Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Abstract: Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Abstract: Disclosed herein are methods for simulating the results of a visual field (VF) test using an optical coherence tomography (OCT) system. The disclosed methods may utilize structural information extracted from OCT image datasets, such as thickness measurements, or may utilize functional information, such as blood perfusion measurements, extracted from OCT angiography (OCTA) image datasets.

Abstract: The present invention relates to a method for supporting reading of a fundus image of a subject, and a computing device using the same. Specifically, the computing device according to the present invention acquires the fundus image of the subject, extracts attribute information from the fundus image on the basis of a machine learning model for extracting the attribute information of the fundus image, and provides the extracted attribute information to an external entity. In addition, when evaluation information on the extracted attribute information or modification information on the attribute information is acquired, the computing device according to the present invention can also update the machine learning model on the basis of the acquired evaluation information or modification information.

Abstract: An ophthalmologic processing apparatus according to embodiments acquires data of a fundus of a subject's eye optically. The ophthalmologic apparatus includes a fixation system, an image acquisition unit, a specifying unit, and a determination unit. The fixation system is configured to project fixation light onto an eye of a subject. The image acquisition unit is configured to acquire an image of the fundus of the subject's eye in a state where the fixation light is projected by the fixation system. The specifying unit is configured to analyze the image acquired by the image acquisition unit to specify an image region corresponding to a predetermined site of the fundus. The determination unit is configured to determine whether or not the image region specified by the specifying unit is included within a predetermined range in the image acquired by the image acquisition unit.

Abstract: A fundus imaging apparatus includes an imaging optical system that irradiates a fundus of a subject eye with light through an objective lens system, and enables to capture a fundus image of the subject eye based on return light from the subject eye, and a diopter correction unit that includes an optical element disposed on an optical path of the imaging optical system and a drive unit driving the optical element, and performs a diopter correction with a diopter value corresponding to a drive amount of the optical element. A drive range of the optical element in the diopter correction unit is set to avoid a specific range being a range in which an artifact caused by reflection light in the objective lens system is maximized.

Abstract: To make it possible to improve user convenience, provided is a control device including: a control unit configured to control a position and an attitude of a microscope unit by driving an arm unit that supports the microscope unit on the basis of a captured image of an operating site photographed by the microscope unit during an operation so that a position and attitude condition set before the operation is satisfied. The position and attitude condition is a condition that prescribes a position and an attitude of the microscope unit with respect to the operating site to obtain a desired captured image corresponding to the position and attitude condition.

Abstract: The present invention provides an ophthalmic device capable of minimizing the generation of flare at a lower cost and in a shorter time than in the prior arts when photographing in a state where an optical axis of an examination optical system is deviated from a reference position of a subject eye.

Abstract: Methods and apparatus, including computer program products, are provided for remote monitoring. In some example implementations, there is provided a method. The method may include receiving, at a remote monitor, a notification message representative of an event detected, by a server, from analyte sensor data obtained from a receiver monitoring an analyte state of a host; presenting, at the remote monitor, the notification message to activate the remote monitor, wherein the remote monitor is configured by the server to receive the notification message to augment the receiver monitoring of the analyte state of the host; accessing, by the remote monitor, the server, in response to the presenting of the notification message; and receiving, in response to the accessing, information including at least the analyte sensor data. Related systems, methods, and articles of manufacture are also disclosed.

Abstract: Methods and systems are provided to monitor bio-signals associated with one or more physiological structures of a subject, process the bio-signals to determine neural information, determine a current state of the subject based on the neural information, determine feedback to be provided to the subject based on the current state and a desired state, and/or to provide the feedback to the subject in order to modify the subject's current state to the desired state. The neural information may include validated neural indices relating to dynamic regulation of the monitored physiological structures via identifiable neural pathways and/or neural metrics quantified from such neural indices.

Abstract: Systems and methods for monitoring of biometric and contextual variables to assist in screening for, quantification of, and prediction of smoking behavior, and for assisting in smoking cessation are described.

Abstract: An automated system and method is provided for biotype extraction and biomarker discovery from task-based fMRI imaging data. The system and method may include automatically mapping a localizome, such as a task-condition/contrast/population-specific brain functional localizome, based on fMRI data and automatically selecting and sorting brain regions or brain nodes to produce a subset of functional brain regions or brain nodes. A report may then be generated indicating that the subject has a particular brain circuit pattern of activity and connectivity associated with one or more symptoms of the given mental disorder, treatments, or associated with normal brain functions, based upon the extracted biosignatures by searching for the optimal multivariate classifier with least dimensionality in the brain functional localizome.

Abstract: An intra-oral scanning device includes a light source and an optical system, and communicates with a display system. The device provides for more efficient transmission and capture of images. It integrates OCT scanning with RGB-based scanning. In operation, the device is used for recording topological characteristics of teeth, dental impressions, or stone models by digital methods and for use in CAD/CAM of dental restorative prosthetic devices. To that end, the RGB-based scan obtains surface data (e.g., a margin), while the OCT scan penetrates the surface. The two scanners operate from within the same physical housing and preferably at the same time such that only one scanning pass (to obtain all necessary data) is required. The 3D data obtained from the OCT scan is registered with the 3D data obtained from the RGB-based scan by virtue of being captured using a common return path.

Abstract: A measurement system comprises a pulsed laser diode array that includes one or more Bragg reflectors, and wherein the light generated by the array penetrates tissue comprising skin. At least some of the wavelengths of light are in the near infrared. The detection system is synchronized to the laser diode array and comprises an infrared camera and a first receiver comprising a plurality of detectors. The first receiver comprises one or more detector arrays and performs a time-of-flight measurement. The measurement system generates an image, the detection system non-invasively measures blood in blood vessels within or below a dermis layer within the skin based at least in part on near-infrared diffuse reflection from the skin, and the detection system measures absorption of hemoglobin between 700 and 1300 nanometers wavelength range. A processor compares the absorption of hemoglobin between different tissue spatial locations, and the measurement system processes the time-of-flight measurement.

Abstract: Generally described, the present disclosure relates to measuring core body temperature through respiratory mechanisms. The disclosed techniques can use surface temperature, exhaled air, perfusion information, blood oxygen saturation, respiration rate, circadian rhythms, and the like to obtain an accurate reading of the body's core temperature. Example devices are disclosed for obtaining core temperature from exhaled air and useful mechanisms for presenting this information to a user are also disclosed, including user interfaces and alarm mechanisms. Stereo thermometry methods may also be used to estimate core body temperature. This information can be used to track conditions of a subject, including fever status and comfortability, to ensure full consideration of a subject's well-being.

Abstract: The purpose of the present invention is to provide a sphygmomanometer that has a high level of measurement accuracy and places a low burden upon a subject whose systolic pressure is being measured. To this end, the sphygmomanometer according to the present invention is characterized by comprising: a cuff pressure and pulse wave detecting unit that detects cuff pressure and pulse waves; and a blood pressure calculating unit that divides pulse waves detected by the cuff pressure and pulse wave detecting unit into a plurality of sections within a specific period, and calculates an estimated value for systolic pressure on the basis of fluctuations in the symmetry of the pulse wave waveform in the plurality of sections, said fluctuations occurring along with variations in the cuff pressure detected by the cuff pressure and pulse wave detecting unit.

Abstract: Embodiments of the present invention provide reliable, convenient, and cost-effective methods and apparatuses to determine the hemodynamic status of the patent. The methods and apparatuses provide for the noninvasive determine of hemodynamic status by using systematic perturbations of venous return or trend observation over time. Embodiments do not require invasive pressure monitoring or the use of ventilator but instead can be an entirely noninvasive system.

Abstract: A biometric information measurement system includes a first measurement apparatus, a second measurement apparatus, and a control apparatus. The first measurement apparatus measures first biometric information of a subject. The second measurement apparatus measures second biometric information which is biometric information of the subject and which is different from the first biometric information. The control apparatus changes a condition of measurement performed by the second measurement apparatus on the basis of the first biometric information.

Abstract: Particular embodiments described herein provide for a wearable electronic device, such as a bracelet, coupled to a plurality of electronic components (which may include any type of components, elements, circuitry, etc.). One particular implementation of a wearable electronic device may include a plurality of sensors configured to measure at least one health parameter of a first user associated with the wearable electronic device, and a control module in communication with the plurality of sensors. The control module includes a processor configured to receive a plurality of health parameter measurements from at least a subset of the plurality of sensors, and determine a general health state of the first user based upon the received health parameter measurements.

Abstract: A blood flow rate measurement system measures fluid flow rate in a blood vessel having a catheter-based heart pump inserted therein, without relying on measurements of electric current drawn by a motor that drives the heart pump. A turbine is disposed at or near a distal end of the heart pump catheter. Blood or other fluid flowing through the blood vessel urges blades of the turbine to rotate. The turbine is mechanically coupled to a signal generator, which generates a signal indicative of a rotational speed of the turbine, which is dependent, at least in part, on speed of the fluid flowing through the blood vessel. A tachometer, external to the body of the patient, calculates the blood flow rate from the rotational speed of the turbine. In some cases, the blades are collapsible, to reduce diameter of the turbine, thereby facilitating insertion of the system into the blood vessel.

Abstract: A method for monitoring a cardiovascular pressure in a patient includes measuring, by pressure sensing circuitry of an implantable pressure sensing device, the cardiovascular pressure of the patient. The method further includes transmitting, via wireless communication circuitry of the implantable pressure sensing device, the measured cardiovascular pressure to another device. The method further includes determining, by processing circuitry of the other device, whether a posture of the patient at a time of the measured cardiovascular pressure was a target posture for cardiovascular pressure measurements. The method further includes determining, by the processing circuitry of the other device, whether to store or discard the transmitted cardiovascular pressure based on determining whether the posture was the target posture.

Abstract: An approach for determining an estimated pressure curve for the ventricle of the heart, the method comprising: using data from a motion sensor that has been implanted at the heart to determine the timing of heart cycle events; scaling a reference pressure-time curve including timing of reference heart cycle events in order to fit the reference pressure-time curve to the motion sensor data, the scaling comprising scaling the reference curve along the time axis to fit it to the measured timing of the heart cycle events; and thereby obtaining an estimated pressure-time curve in the form of the scaled reference pressure-time curve.

Abstract: A health & fitness tracking device may include a display that provides fitness information to a wearer of the health & fitness tracking device, at least one physiological sensor that obtains physiological data by monitoring at least one physiological condition of the wearer, at least one environmental sensor that obtains environmental data by monitoring at least one environmental condition, a data storage device that stores the physiological data, the environmental data, and medical history data relating to the wearer, a memory storing a computer program, and a processor that executes the computer program. The computer program may adjust a sensor configuration of the at least one physiological sensor based on the medical history data.

Abstract: A spectrally encoded flow cytometry (SEFC) technique for imaging blood in the microcirculation. Since the dependency of one of the axes of the image on time prevents effective quantification of essential clinical parameters, the optical path in an SEFC system is split into two parallel imaging lines, followed by data analysis for recovering the flow speed from the multiplexed data. The data analysis may be auto-correlation of a pair of images obtained from a sequence of images of the imaged blood vessel.

Abstract: A diagnostic system includes one or more blood flow sensors adapted to contact but not penetrate the skin of the pedal arch and aligned with blood vessels of the pedal arch. Readings from the blood flow sensors are transformed into blood flow acceleration times, and the blood flow acceleration times are used to identify a blood flow pathology.

Abstract: Provided here are methods of detecting compromised cerebrovascular reactivity in a subject and treating such subject. The method includes acquiring transcranial Doppler signals and cardiac measurements from the subject following a breath-hold maneuver and recording a test set of CBFV measurements. A breath-hold acceleration index is calculated based on a linear regression correlation of temporal variations of the mean velocity across all cardiac cycles during the breath-hold maneuver. The presence of compromised cerebrovascular reactivity in the subject is detected in response to variations in the breath-hold acceleration index of the subject as compared to a healthy individual performing breath-hold maneuver under similar conditions. If the subject has compromised cerebrovascular reactivity, a therapeutically effective compound is administered to the subject along with provision of behavioral modification regimen.

Abstract: An apparatus for measuring bio-information may include: a pulse wave sensor comprising at least one pair of light emitters which are disposed apart from each other and a light receiver disposed between the at least one pair of light emitters, and configured to measure a plurality of pulse wave signals from an object by using the light receiver and the at least one pair of light emitters; a force sensor configured to measure a contact force that is applied to the pulse wave sensor by the object; and a processor configured to generate an integrated pulse wave signal by integrating the plurality of pulse wave signals based on the contact force and an area of a contact surface of the pulse wave sensor, and estimate bio-information of the object based on the integrated pulse wave signal.

Abstract: A biological information measuring apparatus includes a distortion calculating unit that calculates, based on video pulse wave information representing a video pulse wave expressing a temporal change in a brightness value included in a video signal of a predetermined part of a subject, a waveform distortion obtained from a heartbeat basic component containing a frequency component of a heartbeat frequency band corresponding to a heart rate of the subject and a heartbeat high-frequency component related to a waveform of a pulse wave and containing a frequency component of a frequency band higher than the heartbeat frequency band, the heartbeat basic component and the heartbeat high-frequency component being included in the video pulse wave; and a measuring unit that measures a fluctuation in a blood pressure of the subject based on the waveform distortion calculated by the distortion calculating unit.

Abstract: Systems and methods for detecting cardiac arrhythmia are discussed. An exemplary medical-device system includes an arrhythmia detector circuit that receives physiologic information, including respiration and heart beat information a patient, and determines whether a respiratory sinus arrhythmia (RSA) is present or absent using the respiration and the heart beat information. An indication of the presence or absence of RSA may be stored in a memory. The arrhythmia detector circuit can detect an AT episode using the indication of RSA.

Abstract: A method of modelling and extracting information from a photoplethysmography, PPG, signal comprises decomposing and modelling (102) the PPG signal as a long-term periodic component and a short-term periodic component. The method further comprises summarizing (104) the information contained in the PPG signal, based on a distribution of fitted parameters of the modelled long-term and short-term periodic components.

Abstract: Provided are adaptive wearable devices that measure physiological conditions, methods of operating the device, and computer programs for use with the device. The adaptive wearable device provides improved reliability in data due to the adaptive structure and can be made waterproof with the incorporation of a polymer material. In the context of a wearable device, an apparatus is provided that includes a support structure configured to at least partially enclose the torso or an appendage of a user, a spring module disposed on the support structure, a first section of flexible circuitry disposed on the spring module and a first sensor disposed on the spring module and configured to monitor the user.

Abstract: A system for providing a report on vascular health of a user is disclosed. The system includes a toilet with a bowl adapted to receive excreta from the user and a processor. The toilet includes a seat with weight and PPG sensors. BCG data is derived from the weight sensor data. PPG data is derived from the PPG sensor. The processor performs a comparison of the data from the weight sensor and the data from the PPG sensor and preexisting data in a database. The processor then generates a report on the user's vascular health based on the comparison.

Abstract: A wearable device has a housing containing electronics and a band that retains the wearable device on a user's arm. Each end of the housing has a receptacle with a ridge around the opening of the receptacle. A band comprises a strip of flexible material. A pair of protrusions with enlarged ends made from an elastomeric material extend from an inner surface of the band. A portion of the inner surface of the band between the protrusions is in contact with at least a portion of an upper surface of the housing. The band is joined to the housing by aligning each protrusion with a corresponding receptacle and applying pressure. As a result of the applied pressure part of the protrusion temporarily deforms, enters the receptacle, and resumes substantially the previous shape thus holding the protrusion within the receptacle and the band to the housing.

Abstract: ElectroCorticoGraphy (ECoG) sensors and uses are disclosed. These ECoG arrays, systems, and processes may be operable or configured to: i) simultaneously record neural signals while providing stimulation on specific portions of the cortex using a user-guided stimulator; ii) acquire neural signals over a large cortex area; iii) provide individual or group stimulation while concurrently receiving neural feedback; and/or iv) acquire neural signals at a setting remote from the neural source using wireless or other communication techniques.

Abstract: A method of tracking a position of a catheter within a patient includes securing a navigational reference at a reference location within the patient, defining the reference location as the origin of a coordinate system, determining a location of an electrode moving within the patient relative to that coordinate system, monitoring for a dislodgement of the navigational reference from the initial reference location, for example by measuring the navigational reference relative to a far field reference outside the patient's body, and generating a signal indicating that the navigational reference has dislodged from the reference location. Upon dislodgement, a user may be provided with guidance to help reposition and secure the navigational reference to the initial reference location, or the navigational reference may be automatically repositioned and secured to the initial reference location. Alternatively, a reference adjustment may be calculated to compensate for the changed reference point/origin.

Abstract: A signal processing apparatus includes a memory, and a processor coupled to the memory and configured to perform a process including obtaining measurement data including a signal of interest and an interference signal generated in proximity to a signal source of the signal of interest, estimating a signal source in an extraction target area including the signal source of the signal of interest and a signal source of the interference signal based on the measurement data, selecting the signal source of the interference signal based on a result of the estimating a signal source and extracting interference signal data generated from the selected signal source of the interference signal, and extracting the signal of interest by removing a common part between the measurement data and the interference signal data.

Abstract: In one aspect, a computer-implemented method corrects a multi-sphere head model used in dipole localization for a set of magnetic field sensors (MEG sensors) by replacing ghost spheres with replacement spheres that are not ghost spheres. One type of ghost sphere completely encloses the brain volume but is so large that a center of the sphere is outside the brain volume. Another type of ghost sphere lies entirely outside the brain volume. Various approaches for correcting ghost spheres are disclosed.

Abstract: An information processing device, an information processing method, a recording medium storing a program, and a biomedical-signal measuring system. The information processing device includes circuitry to obtain specific information of a first intensity distribution of a biomedical signal from a source, the specific information being displayed on a display, and extract, based on the specific information, a specified area of the first intensity distribution to obtain second intensity distribution of the biomedical signal to be superimposed on an image indicative of the source. The information processing method includes obtaining specific information of a first intensity distribution of a biomedical signal from a prescribed source, the specific information being displayed on a display, and extracting, based on the specific information, a specified area of the first intensity distribution to obtain second intensity distribution of the biomedical signal to be superimposed on an image indicative of the source.

Abstract: In one aspect, a computer-implemented method corrects a multi-sphere head model used in dipole localization for a set of magnetic field sensors (MEG sensors) by replacing ghost spheres with replacement spheres that are not ghost spheres. One type of ghost sphere completely encloses the brain volume but is so large that a center of the sphere is outside the brain volume. Another type of ghost sphere lies entirely outside the brain volume. Various approaches for correcting ghost spheres are disclosed.

Abstract: A brain response measurement system includes a stimulation timing control unit calculating, based on a delay time from a brain response to first stimulation in a first brain area to a brain response to a second stimulation in the first brain area, and a delay time from a brain response to the second stimulation in the second brain area to a brain response to the first stimulation in the second brain area, start and end times of the first stimulation and start and end times of the second stimulation that cause the brain response to the first stimulation in the first brain area and the brain response to the second stimulation in the first brain area not to overlap and cause the brain response to the second stimulation in the second brain area and the brain response to the first stimulation in the second brain area not to overlap.

Abstract: Disclosed is a system for assessing and monitoring muscle performance with self-adjusting feedback in order to evaluate progress in physiotherapy received by patients who have suffered muscle damage, the method including: A) at least one apparatus for acquiring muscle or biopotential signals; signal conditioning; processing, sending, receiving information; and self-adjusting feedback; B) at least one external computer and/or monitor or graphic interface for viewing external information; C) wherein the at least one apparatus for acquiring muscle or biopotential signals; signal conditioning; processing, sending, receiving information; and self-adjusting feedback and the at least one external computer and/or monitor or graphic interface for viewing external information are configured to carry out a method for measuring, extracting and processing parameters for assessing and monitoring muscle performance with self-adjusting feedback in order to evaluate progress in physiotherapy received by patients who have suff

Abstract: A method for classifying types of heartbeats includes obtaining a dataset including multiple heartbeat waveform data, generating, from the dataset, input data regarding a heartbeat waveform for training and generating a learning model to which the generated input data is input and from which a heartbeat type of the heartbeat waveform for training is output, training the learning model by determining a loss weight of each batch sampled from the dataset and determining a loss function based on the loss weight of each batch, and inputting a heartbeat waveform for test to the learning model and classifying a heartbeat type of the heartbeat waveform for test.

Abstract: Systems and methods for performing online spike recovery from multi-channel electrophysiological recordings in accordance with various embodiments of the invention are described. One embodiment of a method of performing online spike recovery from multi-channel electrophysiological recordings includes: determining a set of waveform templates; continuously obtaining multi-channel electrophysiological recordings using a multi-channel electrode; and automatically performing online spike recovery from the multi-channel electrophysiological recordings using a processing system that performs a method for sparse signal recovery that continuously adjusts a processing buffer size based upon newly obtained multi-channel electrophysiological recordings.

Abstract: The present disclosure is directed to systems and methods for endovascular electroencephalography (EEG) and electrocorticography (ECoG) systems. In some embodiments, the disclosed systems include electrode arrays that are configured to record and/or stimulate brain tissue via placement within blood vessels of the brain. Venous and arterial EEG and ECoG electrodes, ambulatory EEG and ECoG systems, and transcutaneous access and signal control systems for general and ambulatory endovascular electroencephalography (EEG) and electrocorticography (ECoG), as well as endovascular neural stimulating electrodes are discussed.

Abstract: According to various aspects, a sensor system is provided comprising a first substrate configured to be coupled to a user, an electric field detector to detect a user electric field and comprising a second substrate, a proof mass positioned above the second substrate, one or more electrodes coupled to the second substrate, and a control circuit coupled to the one or more electrodes, the control circuit being configured to determine a change in capacitance between the proof mass and each electrode responsive to torsional movement of the proof mass responsive to the electric field, and a controller coupled to the first substrate and being configured to receive, from the detector, information indicative of each change in capacitance between the proof mass and each electrode, and determine, based on the information, characteristics of the electric field in at least two dimensions.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Abstract: The invention disclosed in this application is an electromyography needle that contains smaller internal electrodes. When inserted into a patient, the smaller electrodes are deployed from the main carrier needle into the surrounding muscle or tissue. The deployment of the multiple electrodes from a single needle increases the surface area for the electromyography test and reduces patient discomfort.

Abstract: A user-specific model of muscular activity can be used to control an external device based on muscular activity within a limb of a user. The user-specific model of muscular activity can include single movements and corresponding one or more primary muscle patterns. New single movements can be added to the user-specific model of muscular activity can be by a system that includes a processor by receiving user-specific EMG signals (including one or more EMG patterns that indicate a single movement); decomposing the user-specific EMG signals into the one or more EMG patterns in EMG feature space that indicate the single movement; and updating the user-specific model of muscular activity to include the single movement and corresponding one or more primary muscle patterns based on the one or more EMG patterns in EMG feature space.

Abstract: The present invention relates to a bio-electrode having improved conductivity, flexibility and bio-compatibility, and a method of manufacturing the same. Specifically, the present invention relates to a conductive polymer bio-electrode including nano-porous permeable membrane, based on a bio-compatible polymer material having a plurality of pores and an improved surface area based on a PDMS device having a low mechanical strength and an excellent bio-compatibility, bio-signal transmission patterning, and a gold coating layer and has an excellent bio-compatibility and low rejection response while having a conductivity similar to that of a bio-electrode configured with a metal material of the related art. Therefore, the conductive polymer bio-electrode of the present invention is expected to be able to replace a bio-electrode configured with a metal material by which the bio-signal transmission efficiency is degraded due to a high bio-incompatibility.