Patents Issued in September 2, 2021
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Publication number: 20210267859Abstract: Photostabilizing compounds are provided. In particular, the photostabilizing compounds may be heterocyclic or homocyclic. Topical compositions comprising these compounds are also provided. In particular, these topical compositions may further comprise photoactive compounds. Methods for stabilizing photoactive compounds are also provided. These methods comprise mixing the photoactive compounds with photostabilizing compounds.Type: ApplicationFiled: June 13, 2019Publication date: September 2, 2021Inventor: Craig Alan Bonda
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Publication number: 20210267860Abstract: A hair-dyeing composition with an effect of minimizing hair damage and scalp irritation caused by ammonia prescription and ammonia odor, which is capable of decreasing ammonia odor peculiar to a hair-dyeing composition and also of supplementing the hair with amino acids similar to hair proteins to decrease hair damage, especially hair roughness and hair shortening, for healthy dyeing and a method of producing the same.Type: ApplicationFiled: July 2, 2019Publication date: September 2, 2021Inventors: Sergio Ricardo Justa, Simone Aparecida da França Stefoni, Jéssica Francischini Novais, Beatriz de Moura Abreu
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Publication number: 20210267861Abstract: A dye for hair coloration that has a long shelf life and is excellent in heat resistance, and a method for producing the dye for hair coloration, are provided. A dye for hair coloration represented by the following general formula (1), the dye for hair coloration having a proportion of a polyatomic anion (An) or impurities derived from An of 1% by mass or less: wherein in the formula (1), D represents a cationic moiety of the dye for hair coloration; An represents a polyatomic anion; and a and b each independently represent a value of 0 to 1.Type: ApplicationFiled: February 25, 2021Publication date: September 2, 2021Applicant: HODOGAYA CHEMICAL CO., LTD.Inventors: Keigo NAITO, Tetsuya YOSHIDA
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Publication number: 20210267862Abstract: An objective of the present invention is to provide a gel-type skin preparation for external use into which a di-chain cationic surfactant can be stably blended without precipitation over time and which can be spread topically on skin. The gel preparation according to the present invention comprises (a) a di-chain cationic surfactant having a specific structure, (b) an oil in which component (a) is soluble, (c) a lower alcohol, (d) a water-soluble thickener, and (e) water.Type: ApplicationFiled: July 8, 2019Publication date: September 2, 2021Applicant: Shiseido Company, Ltd.Inventors: Shoko ARINO, Yukiko HIRUMA
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Publication number: 20210267863Abstract: A personal care composition is provided, comprising: a vehicle; a cosmetically acceptable oil; and a cationic polymer comprising structural units of acrylamide monomer; structural units of N,N-dimethyl acrylamide monomer; and structural units of monoethylenically unsaturated monocationic monomer; wherein the cationic polymer comprises <10 mol % structural units of multiethylenically unsaturated cationic monomer; wherein the cationic polymer comprises <30 wt % structural units of ester containing monomers; wherein the cationic polymer comprises <1 mol % structural units of ethylenically unsaturated monomers containing a moiety selected from the group consisting of epoxy, anhydride, imide, lactone, carboxylic acid, sulfonic acid and isocyanate; wherein the cationic polymer comprises <0.1 mol % structural units of a reactive siloxane; and wherein the personal care composition comprises <0.05 wt % water soluble, organic, ampholytic polymer conditioning agent.Type: ApplicationFiled: August 22, 2019Publication date: September 2, 2021Inventors: Ying O'Connor, Fanwen Zeng, Lyndsay M. Leal, Peilin Yang, Asghar A. Peera, Sokhomari S. Suon, Inna Shulman
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Publication number: 20210267864Abstract: The present invention relates to a cooling composition for producing cooling particles comprising a solvent component and dissolved therein (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide. The present invention further relates to cooling particles comprising a cooling composition according to the invention, oral preparations comprising cooling particles, new uses of cooling particles, a process for the production of cooling particles as well as the use of a solvent component for dissolving cooling agents.Type: ApplicationFiled: July 6, 2018Publication date: September 2, 2021Inventors: Jenny WEISSBRODT, Michael BACKES, Rita LAGES, Olga PAULI
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Publication number: 20210267865Abstract: The present disclosure relates to a cosmetic composition for increasing skin exfoliation, which contains an exfoliating agent and contains no or 10 wt % or less of a polyol humectant based on the total weight of the composition. The composition of a cosmetic material is selected such that the affinity of the exfoliating agent to keratin-binding proteins can be retained and, thus, the provided exfoliation-increasing effect can be achieved reliably. Furthermore, the cosmetic material does not cause irritation and, in particular, can retain the superior exfoliating effect of serine or carnitine.Type: ApplicationFiled: June 5, 2019Publication date: September 2, 2021Applicant: LG HOUSEHOLD & HEALTH CARE LTD.Inventors: Byung-Jun AHN, Nae-Gyu KANG, Jin-Hyun KIM
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Publication number: 20210267866Abstract: The present invention relates to a cosmetic composition comprising anionic surfactants of polyoxyalkylenated alkyl(amido)ether carboxylic acid type, additional non-sulfated anionic surfactants, non-ionic and amphoteric surfactants and cationic or amphoteric polymers. The invention also relates to a process for the cosmetic treatment of keratin materials, in particular for washing and/or conditioning the hair, using such a composition, and also to a use employing said composition.Type: ApplicationFiled: June 19, 2019Publication date: September 2, 2021Inventors: Virginie LE CHAUX, Saber MALOUG, Estelle MATHONNEAU
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Publication number: 20210267867Abstract: Hair cleansing compositions and methods of use thereof. The hair cleansing composition comprising: (a) about 10 to about 20 wt. % of an sulfate based anionic surfactant; (b) about 1 to about 4 wt. % of amphoteric surfactant; (c) about 4 to about 10 wt. % of a plurality of nonionic surfactants, the plurality of nonionic surfactants comprising: (i) about 1 to about 1.5 wt. % of fatty alcohols, (ii) about 1.5 to about 3 wt. % of glucamide, and (iii) about 1.5 to about 5.5 wt. % of alkanolamide, (d) about 0.5 to 2.5 wt. % of an oil, wherein the oil is a non-silicone oil; and (e) water, wherein all weight percentages are based on the total weight of the hair cleansing composition.Type: ApplicationFiled: February 28, 2020Publication date: September 2, 2021Inventors: Angela PARK, Pedro APRIGLIANO
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Publication number: 20210267868Abstract: Disclosed are conditioning systems comprising (a) at least one anionic surfactant chosen from isethionate surfactants; (b) coco-caprylate/caprate; and (c) at least one cationic compound, and rinse-off compositions comprising (a) an anionic surfactant system comprising i) a first anionic surfactant chosen from isethionate surfactants, and ii) optionally, a second anionic surfactant; (b) coco-caprylate/caprate; and (c) at least one cationic compound. Also disclosed are methods of treating and/or caring for the skin, hair, and/or scalp with the conditioning systems and/or rinse-off compositions containing the conditioning systems.Type: ApplicationFiled: February 29, 2020Publication date: September 2, 2021Inventors: Liliana XAVIER, Anna BOTTO
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Publication number: 20210267869Abstract: Hair cleansing agents containing the following components (A) to (E) and water: (A) not less than 3 wt % and not more than 12 wt % of one or more kinds selected from the group consisting of acyl isethionate and ?-olefin sulfonate (B) not less than 0.5 wt % and not more than 10 wt % of acyl acidic amino acid or a salt thereof, (C) not less than 0.005 wt % and not more than 0.8 wt % of a cationic polymer, (D) not less than 0.25 wt % and not more than 3 wt % of one or more kinds selected from the group consisting of dibasic acid, PCA and salts thereof, and (E) an inorganic salt, are superior in foaming performance, imparting conditioning property in a series of hair washing processes of washing, rinsing and drying, and hair appearance after drying.Type: ApplicationFiled: March 12, 2021Publication date: September 2, 2021Inventors: Richard J. BRUEN, JR., Naoaki IKEDA
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Publication number: 20210267870Abstract: There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACT1 peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, ?-lapachone, ?-hydroxy-beta-methyl-butyrate, Bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (?)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-?-glycyrrhetinic acid, 18-?-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (Na AD), nicotinic acid mononucleotide (Na MN), parsley (Petroselinium crispum), phenylephrine, pokeweedType: ApplicationFiled: July 10, 2019Publication date: September 2, 2021Applicant: NUCHIDO LIMITEDInventors: Nichola Jane Conlon, Malcolm Philip Young
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Publication number: 20210267871Abstract: The present disclosure relates to hair cosmetic compositions comprising: (a) at least one sugar alcohol: (b) at least one saccharide compound, and mixtures thereof; (c) pectin; (d) at least one water-soluble solvent; and (e) water. The hair cosmetic compositions provide excellent hair styling benefits without requiring synthetic film-forming polymers and/or silicones. In particular, the hair cosmetic compositions are useful for imparting to hair, durable styling or shaping benefits, curl definition, curl regularity, shape/styling control, shine, and frizz control.Type: ApplicationFiled: February 28, 2020Publication date: September 2, 2021Applicant: L'OREALInventor: Dhara PARIKH
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Publication number: 20210267872Abstract: The present invention provides novel methods for repairing or reducing skin changes as well as systems, regimens, and cosmetic compositions thereof. The invention relates to a cosmetic composition comprising electrospun polymer fibers, at least one active ingredient, and at least one cosmetically acceptable carrier is provided, wherein the electrospun fibers are dispersed in the composition. The composition is in form of a solution, suspension, lotion, cream, gel, emulsion, toner, ointment, paste, foam, hydrogel, film-forming product, or facial skin mask. The composition comprises at least one active ingredient and further comprises antioxidants, moisturizers, surfactants, or humectants.Type: ApplicationFiled: March 1, 2021Publication date: September 2, 2021Inventors: Snehal M. SHAH, Daniela BRATESCU, Isaac David COHEN, Zhihan ZHOU, Mary Ann SMAIL, Milan Franz SOJKA, Joe H. COLAS, Peter A. LANDA
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Publication number: 20210267873Abstract: The subject matter of the present disclosure are agents for oxidative hair lightening or hair coloring, containing 70-90% by weight of a total of % water, oxidation dye precursor(s), alkalizing agent(s), and a certain mixture of a crosslinked copolymer of acrylic acid and non-ethoxylated esters of acrylic acid with linear C10-C30 monoalcohols, anionic surfactant, cationic or zwitterionic polymer and linear, saturated C8-C22 alkan-1-ol, and sodium polyacrylate, giving the whitening or coloring agent an application-optimal viscosity and the consistency of a gel-like cream with an excellent feel.Type: ApplicationFiled: June 14, 2019Publication date: September 2, 2021Applicant: Henkel AG & Co. KGaAInventors: JUERGEN SCHOEPGENS, CHRISTA ROHLAND, GABRIELE WESER
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Publication number: 20210267874Abstract: The present invention provides a composition for preventing adhesion of air-borne fine particles, which contains a 2-(meth)acryloyloxyalkyl phosphorylcholine-(meth)acrylic acid alkyl ester copolymer as an antistatic agent, and which is not decreased in the effect of preventing adhesion of air-borne fine particles even if a sufficient amount of an oil component is blended therein. The present invention is characterized by containing (A) 2-(meth)acryloyloxyalkyl phosphorylcholine-(meth)acrylic acid alkyl ester copolymer, (B) a di-long-chain cationic surfactant represented by formula (I) (wherein each R1 independently represents and alkyl group having 12-22 carbon atoms and 0-3 double bonds; each R2 independently represents an alkyl group having 1-3 carbon atoms and no double bond; and Y represents a halogen atom, a methosulfate or a methophosphate), and (C) one or more oil components selected from among hydrocarbon oils, ester oils and silicone oils.Type: ApplicationFiled: June 21, 2019Publication date: September 2, 2021Applicant: Shiseido Company, Ltd.Inventors: Kazuyuki MIYAZAWA, Shoko ARINO, Hirohito SHIRAKAMI, Maki HORIMOTO
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Publication number: 20210267875Abstract: A tooth whitening composition includes a hydrophobic copolymer, a hydrophilic whitening agent and a polar solvent.Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Applicant: Colgate-Palmolive CompanyInventors: Rong Dong, Guofeng Xu
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Publication number: 20210267876Abstract: The present invention relates to a detergent containing or prepared by blending: (A) at least one selected from the group consisting of an alkyl sultaine, an alkyl hydroxysultaine, and a nonionic surfactant; and (B) an aminopolyether-modified silicone containing a polyoxyalkylene structure and satisfying the following formula (I): 0.01?Si/AO?1.6??(I) [in the formula (I), Si represents a molar number of a silicon atom in the component (B), and AO represents an oxyalkylene average addition molar number in the component (B)], wherein a mass ratio [(A)/(B)] of the component (A) to the component (B) is 0.1 or more and 1,000 or less.Type: ApplicationFiled: June 10, 2019Publication date: September 2, 2021Applicant: KAO CORPORATIONInventor: Naoyuki YAMAZAKI
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Publication number: 20210267877Abstract: This is a topical solution primarily for protecting against mosquito bites while guarding against the sun. The primary agent is Avon SKIN SO SOFT®{oil}. The Avon SKIN SO SOFT® {oil} is being infused with Neutrogena® Ultra Sheer® Dry Touch Sunscreen {sunscreen}100+, pure essential Lavender Oil and any bran consisting of 300 mg of Liquid Vitamin C. These ingredients when combined provide for a single solution, rather than multiple layering of several products, that will ward off mosquitos while protecting the skin from the effects of the sun. This is a simple single solution having multiple purposes 1) keep mosquitos from biting and 2) protecting against the sun. Applying this single solution will take care of both issues, mosquitos and sun.Type: ApplicationFiled: February 29, 2020Publication date: September 2, 2021Inventor: Joyce Evelyn Davidson
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Publication number: 20210267878Abstract: Solid cleansing compositions and methods for the same are disclosed herein. The solid cleansing compositions may include a soap, a plant oil, and a hydrolyzed protein. The plant oil and the hydrolyzed protein may be present in an effective amount to maintain or increase hydration of skin. The plant oil may be or include a flaxseed oil, and the hydrolyzed protein may be or include a hydrolyzed milk protein.Type: ApplicationFiled: September 24, 2018Publication date: September 2, 2021Applicant: Colgate-Palmolive CompanyInventors: Qiang Wu, Shujiang CHENG, Juliana NWOSISI, Laurence DU-THUMM
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Publication number: 20210267879Abstract: The invention provides anti-itch compositions applicable to a user's scalp. In particular, the anti-itch compositions are particularly suitable for naturally curly hair types and also for users who use non-native hair (weaves), braided hair substantially comprising non-native hair and wigs. One composition is a fast-acting anti-itch remedy and another is a scalp moisturizer that conditions and enhances the scalp.Type: ApplicationFiled: February 29, 2020Publication date: September 2, 2021Inventors: KEENAN BEASLEY, KENYATA MARTIN
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Publication number: 20210267880Abstract: Disclosed are the skin care applications of a composition containing the partially purified extracellular metabolite isolated from Bacillus coagulans MTCC 5856. More specifically, the invention discloses the ability of the partially purified extracellular metabolite isolated from Bacillus coagulans MTCC 5856 to confer protection to the skin fibroblasts against UV induced cell damage and apoptosis, oxidative stress and inflammation.Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Applicant: SAMI LABS LIMITEDInventors: Muhammed MAJEED, Kalyanam NAGABHUSHANAM, Sivakumar ARUMUGAM, Furqan ALI, Shaheen MAJEED, Lakshmi MUNDKUR
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Publication number: 20210267881Abstract: Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.Type: ApplicationFiled: January 5, 2021Publication date: September 2, 2021Inventors: Reinhard Vehring, Michael Steven Hartman, David Lechuga-Ballesteros, Adrian Edward Smith, Vidya B. Joshi, Sarvajna Kumar Dwivedi
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Publication number: 20210267882Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.Type: ApplicationFiled: June 20, 2019Publication date: September 2, 2021Inventors: Ryota HORI, Shinpei NISHIMURA
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Publication number: 20210267883Abstract: The present invention is directed to an injectable intramuscular depot composition suitable for forming an in situ solid implant in a body, comprising a drug which is risperidone and/or paliperidone or any pharmaceutically acceptable salt thereof in any combination, a biocompatible copolymer based on lactic and glycolic acid having a monomer ratio of lactic to glycolic acid of about 50:50 and a DMSO solvent, wherein the composition releases the drug with an immediate onset of action and continuously for at least 4 weeks and wherein the composition has a pharmacokinetic profile in vivo that makes it suitable to be administered each 4 weeks or even longer periods.Type: ApplicationFiled: March 28, 2019Publication date: September 2, 2021Applicant: Laboratorios Farmacéuticos Rovi, S.A.Inventors: Ibon GUTIERRO ADURIZ, Guillermo FRANCO RODRIGUEZ
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Publication number: 20210267884Abstract: The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nanodispersion that can be readily aerosolized for inhalation.Type: ApplicationFiled: May 3, 2021Publication date: September 2, 2021Inventors: Jason Thomas McConville, Thiago Cardoso Carvalho, Kristina Schonhoff
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Publication number: 20210267885Abstract: Disclosed herein is an aqueous composition comprising 0.001-0.1% (w/v) atropine or a salt thereof, a water-soluble polymer, and buffer (I), which is at a pH range of 6 or lower, wherein the buffer (I) is at least one selected from the group consisting of a phosphate buffer, an aminocarboxylate buffer, a carbonate buffer, an acetate buffer, a tartrate buffer, a borate buffer, and trometamol.Type: ApplicationFiled: May 24, 2017Publication date: September 2, 2021Inventors: Donald TAN, Roger BEUERMAN, Hiroyuki ASADA, Kyohei TAKAHASHI, Koji SAKANAKA, Takashi MORIMOTO, Toyomi FUJISAWA
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Publication number: 20210267886Abstract: A gel-in-oil emulsion comprising a gelled water-soluble polymer, an oil, and a surfactant, and a transdermal absorption preparation comprising the gel-in-oil emulsion.Type: ApplicationFiled: June 27, 2019Publication date: September 2, 2021Applicants: Nippon Shokubai Co., Ltd., Kyushu University, National University CorporationInventors: Hiroyuki Ijima, Nana Shirakigawa, Emiko Yamamoto
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Publication number: 20210267887Abstract: The present invention refers to a set for the production of a ready-to-use chemo-therapeutic composition for intraperitoneal administration as an aerosol, wherein the set comprises an aqueous concentrate containing at least cisplatin in a first predetermined concentration and doxorubicin in a second predetermined concentration with a predetermined ratio of the first and the second concentration and having a pH value in the range from 3.0 to 7.0. The set further comprises a physiological aqueous carrier solution, which is for optional dilution of the concentrate depending on target concentrations of cisplatin and doxorubicin in the chemo-therapeutic composition to be applied. Further, the invention refers to a method for providing of a ready-for-use chemotherapeutic composition for intraperitoneal administration as an aerosol by using of a set, to a chemotherapeutic composition for intraperitoneal administration as an aerosol, and a use of the chemotherapeutic composition.Type: ApplicationFiled: June 24, 2019Publication date: September 2, 2021Inventors: Alexander HETZEL, Janek KIBAT, Ranjita SAHOO, Mona KIBAT
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Publication number: 20210267888Abstract: This invention relates to a pharmaceutical aerosol product suitable for administration by oral or nasal inhalation and its use in the treatment of respiratory diseases, in particular in the treatment of children. The aerosol composition comprises ciclesonide, ethanol and either 1, 1, 1, 2-tetrafluoroethane, or 1, 1, 1, 2, 3, 3, 3-heptafluoropropane.Type: ApplicationFiled: May 13, 2021Publication date: September 2, 2021Inventors: Helgert Müller, Renate Engelstätter, Ulrich Bildmann, Andrea Bauer, Paul McGlynn
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Publication number: 20210267889Abstract: A cavitation seed for drug delivery, and a drug delivery method using the same are disclosed. The cavitation seed according to the present invention comprises: a shell which forms the outer surface thereof to maintain the outer shape thereof within a fluid; and a core which is located inside the shell to determine buoyancy of the cavitation seed within the fluid. The cavitation seed can improve an effect of delivering a drug into a body since cavitation is induced by ultrasound at a position close to the epidermis. In addition, the cavitation seed can be applied in the delivery of various drugs as well as skin cosmetics, such as skin tone lightening agents, depilatories, hair restorers and skin fillers, skin analgesics, local anesthetics, agents for genetic diseases such as psoriasis, and agents for treatment of skin disease such as skin cancer.Type: ApplicationFiled: April 8, 2021Publication date: September 2, 2021Inventors: Jong Woo Seo, Jong Bum Seo, Gill Soo Song
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Publication number: 20210267890Abstract: Methods and compositions for enhancing an immune response, such as a mucosal immune response, to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites.Type: ApplicationFiled: September 20, 2019Publication date: September 2, 2021Inventors: Ellen K. Wasan, Kishor M. Wasan, Volker Gerdts, Stacy Strom
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Publication number: 20210267891Abstract: The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.Type: ApplicationFiled: March 16, 2021Publication date: September 2, 2021Applicant: ARBUTUS BIOPHARMA CORPORATIONInventors: Ian MacLachlan, Lloyd B. Jeffs, Lorne R. Palmer, Cory Giesbrecht
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Publication number: 20210267892Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.Type: ApplicationFiled: May 11, 2021Publication date: September 2, 2021Applicant: Technion Research & Development Foundation LimitedInventors: Marcelle MACHLUF, Tomer BRONSHTEIN
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Publication number: 20210267893Abstract: Novel artificial exosomes and methods for producing novel artificial exosomes are provided. Methods of delivering cargo molecules to a cell using artificial exosomes are also provided.Type: ApplicationFiled: January 21, 2021Publication date: September 2, 2021Inventors: Reka Agnes Haraszti, Anastasia Khvorova, Neil Aronin
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Publication number: 20210267894Abstract: A method for producing uniform-size liposomes is provided. The liposomes are coated with a sorting agent to yield a plurality of density-modified liposomes of different sizes. These liposomes are then separated using a densitometric method. The sorting agent includes both a density-modifying moiety and a targeting moiety.Type: ApplicationFiled: January 29, 2021Publication date: September 2, 2021Applicant: Yale UniversityInventors: Chenxiang LIN, Yang YANG
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Publication number: 20210267895Abstract: The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.Type: ApplicationFiled: April 12, 2021Publication date: September 2, 2021Applicant: ARBUTUS BIOPHARMA CORPORATIONInventors: Edward Yaworski, Kieu Lam, Lloyd Jeffs, Lorne Palmer, Ian MacLachlan
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Publication number: 20210267896Abstract: Compositions and methods for making and using proliposomal and liposomal formulations of chemotherapeutic agents are disclosed. The proliposomal and liposomal formulations of chemotherapeutics, as well as medicaments and dosage forms that include such formulations, can be used with treatment regimens for bladder cancer and urothelial cancer. Hence, the formulations, medicaments, and dosage forms of the invention are suitable to treat bladder cancers by intravesical administration and to treat urothelial cancers. The formulations according to the invention include (a) a taxane (e.g., paclitaxel, docetaxel) or cisplatin, (b) a first phospholipid, dipalmitoyl phosphatidylcholine (DMPC), and (c) a second phospholipid, dimyrsityl phosphatidyl glycerol sodium (DMPG). The proliposomal formulations form liposomes upon contact with an aqueous vehicle.Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Applicants: WESTERN UNIVERSITY OF HEALTH SCIENCES, TESORX PHARMA, LLCInventors: Guru V. BETAGERI, Natarajan VENKATESAN, Michael G. OEFELEIN, Ramachandran THIRUCOTE, Nitin Kumar SWARNAKAR, Teresa HONG
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Publication number: 20210267897Abstract: Disclosed are targeted sub-50 nanometer nanoparticles suitable for delivering bioactive agents of interest, and related compositions, methods, and systems, which improve the manufacturing, stability, efficacy and other aspects of therapeutic nanoparticles.Type: ApplicationFiled: April 23, 2021Publication date: September 2, 2021Inventor: Gretchen M. Unger
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Publication number: 20210267898Abstract: The present invention relates to a pharmaceutical formulation comprising at least one active pharmaceutical ingredient (API) having low aqueous solubility or a pharmaceutically acceptable salt thereof in the form of particles of a size between 1 and 800 nm, wherein said particles are encapsulated within a large microparticle of a size between 1 and 100 ?m formed by a matrix comprising at least an excipient. Therefore, the API is entrapped or encapsulated in the microparticles of excipients. This pharmaceutical formulation contains the pharmaceutical active ingredient having improved solubility and subsequently supra-bioavailability.Type: ApplicationFiled: June 28, 2019Publication date: September 2, 2021Inventors: Jose Maria LAGARON CABELLO, Cristina PRIETO LOPEZ, Jose Manuel VALLE BAZ, David GALAN NEVADO, Julia HRAKOVSKY
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Publication number: 20210267899Abstract: Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions using solventless mixing methods. Excess coating material that is not bound to a coated API particle may be removed by a sieving process. Coating and dosing ratios can also be optimized to minimize the amount of excess unbound coating material. Specifically, a coating ratio and/or a dosing ratio can be used to minimize the residual amount of excess unbound coating material to minimize agglomeration of coating material during storage. In some embodiments, a pharmaceutical composition is provided, the pharmaceutical composition comprising: 65-85% w/w API particles; 15-30% w/w coating material coating the API particles; and 3-15% w/w matrix surrounding the coated API particles, wherein the pharmaceutical composition comprises a disintegration time rate of less than 10 seconds for at least six months under storage conditions of at least 25° C. and at least 60% relative humidity.Type: ApplicationFiled: May 4, 2021Publication date: September 2, 2021Applicant: Catalent U.K. Swindon Zydis LimitedInventors: Rosaleen MCLAUGHLIN, Simon Andrew Martyn HOWES, Craig WHEADON, Jonathon WHITEHOUSE
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Publication number: 20210267900Abstract: The present invention relates to a pre-processing method for the purpose of formulating a drug substance having non-uniform particle sizes by a manufacturing method having excellent manufacture performance. According to the pre-processing method of the present invention, additives including at least a dispersant are blended in a drug substance having a specific particle size distribution and then the resultant mixture is deagglomerated/sized to disperse and make adhere the additives onto the surfaces of the particles of the drug substance, thereby yielding a powder having a specified particle size distribution. In this manner, a pharmaceutical preparation can be manufactured with excellent manufacture performance, manufacture efficiency, and manufacture cost by a direct compression method, a wet continuous granulation system or the like. Therefore, the pre-processing method is very useful.Type: ApplicationFiled: June 25, 2019Publication date: September 2, 2021Applicant: NIPPON ZOKI PHARMACEUTICAL CO., LTD.Inventors: Hiroshi SAKAMOTO, Kunio KOMAI, Kiyoshi FUKUDA, Kensuke NAMBA, Kaori SHIMOAKA
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Publication number: 20210267901Abstract: This invention provides novel solid pharmaceutical compositions and processes for the bulk production of said compositions This invention also provides methods of using the pharmaceutical compositions in the treatment of cancer.Type: ApplicationFiled: January 11, 2021Publication date: September 2, 2021Inventor: Bhavishya Mittal
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Publication number: 20210267902Abstract: The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and/or a SGLT-2 inhibitor drug, and metformin XR, processes for the preparation thereof, and their use to treat certain diseases.Type: ApplicationFiled: December 16, 2020Publication date: September 2, 2021Inventors: Masanori ITO, Kenji EGUSA, Roman MESSERSCHMID, Peter SCHNEIDER
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Publication number: 20210267903Abstract: Disclosed herein are novel compositions and methods for controlling the release of bile acid sequestrant to the stomach in order to treat or prevent upper GI tract disorders or disorders of the throat. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant dispersed in a polymeric matrix. The bile acid sequestrant composition may be administered alone or in combination with at least one proton pump inhibitor, and optionally one or more agents chosen from antacids, histamine H2-receptor antagonists, y-aminobutyric acid-I3 (GABA-B) agonists, prodrugs of GABA-B agonists, acid pump antagonists, protease inhibitors and GC-C agonists.Type: ApplicationFiled: May 7, 2021Publication date: September 2, 2021Inventors: Vasu Sethuraman, David Bruce HEDDEN, Kristen Marie LESKOW
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Publication number: 20210267904Abstract: In an aspect, an extrusion printer is provided comprising a print head comprising one or more nozzles suited for 3D printing of a pharmaceutical product. A metering pump is coupled to the print head and is arranged to control a flow to said print head and an extruder device comprises an input arranged to receive a powder or pellet material. A three-way pressure valve is fitted between the metering pump and the extruder device to automatically distribute a constant output flow from the extruder to an input flow directed towards the metering pump and a remainder flow directed towards the overflow outlet.Type: ApplicationFiled: July 5, 2019Publication date: September 2, 2021Inventors: Leonardus Antonius Maria BROUWERS, Marcus Benedictus HOPPENBROUWERS, Antonius Paulus AULBERS, Godefridus Hendrikus Willebrordus VERHOEVEN
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Publication number: 20210267905Abstract: A tablet press for producing tablets including: a press chamber, a receiving chamber, a first material container having the first active substance with a first dosing device, a controller, and an input device. The press chamber has an extendable upper punch, an extendable lower punch, and a die. The input device inputs a target indicating a number of produced tablets and a target mass indicating a quantity of the first active substance and transmits the target number and the target mass to the controller. The controller actuates the first dosing device, the upper punch, and the lower punch such that a quantity of the first active substance that corresponds to the target mass is filled into a central opening of the die and pressed by the punches to form a tablet, and to repeat until the target number of tablets are produced.Type: ApplicationFiled: May 11, 2021Publication date: September 2, 2021Applicant: 4K GLOBAL HOLDING UG (HAFTUNGSBESCHRANKT)Inventor: Ingo KRAUSE
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Publication number: 20210267906Abstract: An oral solid dosage form comprising a mixture of compound of formula I and a fusible polymeric carrier; and optionally pharmaceutically acceptable excipients, wherein the mixture is an amorphous dispersion.Type: ApplicationFiled: May 13, 2021Publication date: September 2, 2021Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITEDInventors: Yashoraj ZALA, Bramhanand HANAMANNAVAR, Nitin DHARMADHIKARI
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Publication number: 20210267907Abstract: A water-soluble microencapsulated cannabinoid powder consisting essentially of a cannabinoid composition and at least one gum Acacia, and a method of making the same are provided.Type: ApplicationFiled: February 23, 2021Publication date: September 2, 2021Inventors: Stephanie Paredes, Alexander Amann
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Publication number: 20210267908Abstract: There is provided a dosages form comprising rivaroxaban and one or more pharmaceutically acceptable excipients. The present invention also provides a stable capsule dosage form comprising rivaroxaban and one or more pharmaceutically acceptable excipients. The invention also relates to process of preparation of such compositions.Type: ApplicationFiled: March 1, 2021Publication date: September 2, 2021Inventors: Rajnish Kumar SINGH, Tarun GARG, Muthulingam CHITHAMBARAM, Anil KUMAR