Patents Issued in September 17, 2020
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Publication number: 20200291118Abstract: The present invention provides a recombinant protein. The recombinant protein includes an anti-PD-1 antibody and human SIRPA extracellular domain. The N-terminus of the human SIRPA extracellular domain is linked to the C-terminus of the heavy chain of the anti-PD-1 antibody.Type: ApplicationFiled: June 4, 2020Publication date: September 17, 2020Inventors: Ying Huang, Faming ZHANG, Gan Xi
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Publication number: 20200291119Abstract: The present application relates to anti-PD-L1 antibodies and their use to detect PD-L1 in a sample from a subject. In some embodiments, the subject has been treated with a therapeutic anti-PD-L1 antibody and an anti-PD-L1 described herein does not compete for binding to PD-L1 with the therapeutic anti-PD-L1 antibody. In some embodiments, the anti-PD-L1 antibody is linked to a N detectable moiety, such as a fluorophore and the anti-PD-L1 antibody is used to detect PD-L1 in a subject using flow cytometry.Type: ApplicationFiled: May 27, 2020Publication date: September 17, 2020Applicant: Genentech, Inc.Inventors: Doris KIM, Terence WONG, Anan CHUNTHARAPAI, Cherie Louise GREEN
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Publication number: 20200291120Abstract: The present disclosure relates to novel anti-CLEC2D antibodies and related compositions and methods of use thereof. These antibodies are used as therapeutics, and in prognostic and diagnostic applications in various cancers and other diseases.Type: ApplicationFiled: February 10, 2020Publication date: September 17, 2020Inventors: Kavitha Iyer RODRIGUES, Maloy GHOSH, Sunit MAITY, Yogendra Manjunath Bangalore MUNIRAJU, Sathyabalan MURUGESAN, Sanghamitra BHATTACHARJEE, Vivek HALAN, Subhra Prakash CHAKRABARTY, Ashvini Kumar DUBEY, Anurag TIWARI, Kirthana Mysore Vasudevarao SINDHE, Pallavi LAHIRI, Sahana Bhima RAO, Prachi, Shruti SRIVASTAVA, Rao Shreesha RAMESH, Bharath Ravindra SHENOY, Nikitha MARKANDA, Bhagyashree DIKEY, Bairavabalakumar NATARAJAN
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Publication number: 20200291121Abstract: The present invention relates to biotechnology and provides antibodies that specifically bind to IL-5R?. The invention also relates to DNA encoding said antibodies, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibodies.Type: ApplicationFiled: October 2, 2018Publication date: September 17, 2020Inventors: Ekaterina Vladimirovna SOFRONOVA, Aleksei Konstantinovich MISORIN, Aleksandr Nikolaevich DORONIN, Timofey Aleksandrovich NEMANKIN, Aleksandra Aleksandrovna SOZONOVA, Galina Stepanovna ZHIRIVSKAIA, Sergey Aleksandrovich LEGOTSKY, Anna Konstantinovna VLADIMIROVA, Alina Valerevna BELIASNIKOVA, Mariia Aleksandrovna SHCHEMELEVA, Pavel Andreevich IAKOVLEV, Valery Vladimirovich SOLOVYEV, Elena Andreevna KRENDELEVA, Natalia Evgenevna PESTOVA, Dmitry Valentinovich MOROZOV
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Publication number: 20200291122Abstract: Provided herein are methods for treating cancer, comprising administering to a subject having cancer a therapeutically effective amount of an anti-GITR antibody alone or together with an anti-PD-1 or anti-PD-L1 antibody.Type: ApplicationFiled: May 15, 2018Publication date: September 17, 2020Inventors: Suba KRISHNAN, Penny E. PHILLIPS, Zheng YANG, Haiqing WANG
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Publication number: 20200291123Abstract: The present invention relates to novel anti-CD40 antibodies and a use thereof and, more specifically, provided are a pharmaceutical composition for treating or preventing autoimmune diseases and a composition for inhibiting immune rejection during organ transplantation, both compositions containing, as an active ingredient, novel anti-CD40 antibodies that specifically bind to a novel epitope of CD40. Novel anti-CD40 antibodies of the present invention directly target CD40, but not CD40 ligands, and block the signaling of CD40-CD154 without stimulating platelets so as to exhibit excellent antagonistic effects, thereby being expected to be usable as a preparation effective in the treatment of autoimmune diseases and the inhibition of organ transplantation rejection.Type: ApplicationFiled: June 1, 2018Publication date: September 17, 2020Inventors: Chung Gyu Park, Jung Sik Kim
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Publication number: 20200291124Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.Type: ApplicationFiled: May 11, 2020Publication date: September 17, 2020Inventors: Simone OOSTINDIE, Frank BEURSKENS, Esther BREIJ, Edward VAN DEN BRINK, Andreas HOLLENSTEIN, Marije OVERDIJK, Margaret LINDORFER, Ronald TAYLOR, Paul PARREN, Hilma VAN DER HORST, Martine E.D. CHAMULEAU, Tuna MUTIS
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Publication number: 20200291125Abstract: This disclosure describes chimeric antigen receptors for expression in a Natural Killer (NK) cell, pharmaceutical compositions that include NK cells (and/or iPSCs) modified to express a chimeric antigen receptor, and methods involving such chimeric antigen receptors. Generally, the chimeric antigen receptor includes an ectodomain that includes an antigen recognition region, a transmembrane domain linked to the ectodomain, and an endodomain linked to the transmembrane domain. The endodomain can include a signaling peptide that activates an NK cell.Type: ApplicationFiled: April 1, 2020Publication date: September 17, 2020Inventors: Dan Samuel KAUFMAN, David Lee LAMPI HERMANSON, Branden Scott MORIARITY
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Publication number: 20200291126Abstract: Provided are antibodies and antigen-binding fragment thereof that bind to VSIG4. Various in vitro and in vivo methods and compositions related to antibodies. Methods include prevention and/or therapeutic treatment of cancer using an antibody or an antigen-binding fragment that binds to VSIG4.Type: ApplicationFiled: April 2, 2020Publication date: September 17, 2020Inventors: Byoung S. Kwon, Hye Jeong Kim, Sunhee Hwang, Joongwon Lee, Seung Hyun Lee, Sun Woo Im, Jin Kyung Choi, Hyun Tae Son, Hyeok-Jun Park
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Publication number: 20200291127Abstract: Disclosed herein are methods and compositions for targeting a complex comprising a neoantigen presenting protein and a neoantigen in cancer. Further disclosed herein are antibodies that selectively bind to a complex comprising a neoantigen presenting protein and a neoantigen, as well as methods of use thereof.Type: ApplicationFiled: May 18, 2020Publication date: September 17, 2020Inventor: Jon WEIDANZ
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Publication number: 20200291128Abstract: Disclosed herein are methods and compositions for targeting a complex comprising a neoantigen presenting protein and a neoantigen in cancer. Further disclosed herein are antibodies that selectively bind to a complex comprising a neoantigen presenting protein and a neoantigen, as well as methods of use thereof.Type: ApplicationFiled: May 18, 2020Publication date: September 17, 2020Inventor: Jon WEIDANZ
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Publication number: 20200291129Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.Type: ApplicationFiled: January 21, 2020Publication date: September 17, 2020Inventors: Steve RUBEN, Tao HE, Candy LEE, Karen VAN ORDEN, Paul MOORE
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Publication number: 20200291130Abstract: The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies for the treatment of ErbB-2/ErbB-3 positive tumor. More in particular it relates to treating tumors with a high ErbB-2/ErbB-3 cell-surface receptor ratio. Also encompassed are methods for treating patients not previously treated with an ErbB-2 specific therapy or with an ErbB-3 specific therapy.Type: ApplicationFiled: April 3, 2018Publication date: September 17, 2020Inventors: Mark THROSBY, Cecillia Anna Wilhelmina GEUIJEN, David Andre Baptiste MAUSSANG-DETAILLE, Ton LOGTENBERG
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Publication number: 20200291131Abstract: The present invention relates to bispecific HER2 antibodies, novel HER2 antibody variants, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.Type: ApplicationFiled: January 16, 2020Publication date: September 17, 2020Applicant: Hoffmann-La Roche Inc.Inventors: Rebecca Croasdale-Wood, Lydia Jasmin Hanisch, Guy Georges, Thomas Hofer, Ralf Hosse, Christian Klein, Ekkehard Moessner, Samuel Moser, Wolfgang Schaefer, Juergen Michael Schanzer, Werner Scheuer, Claudio Sustmann, Pablo Umana
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Publication number: 20200291132Abstract: Inhibition of human epidermal growth factor receptor 2, human epidermal growth factor receptor 3, or of the heterodimerization of these proteins has presently been found to mitigate mechanically-induced lung injury or a lung-stretch injury. Provided are methods for treating a mechanically-induced lung injury or a lung-stretch injury, for increasing lung compliance, moderating alveolar epithelial permeability, or both in a subject having a mechanically-induced lung injury or a lung-stretch injury, for protecting a subject against a decrease in lung compliance, an increase in alveolar epithelial permeability, or both, as a result of a mechanically-induced lung injury or a lung-stretch injury, such methods involving the administration of an inhibitor of human epidermal growth factor receptor 2 (HER2) or human epidermal growth factor receptor 3 (HER3), or an inhibitor of the heterodimerization of HER2/HER3.Type: ApplicationFiled: May 28, 2020Publication date: September 17, 2020Inventors: Susan S. Margulies, Nadir YEHYA
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Publication number: 20200291133Abstract: The present disclosure concerns antibodies and antibody fragments binding to citrullinated proteins (ACPA), and their use in prevention and treatment of autoimmune diseases, specifically rheumatoid arthritis (RA).Type: ApplicationFiled: November 22, 2018Publication date: September 17, 2020Applicant: VACARA ABInventors: Rikard HOLMDAHL, Theo RISPENS, Bingze XU, Changrong GE
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Publication number: 20200291134Abstract: The present invention features methods and compositions for the generation and use of conformation-specific antibodies or fragments thereof.Type: ApplicationFiled: December 12, 2019Publication date: September 17, 2020Inventors: Kun Ping LU, Xiao Zhen ZHOU
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Publication number: 20200291135Abstract: The present disclosure provides antibodies (e.g., humanized antibodies) that specifically bind to Mer Tyrosine Kinase (MERTK; e.g., human MERTK) and compositions comprising such antibodies. The present disclosure also provides antibody-drug conjugates comprising (i) an anti-MERTK antibody or antigen-binding fragment thereof described herein that specifically binds to MERTK (e.g., human MERTK), and (ii) cytotoxic agents conjugated directly to the antibodies or conjugated to the antibodies via linkers, and compositions comprising such antibody-drug conjugates. The present disclosure also provides methods for treating cancer, comprising administering to a human subject in need thereof (a) an anti-MERTK antibody that specifically binds to MERTK (e.g., human MERTK) or an antigen-binding fragment thereof described herein, or (b) an antibody-drug conjugate that comprises (i) an anti-MERTK antibody or antigen-binding fragment thereof that specifically binds to MERTK (e.g.Type: ApplicationFiled: February 25, 2020Publication date: September 17, 2020Applicant: Rgenix, Inc.Inventors: Masoud Tavazoie, Isabel Kurth, Shugaku Takeda, Celia Andreu-Agullo, Ivo Lorenz
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Publication number: 20200291136Abstract: It provides methods and pharmaceutical compositions comprising antagonists to the protein Bile Salt-Stimulated Lipase (BSSL) for the prevention, prophylaxis and treatment of inflammatory diseases, such as rheumatoid arthritis. It further relates to pharmaceutical compositions comprising BSSL antagonists and their use in methods for the prevention, prophylaxis and treatment of inflammatory diseases, such as rheumatoid arthritis. Suitable BSSL antagonists to be used according to the invention are BSSL antibodies.Type: ApplicationFiled: May 29, 2020Publication date: September 17, 2020Inventors: Olle Hernell, Susanne Lindquist, Lennart Gustav Lundberg
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Publication number: 20200291137Abstract: Thermoplastic starch materials and methods of making the same are provided. The methods involve mixing a starch material, plasticizer and water in a low-shear mixer under conditions that will result in substantial gelatinization of the starch material. The melt formed within the mixer is discharged into an extruder for final processing. The methods prevent degradation of the starch material thereby resulting in the formation of a thermoplastic starch material having high strength, due at least in part to the preservation of the molecular weight characteristics of the starch, and improved elasticity due the ability to use higher water contents than conventional processes.Type: ApplicationFiled: March 13, 2020Publication date: September 17, 2020Inventors: Mark Remmert, Mike Parker
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Publication number: 20200291138Abstract: The present invention concerns an improved process for biorefinery of brown macroalgae, which comprises: (a) contacting the brown macroalgae with a solvent system comprising at least 30 wt % organic solvent, to obtain extracted macroalgae as solid residue and a liquor; and (b) biorefining the extracted macroalgae. The inventors have found that the contacting of step (a) results in an efficient and cost-effective dewatering of the macroalgae, wherein up to 95 wt % of the internal moisture of the macroalgae could be lost without the need for energy-consuming drying techniques. As such, the downstream biorefinery of the extracted macroalgae is greatly facilitated.Type: ApplicationFiled: November 21, 2018Publication date: September 17, 2020Applicant: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNOInventors: Adrianus Theodorus Smit, Wouter Johannes Joseph Huijgen
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Publication number: 20200291139Abstract: Compounds of general formulae 6 and 13 where X is —NH—C(NH2)?N+H2 or —N+H3, Y is a linear oligomer of arginine units terminated with an aminodimethylenamide unit (—Arg)n—NH—(CH2)2—NH2, where n=6-10, or arginine-aminocaproic units (—Arg—Aca)n—NH2, where n=6 to 10, A—?CF3COO— or Cl— and m=1-2. Preparation and use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membranes for the purpose of incorporation of modified nucleoside triphosphates into cellular DNA or RNA. Use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membrane for determining the virostatic activities of modified nucleoside triphosphates. Use of compounds of general formula 6 and 13 as carriers of modified nucleoside triphosphates across the cell membrane for determining cell proliferation and S phase of the cell cycle.Type: ApplicationFiled: March 15, 2017Publication date: September 17, 2020Applicant: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.Inventors: Tomas KRAUS, Zbigniew ZAWADA
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Publication number: 20200291140Abstract: A flexible manufacturing system for selectively producing different alpha-olefins from ethylene includes: (a) a reaction section 18 with ethylene feed operative to oligomerize ethylene; (b) a catalyst feed system 12, 14, 16 comprising a plurality of independent homogeneous catalyst feeders connected with the reaction section for alternatively providing different selective homogeneous catalyst compositions to the reaction section; (c) an ethylene recycle column 22 coupled to the reaction section and adapted to receive crude product and unreacted ethylene therefrom, the recycle column being operative to separate ethylene and optionally lower oligomers from the crude product which are recycled to the ethylene feed to the reaction section, the ethylene recycle column being further operative to provide a crude product bottoms stream; (d) a catalyst removal section 20 coupled to the reaction section adapted to remove spent catalyst from the system; and (e) a first product separation column 24 connected to the recycType: ApplicationFiled: February 28, 2020Publication date: September 17, 2020Inventors: Michael O. Nutt, Baiyi Zhao
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Publication number: 20200291141Abstract: A process is provided for the polymerization of fluoromonomer to an dispersion of fluoropolymer particles in an aqueous medium in a polymerization reactor, by (a) providing the aqueous medium in the reactor, (b) adding the fluoromonomer to the reactor, (c) adding initiator to the aqueous medium, the combination of steps (b) and (c) being carried out essentially free of hydrocarbon-containing surfactant and resulting in the kickoff of the polymerization of the fluoromonomer, and (d) metering hydrocarbon-containing surfactant into the aqueous medium after the kickoff of polymerization, e.g. after the concentration of the fluoropolymer in the aqueous medium is at least 0.6 wt %, the metering being at a rate reducing the telogenic activity of said surfactant while maintaining surface activity.Type: ApplicationFiled: June 1, 2020Publication date: September 17, 2020Applicant: THE CHEMOURS COMPANY FC, LLCInventors: PAUL DOUGLAS BROTHERS, SUBHASH VISHNU GANGAL, DIPTI DILIP KHASNIS
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Publication number: 20200291142Abstract: A process for preparing a (meth)acrylate comprising preparing an aqueous phase by combining water, one or more stabilizing agents, and one or more surfactants; preparing an oil phase by combining one or more free radical initiators, one or more monomers capable of undergoing radical polymerization, one or more crosslinking and/or graft-linking monomers, and stearyl methacrylate and/or lauryl methacrylate, wherein the free radical initiator is capable of partitioning preferentially into the oil phase; combining the aqueous and oil phases and mixing to form a suspension having oil droplets ranging in size from 1 to 10 microns; raising the temperature of the suspension to effect an initial polymerization forming a core polymer is provided.Type: ApplicationFiled: June 1, 2020Publication date: September 17, 2020Inventors: Carlos A. Cruz, Morris C. Wills
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Publication number: 20200291143Abstract: An olefin polymerisation method and arrangement comprising polymerising at least one olefin in gas phase in a fluidised bed in the presence of an olefin polymerisation catalyst in a polymerisation reactor having a vertical body; a generally conical downwards tapering bottom zone; a generally cylindrical middle zone, above and connected to said bottom zone; and a generally conical upwards tapering top zone above and connected to said middle zone wherein (i) fluidisation gas is introduced to the bottom zone of the reactor from where it passes upwards through the reactor; (ii) the fluidisation gas is withdrawn from the top zone of the reactor; (iii) a fluidised bed is formed within the reactor where the growing polymer particles are suspended in the upwards rising gas stream; and wherein the polymerisation reactor has an operating temperature set point and which reactor comprises at least one temperature measurement sensor, wherein a temperature difference (DT) between the temperature measurement sensor (Tm), anType: ApplicationFiled: June 15, 2018Publication date: September 17, 2020Inventors: Apostolos Krallis, Vasileios Kanellopoulos
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Publication number: 20200291144Abstract: Described herein is a polymer comprising: interpolymerized units of (i) a fluorinated terminal alkene monomer and (ii) a tertiary amine-containing fluorinated monomer comprising at least one of a vinyl amine, a substituted vinyl amine, an allyl amine, a substituted allyl amine, and combinations thereof, wherein the polymer can be amorphous or semi-crystalline with a melting point no greater than 325° C. Dispersions thereof and methods of making and using the same are also described.Type: ApplicationFiled: June 2, 2020Publication date: September 17, 2020Inventors: Michael J. Bulinski, Michael G. Costello, Denis Duchesne, Klaus Hintzer, William M. Lamanna, Kai H. Lochhaas, Michael J. Parent, Sean M. Smith
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Publication number: 20200291145Abstract: A polymer compound having a weight average molecular weight in the range of 1,000 to 500,000, and contains one or more repeating units represented by formula (1) and one or more repeating units represented by formula (2): R1 represents a hydrogen atom or a methyl group; Rf1 represents a linear or branched alkyl group having 1 to 4 carbon atoms or a phenyl group, and has at least one fluorine atom or a trifluoromethyl group in Rf1; Z1 represents a single bond, an arylene group having 6 to 12 carbon atoms or —C(?O)—O—R2—; R2 represents a linear, branched or cyclic alkylene group having 1 to 12 carbon atoms, an arylene group having 6 to 10 carbon atoms or an alkenylene group having 2 to 10 carbon atoms, and may have an ether group, a carbonyl group or an ester group in R2; and “a” is 0<a?1.0, and “b” is 0<b<1.0.Type: ApplicationFiled: May 29, 2020Publication date: September 17, 2020Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Jun HATAKEYAMA, Takayuki FUJIWARA, Koji HASEGAWA, Takayuki NAGASAWA
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Publication number: 20200291146Abstract: A method may include polymerizing ethylene in a tubular reactor, where the polymerization is substantially free of a chain transfer agent. A method may include polymerizing ethylene in a tubular reactor, the ethylene having a specific delivery pressure and the polymerization having one or more specific peak temperatures. The molecular weight of the resulting polyethylene may be controlled by the selection of the delivery pressure and the one or more peak temperatures.Type: ApplicationFiled: March 16, 2020Publication date: September 17, 2020Applicant: Braskem S.A.Inventors: Eduardo José Dotti, Omar Wandir Renck, Roger Ribeiro Malmegrim, Marcelo Farah, Antonio Marchi Netto, Cid Miro, Jorge Manuel Jardim da Silva
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Publication number: 20200291147Abstract: The invention pertains to a polyunsaturated compound having formula (I) [compound (DAIC-PFPE)]: TA-O—Rf-TA? wherein: —Rf is (per)fluoropolyoxyalkylene chain [chain (Rf)] comprising recurring units having at least one catenary ether bond and Sat least one fluorocarbon moiety; TA and TA?, equal to or different from each other, are selected from the group consisting of: (i) C1-C24 (hydro)(fluoro)carbon groups, possibly comprising one or more than one of H, O, and Cl; and (ii) (hydro)(fluoro)carbon group comprising at least one diallylisocyanurate group of formula (A) wherein each of R1, R2, R3, R4, R5, and R6 is, independently, a hydrogen atom or a C1-C3 hydrocarbon group, preferably a hydrogen atom (group TDAIC), with the provisio that at least one of TA and TA? is a group TDAIC, to a process for its manufacture and its use for curing fluoroelastomers, to fluoroelastomer compositions comprising the same, as well as to a process for producing fluororubber mouldings therefrom.Type: ApplicationFiled: February 28, 2017Publication date: September 17, 2020Inventors: Stefano BOSSOLO, Ivan Diego WLASSICS, Liubov CHERNYSHEVA, Davide VICINO
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Publication number: 20200291148Abstract: The present invention provides a method for preparing a transition metal complex, including a step of preparing a dispersion including a transition metal salt or alkoxide, and a coordinating solvent; and a step of reacting an organic borate-based compound containing a carbon-based, silyl-based or amine-based cation and a borate-based bulky anion, with the dispersion, wherein the transition metal is one or more selected from the metals in group 7 to group 12.Type: ApplicationFiled: March 21, 2019Publication date: September 17, 2020Applicant: LG Chem, Ltd.Inventors: Gyeong Shin Choi, Dong Hyun Jo, Hyun Taek Oh, Won Hee Kim, Seung Young Park
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Publication number: 20200291149Abstract: A process for producing polyethylene polymers including contacting ethylene and at least one C3 to C8 alpha-olefin comonomer with a polymerization catalyst on a particulate support in a fluidized bed polymerization reactor under conditions effective to polymerize at least part of the ethylene and comonomer and produce the polyethylene polymers, wherein the support has a d10 particle size as measured by laser diffraction of at least 18 microns, is provided.Type: ApplicationFiled: February 7, 2018Publication date: September 17, 2020Inventors: Corrine L. Brandl, William A. Lamberti, Charles R. Buhler, Judson S. Clements, Harry W. Deckman, Joseph Moebus, Marc L. DeChellis
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Publication number: 20200291150Abstract: The present invention relates to a novel metallocene catalyst compound for the production of a polyolefin resin having a high molecular weight and a wide molecular weight distribution or a method of preparing the same, and more particularly to a metallocene catalyst compound using a ligand containing a Group 15 or 16 element having a bulky substituent or a method of preparing the same. The present invention provides a novel metallocene catalyst compound represented by Chemical Formula 1 below.Type: ApplicationFiled: February 26, 2020Publication date: September 17, 2020Applicant: DAELIM INDUSTRIAL CO., LTD.Inventors: Seung Tack YU, Yong KIM, Dong Sik PARK, Yong Jae JUN
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Publication number: 20200291151Abstract: A method of producing a heat-resistant crosslinked fluororubber formed body, including a step (1) of melt-mixing, with respect to 100 mass parts of base rubber containing 40 to 98 mass % of fluororubber and 2 to 40 mass % of ethylene/tetrafluoroethylene copolymer resin, 0.003 to 0.5 mass parts of organic peroxide, 0.5 to 400 mass parts of inorganic filler, 2 to 15 mass parts of a specific silane coupling agent, and silanol condensation catalyst, and including a step (a) of melt-mixing a part of the base rubber, the organic peroxide, the inorganic filler and the silane coupling agent at a temperature equal to or higher than a decomposition temperature of said organic peroxide, and a step (b) of melt-mixing a remainder of the base rubber, and the silanol condensation catalyst, and the fluororubber and the ethylene/tetrafluoroethylene copolymer resin are melt-mixed in any of the steps (a) and (b).Type: ApplicationFiled: May 28, 2020Publication date: September 17, 2020Applicant: FURUKAWA ELECTRIC CO., LTD.Inventors: Hiroki CHIBA, Masaki NISHIGUCHI, Arifumi MATSUMURA
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Publication number: 20200291152Abstract: The invention relates to the field of preparing aqueous dispersions of organic, organometallic or inorganic particles. In particular, the invention relates to the preparation of aqueous suspensions comprising organic, organometallic or inorganic particles and at least one particular copolymer obtained by polymerization of at least one acid and at least one compound or at least one ester derived from a particular acid, in the presence of water, at least one initiator compound and at least one activator compound, followed by total or partial neutralization by means of at least one compound chosen from alkali metal hydroxides, alkaline earth metal hydroxides, alkaline earth metal dihydroxides and mixtures thereof. The invention relates to such a particular copolymer having a low polydispersity index and weight-average molecular weight, the preparation process thereof and the use thereof, especially for the preparation of an aqueous paint composition.Type: ApplicationFiled: March 29, 2017Publication date: September 17, 2020Applicant: COATEXInventors: Mehdi BOUZID, Clementine CHAMPAGNE, Benoit MAGNY, Jean-Marc SUAU
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Publication number: 20200291153Abstract: The present invention provides a carboxyl group-containing copolymer having a better calcium ion trapping ability and a better carbon black dispersing ability than any conventional carboxyl group-containing copolymers. The present invention relates to a carboxyl group-containing copolymer including a structural unit (a) derived from an unsaturated monocarboxylic acid monomer (A), a structural unit (b) derived from an unsaturated dicarboxylic acid monomer (B), and a structural unit (c) derived from a cationic monomer (C).Type: ApplicationFiled: November 22, 2017Publication date: September 17, 2020Inventors: Hikaru TAKAHASHI, Ryosuke TAKECHI, Yasuhiro ONO
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Publication number: 20200291154Abstract: The invention relates to an acrylic formulation having an acrylic matrix and 1-20 percent by weight of a very high molecular weight acrylic processing aid, with a weight average molecular weight of greater than 5,000,000 Daltons. The formulation has a high melt strength, yet is processable under typical melt processing conditions. The formulation is useful for melt-processed products, including extruded products such as extruded sheet, foam, co-extruded profiles, blown films, and other objects typically formed by a heat processing operation. Useful acrylic matrices include Plexiglas® and Solarkote® resins from Arkema Inc.Type: ApplicationFiled: March 24, 2017Publication date: September 17, 2020Inventor: Zeena Cherian
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Publication number: 20200291155Abstract: According to one embodiment, a pattern forming material is disclosed. The pattern forming material contains a polymer. The polymer includes a specific first monomer unit. The monomer unit has a structure having ester of a carboxyl group at a terminal of a side chain. In the ester, a carbon atom bonded to an oxygen atom next to a carbonyl group is a primary carbon, a secondary carbon or a tertiary carbon. The pattern forming material is used for manufacturing a composite film as a mask pattern for processing a target film on a substrate. The composite film is formed by a process including, forming an organic film on the target film with the pattern forming material, patterning the organic film, and forming the composite film by infiltering a metal compound into the patterned organic film.Type: ApplicationFiled: September 6, 2019Publication date: September 17, 2020Applicant: TOSHIBA MEMORY CORPORATIONInventors: Norikatsu SASAO, Koji ASAKAWA, Shinobu SUGIMURA
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Publication number: 20200291156Abstract: According to one embodiment, a polymer material is disclosed. The polymer material contains a polymer. The polymer contains a first monomer unit having a lone pair and an aromatic ring at a side chain, and a second monomer unit including a crosslinking group at a terminal of the side chain, with its molar ratio of 0.5 mol % to 10 mol % to all monomer units in the polymer. The polymer material can be used for manufacturing a composite film as a mask pattern for processing a target film on a substrate. The composite film can be formed by a process including, forming an organic film on the target film with the polymer material, patterning the organic film, and forming the composite film by impregnating a metal compound into the patterned organic film.Type: ApplicationFiled: September 6, 2019Publication date: September 17, 2020Applicant: TOSHIBA MEMORY CORPORATIONInventors: Koji ASAKAWA, Norikatsu SASAO, Shinobu SUGIMURA
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Publication number: 20200291157Abstract: An object of the present invention is to provide a curable composition having sufficient polymerization properties even under acidic conditions. The curable composition of the present invention includes (a) a polymerizable monomer having an acidic group, (b) a transition metal compound, (c) at least one compound selected from benzoxazole compounds and benzothiazole compounds, and (d) a reducing agent.Type: ApplicationFiled: October 25, 2018Publication date: September 17, 2020Applicant: MITSUI CHEMICALS, INC.Inventors: Takenori MITAMURA, Yoko KOSUGI
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Publication number: 20200291158Abstract: The invention relates to a novel synthesis process in order to produce meltable PAN copolymers with increased thermal stability. The PAN copolymers produced using the method according to the invention surprisingly exhibit improved thermal and mechanical properties compared to PAN copolymers produced using methods known from the prior art. The invention additionally relates to corresponding PAN copolymers and to molded bodies produced therefrom or to a method for producing such molded bodies, in particular melt-spun mono- or mufti-filaments.Type: ApplicationFiled: October 27, 2016Publication date: September 17, 2020Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V.Inventors: Mats Timothy KNOOP, Antje LIESKE, Mathias HAHN
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Publication number: 20200291159Abstract: Described herein are compositions suitable for use as binder components for inclusion in printing inks and coatings, such as those used in the gravure and flexographic printing process and which are printed on substrates such as polyolefin (e.g., polyethylene, polypropylene) and poly(ethylene terephthalate) (PET). The compositions are non-aqueous dispersions in which an one or more ethylenically unsaturated acrylates or (meth)acrylates is polymerized with a polyurethane, polyurethane-urea or polyurea in a non-aqueous polymerization medium, such as esters, ketones, and mixtures thereof, forming polymeric hybrid resins in the polymerization medium, which are solvent-dispersible hybrid resins of polyurethane-polyacrylate, polyurethane-urea-polyacrylate, and polyurea-polyacrylate. Films of hybrid resins are also disclosed.Type: ApplicationFiled: April 4, 2017Publication date: September 17, 2020Applicant: SUN CHEMICAL CORPORATIONInventors: David KLEIN, Michael J. JUREK, Juanita PARRIS
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Publication number: 20200291160Abstract: The present invention provides a silicone hydrogel composition. The silicone hydrogel composition includes a water-soluble silicone macromere, a hydrophilic monomer, a crosslinker, an initiator and an organic solvent. The water-soluble silicone macromere, the hydrophilic monomer, the crosslinker and the initiator is respectively in the amount of 50-80 wt %, 19-50 wt %, 0.1-1.5 wt % and 0.1-1 wt % based on the total weight of the silicone hydrogel composition.Type: ApplicationFiled: June 1, 2020Publication date: September 17, 2020Inventors: Yu-Chin LAI, Ting-Chun KUAN, Hsiang-Ho KUNG, Min-Tzung YEH, Ching-Wen YANG, Tsung-Kao HSU
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Publication number: 20200291161Abstract: A composition for model materials (4a) is used for shaping an optically shaped article by an inkjet optical shaping method, comprises a monofunctional monomer (A) and an oligomer (B) as a photocurable component, further, comprises no polyfunctional monomer (C) as a photocurable component, or comprises a polyfunctional monomer (C) as a photocurable component at 3.0 parts by weight based on 100 parts by weight of a whole composition for model materials, the oligomer (B) has a hydroxyl group or an amino group, and a total molar fraction of the hydroxyl group and the amino group in a total amount of the photocurable components is less than 5.0%. The composition for model materials (4a) can afford an optically shaped article that has flexibility, and does not crack even when it is bent.Type: ApplicationFiled: February 28, 2017Publication date: September 17, 2020Applicants: Maxell Holdings, Ltd., MIMAKI ENGINEERING CO., LTD., MIMAKI ENGINEERING CO., LTD.Inventors: Katsuyuki KITO, Taeko IZUMO, Masakatsu OKAWA, Kenta HONGO
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Publication number: 20200291162Abstract: The present invention relates to a thermoplastic copolymer resin having excellent heat resistance and transparency and a process for producing the same. More specifically, the present invention relates to a thermoplastic copolymer resin which is obtained by copolymerizing an ester oligomer having a specific structure with a polycarbonate oligomer, exhibits remarkably excellent heat resistance, and has excellent physical property balance such as transparency, impact strength, fluidity, etc.; a method for producing the same; and a molded article comprising the same.Type: ApplicationFiled: January 19, 2017Publication date: September 17, 2020Applicant: SAMYANG CORPORATIONInventors: Kyung Moo SHIN, Jin Sik CHOI, Young Do KWON
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Publication number: 20200291163Abstract: The present disclosure relates to a composition that includes where R1 and R2 include at least one of a hydrogen, a hydroxyl group, and/or an alkyl group, R3 and R4 include at least one of hydrogen, a hydroxyl group, an alkyl group, and/or a ketone, and 1?n?2000.Type: ApplicationFiled: March 16, 2020Publication date: September 17, 2020Inventors: Andrew Nolan WILSON, Michael Brandon GRIFFIN, Mark R. NIMLOS, Joshua A. SCHAIDLE
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Publication number: 20200291164Abstract: In one aspect, the invention provides a healable, recyclable and malleable e-skin. In certain embodiments, the e-skin comprises sensors that can detect at least one applied stimulus. In other embodiments, the e-skin comprises a dynamic covalent thermo set doped with a nano-particle composition, thereby rendering the doped thermoset conductive. The e-skin of the invention has potential applicability to the fields of robotics, prosthetics, health monitoring, biomedical devices and consumer products.Type: ApplicationFiled: November 20, 2018Publication date: September 17, 2020Inventors: Jianliang Xiao, Wei Zhang, Zhanan Zou, Chengpu Zhu
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Publication number: 20200291165Abstract: A method for preparing a thermoplastic polyoxazolidone, the method including catalytically reacting one or more aromatic diisocyanates and one or more diepoxides, wherein the one or more diepoxides comprise one or more 2-phenylpropane-1,3-diol diglycidyl ether derivatives. The one or more diepoxides further contain one or more diglycidyl ethers of aromatic diols.Type: ApplicationFiled: September 20, 2018Publication date: September 17, 2020Applicant: BASF SEInventors: Irene GORMAN, Veit STEGMANN, Hans-Josef THOMAS
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Publication number: 20200291166Abstract: A curable resin composition comprising: (1) a urethane (meth)acrylate; (2) a reactive diluent selected from the group consisting of i) a hydroxyl alkyl (meth)acrylate monomer where the acrylate group, which is attached to the carbonyl group, is attached to a hydrogen or a methyl group and the carbonyl group is attached to the hydroxyl group thru an R2 alkylene group containing 2 to 18 carbon atoms per molecule.Type: ApplicationFiled: March 1, 2017Publication date: September 17, 2020Inventors: Huifeng Qian, Muhammad A Shafi, Luigi Pellacani, Harshad M. Shah, Dwight Latham, Qiuyun Xu, William L. Heaner, Emanuele Maiocchi
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Publication number: 20200291167Abstract: A graphene-modified elastomer material and its preparation method. The elastomer material comprises a first component and a second component; the first component comprises isocyanate prepolymer obtained through reaction of polyol and isocyanate, and the isocyanate prepolymer has a —NCO content of 22-30%; the second component comprises the following components in parts by weight: 60-90 parts of polyetheramine, 1-10 parts of liquid amine chain extender, 1-5 parts of polytetrahydrofuran ether polyol, and 1-5 parts of graphenes. Through adjusting the —NCO content of the isocyanate prepolymer, increasing the hard segment content, and combining with the components in the second component, the invention ensures the elasticity of the polymer while improving its mechanical properties such as hardness and bending strength.Type: ApplicationFiled: January 21, 2020Publication date: September 17, 2020Applicant: Zhejiang Yuanrong Technology Co., LtdInventors: Songmao YU, Lvming XIAO, Yangang YU, Wanqin ZHANG, Qiwei ZHENG