Abstract: Disclosed are plunger assemblies which include a plunger sleeve, a plunger rod and an axial protrusion disposed within an inner cavity of the plunger sleeve. Application of a distal force onto the plunger via the plunger rod causes the axial protrusion to contact and apply pressure to an engagement surface in the inner cavity. The engagement surface is configured to receive distal force from the end of the axial protrusion. This causes the plunger to elongate and slightly constrict, thus reducing break loose force and facilitating transition from storage mode to dispensing mode of the plunger.

Abstract: A dosage sensing module for or in a pen drug delivery device and comprising a power source unit, a processor unit and a dosage sensor unit with a first sensor part adapted to be fixed to a part not rotating during dose expelling and comprising a flexible printed circuit board sheet on which a pattern of individual electrical conductive sensor areas are arranged. The sensor unit further comprises a second sensor part adapted to be fixed to the piston rod to follow the rotation thereof during dose expelling. The second sensor part comprises individual structures that together with the conductive sensor areas are adapted to, upon relative rotational movement between the first and second sensor part, provide electrical signals to a processor unit indicative of the relative rotational position between the first and second sensor part.

Abstract: An autoinjector apparatus is disclosed which comprises a single-use cassette and an autoinjector. The cassette comprises a housing and a sleeve movably disposed in the housing. A syringe may be disposed in the sleeve and secured therein with a lock cap. The lock cap is affixed to a distal end of the sleeve and contacts the distal end of the syringe. A shield remover extends through an opening in a proximal end of the housing for removing a needle shield which covers a needle of the syringe. A cassette identification arrangement is provided on a surface of the housing to enable the autoinjector to identify the cassette. The autoinjector is provided with a detector for reading the cassette identification arrangement.

Abstract: Provided is a tip for intra-tympanic injection capable of allowing a practitioner to accurately recognize an injection location and preventing the practitioner from piercing regions of an external auditory meatus other than the eardrum with an injection needle, in case of piercing the eardrum with the injection needle.

Abstract: An example drug delivery device includes a syringe assembly including a needle. The drug delivery device includes a handle carrying the syringe assembly and including a first portion, a second portion, a tapered surface, and a window. The first portion being wider than the second portion. The tapered surface extending from the first portion to the second portion. The needle of the syringe assembly adapted to extend from adjacent the second portion during an injection procedure. The window positioned between the first portion and the second portion and adapted to allow contents of the drug delivery device to be viewed. The drug delivery device includes a base adapted to be positioned adjacent the second portion of the handle during at least the injection procedure. The base being wider than the second portion of the handle and adapted to increase stability of the drug delivery device during the injection procedure.

Abstract: According to an embodiment, a medicine injection device comprises a medicine storage unit receiving a medicine cartridge storing a medicine, a needle unit connected with the medicine cartridge and injecting the medicine to a user, a driver configured to apply an external force to the medicine storage unit, a temperature sensor measuring a temperature of at least one of the medicine storage unit, the needle unit, the driver, and an outside of the medicine injection device, and a controller determining a medicine state indicating whether the medicine deteriorates based on the temperature measured by the temperature sensor and controlling the driver according to the determined medicine state to thereby determine whether to block the injection of the medicine.

Abstract: An aerosol generator is positioned adjacent to a patient as an attachment to a trocar. The trocar has an entry port for insufflation gas. Aerosol generated by a vibrating element is entrained in the insufflation gas and the mixture is delivered through the trocar. The aerosol may contain a medicament. The trocar may be a conventional trocar. Such trocars are typically used for a camera. The delivery of the aerosolized medicament can occur at the start of the procedure and be delivered in bolus. At the start of the procedure, the peritoneum is being inflated by means of the flow of insufflator gas. This gas flow will help to entrain the aerosolized medicament to the pneumoperitoneum regions. The surgeon can temporarily remove the camera from the trocar port to facilitate insertion and positioning of the aerosolizing unit.

Abstract: Handheld carboxy therapy applicators are disclosed. In one implementation, a handheld carboxy therapy applicator includes a heater module, a humidification module, and a hypodermic needle. The heater module is configured to receive a flow of gas and to warm gas within the flow of gas. The humidification module is in fluid communication, such as in a serial connection, with the heater module. The humidification module is configured to receive the flow of gas from the heater module and to humidify the gas within the flow of gas. The hypodermic needle is in serial connection with the humidification module. The hypodermic needle is configured to receive the flow of gas from the humidification module and to inject the flow of gas into a tissue of a patient.

Abstract: The present invention relates to an inhaler mouthpiece device for use as an accessory aid for metered dose inhalers and spacers used along with such inhalers. The device removably attachable to the metered dose inhaler simplifies and assists a patient's inhaling effort to advance an inhaled medication into lungs of the patient.

Abstract: A nasal cannula system having nasal prongs with an ancillary delivery system for a treatment fluid into a patient wearing the nasal cannula without removing the cannula. The nasal prongs have parallel ports that fluidly connect the delivery system to the nasal ports on the nasal prongs. The delivery system provides the treatment fluid in an aerosolized form. This configuration combines the aerosolized treatment fluid with the air or other fluid ordinarily delivered by the nasal cannula. The system may also use airway tubes having a generally semi-circular cross-section with an internal rib extending the length of the tube. The semi-circular cross-section provides a flat exterior surface for abutment or contact with a patient's skin and the rib prevents pinching closure of the airway tube.

Abstract: A rebreathing apparatus having inhaled oxygen mixing and exhaled carbon dioxide removal functions, enabling rebreathing by maintaining the amount of breathing oxygen by inhalation and removing carbon dioxide discharged by exhalation. The rebreathing apparatus includes a mask having one side to which an inhalation hose is connected and the other side to which an exhalation hose is connected; an exhaled breath storing container storing exhaled breath; a filter removing carbon dioxide; an inhaled breath storing container storing the air having passed through the filter; an oxygen storing container supplying oxygen to the inhalation storing container; a decompressor installed at an inlet of the oxygen storing container; an oxygen mixing module mixing the oxygen discharged through the oxygen supplying hose with the air; and a controller controlling operations of the exhaled breath storing container, the inhaled breath storing container, the oxygen storing container, the filter, and the oxygen mixing module.

Abstract: A program for controlling a respiratory assistance device that is connected to a user's airway and regulates an airway pressure to assist ventilation has a plurality of different respiratory assistance modes. The respiratory assistance program causes a computer to realize an input reception function that receives an input of setting for a respiratory assistance mode during operation of an air blower that blows air to the user's airway, and a flow rate control function that, when the input reception function receives the input of setting, controls a flow rate from the air blower in reflection of a result of the input of setting. A respiratory assistance device in which a user can change setting to select a comfort pressure and flow rate is provided by using such a program.

Abstract: The present disclosure relates to a system for detection of leakage or abnormal resistance in a ventilation system (1) comprising a breathing apparatus (2) providing mechanical ventilation to a patient (3). The system comprises a bioelectric sensor arrangement (27) for detecting a bioelectric signal indicative of the patient's effort to breathe, and a control computer (15) configured to receive the bioelectric signal detected by the bioelectric sensor arrangement (27). The control computer (15) is further configured to determine a change in the bioelectric signal, and to establish leakage or abnormal resistance in the ventilation system (1) based on the change in the bioelectric signal.

Abstract: The present invention relates to a ventilation device (10) for mechanical ventilation 1200 of patients, comprising an operating device for setting at least one ventilation parameter (110, 112, 114, 116; 112, 110, 112, 114, 116, 120, 122, 130), having a manipulation element (22) that can be manually operated by an operator to manually set the at least one ventilation parameter (110, 112, 114, 116; 112, 110, 112, 114, 116, 120, 122, 130), and a control unit (100) that is designed to automatically determine a target value for the at least one ventilation parameter (110, 112, 114, 116; 112, 110, 112, 114, 116, 120, 122, 130) on the basis of detected values of characteristic variables; the operating device has a first haptic feedback unit associated therewith which is designed to control the manipulation element (22) in terms of a first haptic feedback such that a position of the manipulation element (22) corresponding to the target value of the at least one ventilation parameter (110, 112, 114, 116; 112, 110, 112

Abstract: A method and a circuit system for driving a nebulizer are provided. When the nebulizer receives acoustic waves, a control circuit extracts audio signals from the acoustic waves. Afterwards, the control circuit determines if the audio signals are within a predetermined frequency range, and can determine whether or not to drive a circuit to produce an aerosol based on the audio signals. Further, a volume of the acoustic waves can also be used to determine whether or not to produce the aerosol, and also determine an output rate of the aerosol. The circuit system of the nebulizer includes an audio receiver for receiving the acoustic waves, an aerosol generator for producing the aerosol, and the control circuit used to control a driving circuit of the aerosol generator to drive a vibrational element to produce the aerosol through vibration in response to the audio signals and the volume.

Abstract: An integrated multimodal colorimetric based aspiration detection and intubation placement verification system for an endotracheal tube and associated method includes a housing configured to be coupled to the endotracheal tube whereby patient exhalation can flow through an internal passage of the housing, and colorimetric based sensors within the housing and configured to come into contact with the patient exhalation, where the colorimetric based sensors are visible from the exterior of the housing, and wherein the colorimetric sensors include at least two of i) CO2 sensor, ii) a sensor for a first gastric acid, iii) a sensor for a second gastric acid different from the first gastric acid, and iv) a PH sensor. An associated method is disclosed. The integrated multimodal colorimetric based system can be used with other respiratory devices other than endotracheal tubes.

Abstract: A cleaning device, system and method for use with an ETT or tracheostomy ventilation tube 60, a ventilator machine 900, a source(s) 602 of fluid (for example, pressurized or unpressurized) and a source(s) of suctioning 603 is disclosed. In some embodiments, the cleaning device is useful for cleaning an inner surface of the ventilation tube 60 and/or for preventing or hindering the accumulation of biofilm thereon. In some embodiments, it is possible to clean biofilm or any other material on the inner surface 201 by delivering fluid into an interior of the ventilation tube, wiping the tube interior with a width-expanded wiping element (e.g. an inflated balloon) by longitudinal motion of the wiping element, and suctioning material out of the ventilation tube.

Abstract: Disclosed is a three-cavity flushable fish mouth laryngeal mask airway catheter, including a cover, the cover is provided with a respiratory chamber for communicating with a respiratory tract and a digestive chamber for communicating with a digestive tract; the digestive chamber is provided with a digestive opening for communicating the digestive chamber and the digestive tract; a peripheral wall of the digestive chamber is tapered from an end away from the digestive opening to the digestive opening; an edge of the digestive opening includes a plurality of protrusions; and the plurality of protrusions are configured to be close to each other due to a squeezing force during a process of inserting the three-cavity flushable fish mouth laryngeal mask airway catheter into a throat to narrow the digestive opening.

Abstract: A tracheal sampling device is used to collect or acquire cells from an animal, such as at or near the tracheo-bronchial or larynx of an animal. The device includes a flexible and elongated shaft or stem, and a collection member at a distal end of the device. The collection member could be a swab or other member to best collect mucus. The device is used by inserting the collection end into an animal to position the collection member at or near the cell collection site, which may be in or around the larynx. The collection member is removed after collecting cells, which can be reviewed, tested, or otherwise managed to determine the presence of a disease or other bacteria. The length of the shaft or stem allows for optimal positioning of the swab in a variety of animal species and ages. The device can be disposed after each use.

Abstract: A manually articulated stylet assembly for placing an endotracheal tube. The stylet assembly has a steering shaft that carries a flexible distal tip at one end and is attached to a handle at the other end. The distal tip is manipulated via sheathed cables controlled by a remote actuator in the handle. A biasing member inside the remote actuator maintains continuous tension on the cables to improve control. A video camera is carried in a recessed lens pocket in the steering shaft but spaced from the distal tip. The camera FOV captures movement of the distal tip with foreshortened perspective. A collar seat in the handle receives the collar connector of a standard endotracheal tube, providing quick disconnect when removing the stylet assembly upon placement.

Abstract: A fixation device (1) for a medical line (L) to a patient is provided. The medical line may be a wire, a tube, an endotracheal tube or similar. The fixation device comprises a support member (3) supporting a retainer (5), the retainer defining an axis and being adapted to retain the medical line extending in axial direction. The retainer comprises an enclosure (25) for radially retaining the line and a clamp (27). The clamp is configured to provide a crimping force around the axis for fixing the line in at least axial direction, preferably also radial direction, relative to the enclosure.

Abstract: A mask is disclosed that has a gas outlet which is quiet and provides for a diffused outlet flow of gases. The outlet is preferably a slot formed between a hollow body and cover over said hollow body. The mask also preferably extends and seals under a user's chin in use.

Abstract: A cushion for use in a system providing a flow of breathing gas to the airway of a patient includes a first end having a sealing flap structured to sealingly engage a surface of the patient about an airway of the patient and a second end adapted to receive the flow of breathing gas. A wall portion extends between the first end and the second end and defines a passage which extends between the first end and the second end and which is structured to communicate the flow of breathing gas from the second end to the first end. The wall portion includes a notch which is positioned and structured to deform in a predetermined manner such that an angle which the wall portion makes with a longitudinal axis of the passage increases from a first value to a second value upon deformation of the notch.

Abstract: A nasal cannula system for use in ventilator systems, particularly continuous positive airway pressure (CPAP) systems. The nasal cannula system has a nasal body with nare prongs that extend into a patient's nostrils when worn. The ventilator system includes a ventilator on an inhalation side and either a bubble chamber or a variable resistance valve on the exhalation side. The inhalation side may include a heater/humidifier in-line with the supply tube so as to treat the air before application. The airway tube may have a generally semi-circular cross-section so as to provide a flat exterior surface for abutment or contact with a patient's skin.

Abstract: A system includes an oxygen supply; one or more sensors configured to generate output signals conveying information as to whether the patient is in an inspiratory phase or in an expiratory phase; one or more valves; and a computer system. The one or more valves have a) a first configuration in which the one or more valves operate to recover an excess flow of the oxygen-enriched breathing gas during the inspiratory phase, and b) a second configuration in which the one or more valves vent an exhalation flow of the patient during the expiratory phase to atmosphere. One or more physical processors are programmed with computer program instructions which, when executed cause the computer system to provide input to the one or more valves based on the output signals, the provided input causing movement of the one or more valves between the first and second configuration.

Abstract: A configurable oxygen concentrator for providing various flow rates and volumes of concentrated oxygen to a patient includes an electro-mechanical assembly having a housing with a first face, a second face and an outer surface. The oxygen concentrator also includes a first battery, a second battery, a first adsorbent container and a second adsorbent container. The first and second batteries are removably mountable to the first face and the first and second adsorbent containers are removably mountable to the second face to permit modification of the concentrated oxygen capacity and operating life of the concentrator as the patient progresses through different stages of a breathing disease. The first battery has a first battery capacity that is less than a second battery capacity of the second battery. The first adsorbent container has a first adsorbent capacity that is less than a second adsorbent capacity of the second adsorbent container.

Abstract: A humidification device (200A) includes a reservoir (216), a vaporizer (250), a water supply passage (230), a gas introduction passage (240), a gas introduction source (260), and a controller. The reservoir (216) stores water. The vaporizer (250) vaporizes the water supplied to the vaporizer (250). The water supply passage (230) is connected to the reservoir (216) and the vaporizer (250) and filled with the water flowing from the reservoir (216). The gas introduction passage (240) is connected to an intermediate position of the water supply passage (230). The gas introduction source (260) introduces gas into the water supply passage (230) through the gas introduction passage (240) so as to push out, by using pressure of the introduced gas, toward the vaporizer (250) the water with which the water supply passage (230) is filled. The controller controls operation of the gas introduction source (260).

Abstract: The present disclosure pertains to a system and method for determining whether a subject is likely to be disturbed by therapy levels of stimulation provided to the subject during sleep sessions. The present system is configured to automatically identify sensitive users using electroencephalogram (EEG) information from a reference sleep session with or without stimulation. For reference sleep sessions without stimulation, the alpha activity in detected deep sleep is used to predict whether the subject is likely to be disturbed by therapy levels of stimulation. For reference sleep sessions with stimulation, the acute increase in EEG delta (e.g., 0.5-4 Hz) power and/or an arousability index are used to predict whether the subject is likely to be disturbed by therapy levels of stimulation.

Abstract: A fragrance suitable for a user can be provided. A mobile terminal includes: an acquisition unit that acquires a psychosomatic state from a physiological index of a user; an input unit that inputs future information of the user; a determination unit that determines a recipe including one or more types and a mixing ratio of one or more perfumes based on the psychosomatic state and the future information; and a communication unit that transmits the recipe to a fragrance generation device.

Abstract: Briefly summarized, embodiments disclosed herein are directed to apparatus and methods for removing an occlusion from an indwelling catheter. The system can include a pressurized fluid conduit for delivering pressurized fluid to an occlusion site, and ablating the occlusion. A negative pressure source in fluid communication with the catheter lumen can then aspirate the occlusion. The positive pressure source can provide a pulsed pressurized fluid to facilitate ablation. The system can also include tip tracking and tip location systems to ensure the pressurized fluid conduit does not extend beyond the catheter lumen, causing damage to the vasculature. The system can further include an ultrasound transducer, coupled with one of the catheter and the pressurized fluid conduit to provide ultrasonic wave energy to the occlusion to further facilitate ablation thereof.

Abstract: A device, which may be a veterinary Foley-type urinary catheter for use with feline patients, and more specifically, male feline patients is described herein. The device is of sufficient size to pass through a male feline's urethra and without the need to be sutured in place to secure to the patient. The catheter may include a proximal portion configured to engage accessories, tools and instruments that may pass through the proximal portion into the catheter portion of the device. The proximal portion may include two separate tubular arms that may engage these accessories to allow fluid passage easily through the device as well as the tools and instruments. The catheter portion may be approximately 3 to 5 Fr in diameter and may further include a balloon residing at the distal portion of the catheter. The entire length of the catheter portion may be approximately 22 cm to 36 cm and include a taper toward a distal tip.

Abstract: A flexible guidewire assembly has an energy-emitting device configured to be selectively activated in response to receiving a first activation signal transmittable from a control assembly. This is done in such a way that the energy-emitting device, once activated, emits a first amount of electro-magnetic energy. The first amount of electro-magnetic energy has a first strength that is (A) sufficient for detection by a medical-imaging sensor positioned in the confined space defined by the living body, and (B) insufficient for vaporization of any tissue of the living body.

Abstract: A guidewire for use in intravascular procedures has an inner coil that is radiopaque and an outer coil that is non-radiopaque at the distal end of the guidewire. The radiopaque inner coil is visible under fluoroscopy so that the physician can monitor the location of the distal end of the guidewire during a procedure. The inner coil and the outer coil can be formed from a single wire or a multi-filar wire. The inner coil and the outer coil can have any of the following cross-sections for enhanced torquability: I-beam; vertical rectangular; vertical ellipse; square; peanut shape; vertical hexagonal; horizontal hexagonal; and horizontal ellipse.

Abstract: A device may include a catheter and a support tube. The catheter includes a lumen extending therethrough. The catheter is sized and shaped to extend through an endoscopic shaft to a target tissue within a living body. The lumen is sized and shaped for receiving a puncturing device therethrough. The catheter includes a first catheter portion distal to a second catheter portion. The first and second catheter portions are formed from different materials. The first catheter portion has a flexible curved distal end. The tube is fixed about an outer surface of a proximal end of the first catheter portion and an outer surface of a distal end of the second catheter portion.

Abstract: A guidewire for use in intravascular procedures has an elongated core member including a proximal core section having a uniform diameter. One or more parabolic grind profile sections extend distally from the distal end of the proximal core section and provide a linear change in bending stiffness and a high degree of torque to the distal portion of the guidewire.

Abstract: A shaping tool is used to form a bend in the distal end of a guidewire. The guidewire distal end is inserted through a channel and into a cavity of the shaping tool. Using hand pressure, a first member is moved axially relative to a second member of the shaping tool, thereby moving the cavity relative to the channel and imparting a bend in the distal end of the guidewire.

Abstract: The application relates to vascular catheters, in particular to vascular catheter systems (100) which are configured to mix blood. Aspects relate to a mixer sheath (110) for a vascular catheter, a method of manufacturing a mixer sheath, a catheter sheath, a catheter, a method of deploying a vascular catheter, a method of removing a vascular catheter, a method of deploying one or more blood mixing elements, a method of using a catheter system and a method of reversing the deployment of a blood mixing element. The mixer sheath comprises a tube having a wall patterned with a line of weakness (212) which is configured to cause buckling of a portion of the tube wall when a longitudinal compression force is applied to the tube to form a blood mixing element (111) which extends radially outwards with respect to a location of the portion of the tube wall prior to buckling.

Abstract: Intraluminal and endovascular devices and methods of manufacturing intraluminal and endovascular devices may be provided. In one implementation, an intraluminal device may include a sheath having a flexible distal bending segment and a core wire arranged within the sheath. The core wire may include a distal end portion doubled back in a loop within the sheath such that the distal tip of the core wire is situated proximally from the loop. The intraluminal device may also include a movement restrictor within the sheath that is configured to limit axial movement of the distal tip of the core wire. Limiting the axial movement of the core wire distal tip may cause the loop of the core wire to buckle, resulting in a bend in the distal bending segment of the sheath, when a force is exerted on the core wire.

Abstract: A catheter having a catheter shaft that has a more uniform construction throughout its length and is able to provide more than one deflection curvature. The catheter shaft includes a flexible outer tubular member, and a less flexible inner tubular member extending through the outer tubular member in a proximal section of the catheter shaft, wherein the inner tubular member is afforded longitudinal movement relative to the outer tubular member. The catheter also includes at least one puller wire extending through the inner tubular member to deflect a distal deflection section of the catheter shaft, wherein longitudinal movement of the inner tubular member relative to the outer tubular member enables an operator to select and set a deflection curvature of the distal deflection section.

Abstract: The invention relates to a catheter for dialysis, in particular for long-term application, comprising a proximal end for introducing into a blood vessel, a distal end for extracting blood and for introducing purified blood, and at least one fixing means surrounding a tube section for fixing the catheter on the patient. The fixing means has a receiving part and an opening part, wherein, with respect to the receiving part, the opening part can be moved from an opening position, in which the tube section is insertable into the fixing means, into a closing position, in which the tube section is fixed in the fixing means.

Abstract: A device that has a head having an inside surface and a base integral with the head, the head smoothly transitioning to the base, the base comprising a first opening where the head transitions to the base and a lateral circular channel that travels from the first opening to a second opening on a bottom of the base. Further, the device has a clamp that clamps the base to a catheter.

Abstract: Some embodiments of a medical device anchor system include an anchor device that secures a medical instrument (such as a catheter or the like) in place relative to a skin penetration point using subcutaneous anchors.

Abstract: A catheter system and method of introducing an intravenous catheter into a patient includes a syringe, an access needle, a pliable catheter, and a guidewire. The syringe has a first chamber and a distal syringe end portion, which defines a conduit distally extending to a distal syringe opening such that the conduit fluidly connects the first chamber to the distal syringe opening. The access needle defines a needle lumen longitudinally extending therethrough and is secured relative to the distal syringe end portion. The pliable catheter is releasably secured relative to the access needle. The guidewire distally extends through the conduit toward the distal syringe opening and is configured to selectively move through the conduit, the distal syringe opening, and along the needle lumen to thereby guide movement of the pliable catheter relative to the access needle for introducing the pliable catheter into the patient.

Abstract: A guidewire for use in intravascular procedures has an inner coil that is radiopaque and an outer coil that is non-radiopaque at the distal end of the guidewire. The radiopaque inner coil is visible under fluoroscopy so that the physician can monitor the location of the distal end of the guidewire during a procedure. The inner coil and the outer coil can be formed from a single wire or a multi-filar wire. The inner coil and the outer coil can have any of the following cross-sections for enhanced torquability: I-beam; vertical rectangular; vertical ellipse; square; peanut shape; vertical hexagonal; horizontal hexagonal; and horizontal ellipse.

Abstract: A mold is used to form a solder joint to join the distal end of the guidewire to a wire coil. The mold has a cavity that can have different configurations so that the solder joint can be any of bullet shaped, micro-J shaped, cone shaped, truncated cone shaped, or have a textured surface.

Abstract: A medical device includes: a wire having a proximal end, a distal end, and a body extending between the proximal end and the distal end; and a coil disposed around a segment of the wire, wherein the coil comprises a proximal coil end, a distal coil end, and a coil body extending between the proximal coil end and the distal coil end; wherein the coil body comprises loops made from an elongated member having a cross-section, wherein the cross-section of the elongated member comprises a first side facing the wire, and a second side being opposite the first side and facing away from the wire; and wherein the second side of the cross-section of the elongated member has a higher curvature than the first side of the cross-section of the elongated member.

Abstract: A guide wire including a first core shaft made of a superelastic material, and a second core shaft made of a material more susceptible to plastic deformation than of the first core shaft and joined to a distal end side of the first core shaft on a proximal end side. On a joint part between the first core shaft and the second core shaft, the first core shaft and the second core shaft are adjacent to each other in a first direction. A flat portion where a length in the first direction in a transverse section is longer than a length in a second direction orthogonal to the first direction is formed on a distal end portion of the second core shaft.

Abstract: A guide wire including a first core shaft, a second core shaft, a covering member, and a joint layer. The first core shaft has a first large-diameter portion and a first small-diameter portion, and the second core shaft has a second large-diameter portion and a second small-diameter portion. The covering member covers a contact portion where the first and second small-diameter portions are arranged opposite to each other, and at least a part of each of the first and second small-diameter portions are adjacent to the contact portion. The joint layer joins the covering member with the first and second small-diameter portions inside the member. A length of the covering member is shorter than a sum of the lengths of the first and the second small-diameter portion in the axial direction, and longer than the shorter of the lengths of the first and second small-diameter portions in the axial direction.

Abstract: Embodiments of the present disclosure can include a system for steering a guidewire comprising: a guidewire tip integrably connected to a guidewire, the guidewire tip comprising a hollow body having first joint and second joints comprising a plurality of asymmetric recesses in the hollow body; a plurality of tendons operably connected to the first and second joints; and a control unit operably connected to the tendons and configured to actuate the tendons to provide multiple degrees of freedom of movement to the guidewire tip.

Abstract: A guide wire holder includes a sheath having a lumen, an operation wire which is inserted through the lumen to be able to advance and retract, and a hook which is continuous with a distal end of the operation wire and protrudes from a distal end of the sheath, wherein the sheath has an inner wall surface which forms a groove configured to extend from the distal end of the sheath to a proximal end side of the sheath, the groove has an opening portion which opens to an outer peripheral surface of the sheath, the hook has a guide wire engagement surface which is engageable with a guide wire, and the guide wire is able to be held between the guide wire engagement surface and the inner wall surface.