Abstract: Apparatuses, systems and methods for providing improved intraocular lenses (IOLs), include features for reducing side effects, such as halos, glare and best focus shifts, in multifocal refractive lenses and extended depth of focus lenses. Exemplary ophthalmic lenses can include a continuous, power progressive aspheric surface based on two or more merged optical zones, the aspheric surface being defined by a single aspheric equation. Continuous power progressive intraocular lenses can mitigate optical side effects that typically result from abrupt optical steps. Aspheric power progressive and aspheric extended depth of focus lenses can be combined with diffractive lens profiles to further enhance visual performance while minimizing dysphotopsia effects.

Abstract: A prosthetic valve including an inner frame, an outer frame, and a connection assembly interconnecting the frames. The inner frame defines an interior volume for receiving a valve structure within the interior volume. The outer frame surrounds the inner frame. The inner and outer frames are each configured to be transitionable between compressed and expanded conditions. The prosthetic heart valve provides a initial deployed state in which the inner and outer frames are in the expanded condition, and a radial shape of the outer frame is adjustable via the connection assembly to a final deployed state. A shape of the outer frame can be adjusted upon implant to enable radial anchoring at the native annulus, while addressing possible non-uniformities of the native annulus and possible anatomical concerns such as LVOT obstruction.

Abstract: Methods of implanting docking devices for prosthetic valves at a native heart valve include positioning a distal end of a delivery catheter into a first chamber of a heart, advancing a tubular body of a docking device from within the delivery catheter so that the distal end of the tubular body is advanced between native valve leaflets and positioned in a second chamber of the heart. The methods further include inserting a coil into a lumen of the docking device so that the tubular body adopts a configuration, releasing a proximal end of the docking device in the first chamber, inserting a replacement valve in an inner space of the docking device, and radially expanding the replacement valve until there is a retention force between the replacement valve and the docking device to hold the replacement valve in a stable position in the native valve.

Abstract: A stent device having a skirt (2, 107) for peripheral leakage prevention and a processing method thereof, a skirt (2, 107) folding method, and a heart valve. The stent device comprises a stent (1, 105) and a flexible skirt (2, 107), the skirt (2, 107) having an expanded state, in which the skirt is axially extended and surrounds the stent (1, 105) before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent (1, 105) is released, collapses and folds axially along the released stent (1, 105) so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent (1, 105) to fit to the inner wall of a vessel more snugly, such that the stent (1, 105) does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus.

Abstract: Embodiments of the present disclosure are directed to stents, valved-stents, (e.g., single-stent-valves and double stent/valved-stent systems) and associated methods and systems for their delivery via minimally-invasive surgery. The stent component comprises a first stent section (102) a second stent section (104) a third stent section (106) and a fourth stent section (108).

Abstract: The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing members configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes a collapsible and expandable annular frame, a collapsible and expandable valve member mounted within the annular frame, and a collapsible and expandable sealing skirt mounted on the annular frame, wherein the sealing skirt is a pile fabric and can contact tissue surrounding the prosthetic valve when the prosthetic valve is implanted within a native valve annulus.

Abstract: Embodiments of a prosthetic heart valve comprise an annular main body, an atrial cap extending radially outwardly from the atrial end of the main body, and a plurality of ventricular anchors extending outwardly from the ventricular end of the main body. Each ventricular anchor can have a proximal end portion connected to the ventricular end, an intermediate portion extending away from the atrial end and then back toward the atrial so as to define a first bend, and a free distal end portion that extends from the intermediate portion. The distal end portion can comprise a first section, a second section, and a second bend between the first and second sections, the first section extending from the intermediate portion in a direction toward the atrial end and radially away from the main body.

Abstract: Transcatheter delivery systems, delivery catheters and associated methods for percutaneous delivery of prosthetic mitral valves using a retrograde approach are disclosed herein. A heart valve delivery system configured in accordance herewith includes a delivery catheter having an elongated tubular component and an articulation assembly at a distal end thereof. The articulation assembly includes an arm portion coupled to the tubular component by an elbow or hinge portion. In a closed, delivery state, the elbow portion positions the arm portion generally parallel to the tubular component for delivery of the delivery catheter through the vasculature. In an open, deployed state, the elbow portion positions the arm portion in a non-axial direction with respect to a longitudinal axis of the tubular component for orienting and positioning a prosthetic valve device carried by the arm portion, e.g., within the native mitral valve region.

Abstract: A prosthetic valve may be used to repair a diseased or otherwise damaged heart valve such as the mitral valve. The prosthetic valve may include atraumatic anchor tabs which may be radiopaque or echogenic. A cinching mechanism may also be coupled to the prosthetic valve to control radial expansion of the prosthetic valve. The cinching mechanism may include a wire lasso or a belt. The prosthetic valve may include an expandable frame which has a reduced number of strut connection nodes to allow a lower profile collapsed configuration and tighter crimping. The commissure posts of the prosthetic valve may extend beyond an edge of the ventricular skirt portion of the device.

Abstract: A delivery device includes an inner shaft, an outer sheath, a nosecone, and a tether component. The outer sheath is slidably disposed over the inner shaft. The nosecone is removably coupled to the inner shaft. The nosecone includes a delivery configuration for delivery to a treatment site, a radially compressed configuration in which a portion of the nosecone is configured to traverse through a heart wall, and a radially expanded configuration in which an outer surface of the nosecone contacts an outer surface of the heart wall. The tether component includes a first end coupled to the nosecone. The nosecone is configured to plug a piercing in the heart wall when in the radially expanded configuration.

Abstract: A heart valve anchor apparatus may include a body having a proximal portion and a distal portion. The body may include a first radially expandable portion at the proximal portion of the body, a second radially expandable portion at the distal portion of the body, and a root portion extending from the first radially expandable portion to the second radially expandable portion, the root portion having an outer extent. The first radially expandable portion may be configured to self-expand to an outer extent greater than the outer extent of the root portion when radially unconstrained. The second radially expandable portion may be configured to self-expand to an outer extent greater than the outer extent of the root portion when radially unconstrained. In an unstressed configuration, the body may define a longitudinal centerline that extends away from a plane tangent to the root portion.

Abstract: The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treats mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.

Abstract: This disclosure relates generally to prosthetic valves and methods and systems for deploying, positioning, and recapturing the same. A prosthetic valve includes one or more support structures. At least one of the one or more support structures defines an elongate central passageway of the prosthetic valve. The prosthetic valve can also include a plurality of leaflet elements attached to at least one of the one or more support structures and disposed within the elongate central passageway for control of fluid flow through the elongate central passageway. At least one of the one or more support structures is configured to biodynamically fix the prosthetic valve within a native valve such as, for example, a native tricuspid valve of a heart.

Abstract: A method of providing a person assigned female sex at birth with a neopenis includes forming a neophallus by inverting a wall of the vagina outside of a pelvis; and implanting a penile prosthetic into the neophallus.

Abstract: A medical implant structure is provided comprising a substrate 10 with at least a first surface and a second surface that surfaces differ from one another with regard to at least one property in relation to biological material.

Abstract: A surgical fastener comprising a generally flat, circular body and a generally cylindrical post fixedly coupled to a center of the body extending perpendicular to the body. Both of the body and the post include through holes configured for passage of a suture. A length of the post is selected to extend through both of a bone graft and at least a portion of bone for providing shear and/or anti-rotational support to the surgical fastener across a fracture line in the bone.

Abstract: A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.

Abstract: The invention relates to an endoprosthesis shaft system for elongate bones, comprising an anchoring part (10) and a shaft (1), which is formed from module elements that can be coupled by means of a plug-in connection (45), wherein a mutual rotation of the elements along the shaft (1) is adjustable and is blocked by means of an anti-rotation mechanism. In order to adjust the rotation, a rotation piece (5) is provided as a further module element, which has a self-contained rotation adjustment device (6) and a clamping device (7) as a mechanism for blocking the rotation. The rotation piece (5) comprises two end faces for the plug-in connection (45) and a sleeve (77). The invention provides, with the rotation piece, a particular module element for the shaft, which as a structural unit allows both an adjustment of the rotation and a blocking against undesired rotation in a self-contained unit.

Abstract: There is provided a tibial component (100) comprising a tibial tray (102) having a superior side and an inferior side, and a support member (104) connected to the inferior side of the tibial tray, the support member having a stem portion (120), the stem portion including one or more fins (130) and a first arm (134) angled relative to a second arm (136). In one form, the fins have a curvature that extends away from the stem portion. In another form, the first arm defines an opening sized to receive an anchor wherein the anchor is configured to penetrate a portion of bone and the opening in the first arm. Optionally, the stem portion includes a first portion (1022) having a first cross sectional area and a second portion (1024) having a second cross sectional area wherein the first cross sectional area is larger than the second cross sectional area. The fins and arms can include rail protrusions (1186).

Abstract: Bone joint implants are described herein. The bone joint implants may comprise a metallic proximal platform configured for translational motion on the trapezium bone; a distal stem configured for intramedullary engagement with an end of the first metacarpal bone; an articulating coupling between the proximal platform and distal stem; and a proximal non-metallic wear surface and a distal non-metallic wear surface.

Abstract: Inflatable orthopedic implants and related methods are disclosed herein, e.g., for deploying such implants within an intervertebral space for use in spinal fusion surgery, other intervertebral surgical procedures, or other surgical procedures. The inflatable intervertebral implant can include a hollow inflatable body that can be configured in a compact state for insertion into a target intervertebral space between a pair of adjacent vertebral bodies. Once the vertebral bodies are separated or distracted, e.g., using one or more inflatable distractors, the hollow body of the inflatable implant can be inflated with bone cement or other curable material. When the curable material hardens, the inflated implant can form a rigid intervertebral support structure (e.g., a fusion cage) capable of maintaining the vertebral distraction and thereby enabling removal of the distractors.

Abstract: An intersomatic prosthesis with lateral introduction with a prosthesis body symmetrical along a sagittal plane is provided. The intersomatic prosthesis includes a convex anterior lateral wall along an anterior radius of curvature and a convex posterior lateral wall along a posterior radius of curvature larger than the anterior radius of curvature, a right end wall and a left end wall, and a lower bearing wall and an upper bearing wall open onto an inner space. The lower bearing wall has a central lower portion provided with lower teeth having lower bearing tips defining a lower bearing surface which is planar, and the upper bearing wall has a central upper portion provided with upper teeth having upper bearing tips defining an upper bearing surface which is convex.

Abstract: A flexible chain implant for insertion into an interior volume of a vertebral body. The implant may be implanted in an insertion position for sliding through a cannula and is flexible for packing into the interior volume in an implanted configuration. The implant randomly separates in the implanted configuration. The implant includes a top member and a bottom member, wherein the top and bottom members are coupled to one another at a coupled portion. The top and bottom members preferably each include an inner surface such that the inner surfaces include a plurality of alternating projections and recesses so that the projections are received within the recesses in an insertion position. Alternatively, the implant may include a plurality of substantially non-flexible bodies and a plurality of substantially flexible links interconnecting the bodies. The non-flexible bodies include a plurality of facets and/or abutment surfaces.

Abstract: A bone graft delivery system includes a rasp having an elongate body extending between a proximal end and a distal end, a lumen extending through the elongate body and configured to receive bone graft material, a rasping surface removably couplable to the distal end of the elongate body and configured to decorticate bone material of a patient, and one or more openings configured to deliver bone graft material from the lumen.

Abstract: A method and system for determining the orientation of a surgical tool with respect to a bone of a patient discloses initializing a first active sensor and a second active sensor relative to each other with the first active sensor and second active sensor having a predetermined (relative) orientation. The first active sensor is configured to sense a change in its orientation, provide first information relating to the change and be attached to a bone in a relationship to a reference plane therefor, for use during an operation. The second active sensor is configured to sense a change in its orientation, provide second information relating to the change and be attached to a surgical tool. The relative orientation of the active sensors is useful to determine the relative orientation of the tool and the reference frame of the bone.

Abstract: Modular arm prosthesis, for amputations higher than the level of the forearm. With the feature of being modular, which gives us an advantage that reduces the repair time by replacing the module quickly. The Socket-stump module which can be adjusted to several stumps thanks to its pneumatic system for grip, decreases the level of customization of each prosthesis thus reducing the manufacturing time and cost of production of each prosthesis, as well as its easy control by means of myoelectric sensors.

Abstract: A sliding assembly may include a supporting frame having a proximal end and a distal end, a sliding frame partially inserted to the supporting frame, and a supporting member disposed between the supporting frame and the sliding frame to prevent the supporting frame from directly contacting the sliding frame, wherein the sliding frame is configured to move relative to the supporting frame.

Abstract: A system and method for a prosthetic assembly that includes a first prosthetic component, comprising a prosthetic hand base; a set of second prosthetic components, comprising a set of prosthetic fingers, and a set of actuating systems, wherein one actuating system connects a pair of distinct prosthetic components, enabling actuation of one prosthetic component with respect to the other. Each actuating system, from the set of actuating systems, includes a linkage and a sensored brushless motor; wherein the sensored brushless motor comprises a brushless motor, a field oriented control system, a rotary encoder, and a gearbox.

Abstract: A system consisting of at least one orthopaedic component, having at least one stored energy source and multiple electrical and/or electronic devices, and at least one operator control device and/or feedback device, which is assigned to the electrical and/or electronic devices and is coupled to them.

Abstract: A method for distributing a limited amount of electrical power from an energy source to a plurality of electrical loads includes sensing and/or encoding the available electrical power of the energy source, monitoring a power balance of the loads by sensing and/or encoding the drawn power in the individual loads, and reducing the drawn power in the loads if the available power is not sufficient for supplying all the loads with the required power.

Abstract: A prosthesis system includes a liner made of an electrically non-conducting liner material, which is intended to be pulled over an amputation stump, at least one electrode, which has at least one contact surface, and a prosthesis socket, which is intended to be arranged on the amputation stump. The at least one electrode is arranged on the inner face of the prosthesis socket, at least one area of the liner has a multiplicity of lead-throughs from the inner face to the outer face made of an electrically conducting material arranged in the liner material, and the at least one contact surface of the at least one electrode is intended to come into contact with at least one lead-through during use.

Abstract: A medical device is provided comprising an at least one surface deposited with at least a first conformal coating and a second conformal coating deposited on the first conformal coating, wherein the first conformal coating comprises the first chemical substance and the second conformal coating comprises the second chemical substance. In some instances, the first coating is deposited over the first chemical substance and the second coating is deposited over the second chemical substance.

Abstract: The techniques of this disclosure generally relate to a modular stent device that is deployed via supra aortic access through the brachiocephalic artery. The modular stent device is a base or anchor component to which additional modular stent devices can be attached to exclude diseased areas of the aorta while at the same time allowing perfusion of the left common carotid artery and the left subclavian artery.

Abstract: A system for deploying a prosthesis over a Carina between an ipsilateral lumen and a contralateral lumen includes a guidewire, a guidewire capture catheter, a self-expanding tubular prosthesis, and a delivery catheter. The guidewire is first placed in the ipsilateral lumen. The guidewire capture catheter is then advanced from the contralateral lumen to a position at or above the ipsilateral lumen. The guidewire is typically advanced through an occlusion, which may be a total occlusion, and captured by a capture element on the guidewire capture catheter. The guidewire capture catheter pulls the guidewire out through the contralateral side, and the guidewire is used to advance a delivery catheter from the ipsilateral side. The delivery catheter delivers a first segment of the tubular prosthesis in the ipsilateral lumen and a second segment of the prosthesis in the contralateral lumen.

Abstract: The techniques of this disclosure generally relate to a modular stent device that is deployed into the ascending aorta via femoral access. The modular stent device is a base or anchor component to which additional modular stent devices can be attached to exclude diseased areas of the aorta while at the same time allowing perfusion of the brachiocephalic artery, the left common carotid artery, and/or the left subclavian artery.

Abstract: Described herein are radially self-expanding stents. The disclosed stents can be used to widen arteries and/or veins of a patient to counteract or combat narrowing of the arteries and/or veins associated with certain congenital diseases, such as aortic coarctation. As an example, the disclosed stents are configured to be placed at or near a narrowed portion of the aorta where the stent produces a radial outward force on the aorta. The radial force produced by the stent widens the aorta and causes the stent to expand with the aorta. The disclosed stents can be crimped to relatively small sizes for placement in small patients (e.g., less than about 10 kg in size) and can be configured to expand to widen the aorta and to accommodate growth in the patient.

Abstract: The present disclosure is directed to a branched endoprosthesis comprising a graft component and at least one support component. In various embodiments, the branched endoprosthesis comprises a body portion and a plurality of leg portions, wherein the legs are in an aligned configuration for ease of cannulation. In various embodiments, at least one leg is in an open configuration for ease of cannulation. Cannulation methods are also described.

Abstract: Crimping device (1) for reducing the diameter of collapsible valves, said device (1) including at least two independent cylindrical crimping units (2, 3, 4) that are each adapted to crimp a different specific part of a valve, independently from the other crimping unit(s), each of said unit (2, 3, 4) comprising a diaphragm rotation crimping mechanism that includes crimping jaws, and wherein each unit (2, 3, 4) comprises an actuator for activating said mechanism, characterized by the fact that said actuator is a handling screw (51, 61, 71) that is tangentially fixed to the external surface of the cylindrical crimping unit (2, 3, 4).

Abstract: An orthopedic device comprises a hinge assembly including: a first hinge arm having a first longitudinal axis, and defining a first end portion having a first opening defining a first axis so the first hinge arm is pivotable about the axis; a second hinge arm having a second longitudinal axis, and defining a second end portion having a second opening defining a second axis and the second hinge arm is pivotable about the second axis. When the first and second longitudinal axes are coaxial, the second opening is arranged along a third longitudinal axis parallel to the first and second longitudinal axes and offset by a distance. The orthopedic device includes additional features including frame components and liner, contoured and formed geometrically with materials providing an improved fit.

Abstract: An inflatable brace. The inflatable brace including a flexible variably inflatable membrane elongated in a first direction and a second direction, the flexible variably inflatable membrane being fastenable around an object and inflatable to provide particular structural support to the object and an inflatable channel disposed between a first layer of the variably inflatable membrane and a second layer of the variably inflatable membrane, the inflatable channel comprising a predetermined arrangement of segregated inflatable sub-channels that are segregated by a plurality of dividers, the arrangement of segregated inflatable sub-channels, when inflated, providing the particular structural support to the object.

Abstract: A comfort harness for an orthotic brace being fully adjustable and having a crescent-shaped pad located about the front shoulder of a wearer for dispersing a load and for added comfort for the wearer. Multiple straps are provided for upper back, under arm, and cross-body support for the wearer. The comfort harness configured to connect with a variety of orthotics for an arm, a shoulder, and the like. In some cases, the comfort harness is capable of being donned and adjusted by the wearer when in a supine position.

Abstract: Disclosed is a complementary-material element (22) attachable to a base plate (24) of an ostomy appliance (20) and including a first entity (30) and a second entity (32). The entities comprise different material compositions. The material composition of the second entity comprises a neutralizer which is released from the complementary-material element in response to moisture, thereby neutralizing the damaging effects of stomal output.

Abstract: A monitor device for an ostomy system comprising an ostomy appliance with a base plate and a method of monitoring an ostomy appliance is disclosed.

Abstract: A system suitable for collecting and transporting urine away from the body of a person or animal may include an assembly having a fluid impermeable casing, a fluid permeable membrane, and a fluid permeable support. A reservoir is defined by the fluid permeable support. The fluid permeable membrane can define a cavity. The casing can define an opening such that the cavity is accessible via the opening. The assembly can also include an outlet in fluidic communication with the reservoir. The assembly can be arranged such that a user's penis can be disposed through the opening with the urethral opening disposed within the cavity and such that a fluid can flow into the body from the urethral opening of the user's penis, collect in the reservoir, and flow out of the outlet.

Abstract: The anti-snoring assembly includes an anti-snoring body, with the anti-snoring body, including a top side, a triangle side 1.0, a triangle side 2.0, and a bottom side. The top side 2.0 includes a left surface and a right surface, and the triangle side 1.0 includes a triangle side 1.0 surface. The triangle side 2.0 includes a triangle side 2.0 surface, where the bottom side 2.0 includes a bottom side surface. The anti-snoring system is structured and arranged to be placed beneath a pillow of a user to provide the user with a favorable downward head angle for reducing or preventing snoring during sleep. Embodiments include arrangements where the triangle side 1.0 is flat, and both the triangle side 2.0 and the bottom side are triangular. Additionally, the left surface and the right surface of the top side of the anti-snoring system may each resemble a flat plane.

Abstract: A collapsible pessary is provided, and can have a stem and at least one hingedly attached petal member that can rotate between a collapsed state with a smaller diameter and a deployed state with a larger diameter. In the deployed state, the at least one petal member can extend outward from the stem, and in the collapsed state, the at least one petal member can be rotated upwards so that the diameter of the pessary is smaller in the collapsed state than in the deployed state. The pessary can be in a collapsed state wherein its overall diameter is at a minimum, or a deployed state, wherein its overall diameter is at a maximum.

Abstract: A therapy pack system provides a reusable self-adhering therapy pack to skin. The therapy pack may be for example, an ice pack, heat pack or hot and cold pack. A sticky polymer gel is mounted onto a polymer casing of the therapy pack. The polymer gel is re-usable to attach the therapy pack to a user's skin at the site needing therapy. The polymer gel also buffers the skin from heat or freezer burn associated with applying a hot/cold pack to skin for an extended period. A chloride based compound may be added to the polymer gel to prevent the gel from freezing. In some embodiments, a non-woven fabric patch may support the polymer gel adhesive providing an additional layer of protection to the skin while simultaneously allowing the gel to self-adhere the therapy pack to the user.

Abstract: Relatively non-invasive devices and methods for heating or cooling a patient's body are disclosed. Devices and methods for treating ischemic conditions by inducing therapeutic hypothermia are disclosed. Devices and methods for inducing therapeutic hypothermia through esophageal cooling are disclosed. Devices and methods for operative temperature management are disclosed.

Abstract: An iridocorneal angle of the eye can be opened with a plurality of treatment locations at least about 2 mm radially outward from a limbus of the eye. The opening on the angle can be beneficial for treating both narrow angle glaucoma and open angle glaucoma. The plurality of treatment locations located away from the limbus can decrease invasiveness and complexity of the procedure. The plurality of treatment locations at least about 2 mm away from the limbus can provide tensioning to zonules coupled to the lens of the eye to flatten the lens of the eye, which can allow the iris to move posteriorly so as to open the iridocorneal angle. The plurality of treatment locations may comprise scleral locations, in which shrinkage of scleral tissue at the plurality of treatment locations provides tensioning to the zonules.

Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.