Abstract: Fetal tissue oxygenation may be performed transabdominally by, for example, receiving a plurality of detected electronic signals that correspond to light emitted from a pregnant mammal's abdomen and a fetus contained therein that has been detected by the detector and converted into the detected electronic signal. An indication of a depth of the fetus within the pregnant mammal's abdomen may be received and a portion of the detected electronic signals that correspond to light that was incident upon the fetus may be isolated responsively to the indication of the depth of the fetus using, for example, time of flight of photons that correspond to the detected electronic signals. A fetal tissue oxygen saturation level may then be determined using the isolated portion of the detected electronic signals that correspond to light that was incident upon the fetus.

Abstract: An enzymatic sensor configured to determine the concentration of levodopa present in a sample according to a current or a resonant frequency produced in response to levodopa interactions with L-amino acid decarboxylase present in the sensor. A processor associated with the sensor determines levodopa concentration and produces dose recommendation or output according to levodopa concentration.

Abstract: Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously.

Abstract: A capsule (220), said capsule (220) having a coupling face (222) configured to be coupled to a complementary shape on a housing (120), and a microneedle array (210) that is positioned on a planar contact surface (229). The coupling face (222) has rotational symmetry about an axis of rotation (Z) which extends orthogonally to the planar surface (229) and about which at least two coupling positions are permitted with a single and unique complementary shape on a housing (120), there being, within a fixed reference frame, no microneedle (210) in the same location as that of a different microneedle (210), in the two positions.

Abstract: Glucose monitoring based on fluorescence sensor disclosed. A glucose monitoring apparatus according to one embodiment of the present invention may include a light emitter configured to emit an excitation light, a glucose sensor configured to absorb the excitation light and to emit a fluorescent light, a light receiver configured to receive the fluorescent light, and a circuit configured to modulate a scattered wave by using a series of pulses that are generated based on alight intensity of the fluorescent light.

Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.

Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes an array two or more discontiguous sensing elements deposited on a substrate surface, where the sensing elements comprise one or more droplets of a sensing element formulation.

Abstract: The present invention relates generally to systems and methods for processing, transmitting, and displaying data received from continuous analyte sensor, such as a glucose sensor. In some embodiments, the continuous analyte sensor system comprises a sensor electronics module that includes power saving features. One feature includes a low power measurement circuit that can be switched between a measurement mode and a low power mode, in which charging circuitry continues to apply power to electrodes of a sensor during the low power mode. In addition, the sensor electronics module can be switched between in a low power storage mode higher power operational mode via a switch. The switch can include a reed switch or optical switch, for example. A validation routine can also be implemented to ensure an interrupt signal sent from the switch is valid.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Abstract: An apparatus and computerized method of determining a current hemoglobin level comprising providing a computing device having an input/output interface, one or more processors and a memory, receiving a series of hemoglobin measurements taken within a time window, determining a current hemoglobin level based on the series of hemoglobin measurements using a linear regression model, and providing the current hemoglobin level via the input/output interface.

Abstract: A system SY for determining a tissue type TY of a tissue region TR is provided in which the distal ends OFDE1 . . . n of at least three optical fibers define a plurality of intersecting optical paths IOP1 . . . k within the tissue region TR. A tissue signal Q1 . . . k indicative of a tissue type TY for the respective optical path IOP1 . . . k is generated from said spectral measurement data SMD corresponding to each of the plurality of intersecting optical paths IOP1 . . . k. Each tissue signal Q1 . . . k is compared with a reference threshold QRT for the tissue type, and with an average of the tissue signals QMA. At least a portion of the tissue region is identified as the tissue type TY if i) every tissue signal Q1 . . . k in the tissue region TR indicates that its corresponding tissue is not the tissue type TY in the comparison with the N reference threshold QRT and ii) at least one of the tissue signals Q1 . . . k in the tissue region TR lies between the average QMA of the tissue signals Q1 . . .

Abstract: A system and method to help maintain quality control and reduce cannibalization of accessories and attached probes in a highly sensitive patient monitor, such as a pulse oximetry system. One or more attached components may have information elements designed to designate what quality control mechanisms a patient monitor should look to find on that or another component or designate other components with which the one component may properly work. In a further embodiment, such information elements may also include data indicating the appropriate life of the component.

Abstract: Embodiments of the disclosure provide an oximeter, including a blood oxygen collecting unit that has a first light emitting unit, a second light emitting unit, and a light receiving sensor, the first light emitting unit emitting a red light, the second light emitting unit emitting an infrared light, and the light receiving sensor receiving the red light emitted by the first light emitting unit and the infrared light emitted by the second light emitting unit and not absorbed by the human body, and converting them into an electrical signal, a storage unit that stores a first threshold value, a microprocessor that calculates a blood oxygen saturation of the human body based on the electrical signal detected by the light receiving sensor, and includes a judging unit that judges whether the blood oxygen saturation is lower than the first threshold value, and a display unit.

Abstract: A first medical device can acquire a physiological parameter value from a patient and communicate the physiological parameter value to a medical network interface. The medical network interface can link a patient ID associated with the physiological parameter and a device ID associated with the first medical device with the medical network interface's device ID. The medical network interface can pass the physiological parameter value to a second medical device for further processing or routing to another medical device.

Abstract: Apparatuses and methods for dried blood spot (DBS) sample collection are disclosed. A dried blood spot sampling device is configured to deliver blood through a passage to an absorbent disk in the device and control an amount of blood saturating the absorbent disk. The sampling device may include a manually actuatable component adjustable between a first position, in which an outlet of the passage is not in physical contact with the absorbent disk, and a second position, in which the outlet of the passage is in physical contact with the absorbent disk.

Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

Abstract: Described and illustrated herein are methods and systems for the use of physiological data relating to cognitive state of a user, recorded from one or more sensors, for analyzing and reporting assessments of the cognitive state of the user.

Abstract: A mental state awareness system comprises a non-invasive brain interface assembly configured for detecting brain activity of a user, a processor configured for determining a mental state of a user based on the detected brain activity, and a biofeedback device configured for automatically providing biofeedback to the user indicative of the determined mental state of the user.

Abstract: A system, devices, and methods are described for imaging and measuring the mechanical properties of both surface and subcutaneous tissues found in living organisms, animals, and in natural and synthetic materials, and may include a first device configured to determine a modulus of a portion of bulk material or subcutaneous tissue (via measurement of vibrations), and/or determine resonant frequency of the vibrations, and a second device operably connected to the first device and configured to generate vibrations. The first device may be an optical coherence tomography device. The system may include a processor and data storage device with instructions which when executed by the processor, cause the processor to process of the frequency data and the displacement data to determine a resonant frequency of the material under investigation and calculate the mechanical modulus of elasticity of the material from a resonance frequency spectrum of the analyzed spectral image.

Abstract: A method of monitoring user effectiveness during cyclic operation of an exercise machine (10) having a pair of human limb-operable drive members (31,32) coupled for cyclic movement.

Abstract: An organ evaluation device, system, or method is configured to receive electrophysiological data from a patient or model organism and integrates the data in a computational backend environment with anatomical data input from an external source, spanning a plurality of file formats, where the input parameters are combined to visualize and output current density and/or current flow activity having ampere-based units displayed in the spatial context of heart or other organ anatomy.

Abstract: Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.

Abstract: A measurement device includes a biosensor that acquires biological information, a pressing force detection component that detects a pressing force produced when the biosensor makes contact with a part of a living body to be measured, and a processor that converts the biological information to a first measurement value, calculates a second measurement value by correcting the first measurement value based on the pressing force, and outputs the second measurement value.

Abstract: A battery-less heartbeat monitoring system that operates continuously using energy harvested from a low-grade heat source or small thermal gradient, such as human body heat and the gradient that exists between skin and the ambient environment in most circumstances.

Abstract: A three-dimensional model of the patients body surface of 360 degrees with the coordinates of ECG electrodes is formed via a computer program according to data of three-dimensional photo-scanning of the patients body surface from above and data of three-dimensional photo-scanning of the patients back imprint. Position of ECG electrodes on the body surface relative to the surface of the heart is determined via computer simulation and combining a three-dimensional model of the body surface of 360 degrees, obtained during three-dimensional photo-scanning, and a three-dimensional model of the heart and the inner surface of the chest, obtained during CT or MRI procedure.

Abstract: A processing method using an electrocardiogram signal includes (a) selecting a candidate for an abnormal R-peak from the electrocardiogram signal, (b) determining an abnormal R-peak from among the candidates selected in (a), and (c) excluding the abnormal R-peak determined in (b) among all the R-peaks from the electrocardiogram signal.

Abstract: A medical device is configured to sense an electrical signal and determine that signal to noise criteria are met based on electrical signal segments stored in response to sensed electrophysiological events. The medical device is configured to determine an increased gain signal segment from one of the stored electrical signal segments in response to determining that the signal to noise criteria are met. The medical device determines a noise metric from the increased gain signal segment. The stored electrical signal segment associated with the increased gain signal segment may be classified as a noise segment in response to the noise metric meeting noise detection criteria.

Abstract: In accordance with an aspect of the present invention, a system and method allows for the assessment of health and mortality based on dynamic nonlinear calculations of self-similar fluctuation patterns in a time series of QT intervals and of other physiological signals, such as RR intervals, temperature, blood pressure, respiration, saturation of peripheral oxygen, intracardiac pressures, and electroencephalogram. In order to nonlinearly determine health and mortality, time series of QT intervals and of other physiological signals (e.g., RR intervals) are simultaneously obtained, and entropy values are calculated for each signal over the same temporal interval. “EntropyX” is calculated from relative changes between moments and entropy of QT intervals and those of other physiological signals over seconds to days. The absolute and relative entropy values at a specific time point and/or subsequent changes in entropy over future time points can be used to determine a treatment plan for the subject.

Abstract: The adoption of His Bundle Pacing (HBP) has been hindered by the procedural difficulty of achieving good lead position without causing cardiac damage or perforation. The procedural success rates are much lower when compared to traditional right ventricle (RV) pacing procedures due to the difficulty in mapping the His potential with the exposed helix and maintaining position while the pacing helix is fixated. The use of multidirectional balloon tipped catheter system that includes a catheter body with curls and flexion points and anchor balloon mounted to a distal end of the catheter body increases positional precision and an improved procedural success rate when compared to the conventional system.

Abstract: The invention presented personalized biofeedback computerized system, an End-to-End eHealth smart platform for analysis, diagnosis and therapy of types of behavioral disorders. The system comprises a Captive Portal (CP) data input for initial input data and for continuous input data, a database comprising data, a Computer Processing Manager (CPM) for processing the patient data and the database, a Graphical User Interface (GUI) for interfacing with a user, and an Electroencephalography (EEG) or hemoencephalography (HEG) cap for stimulating predetermined areas in the brain, wherein the CPM is interconnected to the CPP, the database and the GUI, the CPM provides instructions for cranial electrode mediated stimulation to the areas in the brain according to a predetermined patient data dependent protocol, and the database provides external data. A preferred embodiment of the invention is a multilayered bio-feedbacking system.

Abstract: A Brain-Computer Interface (BCI) based rehabilitation system and method is described in which an auditory or visual stimulus is provided to a user instructing them to imagine performing a physical action with a body part such as a hand during a trial period. A BCI processes the electroencephalography (EEG) signals to perform feature extraction and then feature translation (classification) to determine if the user intended to perform the action. If the intension was detected the body part is incrementally moved to provide proprioceptive feedback to the user. The feedback process is repeated at a Feedback Update Interval (FUI) of 100 ms or less. Preferably a reaction time test is used to determine the optimal FUI for an individual where shorter FUIs used for shorter reaction times. In one embodiment, if the user has slow reaction times, the FUI is initially between 100 ms and 1000 ms and gradually decreased over a series of sessions until the FUI is less than 100 ms.

Abstract: Disclosed is an instrument assembly for a selected procedure. The procedure may include a dissection and neural monitoring. The instrument may be insulated to allow for a selected and precise electrical conductive path.

Abstract: A system for performing surgical procedures and assessments. The system includes the use of neurophysiology-based monitoring to determine nerve proximity and nerve direction to surgical instruments employed in accessing a surgical target site.

Abstract: A computer implemented method is disclosed for detecting a mild traumatic brain injury (mTBI) on a subject having recently suffered a head injury. The method includes (1) receiving first electrocardiogram (ECG) data from the subject during a first transition from a first position to a second position; and (2) determining a probability value of mTBI within the subject based at least partially on the first ECG data during the first transition. The first position may be a prone position or a supine position and the second position may be a standing position.

Abstract: In various aspects and embodiments provided are compositions and methods for identifying patients in need of improving cognition and/or treating a neurodegenerative disease in a patient and treating such patient.

Abstract: A method of detecting a seizure includes collecting volatile organic compounds with a collector material of a collector; separating a mixture of the volatile organic compounds into its constituent chemicals with a gas chromatography column; ionizing the constituent chemicals to create ionized chemicals and detecting the ionized chemicals; and analyzing the ionized chemicals to identify seizure-indicative volatile organic compounds.

Abstract: We report a method of determining an occurrence of an epileptic convulsive seizure in a patient, comprising: receiving body data from a patient during a first time period, determining a work level relating to said first time period at least based partially upon said body data; determining whether said work level exceeds an extreme work level threshold; performing a responsive action, in response to a determination that said work level exceeds said extreme work level threshold. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

Abstract: A system for monitoring erectile dysfunction of a user includes a penile device configured to be accommodated on penis to evaluate penile tumescence, rigidity, and bio-impedance of penile shaft of the penis; and a head-band device implemented as a sleeping mask with electrodes strategically placed around the eyes of the user for detecting sleep characteristics, electrooculography (EOG), and electroencephalography (EEG). A computing device is operatively coupled to penile device and the head-band device to detect condition of rapid eye movement (REM) sleep phase and a condition of penile tumescence, and to actuate the penile devise to measure rigidity of the penile shaft to qualify condition of the erectile dysfunction as organic or inorganic.

Abstract: Kits, diagnostic systems and methods are provided, which measure the distribution of colors of skin features by comparison to calibrated colors which are co-imaged with the skin feature. The colors on the calibration template (calibrator) are selected to represent the expected range of feature colors under various illumination and capturing conditions. The calibrator may also comprise features with different forms and size for calibrating geometric parameters of the skin features in the captured images. Measurements may be enhanced by monitoring over time changes in the distribution of colors, by measuring two and three dimensional geometrical parameters of the skin feature and by associating the data with medical diagnostic parameters. Thus, simple means for skin diagnosis and monitoring are provided which simplify and improve current dermatologic diagnostic procedures.

Abstract: Many treatments of skin cancer need an accurate assessment of the margins of the tumor. Spectrally-encoded optical polarization imaging improves upon the demarcation of skin cancer such as keratinocytic carcinomas. When the clinician can outline the clinical boundary of each lesion, surgery and other treatments can be more efficient and effective. Optical images of the lesions are acquired at various wavelengths, then spectrally-encoded. Spectral-encoding of the images minimizes the impact of background pigmentation and vascularization so that the tumor can be accurately visualized.

Abstract: Data collection schemes for a wound dressing and related methods are disclosed. In an embodiment, a monitor device for a wound dressing system comprises a wound dressing. The wound dressing comprises an electrode assembly. The electrode assembly comprises a plurality of electrodes including a first set of first electrodes and a second set of second electrodes. The monitor device comprises: a processor, memory and a first interface. The first interface is connected to the processor and the memory. The first interface comprises a plurality of terminals including a first terminal and a second terminal and a data collector coupled to the first terminal and the second terminal.

Abstract: Knee joint laxity testing apparatus includes a thigh cradle assembly, a shank cradle assembly, and a heel cradle assembly. The apparatus is configured to measure knee laxity in three planes of motion: anterior-posterior translations; varus-valgus rotations; and internal-external rotations. The thigh cradle assembly, shank cradle assembly, and heel cradle assembly are mounted on a common base. A thigh fixation system is attached to the thigh cradle assembly both at the proximal and distal ends to firmly stabilize the thigh in the thigh cradle. The patella pad and distal thigh fixation system are mounted on a U-bar assembly. The distal thigh fixation system includes two condyle pad adjustment arms upon which a respective condyle pad is mounted, and a patella pad mounted to a linear track on an underside of the U-bar assembly.

Abstract: A device for liveness detection is disclosed. The liveness detecting device has a simplest structure that principally comprises a light sensing unit and a signal processing module. Particularly, the signal processing module is configured for having a physiological feature extracting unit and a liveness detecting unit therein. The physiological feature extracting unit is adopted for extracting a first physiological feature from a PPG signal, or extracting a second physiological feature from the PPG signal that has been applied with a signal process. As such, through the first and second physiological features, the liveness detecting unit is able to determine whether a subject is a living body or not. The liveness detecting device does not use any camera unit and iPPG technology, such that the liveness detecting device has advantages of simple structure, low cost and immediately completing liveness detection.

Abstract: Systems, devices, and methods for monitoring a person's sleep are described. Thermal images of a person sleeping can be captured using an infrared camera and processed to determine the body temperature of the person. A particular sleep stage and its duration can be determined using the body temperature. In addition, the data obtained from monitoring the person can be used to determine if the person is suffering from one or more sleep disorders or other health problems. In this manner, a person's sleep quantity and quality can be determined in a non-invasive, efficient, and comfortable manner.

Abstract: A method of determining touch sensitivity threshold at a region of body of a human using a probe. The method includes setting first value for impact attribute of probe; releasing the probe towards the region, to impact the region with the first value for impact attribute; receiving first feedback from human in response to the impact of the probe with the first value for the impact attribute. The method further includes changing the first value of the impact attribute to set a second value; releasing the probe towards the region, to impact the region with the second value for the impact attribute; receiving a second feedback corresponding to the second value for the impact attribute. The method includes changing value of impact attribute until determination of touch sensitivity threshold as either a lowest value of sensing or a highest value of senselessness of probe based on the feedback.

Abstract: Disclosed is a surgical video creation system, comprising: a surgical microscope comprising a light source; an image processing device configured so as to create a 3D video of surgical scenes and fluorescent images by means of the surgical scenes using the microscope; an optical adapter provided so that the image processing unit is mounted on the microscope; and a display unit configured so as to display the 3D video, wherein the image processing unit is configured so as to recognize the boundary of tumorous tissue by means of the fluorescent images and display the boundary in the 3D video, and the fluorescent images are created by light emitted from a fluorescent material which is selectively accumulated only in the tumor.

Abstract: The present invention relates to a system (100) for monitoring one or more physiological parameters of an individual. The system (100) comprises an optical fibre assembly (110) configured to measure one or more physiological parameters of an individual, and a pressure sensor (120) configured to measure a contact pressure of the optical fibre assembly (110) on the individual. The pressure sensor (120) comprises an optical fibre (122) comprising a transducer fibre Bragg grating (127) embedded in a matrix (121). The matrix (121) is configured to cause longitudinal strain in the transducer fibre Bragg grating (127) in response to the matrix (121) being subject to a transverse load. The one or more physiological parameters that the system (100) is for monitoring may include blood oxygen saturation (Sp O2), capillary refill time (CRT), heart rate, blood flow and CO2 emissions from skin.

Abstract: The wearable data collection device includes a processor, a sensor, a digital memory storage, and a battery. There can also be a data transmitter, a data transceiver, and a plurality of switches. The processor, sensor, digital memory storage, and any other electronics can be housed within a sensor module, while the battery is housed within a battery module. The modules are joined to one another to define a sealed unit to be fit in a housing. The housing can be attached by a strap to the user. The switches isolate the battery from the sensor, digital memory storage, the data transmitter, the data transceiver, or other electronic component.

Abstract: Presented are concepts for determining reliability of vital signs of a monitored subject. One such concept obtains activity data relating to detected activity or posture of the monitored subject. Based on the activity data and physiological data relating to one or more physical or physiological attributes of the monitored subject, a measure of reliability of vital signs of the monitored subject is determined.