Abstract: In an ophthalmological device, a memory stores a three dimensional data set acquired by applying OCT to a subject's eye. A fourth color coding unit assigns color information according to a depth position to the three dimensional data set. A fourth layer region identifying unit identifies layer regions by applying segmentation to the three dimensional data set, A fourth blood vessel region extracting unit extracts a blood vessel region from each of the layer regions identified. A fourth front image constructing unit constructs a front image based on each of the blood vessel regions extracted. A fourth image composing unit composes at least two of the front images constructed based on the color information, to construct a composite front image.

Abstract: Systems and methods for initializing and calibrating an eye tracking system include an eye tracker configured to capture a first image of an eye from a first location and a second image of the eye from a second location, and a control processor configured to detect a first plurality of eye characteristics from the first image, the eye characteristics having first corresponding image coordinates, detect a second plurality of eye characteristics from the second image, the eye characteristics having second corresponding image coordinates, and determine a calibration offset and a calibration gain. The control processor may be further configured to determine an eye fixation position and orientation relative to an optical axis of the eye tracker based at least in part on the first corresponding image coordinates and/or the second corresponding image coordinates.

Abstract: Systems and methods for tracking the position and condition of an eye during an ophthalmic procedure include an ophthalmic device configured to measure characteristics of an eye, an eye tracker configured to capture a stream of eye images, and a logic device configured to analyze the stream of images to determine whether the eye is fixating on a target object, detect a predetermined blink sequence in the first stream of images, delay for a predetermined tear stabilization period, start a stable tear film interval, and during the stable tear film interval, capture at least one measurement of the eye using the ophthalmic device when the eye is fixating. The blink sequence may include a plurality of blinks in succession and the detection of the blink sequence may include processing the images through a neural network trained to detect an open eye and/or a closed eye.

Abstract: The ophthalmic optical system is configured to apply an angular scanning light ray to an eye. M=|?out/?in| is defined, where ?in represents an angle between an incident light ray to the ophthalmic optical system and an optical axis of the ophthalmic optical system, and ?out represents an angle between an exiting light ray exiting from the ophthalmic optical system toward the eye and the optical axis. The ophthalmic optical system satisfies a conditional expression Mpar<Mmax, where Mpar represents M in a case that the incident light ray is a paraxial ray, Mmax represents M in a case that the incident light ray is a ray of a maximum angle of win.

Abstract: An ophthalmic device for imaging an eye, wherein a scanning element scans a first portion of light beam across a region of an eye via a light guiding component and a second portion of the light beam is reflected back by the light guiding component. The ophthalmic device further comprises: a light detector to detect light reflected from eye and guided to the light detector by the light guiding component; and a dynamic amplitude mask which receives the light reflected from the eye and the light reflected back by the light guiding component, and has an unmasked portion to allow light reflected from the eye to reach the light detector, and a masked portion whose spatial distribution varies with a scan angle such that the masked portion prevents light reflected back by the light guiding component from reaching the light detector during the scan.

Abstract: The invention provides devices and methods for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject. Embodiments include a lens that is adapted to fit on the subject's eye, a microstructure disposed in or on the lens, the microstructure having at least one feature that exhibits a change in shape and/or geometry and/or position on the lens in response to a change in curvature of the lens. When the curvature of the lens changes in response to a change in IOP, a corresponding change in shape and/or geometry and/or position of the feature may be used to determine the change in IOP. The change in the feature is detectable in digital images of the lens taken with a mobile electronic device such as a smartphone.

Abstract: Systems and methods are provided for obtaining sight screenings, optical prescriptions and fittings for eyeglasses and contact lenses. A system can be self-operated through a voice-activated response system that enables an individual to determine one's own refraction, or can be operated with the assistance of a technician. A plurality of customer diagnostic locations can include digital equipment and optical instruments to conduct the sight screening. The data generated at these locations can be transferred to a remotely located eye doctor who interacts with a customer via a live audio-video connection to assist with interpreting the data, diagnosing the customer and operating the instruments at the locations. The eye doctor diagnoses, consults and authorizes the prescriptions for the customer. The customer's data can be sent to a lens laboratory to enable the fabrication, purchasing, and delivery of eyeglasses or contact lenses.

Abstract: Disclosed is an electronic device comprising: a biometric sensor, including at least one light emitting diode (LED) and at least one light receiving unit, for acquiring biometric information by means of the at least one light emitting device and the at least one light receiving unit; a power receiving circuit configured to receive a wireless power signal from an external electronic device; and a processor operatively coupled to the biometric sensor and the power receiving circuit. The processor may be configured to receive a designated wireless power signal from the external electronic device by using the power receiving circuit and to perform optical communication with the external electronic device by using the biosensor when the designated wireless power signal is received. Other various embodiments identified from the specification are also possible.

Abstract: A diagnostic method for determining if a patient is viable candidate for a surgical procedure to permanently eliminate migraine headache pain. The method includes determining if a patient's pain is a migraine pain condition or pain from another medical condition and determining an anatomical location of the determined migraine pain condition. Once the anatomical location is determined, the method correlates the determined anatomical location of the migraine pain condition to a root cause nasal/sinus location and determines a root cause nasal/sinus condition that is causing the patient's migraine pain. Once these diagnostic procedures are complete, the patient may be scheduled for surgery to eliminate the root cause nasal/sinus condition, and thus, permanently eliminate the migraine headache pain.

Abstract: In alternative embodiments, provided are methods and products of manufacture for photoacoustic imaging of the periodontium of individuals in need thereof for noninvasive periodontal probing depth measurements and periodontal pocket imaging and gingival thickness. In alternative embodiments, products of manufacture as provided herein can observe or measure soft tissue contrast, e.g., gums, the periodontium, or the oral mucosa can be imaged and/or measured.

Abstract: Systems and methods are provided for preparation of orthodontics and prosthodontics. A method may include scanning a patient's teeth to form first 3D data of the patient's teeth including a removable element that obscures part of the dental surfaces of the patient's teeth and non-obscured tooth surfaces, removing the removable element form the patient's teeth so that the removable element no longer obscures the part of the dental surfaces of the patient's teeth, and scanning the previously obscured part of the dental surfaces of the patent's teeth and the non-obscured tooth surfaces.

Abstract: A method for determining a material type of an object of interest comprises: directing, using a radio frequency (RF) source, RF energy into a region of interest, the region of interest comprising the object of interest, a known reference and a boundary between the object of interest and the known reference; detecting, using an acoustic receiver, at least one thermoacoustic multi-polar signal generated in response to the RF energy; correlating, by one or more processors, the at least one thermoacoustic multi-polar signal to a transmitted power correction factor to generate a corrected thermoacoustic multi-polar signal; and determining, by the one or more processors, the material type of the object of interest as a function of the corrected thermoacoustic multi-polar signal and a transmitted power of the RF energy.

Abstract: A computer-implemented method for determining a heart rate and respiratory rate from a radio frequency signal comprises inputting a radio frequency signal obtained from a test subject into a neural network. The method further comprises training the neural network using the radio frequency signal and extracting a heart rate and a respiratory rate from the radio frequency signal using the neural network. Further, the method comprises comparing the heart rate and the respiratory rate extracted from the radio frequency signal to a verifiable heart rate and verifiable respiratory rate for the test subject to compute an error measure. Finally, the method comprises using the error measure to apply back propagation to adjust front end parameters for one or more layers of the neural networks to improve a prediction accuracy of the neural network.

Abstract: A method and apparatus for hemodynamically characterizing a neurological or fitness state by dynamic scattering light (DLS) is disclosed herein. In particular, a non-pulsatile blood-shear-rate-descriptive (BSRD) signal(s) is optically generated and analyzed. In some embodiments, the BSRD signal is generated dynamically so as to adaptively maximize (i.e. according to a bandpass or frequency-selection profile) a prominence of a predetermined non-pulsatile physiological signal within the BSRD. In some embodiments, the BSRD is subjected to a stochastic or stationary-status analysis. Alternatively or additionally, the neurological or fitness state may be computed from multiple BSRDs, including two or more of: (i) a [sub-200 Hz, ˜300 Hz] BSRD signal; (ii) a [˜300 Hz, ˜1000 Hz] signal; (iii) a [˜1000 Hz, ˜4000 Hz] signal and (iv) a [4000 Hz, z Hz] (z>=7,000) signal.

Abstract: A real-time sensing measurement apparatus for a respiratory volume of a tested person includes a controller, a pulse measuring device, a temperature sensor, a flow rate sensor and a storage module. The controller receives an electric signal transmitted by the pulse measuring device, the temperature sensor and the flow rate sensor. The controller, the pulse measuring device, the temperature sensor, the flow rate sensor and the storage module communicate through electric signals. The pulse measuring device, the temperature sensor and the flow rate sensor monitor the respiratory volume of the tested person in real time to obtain test data by the storage module. The different states of the user can be measured in real time by the pulse measuring device, the temperature sensor and the flow rate sensor, and measurement results are rectified in various aspects.

Abstract: A blood and cardiovascular condition determination apparatus is provided. The blood and cardiovascular condition determination apparatus may include a first pulse wave signal sensor, a second pulse wave signal and a processing unit. The first pulse wave signal sensor may be configured to generate a first pulse wave signal associated with a first section of a living body. The second pulse wave signal sensor may be configured to generate a second pulse wave signal associated with a second section of the living body. The processing unit may determine at least one blood and cardiovascular condition based on the first pulse wave signal and the second pulse wave signal. The at least one blood and cardiovascular condition may include at least one of a blood pressure, a blood sugar level, a blood oxygen level, a blood vessel aging level, or a blood viscosity.

Abstract: The invention includes monitoring the perfusion of a tissue of an organ using a device having a perfusion sensor to detect a perfusion of the tissue, and at least one activity sensor to detect a muscle activity of the organ. The at least one activity sensor is arranged in proximity to the perfusion sensor. Both sensors are linked to a processing unit. The processing unit receives, as input, perfusion measurement data and muscle activity data, and allows the muscle activity data to be taken into account for monitoring the perfusion of the tissue. The perfusion measurement data are invalidated during the muscle activity periods.

Abstract: Devices, systems, and methods for visually depicting a vessel and evaluating treatment options are disclosed. The methods can include introducing instruments into the vessel of a patient and obtaining proximal and distal pressure measurements of a stenosis of the vessel, calculating a pressure ratio based on the obtained proximal and distal pressure measurements, applying a correlation factor to the calculated pressure ratio to produce a predicted diagnostic pressure ratio, and displaying the predicted diagnostic pressure ratio to a user.

Abstract: The present invention provides a wearable device for monitoring blood-pressure.

Abstract: A system and method for determining cardiovascular parameters can include: receiving a plethymogram (PG) dataset, removing noise from the PG dataset, segmenting the PG dataset, extracting a set of fiducials from the PG dataset, and transforming the set of fiducials to determine the cardiovascular parameters.

Abstract: A cardiovascular monitoring apparatus, the apparatus comprising: a photoplethysmography (PPG) sensor (510), having at least one light emitting element (310) and at least one light sensing element (320), for obtaining at least one PPG signal from a patient; and a controller comprising: a determination module (550) for determining whether a signal obtained by a particular light sensing element is suitable for deriving information relevant to a patient's cardiovascular system; and a processing module (540) for processing a signal that is determined to be suitable for deriving information relevant to the patient's cardiovascular system to derive information relevant to the patient's cardiovascular system.

Abstract: A portable multi-lead electrocardiogram device includes a holding case, a signal processing module and three metal contacts. The signal processing module is located in the holding case. The metal contacts are located on an exterior surface of the holding case and are electrically connected to the signal processing module. The metal contacts are respectively a body contact, a left hand contact and a right hand contact. The device can measure the electrical activities of the heart beat from two different directions, which greatly improves detecting capability. Professional 12-lead electrocardiogram can also be performed by multiple times of measuring. This portable device allows patients with history of myocardial infarction to perform electrocardiogram test timely when feeling ill and to seek medical attention early.

Abstract: Bioinformation of a seated person is more accurately measured. A heartbeat measurement device for measuring heartbeat of a person seated on a vehicle seat has heartbeat sensors and a circuit substrate: the heartbeat sensors have leading wires which output electric signals corresponding to a heartbeat and constitute a transmission path for the electric signals; and the circuit substrate has input terminals which receives the electric signals output from the heartbeat sensors, and a differential amplifier which amplifies the electric signals input to the input terminals. The heartbeat sensors and the circuit substrate are disposed in positions adjacent to each other in the vehicle seat, and terminal portions of the leading wires come out from portions adjacent to the circuit board of the heartbeat sensors are connected to the input terminals in a state abutting the input terminals.

Abstract: A connection device for a deflectable medical device, such as a catheter, comprises an elongate planarity wire having a proximal end and a distal end, an elongate activation wire having a proximal end a distal end, a passage and an interface. The passage extends through the planarity wire near the distal end of the planarity wire. The distal end of the activation wire extends through the passage. The interface is between the passage and the activation wire, and may comprise one or more of the following: a hook and bore interface, a detent interface, a mechanical interface, or a metallurgical interface.

Abstract: Computer implemented methods and systems are provided that comprise, under control of one or more processors of a medical device, where the one or more processors are configured with specific executable instructions. The methods and systems obtain motion data indicative of at least one of a posture or a respiration cycle; obtain cardiac activity (CA) signals for a series of beats; identify whether a characteristic of interest (COI) from at least a first segment of the CA signals exceeds a COI limit; analyze the motion data to determine whether at least one of the posture or respiration cycle at least in part caused the COI to exceed the COI limit. Based on the analyzing operation, the methods and systems automatically adjust a CA sensing parameter utilized by the medical device to detect R-waves in subsequent CA signals; and detect an arrhythmia based on a presence or absence of one or more of the R-waves in at least a second segment of the CA signals.

Abstract: The disclosure relates to a device and method of obtaining an electrocardiogram for a subject. The method comprises receiving electrical signals from at least two head-mounted sensors; and analysing said electrical signals to resolve shape and timing information for each of the P-, Q-, R-, S-, and T-waves available for the subject over a number of cardiac cycles, to derive a composite electrocardiogram, ECG, in which the composite electrocardiogram is derived using signals only from said head-mounted sensors.

Abstract: A method for generating a propagation and velocity maps for cardiac wavefront propagation including cardiac arryhthmia, sinus rhythm, and paced rhythm. Activation time information is generated in the absence of any time alignment reference, wherein an estimated activation time is a weighted summation of potentially nonlinear and nonorthogonal candidate functions (CFs) selected from a bank of CFs. Time alignments between sequential recordings may be done by including binary level functions among selected CFs. Embodiments are applicable to single catheter mapping and sequential mapping, and are robust as confirmed by the ability to generate propagation maps and conduction velocity in the presence of multiple colliding wavefronts. The propagation and conduction velocity maps may be used for one or more of diagnosing cardiac arryhthmia, localizing cardiac arryhthmia, guiding catheter ablation therapy of cardiac arryhthmia, and guiding cardiac pacing therapy.

Abstract: An electrocardiography patch is provided. A backing includes an elongated strip with a midsection connecting two rounded ends. The midsection tapers in from each end and is narrower than each of the two ends. An electrode is positioned on each end of the backing on a contact surface to capture electrocardiographic signals. A circuit trace electrically is coupled to each of the electrodes in the pair. A battery is provided on an outer surface of the backing opposite the contact surface. Memory is provided on the outer surface of the backing to store data regarding the electrocardiographic signals. A processor is powered by the battery to write the data into the memory.

Abstract: An electrocardiography patch is provided. A backing forms an elongated strip with a mid-section connecting two ends of the backing. The mid-section is narrower than the two ends of the backing. An electrocardiographic electrode is provided on each end of the backing to capture electrocardiographic signals. A flexible circuit includes a pair of circuit traces electrically coupled to the electrocardiographic electrodes. A wireless transceiver communicates at least a portion of the electrocardiographic signals.

Abstract: Techniques for obtaining impedance data to provide an early warning for heart failure decompensation are described. An example device may be configured to measure subcutaneous impedance values, and increment an impedance score. In some examples, the device may use an adaptive threshold and fluid index in incrementing the impedance score. In some examples, the impedance score is compared to a threshold to determine a heart failure status of a patient. In some examples, may cause resets in fluid index values and/or determine positions or orientations of the device when determining the impedance score.

Abstract: In a method and system for automatically positioning a region of interest of a patient for a medical imaging examination in an isocenter of a medical imaging apparatus, the region of interest of the patient is brought into a patient receiving region of the medical imaging examination for a position-determination measurement, a position-determination measurement is performed to capture position-determination image data, the position-determination image data is analyzed to determine a position of the region of interest of the patient from the position-determination image data, and the patient is automatically positioned such that the position of the region of interest of the patient coincides with the position of the isocenter of the medical imaging apparatus.

Abstract: Accelerated acquisition of scan data by means of magnetic resonance to enable short echo times so that scan data of substances can also be acquired with a transversal relaxation time.

Abstract: A device includes a cylindrical body having a proximate end and a distal end. A three-axis magnetic sensor is mounted on the proximate end of the cylindrical body. The three-axis magnetic sensor includes an X-axis magnetic sensor sensitive to magnetic fields along an X-axis of the cylindrical body, a Y-axis magnetic sensor sensitive to magnetic fields along a Y-axis of the cylindrical body, and a Z-axis magnetic sensor sensitive to magnetic fields along a Z-axis of the cylindrical body.

Abstract: An endoscope system includes an insertion section, a first active bending section, a second active bending section, a position-information acquiring section, a first control section, a second control section, and a third control section. The first control section controls, based on a detection result of the position-information acquiring section, a first driving section of the first active bending section such that a first end portion of a first tubular section of the first active bending section moves away from a center point. The first control section controls a second driving section of the second active bending section such that a second end portion of a second tubular section of the second active bending section approaches the center point. The third control section controls the first driving section such that force in a direction of bending the first tubular section in a first bending operation acts on the first end portion.

Abstract: A spirometer turbine assembly is described, having a housing with a proximal end opening, a distal end opening and an airflow channel therebetween. A first flow director has a first plurality of flow director blades with distal edges that curve in a plane perpendicular to a longitudinal axis of the airflow channel, and a vane is connected to an axel positioned distal to the first flow director. A spirometer turbine assembly having an anti-static material is also described.

Abstract: There is provided a kit of parts for an exhaled breath condensate collection device. The kit comprises a mouthpiece module (100) comprising a breath passageway defined in the mouthpiece module (100) providing fluid conduction from a mouthpiece breath inlet port (122) for receiving exhaled breath to a mouthpiece breath outlet port (124) in use. The kit further comprises a collection vessel (300) for insertion into the device for cooling in use. The collection vessel (300) defines a sealed and resealable chamber for collecting exhaled breath condensate in use. The collection vessel has a vessel breath inlet (326) for admitting exhaled breath into the chamber.

Abstract: An image processing system according to the present invention includes at least one memory and at least one processor which function as: an acquiring unit configured to acquire information on a captured moving image: a detecting unit configured to detect, on a basis of the information acquired by the acquiring unit, an edge point of an affected area in a diameter direction thereof from a locus of light moving inside the affected area; and a providing unit configured to provide information on an outer periphery of the affected area on a basis of a plurality of points detected by the detecting unit.

Abstract: A neuromuscular sensing method includes transmitting an electrical stimulus from a distal end portion of an elongate stimulator extending within an intracorporeal treatment area of a subject and detecting an artificially induced response of at least two muscles of the subject in response to the transmitted electrical stimulus, each response being detected by a respective sensor in mechanical communication with the muscle. A graphical user interface (GUI) is transitioned from a first state to a second state; the first state indicating to the transmission of a stimulus with no artificially induced response detected, and the second state indicating the detection of the artificially induced response of the at least two muscles, and further identifying one of the at least two muscles as a primary muscle response.

Abstract: An assembly and a method is described. The assembly includes a platform, a motive source, a sensor, a controller and a computerized system. The computerized system has logic configured to cause a processor to send a signal to the controller to cause the motive source to move the platform through at least a portion of a range of inclination angles and to receive data indicating at least one of muscle activity, movement, and ground reaction force applied to the platform at a determined angle, and to cause the processor to analyze the data to determine an orthotic angle for a user's foot.

Abstract: A device for determining a parameter of the locomotion of animals has at least one marker with a tracker, and/or at least one sensor and an evaluation unit. The marker and/or the sensor are attached to a jacket provided for dressing the animal. The marker and/or sensor is arranged on the jacket so that the marker is arranged on the animal wearing the jacket having a defined spatial assignment to a parameter-relevant body location of the animal associated to the marker and/or sensor. The evaluation unit determines a parameter of the locomotion on the basis of a motion, detected by the tracker, of the parameter-relevant body location associated to the marker and/or on the basis of a motion, detected by the sensor, of the parameter-relevant body location associated to the sensor.

Abstract: The disclosed embodiments provide systems and methods for predicting presence of one or more neurological deficits. The system may include a microphone, a camera, one or more memory devices storing instructions, and one or more processors configured to execute the instructions to extract audio information including a period density entropy coefficient and a mel frequency cepstral coefficient from an audio feed received from the microphone. Additionally, the instructions may cause the processor to determine position and depth information of eye movement from a video feed received from the camera and detect features of interest including facial landmarks, spatial orientation of limbs, and positional information of limb movements from the video feed. The one or more processors may further extract the features of interest from the video feed and process the extracted features of interest by aligning the extracted features of interest to a common reference.

Abstract: The present invention relates to a liquid information sensor comprises at least more than one electrode set including a first electrode, and a second electrode which is disposed spaced apart from the first electrode and to which an alternating current signal is applied between the first electrode and the second electrode; and a ferroelectric layer including a first side in contact with the first electrode and the second electrode and a second side facing the first side and defining a receiving area for receiving the target liquid, and generating sound waves by physical vibration when the AC signal is applied.

Abstract: Wireless electrochemical measurements methods using minimally invasive micro-sensors that monitor response of cells to specific analytes are described. Micro-actuators integrated on a same chip as the micro-sensors are used to provide closed loop in-vivo local therapy on demand. An in-vivo bio-electronic system that can monitor the health of cell colonies and accordingly dispense corresponding therapeutic drugs is also described.

Abstract: A diagnostic transdermal patch which utilizes a microneedle array and an integrated biochemical assay to detect the presence of biomolecules which are associated with a specific condition or disease, such as mild traumatic brain injury (MTBI).

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor substrate, electrode or housing, an analyte indicator covering at least a portion of the sensor, and one or more optical signal stabilizing additives in an environment of the sensor.

Abstract: A tubing assembly for use in providing a flow of positive pressure breathing gas to a patient. The tubing assembly includes a manifold portion structured to receive the flow of positive pressure breathing gas, a number of tubular portions which each extend from the manifold portion to a distal end which is structured to be coupled to a patient interface for use in delivering the flow of positive pressure breathing gas to the patient, and a reflectance pulse oximetry sensor positioned in or on one of the number of tubular portions. The sensor is structured to be disposed adjacent the patient when the tubing assembly is disposed on the patient for determining blood oxygen saturation levels of the patient.

Abstract: A wearable device is described. The wearable device includes a housing having a back cover, and an optical mask on first portions of the back cover. The back cover includes a set of windows, with a first subset of windows in the set of windows being defined by an absence of the optical mask on second portions of the back cover, and a second subset of windows in the set of windows being inset in a set of openings in the back cover. An optical barrier surrounds each window in the second subset of windows. A set of light emitters is configured to emit light through at least some of the windows in the set of windows. A set of light detectors is configured to receive light through at least some of the windows in the set of windows.

Abstract: Devices, systems, and methods for patient sensing include a patient sensor having a light diffuser arranged to provide a light field in which photoelectric sensors can be positioned to provide enhanced detection of physiological parameters of the patient. The light diffuser is connected with a sensor baffle to assist in avoiding interference.

Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

Abstract: This disclosure relates to systems, media, and methods for quantifying and monitoring visual acuity, motor skill, and cognitive ability of user through measuring user activities while the user responds to prompts on an electronic device. Disclosed embodiments may receive image data from a user-facing camera, motion data from a sensor device attached to the user, location data from a touchscreen, and time data measuring a user's response times. Disclosed embodiments may provide graphical user interfaces to which the user responds and calculate health metrics based on characteristics of the user response. Disclosed embodiments may calculate visual acuity, motor skill, and cognitive ability metrics based on data measured, while the user responds to the graphical user interfaces. Disclosed embodiments may include comparing the metrics to respective baseline values and providing an alert when the metrics deviate from threshold values indicating a change in user health.