Patents Issued in November 12, 2020
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Publication number: 20200355576Abstract: A test cock for determining an operating condition of a backflow prevention system includes a body portion having a distal end and a proximal end and a space defined within the body portion. A distal opening is provided on the body portion at the distal end and a proximal opening is provided on the body portion at the proximal end and the proximal opening is in fluid connection with the body portion space. A body portion fitting is disposed in the body portion and is providing a fluid connection with the body portion space. A fluid sensor is coupled to the body portion fitting and is in fluid connection with the body portion space. A rotating system fitting has a first end and a second end where the second end is provided in the body portion proximal opening.Type: ApplicationFiled: May 8, 2020Publication date: November 12, 2020Applicant: Watts Regulator Co.Inventors: Joseph Michael Burke, Muhannad Bagegni, Jason Doughty, Frank DiBenedetto
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Publication number: 20200355577Abstract: A load transfer function of a uniformity measuring apparatus in a second state, in which a tire to be measured is attached, is obtained using at least either a load transfer function or an acceleration transfer function measured in a step of measuring reference transfer functions and a natural frequency measured in a step of measuring a natural frequency. The obtained load transfer function is used to correct tire uniformity data obtained by performing a certain type of signal processing on a tire uniformity waveform.Type: ApplicationFiled: April 13, 2020Publication date: November 12, 2020Applicant: KABUSHIKI KAISHA KOBE SEIKO SHO (KOBE STEEL, LTD.)Inventors: Toru OKADA, Keita KANAI
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Publication number: 20200355578Abstract: A tissue chip core-making system based on image recognition and positioning and a core-making method thereof—includes a cutting system and a computer control system. The cutting system includes a numerical control cutting machine, XYZ-axis translation worktables, a 360° rotation turntable, a recipient wax block rack, a freezing table and an image recognition and positioning module. A core-making process based on the core-making system includes: lofting, sample position recognition, tissue sample image acquisition, tissue sample image processing, cutting parameter setting, tissue sample cutting, tissue core information recognition and storage to obtain a tissue core with information traceability. The method obtains a coring region through visual recognition, and has the characteristics of high automation degree and high work efficiency.Type: ApplicationFiled: June 13, 2018Publication date: November 12, 2020Applicant: THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITYInventors: Bo LIU, Zhen WANG, Kehua GUO, Jian KANG, Xiangzhi SONG, Zhepeng XIAO, Zhuoyu LI, Kexin LONG, Lihua HUANG, Yichen GUO, Chaoyang SHEN
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Publication number: 20200355579Abstract: A sediment pressure-holding transfer device developed based on abyssal sediment fidelity sampler is disclosed, which uses a vacuum pump to discharge a gas in the device, uses a high-pressure pump as a power source to perform a pressurization process, uses gravity of a sample to perform a first transfer, and uses a high-pressure impurity pump and a safety valve to perform a second transfer of a sample mixture, in its structure, a high-pressure-resistant and corrosion-resistant material is used as a main material of the device, the device mainly comprises a mechanical system and a hydraulic system, the mechanical system is used as a main frame of the device and is a basis for ensuring operation of the device; the hydraulic system is used as a core of the device and is a key to ensure success of sediment transfer.Type: ApplicationFiled: May 9, 2019Publication date: November 12, 2020Inventors: Jiawang CHEN, Jing XIAO, Jiasong FANG, Weitao HE, Hao WANG, Yue HUANG, Wei WANG, Yuxia SUN
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Publication number: 20200355580Abstract: An air sample collection apparatus and methods for operating the air sample collection apparatus are provided. The air sample apparatus comprises a plurality of air canisters comprising at least a first canister and a second canister, a multi-position valve comprising an outlet, and an inlet region, which are fluidly connected to a plurality of ports. Each respective port is fluidly connected to a canister of the plurality of air canisters, a pump operable to provide pressurized sample air to the inlet region of the multi-position valve, and a computing device operable to open and close each respective port fluidly coupled to each canister of the plurality of canisters.Type: ApplicationFiled: May 8, 2019Publication date: November 12, 2020Applicant: University Corporation for Atmospheric ResearchInventor: Elizabeth ASHER
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Publication number: 20200355581Abstract: The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.Type: ApplicationFiled: December 19, 2018Publication date: November 12, 2020Applicant: LEICA BIOSYSTEMS MELBOURNE PTY LTDInventors: Zbigniew MIODUSZEWSKI, Aaron RIDGWAY, Matthew KING, Blake HELLARD
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Publication number: 20200355582Abstract: Systems, and methods that facilitate the performance of an assay of a sample substantially in real-time. Thus, the assay can be performed, and the desired result obtained, much more quickly than allowed by conventional systems and methods.Type: ApplicationFiled: August 1, 2018Publication date: November 12, 2020Inventor: Chao-Hsiang Wu
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Publication number: 20200355583Abstract: A tape for collecting tissue samples in a manner compatible with imaging in a transmission electron microscopy (TEM) system, includes a tape substrate having two side walls forming a trough. The trough is defined by a bottom surface of the tape substrate and internal surfaces of the side walls, with an open side therebetween. A support film is attached to a top surface of the tape substrate, and a plurality of apertures is spaced at predetermined locations along the length of the tape substrate, each aperture being covered by the support film. The tape includes a stacked configuration in which the tape substrate is wound in layers, the bottom surfaces of the side walls in one layer being in contact with the support film in an immediately adjacent layer. The apertures in the second layer are aligned within the trough of the first layer, between the side walls.Type: ApplicationFiled: April 18, 2017Publication date: November 12, 2020Applicant: President and Fellows of Harvard CollegeInventors: David Grant Colburn HILDEBRAND, Brett Jesse GRAHAM, Wei-Chung Allen LEE
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Publication number: 20200355584Abstract: An object of the present invention is to provide an analysis method in which a simple and accurate measurement result can be obtained even in a case where a sample (particularly, a sample having a low content of metal impurities) is coated on a substrate and the amount of metal impurities per unit area on the substrate is measured, a liquid chemical, and a method for producing a liquid chemical. The analysis method of the present invention includes: a step A of concentrating a sample containing at least one organic solvent and a metal impurity containing a metal atom at a predetermined rate to obtain a concentrated liquid; a step B of coating a substrate with the concentrated liquid to obtain a coated substrate; and a step C of measuring the number of the metal atom per unit area on the coated substrate by using a total reflection X-ray fluorescence analysis method and obtaining a measured value.Type: ApplicationFiled: July 30, 2020Publication date: November 12, 2020Applicant: FUJIFILM CorporationInventor: Tetsuya KAMIMURA
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Publication number: 20200355585Abstract: A sample separation device to introduce a sample to be separated to an inside of the sample separation device, centrifuge the sample, and collect a desired liquid after separation, includes: a sample introducing portion introducing the sample into the sample separation device; a liquid surface defining portion connected to the sample introducing portion; a first separating portion connected to the liquid surface defining portion; a second separating portion connected to the first separating portion; a third separating portion connected to the second separating portion; and a liquid extracting portion including the third separating portion and connected to the third separating portion, in which a tubular flow path is formed by at least the first separating portion and the second separating portion, in which an opening of the sample introducing portion and an opening of the liquid extracting portion are oriented in the same direction.Type: ApplicationFiled: November 2, 2018Publication date: November 12, 2020Inventors: Yu ISHIGE, Sakuichiro ADACHI, Takahiro ANDO
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Publication number: 20200355586Abstract: The analyzing method for quantifying urea in a sample solution includes: a pretreatment step of pretreating the sample solution with at least one of a membrane device including a reverse osmosis membrane and an ion exchange device including an ion exchanger; and an analyzing step of analyzing a target substance in the pretreated sample solution. The analyzing step is based on, for example, flow injection analysis (FIA), and includes a step of quantifying the target substance by measuring the absorbance of a liquid containing a substance generated by reacting the target substance with a reagent.Type: ApplicationFiled: October 30, 2018Publication date: November 12, 2020Applicant: ORGANO CORPORATIONInventors: Kazushige TAKAHASHI, Hiroshi SUGAWARA, Fumio SUDO, Katsuhisa SHIMADA
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Publication number: 20200355587Abstract: The present disclosure provides an apparatus for sampling at least one analyte from a sampling fluid. The apparatus includes: a solid-phase microextraction (SPME) sampling instrument. A connector is attached to the SPME sampling instrument and is coupleable to an aerial drone. The apparatus includes a protective cover that is sized and shaped to at least partially surround the SPME sampling instrument. The SPME sampling instrument and the protective cover are movable in relation to each other between a protecting configuration and a sampling configuration. The SPME sampling instrument and the protective cover are (i) biased in the protecting configuration when the density of the fluid surrounding the SPME sampling instrument is less than the density of the sampling fluid; and (ii) biased in the sampling configuration when the density of the fluid surrounding the SPME sampling instrument is equal to or greater than the density of the sampling fluid.Type: ApplicationFiled: May 8, 2020Publication date: November 12, 2020Inventor: Janusz PAWLISZYN
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Publication number: 20200355588Abstract: A method of pretreating a blood sample for measuring ATP of a pathogenic microorganism in blood, comprising: preparing a pellet of platelets and the pathogenic microorganism from the blood sample; and subjecting the pellet of platelets and the pathogenic microorganism to the following steps (A) to (C) in any order (including multiple simultaneous steps). A method of pretreating a cultured blood sample, wherein the method is a simplified method, does not comprise the following step (A), and comprises the steps (B) and (C) only simultaneously performed. (A) digesting cell membrane proteins of the platelets with a protease; (B) swelling the platelets in a hypotonic solution; and (C) disrupting cell membranes of the platelets with a detergent solution under a condition of suppressing an effect on the pathogenic microorganism.Type: ApplicationFiled: May 14, 2020Publication date: November 12, 2020Inventors: Hideki NIIMI, Kazushige SUGIE, Isao KITAJIMA, Tomohiro UENO, Atsushi MATSUI
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Publication number: 20200355589Abstract: An automatic sample preparation apparatus that automatically prepares a sample piece from a sample includes: a focused ion beam irradiation optical system configured to irradiate a focused ion beam; an electron beam irradiation optical system configured to irradiate an electron beam from a direction different from a direction of the focused ion beam; a sample piece transfer device configured to hold and transfer the sample piece separated and extracted from the sample; a detector configured to detect secondary charged particles emitted from an irradiation object by irradiating the irradiation object with the focused ion beam and/or the electron beam; and a computer configured to recognize a position of the sample piece transfer device by image-recognition using an image data of the focused ion beam and the electron beam generated by irradiating the sample piece transfer device with the focused ion beam and the electron beam, and drive the transfer device.Type: ApplicationFiled: July 22, 2020Publication date: November 12, 2020Inventors: Atsushi Uemoto, Tatsuya Asahata, Makoto Sato, Yo Yamamoto
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Publication number: 20200355590Abstract: The present invention discloses a system for measuring the mechanical properties of sea floor sediments at full ocean depth.Type: ApplicationFiled: April 1, 2019Publication date: November 12, 2020Applicant: OCEAN UNIVERSITY OF CHINAInventors: Yonggang JIA, Hong ZHANG, Xiaolei LIU, Hongxian SHAN
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Publication number: 20200355591Abstract: In order to permit a robust, energy-efficient and precise moisture sensor, the invention relates to a moisture sensor element (10) for a moisture sensor (12) for measuring a moisture content in a gas, comprising at least one vibrating element (14) and at least one material (16, 18) on the vibrating element (14), wherein the at least one material (16, 18) is designed in such a way that the mass thereof changes rapidly with moisture changing over a moisture value. The invention also relates to a moisture-measuring method for measuring a moisture in a gas, comprising: using a moisture sensor element (10), wherein the course of the measurement signal thereof has at least one non-linearity according to the moisture; and determining a reference value based on the at least one non-linearity.Type: ApplicationFiled: November 19, 2018Publication date: November 12, 2020Inventor: Wendelin J. STARK
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Publication number: 20200355592Abstract: A method for determining the oxygen surface exchange property of a material in a solid oxide fuel cell. The method begins by first receiving a data stream comprising of continuous weight measurements of the material and time measurements of when the continuous weight measurements of the material are taken. While receiving the data stream an oxygen concentration test is performed which involves: flowing a degradation gas flow onto the cathode material while simultaneously increasing the temperature of the primary gas flow to a set temperature, flowing the degradation gas flow onto the material at the set temperature, stopping the degradation gas flow and starting a primary gas flow at the set temperature, flowing the primary gas flow onto the material at the set temperature, and stopping the primary gas flow and starting a secondary gas flow at the set temperature. This data stream is then displayed analyzing the weight change of the material over time.Type: ApplicationFiled: April 29, 2020Publication date: November 12, 2020Applicant: PHILLIPS 66 COMPANYInventors: Ye Lin, Ying Liu, Paul Michael Alvey
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Publication number: 20200355593Abstract: The present disclosure provides a low-cost and accurate rheometer system and method capable of determining melt flow rheological properties of polymers, such as from Fused Filament Fabrication (“FFF”) polymeric materials. The device can include a filament feeding system, liquefier for filament melting, force transducer for measuring filament feeding force, and a temperature control system for controlling polymer melt temperatures. An electronic control system can capture data and manage operations. The system can measure a filament velocity and filament force required to extrude the FFF filament for printing. The filament velocity and force data can be used to compute data sets of melt volumetric flow relative to pressure drop across a FFF nozzle.Type: ApplicationFiled: May 6, 2019Publication date: November 12, 2020Applicant: BAYLOR UNIVERSITYInventors: Douglas E. Smith, Jingdong Chen
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Publication number: 20200355594Abstract: A method of controlling a particle size distribution of a filler in an extrudable composition comprises introducing an extrudable composition comprising a polymer matrix material and a filler into an extruder, the filler having a first average particle size that is larger than a target average particle size. The extrudable composition is extruded one or more times using the extruder to reduce the size of the filler from the first average particle size to a reduced average particle size, the reduced average particle size being within 10% of the target average particle size.Type: ApplicationFiled: May 6, 2019Publication date: November 12, 2020Applicant: The Boeing CompanyInventors: Eric Alan Bruton, Loyal Bruce Shawgo
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Publication number: 20200355595Abstract: The invention relates to a method for producing seed-like solid particles from at least one, but typically two starting substances, wherein the produced particles are optically detected by means of an optical detection system, wherein data of the produced particles detected optically by the optical detection system is provided, and at least one, but typically two parameters of the produced particles are determined from the optically detected data of the produced particles, wherein at least one, but typically two optically determined parameters automatically synergetically influence the production process of further particles on the basis of the optically detected data of the produced particles. The invention further relates to a device for carrying out the method and a computer program for carrying out the method.Type: ApplicationFiled: November 2, 2018Publication date: November 12, 2020Applicant: K+S AKTIENGESELLSCHAFTInventors: Paul MEISSNER, David SCHERR, Maik KLOTZBACH, Guido BAUCKE
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Publication number: 20200355596Abstract: A device (100) includes a flow channel (115) having a first end (120) to receive fluid flow (122) and a second end (125) to exhaust fluid flow (127), the flow channel (115) having a flow channel opening (135). A piston (130) is disposed within the flow channel (115), the piston (130) having a piston passage (140) to allow airflow through the piston (130). A spring (132) is coupled to the piston (130) and coupled to the flow channel (115). The spring (132) is positioned to allow the piston (130) to move responsive to fluid flow velocity in the flow channel (115), wherein the piston (130) moves to modulate fluid flow through the flow channel opening (135).Type: ApplicationFiled: August 24, 2017Publication date: November 12, 2020Inventors: Kevin CAI, Kai HUANG, Marilyn WANG, Wesley NIE
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Publication number: 20200355597Abstract: An air sampling device for collecting and analyzing airborne particulate matter. The air sampling device may include a housing, an air intake aperture in the housing where air enters an interior of the housing, a collection surface, disposed within the housing, that captures airborne particulate matter contained in the air, and an imaging device that captures an image of the airborne particulate matter collected on the collection surface. The device may also include a microscope for viewing the airborne particulate matter collected on the collection surface. The imaging device captures an image of the airborne particulate matter collected on the collection surface. The imaging device views and captures an image of the airborne particulate matter collected on the collection surface through the microscope.Type: ApplicationFiled: May 11, 2020Publication date: November 12, 2020Applicant: Pollen Sense LLCInventors: Nathan Allan, Kevn Lambson, Richard Lucas, Landon Bunderson
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Publication number: 20200355598Abstract: An experimental testing device and method for dynamic imbibition capacity of shale are provided.Type: ApplicationFiled: July 24, 2020Publication date: November 12, 2020Applicant: SOUTHWEST PETROLEUM UNIVERSITYInventors: Jianchun Guo, Liang Tao, Chi Chen, Zhihong Zhao, Ming Li, Pengcheng Tang
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Publication number: 20200355599Abstract: Provided herein are optical systems and methods for detecting and characterizing particles. Systems and method are provided which increase the sensitivity of an optical particle counter and allow for detection of smaller particles while analyzing a larger fluid volume. The described systems and methods allow for sensitive and accurate detection and size characterization of nanoscale particles (e.g., less than 50 nm, optionally less than 20 nm, optionally less than 10 nm) for large volumes of analyzed fluids.Type: ApplicationFiled: April 24, 2020Publication date: November 12, 2020Applicant: PARTICLE MEASURING SYSTEMS, INC.Inventors: Daniel RODIER, James LUMPKIN, Dwight SEHLER, Brian KNOLLENBERG
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Publication number: 20200355600Abstract: According to one aspect, an apparatus includes a first printed circuit board (PCB), the first PCB including a first interface, and a corrosion sensor assembly. The corrosion sensor assembly including a second interface arranged to be coupled to the first interface, the corrosion sensor assembly further including a signal trace field and a plurality of components, wherein the signal trace field and the plurality of components are arranged to provide an indication of whether the apparatus is in an environment that is corrosive.Type: ApplicationFiled: July 28, 2020Publication date: November 12, 2020Applicant: CISCO TECHNOLOGY, INC.Inventors: Joel Goergen, Robert Gregory Twiss, Elizabeth Kochuparambil
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Publication number: 20200355601Abstract: A method for identifying corrosion under insulation (CUI) in a structure comprises receiving thermographs from the structure using an infrared camera, applying filters to the thermograph using a first machine learning system, initially determining a CUI classification based on output from the filters, and validating the initial CUI classification by an inspection of the structure. The first machine learning system is trained using results of the validation. Outputs of the first machine learning system and additional structural and environmental data are fed into a second machine learning system that incorporates information from earlier states into current states. The second machine learning system is trained to identify CUI according to changes in the outputs of the first machine learning system and the additional data over time until a second threshold for CUI classification accuracy is reached. CUI is thereafter identified using the first and second machine learning systems in coordination.Type: ApplicationFiled: July 30, 2020Publication date: November 12, 2020Inventors: Ayman Amer, Ali Al Shehri, Brian Parrott, Mohammed Sarraj
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Publication number: 20200355602Abstract: A gas sensor includes a multi-wafer stack of a plurality of layers and a measurement chamber. The plurality of layers includes a first layer comprising a sensor element that has a microelectromechanical system (MEMS) membrane; and a second layer comprising an emitter element configured to emit electromagnetic radiation. The measurement chamber is interposed between the first layer and the second layer. The measurement chamber is configured to receive a measurement gas and further receive the electromagnetic radiation emitted by the emitter element as the electromagnetic radiation travels along a radiation path from a first end of the measurement chamber to a second end of the measurement chamber that is opposite to the first end.Type: ApplicationFiled: July 31, 2020Publication date: November 12, 2020Applicants: Infineon Technologies AG, Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.Inventors: Stefan KOLB, Alfons DEHE, Jochen HUBER, Franz JOST, Horst THEUSS, Wilhelm WIEDMEIER, Juergen WOELLENSTEIN
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Publication number: 20200355603Abstract: In accordance with an example aspect of the present invention, there is provided a method of obtaining a calibrated measurement of a sample using an integrating cavity, comprising obtaining sample spectral information by using the integrating cavity with the sample placed inside the integrating cavity, obtaining cavity-characterizing spectral information generated by using the integrating cavity with a standard object, and obtaining a measurement result from the sample spectral information by employing a mathematical process that takes the cavity-characterizing spectral information as input.Type: ApplicationFiled: January 29, 2019Publication date: November 12, 2020Inventor: Ralf Marbach
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Publication number: 20200355604Abstract: The invention relates to a device (1) and a corresponding method for mid-infrared microscopy and/or analysis, the device (1) comprising at least one radiation unit (10) configured to generate radiation (11) of time-varying intensity, the radiation (11) comprising one or more wavelengths in the mid-infrared spectral range, at least one refractive and/or reflective optical unit (12) which is configured to focus and/or direct the radiation (11) to at least one region or point of interest (20) located on and/or within an object (2), at least one detection unit (18) configured to detect ultrasound waves (17) emitted by the object (2) at the at least one region or point of interest (20) in response to an interaction of the radiation (11) with the object (2) and to generate according detection signals, and an evaluation unit (25) configured to derive information regarding at least one property of the object (2) from the detection signals and/or to generate a spatial and/or spatio-temporal distribution of the detectiType: ApplicationFiled: January 30, 2019Publication date: November 12, 2020Inventors: Vasilis Ntziachristos, Miguel Angel Pleitez Rafael
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Publication number: 20200355605Abstract: Systems and method are disclosed for measuring an analyte (e.g., glucose) in a fluid (e.g., blood) using a tunable source. The system can draw blood from a patient and deliver the blood to a sample cell. Some or a particular component of the fluid (e.g., plasma) may be positioned at a sample portion of the sample cell for measurement. The sample cell can include a cuvette with two window pieces defining a gap for fluid analysis. Wider gaps can facilitate measurement of larger biological fluid components, and laser optical sources can provide sufficient power to traverse larger gaps. Tunable sources can provide for measurement of a wider variety of components. Aspects of the system can be adjusted to accommodate measurement of multiple analytes with multiple wavelengths.Type: ApplicationFiled: March 5, 2020Publication date: November 12, 2020Inventor: James D. Causey, III
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Publication number: 20200355606Abstract: An optical refraction barometer measures pressure based on refractivity changes and includes: an optical light source; an optical frequency controller; a first optical phase controller; a first polarization controller; an electronic reference arm in optical communication with the first polarization controller; a second optical phase controller in optical communication with the optical frequency controller; a second polarization controller in optical communication with the second optical phase controller; an electronic sample arm in optical communication with the second polarization controller and in electrical communication with the second optical phase controller; a second sideband frequency generator; a mixer in electrical communication with the detector and the second sideband frequency generator; and a first sideband frequency generator in electrical communication with the mixer; and a dual fixed length optical cavity refractometer.Type: ApplicationFiled: July 24, 2020Publication date: November 12, 2020Inventors: Kevin O'Connell Douglass, Stephen Paul Eckel, Jacob Edmond Ricker, Jay Howard Hendricks
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Publication number: 20200355607Abstract: The present application relates to the measurement technology of the homogeneity in optical materials, and more particularly to a method for evaluating and controlling temperature influence on a homogeneity test for infrared optical materials. The precision of the test results is found to be affected by local small temperature changes of the sample during the homogeneity test for the refractive indexes of infrared optical materials, the invention establishes a two-dimensional numerical table in which the test precision requirements of a refractive index homogeneity test for infrared optical materials correspond to the ambient control temperatures in the test room corresponding to the influence of temperature changes on the refractive index of different infrared optical materials. In addition, related calculation formulas are established for theory analysis, numerical calculation and form-designing.Type: ApplicationFiled: July 27, 2020Publication date: November 12, 2020Inventor: Lyubo Mai
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Publication number: 20200355608Abstract: An optical testing device for use in testing an optical measuring instrument provides incident light from a light source to an incident object and receives reflected light due to reflection of the incident light at the incident object. The optical testing device includes an incident light receiving section that receives incident light, and a light signal providing section. The light signal providing section provides a light signal to the incident object after a predetermined delay time since the incident light receiving section has received the incident light. A reflected light signal due to reflection of the light signal at the incident object is provided to the optical measuring instrument. The delay time is approximately equal to the time between emission of the incident light from the light source and reception of the reflected light by the optical measuring instrument in the case of actually using the optical measuring instrument.Type: ApplicationFiled: April 1, 2020Publication date: November 12, 2020Applicant: ADVANTEST CORPORATIONInventors: Toshihiro SUGAWARA, Shin MASUDA, Takao SAKURAI, Hidenobu MATSUMURA, Takao SEKI
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Publication number: 20200355609Abstract: An imaging reflectometer includes a source module configured to generate a plurality of input beams at different nominal wavelengths. An illumination pupil having a first numerical aperture (NA) is arranged so that each of the plurality of input beams passes through the illumination pupil. A large field lens is configured to receive at least a portion of each of the plurality of input beams and provide substantially telecentric illumination over a sample being imaged. The large field lens is also configured to receive reflected portions of the substantially telecentric illumination reflected from the sample. The reflected portions pass through an imaging pupil having a second NA that is lower than the first NA and are received by an imaging sensor module that generates image information.Type: ApplicationFiled: July 31, 2020Publication date: November 12, 2020Inventors: Guoheng Zhao, Mehdi Vaez-lravani, Todd J. Egan
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Publication number: 20200355610Abstract: A method for measuring optical signal detector performance that includes directing light emitted from an optical signal detector onto a first non-fluorescent surface portion in a first detection zone of the optical signal detector. A first characteristic of light detected by a first sensor of the first optical signal detector is measured while the first non-fluorescent surface portion is in the first detection zone of the optical signal detector. Light emitted from the optical signal detector is directed into a first void in the first detection zone of the optical signal detector. A second characteristic of light detected by the first sensor of the optical signal detector is measured while the first void is in the first detection zone of the optical signal detector. And an operational performance status of the optical signal detector is determined based on at least one of the first characteristic and the second characteristic.Type: ApplicationFiled: July 24, 2020Publication date: November 12, 2020Inventors: David OPALSKY, Srajan RAGHUWANSHI, James BUI
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Publication number: 20200355611Abstract: A label-free detection and characterization system includes an optical source; an optical path arranged to be optically coupled to the optical source; an optical resonator disposed proximate the optical path along a side of the optical path, the optical resonator having an optical whispering-gallery mode and being optically coupled to the optical path through an evanescent field to excite the optical whispering-gallery mode; an optical receiver arranged to be optically coupled to the optical path. The optical source is frequency locked to a resonance frequency of the optical resonator and provides light sufficiently intense to provide four-wave mixing while being coupled with the optical resonator resulting in a comb spectrum received by the optical receiver. The comb spectrum provides characteristic changes in the presence of a substance in contact with the optical resonator to provide detection and characterization of the substance.Type: ApplicationFiled: February 7, 2019Publication date: November 12, 2020Applicant: Arizona Board of Regents on Behalf of the University of ArizonaInventor: Tsu-Te Judith SU
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Publication number: 20200355612Abstract: In-situ fluorimeters and methods and systems for collecting and analyzing sensor data to predict water source contamination are provided. In one embodiment, a method is provided that includes receiving sensor data regarding a water source. Changepoints may then be calculated within the sensor data and the sensor data may be split into intervals at the changepoints. A machine learning model may then be used to classify the intervals and a predicted contamination event for the water source may be identified based on the classified intervals. In another embodiment, an in-situ fluorimeter is provided. The in-situ fluorimeter comprises one or more UV LEDs centered around a pre-set excitation wavelength (e.g., a TLF excitation wavelength), a bandpass filter, a lens, a photodiode system, a machine learning platform; and an alarm triggered by contamination events, wherein the alarm is calibrated through the machine learning system.Type: ApplicationFiled: February 28, 2020Publication date: November 12, 2020Inventors: Evan Thomas, Taylor Sharpe, Emily Bedell, Daniel Wilson, Jeremy Coyle
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Publication number: 20200355613Abstract: Embodiments generally relate to a system for reading fluorescent-labelled diagnostic assays for in-vitro diagnostic applications. The system comprises a receiving member adapted to receive a fluorescent-labelled diagnostic assay cartridge carrying a fluorescent-labelled diagnostic assay; at least one excitation module configured to illuminate the diagnostic assay, when the diagnostic assay cartridge is placed in the receiving member; a camera module for capturing an image of the illuminated diagnostic as—say placed in the receiving member; a processor for receiving the captured image from the camera module and determining whether or not a target analyte was present in the diagnostic assay captured by the camera module; and memory storing firmware, the firmware including a brightness compensation module configured to adjust the intensity of an image of a diagnostic cartridge captured by the camera module, in order to emulate a uniform field of illumination over the diagnostic cartridge.Type: ApplicationFiled: July 30, 2020Publication date: November 12, 2020Inventor: William Samuel Hunter
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Publication number: 20200355614Abstract: A system for manipulating a biological sample, and a method for operating such a system. The system includes an imaging device arranged to image a biological sample; a controller operably connected with the imaging device for processing the images obtained by the imaging device; and a tool manipulation device operably connected with the controller and arranged to be connected with a tool for manipulating the biological sample. The controller is arranged to control operation of the tool manipulation device based on the processing of the images.Type: ApplicationFiled: May 8, 2019Publication date: November 12, 2020Inventors: Dong Sun, Wendi Gao
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Publication number: 20200355615Abstract: The present invention relates to a target gene-detecting device and a method for detecting a target gene. According to an aspect, a target gene-detecting device can be conveniently fabricated at low cost by employing a porous substrate or a method for detecting a target gene allows the pretreatment of a sample, the extraction of a nucleic acid, the amplification of a nucleic acid, and the detection of a target gene to be conducted at high accuracy and specificity in an integral system, with no contamination plausibility and can be thus useful for gene inspection.Type: ApplicationFiled: August 28, 2018Publication date: November 12, 2020Applicant: Samsung Life Public Welfare FoundationInventors: Min Young LEE, Min Hee KANG, Hyun Ju PARK, Dong Ho KIM, Sung Gyu PARK, Ho Sang JUNG
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Publication number: 20200355616Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.Type: ApplicationFiled: July 29, 2020Publication date: November 12, 2020Applicant: Meso Scale Technologies, LLC.Inventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
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Publication number: 20200355617Abstract: A wearable sensor has threads that are coated with a polymer coating. Each thread has an optically-responsive chemical dye entrapped thereon. Each of the dyes is selected emit electromagnetic radiation upon exposure to a selected analyte.Type: ApplicationFiled: September 27, 2018Publication date: November 12, 2020Inventors: Sameer Sonkusale, Rachel Owyeung
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Publication number: 20200355618Abstract: Examples of gemstone verification are described herein. In one example, for processing a gemstone, pre-stored marking coordinates associated with a gemstone ID are obtained, the pre-stored marking coordinates generated during planning phase of the processing. Further, real-time marking coordinates for the gemstone to be processed are also obtained. An identity of the gemstone is verified based on a comparison of the pre-stored marking coordinates with the real-time marking coordinates. Further, information, including cutting parameters, associated with the gemstone ID of the gemstone is retrieved in response to a valid verification of the identity of the gemstone, for processing the gemstone.Type: ApplicationFiled: December 24, 2018Publication date: November 12, 2020Inventors: Munjal Dhirajlal Gajjar, Chetan Fulchandhai Patel, Piyush Himmatbhai Vaishnani, Rahul Mahendrakumar Gaywala
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Publication number: 20200355619Abstract: A handheld device for making 3D topography measurements of surface discontinuities in high performance structures, such as aerostructures (e.g., aluminum fuselages). Lights illuminate the discontinuity from multiple angles, and a camera captures images of the discontinuity. A thickness sensor generates thickness data regarding a thickness of the base material and the top protective coating. A position sensor generates position data regarding a location of the discontinuity on the structure. A processor generates geometry data regarding a geometry of the discontinuity based on the images, performs an analysis of the geometry, thickness, and position data, and communicates a result of the analysis on a display. A conforming membrane and/or a gel and an opaque lubricant may be applied over and conform to the discontinuity in order to make more uniform a reflectivity difference and a color difference between the discontinuity and an adjacent portion of the structure.Type: ApplicationFiled: July 30, 2020Publication date: November 12, 2020Applicant: SPIRIT AEROSYSTEMS, INC.Inventor: Mark Davis Haynes
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Publication number: 20200355620Abstract: A method for determining a defect material element, the method includes (a) acquiring, by a charged particle beam system and by applying a spectroscopy process, an electromagnetic emission spectrum of a part of a defect; (b) acquiring, by the charged particle beam system, a backscattered electron (BSE) image of an area that includes the defect; and (c) determining a defect material element. The determining of the defect material element includes: determining whether an ambiguity exists in the electromagnetic emission spectrum, and resolving the ambiguity based on the BSE image, when it is determined that the ambiguity exists.Type: ApplicationFiled: May 7, 2019Publication date: November 12, 2020Applicant: APPLIED MATERIALS ISRAEL LTD.Inventors: Dror Shemesh, Eugene T. Bullock, Adi Boehm, Gurjeet Singh
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Publication number: 20200355621Abstract: Strontium tetraborate is used as an optical coating material for optical components utilized in semiconductor inspection and metrology systems to take advantage of its high refractive indices, high optical damage threshold and high microhardness in comparison to conventional optical materials. At least one layer of strontium tetraborate is formed on the light receiving surface of an optical component's substrate such that its thickness serves to increase or decrease the reflectance of the optical component. One or multiple additional coating layers may be placed on top of or below the strontium tetraborate layer, with the additional coating layers consisting of conventional optical materials. The thicknesses of the additional layers may be selected to achieve a desired reflectance of the optical component at specific wavelengths. The coated optical component is used in an illumination source or optical system utilized in a semiconductor inspection system, a metrology system or a lithography system.Type: ApplicationFiled: March 16, 2020Publication date: November 12, 2020Inventors: Yung-Ho Alex Chuang, Yinying Xiao-Li, Elena Loginova, John Fielden
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Publication number: 20200355622Abstract: A method for use in optical measurements on patterned structures, the method including performing a number of optical measurements on a structure with a measurement spot configured to provide detection of light reflected from an illuminating spot at least partially covering at least two different regions of the structure, the measurements including detecting light reflected from the at least part of the at least two different regions within the measurement spot, the detected light including interference of at least two complex electric fields reflected from the at least part of the at least two different regions, and being therefore indicative of a phase response of the structure, carrying information about properties of the structure.Type: ApplicationFiled: May 26, 2020Publication date: November 12, 2020Inventors: GILAD BARAK, DROR SHAFIR, YANIR HAINICK, SHAHAR GOV
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Publication number: 20200355623Abstract: The present application relates to the measurement technology of the striae in optical materials, and more particularly to a quantitative test method for the striae in optical materials. The method includes: establishing a concept and algorithm of the striae quantitative expression; establishing a gray ruler of striae quantitative measurement and standard proof samples to calibrate a photoelectric projection measurement apparatus equipped with a photoelectric image sensor; imaging a measurement sample with the calibrated photoelectric projection measurement apparatus and obtaining the striae image of the measurement sample thereof and determining values of the parameters of the area and gray of the striae image; and inputting the values into the algorithm to calculate the striae value of the measurement sample.Type: ApplicationFiled: July 23, 2020Publication date: November 12, 2020Inventor: Lyubo Mai
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Publication number: 20200355624Abstract: The present invention relates to projection and schlieren optical measurement technology, and more particularly to an integrated projection-schlieren optical system. The system includes a parallel light source system, a first positive lens, a diaphragm, a second positive lens, an image sensor, a negative lens, a knife edge device and a sample stage. In the system, a projection telescopic optical system and a schlieren camera optical system are respectively formed through the combination of optical characteristics of two movable lenses, enabling the integration functions of the projection optical system and the schlieren optical system.Type: ApplicationFiled: July 27, 2020Publication date: November 12, 2020Inventor: Lyubo Mai
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Publication number: 20200355625Abstract: Disclosed is a method for controlling surface errors of a sample in a homogeneity measurement of infrared optical materials. In this invention, a calculation relationship among the surface errors, measurement principles and precision requirements is established. The wavefront distortion caused by the surface errors of the sample measured in infrared wavebands is converted to the surface errors of the sample which is processed and inspected under the visible light. Through establishing related algorithms and formulas for numerical calculations, a numerical table for controlling the surface errors of the sample is created to ensure the precision of the homogeneity measurement for the infrared optical material under short, middle and long wavebands. A case table for controlling the surface errors of the sample is also provided to ensure the precision of the homogeneity measurement for the specific infrared optical materials under short, middle and long wavebands.Type: ApplicationFiled: July 27, 2020Publication date: November 12, 2020Inventor: Lyubo Mai