Abstract: Embodiments of the present disclosure provide an implantable device for monitoring properties of cerebrospinal fluid of a patient. In one embodiment, the device may include a housing, a processor, a support member, one or more sensors, and a data storage. The sensors may be in communication with the processor and configured to detect one or more properties of cerebrospinal fluid. The device may be configured for transmitting the data and receiving instructions by an operator for the delivery of a therapeutic agent or imaging agent from a reservoir disposed within the housing in operable communication with a pump.

Abstract: An optical coherence imager for use in a clinical environment includes a laser source (24) for illuminating an area of tissue surface and a detector array (28) arranged to generate output signals indicative of detected light scattered from the tissue surface. An optical coherence image, such as a Flux image that is indicative of blood perfusion in the tissue, is generated from data collected at the detector. Detector output is analysed to identify a time series of such optical coherence images during which relative movement between tissue and detector is favourable. A representative optical coherence image is formed from an average of optical coherence images generated from data collected within the identified time series and extending over a period of multiple heartbeats. The representative optical coherence image thereby exhibits minimal movement noise and the effects of heartbeat are averaged out.

Abstract: There is provided a scattered light signal measurement apparatus and an information processing apparatus that are capable of performing accurate measurement while preventing noise due to changes in relative velocity and relative position caused between a sensor and an observation target. The scattered light signal measurement apparatus includes a light receiving element and an incident angle limiting unit. The light receiving element receives scattered light obtained when coherent light emitted to a measurement target is scattered by the measurement target. The incident angle limiting unit limits an incident angle of the scattered light that is incident on a single point of the light receiving element to be equal to or smaller than a predetermined angle and controls the single light receiving element to increase an aperture ratio.

Abstract: A catheter, such as a fractional flow reserve catheter, includes an elongate shaft having a pressure sensing wire extending to the distal portion of the elongate shaft. The wire has a pressure sensor mounted on the distal end for measuring a pressure of a fluid within lumen of vessel. The pressure sensor wire is disposed within a pocket formed adjacent to the pressure sensor thereby minimizing the profile of the catheter. Bending stresses experienced by a pressure sensor mounted to a fractional flow reserve catheter when tracking the catheter through the vasculature creates a distortion of the sensor resulting in an incorrect pressure reading or bend error. In order to isolate the sensor from bending stresses, the sensor is spaced apart from the pressure sensor wire to allow the pressure sensor and the pressure sensor wire to move independently from one another.

Abstract: A blood pressure monitor that includes an acceleration sensor attached to an arm, which is a measurement site, of a measurement subject, and an orientation detection unit that detects an orientation of the measurement subject during blood pressure measurement based on an output of the acceleration sensor. The orientation detection unit specifies the orientation of the measurement subject in accordance with a torso angle with respect to a bed surface in a view along a body height direction of the measurement subject lying on the bed surface, and the orientation of the arm position. The blood pressure monitor also includes a blood pressure measurement unit that measures a blood pressure value at the measurement site of the measurement subject, and a blood pressure correction unit that corrects the blood pressure value of the measurement subject according to the specified orientation of the measurement subject.

Abstract: A wearable device for reflecting a fatigue level of a human body is disclosed. The device comprises a physiological signal acquisition module, a signal conditioning module, a parameter extraction module and a decision module. The physiological signal acquisition module is configured to acquire physiological signals of a testee. An output end of the physiological signal acquisition module is connected to an input end of the signal conditioning module. The signal conditioning module is configured to perform signal conditioning on the physiological signals. An output end of the signal conditioning module is connected to an input end of the parameter extraction module. The parameter extraction module is configured to extract time-domain and frequency-domain parameters in a specific time window. An output end of the parameter extraction module is connected to an input end of the decision module. The decision module is configured to decide a fatigue level of the testee.

Abstract: Provided are a pulse wave signal analyzer and an analysis method capable of determining a state of atrial fibrillation. The analyzer comprises a pulse wave detection unit for non-invasively detecting a pulse wave signal according to heartbeat of a living body; a spectrum generation unit for generating a frequency spectrum by Fourier transforming signal detected by the pulse wave detection unit; and an atrial fibrillation detection unit for detecting a state of atrial fibrillation based on the frequency spectrum generated by the spectrum generation unit. The spectrum generation unit repeatedly performs Fourier transform of the pulse wave signal at a predetermined time frame while shifting the time frame in a range of 0.005 to 0.02 seconds. The analyzer further comprises a filter for filtering the signal detected by the pulse wave detection unit, and the spectrum generation unit generates the frequency spectrum from signal output from the filter.

Abstract: The present application discloses a PPG circuit, a biological characteristics detection device and a biological characteristics detection method. The PPG circuit is configured to control a light source and N photoelectric converters to sense biological characteristics of an object under test; the PPG circuit includes: a transmitting channel, K receiving channels, wherein the N photoelectric converters are divided into K sets of photoelectric converter sets, and the K receiving channels respectively correspond to K sets of photoelectric converter sets; and a controller, configured to control the PPG circuit to operate in a partial sampling phase or an full sampling phase, so as to generates J or K biological characteristics sampling results during each of the pulse repetition cycles.

Abstract: A biometric data measurement device includes a light radiation unit configured to radiate green light having a full width at half maximum (FWHM) greater than or equal to 50 nm to a human body of a user; a light receiver configured to receive light reflected from or transmitted through the human body after being radiated from the light radiation unit; and a controller configured to calculate biometric data of the user using the received light wherein a lower wavelength limit of the FWHM is less than 500 nm, and an upper wavelength limit of the FWHM is greater than 520 nm.

Abstract: Methods and apparatus for monitoring a subject are described. A monitoring device configured to be attached to a body of a subject includes a sensor that is configured to detect and/or measure physiological information from the subject and at least one motion sensor configured to detect and/or measure subject motion information. The physiological sensor and motion sensor are in communication with a processor that is configured to receive and analyze signals produced by the physiological sensor and motion sensor. The processor is configured to process motion sensor signals to identify an activity characteristic of the subject.

Abstract: An information processing device in a biometric data measurement system according to a first embodiment of the present invention includes a communication unit, a display unit including a display screen, a connection unit connecting to the biometric data measurement device, an operation unit receiving a start operation for a measurement operation for biometric data, and a control unit transmitting a measurement start command for starting measurement of the biometric data, to the biometric data measurement device via the connection unit when a measurement start condition is satisfied after the operation section receives the start operation, and the measurement start condition includes prevention of the subject from viewing a display content of the display screen.

Abstract: An electrode includes a living body contact portion that is to be in contact with a living body and that contains a rubber material and at least one carbon material selected from carbon nanotubes and graphene. The ratio of the volume resistivity of the living body contact portion to the surface resistivity of the living body contact portion is 1.2 or more. The amount of the carbon material in the living body contact portion is 3 parts by mass or more and 20 parts by mass or less relative to 100 parts by mass of the rubber material, or the living body contact portion has a 25% compression hardness of 20 kPa or more and 110 kPa or less.

Abstract: A system response of an individual listener's brain to a sound signal stimulus is estimated. The system response represents the generation of an electroencephalography signal measured at a given measuring point of the listener's head by the sound signal stimulus. A sound signal with the sound signal stimulus is presented to the ear of the listener. An audio signal corresponding to the sound signal is generated, and audio signal data is extracted from the audio signal with a measuring electrode that measures an electroencephalography training signal. A measurement data set is generated from the first electroencephalography training signal. A noise signal is measured on the listener's head while the first sound signal impinges on the listener's ear. A Gaussian conditional probability density function taken as the system response of the listener's brain to the sound signal stimulus, with respect to the given measurement point.

Abstract: A component concentration measuring apparatus includes: a dielectric spectroscopy portion that irradiates a measurement subject with electromagnetic waves, thereby acquiring a complex permittivity spectrum; a signal processing portion that standardizes an imaginary part or an imaginary part spectrum of a complex permittivity at a frequency other than a frequency of an isosbestic point of the measurement subject, using an imaginary part of a complex permittivity at the frequency of the isosbestic point, out of the complex permittivity spectrum; and a calculating portion that applies a calibration model generated in advance from an imaginary part or an imaginary part spectrum of a complex permittivity of a sample whose component concentration is known, to the imaginary part or the imaginary part spectrum of the complex permittivity standardized by the signal processing portion, thereby calculating a component concentration of the measurement subject.

Abstract: A magnetic field measuring apparatus is provided including: a magnetic sensor array configured so that a plurality of magnetic sensor cells including a plurality of magnetic sensors each having a magnetoresistive element and magnetic flux concentrators arranged on both ends of the magnetoresistive element are three-dimensionally arranged and capable of detecting a magnetic field in three axial directions; a magnetic field acquiring section configured to acquire measurement data measured by the magnetic sensor array; and a signal space separating section configured to perform signal separation on a spatial distribution of a magnetic field indicated by the measurement data, based on basis vectors calculated from orthonormal functions and a position and magnetic sensitivity of each magnetic sensor of the magnetic sensor array.

Abstract: A bioimpedance-measuring device comprising a band configured so as to surround a wrist of a first arm of a user and on which there are arranged at least two current-injecting electrodes and at least two potential-measuring electrodes, said measuring device furthermore comprising a system for collecting raw bioimpedance data from the potential-measuring electrodes and a system for processing raw data in order to obtain at least one monitoring measurement and information signifying a pulmonary bioimpedance condition, said collection system being carried by the band and configured so as to communicate with the processing system.

Abstract: A method includes acquiring initial scout images of a patient's heart, using a neural network to establish a patient specific heart model, and automatically plan imaging planes of the patient specific heart model, performing an accelerated scan of the patient's heart, using the neural network to determine a current location and pose of the patient's heart from the accelerated scan, and to reposition the imaging planes to correspond to the current location and pose of the patient's heart, and using the repositioned imaging planes to perform an acquisition scan and generate an image of the patient's heart from the acquisition scan according to a selected imaging protocol.

Abstract: A mobile touchable system for user fitness and health monitoring is presented. The system is designed in one form as a mobile phone case and in another form as integrated in a mobile phone. It encompasses a series of measurement devices, including, but not limited to, arrays of electrodes for bio-impedance analysis, impedance tomography, and electrocardiographs, near-infrared spectroscopy for glucose level measurement, and heart rate monitoring. The touchable system performs incidental measurement in the background each time the user holds the mobile phone and hence enables long term health monitoring without user intervention. The touchable monitoring system further performs targeted spot measurements by following defined procedures. Spot measurement is enhanced through an extension measurement cable. Furthermore, an extension strap along with the mobile touchable system provides detailed activity tracking.

Abstract: A method of modeling lung movement includes acquiring images of a patient's lungs during the patient's breathing cycle, detecting an electromagnetic field with a plurality of sensors attached to the patient, determining location data from signals received from the plurality of sensors, and modeling the patient's lung movements based on the determined location data.

Abstract: A positioning method for a swallowable device is provided for positioning the in vivo swallowable device. The method includes: entering the m-th positioning period, m?1; energizing p electromagnetic coils simultaneously or sequentially, p?2; obtaining the actual magnetic field information Bwt sensed by the swallowable device each time the electromagnetic coils under energized, 1?t?p; calculating the individual magnetic field information Bi at the swallowable device when the electromagnetic coils are separately energized, 1?i?p; detecting the pitch angle and roll angle of the swallowable device in the m-th positioning period; calculating the yaw angle and spatial coordinates of the swallowable device in the m-th positioning period according to the pitch angle and roll angle and the individual magnetic field information Bi.

Abstract: A method, including receiving sets of signals during multiple cardiac cycles, each set indicating, for a probe inserted into a cardiac chamber, a 3D location of a distal end of the probe, electrical potentials measured at the location, and respective times during a given cycle when the potentials were measured. The received measurements and the respective times are compared to a first template for a sinus rhythm cycle and a second template for a non-sinus rhythm cycle so as to identify a sequence of cycles including consecutive first, second, and third cycles wherein the first and second cycles match the first template and the third cycle matches the second template. A physical map is generated based on the locations. Based on the received locations and corresponding potentials, an electroanatomic map including the local activation times for the non-sinus rhythm cycle overlaid on the physical map is rendered to a display.

Abstract: The embodiments described herein relate to devices, systems and methods for in-vivo diagnosis of disease-state tissue within a body.

Abstract: An acoustic system can track gas emissions by exploiting the nostril-accessible nasal pathways of an animal. Actuators and microphones used in the apparatus can be similar to those currently found in cell phones, which in turn make the acoustic apparatus small and rugged. The nostril geometry can be mapped using sound waves, similar to the mapping done by an acoustic rhinometer. Where acoustic rhinometers assume a constant speed of sound to measure changes in geometry, acoustic approaches as disclosed herein can assume constant geometry to measure changes in the speed of sound. Approaches disclosed here are particularly useful with any gas, such as (for example) methane, hydrogen, helium, etc. that has a speed of sound higher than other typical gaseous components of exhaled air, such as nitrogen, carbon-dioxide, oxygen, etc.

Abstract: A method for analyzing gait of a user includes: detecting, by left and right motion sensors respectively mounted on left and right shoes, movement of the left and right shoes so as to generate and output left-foot motion information and right-foot motion information; and by a processing unit, performing gait analysis based on plural sets of coordinates in a Cartesian coordinate system that are contained in the left-foot motion information and the right-foot motion information so as to generate a result of the gait analysis.

Abstract: Methods and/or systems for diagnosing, monitoring and/or treating persons at risk for falling and/or other pathological conditions. In an exemplary embodiment of the invention, people are diagnosed before they actually start falling. Optionally, the diagnosis includes trying out and identifying one or more fall triggers using virtual reality tools. Optionally or alternatively, treatment includes training the persons using situations and/or triggers which are determined to be relevant for that person.

Abstract: A method and system for determining a recommended level of exertion of an individual. A pollution level is identified and used to recommend a level of exertion that takes into account an amount of pollution inhaled by the individual.

Abstract: An apparatus for estimating a biological substance in a user using a unit spectrum for the biological substance acquired using a biological tissue simulation solution is provided. The apparatus may include a spectrometer configured to emit a light to a skin of a user, detect the light returned from the skin, and measure a skin spectrum of the user from the detected light and a processor configured to estimate a biological substance in the user based on the measured skin spectrum and a unit spectrum acquired using a biological tissue simulation solution.

Abstract: In an embodiment a portable electronic device includes a sensor device including at least one light emitter, at least one light detector, a housing in which the at least one light emitter and the at least one light detector are arranged and at least one channel forming a passageway through the housing, wherein the at least one light emitter and the at least one light detector are arranged such that light emitted from the at least one light emitter passes through the at least one channel and is thereafter detected by the at least one light detector.

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Abstract: Conformable and wearable sensors with integrated on-chip gate for the detection of biomolecules, chemicals, and other substrates and applications thereof are provided. Biosensor chips can be built with In2O3 nanoribbon field-effect transistors. Biosensor chips can conform to features of a human body, enabling ability for individuals to wear a biosensor.

Abstract: Systems, methods and graphical user interfaces for visualizing analyte measurements using animation are presented. For instance, a system for continuously monitoring analyte concentration in a physiological fluid includes a sensor, a transmitter, at least one processor and a display. The display is for outputting a graphical user interface. The display is controlled by the at least one processor to display, using the graphical user interface, historical analyte concentration levels and a trend indication animation. The trend indication animation comprises at least one visual element configured by the at least one processor to have a periodic motion between a first position and a second position on the display in one of a plurality of trend directions. The trend direction of the periodic motion between the first and second positions indicates whether the analyte concentration is increasing or decreasing and the rate of change of the analyte concentration level.

Abstract: A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

Abstract: Generally, methods of analyte monitoring management, and articles of manufacturing related thereto, are provided. The methods include receiving analyte measurement data and analyzing the analyte measurement data for health related parameters. Recommendations are determined for creating or modifying a treatment program based on the analysis, and provided within a user-interface that enables a user to create or modify the treatment program. Further, generally, methods of for managing analyte measurement data, and articles of manufacturing related thereto, are provided. The methods include receiving analyte measurement data that represent data collected over a time period, and analyzing the analyte measurement data for analyte episodes within that time period. Threshold based episodes and/or rate-of-change based episodes may be determined.

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration.

Abstract: In accordance with one embodiment of the invention, a system is provided for the monitoring of blood analytes using optical probes in the circulatory system. The probes can be inserted on the venous side of the circulatory system. In another embodiment, methods and apparatuses can be used for processing continuous information generated from indwelling intravascular or tissue optical sensors including, but not limited to, measuring gas concentrations, pH, temperature, and other analytes of blood or tissue. In another embodiment, analyte values can be displayed and analyzed to determine if the values fall outside of normal physiological parameters. Trends of one or multiple analyte values can be analyzed and extrapolated to predict any impending, deleterious condition. In one embodiment, an alarm can be transmitted to appropriate personnel when criterion/criteria are met. In yet another embodiment, devices can be inhibited from delivering continuous infusions of medicine to patients.

Abstract: Health and care are improved through monitoring health markers. In one example a method includes measuring repeatedly at different times a quantity of a biochemical marker in a patient, storing the measurements in a log as entries associated with the patient, analyzing the stored measurements by comparing the quantity of the marker across the plurality of log entries, and determining an illness condition when a recent entry is different from previous log entries, for example when the recent entry is different by more than a threshold or when a baseline level or regular pattern is established from the multiple stored measurements and the recent entry is a change from the baseline by more than a threshold. If a deviation is determined, then an alert condition regarding the patient is determined.

Abstract: A device for obtaining physiological information of a medical patient and wirelessly transmitting the obtained physiological information to a wireless receiver.

Abstract: A method for determining oxygen saturation includes emitting light from sources into tissue; detecting the light by detectors subsequent to reflection; and generating reflectance data based on detecting the light. The method includes determining a first subset of simulated reflectance curves from a set of simulated reflectance curves stored in a tissue oximetry device for a coarse grid; and fitting the reflectance data points to the first subset of simulated reflectance curves to determine a closest fitting one of the simulated reflectance curves. The method includes determining a second subset of simulated reflectance curves for a fine grid based on the closest fitting one of the simulated reflectance curves; determining a peak of absorption and reflection coefficients from the fine grid; and determining an absorption and a reflectance coefficient for the reflectance data points by performing a weighted average of the absorption coefficients and reflection coefficients from the peak.

Abstract: This relates to an electronic device configured for optical sensing having shared windows and including light restriction designs. The light restriction designs can include one or more of optical layers, optical films, lenses, and window systems configured to reduce or eliminate crosstalk between optical components. A plurality of accepting sections and a plurality of blocking sections can be employed to selectively allow light having an angle of incidence within one or more acceptance viewing angles and block light with angles of incidence outside of the acceptance viewing angles. In some examples, the light restriction designs can include variations in optical and structural properties can allow the light restriction designs to have spatially varying acceptance angles. Variations in structural properties can include, but are not limited to, differences in widths, heights, and/or tilts of the accepting sections and/or blocking sections.

Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices. Embodiments include removing a substantially cylindrical cap from an inserter to expose a substantially cylindrical sleeve, removing a cover from a substantially cylindrical container holding sensor components, and fitting the sensor components into the inserter.

Abstract: A biological fluid collection system that includes a power source for a collection module that receives a sample and provides flow-through blood stabilization technology and a precise sample dispensing function for point-of-care and near patient testing applications is disclosed.

Abstract: A lancing device for infant with safety rotating and unlocking push-shooting button is provided. The push-shooting button is exposed and occupies two position attitudes. A first attitude is an insurance lock-out state that the push-shooting button is locked to avoid an undesired trigger before actuation, and a second attitude is a state that leaves away from the first one attitude where the push-shooting button is readily loaded to be launched. Under the insurance lock-out state, the push-shooting button is locked and moves only by a rotation. Firstly, the button is rotated and loaded to a to-be-launch state. Then, the button is pressed inwards and an edge lancing mechanism is actuated with a blade projecting from a lancing opening of the shell to cut and retract back into the shell. The whole blood collecting procedure is finished.

Abstract: A blood separation device that decouples and separates the blood collection process from the plasma separation process is disclosed. The blood separation device includes a sample collection module, an activation module, and a separation module. Because the plasma separation happens after the blood separation device is disconnected from a patient, the device performance is no longer affected by patient blood pressure and needle gauge, and patient discomfort is greatly reduced.

Abstract: A method capturing eye movement data for detection of cognitive anomalies, includes a computer application displaying a frame on a display, capturing and displaying a video image of a user's face and eyes, while the user aligns the face to the frame, capturing and processing the face image to initiate an image eye movement capture process, outputting an indication on a display and moving the indication spatially to one of a plurality of images, capturing a video of each user eye, to track the position of the indication of the display, the image of each eye comprising a sclera portion, an iris portion, and a pupil portion, parsing the video to determine a reference images corresponding to eye positions, capturing the user's eyes while the user views familiar and novel images, and correlating the images of the user's eyes to the familiar or novel images using the reference images.

Abstract: A method for determining a state of mind of a user may include receiving one or more strings of characters composed by the user, and determining, by a processing device, the state of mind of the user by processing the one or more strings of characters. The processing of the one or more strings of characters may include identifying similarities of the one or more strings of characters with other strings of characters indicative of the state of mind. The method may also include determining, based on the one or more strings of characters, a severity of the state of mind of the user.

Abstract: A system for assigning a social attribute class to a human subject in a predefined closed environment includes an image capturing component, a pose detection component configured to perform pose detection and tracking of a human subject in real-time, an action detection component configured to detect an action of the human subject, an activity detection component configured to relate a sequence of actions to detect an activity of the human subject, and a social attribute classification component. The social attribute classification component is configured to determine an average speed (s) of the human subject as a first social attribute, an interaction time of the human subject (Tint) as a second social attribute, an analysis time (Tanal) as a third social attribute, and automatically assigns a social attribute class to the human subject based on the values of the first, second and third social attributes.

Abstract: A wireless cardiac sensor is provided. The sensor may be utilized by a patient, on themselves, in an at home or other non-clinical environment. A sensor housing contains ECG electrodes and an audio transducer to simultaneously capture heart sound and ECG data with a single device. The ECG electrodes may be positioned on opposite sides of, and preferably adjacent to, an audio transducer sensor, for placement against a user's chest. The wireless cardiac sensor may include a button on a surface opposite the ECG electrodes and audio sensor, facilitating one-handed operation by a patient. The sensor transmits acquired data to a personal electronic device, such as a smartphone, via a wireless communication link. The personal electronic device may in turn transmit data to a centralized server and/or health care provider devices, via a wide area network.

Abstract: The present invention relates to a method, device, and system for improved mapping and/or ablation of a tissue. The device may generally include an elongate body and a distal assembly affixed to the elongate body that includes a treatment electrode having a conductive mapping region and a selectively conductive ablation region that is conductive of high-frequency current and substantially non-conductive of low-frequency current. Alternatively, the device may generally include a treatment electrode having a conductive mapping or ablation region and a region that is coated with an electrically insulated but thermally conductive layer.

Abstract: A method for sampling biometric data, a sampling and managing apparatus thereof, an apparatus for detecting biometric data, and an electronic device are provided. The method for sampling biometric data includes: determining, based on a preset sampling rule, a sampling configuration corresponding to a sampling time slot in a sampling refresh period, the sampling refresh period including a plurality of the sampling time slots; and controlling, based on the sampling configuration corresponding to the sampling time slot in the sampling refresh period, a sampling channel corresponding to the sampling time slot to sample a target signal to obtain sample data associated with the biometric data, thereby improving the flexibility in sampling process control.

Abstract: Provided are a fetal electrocardiographic signal processing method and a fetal electrocardiographic signal processing device that can appropriately select a signal reliably including a fetal electrocardiographic component from a plurality of signals separated by independent component analysis with reference.