Abstract: An endovascular prosthesis comprising: a conduit formed by a wall structure surrounding a lumen; a sensor element configured to generate an electrical parameter shift in response to a physical event, the sensor element integrated in the wall structure of the conduit, the wall structure includes at least one wire structure, where at least a part of the wire structure include a first metallic conduit, a second metallic conduit, and a sensor disposed between the first metallic conduit and the second metallic conduit, where the first and second metallic conduits are conductors in a monitoring device detecting the electrical parameter shift in the sensor; wherein the sensor is either a variable capacitive sensor, and the first metallic conduit and the second metallic conduit form the electrodes of the variable capacitor; or a variable resistor configured to generate a resistance change in response to the physical event.

Abstract: The present invention provides a pulse wave conduction parameter measuring method and a pulse wave conduction parameter processing device. The method comprises: acquiring vibration information of a subject from one or more vibration-sensitive sensors configured to be placed at a predetermined position; generating hemodynamic related information on the basis of the vibration information; determining a first feature point and a second feature point in the hemodynamic related information, wherein the first feature point is a point related to an aortic valve opening time of the subject, and the second feature point is related to a pulse wave arrival time of the subject; and determining a pulse wave conduction time of the subject on the basis of the first feature point and the second feature point.

Abstract: An example medical device system and method includes accelerometer circuitry configured to generate at least one signal, a memory, and processing circuitry coupled to the accelerometer circuitry and the memory. The processing circuitry is configured to determine a first plurality of pulse transit times (PTTs), determine, based on the at least one accelerometer signal, a Sit-to-Stand transition, determine, based on the Sit-to-Stand transition occurring, a second plurality of PTTs after the Sit-to-Stand transition, and determine a likelihood that a person, such as a patient, may fall based on the first plurality of PTTs and the second plurality of PTTs.

Abstract: A pulse transit time measurement device includes a belt unit wound around a target measurement site of a user, an electrode group provided in the belt unit and including a four electrodes, a current source applying an alternating current between the first electrode and the second electrode, a potential difference signal detection unit detecting a potential difference signal between the third electrode and the fourth electrode, an electrocardiogram acquisition unit acquiring, based on the potential difference signal, an electrocardiogram corresponding to a waveform signal representative of an electrical activity of a heart of the user, a pulse wave signal acquisition unit acquiring, based on the potential difference signal, as a pulse wave signal, a waveform signal representative of an electrical impedance in the target measurement site of the user, and a pulse transit time calculation unit calculating a pulse transit time based on the electrocardiogram and the pulse wave signal.

Abstract: A biometric data measurement system and method, including a transmitting device including a measurement unit configured to measure a first biometric data, a setting unit configured to set a first reference time corresponding to an occurrence time of a first feature value of the first biometric data, and a transmission unit configured to transmit a signal at a time when a predetermined first time period has elapsed since the first reference time, and a receiving device including a measurement unit configured to measure a second biometric data, a setting unit configured to set a second reference time corresponding to an occurrence time of a second feature value of the second biometric data, and a reception unit configured to maintain an awaiting state for the signal during a third time period from a time when a second time period has elapsed since the second reference time.

Abstract: A low-cost blood pressure cuff includes a bladder assembly comprised of a flexible inner layer of a first material and a flexible outer layer of a second material. The first and second materials are weldable to each other. A top sheet has a first portion that overlies the outer layer and a tail portion extending longitudinally from the first portion. The third portion is comprised of a third material that is not weldable to itself. A perimetric bladder weld joint joining the inner layer, the outer layer, and the top sheet to each other. An enhanced embodiment of the cuff includes a bottom sheet having at least a first portion which underlies the inner layer and which is comprised of a fourth material which is not weldable to itself. The bladder weld joint extends into the bottom sheet thereby joining the bottom sheet to at least the inner layer.

Abstract: A blood pressure measurement device that measures blood pressure, and relates to a cuff unit.

Abstract: Technologies and implementations for wearable healthcare devices are generally disclosed. An example method performed by a wrist-wearable device includes: detecting, by a sensor, a physiological parameter of a user; determining, by a processor based on the physiological parameter, that the user is experiencing atrial fibrillation (AF); outputting, by a display, a visual signal indicating that the user is experiencing the AF; and transmitting, by a transceiver to a first external computing device, a first wireless signal indicating that the user experienced the AF.

Abstract: A biodegradable pressure sensor for measuring vital physiological pressures and for preventing the buildup of dangerous internal forces in impaired organs. The pressure sensor is constructed by depositing Mg or Mo on both sides of a PLLA film. This layered configuration (Mg/PLLA/Mg) or (Mo/PLLA/Mo) may then be encapsulated by layers of high molecular weight PLA. These materials are biodegradable such that after implantation, the sensor does not require invasive removal surgery that can damage directly interfaced tissues.

Abstract: A system includes signal acquisition circuitry and a processor. The signal acquisition circuitry is configured to receive multiple intra-cardiac signals acquired by multiple electrodes of an intra-cardiac probe in a heart of a patient. The processor is configured to extract multiple annotation values from the intra-cardiac signals, to select a group of the intra-cardiac signals, to identify in the group one or more annotation values that are statistically deviant in the group by more than a predefined measure of deviation, and to visualize the annotation values to a user, excluding the statistically deviant annotation values.

Abstract: A network of electrodes configured to sense and/or pace the heart, wherein the network of electrodes are in contact with an epicardial surface of the heart, within a wrapping sleeve that assist the heart as a whole, wherein the network of electrodes sense the heart by quantifying intrinsic electrical activities of the heart, and wherein the network of electrodes pace the heart by inducing an electrical impulse to the heart to control its contractile activities. The network may be interfaced with a controller system, wherein the controller uses spatial and temporal electrical activities of the heart muscles to generate electrical impulse to synchronize the wrapping sleeve around the heart with the heart. Also disclosed is a system configured to construct space-time mapping of cardiac electrical activities and/or propagation, and sensing effects of a first assist event of a prior beat and controlling a second assist event.

Abstract: A system is provided for taking an electrocardiogram of a subject. The system includes a wireless communications system; a first device which is disposable on a first limb of the subject, said first device containing a first tangible, non-transient memory device and a first sensor which measures a first electrophysiological signal of the user; a second device which is disposable on a second limb of the subject, said second device containing a second sensor which measures a second electrophysiological signal of the user and which is in communication with said first device via said wireless communications system; and a software program which is resident in said first memory device and which produces an electrocardiogram from the first and second electrophysiological signals measured by the first and second sensors.

Abstract: A dipole group quantification method includes quantitating a dipole group that are sources of signals based on positions of dipoles.

Abstract: In one embodiment, a method to display data collected by a wearable cardioverter defibrillator (WCD) is described. The method includes receiving raw heart rate data from one or more electrocardiogram (ECG) sensors. The method also includes classifying the heart rate data into one of a ventricular (VT) and supra-ventricular (SVT) segments based at least in part on the QRS width, recording the classification and time stamp of each VT and SVT heart rate, and generating one or more interactive displays of the VT and SVT segments.

Abstract: A method, computer program, and computer system for detecting and classifying atrial fibrillation by receiving data corresponding to an electrocardiogram (ECG) associated with a patient, extracting RR intervals from the received ECG data, determining previous RR intervals for each of the extracted RR intervals and aggregating features associated with the RR intervals and the previous RR intervals. Patterns associated with the aggregated features are classified, and the computer may determine that a sample of the ECG data corresponding to one or more of the classified patterns contains a pattern associated with atrial fibrillation.

Abstract: Techniques for triggering the storage or transmission of cardiac electrogram (EGM) signals associated with a premature ventricular contractions (PVC) include sensing a cardiac EGM signal of a patient via a plurality of electrodes, detecting a premature ventricular contraction (PVC) within the cardiac EGM signal, determining whether PVC storage criteria is met, in response to a determination that the PVC storage criteria is met, storing a portion of the cardiac EGM signal associated with the PVC, and in response to a determination that the PVC storage criteria is not met, eschewing storing the portion of the cardiac EGM signal associated with the PVC.

Abstract: Systems and methods for identifying potential ablation sites using electrical parameter data are provided. A method includes geometrically isolating an arrhythmogenic substrate in a three-dimensional geometry. The method further includes generating a first cumulative map from a first dataset including electrical parameter data for each vertex in the isolated arrhythmogenic substrate, and generating a second cumulative map from a second dataset including additional data for each vertex. The method further includes generating a third cumulative map from the first and second cumulative maps, and displaying the third cumulative map on the three-dimensional geometry to facilitate identifying potential ablation sites.

Abstract: A method of filtering an electrocardiogram (ECG) signal includes obtaining the ECG signal; applying a first transformation to the ECG signal to generate a transformed ECG signal; filtering the transformed ECG signal to generate a filtered transformed ECG signal; and applying a second transformation to the filtered transformed ECG signal to generate a filtered ECG signal.

Abstract: A muscle relaxation monitoring apparatus includes: a stimulating circuit that stimulates a nerve of a living body; a signal detecting circuit that detects an electric signal generated by a muscle reacting to the stimulation performed by the stimulating circuit; a reaction time calculating circuit that calculates a reaction time which elapses from the stimulation of the nerve by the stimulating circuit until the electric signal is detected by the signal detecting circuit; and a relaxation degree determining circuit that determines a muscle relaxation degree of the living body based on the length of the reaction time calculated by the reaction time calculating circuit.

Abstract: Systems and method for remote field measurement-based mapping of anatomical structures (e.g., using impedance image of electrical fields) are described. In some embodiments, an image of features within a target region is produced by analysis of a spatial pattern of field measurements made in a measurement region remote from the target region features; for example, but not exclusively, by treating the spatial arrangement of field measurements in some portion of the measurement region as indicating the spatial (e.g., angular and/or distance) arrangement of features (e.g., anatomical structure of topography and/or tissue type) in the target region.

Abstract: Medical apparatus includes one or more magnetic field generators, which are configured to generate magnetic fields within a body of a patient. An invasive probe includes an insertion tube having a distal end, which is configured for insertion into the body, and a plurality of flexible splines configured to be deployed from the distal end of the insertion tube. Each spline includes a flexible, multilayer circuit board and a conductive trace that is formed in at least one layer of the circuit board and is configured to define one or more coils, which are disposed along a length of the spline and output electrical signals in response to the magnetic fields. A processor is coupled to receive and process the electrical signals output by the coils in order to derive respective positions of the flexible splines in the body.

Abstract: The invention relates to an imaging method for radiologically guiding an instrument during medical interventions on an object (106, 203, 302) comprising: a) providing a first image (501, 602, 706, 806, 906, 1006, 1106) of said object followed by b) providing updated images on-the-fly during the intervention to an operator by measuring an undersampled set of projections of said object (106, 203, 302) and reconstructing said updated image based on changes between said first image (501, 602, 706, 806, 906, 1006, 1106) or an update of said first image (602) and said undersampled set of projections.

Abstract: Apparatus, systems, and methods are provided for localization of a region within a patient's body using markers implanted within the region. In an exemplary embodiment, a probe includes a distal end for placement against a surface of the region; one or more antennas for transmitting electromagnetic signals into and receiving reflected signals from the region; a light source for delivering light pulses into the region whereupon the markers modulate reflected signals. A processor of the probe processes the modulated reflected signals at one or more of the surface locations to determine marker locations within the region to obtain a reference frame, determine distance values corresponding to distances from the respective markers to the distal end at each of the surface locations, and determine coordinates of the surface locations relative to the reference frame to generate a three dimensional model of the body region.

Abstract: A tablet, method of forming the tablet, and article of manufacture that includes the tablet. The tablet can include a layer of a first dissolvable material and a first circuit positioned on the layer of the first dissolvable material. The tablet can also include a layer of a second dissolvable material coating the first circuit, and a second circuit positioned on the layer of the second dissolvable material. The method can include providing the tablet, and determining a dissolving pattern for the tablet.

Abstract: The present invention is directed to locating and imaging with a swallowable sensor device disposed in a patient. The swallowable sensor device transmits an acoustic signal from inside a patient's body. A plurality of sensing elements receive the acoustic signal. A computation module determines a location of the swallowable sensor device with respect to the plurality of sensing elements based on the acoustic signal received by at least a subset of the plurality of sensing elements. A three-dimensional image of an interior portion of the patient can also be formed based on the received acoustic signal. The three-dimensional image may be formed by stereoscopically displaying two two-dimensional images of the interior portion, wherein the two two-dimensional images correspond to the swallowable sensor device being located at two different locations. Alternatively, the three-dimensional image may be formed by computing three-dimensional pixels of the interior portion.

Abstract: A respiration gas monitor device (100) includes a pump (110) connected to draw a flow of respired air, a pressure sensor (150, 160) is connected to measure an air pressure signal responsive to the flow of respired air, and a pressure transducer (180c). Electrical circuitry (170, 180) is operatively connected to measure flow across the pressure sensor. A gas component sensor (190, 192, 194) is arranged to monitor a target gas in the flow of respired air.

Abstract: Various methods of diagnosing and monitoring a subject infected with a Plasmodium parasite are described. Also, compositions and methods for attracting mosquitos are also described.

Abstract: Provided is a respiratory state estimating device including a pulse wave signal acquiring unit that acquires a pulse wave signal from a portion of a living subject, a pulse rate calculating unit that calculates a pulse rate of the living subject based on the pulse wave signal, and a respiratory state estimating unit that estimates a respiratory state of the living subject based on the pulse rate. Also, provided is a respiratory state estimating method including optically acquiring a pulse wave signal from a portion of a living subject, calculating a pulse rate of the living subject based on the pulse wave signal, estimating a respiratory state of the living subject from the pulse rate.

Abstract: A compliance monitoring module for an inhaler comprising: a miniature pressure sensor, a sensor port of said sensor being configured to be pneumatically coupled to a flow channel of said inhaler through which a user can inhale; a processor configured to: receive data from a sensing element of the pressure sensor; receive data from a mode sensor configured to detect when the inhaler changes from an inactive mode to an active mode; and based on said data from said pressure sensor sensing element and said data from said mode sensor, compile a compliance report; and a transmitter configured to issue said compliance report.

Abstract: A load cell apparatus includes a base member, a cap member, a number of first members provided between the base member and the cap member and forming at least a portion of a support wall of the load cell apparatus, and a plurality of strain gauges directly coupled to the number of first members, the plurality of strain gauges being positioned to measure an axial load applied to the load cell in a direction extending from the cap member to the base member.

Abstract: A method for automatic identification of a measurement item is provided. The method comprises acquiring, via an image acquisition module, gray values of pixels of a specified section image corresponding to ultrasonic echoes generated by reflection of ultrasound waves by a tissue under examination; identifying, via an identification module, at least one measurement item corresponding to the specified section image based on the gray values of the pixels; and measuring, via a measuring module, a measurement item parameter of the specified section image based on the measurement item identified. Because the measurement item of a specified section image can be automatically identified based on the content thereof, the user does not need to move a trackball to select measurement items, and therefore efficiency is increased.

Abstract: A method includes generating, via a camera, image data that is reproducible as an image of at least a portion of a subject. The method also includes receiving, via a sensor, first biomeasurement data associated with the subject, the first biomeasurement data including a first biomeasurement of the subject. The method also includes verifying the first biomeasurement of the subject based at least in part on a comparison between at least a portion of the image data and at least a portion of the first biomeasurement data.

Abstract: An article of clothing that can be worn by a user to sense activity. A first conductive fabric layer is positioned in a location of the article of clothing that is deformed when worn. A second conductive fabric layer is also positioned in the location of the article of clothing. A foam layer is positioned between the first and second conductive fabric layers. At least one conductive lead is coupled to at least one of the first or second conductive fabric layers. Application of a force at the location due to activity of the user causes a change in an electrical parameter of the conductive lead.

Abstract: An activity tracking fashion-accessory kit includes an electronic system configured to measure parameters concerning physical activity when worn by a user and a plurality of resilient bands each including an enclosure configured to temporarily receive the electronic system in a manner that secures the electronic system within the resilient band, respectively. Each one of the respective plurality of resilient bands are sized and configured for use in each of a first configuration as a wrist band and a second configuration as a hair tie. The electronic system is housed in a housing that interchangeably fits within each of the respective enclosures, and configured to track a step count of the user when enclosed in any of the respective enclosures with the respective resilient band worn by the user in each of the first configuration and the second configuration, respectively.

Abstract: A method and a related device to determine the kinetic state of a subject includes the steps of determining a signal indicative of the acceleration trend on the three Cartesian axes; processing the signal to limit the frequency band and preferably reduce artifacts and compensate the offset of the output signals from a multi-axial measurement system; analyzing frequency and spectrum through the transformation of the signal with the Fournier transform; computing the power spectral density for each Cartesian axis; and comparing the spectral density with a characteristic pattern of a movement.

Abstract: The invention provides an Optical Coherence Tomography (OCT) system capable of acquiring two orthogonally polarized depth scans from a target such as the fingerprint region of a finger. In the preferred embodiment the birefringence of tissue components and, optionally, other aspects of the target are measured in order determine a characteristic of the target, such as whether it is real of fake finger.

Abstract: An apparatus for inspecting a biological tissue uses a pH-sensitive coating material to determine whether the tissue is normal or cancerous. The coating materials placed in contact with the tissue to be excited by an excitation light. The coating material is arranged to provide a response signal indicative of the pH value of the tissue. Using a fiber bundle having a plurality of optical fibers forming a linear array or a two-dimensional array adjacent the coating material, the imaging of localized surface pH in the biological tissue can be achieved using the response signal through each of the optical fibers. The fiber bundle can be arranged as a probe to examine the tissue for providing direct mapping of the tumor margin via a display, so that a surgeon can inspect the tissue in real-time.

Abstract: Analyte sensors and methods of use thereof, the analyte sensors comprising a base substrate, a first conductive layer positioned on a first side of the base substrate and a fiducial mark positioned on a portion of the analyte sensor. The fiducial mark is indicative of a location of at least the first conductive layer on the base substrate.

Abstract: The present document relates to a tester for testing pulse oximeters, wherein the tester is configured for use with a plurality of measuring devices. The tester device may comprise a plurality of light detector sets and a light emitter set, wherein each of the plurality of light detector sets may be used to trigger the light emitter set. Such an arrangement may allow the tester to be used with a transmissive type pulse oximeter as well as with a reflective type pulse oximeter.

Abstract: Methods, computers, and systems used to improve accuracy of analyte level measurement of an in vivo positioned analyte sensor are disclosed herein. The methods, computers, and systems disclosed herein may be used to provide a calibrated analyte level. Specific embodiments relate to methods, computers, and systems for improving accuracy of glucose measurement of an in vivo positioned glucose sensor.

Abstract: N-type polymer based electrochemical devices include one or more source electrodes, one or more drain electrodes, one or more channels, a gate electrode, and an electrolyte solution are disclosed. The channels include one or more n-type polymers and one or more enzymes. The gate electrode includes one or more n-type polymers and one or more enzymes. The source and the drain electrodes are electrically connected by the corresponding channel. The electrolyte solution contains one or more metabolites capable of reacting with the one or more enzymes in the channel and the gate electrode and is in electrical contact with the channel and the gate electrode. Saturation current that flows through the channel increases when the metabolites react with the enzymes to produce electrons, which are directly transferred to the n-type polymers at the gate electrode and the channel. Methods of making and using the n-type electrochemical device are also disclosed.

Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte, such as blood glucose. An inserter having a retractable introducer is provided for subcutaneously implanting the sensor in a predictable and reliable fashion.

Abstract: A computer implemented method is disclosed for providing adaptive control of a gas mixture for delivery to a patient via a separate external gas blender system. The computer implemented method includes receiving first SpO2 data from a regional oximeter via a regional oximeter interface; determining first PaO2 data using a first lookup table derived from a first sigmoid shaped oxyhemoglobin dissociation curve; determining a first gas mixture value using the first PaO2 data; and transmitting first adaptive feedback control data including the first gas mixture value to the separate external gas blender system via a gas blender interface.

Abstract: A laryngoscope system includes a monitor having communication circuitry and that communicates physiological parameter information to communication circuitry of a paired laryngoscope. The paired laryngoscope includes a camera and a display configured to display image data from the camera. A processor of the laryngoscope is programmed to generate instructions to provide a physiological parameter indicator via the laryngoscope based on the received physiological parameter information from the monitor.

Abstract: The present invention relates to a device for measuring a physiological parameter of a human limb such as peripheral capillary oxygen saturation. The device comprises a hollow elastic sleeve of a predetermined shape comprising a cavity having a closed-loop cross-section for enclosing the limb; first and second arms, each comprising a hinge portion between a coupling portion and a handle portion, the coupling portion of the first and second arms being adapted to be coupled, respectively, to first and second diametrically-opposite longitudinal sections of the sleeve; and a physiological sensor for interacting with the limb enclosed in said cavity. The hollow elastic sleeve holds the first and the second arms and causes their hinge portions to mutually engage to form a hinge mechanism so that, by applying a compression force on the handle portions, the first and second arms rotate about the hinge mechanism expanding the cavity, allowing the limb to be received therein.

Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.

Abstract: Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.

Abstract: A catheter system may include a catheter adapter, a catheter extending distally from the distal end of the catheter adapter, and a needle hub coupled to the catheter adapter. The needle hub may be transparent, and a needle may be secured within the needle hub. The catheter system may also include a flow control plug coupled to the proximal end of the needle hub. In some embodiments, a flashback pathway may be disposed between an outer surface of the flow control plug and an inner surface of the needle hub. In some embodiments, the catheter system may include an inner barrel and an outer barrel, and the inner barrel and the needle hub may be configured to move proximally within the outer barrel to retract the needle. The flashback pathway may be disposed between an outer surface of the needle hub and an inner surface of the inner barrel.

Abstract: A biological fluid collection device that is adapted to receive a blood sample is disclosed. The biological fluid collection device includes a housing, a puncturing element transitionable between a pre-actuated position wherein the puncturing element is retained within the housing and a puncturing position wherein at least a portion of the puncturing element extends through the housing, and a cartridge removably connectable to a portion of the housing. After collecting a blood sample, the cartridge is removable from the housing and the cartridge is able to transfer the blood sample to a point-of-care testing device. The biological fluid collection device provides a closed system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer.

Abstract: The present disclosure relates to a system for remote assessment of a patient, comprising: a first device associated to a physician, a second device associated to the patient, a medical device associated to the patient, wherein the second device is configured to communicate with the medical device, and wherein the medical device is configured to be programmed via the second device, wherein the first device is further configured to communicate with the second device, and wherein the second device is configured to be controlled via the first device, and wherein the second device is configured to acquire data indicative of at least one physiological parameter or of several physiological parameters of the patient. Furthermore, a method for remote assessment is provided.