Abstract: A system for monitoring autoregulation may include processing circuitry configured to receive a blood pressure signal indicative of an acquisition blood pressure of a patient at an acquisition site and an oxygen saturation signal indicative of an oxygen saturation of the patient. The processing circuitry may determine a cerebral autoregulation status value based on the blood pressure signal and the oxygen saturation signal. The processing circuitry may determine a non-cerebral autoregulation status value based on the cerebral autoregulation status value and an adjustment value. The processing circuitry provide to an output device a signal indicative of the non-cerebral autoregulation status value and a signal indicative of the cerebral autoregulation status value to enable a clinician to monitor the autoregulation status of the patient.

Abstract: Devices and methods for monitoring physiologic parameters are described herein which may utilize a non-invasive respiratory monitor to detect minor variations in expiratory airflow pressure known as cardiogenic oscillations which are generated by changes in the pulmonary blood volume that correspond with the cardiac cycle. These cardiogenic oscillations are a direct indicator of cardiac function and may be used to correlate various physiologic parameters such as stroke volume, pulmonary artery pressure, etc.

Abstract: An air circuit structure comprises the air circuit box, an air charging pump, a cuff air nozzle, air discharging valves and an air pressure examination sensor. The air circuit box comprises a shell with a cavity formed inside. The shell is provided with an access port, an air charging port and an air inlet port spaced apart, and the access port, the air charging port and the air inlet port are all connected to the cavity.

Abstract: Techniques for determining pulse transit time (PTT) and blood pressure measurements based on stethoscope data are provided. In one example, a system comprises a stethoscope component that monitors a heart and generates stethoscope data representative of a sound wave generated by the heart. The system can further comprise an analysis component that receives the stethoscope data and receives, from a photoplethysmography (PPG) component that monitors an extremity, PPG data representative of a pulse wave at the extremity. The analysis component can determine, based on the stethoscope data, a first time corresponding to closure of a tricuspid valve of the heart and can determine a PTT as a function of the first time and a second time corresponding to the pulse wave at the extremity that is determined based on the PPG data. Blood pressure measurements can be obtained from algorithms with the inputs of PTT or times determined based on the PPG data.

Abstract: Methods, systems, and storage media relating to a circulatory health monitor device are disclosed herein. In an embodiment, such a device may be positioned or disposed on and/or in contact with a subject to measure blood pressure and/or heart rate. The device may include one or more electrocardiographic (ECG) signal sensors, one or more photoplethysmographic (PPG) sensors, and a controller. The controller may activate at a low resolution a PPG measurement of the subject in relation to an ECG signal feature to identify a PPG signal feature location or region in the PPG measurement. The controller may further activate at a high resolution PPG measurement of the subject at the PPG signal feature region to identify the PPG signal feature, and may determine blood pressure and/or heart rate therefrom. Other embodiments may be disclosed and/or claimed.

Abstract: Intravascular devices, systems, and methods are disclosed. In some embodiments, the intravascular devices include at least one mounting structure within a distal portion of the device. In that regard, one or more electronic, optical, and/or electro-optical component is coupled to the mounting structure. In some instances, the mounting structure is formed of a plurality of material layers. In some embodiments, the material layers have substantially constant thicknesses. Methods of making and/or assembling such intravascular devices/systems are also provided.

Abstract: A pressure sensing guidewire includes a distal end and a proximal end. The guidewire includes a tubular member having a distal portion and a proximal portion. The guidewire includes an optical pressure sensor disposed within the distal portion of the tubular member, and a polymer fiber optic cable extending proximally from the optical pressure sensor. The optical pressure sensor is located at a position that is about 3 centimeters or less from the distal end of the pressure sensing guidewire.

Abstract: The present disclosure relates to a device, method and system (100) for calculating, estimating, or monitoring the physiological parameters of a subject. At least one processor, when executing instructions, may perform one or more of the following operations: receiving a first signal representing a pulse wave relating to heart activity of a subject, receiving a plurality of second signals representing time-varying information on the pulse wave, determining a blood oxygen level of the subject based on the plurality of second signals, identifying a first feature in the first signal, identifying a second feature in one of the plurality of second signals, computing a pulse transit time based on a difference between the first feature and the second feature, calculating a blood pressure of the subject based on the pulse transit time.

Abstract: Provided is an optical unit that radiates a coherent light such that the coherent light is incident in a target region of speckle image capturing in accordance with a pattern that includes a bright region and a dark region located uniformly in at least one direction in the target region. Provided is a measurement system including: an optical unit that radiates a coherent light such that the coherent light is incident in a target region in accordance with a pattern that includes a bright region and a dark region located uniformly in at least one direction in the target region; a light reception unit that receives a reflected light of the coherent light in the target region; and an imaging unit that captures an image of a speckle included in the reflected light.

Abstract: A method and system for sensing respiration in the treatment of sleep apnea is disclosed.

Abstract: A needle electrode fixation device is configured to secure a transdermal needle electrode to a patient. The device includes a base having a body that defines a first portion and a second portion. The first and second portions are rotatable relative to each other. The first portion defines a channel configured to fit a portion of the transdermal needle electrode. The second portion defines a recess configured to fit a tip of the needle electrode. The device further includes an adhesive layer configured to affix the base to the patient.

Abstract: In some embodiments, a microelectronic sensor includes an open-gate pseudo-conductive high-electron mobility transistor and used for air quality monitoring. The transistor comprises a substrate, on which a multilayer hetero-junction structure is deposited. This hetero-junction structure comprises a buffer layer and a barrier layer, both grown from III-V single-crystalline or polycrystalline semiconductor materials. A two-dimensional electron gas (2DEG) conducting channel is formed at the interface between the buffer and barrier layers and provides electron current in the system between source and drain electrodes. The source and drain contacts are non-ohmic (capacitively-coupled) and connected to the formed 2DEG channel and to the electrical metallizations, the latter are placed on top of the transistor and connect it to the sensor system. The metal gate electrode is placed between the source and drain areas on or above the barrier layer, which may be recessed or grown to a specific thickness.

Abstract: This disclosure is directed to a catheter having a multi-electrode assembly with a high electrode density. The multi-electrode assembly may be a basket-shaped electrode assembly or a brush-shaped electrode assembly each having a plurality of spines. Each spine includes a flexible wire core of a shape memory material. The flexible wires may have variable cross-section s to control the movement and stiffness of the spines.

Abstract: A system includes an electrical interface and a processor configured to receive, via the electrical interface, a signal sensed by at least one electrode in contact with tissue of a subject's heart, the signal spanning successive time periods that are each of length T1 and including multiple signal points, to calculate respective thresholds for the time periods, to select a set of points that includes, for each of the time periods, a signal point of greatest magnitude in the time period, provided that the greatest magnitude is greater than the threshold for the time period, to remove, from the set, one of any pair of the selected points that are within an interval T2 of one another, T2 being less than T1, and to generate, subsequently to the removing, an output that is based on the points remaining in the set corresponding to respective electrical activations of the tissue.

Abstract: This document discusses, among other things, systems and methods to determine amplitude and morphology variations of a first heart sound over a first number of cardiac cycles, and to calculate an atrial fibrillation metric indicative of an atrial fibrillation episode of the heart using the determined amplitude and morphology variations. The systems and methods can determine a variability score using the determined amplitude and morphology variations, and can calculate the atrial fibrillation metric using the variability score.

Abstract: Systems and methods are described for enhancing sensorimotor learning using EEG decoding and closed-loop neuromodulation. A plurality of EEG electrodes and a plurality of stimulation electrodes are coupled to a learning subject. An output device of an adaptive learning system provides a sequence of instructions to the learning subject for performing a sensorimotor task in accordance with a defined learning schedule. The defined learning schedule is adjusted based on a monitored EEG signal while performing the task and, in some implementations, a neuromodulation stimulus signal is applied to the learning subject that is designed to cause the monitored EEG signal of the learning subject to approach at least one target EEG signal parameter.

Abstract: System for registering a coordinate system associated with a pre-acquired model of an object with a reference coordinate system. The system includes a portable unit which includes a display, a tracking system for tracking the portable unit and a processor. The processor is coupled with the portable unit and with the tracking system. The processor determines the position and orientation of the portable unit. The processor further determines the position of at least one marker located on the object according to at least one of, a tracked pointer and respective position related information. The processor further displays registration related information on the display. At least one of the registration related information and the display location of the registration related information are related to the position and orientation of the portable unit. The position of the at least one marker, in the coordinate system associated with the pre-acquired model, is predetermined.

Abstract: A position detection system includes: a detection target; detection coils each outputting a detection signal of strength of the alternating magnetic field; a guidance magnetic field generator including a magnetic field generation source, and a driving mechanism, wherein at least a part of the guidance magnetic field generator is formed of a conductor that generates an interference magnetic field; and a processor configured to: control an operation of the driving mechanism; calculate a correction value by using at least one of a position and a posture of the conductor; correct the measured value by using the correction value; and calculate at least one of a position and a posture of the detection target based on the corrected measured value.

Abstract: A surgical tool having an electromagnetic (EM) sensor component is provided. The surgical tool has a flexible shaft portion. Additionally, the surgical tool has a rigid portion attached to the flexible shaft portion. The rigid portion comprises at least one EM sensor within the rigid portion. The at least one EM sensor comprises an extended core portion surrounded by a coil. Additionally, the at least one EM sensor generates a change in voltage when exposed to an electromagnetic field.

Abstract: A gas flow-focusing device (FFD) may include a cylindrical body that may include a funneling part to receive exhaled CO2-enriched air, and a CO2 sampling part. The CO2 sampling part and the funneling part are in fluid flow communication. The CO2 sampling part may include a CO2 sampling chamber to accept the CO2-enriched air, and a CO2 sampling tube to sample the CO2-enriched air. The funneling part and the CO2 sampling part may structurally form between them a ring-shaped gas chamber to contain a pressurized propellant gas, and a hollow channel in order to channel the pressurized propellant gas from the gas chamber to the CO2 sampling chamber. The gas chamber may include a gas intake opening through which propellant gas may fill the gas chamber. A prong-free cannula (PFC) may include two FFDs for sampling CO2, and a plurality of apertures for providing, there through, oxygen.

Abstract: A device for evaluating the microcirculation of blood in human or animal tissue. The device having a housing with an open end for contact with said tissue and thus delimit a study area of said tissue. The device including a light-emission means toward the study area, image-acquisition means of the study area, compression means of at least one determined zone inside the study area, control means controlling the application of said controlled pressure to said zone, then removal of said controlled pressure and image acquisition on said study area exposed to said light, data-processing means using the images acquired to calculate at least one parameter relative to the discoloration and/or the recoloration of said tissue. The compression means calibrated to apply controlled pressure to said zone and retractable to leave said compression zone and/or said study area accessible to said light and/or to the image-acquisition means.

Abstract: A device monitors circumferences of the leg, and estimates volume of a section of the leg, to detect edema, which can be indicative of CHF, and gauge the effectiveness of medication. The device sends the calculations to a database via BLUETOOTH™ for the patient's treating medical personnel to see.

Abstract: This disclosure relates to systems and/or methods for detection of eye blinking using an active contact lens with multiple sensors and detecting orientation of the active contact lens.

Abstract: According to an aspect there is provided an apparatus for determining a measure of the physical fitness of a subject, the apparatus comprising a processing unit that is configured to receive a first measurement signal from a first sensor that measures the force or pressure exerted on an object by the subject over time, the first measurement signal comprising measurements representing the force or pressure exerted on the object during a first movement in which the subject sits down on the object and/or during a second movement in which the subject stands up after sitting on the object; and analyze the first measurement signal to determine the measure of the physical fitness of the subject.

Abstract: A system for analyzing a golf swing is disclosed having an image processor, memory, a main processor, and a camera connected via a communications circuit. A cache of batteries provides power to the image processor, the memory, the main processor, the camera lens, and the communications circuit. An hourglass shaped, two component housing, is provided having a top housing supporting the camera and a bottom housing sized to receive and encapsulate the cache of batteries, said top housing component being operably attached to the bottom housing component such that the top housing component can rotate about a central axis of the bottom housing component and tilt from the central axis.

Abstract: A non-invasive sensing system for measuring the concentration of a substance within an object, the system including a support element adapted to be placed near to, or against, a surface of the object, a first transmitting antenna mounted upon or within the support element for transmitting electromagnetic radiation signals into the object, and a second receiving antenna mounted upon or within the support element, and adjacent to the first transmitting antenna, for receiving at least a portion of the electromagnetic radiation signals that are reflected back to the same surface of the object covered by the support element, due to the transmitted electromagnetic radiation signals having interacted with the substance within the object being measured.

Abstract: Examples of invasive biosensor alignment and retention features and methods are described. One example biosensor includes a housing comprising: a first surface defining a first opening, and a second surface opposite the first surface, the second surface defining a second opening, the first and second openings defining a substantially unobstructed pathway through the housing; a biosensor wire partially disposed within the housing and having an exterior portion extending through the first opening; a hollow insertion needle positioned within the pathway and extending through the first opening, the hollow insertion needle at least partially encircling the biosensor wire; and a biosensor retention feature collapsible against the first surface of the housing, the biosensor retention feature encircling and contacting the hollow insertion needle.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: The present invention is directed to a bio-fluid detector such as a hemoglobin detector having the capability of receiving, storing and transmitting health information utilizing a portable transmitter and receiver including electronic PDAs such as cell phones. Further, the present invention utilizes a non-invasive hemoglobin detector that is connected to a portable transmitter-receiver such as PDAs including, but not limited to, cell phones.

Abstract: A method for noninvasive determination of glucose content in blood. The method includes optically irradiating a biomaterial alternately in any sequence with optical radiation of a first wavelength band of 950-970 nm, optical radiation of a second wavelength band of 1020-1060 nm, optical radiation of a third wavelength band of 930-950 nm, optical radiation of a fourth wavelength band of 740-760 nm and optical radiation of a fifth wavelength band of 830-850 nm, receiving Ron with a receiver the optical radiation diffusely reflected by the biomaterial, converting the received optical radiation into an electric signal and determining the glucose concentration in blood on the basis of the sum of the electric signals received at radiation treatment of the biomaterial with the optical radiation of the second, third and fourth bands which is reduced by values determined by the electric signal received at radiation treatment of the biomaterial with optical radiation of the first and fourth bands.

Abstract: Apparatuses and methods for improving the accuracy of an analyte sensor are disclosed. The sensor may include a photodetector and a low angle sensitive (LAS) optical filter. The photodetector may be configured to convert received light into current indicative of the intensity of the received light. The LAS optical filter may be configured to prevent light having a wavelength outside a band pass region from reaching the photodetector and to pass light having a wavelength within the band pass region to the photodetector. The percentage of light passing through the LAS optical filter may decrease as the angle of incidence of the light increases.

Abstract: A device for measuring brain oxygen level of a subject, including a probe (210) and a detecting means (220), which are respectively coupled to a processor (230). According to the example, the probe (210) includes three light sources (215a, 215b, 215c) that simultaneously emit the first, second, and third NIR wavelengths across the brain of the subject. The first NIR wavelength is the isosbestic wavelength for oxy-hemoglobin (HbO2) and deoxy-hemoglobin (Hb), the second NIR wavelength is shorter than the first NIR wavelength, and the third NIR wavelength is longer than the first NIR wavelength. The detecting means (220) includes a first, second and third detectors (221, 222, 223) for respectively detecting the NIR intensities of the first, second and third NIR wavelengths traveled across the brain. The processor (230) is configured to determine blood oxygen level based on the measured NIR intensities of the first, second and third NIR wavelengths by use of build-in algorithm derived from Beer-Lambert Law.

Abstract: A first medical device can acquire a physiological parameter value from a patient and communicate the physiological parameter value to a medical network interface. The medical network interface can link a patient ID associated with the physiological parameter and a device ID associated with the first medical device with the medical network interface's device ID. The medical network interface can pass the physiological parameter value to a second medical device for further processing or routing to another medical device.

Abstract: Methods and systems for targeting, accessing and diagnosing diseased lung compartments are disclosed. The method comprises introducing a diagnostic catheter with an occluding member at its distal end into a lung segment via an assisted ventilation device; inflating the occluding member to isolate the lung segment; and performing a diagnostic procedure with the catheter while the patient is ventilated. The proximal end of the diagnostic catheter is configured to be attached to a console. The method may also comprise introducing the diagnostic catheter into the lung segment; inflating the occluding member to isolate the lung segment; and monitoring blood oxygen saturation. The method may further comprise introducing the diagnostic catheter into the lung segment; determining tidal flow volume in the lung segment; determining total lung capacity of the patient; and determining a flow rank value based on the tidal flow volume of the lung segment and the total lung capacity.

Abstract: The present invention is directed to an intelligent portable health monitoring apparatus, which is for the purpose of health surveillance. Specifically, the invention of an intelligent portable health monitoring apparatus comprises: a mainboard, and more than one set of photoelectric sensors connecting with the mainboard electronically, the more than one set of photoelectric sensors are able to adjust positions to cover the detected site properly by moving either the photoelectric transmitter or the photoelectric receiver, in order to acquire user's pulse and blood data. With the present invention of an intelligent portable health monitoring apparatus, it solves the problem of errors advantageously, which are induced by the differences of individual users during the noninvasive monitoring process, thus to present the users their accurate health conditions.

Abstract: A laparoscopic medical device includes an oximeter sensor at its tip, which allows the making of oxygen saturation measurements laparoscopically. The device can be a unitary design, wherein a laparoscopic element includes electronics for the oximeter sensor at a distal end (e.g., opposite the tip). The device can be a multiple piece design (e.g., two-piece design), where some electronics is in a separate housing from the laparoscopic element, and the pieces (or portions) are removably connected together. The laparoscopic element can be removed and disposed of; so, the electronics can be reused multiple times with replacement laparoscopic elements. The electronics can include a processing unit for control, computation, or display, or any combination of these. However, in an implementation, the electronics can connect wirelessly to other electronics (e.g., another processing unit) for further control, computation, or display, or any combination of these.

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

Abstract: Disclosed herein are devices, apparatus, systems, methods and kits for collecting and storing a fluid sample from a subject. A device for collecting the fluid sample can include a housing comprising a recess having an opening, a vacuum chamber in the housing and in fluidic communication with the recess, and one or more piercing elements that are extendable through the opening to penetrate skin of the subject. The vacuum chamber can be configured for having a vacuum that draws the skin into the recess. The recess can be configured having a size or shape that enables an increased volume of the fluid sample to be accumulated in the skin drawn into the recess.

Abstract: A method of neurohydrodissection for treating a headache in a patient is disclosed. The method comprises the step of physically inspecting a patient and locating a first compression site of a nerve of the patient where the nerve passes through a tissue and is inflamed. The method comprises the step of ultrasound imaging the patient at the first compression site. The method comprises the step of inserting a syringe at the first compression site, wherein while the first compression site is being imaged, guiding the syringe to an intersection between the nerve and the tissue, injecting a solution with the syringe at the intersection and dissecting the nerve from the tissue. The method comprises the step of confirming with the patient whether a headache symptom has changed.

Abstract: Methods, systems and devices for evaluating the integrity of a uterine cavity. A method comprises introducing transcervically a probe into a patient's uterine cavity, providing a flow of a fluid (e.g., CO2) through the probe into the uterine cavity and monitoring the rate of the flow to characterize the uterine cavity as perforated or non-perforated based on a change in the flow rate.

Abstract: A device for and a method of monitoring the healing status of a fractured bone in a person's limb is disclosed. The external fixation device may include one or more rods or struts that incorporate strain gauges designed to measure the mechanical forces on the strut when force is applied to the fractured bone. The mechanical force data may be collected by an electronic module and transmitted to a computer for statistical analysis. The device may also include a foot insole sensor for measuring the foot plantar force to normalize the data collected by an external fixation device attached to a person's leg. The method of measuring the healing status of a fractured bone includes measuring the changes in mechanical forces exerted on the one or more struts, and based on the measurements, estimating the healing status of the bone.

Abstract: A health status modulator analyzes frequencies emitted by a person to select and implement improvement frequencies at the person. The health status modulator detects frequency information generated at the person, for example a voice sample or a vibrational frequency, and determines which significant frequencies exist within that sample. The modulator could then seek to modify the person's state my implementing alternative frequencies that reinforce detected ideal frequencies, introduce missing ideal frequencies, or counter and eliminate negative frequencies.

Abstract: A wearable device is described. The wearable device comprises: a device body configured to be secured in contact with a subject; a first sensor borne by the device body that is activatable to measure a heart rate of the subject; and control logic configured to activate the first sensor during a monitoring period during which the subject is determined to be in a sleep period.

Abstract: Systems and methods are provided for quantitatively and objectively characterizing sleep architecture in normal individuals and persons with various health conditions. Embodiments of the invention facilitate characterizing temporal-pattern information of an individual's sleep, such as measured by electroencephalography (EEG), for identifying persons with abnormalities in the temporal-pattern information, sequences or durations of their stages of sleeping (“sleep architecture”), for facilitating selecting appropriate therapy or treatment, and for monitoring the effectiveness of such therapy or treatment. In one aspect, a set of time series are formed by electronically representing and storing information pertaining to brain activity, such as EEG hypnogram or sleep information, over a multi-night span.

Abstract: Sunscreen formulations and systems for sun protection and related methods of use are described herein.

Abstract: In-vivo fluid monitoring devices and methods are disclosed herein. An example device is configured for patients which monitors increases and decreases of fluid retention in patients with various clinical conditions such as heart and renal failure pre-operation and post operation thus allowing physicians to more accurately detect said fluid retention gains through a mechanism directly or indirectly connected to circulatory stocking which act as a conduit to detect said fluid changes through skin electrolysis and alterations respective to fluid changes directly corresponding with galvanic skin response measurement changes.

Abstract: Sensors mounted on a textile include at least one of electrically conductive textile electrodes; single or multiple optically coupled infrared and red emitter and photodiode or photo transistor; and thin film or Resistive Temperature Detector (RTD). Textile electrodes, electrical connections, and electrical functionalization use at least one of nanoparticles, nanostructures, and mesostructures. Conductive thread, for electrical connections, may include a fiber core made from conductive materials such as but not limited to metals, alloys, and graphine structures, and a sheath of insulating materials such as but not limited to nylon, polyester, and cotton.

Abstract: Methods, systems, and apparatus for high-resolution patterning of various substrates with functional materials, including nanomaterials. A technique of preparing a patterned substrate in a high-resolution mold for stick and transfer process is disclosed with promotes integrity of the high-resolution pattern onto the substrate. One example of a substrate is an adhesive tape. The transferred pattern(s) are scalable and can be implemented in different fabrication processes. One example is a roll-to-roll processes. In one embodiment, the transferred pattern comprises nanomaterials and the substrate comprises a flexible substrate for use in flexible and conformal assemblies for a wide variety of applications including, but not limited to, electrical-based sensors on non-planar inanimate surfaces, plant body surface, or human or animal skin.

Abstract: Disclosed is a flexible and stretchable electronic device based on a biocompatible film. The biocompatible film is utilized as an encapsulation layer and a substrate layer of the device; a bonding layer is provided between the encapsulation layer and a functional layer; and an adhesion layer is arranged under the substrate layer. The functional layer employs a flexible and stretchable structure. Solution-based transfer printing technology is primarily used during the preparation of such a device to achieve integration of the functional layer and the flexible substrate layer. This device retains and even enhances the flexibility and stretchability structurally. Meanwhile, the biocompatibility properties thereof, such as being waterproof and air permeable, hypoallergenic, etc., allow it to work normally on the human body surface for more than 24 hours without foreign body sensation and discomfort, and thus, skin maceration, redness or other allergic reactions due to poor biocompatibility can be avoided.

Abstract: An electrophysiology catheter is provided. In one embodiment, the catheter includes an elongate, deformable shaft having a proximal end and a distal end and a basket electrode assembly coupled to the distal end of the shaft. The basket electrode assembly has a proximal end and a distal end and is configured to assume a compressed state and an expanded state. The electrode assembly further includes one or more tubular splines having a plurality of electrodes disposed thereon and a plurality of conductors. Each of the plurality of conductors extends through the tubular spline from a corresponding one of the plurality of electrodes to the proximal end of the basket electrode assembly. The tubular splines are configured to assume a non-planar (e.g., a twisted or helical) shape in the expanded state.