Abstract: This invention relates to molecular diagnostics and, more specifically DNA-based tests for the prognosis and/or monitoring of fibrotic disease progression in humans, and processes for stratifying patients based on their likely rates of fibrotic disease progression. The invention also relates to the field of therapy for fibrotic disease, based on such prognoses, monitoring and stratification results, such as in monitoring and/or stratifying and/or treating patients having a higher likelihood of rapid fibrotic disease progression.

Abstract: A sub-dermal structure visualization system and method is disclosed. The system may use an illumination module including: a near-infrared (NIR) light source adapted to substantially uniformly illuminate an imaged area including sub-dermal regions thereof with NIR light; and a first optical system including at least one optical element for controlling at least one of spectral and polarization properties of the NIR light prior to illuminating the imaged area. An imaging module rejects unwanted signals from an imaged area while passing desired optical signals that are to be received by an image acquisition module. The desired optical signals can comprise a vein visualization signal to assist in visualizing a vascular structure below a skin layer of a patient.

Abstract: A patient worn sensor assembly for detecting, recording, and communicating patient vital signs includes several structural features that can provide increased signal quality, reduction in signal noise, increased patient comfort, increased reliability, and increased adhesion to a patient's skin. The patient worn sensor can track vital sign information such as blood pressure, body temperature, respiratory rate, blood oxygenation, heart rhythm (via ECG), heart rate, blood glucose level, and hydration (bio-impedance) levels. The sensor can also track and record additional information about patients, including patient movement, activity, and sleep patterns.

Abstract: A catheter adapted for greater mapping resolution and location precision has a basket-shaped, high density electrode assembly for large-area mapping, and an integrated distal tip providing an array of ultra-high density microelectrodes for acute focal mapping. The basket-shaped electrode assembly 18 has a plurality of electrode-carrying spines and the distal tip has a nonmetallic, electrically insulating substrate body with indentations in which microelectrodes are positioned in a manner that the outer surface is generally flush with the outer surface of the substrate body to present a generally smooth, atraumatic distal tip profile.

Abstract: A first node of a patient care device processes data relating to the patient care device and sets a public variable equal to a value of the data. A second node receives the public variable from the first node, sets a private variable equal to the value of the public variable, and executes a software program that reads the private variable but not the public variable. In other embodiments, the second node checks to see if the public variable is registered at the second node, and if so, uses the private variable in carrying out a function. The first node executes a first software program that sets the public variable to the value and relies on a service to share the value with the second node. The sharing occurs despite the first software program not containing any instructions for transmitting the value or variable to the second node.

Abstract: Certain aspects of the present disclosure relate to a wearable system including one or more wearable acquisition devices. Each acquisition device includes a sensor to capture samples of a biomedical signal and circuitry to process the samples for transmission to a mobile device. The samples are encoded for transmission and decoded at the mobile device to reconstruct the biomedical signal and, based on the reconstructed biomedical signal, provide output through a user interface of the mobile device. The wearable system includes at least an acquisition device for capturing an electro-cardiogram signal (ECG). Other biomedical signals, such as a photoplethysmograph (PPG) signal, may also be captured. The wearable system may comprise a Body Area Network (BAN).

Abstract: An automatic classification method for distinguishing between indolent and clinically significant carcinoma using multiparametric MRI (mp-MRI) imaging is provided. By utilizing a convolutional neural network (CNN), which automatically extracts deep features, the hierarchical classification framework avoids deficiencies in current schemes in the art such as the need to provide handcrafted features predefined by a domain expert and the precise delineation of lesion boundaries by a human or computerized algorithm. This hierarchical classification framework is trained using previously acquired mp-MRI data with known cancer classification characteristics and the framework is applied to mp-MRI images of new patients to provide identification and computerized cancer classification results of a suspicious lesion.

Abstract: A method of real peak detection includes optimizing a scoring function using training signals with known peaks and known features. The method includes receiving an input signal measured from a mobile sensor and representative of a cyclic biological process. The method includes filtering the input signal to remove low and high frequency noise. The method includes identifying candidate peaks and troughs within a selected time range of the input signal. The method includes extracting a feature that describes properties of the two or more candidate peaks. The method includes scoring the candidate peaks using the scoring function, selecting a real peak as the candidate peak with the highest score, and generating a biologic interval data set with the real peak and another peak that is representative of health markers. The method includes assessing a condition of the patient based on the biologic interval data set.

Abstract: A magnetic resonance (MR) system (10) for guidance of a shaft or needle (16) to a target (14) of a subject (12) is provided. The system includes a user interface (76). The user interface (76) includes a frame (78) positioned on a surface of the subject (12). The frame (78) includes an opening (82) over an entry point of a planned trajectory for the shaft or needle (16). The planned trajectory extends from the entry point to the target (14). The user interface (76) further includes one or more visual indicators (80) arranged on the frame (78) around the opening (82). The one or more visual indicators (80) at least one of: 1) visually indicate deviation of the shaft or needle (16) from the planned trajectory; and 2) visually indicate a current position of a real-time slice of real-time MR images.

Abstract: A robust alarm system has an alarm controller adapted to input an alarm trigger and to generate at least one alarm drive signal in response. Alarm subsystems input the alarm drive signal and activate one or more of multiple alarms accordingly. A subsystem function signal provides feedback to the alarm controller as to alarm subsystem integrity. A malfunction indicator is output from the alarm controller in response to a failure within the alarm subsystems.

Abstract: An overdose of opioids can cause the user to stop breathing, resulting in death. A physiological monitoring system monitors respiration based on oxygen saturation readings from a fingertip pulse oximeter in communication with a smart mobile device and sends opioid monitoring information from the smart mobile device to an opioid overdose monitoring service. The opioid overdose monitoring service notifies a first set of contacts when the opioid monitoring information.

Abstract: An X-ray CT apparatus according to an embodiment includes setting circuitry. The setting circuitry is configured to set a third plan for a patient, by integrating together a first plan for the patient and a second plan for the patient.

Abstract: An X-ray fluoroscopic imaging apparatus includes a table, an imaging system including an X-ray source and a detector, and an operation panel unit including a plurality of operation input units. The plurality of operation input units include an emergency stop unit and a stop state release unit. The emergency stop unit and the stop state release unit are provided separately from each other at different positions.

Abstract: The present invention relates to a guidance device (10) for a TEE probe (20), a medical imaging system (1), a method for guiding a TEE probe (20), a computer program element for controlling such device and a computer readable medium having stored such computer program element. The guidance device (10) for a TEE probe (20) comprises an image data provision unit (11), and a processing unit (12). The image data provision unit (11) is configured to provide first image data showing an interventional device (40) and a TEE probe (20) in an initial position and orientation. The processing unit (12) is configured to determine a centerline of the interventional device (40) in the first image data. The processing unit (12) is configured to determine a plane (41) orthogonal to a tangent of the centerline as viewing plane. The processing unit (12) is configured to calculate an imaging plane and an imaging orientation of the TEE probe (20) to lie approximately in the viewing plane.

Abstract: Dental radiographic imaging systems and/or methods for using the same can provide panoramic 2D dental radiographic images. Providing improved panoramic 2D image quality can depend on imaging a desired/selected focal trough, which is itself based on a correct positioning of the patient's head inside the panoramic dental imaging system. Exemplary dental radiographic imaging systems and/or methods for using the same can provide a patient positioning device (e.g., bite stick embodiments) that can position or urge patients to get the right positioning (such as head tilt) to increase probabilities of the improved/best panoramic image reconstruction. Further, certain exemplary bite stick embodiments can repeatedly, consistently and/or correctly position patient after patient for panoramic imaging.

Abstract: The present disclosure relates to a lifting apparatus. The lifting apparatus may include a base column, a mobile column, a sliding component, a supporting arm, a lifting system, and a move-coordination system. The mobile column connected to the base column may be vertically movable relative to the base column. The lifting system may be configured to cause the movement of the mobile column. The sliding component connected to the mobile column may be vertically movable relative to the mobile column. The mobile column and the sliding component may be connected via the move-coordination system, which enables the sliding component and the mobile column to move simultaneously according to a predetermined relative motion relationship. The supporting arm may be connected to the sliding component.

Abstract: A radiation emitting device includes a radiation source unit that irradiates a subject with radiation, a camera that captures an image of the subject to acquire a captured image of the subject, and a monitor that displays the captured image. A control device controls at least one of the inclination or the rotation angle of the monitor on the basis of at least one of the direction of the radiation source unit, the inclination of a radiation detector, and the rotation angle of the radiation detector, or the display content of the monitor.

Abstract: The present invention relates to visualizing vascular structures. In order to provide further improved digital subtraction angiography, a device (10) for visualizing vascular structures is provided that comprises a data provision unit (12), a data processing module (14), and an output unit (16). The data provision unit is configured to provide a first sequence of non-contrast X-ray images of a region of interest of a patient for use as raw X-ray mask images. The data provision unit is also configured to provide a second sequence of contrast X-ray images of the region of interest of a patient for use as raw X-ray live-images. The processing unit is configured to perform a first spatial subtraction for the first sequence of non-contrast X-ray images resulting in a first sequence of spatial-subtracted mask images. The processing unit is also configured to perform a second spatial subtraction for the second sequence of contrast X-ray images resulting in a second sequence of spatial-subtracted X-ray live-images.

Abstract: A radiation imaging apparatus is provided that includes: a radiation detection unit arranged to detect radiation; a generation unit configured to generate a radiation image based on the detected radiation; a storage configured to store a plurality of radiation images; a detection unit configured to detect one of a failure in and impossibility of one of taking of the radiation image and storing of the radiation image in the storage; and a communication unit configured to establish communication with an external apparatus when one of the failure and the impossibility is detected.

Abstract: A system and method of x-ray imaging includes obtaining a plurality of x-ray projection images of a patient. At least one object in the plurality of x-ray projection images is identified. A priori information of the identified at least one object is obtained. A three dimensional volume is reconstructed from the plurality of x-ray projection images. The a priori information is used to refine the acquisition of x-ray projection images or presentation of the three dimensional volume.

Abstract: A radiation irradiating apparatus includes a radiation generator that generates radiation and a switch that controls emission of the radiation from the radiation generator. The radiation generator and the switch are constituted by separate housings. The radiation generator and the switch are attachable and detachable to and from each other via a surface of a portion of each of the housings thereof.

Abstract: A fluoroscopic surgical system employing a FORS sensor (40), a navigation controller (70), a fluoroscopic imager (30) and a mechanical connector (50) adjoined to the fluoroscopic imager (30). In operation, mechanical connector (50) is utilized to detachably attach FORS senor to fluoroscopic imager (30), whereby navigation controller (70) processes a shape reconstruction of FORS sensor (40) relative to a reference point fixed or movable within an operating space (20) for controlling a tracking of fluoroscopic imager (30) within the operating space (20). The system may further employ a surgical instrument (60) whereby, concurrently or subsequently to a fluoroscopic imaging of a patient anatomy, FORS sensor (40) is thereafter detached from fluoroscopic imager (30) and detachably attached to surgical instrument (60), or FORS sensor (40) is concurrently detachably attached to fluoroscopic imager (30) and surgical instrument (60).

Abstract: A radiographic imaging system includes an irradiating apparatus, a first clock, a radiographic imaging apparatus, a second clock and a hardware processor. The irradiating apparatus generates radiation. The first clock keeps time and works with the irradiating apparatus. The radiographic imaging apparatus generates image data based on received radiation. The second clock keeps time and works with the radiographic imaging apparatus. The hardware processor (i) obtains a clock value of the first clock at a predetermined time point and a clock value of the second clock at the predetermined time point respectively as first clock information and second clock information, (ii) makes a determination as to whether a specific condition is met based on the obtained first clock information and the obtained second clock information, and (iii) in response to the specific condition being met, performs a specific output.

Abstract: A phantom, phantom system, and method of phantom identification include a first material that forms a phantom. A phantom identifier includes at least one unit marker. The at least one unit marker identifies a physical characteristic of the phantom. In a method of phantom identification, an image of the phantom is obtained that includes the phantom identifier. The at least one unit marker is identified, the at least one unit marker encodes a value representative of a physical characteristic of the phantom.

Abstract: There are disclosed a collimator, a radiation emitting assembly and an inspection apparatus. The collimator is configured to collimate radiation from a radiation emitter. One of the collimator and the radiation emitter is provided with a protrusion portion and the other is provided with a recess portion such that the protrusion portion is capable of being placed within the recess portion and the radiation emitter and the collimator are allowed to be arranged close to and connected with each other, and that the radiation passes through passages in the protrusion portion and the recess portion from the radiation emitter to the collimator.

Abstract: A Doppler fetal heartbeat monitor includes: a housing; a mainboard; a loudspeaker installed in the housing and electrically connected to the mainboard; and an ultrasonic transducer installed in the housing, electrically connected to the mainboard, and comprising at least one transduction wafer configured to generate an impulse wave, in which the ultrasonic transducer is internally provided at a head end of the housing, and the loudspeaker and the mainboard are internally provided at a tail end of the housing. By arranging the loudspeaker, the mainboard and the ultrasonic transducer in the housing, the Doppler fetal heartbeat monitor can have a compact structure and a small volume. Moreover, it is possible to reduce positive feedback of a sound system and a probability of a self-excited whistle.

Abstract: Ultrasound-based acoustic streaming for deciding whether material is fluid is dependent upon any one or more of a variety of criteria. Examples are displacement, speed, temporal or spatial flow variance, progressive decorrelation, slope or straightness of accumulated signal to background comparisons over time, and relative displacement to adjacent soft tissue. Echogenicity-based area identification is combinable with the above movement characteristic detection in the deciding. Fluid pool identification is performable from the area-limited acoustic streaming testing and ultrasound attenuation readings. Candidates from among the areas are screenable based on specific shapes or bodily organs detected. Natural flow can be excluded from streaming detection by identification of blood vessels. Processing for each FAST ultrasound view, or for the entire procedure, is performable automatically, without need for user intervention or with user intervention to identify suspected areas.

Abstract: The present invention relates to a method for providing three-dimensional ultrasound images of a volume (50) and an ultrasound imaging system (10). In particular, the current invention applies to live three-dimensional imaging. To maintain a steady frame rate of the displayed images even if a user changes a region of interest and, therewith, the size of the volume (50) to be scanned, it is contemplated to adjust a density of the scanning lines within the volume (50) as a function of a size of the volume while maintaining a total number of scanning lines across the volume (50).

Abstract: Battery-powered ultrasound scanner for veterinary applications, and operating method. Ultrasound measurements are processed to determine if an ultrasound probe is not being moved and, if it is not being moved, the average rate at which ultrasound pulses is generated, thereby reducing power consumption. The average rate at which ultrasound pulses are generated is reduced step-wise if non-movement persist but increase rapidly when movement recommences.

Abstract: An adhesive deliver apparatus includes: a separable holder having a flexible press region thereon and comprising an interior receiving chamber for placing the adhesive tube; a support tube having a substantially elongated shape and comprising a proximal end and a distal end; a connector connected with the proximal end of the support tube and arranged to operably connect with a nozzle of the adhesive tube; and an inner tube positioned within the support tube and comprising an inlet end connected with the connector and an outlet end approximating to the distal end of the support tube; wherein when the press region is pressed to cause an interior surface of the press region to press the adhesive tube, the adhesive fluid will be squeezed out from the adhesive tube and transmitted through the inner tube from the inlet end to the outlet end.

Abstract: A vascular closure system is configured to seal an incision in a vessel of the patient's body. The system includes a slider that is moved from an initial position to a deployed position (that is, towards the puncture of the patient body), until the proximal end of the slider exposes a reference marker on an inner tube. This confirms the deployment of the closure element and completely expands or opens or pivots the closure element in the blood vessel.

Abstract: An illuminated medical device, comprising a blade portion having a proximal end and a distal end, the blade portion comprising an operative portion at the distal end, a handle portion connected to the proximal end of the blade portion, the handle portion having a hollow cross-section and an open bottom end, an illumination assembly comprising at least one light source, an activation device for energizing the light source, and at least one battery for powering the light source, and an end cap assembly coupled to the open bottom end of the handle portion and accommodating the activation device and the at least one battery therein. In the illuminated medical device, a portion of the activation device extends through an opening in the end cap assembly and the at least one battery is held by the end cap assembly to overlap with the activation device and the opening in the end cap assembly.

Abstract: A suture anchor includes a material having thermoplastic properties and is fixated in a hard tissue opening by liquefying at least part of this material and letting it penetrate into walls of the hard tissue opening. During the named fixation and preferably towards the end of it, the suture being held in a distal suture conduit is locked relative to the hard tissue by being clamped between the suture anchor and the wall of the hard tissue opening or by being clamped or braked through collapse of the suture conduit.

Abstract: An anchorage device includes a substrate extending along a longitudinal axis between a first end having a first bonding area and an opposite second end having a second bonding area. The substrate has a third bonding area between the first and second bonding areas. Kits, systems and methods are disclosed.

Abstract: Methods and devices are provided for attaching soft tissue to bone. In general, a deployment device, insertion assembly, and suture anchor are provided. The insertion assembly is coupled between the deployment device and the suture anchor to allow the deployment device to deploy the suture anchor into bone. Each of the various components disclosed herein can be used alone, in combination with one another, or in combination with various other devices.

Abstract: An anvil assembly suitable for trans-oral delivery includes an anvil head configured to receive a suture that secures the anvil head in a delivery position and is separable from the anvil head following delivery of the anvil assembly. An anvil delivery assembly includes the anvil assembly, a delivery assembly secured to the anvil assembly, and a suture selectively secured to the anvil assembly for securing the anvil assembly in a delivery position and retrieving the anvil assembly.

Abstract: A rotation adapter for a minimally invasive surgical apparatus is disclosed. The rotation adapter has a proximal journal and a distal journal. The rotation adapter also has a rotation index coupled between the proximal and distal journals. The rotation adapter further has an actuator input and an effector output. A rotation adapter receiver for a minimally invasive surgical apparatus is also disclosed. The rotation adapter receiver has opposing beams and a proximal bushing coupled between the opposing beams. The rotation adapter receiver also has a distal bushing coupled between the opposing beams. The rotation adapter receiver further has a rotation constraint coupled between the opposing beams and positioned between the proximal and distal bushings.

Abstract: A device for deploying a suture clip onto a suture can include a proximal handle portion that includes an actuation mechanism. The device can also include an outer shaft defining an inner lumen. A crimping assembly can be at least partially disposed within a distal end of the outer shaft. The crimping assembly can include a plurality of crimping members configured to receive and radially compress a suture clip. The actuating mechanism can be configured to move the plurality of crimping members radially inwardly from a first position, where the crimping members are configured to receive a suture clip, to a second position where the plurality of crimping members are configured to radially compress the suture clip, causing the suture clip to plastically deform and become secured around one or more sutures.

Abstract: The present invention includes a suture article and a suture placement device adapted to insert into opposing tissue surfaces the anchors of a suture article having anchors on its terminal ends, the device comprising in general terms: (a) an optional handle portion; (b) an insertion portion extending from the handle having a distal end comprising anchor-directing portions that diverge from one another so as to form a V-shape, adapted to releasably engage the anchors; and (c) a hollow cinching cannula/suture conduit slidingly engaged by the handle portion so as to be moveable between a position relatively nearer the handle and a position relatively nearer the insertion portion distal end.

Abstract: The present invention provides novel medical devices for use in surgical procedures and methods for manufacturing novel medical devices. In some embodiments, the novel medical devices can include surgical needles that are capable of being repeatedly passed through tissue using minimal force. More particularly, the surgical needles can be manufactured with one or more coatings that provide the surgical needles with both durability and lubricity for ease of repeated and successive passes through tissue. Novel methods for manufacturing the surgical needles and for providing and applying coatings to the surgical needles are also provided.

Abstract: A method and apparatus are disclosed for loading a closing device onto a delivery device at the point of use and for using the apparatus for treating the intervertebral disc. The apparatus includes a cartridge for loading a closing device onto a delivery device at the point of use, the cartridge comprising a tab holding feature for holding one or more tabs of the closing device and a tab loading feature for loading tabs onto the delivery device. A method of treating an intervertebral disc includes the steps of loading a closing device into a delivery device at the point of use, the closing device comprising at least two tabs coupled to a connecting element, and substantially approximating a defect in the intervertebral disc using the closing device delivered by the delivery device.

Abstract: A surgical suturing device has an elongate shaft has a proximal end, a distal end, and a longitudinal axis between the proximal and distal ends. An actuator is connected to the proximal end of the elongate shaft. A circular needle applier is on the distal end of the elongate shaft. The circular needle applier has an arced needle and a needle driver operatively connected to the actuator to rotate the arced needle in a circular path. A joint is positioned between the proximal and distal ends of the elongate shaft. The joint is operatively connected to the actuator to selectively articulate the shaft. A bearing is on the shaft positioned distally of the joint. The bearing is operatively connected to the actuator to selectively rotate the circular needle applier about the longitudinal axis.

Abstract: The present disclosure relates to a surgical stapling instrument comprising a handle assembly, an elongated body portion extending from the handle assembly, and an end effector supported on a distal portion of the elongated body portion. The end effector includes a curved housing having a base portion and a jaw portion, a curved anvil assembly supported on the jaw portion, and a curved cartridge assembly supported on the base portion. The cartridge assembly defining first and second arrays of staples receiving slots, the first array of staple receiving slots includes three rows of staples and the second array of staple receiving slots includes two rows of staples. A height of the staples in each of the rows of three rows of staples of the first array of staple receiving slots is different.

Abstract: Methods and devices are provided for promoting wound healing. In general, surgical staplers and stapler components are provided having a coating thereon that is configured to selectively control an interaction between at least one matrix metalloproteinase (MMP) inhibitor and an outer surface of the stapler or stapler component.

Abstract: Systems, apparatus, and methods related to wound closure devices comprising one or more microstructures are described herein. In some embodiments, the wound closure devices include a backing and a microstructure array. The microstructure array may include a first portion, a second portion, and a bridge portion. The first portion and the second portion each include one or more microstructures configured to penetrate tissue. Additionally, the first portion and the second portion each include one or more expandable portions such that the wound closure device is configured to expand in length. The wound closure device is configured to grip tissue surrounding a wound to either close the wound or secure the tissue in place.

Abstract: An anastomotic coupler is provided. A ring forms an aperture operable to receive a tubular structure. The ring can include a plurality of receiving portions. A fixation device includes a housing and a cartridge. The cartridge includes a plurality of fasteners, and the housing is operable to receive the tubular structure such that the cartridge is inserted into a lumen of the tubular structure. The ring is aligned with the cartridge such that the receiving portions are aligned with the fasteners. Upon actuation of the fixation device, the fasteners puncture the tubular structure radially outward from the lumen and are received by the receiving portions such that the tubular structure is coupled with the ring.

Abstract: Devices and methods for treatment of a patient's vasculature are described. The device includes a self-expanding resilient permeable shell having a radially constrained state and an expanded state with a globular, axially shortened configuration. The permeable shell may be a single layer of braided elongate filaments having first and second ends that are secured at the proximal end of the permeable shell. The devices may also include permeable shells made of woven braided mesh having a variable mesh density, i.e., the average size of pores in one region are a different than the average size of pores in another region. Methods of using the device to treat a cerebral aneurysm are also described. Methods of forming a tubular braid are also described. Methods of forming a tubular braid with variable braid densities are described. Methods of forming a tubular braid using a castellated mandrel are also described.

Abstract: The present disclosure relates to a braid for treating an aneurysm. The braid can include a distal end opposite a proximal end. Translating the braid can cause the delivery portion to expand and form a distal sack as well as invert into itself.

Abstract: Devices and methods for treating vascular defects, such as, for example, balloon-type aneurysms, are described herein. In one embodiment, an apparatus includes an insertion portion and an expandable implant. The expandable implant is configured to be deployed in an aneurysm and is coupled to the insertion portion. The expandable implant has a first portion and a second portion coupled to the first portion. The expandable implant is movable between a first configuration in which the first portion and the second portion are substantially linearly aligned and a second configuration in which the second portion at least partially overlaps the first portion.

Abstract: A method of treating an aneurysm with an occlusion device having an inner embolic device with a proximal section and a distal section. The distal section has a first stiffness and the proximal section has a second stiffness. Further, the device has an expandable mesh capable of a collapsed position and an expanded position. The mesh can be disposed over, and attached to, a portion of the proximal section of the inner embolic device. The first stiffness is greater than the second stiffness and the inner embolic device comprises a preselected shape which assists in transforming the expandable mesh from the collapsed position to the expanded position.