provides a method for freeze-drying surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; partially submerging the vials in a chilled water bath, wherein the water bath has a sub-freezing temperature; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials. Another aspect of the invention provides a method for annealing surfactant-stabilized microbubbles. The method includes: preparing vials comprising a mixture comprising microbubbles; passing the vials in and out of liquid nitrogen (LN2) until the mixture is frozen; holding the vials at ?20° C.; placing the vials on a cooled shelf of a lyophilizer; freeze-drying the vials in the lyophilizer; and capping the freeze-dried vials.
    Type: Application
    Filed: March 13, 2020
    Publication date: September 17, 2020
    Inventors: Brian Edward Oeffinger, Margaret A. Wheatley, Rawan Shraim, Purva Vaidya, John Robert Eisenbrey
  • Publication number: 20200289680
    Abstract: A method of treating CNS tumors such as gliomas is provided comprising delivering a ?-emitting radionuclide containing composition to the tumor via the cerebral vasculature.
    Type: Application
    Filed: March 11, 2020
    Publication date: September 17, 2020
    Inventors: Matthew R. Dreher, Alexander Pasciak, Clifford Weiss
  • Publication number: 20200289681
    Abstract: Disinfecting particulate material includes combining the particulate material with a photocatalyst to yield a mixture, irradiating the mixture for a length of time with pulses from a light source having broadband emission spectrum between 190 nm-1100 nm to yield an irradiated mixture, and separating the photocatalyst from the disinfected mixture to yield the disinfected particulate matter. Irradiating the mixture inactivates microorganisms in the mixture to yield a disinfected mixture. A system for disinfecting particulate material includes a pulsed light source having a broadband emission spectrum in a range between about 190 nm and about 1100 nm, a chamber defining a cavity optically coupled to the pulsed light source, a humidifier, a fan, and one or more sensors. The chamber includes a conveyor configured to accept the particulate material and arranged such that the pulses emitted by the pulsed light source irradiate the particulate material on the conveyor.
    Type: Application
    Filed: March 13, 2020
    Publication date: September 17, 2020
    Inventors: Rongsheng Ruan, Yanling Cheng, Nan Zhou, Dongjie Chen, Peng Peng, Yunpu Wang, Renchuan Zhang, Charles Schiappacasse, Ling Chen
  • Publication number: 20200289682
    Abstract: A sterilization tray is disclosed herein. A medical instrument, such as an endoscope, may be placed into the sterilization tray, and the sterilization tray with the medical instrument disposed therein may be placed into a vacuum chamber of a sterilization system. The sterilization tray may also be used to transport the medical instrument to and from a point of care. Sterilization is performed with the instrument in the base component and the lid component disposed atop the base component. Transportation is performed with the instrument in the lid component and the base component disposed atop the lid component.
    Type: Application
    Filed: June 2, 2020
    Publication date: September 17, 2020
    Inventors: Samuel J. RHODES, Masood SIDDIQUI, Darius D. EGHBAL
  • Publication number: 20200289683
    Abstract: A lighting array including one or more antimicrobial light segments configured to emit light sufficient to inactivate one or more microorganisms at a target surface may be installed within identified contamination zones of food or beverage preparation, processing, storing or packaging equipment or machinery. In an ice machine, for example, an array controller is configured for communication with an ice machine controller to receive ice machine status information signals. The status information signals are usable by the array controller to determine cycle, state, and/or usage information associated with the ice machine. The array controller may individually control activation of the one or more antimicrobial light segments based on the status information signals received from the machine controller to achieve inactivation of one or more microorganisms on target surfaces within the machine.
    Type: Application
    Filed: March 13, 2020
    Publication date: September 17, 2020
    Inventors: Paul Dominic Christian, Paul R. Kraus, Gina McDowell, Amani Babekir, Anna Starobin
  • Publication number: 20200289684
    Abstract: A UV sterilization device for a board-type kitchenware includes a base with a driving member being received therein and defining a first motor, a left work-board, a right work-board, with a receiving room being formed between the left and right work-boards for receiving the board-type kitchenware therein, and a UV sterilization module connected to the first motor, longitudinally arranged on the inside of the left and right work-boards and horizontally sliding relative to the left and right work-boards. The first motor is configured to drive the UV sterilization module to slide so as to sterilize the board-type kitchenware received in the receiving room. The present structure not only can have a good disinfection and bactericidal effect on the harmful bacteria, pathogenic bacteria and molds left on the kitchenware with a minimize disinfection time, but also can reciprocate sterilization of the board-type kitchenware to achieve all-round sterilization by simple operation.
    Type: Application
    Filed: August 12, 2019
    Publication date: September 17, 2020
    Inventor: XIAOHUI LI
  • Publication number: 20200289685
    Abstract: A UV sterilization device for a container includes a housing, a base, a receiving room formed between the housing and the base, a transmission member symmetrically and rotatably mounted on the base and including a clamp for clamping the container, an extension rod symmetrically mounted on the base and inserting into the container to stretch out and draw back relative to the container along the axial direction of the extension member, a UV sterilization member mounted on the extension member to move with the extension member, and a driving member fixed with the base and including a motor therein. The motor is fixed with the transmission member and the extension member. The motor can drive the transmission member and the container to rotate, and drive the extension member to stretch out and draw back relative to the container along the axial direction of the extension member to further drive the UV sterilization member to disinfect the container.
    Type: Application
    Filed: August 12, 2019
    Publication date: September 17, 2020
    Inventor: Xiaohui Li
  • Publication number: 20200289686
    Abstract: An electrical device can include a sensor module that measures at least one parameter, where the at least one parameter is associated with determining the presence of a living being in a volume of space. The electrical device can also include a controller coupled to the sensor module, where the controller receives a measurement of the at least one parameter to determine whether the living being is in the volume of space. The electrical device can further include at least one ultraviolet (UV) light source coupled to the controller, which operates the at least one UV light source to emit UV light when the living being is not in the volume of space, and where the controller prevents the at least one UV light source from emitting the UV light when the living being is in the volume of space.
    Type: Application
    Filed: March 6, 2020
    Publication date: September 17, 2020
    Inventors: Raymond George Janik, Ethan Thomas Garrett
  • Publication number: 20200289687
    Abstract: Disclosed is an ultraviolet light sanitation device for retail checkout counter conveyor belts with a UV-C light source, a housing, and a mount. The UV-C light source is internally positioned at an apex end of the housing opposite a treatment opening of the housing, where a conveyor belt of a retail checkout counter is exposed to the UV-C light source through the treatment opening in order to sanitize the conveyor belt through germicidal irradiation by the UV-C light source. The mount connects the housing to a retail checkout counter such that the treatment opening is positioned adjacent to the conveyor belt, either adjacent to an underside of the conveyor belt within a conveyor cabinet of the retail checkout counter, or external to and atop the conveyor cabinet.
    Type: Application
    Filed: March 13, 2020
    Publication date: September 17, 2020
    Inventors: Kelsey Marie Riley, Daren Karl Brooks
  • Publication number: 20200289688
    Abstract: A method is for operating a UV sterilization device including a housing defining a cavity, and having a door configured to permit access to the cavity, and trays carried within the cavity. Each tray is configured to receive a mobile wireless communications device. The UV sterilization device may include UV CBAs carried within the cavity respectively adjacent the trays, each UV CBA having LED UV sources configured to irradiate the mobile wireless communications device with UV radiation. The UV sterilization device may include a controller, and the method may include operating the controller to selectively power one of the UV CBAs for disinfecting the mobile wireless communications device.
    Type: Application
    Filed: April 13, 2020
    Publication date: September 17, 2020
    Inventor: Christian DAVIS
  • Publication number: 20200289689
    Abstract: According to one implementation an apparatus for bacterially disinfecting a surface is provided. The apparatus includes a flexible body that contains therein at least one radially emitting optical fibers that is configured to emit bacterial disinfecting light. The radially emitting fibers having an axial and/or radial freedom of movement within a channel in which it is housed inside the flexible body such that when the flexible body changes shape the axial and/or radial freedom of movement reduces the amount of tensile stress applied along the length of the radially as compared to an amount of tensile stress that would otherwise be applied to the radially emitting fiber in an absence of the axial and/or radial freedom of movement of the radially emitting fiber inside the channel.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Inventor: Brett M. Zaborsky
  • Publication number: 20200289690
    Abstract: In an example, a method of operating a UV light source for a vehicle includes measuring an amount of power on a commodity power feeder, determining when the measured amount of power is greater than a threshold amount of power and, responsively, actuating a switch to a first state in which the switch decouples the UV light source from the power on the commodity power feeder. The method also includes determining when the measured amount of power is less than the threshold amount of power and responsively actuating the switch to a second state in which the switch couples the UV light source to the power on the commodity power feeder. The method also includes, while the switch is in the second state, activating the UV light source, using the power from the commodity power feeder, to emit UV light in the vehicle.
    Type: Application
    Filed: June 2, 2020
    Publication date: September 17, 2020
    Inventor: Kevin S. Callahan
  • Publication number: 20200289691
    Abstract: The present application relates to a method for disinfection of a temperature control device for human body temperature control during extracorporeal circulation which temperature control is conducted by use of a heat exchanger and a temperature control liquid circulating through the heat exchanger and the temperature control device. According to the present application, the temperature control device is connected to a temperature control liquid supply and, during operation of the temperature control device for human body temperature control, a disinfectant is selectively added to the temperature control liquid supply upstream of the temperature control device.
    Type: Application
    Filed: June 2, 2020
    Publication date: September 17, 2020
    Inventors: Johann Schreyer, Erwin Knott, Olivier Wolfgramm
  • Publication number: 20200289692
    Abstract: A method for reducing odor, by providing a colloidal dispersion of particles of silica having a particle size of from 3 nm to 100 nm, said particles having ions of one or more metals selected from copper, silver, zinc and iron adsorbed at the particle surface, and bringing at least one of said particles into contact with an odorous compound; and/or providing an aqueous silicate solution containing metal ions selected from ions of copper, silver, zinc and iron, and bringing at least one metal ion-carrying silicate particle formed in the solution into contact with an odorous compound. A composition for use in such a method and a product treated by such a composition.
    Type: Application
    Filed: December 21, 2018
    Publication date: September 17, 2020
    Inventor: Jan-Erik OTTERSTEDT
  • Publication number: 20200289693
    Abstract: A method and system are provided that include features for operating an appliance in an odor removal cycle. In one aspect, an appliance has a housing defining a sealable volume and includes an ozone generator, an ozone detection device, and a controller. In an odor removal cycle, the controller causes the ozone generator to inject, at a predetermined injection interval, predefined dosages of ozone into the sealable volume of the appliance. The controller monitors the concentration level within the sealable volume after each injection based on inputs received from the ozone detection device. The controller ascertains when the concentration level reaches a maximum concentration level threshold, and when this occurs, the controller can cease the injections and can activate one or more ozone removal devices to remove the ozone from the sealable volume to a safe level.
    Type: Application
    Filed: March 13, 2019
    Publication date: September 17, 2020
    Inventors: Je Kwon Yoon, JaeHyo Lee
  • Publication number: 20200289694
    Abstract: The present invention is directed to a digital aroma system that provides a scented air on demand. Fragrance cartridges are held in a fragrance module having a manifold and valves that are controlled by a processor. The system can open valves to direct an airflow through a selected fragrance cartridge in response to a user input or an automated control. The digital aroma system transmits fragrance information to a server which analyzes the fragrance consumption, user locations, and other user information to determine fragrance preferences and fragrance efficacy. The server provides fragrance formulation adjustments and fragrance recommendations to users computing devices.
    Type: Application
    Filed: January 21, 2020
    Publication date: September 17, 2020
    Applicant: INHALIO, INC.
    Inventor: Keith Kelsen
  • Publication number: 20200289695
    Abstract: A device for dispersing a fragrance by means of an electrical fan; the device includes a first half of a housing, a second half of a housing, and a fragrance-composition. The device is attachable to the electrical fan and is capable of dispensing scent when installed in front of the electrical fan.
    Type: Application
    Filed: March 13, 2019
    Publication date: September 17, 2020
    Inventor: Dustin McKinney
  • Publication number: 20200289696
    Abstract: A device for selectively providing an odor-rich environment includes a housing and a cover. The housing includes a central cavity and a plurality of chambers configured to store a predefined fragrance therein and having a respective outlet formed on an outer wall of the housing. The cover includes an exterior surface having at least one vent formed on the exterior surface. The exterior surface includes an interior sidewall and an exterior sidewall forming an inner chamber that slidably engages the housing such that the cover is configured to move between an open position and a closed position. Responsive to the cover being in the open position, the at least one vent is generally adjacent to the outlet of at least one of the plurality of chambers of the housing. The odor-rich environment can assist in preventing and/or treating postoperative delirium (POD) postoperative cognitive dysfunction (POCD), and/or pain in a subject.
    Type: Application
    Filed: March 8, 2017
    Publication date: September 17, 2020
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventor: Zhongcong Xie
  • Publication number: 20200289697
    Abstract: An antibacterial device that includes a substrate, a first electrode on the substrate, a second electrode on the substrate, and a protective layer covering the first electrode and the second electrode and having a first surface opposing of the substrate and a second surface opposite the first surface. Further, the first electrode and the second electrode are arranged such that the protective layer has an electric field strength on the second surface thereof of 150 kV/m or more when a voltage is applied to the first electrode or the second electrode.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Inventors: Masamichi Ando, Kenichiro Takumi, Daiji Tamakura, Kenichi Mori
  • Publication number: 20200289698
    Abstract: A ceiling-mounted decontamination unit with one or more internal decontamination sources, which may be UV-C emitters, inside a housing with a hingable panel for access to the internal space of the housing for maintenance and repairs, and one or more fans inside the housing that re-circulate the air in a room and subject the air to the germicidal internal decontamination source inside the housing, decontaminating the air passing through the ceiling-mounted decontamination unit's internal space and destroying viruses, bacteria, and other pathogens. The ceiling-mounted decontamination unit draws the air in from the room or area where the ceiling-mounted unit is installed, subjects the air to the internal decontamination source destroying pathogens, and returns the decontaminated air back to the same room or area from which the air is drawn. An optional luminaire or external decontamination source may be attached to the room- or area-facing exterior of the ceiling-mounted decontamination unit.
    Type: Application
    Filed: April 22, 2020
    Publication date: September 17, 2020
    Inventor: John Polidoro
  • Publication number: 20200289699
    Abstract: An aqueous ophthalmic solution comprising 0.00001 to about 10.0 percent by weight L-histidine, 1 ppm to 60 ppm hydrogen peroxide, 0.00001 to about 10.0 percent by weight of a B vitamin; and 0.1 to 500 parts per million of a preservative that provides superior preservative efficacy especially as against fungal microbes. These solutions may be employed in various ways including cleaning contact lenses, rinsing lenses while in the eye, storing lenses and in delivering active pharmaceutical agents to the eye.
    Type: Application
    Filed: March 13, 2019
    Publication date: September 17, 2020
    Inventor: Francis X. Smith
  • Publication number: 20200289700
    Abstract: A composition including a solution at least one acrylic adhesive and particles of a cross-linked polymer having a carboxylate-group density between 2.0 and 12.0 meq/g and an average pore size between 0.005 and 1.0 ?m, usable in particular for creating an adhesive matrix suitable for any device, for example for medical aims such as a patch, a film, a strip or a dressing, preferably a dressing, or suitable for any device of the functional textile type such as a sports item.
    Type: Application
    Filed: February 20, 2019
    Publication date: September 17, 2020
    Applicant: URGO RECHERCHE INNOVATION ET DEVELOPPEMENT
    Inventors: Anne-Sophie DANÉROL, Christelle GUILLAMAUD, Jean-Marc PERNOT
  • Publication number: 20200289701
    Abstract: A composition has an enzyme that is able to convert a substrate to release hydrogen peroxide; a substrate for the enzyme; and a superabsorbent component, such as a superabsorbent polymer. The composition is in the form of a powder and may form a gel on contact with water.
    Type: Application
    Filed: October 16, 2018
    Publication date: September 17, 2020
    Inventors: Thomas Hall, Sophie Constance Cox, Liam Michael Grover, David Kershaw
  • Publication number: 20200289702
    Abstract: Decellularized matrix microspheres comprising a polymeric material and a donor tissue are provided. Also disclosed are structures containing a plurality of decellularized matrix microspheres incorporating a first polymer and a donor tissue; and a second polymer, wherein the decellularized matrix microspheres and the second polymer are in the form of a filament. Methods of treating a tissue injury employing the matrix microspheres and structures described as well as their methods of manufacture are also provided.
    Type: Application
    Filed: October 26, 2018
    Publication date: September 17, 2020
    Inventors: Chia-Ying James Lin, Stacey Gruber, Patrick W. Whitlock, Paulomi Ghosh
  • Publication number: 20200289703
    Abstract: A bone-regeneration material that contains calcium phosphate particles in a biodegradable fiber containing PLGA by using electrospinning. A PLGA resin is heated in a kneader to soften until the viscosity of the resin becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is added and mixed with the softened PLGA resin, while the blade of the kneader rotates. The mixture is kneaded by applying thermal and mechanical energy to the mixture through the continuous rotation of the blade of the kneader in the heated state, and aggregations of the calcium phosphate fine particles are disintegrated to prepare a composite in which the calcium phosphate fine particles are dispersed in the PLGA resin. The composite is dissolved in a solvent to prepare a spinning solution. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.
    Type: Application
    Filed: April 3, 2020
    Publication date: September 17, 2020
    Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY, ORTHOREBIRTH CO., LTD.
    Inventors: Toshihiro Kasuga, Yasutoshi Nishikawa
  • Publication number: 20200289704
    Abstract: The invention is directed to a nerve cap for covering a nerve stump, comprising a tubular body with a closed end and an open end and essentially consisting of biodegradable polymeric material to prevent or treat symptoms caused by neuroma. The polymeric material preferably comprises a poly(DL-lactide-co-?-caprolactone) copolymer obtained by the copolymerizaton of DL-lactide and ?-caprolactone, which copolymer has a lactide content of 51-75 mol %.
    Type: Application
    Filed: May 8, 2020
    Publication date: September 17, 2020
    Inventors: Pieter van den Berg, Hans Wicher Kuijper, Leendert Willem Schwab, Mariëtta Johanna Olga Elizabeth Bertleff, Harmen Hendrikus de Vries
  • Publication number: 20200289705
    Abstract: The subject matter of the invention is an autopolymerisable 2-component prosthetic base material, a kit containing the material as well as a method for its production comprising at least one liquid monomer component (A), and at least one powdered component (B), wherein the prosthetic material in component (A) besides methylmethacrylate contains at least one N-alkyl-substituted acryloyloxy carbamate having a molecular mass of less than or equal to 250 g/mol, optionally at least one at least di-functional urethane (meth)acrylate, a di-, tri-, tetra- or multi-functional monomer not being urethane (meth)acrylate, and optionally polymeric particles having a primary particle size of less than 800 nm, and the powdered component (B) comprises polymeric particles having at least three different particle size fractions, and both (A) and (B) contains at least one initiator or at least one component of an initiator system for autopolymerisation.
    Type: Application
    Filed: November 11, 2016
    Publication date: September 17, 2020
    Applicant: KULZER GMBH
    Inventors: Alfred HOHMANN, Susanne BUSCH
  • Publication number: 20200289706
    Abstract: The present invention concerns a polyelectrolyte coating comprising at least one polycationic layer consisting of at least one polycation consisting of n repetitive units having the formula (1) and at least one polyanionic layer consisting of hyaluronic acid. The polyelectrolyte coating has a biocidal activity and the invention thus further refers to the use of said polyelectrolyte coating for producing a device, in particular a bacteriostatic medical device, more particularly an implantable device, comprising said polyelectrolyte coating, and a method for preparing said device and a kit.
    Type: Application
    Filed: November 2, 2018
    Publication date: September 17, 2020
    Inventors: Philippe LAVALLE, Pierre SCHAAF, Nihal Engin VRANA, Angela MUTSCHLER, Cynthia CALLIGARO, Lorène TALLET
  • Publication number: 20200289707
    Abstract: The present disclosure describes methods of treating a ligament injury with ligament grafting.
    Type: Application
    Filed: March 11, 2020
    Publication date: September 17, 2020
    Applicant: ARTHREX, INC.
    Inventors: David O. SHEPARD, Robert Harrison, Robert Benedict
  • Publication number: 20200289708
    Abstract: The present invention discloses the method of preparation and use of soft tissue membranous structures into slip resistant membranes with regularly spaced surface projections on one side and concave depressions on the other side with perforations or without perforations which enhance vascular ingrowth and tissue incorporation.
    Type: Application
    Filed: May 28, 2020
    Publication date: September 17, 2020
    Inventor: Theodore I. Malinin
  • Publication number: 20200289709
    Abstract: Described are methods for producing tissue constructs, tissue constructs produced by the methods, and their use. The described method of producing a tissue construct comprises providing a granular tissue, depositing one or more filaments on or in the granular tissue, each filament comprising an ink, and gelling or fusing the granular tissue, thereby producing the tissue construct.
    Type: Application
    Filed: September 20, 2018
    Publication date: September 17, 2020
    Inventors: Mark Skylar-Scott, Sebastien Uzel, Jennifer Lewis
  • Publication number: 20200289710
    Abstract: In alternative embodiments, provided are products of manufacture such as medical or dental devices, e.g., bone implants, having zinc phosphate (ZnP) coatings prepared on zinc (Zn), magnesium (Mg), and iron (Fe) based biodegradable metals and other non-biodegradable substrates, e.g., stainless steel, titanium and its alloys, cobalt-chrome alloys, nickel titanium alloys, to improve surface biocompatibility and provide antibacterial properties, and to enhance vascularization, and methods of making and using them. In alternative embodiments, also provided are methods to form ZnP coatings, including ZnP coatings with a porous surface, on metal surfaces such as zinc surfaces, and Zn-, Mg-, and Fe-based biodegradable metals, and other non-biodegradable substrates.
    Type: Application
    Filed: March 11, 2020
    Publication date: September 17, 2020
    Inventors: Donghui ZHU, Yingchao SU
  • Publication number: 20200289711
    Abstract: Methods for making an osteoimplant are provided. In one embodiment the method includes applying a mechanical force to an aqueous slurry of insoluble collagen fibers to entangle the insoluble collagen fibers so as to form a semi-solid mass of entangled insoluble collagen fibers; and lyophilizing the semi-solid mass of entangled collagen fibers to form the osteoimplant. An osteoimplant containing entangled insoluble collagen fibers is also provided.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Inventors: Scott M. Vickers, Jeffrey L. Scifert, Mirian Gillissen, Didier Billy
  • Publication number: 20200289712
    Abstract: Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.
    Type: Application
    Filed: April 29, 2019
    Publication date: September 17, 2020
    Applicant: University of Washington
    Inventors: Shaoyi Jiang, Tao Bai, Harihara Subramanian Sundaram, Andrew William Sinclair, Jean-René Ella-Menye, Priyesh Jain
  • Publication number: 20200289713
    Abstract: The present invention relates to an article fabrication system having a plurality of material deposition tools containing one or more materials useful in fabricating the article, and a material deposition device having a tool interface for receiving one of the material deposition tools. A system controller is operably connected to the material deposition device to control operation of the material deposition device. Also disclosed is a method of fabricating an article using the system of the invention and a method of fabricating a living three-dimensional structure.
    Type: Application
    Filed: May 26, 2020
    Publication date: September 17, 2020
    Inventors: Lawrence BONASSAR, Hod LIPSON, Daniel L. COHEN, Evan MALONE
  • Publication number: 20200289714
    Abstract: An implantable medical device is disclosed comprising a thermoplastic composite body having anterior, first lateral, second lateral, posterior, superior, and inferior surfaces, and at least one dense portion and at least one porous portion which are integrally formed. The at least one dense portion is formed of a first thermoplastic polymer matrix that is essentially non-porous, and which is continuous through a thickness dimension from the superior surface to the inferior surface. The at least one porous portion is formed of a porous thermoplastic polymer scaffold having a second thermoplastic polymer matrix which is continuous through the thickness dimension. A method for forming the thermoplastic composite body is disclosed comprising disposing a first powder mixture in a first portion of a mold, disposing a second powder mixture in a second portion of the mold, simultaneously molding the first powder mixture and the second powder mixture, and leaching porogen.
    Type: Application
    Filed: March 12, 2020
    Publication date: September 17, 2020
    Inventors: Douglas SNELL, Robert BALL, Ryan K. ROEDER
  • Publication number: 20200289715
    Abstract: A biocompatible soft tissue implant for introduction into a human body includes at least one layer comprising an elastomeric material, and at least one textile fabric arranged on the at least one layer comprising the elastomeric material. The at least one textile fabric forms a surface of the biocompatible soft tissue implant. The at least one textile fabric includes bioresorbable fibers which are embedded at least partially in the at least one layer comprising the elastomeric material.
    Type: Application
    Filed: October 26, 2018
    Publication date: September 17, 2020
    Inventors: Karl-Heinz Heffels, Denis Reibel, Dirk Grafahrend, Guenter Germann, Oliver Boegershausen
  • Publication number: 20200289716
    Abstract: A biocompatible composite material for complete or partial insertion into a human body includes at least one layer comprising an elastomeric material, and at least one textile fabric arranged on the at least one layer comprising the elastomeric material. The at least one textile fabric forms a surface of the biocompatible composite material. The at least one textile fabric includes bioresorbable fibers that are embedded at least partially in the at least one layer comprising the elastomeric material.
    Type: Application
    Filed: October 26, 2018
    Publication date: September 17, 2020
    Inventors: Karl-Heinz Heffels, Denis Reibel, Dirk Grafahrend, Alexandra Kaul, Yosuke Kadomae, Guenter Germann
  • Publication number: 20200289717
    Abstract: A processing technique for creating nanowires and hierarchically porous micro/nano structures of ceramic materials is provided. The process includes evaporation of micron-sized water droplets containing dissolved organic salts on heated substrates followed by thermal decomposition of the deposited material. The micron-sized droplets may be generated by supercritical CO2 assisted nebulization, in which high-pressure streams of aqueous solution and supercritical CO2 are mixed, followed by controlled depressurization through a fine capillary. Rapid evaporation takes place on the heated substrates and structures are generated due to CO2 effervescence from the droplets and evaporation of water, along with the pinning of the three phase contact line. Depending on the mass deposited, a mesh of nano-wires or membrane-like structures may result. Sintering of the membrane-like scaffolds above the decomposition temperature of the organic salt creates nanopores within the structures, creating a dual hierarchy of pores.
    Type: Application
    Filed: February 10, 2020
    Publication date: September 17, 2020
    Inventors: Sachin KHAPLI, Ramesh JAGANNATHAN