Abstract: A method of determining a ventilatory threshold for a subject engaged in an activity includes sensing heart rate information, breathing rate information, and motion information from the subject via a monitoring device worn by the subject; analyzing the heart rate information to identify one or more points in time where heart rate increased at a steady subject workload; and identifying the ventilatory threshold for the subject as occurring at a point in time where an increase in breathing rate lagged an increase in heart rate. The method also includes modifying when the ventilatory threshold for the subject occurs in time by presenting to the subject musical audio having a tempo correlated to frequency characteristics of a heart rate and/or breathing rate of the subject.

Abstract: An object is to provide a technique for removing fluctuations caused by a change in posture of a target from which a blood flow velocity is acquired when measuring the blood flow velocity. The present technology provides a biological information acquisition device including: a blood flow velocity measurement unit that is installed on a head; a detection unit that detects a position change amount of the blood flow velocity measurement unit, a moving velocity of the blood flow velocity measurement unit, or the position change amount and the moving velocity of the blood flow velocity measurement unit; a correction information generation unit that generates correction information of a blood flow velocity on the basis of the position change amount, the moving velocity, or the position change amount and the moving velocity; and a correction unit that corrects the blood flow velocity measured by the blood flow velocity measurement unit using the correction information.

Abstract: A pulse waveform measurement system includes an LED light source providing an incident beam having a predetermined wavelength onto a radial or other artery, samples reflected light at a predetermined sample rate, computes, and displays a pulse waveform and various parameters associated therewith. The wavelength and sample rate are set so as to provide desired data quality.

Abstract: A capacitive pressure sensor for a pressure-sensing guidewire or catheter includes a substrate; a first active cell formed in the substrate; a second active cell formed in the substrate, wherein the first active cell and the second active cell are electrically active to generate electrical signals representative of an external pressure; and an optional dummy cell formed in the substrate, wherein the dummy cell is electrically inactive such that no electrical signal representative of the external pressure is generated. An intraluminal pressure-sensing device and a system are also provided.

Abstract: A system and method is presented for cuff-less blood pressure measurement in a mobile device. A key aspect of this disclosure is the discovery of a new location for blood pressure measurement at the fingertip of a subject and that reflectance-mode photoplethysmography can be used to help make this measurement. Through experiments in human subjects, it was discovered that it is indeed possible to measure systemic blood pressure by having a subject press the fingertip against a reflectance-mode photo-plethysmography-force sensor unit under visual guidance and then compute blood pressure from the resulting variable-amplitude blood volume oscillations and applied pressure via an oscillometric algorithm.

Abstract: A sensor head assembly includes a body member having an internal passage. An optical source is secured to the body member at a first location, and an optical detector is secured to the body member at a second location. An audio driver is secured to the body member. An ear gel configured to be inserted within an ear canal is attached to the body member and has at least a portion thereof transparent to one or more wavelengths of light. A first light guide is secured to an inner surface of the ear gel via a respective first end, and a second light guide is secured to the inner surface of the ear gel via a respective first end. A second end of the first light guide is in optical communication with the optical source, a second end of the second light guide is in optical communication with the optical detector.

Abstract: Provided is an electronic device capable of precisely measuring an effect of continuously performed cosmetic treatment and the like based on biological information acquired from a video, a control method for the electronic device, and a storage medium.

Abstract: Examples of the disclosure relate to an apparatus, method and computer program for determining biometric parameters. The apparatus comprises means for: obtaining a signal from a broadband detector in response to light that has been propagated through a subject being incident on the broad band detector. The signal that is obtained comprises at least a first component and a second component. The first component is provided in response to a first spectral and spatial distribution of light being incident on the broadband detector and the second component is provided in response to at least one other spectral and spatial distribution of light being incident on the broadband detector.

Abstract: Provided is a biometric information measuring device 100, including a sensor module 20 that has N light-emitting elements 21 (N being an integer of 3 or more) that emit light having different wavelengths, and N?1 light-receiving elements 22 that receive light emitted from the light-emitting elements 21 and reflected by a biological tissue 10 and that output signals corresponding to the light having different wavelengths; and a signal processing unit that executes signal processing based on the output of the light-receiving elements 22, in which at least two light-emitting elements 21 are disposed on a circumference at a constant radius from light-receiving elements 22 of the sensor module 20 as a center.

Abstract: The present invention relates to apparatus for measuring physiological parameters in a blood vessel. The apparatus comprises at least one acoustic sensor positionable on a part of a subject's body which is configured to receive an acoustic signal from a target blood vessel. The acoustic sensor is attached to the part of the subject's body by an attachment means.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for neuroanatomical tract visualization using synaptic connectivity graphs. In one aspect, a method comprises: presenting, to a user and through a display, a representation of a synaptic connectivity graph representing synaptic connectivity between neurons in a brain of a biological organism; receiving, from the user, data specifying a seed neuron in the brain; identifying a neuroanatomical tract corresponding to the seed neuron in the brain; and presenting, to the user and through the display, a geometric representation of at least a portion of the brain of the biological organism that visually distinguishes the neuroanatomical tract corresponding to the seed neuron at neuronal resolution.

Abstract: A method for training a system for predicting a probability of occurrence of cardiac event is provided. The method includes obtaining sets of electrocardiograms of subjects, each set of electrocardiograms comprising at least one electrocardiogram each obtained, a) prior to and b) during or after an occurrence of a cardiac event, or both. The method includes extracting a first approximation of a time series data. The method also includes obtaining electrocardiograph signals that produced the electrocardiograms. The method also includes creating a training dataset from the extracted time series signals and the electrocardiograph signals for training a first and a second approximation of an electrocardiogram for representing an electrocardiograph signal that produced the electrocardiogram. The method further includes training a second model for extracting a cardiac marker from the second approximation of the electrocardiogram of the subject and calculating a probability of occurrence of a cardiac event.

Abstract: A method of processing ECG data includes generating a first feature set with a trained neural network using ECG data and processing a patient's ECG data using a criteria-based algorithm to generate a second feature set. The patient's ECG data is then clustered into a number of clusters based on the first feature set and the second feature set to generate clustered ECG data. The clustered ECG data is presented to a user via a user interface, and user input is received from the user via the user interface regarding the clustered ECG data. A feature vector is defined based on the user input and the feature vector is applied to at least a portion of the patient's ECG data to generate revised clustered ECG data. The revised clustered ECG data is then presented to the user via the user interface.

Abstract: Disclosed are an EEG signal generation network, method and storage medium. The EEG signal generation network includes a real EEG signal input end, a real EEG signal labeling module, a generator, a sharing module, a discriminator, and a classifier. The EEG signal generation network is configured to minimize losses of the generator, discriminator and classifier, and to minimize a combined loss of the discriminator and classifier through training, and to generate a new event-related potential.

Abstract: Embodiments of the present invention provide a magnetic resonance scanning method and system and a computer-readable storage medium. The method comprises: when an imaging volume of an object is at a current position, performing a current imaging scan on the imaging volume based on a predicted overall BO field map at the current position.

Abstract: In one embodiment, a biological information monitoring apparatus includes: an antenna assembly including at least one antenna, the antenna assembly being disposed close to an object; a signal generator configured to generate a high-frequency signal; and a displacement detection circuit configured to detect a physical displacement of the object based on the high-frequency signal, wherein the at least one antenna includes: a main antenna to be supplied with the high frequency signal; and a parasitic element to which the high frequency signal is not supplied.

Abstract: A radiofrequency receive coil assembly can include a first conductive loop and a second conductive loop electrically connected at a node. The first and second conductive loops can extend into a treatment beam region of the radio frequency receive coil assembly through which one or more beams of ionizing radiation pass. The first conductive loop and the second conductive loop can overlap each other to provide electromagnetic isolation and/or can use a common conductor combined with a shared capacitor to provide electromagnetic isolation, with the shared capacitor or other electrical components, as well as any conductive loop overlaps, being positioned outside of the treatment beam region. These features can, among other possible advantages, minimize and homogenize attenuation of the beams of ionizing radiation by the radiofrequency receive coil assembly.

Abstract: A system for determining conditions within or near an implant apparatus in region of a subject includes an implant apparatus configured to be piezoresistive, the implant apparatus positioned in a region of a subject having a surface, and an electrical impedance tomography system. The electrical impedance tomography system includes a plurality of electrodes disposed on the surface of the region of the subject, each of the plurality of electrodes configured to apply a current to the region of the subject and to receive measurement signals from the region of the subject in response to an applied current.

Abstract: A physiologic sensor for measuring the partial pressure of carbon dioxide is provided. The sensor includes a generally C-shaped in cross-section sensor cover, the sensor cover defining an opening on an underside thereof; a membrane body housed within the opening, the membrane comprising an amorphous fluoroplastic, the membrane including a first end and a second end and defines a chamber therewithin; a sensor body for coupling the membrane to the sensor cover; two or more electrodes positioned within the membrane chamber; and a substantially electrolyte-free liquid contained within the membrane chamber and in contact with the two or more electrodes.

Abstract: Embodiments disclosed herein are directed to devices that include 17-7 precipitation hardened stainless steel and can be magnetized to provide a magnetic field. The magnetic field can be detected by a tracking system that determines a location of the device, for example within a patient. The device formed of 17-7 precipitation hardened stainless steel can display superiority in magnetic tracking properties, including an improved immunity to magnetic interference and improved pairing and drop-out distance. This is of particular importance where tracking systems are highly sensitive to interference magnetic sources, such as smart phones or the like, and which would otherwise need careful calibration or complex algorithms to account for such interferences.

Abstract: An implantable device including a housing, circuitry within the housing, and a power source attached to the housing and electrically connected to the circuitry. The device may include electrically conductive connectors configured to electrically connect positive and negative terminals of the power source to the circuitry. The device may include a power source terminal enclosure attached to the power source and configured to enclose the positive and negative terminals of the power source. The power source terminal enclosure may include holes through which the electrically conductive connectors pass. The device may include a housing cap enclosure attached to the power source terminal enclosure and to an open end of the housing. The housing cap enclosure may enclose the circuitry within the housing and includes passages through which the electrically conductive connectors pass.

Abstract: Systems and methods are provided for monitoring the sedation level of patients. Images may be captured of a patient and regions of interest identified. Changes to image properties or to one or more regions of interest may be analyzed to generate physiological parameters for the patient. Physiological parameters may include information related to the patient's breathing behavior and/or activity. Physiological parameters may be used to determine a sedation level of the patient. If it is determined that the patient is over- or under-sedated, appropriate action may be taken, such as displaying an indication, activating an alarm, and/or causing an amount of sedative to be administered to the patient.

Abstract: A mouthpiece for a device for measuring analytes in exhaled air includes a gas path configured to convey exhaled air to the device and a film arranged so as to block the conveying of the exhaled air through the gas path. A system, in one embodiment, includes the mouthpiece and a device configured to measure analytes in the exhaled air. The mouthpiece is configured to be releasably connected to the device. The device includes a pressure sensor and, in one embodiment, a pump configured to pump air via the mouthpiece when connected to the device. The device is configured to be enabled to measure predefined analytes in the exhaled air when a pressure curve measured via the pressure sensor satisfies one or more predefined conditions.

Abstract: In accordance with embodiments, methods and systems for utilizing multiple threshold checkers are provided. A range sensor collects measurement data. The range sensor examines the measurement data based on multiple threshold checkers to determine satisfaction of a trigger condition. In response to the satisfaction of the trigger condition, the range sensor provides the measurement data to a host computing device of the range sensor.

Abstract: Analysis of a breath sample is a noninvasive point-of-care tool with ever increasing clinical applicability. Herein we describe a method to analyze the content of low-level, trace volatile organic compounds from alveolar breath captured as a breath sample from a patient suspected of having a fatty liver disease. The breath sample is then analyzed using a gas phase analysis methodology, such as gas chromatography-mass spectroscopy (“GCMS”), to generate an analysis result, such as a GCMS spectrum. A computer system is then used to develop a fingerprint pattern from the analysis result. The fingerprint pattern is then used to determine a patient status for the patient. The fingerprint pattern is typically a grouping of 75 to 450 compounds of known concentration which are indicative of a particular fatty liver disease.

Abstract: The present invention is a breath sample collecting mask comprising a mask body and a breath sample collector that provides non-invasive sample collection for detection of infectious diseases as well as lung and respiratory diseases, potentially before the onset of symptoms. The breath sample collector contains a filter that catches viral, bacterial, and other biomarker particles. The breath sample collector can be removed from the mask and placed into a tube for sample elution and further processing and analysis. The breath sample collecting mask may further comprise a thermometer, electrodes attached on the filter of the sample collector, and a microprocessor to monitor the mask wearer's condition.

Abstract: Described herein is a method and apparatus for storing a sample of human breath, which includes a metering device having an inlet port and a delivery port; a dispenser device in fluid communication with the delivery port of the metering device; a supply unit configured for delivering a flow of fluid through a delivery port of its own; an acquisition port configured for intake of a sample of human breath; and a selection valve. The selection valve includes a first operating condition, in which a fluid communication is obtained between the acquisition port and the inlet port of the metering device, and a second operating condition, in which a fluid communication is obtained between the delivery port of the supply unit and said metering device.

Abstract: Existing wearable device-based approaches to capture tremor signal have accuracy limitations due to usage of accelerometer sensor with inherent noisy nature. The method and system disclosed herein taps characteristics of the PPG sensor of being sensitive to the motion artefact, as an advantage, to capture tremor signal present in the PPG sensor. The method disclosed herein describes an approach to extract tremor signal of interest from the PPG signal by performing a Singular Spectrum Analysis (SSA) followed by spectrum density estimation. The SSA comprises performing embedding on the acquired PPG signal, performing Principal Component Analysis (PCA) on the embedded signal and reconstructing the rest tremor signal from the significant principal components identified post the PCA. Further, the spectrum density estimation detects a dominant frequency present in the principal components, which is the dominant frequency associated with the rest tremor.

Abstract: A system for measuring and assessing biometrically determined changes in gait is provided. The system includes a processor, a memory, and instructions written on the memory, wherein the instructions when executed by the processor cause the system to: acquire a baseline gait pattern, acquire a subsequent gait pattern; compare the baseline gait pattern to a subsequent gait pattern, interpolate the baseline gait pattern and the subsequent gait pattern, validate the baseline gait pattern and the subsequent gait pattern, correlate the baseline gait pattern and the subsequent gait pattern; update the baseline gait pattern, predict a likelihood of a flare-up, and communicate the likelihood of a flare-up to a user.

Abstract: One or more radar sensors can be used to monitor patients in a variety of different environments and embodiments. In one embodiment, radar sensors can be used to monitor a patient's movement, including movement in a patient bed and around a room. In another embodiment, a patient position can be monitored in a patient bed, which can be used as feedback for control of bladders of a patient bed. Additional embodiments are described herein.

Abstract: Disclosures of the present invention describe a system for recognizing abnormal activity of human body using wearable electronic device and mixed reality technology, comprising: a first wearable electronic device, a plurality of second wearable electronic devices, at least one camera, and a judgement module. This novel system is suitable for applying in any kinds of work environment, so as to monitor and determine whether a user (i.e., an operator or an employee) exhibits abnormal activities by referring a document of standard operating procedures (SOP), an operating manual and a document of safety operation standard (SOS), such that it is facilitated to reduce a happening rate of the user's mishandling, thereby achieving the enhancement of work efficiency and productivity.

Abstract: A rehabilitation device is for monitoring hand movement of a user in which one or both forearms are supported on a forearm support region of a support, and an upward facing camera is mounted with a field of view forwards beyond the front of the forearm support to capture an image of the hand or hands, which extend in front of the forearm support region. This avoids the need for the user to wear a sensor glove but also enables a compact system without needing an overhead camera or a large table arrangement.

Abstract: An illuminable orthostatic reporting apparatus may include a laser pointer disposed within an adjustable housing mount assembly that may be coupled to a harness assembly; the reporting apparatus may be used with a target; the target may be an electronic target configured to report whether a user wearing the reporting apparatus is maintaining a laser beam, emitted from the laser pointer, in an aligned position with the target.

Abstract: Aspects include identifying each of a plurality of audio sources proximate to a user wearing a headset. The audio sources include a primary audio source and a plurality of background audio sources. Aspects include causing the headset to play a set of audio sources to the user by causing each audio source of the set to be unfiltered by the headset. Aspects include determining an acceptance level of the user. Aspects also include determining a background noise filtering adjustment based on the acceptance level and the set of audio sources being played by the headset to the user. Aspects also include causing the headset to adjust a filtering of one or more of the plurality of background audio sources by the headset based on the background noise filtering adjustment.

Abstract: A method of measuring a physiological characteristic of a user obtains first calibrating sensor data indicative of an analyte level of the user, and produced in response to operation of a continuous analyte sensor device during a calibration period, and obtains second calibrating sensor data indicative of status or condition of the user, and produced in response to operation of a noninvasive sensor device, concurrently with operation of the continuous analyte sensor device, during the calibration period. A correlation measurement is calculated by comparing the first calibrating sensor data against the second calibrating sensor data. When the correlation measurement exceeds a threshold value, a transfer function is generated to calculate estimated values of the analyte level as a function of sensor data from the noninvasive sensor device. The transfer function is provided to a client device associated with the user.

Abstract: It is provided a device for non-invasively and continuously extracting interstitial fluid comprising or not comprising an immunogenic compound from the skin of a subject comprising an electroporator generating a non-pulsed voltage coupled to a pulsed voltage between at least one moving electrode and an electrical conducting adhesive for non-heating irreversibly electroporating the skin; a vacuum pump providing a negative pressure above the skin; and a collecting chamber for collecting the interstitial fluid extracted from the skin wherein the device can be used for detecting Covid-19 and/or extracting an antibody produced in the subject.

Abstract: An application running on a device to manage insulin site rotation may read a configuration file including a group, a plurality of sites in the group, and an image associated with the group. The application may detect an input selecting a site from the plurality of sites for administration of an insulin management device. The application may also set the selected site as unavailable for a predetermined duration in response to the input selecting the site. A log entry may be written to track usage of the site in response to the input selecting the site. A visual indicator on the selected site may show that the site is recently selected in response to detecting the input selecting the site within a predetermined duration. The insulin management device may be a pump, a syringe, or a glucose monitor.

Abstract: A portable analyte detection, monitoring and modeling system and related methods are provided. The detection system includes a detector having one or more probes and associated detector circuitry that is in communication with a mobile device. The system is in communication with a server, where the detection system transmits analyte detection signals. The analyte detection signals are transmitted in real-time and the detection system receives analyte level information determined by the server. The server may process data from multiple probes to track multiple analytes or a single analyte based on the multiple different probe data from a single detector. Predictive modeling is implemented to signal remedial or preventative measures.

Abstract: A system and method to measure blood oxygenation levels and total hemoglobin on individually selected blood vessels, to provide a representation of the subject condition and of tissue perfusion that may be used for diagnosing specific tissue conditions. Reflection spectra from individual blood vessels or a collection of vessels are measured by using wide-field imaging for selecting target vessels and a narrow-field confocal detection system to enable measuring local blood oxygenation and hemoglobin. Optical fibers may be used to illuminate the target vessel and to detect light diffusively reflected therefrom. The reflection spectra may be analyzed in a spectrometer to extract the ratio of the deoxy- to oxyhemoglobin and to determine their absolute concentration for computing total hemoglobin levels. An alternative implementation uses image processing on camera images of a blood vessel, generated at an isosbestic wavelength of the deoxy- and oxyhemoglobin, and optionally also at neighboring wavelengths.

Abstract: An automated urine-output-measurement system can include single-patient equipment and multi-patient equipment. The single-patient equipment can include a urinary catheter and a urine-collection system. The urine-collection system can include drainage tubing and a drainage receptacle. The multi-patient equipment can include a urine monitor. The urine monitor can include a housing having a cavity configured to house the drainage receptacle, a urine-measurement means for measuring urine-output into the drainage receptacle, and an integrated display screen configured to display patient information including measurements of the urine output. A method of the automated urine-output-measurement system can include placing the drainage receptacle in the urine monitor of the automated urine-output-measurement system, and confirming a volume of urine in the drainage receptacle with that indicated on the urine monitor once a patient has produced urine.

Abstract: Systems and methods rely on feedback from an active medical device or devices (e.g., neurostimulator coupled to sensing and stimulation elements such as electrodes) to assess the effectiveness of a patient's drug regimen. Such reliance may include analyzing characteristics in physiological data acquired by the medical device(s), for example, in the form of responses evoked from the patient by electrical stimulation waveforms. Systems and methods further involved adjusting one or more parameters according to which a combination therapy consisting of at least a drug regimen and an electrical stimulation therapy are delivered to a patient, in an effort to optimize the therapeutic effect of the combination. The adjustments may be automatically by one or more implanted or external hosts working together or alone, and/or with the input of a physician.

Abstract: Provided are an electrode sensor and a method for fabricating the same. According to embodiments, an electrode sensor includes: an organic substrate including a polymer; an organic insulating pattern which is disposed on the organic substrate and has an opening through which the organic substrate is exposed; a conductive layer which is disposed on the organic substrate and within the opening of the organic insulating pattern; and a passivation pattern which is disposed on the organic insulating pattern and through which a portion of the conductive layer is exposed. The conductive layer may include a conductive polymer, and the conductive layer may be coupled to the organic substrate by a covalent bond.

Abstract: A catheter comprising an elongated catheter body, an electrode array distal of the catheter body, the array having a mounting member and at least first and second spine supports. Each spine support includes a base having a planar configuration, and a plurality of spines extending from the base, wherein the first base extends in a first plane and the second base extends in a second plane different from the first plane in the mounting member.

Abstract: At least one of first and second wireless sound converting devices of a wireless sound converting system includes: an internal electrode unit mounted on a first side of a body portion and configured to detect electrocardiogram (ECG), and an external electrode unit mounted on the opposite side or side adjacent the opposite side and including an ECG sensor configured to apply a first detection value related to ECG to a data processor and a photoplethysmography (PPG) sensor mounted on the first side of the body portion and configured to detect PPG and apply a second detection value related to PPG to the data processor. With the wireless sound converting device that includes the ECG sensor mounted on a wearer's ear, the corresponding data processor is configured to emit sound of a message for configuring a bio-signal transmission path using the wearer's body through the speaker to measure ECG.

Abstract: Systems and methods are described herein for detecting efficiency of pacing using external cardiac signals. A representative electrical signal morphology of the cardiac signals may be determined based on the plurality of electrical signals, and an efficacy of left bundle branch (LBB) engagement determined based on the representative electrical signal morphology.

Abstract: A novel method for using the widely-used electroencephalography (EEG) systems to detect and localize silences in the brain is disclosed. The method detects the absence of electrophysiological signals, or neural silences, using noninvasive scalp electroencephalography (EEG) signals. This method can also be used for reduced activity localization, activity level mapping throughout the brain, as well as mapping activity levels in different frequency bands. By accounting for the contributions of different sources to the power of the recorded signals, and using a hemispheric baseline approach and a convex spectral clustering framework, the method permits rapid detection and localization of regions of silence in the brain using a relatively small amount of EEG data.

Abstract: A surgical access system including a tissue distraction assembly and a tissue refraction assembly, both of which may be equipped with one or more electrodes for use in detecting the existence of (and optionally the distance and/or direction to) neural structures before, during, and after the establishment of an operative corridor to a surgical target site.

Abstract: An apparatus, module, methods and systems for automated, standardized assessment and analysis of a human olfactory system's odor detection ability as an indicator or predictor of cognitive impairment or change in cognitive health, and other health conditions such as diabetes. Notably, the present invention is operable for use across all age groups of humans and provides quantitative detection and analysis of a human olfactory system's detection ability compared to a relevant demographic population.

Abstract: A method of diagnosing a likelihood of onset or progression of Alzheimer's disease and related dementias (ADRD) in a subject is provided. The method requires determining vascularization changes in different regions of the brain on the basis of a quantitative cerebral blood volume (qCBV) map of the subject's brain. The qCBV is obtained from one or more quantitative ultrashort time-to-echo contrast-enhanced (QUTE-CE) MRI images of the brain. A method of treating a subject for ADRD is provided. Diagnostic markers for onset and progression of Alzheimer's disease are also provided.

Abstract: A method of detecting a seizure status of a subject includes collecting first data from a first accelerometer positioned on a first limb of the subject and a second data from a second accelerometer positioned on a torso of the subject, determining that one of the first accelerometer or the second accelerometer provides a better indication (e.g., greater level of sensitivity or a lesser level of a false positive rate) by comparing the first data and the second data, detecting an indication of the seizure status of the subject using at least one of the first data and the second data, and generating an alert in response to the detection of the indication of the seizure status of the subject.